1. Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome
- Author
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Funda Coskun, R. Oktay Gözü, Yesim Ozarda Ilcol, Ilker Ercan, Mehmet Karadag, Ahmet Ursavaş, Basak Burgazlioglu, Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı., Ursavaş, Ahmet, Karadağ, Mehmet, İlçöz, Yasemin, Ercan, İlker, Burgazoğlu, Başak, Coşkun, Funda, Gözü, R. Oktay, AAI-3169-2021, AAG-8744-2021, AAD-1271-2019, and AAL-8873-2021
- Subjects
Male ,Apnea ,Polysomnography ,Gastroenterology ,Obstructive Sleep Apnea ,Positive End Expiratory Pressure ,Sleep apnea, obstructive ,Insulin ,Insulin-like growth factor ,Middle aged ,Down-regulation ,Somatomedin-c ,Priority journal ,medicine.diagnostic_test ,Sleep apnea ,Insulin-like growth factor I ,Cardiovascular diseases ,Body mass ,Correlational study ,Insulin blood level ,Female ,Arousal ,Regression analysis ,Human ,Adult ,Pulmonary and Respiratory Medicine ,Hormone secretion ,medicine.medical_specialty ,Growth-factor-i ,Oxygen saturation ,Serum-levels ,Case-control studies ,Major clinical study ,Respiratory system ,Article ,Association ,stomatognathic system ,Internal medicine ,medicine ,Humans ,Obesity ,Risk factor ,Coronary-artery disease ,business.industry ,Body-mass ,Case-control study ,Gender ,Stepwise regression ,Somatomedin C ,medicine.disease ,Heart-disease ,nervous system diseases ,respiratory tract diseases ,Oxygen ,Obstructive sleep apnea ,Sleep apnea syndrome ,Severity of illness index ,Endocrinology ,Risk factors ,Fatty acid desaturation ,business ,Controlled study ,Body mass index - Abstract
The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.
- Published
- 2007
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