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Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South-Central Minzu University (Natural Science Edition) is the property of Journal of South-Central Minzu University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Diagnosis & Therapy on Dermato-venereology is the property of Dermatology Hospital of Southern Medical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Hydrobiology is the property of Editorial Department of Journal of Hydrobiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Harmonious coexistence between man and nature is the essential requirement of Chinese modernization. The study on the path of harmonious coexistence between man and nature is of great significance to the construction of a beautiful China. Explain the theoretical basis of the harmonious symbiosis between man and nature, clarify the deep connotation of the harmonious symbiosis between man and nature, on this basis, the paper discusses the path of harmonious coexistence between man and nature from three aspects of the implementation of the concept of green development, solving the dilemma of the harmonious symbiosis between man and nature; promoting the rule of law in environmental protection and building a harmonious coexistence between man and nature; sticking to the boundary of natural ecology, drawing a new picture of harmonious coexistence between man and nature, aiming at providing theoretical support for the construction of a beautiful China. [ABSTRACT FROM AUTHOR]

Copyright of Light Industry Machinery is the property of Light Industry Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Trimetazidine is a widely available coronary artery dilating drug. However, it is listed as prohibited by the World Anti-Doping Code. Herein, the polyimide tape is used as the substrate, and integrated graphene array electrodes are easily prepared by combining patterning design and laser engraving techniques. The effect of laser power on the structure and performance of graphene array electrodes is investigated. When the laser power is increased from 50% to 70%, the electrochemically active area, the electron exchange capacity, and the signal enhancement effect of the graphene arrays to trimetazidine gradually increase. However, these properties decrease as the power continues to increase to 80%. The electrochemical oxidation mechanism of trimetazidine is investigated, which involves the transfer of two electrons and two protons. Based on the laserinduced signal enhancement of graphene arrays, a sensitive and simple electrochemical method for the determination of trimetazidine is developed with the linear range of 0. 5~20 μmol/L and the detection limit of 0. 15 μmol/L. This method is successfully applied to the analysis of urine samples from healthy volunteers, and the recoveries of the spiked samples are in the range of 96. 0% to 106. 2%. [ABSTRACT FROM AUTHOR]

Copyright of Storage & Process is the property of Tianjin Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Condiment is the property of China Condiment and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Southeast University / Dongnan Daxue Xuebao is the property of Journal of Southeast University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Network & Information Security is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper examines the application of the erosion- deposition law to the multilevel bifurcating system of Yangtze River Estuary under dam-induced runoff flattening. The spatiotemporal pattern of erosion- deposition change and associated hydrodynamic mechanism are identified by analyzing water- sediment, terrain and engineering data from 1950 to 2021 in terms of a runoff intensity index Da(i. e., multiyear average days of runoff discharge ≥60 000 m 3 / s), tracked positions of stagnation points, and estimates of restored erosion- deposition volume of the north passage according to navigation dredging data. It is found that the ebb partition ratios of the north and south branching channels tend to increase and decrease, respectively, as Da grows; this aggravates erosion and impedes deposition in the north branching channels while facilitating deposition and restraining erosion in the south branching channels. Meanwhile, depo- centers in north and south branching channels move downstream and upstream. The foregoing changes in erosion- deposition are driven by hydrodynamic inertia and the flow- deflecting effect of nodes along the south bank. More specifically, the ebb flow axis swings either northward or southward as the runoff discharge varies, forming a linkage mechanism for the lateral- longitudinal erosion- deposition pattern between the north and south branching channels. As the runoff process becomes continuously flattened owing to upstream dam regulation activities, the north branching channels and their upper sub- reaches are likely to maintain a trend of deposition aggravation and erosion impediment, whereas their lower sub- reaches maintain a trend of erosion aggravation and deposition impediment. Conversely, the south branching channels are likely to witness an opposite trend in erosiondeposition. The critical runoff discharge for migration of the stagnation point between upper and lower sub-reaches in the north passage is 35 000 m 3 / s. At such a situation, additional deposition is expected to occur in the upper subreach, and timely maintenance adjustments would be required along key segments of the navigational channel. [ABSTRACT FROM AUTHOR]

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to accurately evaluate regional water resources carrying capacity and to identify the main factors affecting water resources carrying capacity, based on the ternary effect under the premise of full partial connection number, this paper derived the quaternion effect calculation formula of partial connection number by analogy, explained the internal mechanism, with the quaternion subtraction set pair potential, quaternion semi-partial subtraction set pair potential, compared the set pair potential, and applied to the evaluation of Huaibei Plain water resources carrying capacity. The results show that from 2011 to 2019, the water resources carrying capacity of the Huaibei Plain basically ranges from level 2 (critical load) to level 3 (critical overload), indicating that the water resources carrying capacity of the Huaibei Plain is generally poor. The results of the quaternion effect full partial connection number are consistent with the quaternion subtraction set pair potential and the quaternion semi-partial subtraction set pair potential; however, compared with the other two methods, the quaternion effect full partial connection number is more rational and more convincing. The quaternion effect full partial connection number can judge the development trend of set pair system well, and gives a new judgment method to solve the determinism and uncertainty of set pair system. [ABSTRACT FROM AUTHOR]

BACKGROUND: Deep vein thrombosis is one of the common complications after total knee arthroplasty. In recent years, enhanced recovery after surgery has developed rapidly. However, there is still a lack of large sample studies on the occurrence and risk factors of thrombosis after total knee arthroplasty in China. OBJECTIVE: To explore the occurrence of deep vein thrombosis in the lower extremities after total knee arthroplasty during enhanced recovery after surgery, and to further explore the risk factors for postoperative deep vein thrombosis. METHODS: A total of 1 260 patients who underwent unilateral total knee arthroplasty for knee osteoarthritis in the First Affiliated Hospital of Soochow University from May 2016 to December 2021 were retrospectively analyzed. According to the results of postoperative venous ultrasound of the lower limbs, the patients were assigned into thrombosis group (n=140) and non-thrombosis group (n=1 120). The differences of various indicators between the two groups were compared by univariate analysis. Finally, the possible meaningful indicators were taken as independent variables into the binary multivariate logistic regression analysis. RESULTS AND CONCLUSION: (1) 140 patients suffered from postoperative deep vein thrombosis, of which the incidence of proximal thrombosis was 1.67%, and the incidence of distal thrombosis was 9.44%. In the proximal type, 38.10% of the thrombus involved only one vein, and 61.90% of the patients involved two or more veins. Of the distal type, 79.83% involved a single vein and 20.17% involved two or more veins. (2) Univariate analysis results showed that the proportion of patients with a history of hypertension, a history of deep vein thrombosis and a history of drinking alcohol in the thrombotic group were significantly higher than those of the non-thrombosis group (P < 0.05). (3) Binary multivariate logistic regression analysis showed that a history of preoperative hypertension (OR=1.686, P=0.012, 95%CI=1.123-2.531), a history of deep vein thrombosis (OR=4.794, P < 0.001, 95%CI=2.124-10.820), and a history of alcohol consumption (OR=10.733, P < 0.001, 95%CI=6.942-16.594) were risk factors for the development of deep vein thrombosis after total knee arthroplasty. (4) The results show that although the incidence of proximal thrombosis is not high during the enhanced recovery after surgery, given that it often involves two or more veins, attention should be paid to the evaluation of thrombosis treatment in such patients. Preoperative history of hypertension, previous history of varicose veins, and the presence of alcohol consumption are independent risk factors for the development of deep vein thrombosis in the lower limbs after total knee arthroplasty, so surgeons should focus on the patient's general condition and perform preoperative optimization. [ABSTRACT FROM AUTHOR]

Copyright of Nonferrous Metals Engineering is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Mechanics / Gongcheng Lixue is the property of Engineering Mechanics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of World Regional Studies is the property of World Regional Studies Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of FoxM1 regulated by lentiviral transfection on the proliferation and invasion of human intrahepatic cholangiocarcinoma (ICC) and the expression levels of MMP-9 and MMP-2 in vitro. Methods Western blot assay was used to detect the FoxM1 protein expression levels of ICC cell lines HCCC-9810, RBE and SSP-25. The higher expression level of cell line was selected as the down-regulated FoxM1 cell line, and the lower one was selected as the up-regulated FoxM1 cell line. FoxM1 plasmid and shRNA lentiviral vector transfection targeting up)regulating and down-regulating ICC cell lines were established a cell line that stably up-regulating or down-regulating FoxM1 cells (verified by Western blot assay). MTT method was used to detect cell proliferation after transfection, and Transwell invasion test was used to detect cell invasion. qPCR was used to detect the expression levels of MMP-9 and MMP)2 mRNA in stably transfected cell lines of each group. Results The protein of FoxM1 expression of SSP-25 was the highest, and HCCC-9810 was the lowest. Therefore, SSP-25 was selected as the target cell line for down-regulating FoxM1 expression, and HCCC-9810 was selected as the target cell line for up-regulating FoxM1 expression. The lentiviral transfection successfully constructed stable overexpression (the HCCC-9810-FoxM1 group) and down-regulated FoxM1 cell line (the SSP-25-shFoxM1 group). The proliferation and invasion ability were significantly higher in the HCCC-9810-FoxM1 group than those of the HCCC-9810-Control group (P＜0.05). The proliferation and invasion ability were significantly lower in the SSP-25-shFoxM1 group than those of the SSP-25-Control group (P＜0.05). In the HCCC-9810- FoxM1 group, the mRNA expression levels of MMP-9 and MMP-2 were significantly higher than those of the HCCC-9810- Control group, while the mRNA expression levels of MMP-9 and MMP-2 were significantly lower in the SSP-25-shFoxM1 group than those of the SSP-25-Control group (P＜0.05). Conclusion FoxM1 promotes the proliferation and invasion of ICC cells. FoxM1 may affect the expression levels of MMP-9 and MMP-2. FoxM1 may serve as a potential biomarker of ICC. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Light Industry Machinery is the property of Light Industry Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Southeast University / Dongnan Daxue Xuebao is the property of Journal of Southeast University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the change of social environment and the influence of multiple values, the concept of love of postgraduates in universities in the new era has changed greatly compared with that of postgraduates in the middle and late 20th century. Post-graduates’ concepts of marriage and love have an important impact on the implementation effect of China's new population policy (three child policy). Through the questionnaire survey on postgraduates in Hubei province, the concept of love of male and female postgraduates in colleges is comprehensively displayed from the five aspects of love status, love attitude, love motivation, mate selection standard and marriage concept. It is found that there are great differences in the love views of male and female postgraduates. This paper mainly analyzes the reasons for the differences of love views between male and female postgraduates in universities from the four aspects: the empowerment of women by social development, the pressure of love consumption, the differences between male and female gender culture and the influence of family and marriage ideas. It suggests to optimize the cultivation environment of social love concept, strengthen the education of love concept in universities, and enhance the self-education of postgraduates, so as to guide postgraduates to form a correct love concept, actively pursue love, improve their ability to love, and achieve a happy marriage. [ABSTRACT FROM AUTHOR]

Copyright of Hydrographic Surveying & Charting / Haiyang Cehui is the property of Hydrographic Surveying & Charting Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the clinical value of dynamic contrast enhanced ultrasound (DCEUS) in monitoring therapeutic effect of high-intensity focused ultrasound (HIFU) in patients with solid abdominal malignant tumors by compare the quantitative ananlysis curve and perfusion parametters. Methods From Sep 2018 to May 2021, patients with histopathologically confirmed advanced abdominal malignant tumors and planned to receive HIFU treatment were prospectively included. Contrast enhanced ultrasound (CEUS) examinations were performed 1 day before and 4 weeks after the initiation of HIFU treatment.CEUS cines in DICOM form were converted into time intensity curves (TICs) using Vuebox software. Various quantitative CEUS parameters were generated after curve fitting, including peak enhancement (PE), rise time (RT), time to peak (TTP), mean transit time (mTT) and area under curve (AUC).Comparisons of sizes, CEUS enhancement patterns, shape of TICs, quantitative CEUS parameters and serum tumor marker levels were conducted before and after HIFU treatment. Results A total of 19 patients were prospectively enrolled (10 women, 9 men；average age, 58.84±10.08 years). While comparing before and after HIFU treatment, no significant difference was observed on mean size of lesions, CEUS features or serum tumor markers.After HIFU treatment, TICs showed decreased enhancement, and AUC decreased either.Among all CEUS quantitative parameters, significant decrease could be found in PE ［(32 920.63±24 822.71) a. u vs. (17 296.11±16 570.41) a. u, P=0.001］and AUC［(624 665.28±593 711.71) a. u vs. (309 148.00±366 938.07) a. u, P=0.002]. Conclusion DCEUS may be a potential imaging method in detecting microvascular change of HIFU in patients with abdominal solid malignant tumor lesions.PE and AUC might be useful DCEUS quantitative parameters. [ABSTRACT FROM AUTHOR]

【目的】 观察慢性阻塞性肺疾病急性加重期（AECOPD）患者治疗前后气道内炎性介质与抗炎介质水平变化，阐明COPD气道局部炎症与气流受限的关系。【方法】 检测48例COPD急性加重期患者入院时（A1组）及治疗1周后（A2组）诱导痰肿瘤坏死因子γ（TNF-γ）和可溶性肿瘤坏死因子受体55、75（sTNF-R55、sTNF-R75）的水平并进行肺功能测定。以28例健康志愿者（吸烟者，B1组；不吸烟者，B2组）为对照组进行分析治疗前后炎症因子及肺功能变化。【结果】 AECOPD治疗前后诱导痰中TNF-γ和sTNF-R55、sTNFR75的水平均高于健康组（P

Objective To investigate the clinical value of contrast enhanced ultrasound （CEUS） before and after microwave ablation（MWA） of thyroid nodules. Methods In this prospective study， patients with thyroid nodules who planned to underwent ultrasound-guided MWA were included in Zhongshan Hospital，Fudan University from Jun 2016 to Aug 2020.CEUS was performed before and after MWA（1 day，1 month，3 months and 6 months）. The changes of microvascular perfusion and volume of thyroid nodules were observed and compared. Results Finally，a total of 94 patients were included，all lesions were confirmed by intraoperative ultrasound guided core needle biopsy and histopathological results. Final diagnosis included thyroid follicular adenoma （FA）（n=70） and papillary thyroid microcarcinoma （PTMC）（n=24）. Preoperative CEUS showed that most FA were hyperenhanced （37.14%） or isoenhanced（34.29%）during arterial phase of CEUS，while isoenhanced in venous phase and late phase. Meanwhile，most of PTMC（70.83%）showed typical hypoenhancement during arterial，venous and late phase of CEUS.Hyperenhanced rim around the lesions in the arterial phase of CEUS could be detected in 36 cases（51.43 %）of FA with an average thickness about（1.56±0.65）mm. Nonenhanced cystic areas could be detected in 33 cases （47.14%） of FA on CEUS. One day after ablation，CEUS showed no significant enhancement in 90 thyroid nodules（95.74%）. Compared with preoperation，the volume of FA and PTMC was significantly reduced（both P<0.05），and the volume reduction rate（VRR）was 67.25% and 40.45%，respectively. Conclusion Before MWA，CEUS is helpful to make accurate diagnosis of thyroid nodules and to determine the reasonable ablation area. After MWA，CEUS is useful to evaluate the therapeutic effect noninvasively and sensitively. [ABSTRACT FROM AUTHOR]

Copyright of Tunnel Construction / Suidao Jianshe (Zhong-Yingwen Ban) is the property of Tunnel Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【目的】比较不同时期慢性阻塞性肺病（COPD）患者诱导痰中细胞组成的变化，及其诱导痰中细胞成分尤其中性粒细胞百分比与气流受限的关系。【方法】对110例COPD患者[急性加重期COPD（AECOPD）患者（A1组）62例、稳定期COPD患者（B组）48例]及30例健康对照者（C组）进行肺功能测定及痰诱导，痰液处理后沉渣作细胞学分析。其中AECOPD组在治疗1周后（A2组）再次进行上述指标的测定。【结果】140例受试者中有21例因不能耐受痰诱导过程或痰标本不合格而退出研究，最终有119例受试者完成本研究（A。2组48例，B组43例，C组28例）。A，组、A2组、B组、C组诱导痰中细胞总数（106／mL）分别为（8．8±3．7）、（6．5±2．6）、（5．0±2．8）、（2．8±1．3），细胞分类中A。组、A2组、B组以中性粒细胞为主，分别为66％’15％、60％±10％、55％±11％，而在C组中则以巨噬细胞、中性粒细胞为主。分别为37％±10％、32％±8％；AECOPD患者（A1组、A2组）诱导痰中性粒细胞百分比与肺功能指标（FEV1、FEV1％pre、FVC、FEV1/FVC）呈负相关（r分别为-0．860、-0．682、-0．662、-0．300，P〈0．001）；稳定期组（B组）中性粒细胞与FEV1、FEV1％pre负相关（r分别为-0．346、-0．421，P〈0．05），对照组中性粒细胞与肺功能无相关性（P〉0．05）。【结论】AECOPD、缓解期、稳定期患者诱导痰细胞以中性粒细胞为主，健康者诱导痰细胞以巨噬细胞为主；气道局部中性粒细胞增多与各期COPD患者气流受限存在密切的关系。