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[目的]给予冠心病患者日常膳食中补充黑米米皮,评价其是否可以增强患者体内的抗氧化能力并降低其炎症及血脂水平。[方法]在中山大学附属第二医院心血管内科选取60例年龄为45～75岁的冠心病患者,采用随机对照原则将患者分入2组,30例在常规治疗的基础上每日膳食额外补充10g黑米米皮为干预组,余30例在常规治疗的基础上每日膳食额外补充10g白米米皮为对照组。此外,分别从干预组及对照组中选取3名志愿者,在受试者进食前和进食后0.5、1、1.5、2、4h采肘静脉血10mL,通过HPLC法检测患者血浆中的花色苷水平。[结果]经6个月的干预试验后,干预组患者血浆总抗氧化能力升高了（1.3±3.0）kU/L,而对照组则降低了（0.6±1.7）kU/L,两组间患者总抗氧化能力水平的变化值具有统计学差异（P〈0.05）;干预组患者治疗后血浆可溶性血管细胞粘附因子、可溶性CD40配体和高敏-C反应蛋白分别从（1.4±0.8）g/L、（8.4±4.1）mg/L和（3.8±1.8）mg/L降至（1.0±0.5）g/L、（5.7±2.4）mg/L和（2.6±1.7）mg/L,与对照组相比较均具有统计学差异（P〈0.05）;而两组患者间的血脂、超氧化物歧化酶活性水平的治疗效果无统计学差异。此外,只有在服用了黑米米皮患者血浆中能检测到花色苷（矢车菊素-3-葡萄糖苷）,其在血浆中的最高浓度为（20.2±3.0）mg/L出现在1.5h,而服用白米米皮的患者血浆中在所有的时间段都未检测到任何的花色苷产物。[结论]膳食补充黑米皮可以作为药物治疗的一种辅助和补充从而增强冠心病患者血浆中的抗氧化能力并改善部分与心血管疾病相关的危险因素,黑米皮对于冠心病患者的保护作用可能与其富含具有抗氧化和抗炎特性的花色苷类物质有关.

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Continuum robots have been widely used in natural cavity intervention therapy, but the current flexible continuum robots have poor positioning accuracy and lack of accurate navigation means. In response, a multi-segment continuum robot shape reconstruction method based on electromagnetic positioning information was proposed, aimed at achieving accurate end navigation and positioning. An efficient two-stage active structure shape reconstruction method based on third-order Bessel curve was proposed. The solution of Bessel curve was optimized to nonlinear least squares problem, which was solved quickly and accurately by particle swarm algorithm with linear decreasing weights. The proposed method can accurately fit the shape of the two-segment continuum and has good real-time performance. The results show that within the bending angle process, the average root-mean-square error of shape reconstruction is 0. 48 mm, which is 0. 8% of the length of the continuum bending segment. The accuracy and reliability of the proposed shape reconstruction method for intracavitary interventions using micro-continuum robots are demonstrated through detailed modeling and validation results. [ABSTRACT FROM AUTHOR]

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The various adsorbents were prepared separately to evaluate dye adsorption performance of common functional groups containing N or 0 atoms. The adsorption experiments of cationic methylene blue (MB) and anionic methyl orange ( MO) were conducted for different products. The results showed that cationic MB dye could only be adsorbed by products containing - COO or - 503, while anionic MO dye can only be adsorbed by products containing - N (CH3)3+. The other functional groups containing N or 0 atoms, including - OH, - CONH2, - NH2, C- 0- C, C=0, R3N, R1 -COO-R2, have no adsorption reaction to dyes. Furthermore, the adsorption mechanism has also been confirmed from charge conservation theory and mass transferring process. This study determined that electrostatic attraction is the only adsorption force to dyes, rather than hydrogen bond, which might give an insight to the future development of adsorbents. [ABSTRACT FROM AUTHOR]

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Carbon monoxide (CO) is a gaseous transmitter that has received mounting interest because of its therapeutic potentials in the treatment of inflammation, bacterial infection, cancer and so on. However, the clinical application of CO is remarkably hindered by the difficulty in precisely controlling CO concentrations and the targeted delivery of CO to pathological tissues. To circumvent these problems, CO-releasing molecules (CORMs) have been developed and widely used as the alternative of gaseous CO to explore the physiological functions of CO and develop novel therapeutic agents. Unfortunately, conventional CORMs suffered from insufficient stability, short half-life, and poor biodistribution in biological conditions. Intriguingly, the encapsulation of CORMs into polymeric nanoparticles or covalently installation of CORMs to polymeric matrices remarkably improves the stability of CORMs, prolongs the releasing time and optimizes the biodistributions. In this review, we summarize the recent achievements of CO-releasing macromolecules and highlight three approaches used for the fabrication of CO-releasing macromolecules. Also, we envision the potential applications of these macromolecular CO donors and suggest future directions in this field. We hope that more efforts would be devoted to this emerging field to advance the clinical trial of macromolecular CO donors. [ABSTRACT FROM AUTHOR]

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骨髓增生异常综合征(MDS)一般表现为大细胞或正细胞性贫血,该文报道伴三系病态造血的小细胞性贫血MDS 1例。该患者表现为小细胞性贫血,铁蛋白正常,血涂片可见10%的靶形红细胞;骨髓原始细胞低于5%,伴三系病态造血,环形铁粒幼细胞占6%;β地中海贫血基因突变;外周血SF3B1基因突变。该例患者诊断为β地中海贫血继发的伴环形铁粒幼细胞的多系病态造血MDS。提示小细胞性MDS在诊断时应考虑地中海贫血的继发或原发可能。 [ABSTRACT FROM AUTHOR]

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