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[Abstract] Objective To investigate the feasibility and value of histogram analysis based on two- dimensional gray-scale ultrasonography in the differential diagnosis of medullary thyroid carcinoma (MTC) and thyroid adenoma (TA). Methods The preoperative ultrasound images of 86 newly diagnosed MTC patients and 100 TA patients treated in the Cancer Hospital of Chinese Academy of Medical Sciences from January 2015 to October 2021 were collected. Histograms were performed based on the regions of interest (ROIs) delineated manually by two radiologists, thereafter, mean, variance, skewness, kurtosis, percentiles (1st, 10th, 50th, 90th, 99th) were generated. The histogram parameters between the MTC group and the TA group were compared, and the independent predictors were screened by multivariate logistic regression analysis. Receiver operating characteristic (ROC) analysis was used to compare the individual diagnostic efficacy and joint diagnostic efficacy of independent predictors. Results Multivariate regression analysis showed that mean, skewness, kurtosis and 50th percentile were independent factors. The skewness and kurtosis in the MTC group were significantly higher than those in the TA group, and the mean and 50th percentile were significantly lower than those in the TA group. The area under the individual ROC curve of mean, skewness, kurtosis and 50th percentile is 0.654-0.778. The area under the combined ROC curve is 0.826. Conclusion Histogram analysis based on two-dimensional gray-scale ultrasonography is a promising tool to distinguish MTC from TA, in which the joint diagnosis value of mean, skewness, kurtosis and 50th percentile is the highest. [ABSTRACT FROM AUTHOR]

The number of overtaking events is considered as an important indicator to measure the level of service of non-motorized vehicles and an important basis for calculating the conversion coefficient of non-motorized vehicles. Diversified non-motorized vehicles traffic flow data can be acquired for analysis through microscopic simulation. The traffic behavior of the overtaking vehicles was emphasized in the existing non-motorized vehicle social force model, whereas the influence of this behavior on the overtaken vehicles was currently ignored. Adjacent overtaking was taken as the research subject. The influence of the overtaking disturbance on the lateral shift distance of the overtaken vehicle was considered to improve the repulsive force between vehicles, and the effect of the space headway on the desire speed was considered to improve the driving force. The avoidance behavior of being laterally shifted and longitudinally dece-lerated by the overtaken vehicles was reproduced. The effectiveness of the model was verified by the speed-density diagram and the overtaking behavior. The number of overtaking events when the mixing ratio of electric bicycles is less than 25% is obtained by applying this simulation model, the non-motorized vehicles overtaking events model is established, and the corresponding non-motorized vehicles conversion coefficient is calculated to be 0.92. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the effects of simvastatin on tumor growth, blood coagulation in mice with colorectal cancer based on microRNA (miR)-181/ nuclear factor (NF)-κB pathway. METHODS: The colorectal cancer mice model was established by subcutaneous injection of human colorectal cancer cell line SW480, and 30 model mice were randomly divided into the control group, simvastatin low-dose group and simvastatin high-dose group. The simvastatin low-dose group and simvastatin high-dose group were intraperitoneally injected with 50 mg/ kg and 100 mg/ kg simvastatin, qd. On the 28th day, tumor growth, angiogenesis, coagulation indicators were analyzed. The expression levels of miR-181, IκBα and NF-κB mRNA and protein in tumor tissues were detected by quantitative reverse transcription polymerase chain reaction and western blotting. RESULTS: Compared with the control group, the tumor volume, mass, CyclinD1 protein, Ki67 protein, Bcl-2 protein, microvessel density, vascular endothelial growth factor (VEGF) levels, whole blood viscosity, IκBα and NF-κB mRNA and protein expression levels of the simvastatin low-dose group and simvastatin high-dose group decreased significantly, while Bax protein and miR-181 levels increased, plasma prothrombin time ( PT), activated partial thromboplastin time ( APTT) and miR-181 were prolonged significantly, with statistically significant differences ( P < 0. 05 ). The tumor volume, mass and microvascular density in simvastatin high-dose group were significantly lower than those in simvastatin low-dose group [(171. 74±19. 33) mm3 vs. (226. 52±26. 38) mm3, (0. 21±0. 03) g vs. (0. 28±0. 04)g, (9. 77±1. 85)% vs. (16. 39±2. 11)%], CyclinD1, Ki67 and Bcl-2 protein levels, VEGF levels, whole blood viscosity, expression levels of IκBα and NF-κB mRNA and protein were significantly lower than those in simvastatin low-dose group; the levels of Bax protein and miR-181 were significantly higher than those of simvastatin low-dose group, PT and APTT were significantly longer than those of simvastatin low-dose group, the differences were statistically significant (P<0. 05). CONCLUSIONS: Simvastatin may inhibit tumor growth and angiogenesis in colorectal cancer model mice by regulating the miR-181/ NF-κB pathway, and alleviate blood hypercoagulability. [ABSTRACT FROM AUTHOR]

Background——Analyzing the spatial differentiation characteristics of the competitiveness of China’s panel industry and the factors restricting the development of China’s panel industry are of great significance for promoting the rational planning of the spatial layout of China’s wood-based panel industry and achieving high-efficiency development. Methods——Firstly, the entropy method is used to evaluate the competitiveness of China’s wood-based panel industry comprehensively. Secondly, the author embeds the results of the competitiveness measurement of the wood-based panel industry into the vector diagram to analyze the spatial pattern evolution and regional differentiation characteristics of the competitiveness of the wood-based panel industry. Finally, the principal component analysis method is used to extract the key impact indicators, and the regression model is used to estimate the driving effect of key factors on the competitiveness of the wood-based panel industry. Results——From 2010 to 2019,the overall regional distribution of the competitiveness of the wood-based panel industry is strong in the east and weak in the west, strong in the south and weak in the north. The areas with medium and high competitiveness are mainly distributed in East China, South China and Southwest China. Among them, 16 provinces are at a relatively low level of competitiveness. The proportion of provinces and cities with high level of competitiveness in the wood-based panel industry is only 11.54%,and the proportion of provinces and cities with low and medium levels and below is as high as 61.54%.The number of invention patents, forestry fixed asset investment, plantation area, annual average wages of employees in forestry manufacturing industry, railway network density, regional GDP per capital, and urbanization rate have a positive effect on the competitiveness of the wood-based panel industry, while the number of R&D funds, the number of R&D personnel and the export value of goods have a negative effect on the competitiveness of the wood-based panel industry. Conclusions and Discussions——Under the background of the promotion of the double-cycle strategy, it is emphasized that the development of the wood-based panel industry should take the internal circulation as the main body, and emphasize that relying on the local advantages of the industry to form the backbone of the domestic market of the wood-based panel industry, to achieve the overall improvement of competitiveness. Starting from the strategic point of the country’s adherence to expanding domestic demand, the specific recommendations are suggested as follows: First, advanced production factors, internal demand and industrial strength are important supports for the competitiveness of the wood-based panel industry. Second, the regional distribution of China’s wood-based panel industry competitiveness is uneven and the overall stability is at a relatively low level. Third, the driving factors of the competitiveness of the wood-based panel industry lie in many aspects, among which the positive driving effect of the annual average salary of the employees in the forestry system manufacturing industry is the most significant. The specific recommendations are as follows: We should balance the central and western regions and take it as the main direction to consolidate and optimize the domestic circulation. It is necessary to focus on the development of neighboring provinces and at the same time, the high-tier teams will lead and drive the development of low-tier teams. Then, attention must be paid to the investment of R&D funds, the introduction and training of R&D talents, which can ensure the effective transformation of R&D results. Next, the traditional fixed asset investment projects of the wood-based panel industry need to be adjusted, and should integrate and update with new technologies constantly. Finally, we can provide employees with a complete social life security and pay attention to employees’ training. [ABSTRACT FROM AUTHOR]

Aiming at the uncertainty in the process of landslide hazard evaluation along the railway, game theory and cloud model evaluation methods were introduced, and Hamming distance was used to verify the similarity comparison results to evaluate the landslide hazard along the railway. Firstly, 12 influencing factors such as rainfall, stratigraphic lithology and land use type were selected to establish the risk evaluation index system. Secondly, the improved CRITIC method, coefficient of variation method, G1 method and order diagram method were adopted to determine the basic weight. Then the game theory is introduced to calculate the optimal weight, and the comprehensive evaluation cloud is determined according to the cloud model and the optimal weight of each evaluation index. Finally, the Hamming distance is used to verify the similarity comparison results of the comprehensive evaluation cloud and the evaluation standard cloud, and the landslide risk grade is determined according to the maximum similarity principle, and the landslide risk distribution map of the study area is generated based on ArcGIS. The results show that the landslide hazard grade is level four, which is basically consistent with the actual situation. The landslide hazard evaluation model based on game theory and cloud model can accurately reflect the grade of landslide. The cloud model is used to realize the conversion of qualitative and quantitative problems, which makes the landslide hazard level more intuitive and has certain reference value for landslide hazard risk management. [ABSTRACT FROM AUTHOR]

State-owned forest areas play a pivotal role in China's forestry construction and development. The construction of state-owned forest areas has always unswervingly implemented the development strategy of the Communist Party of China and the country. This article analyzes the achievements of the state-owned forest area construction based on the long-term survey data of the state-owned forest area. The purpose of reviewing the construction experience of state-owned forest areas is to better explore the market-oriented ways for state-owned forest resources to obtain ecological benefits under the new situation, so that forestry can play its main function in ecological construction and make forest resources a valuable asset for the whole nation. These measures help to better serve the implementation of the national strategy, adapt to and meet the needs of diversified social interests to the greatest extent, and realize the sustainable development of the whole nation. This article separately discusses the development policy of state-owned forest resources in four stages. The first stage is before and after the founding of the People's Republic of China. The forest resource is weak and the production capacity is low, and the demand of wood for the recovery and development of the national economy is rapidly expanding, and the problem of shortage of supply needs to be solved urgently. For this reason, the policy with the protection and development of forest resources as the main body has laid the general tone of forestry construction. The second stage is before the Reform and Opening up. Due to the low level of China's economic development, the driving force of economic development mainly depends on the massive investment of resources. Therefore, in order to meet the demand for timber for large-scale infrastructure construction, the focus of state-owned forest management and construction is to increase the timber output of forest industry enterprises in state-owned forest areas, expand subsequent forest farm construction in forest areas, promote the cultivation and management of forest resources, and develop new forest areas. etc. The third stage includes twenty years after the Reform and Opening up. At this stage, specific operation and management measures were put forward, such as rectifying the enterprise, improving rules and regulations, etc. A series of measures have made the company's overall business objectives and annual plans better realized, and played an important role in guaranteeing the social stability of forest areas. The fourth stage is the period of comprehensive transformation and development of state-owned forests. The policy clearly pointed out that the main business direction of forest industry enterprises is to turn logging into forest management and to stop logging of natural forests in a planned way, marking a major adjustment of China's forestry development strategy. The ecological functions of state-owned forest areas have been improved, and the living environment of wild animals has also been improved accordingly. At the same time, these measures have led to the initial results of the economic transformation and development of forest areas, which are manifested in social stability, the lives of workers and the masses have been guaranteed in many aspects, the quality of life of residents has been improved, and the livelihood and welfare of the people in the jurisdiction have been significantly improved. In summary, in the process of the development and utilization of China's state-owned forest resources, state-owned forest areas closely follow China's economic and social development strategy. From expanding production, serving politics, providing primitive accumulation to reducing timber output, stopping logging, and protecting natural forests, providing ecological products. And then implement the goal of ecological civilization construction, to serve the realization of the "double carbon" goal, and always unswervingly implement the party and the country's development strategy and goals. The achievements made in the construction of state-owned forest areas are the inevitable result of the Communist Party of China's long-standing adherence to respecting, conforming to, and protecting nature, insisting that Chinese society must follow the path of sustainable development, and constantly adjusting and improving state-owned forest management policies. Based on this, state-owned forest industry enterprises should be actively explored to become a public welfare operation mode and a new way to effectively restore natural forest resources in order to provide more ecological products and better implement the Party Central Committee's strategy of ecological civilization construction. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between high-density lipoprotein cholesterol (HDL-C) and the prognosis of alcohol-related hepatocellular carcinoma (HCC) patients after radical treatment. Methods Retrospective analysis of the Fifth Medicine of PLA General Hospital from January 2008 to July 2015 The clinical data of 43 alcohol-related HCC patients who received radical treatment in the center were divided into normal group (n=26) and abnormal group (n=17) according to the level of HDL-C. Comparison of basic information and laboratory between the two groups Differences in test indicators, imaging-related indicators, tumor BCLC staging, and liver function Child-Pugh classification. Measurement data that conforms to the normal distribution are compared between the 2 groups by t test, and measurement data that does not conform to the normal distribution are compared between the 2 groups by Mann -Whithey U test; χ2 test was used for comparison of enumeration data between 2 groups. Survival curve was drawn by Kaplan-Meier method, and log-rank test was used for comparison between groups. Univariate and multivariate Cox proportional hazard models were used to explore independent risk factors related to prognosis. Results There was a statistically significant difference in prealbumin between the two groups [(162.38±60.86)mg/L vs (120.06±64.08)mg/L, t=2.184, P=0.035]; the number of tumors (HR=2.839, 95% CI: 1.120～7.200, P=0.028), tumor size (HR=2.634, 95%CI: 1.062～6.529, P=0.037) and HDL-C level (HR=2.400, 95%CI: 1.040～5.537, P= 0.040) is an independent risk factor affecting the overall survival of patients with alcohol-related HCC. The 1, 3, and 5-year cumulative survival rates of the HDL-C normal group were 88.5%, 72.4%, and 55.7%, respectively, and the HDL-C abnormal group were respectively 70.6%, 43.7%, 17.5%, the difference in cumulative survival rate between the two groups was statistically significant (χ2=5.881, P=0.015). Conclusion The reduction of HDL-C level may indicate a poor prognosis for patients with alcohol-related HCC. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of doxorubicin（Dox）on pyroptosis of cardiomyocytes，and to explore its relationship with Caspase-3/GSMDE（GSDME）pathway. Methods Rat cardiomyocytes H9c2 were divided into four groups. The cells in the blank control group were added with culture medium；the cells in the Dox group were treated with 4 μmol/L Dox for 8 h；the cells in the GSDME transfection control group were transfected with GSDME siRNA control without interference sequence；the cells in the GSDME interference group were transfected with GSDME siRNA and then were added with Dox and cultured for 8 h. Propidium iodide（PI）staining method was used to observe pyroptosis（PI-positive cell rate)，and colorimetry and ELISA were used to detect LDH，IL-1β，IL-18 released into the supernatant after cell injury，and Western blotting was used to detect Cleaved Caspase-3 and GSDME-N（GSDME was cleaved by Cleaved Caspase- 3 to form a cell pore-forming fragment）and inflammation-related proteins IL-1β and IL-18. Results Compared with the blank control group，the rate of PI positive cells increased，the release of LDH，IL-1β，and IL-18 in the cells increased， and the expression of Cleaved Caspase-3，GSDME-N，IL-1β，and IL-18 protein increased in the Dox group and the GSDME transfection control group（all P<0. 05). Compared with the Dox group，the rate of PI positive cells，the release of LDH，IL-1β，IL-18 and the expression of GSDME-N protein in the GSDME interference group decreased（all P<0. 05)， and there were no statistical differences in the indicators of the GSDME transfection control group. Conclusion Dox can induce pyroptosis of cardiomyocytes through Caspase-3/GSDME pathway，and lead to myocardial injury. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of Shunaoxin dropping pills (SNX)on the meningeal microcirculation disturbance in rats. Methods Wistar rats (70 cases)were randomly divided into the control group,model group,13 mg/ kg SNX group,26 mg/ kg SNX group,52 mg/ kg SNX group,Naoxintong capsule group,and nimodipine group. Rats were administrated continuously for 7 days,once daily. One hour after the last administration,the rats were injected with 15% high molecular weight dextran 5 mL/ kg to prepare the cerebral microcirculation disturbance models. The blood flow on the surface of the dura mater was monitored at different time points in each group,and the levels of plasma NO and ET-1 were measured. Results Compared with the control group,the meningeal microcirculation blood flow decreased at 5 to 120 minutes after the injection of 15% high molecular weight dextran in the model group (all P < 0. 01). Compared with the model group,cerebral pia mater meningeal blood flow increased in the 26 mg/ kg SNX group and 52 mg/ kg SNX group at 5 to 120 minutes after modeling (P <0. 05 or P <0. 01). In the 52 mg/ kg SNX group,the plasma endothelial factor NO level increased,and the ET-1 concentration decreased (P <0. 05 or P <0. 01). The effect of SNX (52 mg/ kg)is equivalent to the effect of Naoxintong capsule and nimodipine in the clinically equivalent doses. Conclusion SNX can improve cerebral microcirculation disturbance in rats. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effect of selective auriculotemporal nerve block(ANB)on postoperative analgesia after the operation of ROSA robot assisted intracranial electrode implantation. Methods Sixty patients with the application of ROSA robot assisted intracranial electrode implantation， aged 13-65 years old，16

要：随着冠状动脉造影的普及， 临床发现部分急性心肌梗死的患者并无明显的冠状动脉阻塞（ 冠状动脉狭窄 程度 < 50% ） ，这类心肌梗死被定义为冠状动脉非阻塞性心肌梗死( MINOCA) ，在急性心肌梗死中约占 10% 。 不 同 于阻塞性心肌梗死的发病特点 ，MINOCA 的发病主要与斑块破裂、冠状动脉痉挛、冠状动脉微循环璋碍、冠状动脉 夹层等原因有关，通常较少合并血脂异常、糖尿病、高血压、吸烟等传统危险因素 ， 因此血运重建不是 MINOCA 患者 的首选治疗措施。 目前临床上应用于 MINOCA 的药物主要有 B 受体阻滞剂、钙离子拈抗剂、硝酸酣类等，大多与阻 塞性心肌梗死相似 ，但具体治疗效果及预后仍无明确定论。 能否尽早识别 MINOCA， 寻找潜在原因并给予有效的 干预措施与预后紧密相关。 [ABSTRACT FROM AUTHOR]

The effects of spray adjuvants on physical properties of two insecticides and the synergistic effects against Paracoccus marginatus were investigated in this study. The effects of surface tension, expanded diameter, maximum retention on spirodiclofen 240 g/L suspension concentrate(SC) and pyridaben 15% emulsifiable concentrate(EC) were determined under indoor conditions after the addition of five spray adjuvants (aloe essential oil, silicone silwet408, JFC-2, azone and PBO). In addition, the synergistic effect between the adjuvants and two insecticides were evaluated. The results indicated that the spray adjuvants can significantly reduce the surface tension, increase the expansion diameter, retention and indoor virulence. Spray adjuvants can increase the indoor virulence of spirodiclofen 240 g/L SC and pyridaben 15% EC by 5.1%-26.1% and 22.7%-41.8%, respectively. JFC-2 and PBO were more effective for the increase of the synergistic effects with spirodiclofen 240 g/L SC and pyridaben 15% EC. Field experiments showed that JFC-2 and PBO improved the field control effect of two insecticides in different concentrations against P. marginatus, especially for that in high concentrations. The synergistic effect between JFC-2 and spirodiclofen 240 g/L SC was 10.3%-24.6%, and that between PBO and pyridaben 15% EC was 12.1%-28.9%. [ABSTRACT FROM AUTHOR]

目的对乳腺癌术后患者运用基于格林模式的健康最育方式,分析其对乳腺癌术后患者功能锻炼依从性的影响。 方法选取2019年 9 11 月于陆军军医大学大坪医院乳烘甲状腺外科行乳踩癌根治术的40例患者,将其随机分为试验组(20 例)与对照组(20例),试验组运用基于格林模式的健康教育方法,对照组给予常规健康教育方法。结果试验组患者功能假炼总 依从率[100.0%(20/20)高于对照组[80.0%(16/20左异有烷计学意义(P<0.05),试验组患者术后 40d日常生活质量评分 [(98.5±2.7分]高于对照组(92.0+2.9分,差异有统计学意义(P-0.05)认验组患者肩关节活动度明显大于对照组,差异有 统计学意义(P<0.05)。结论对乳腺癌术后患者运用基于格林模式的健康教育方式,能有效提高其功能假炼的依从性、肩关节活 动度及其生活质量。 [ABSTRACT FROM AUTHOR]

For mobile LiDAR point cloud data, a new hybrid index structure combining global KD-tree and local Octree is proposed to improve the efficiency of data organization and management, which is named as KD-OcTree index. Firstly, global KD-tree reconstructs the spatial neighborhood relations by defining the segmenting dimension and segmenting planes, for the purpose of ensuring the balance of the whole index. Then, local Octree is constructed in the leafs of KD-tree, which can avoid some shortcomings such as the unbalance of point cloud distribution, deeper Octree, large amount of non-point space, and so on. Lastly, we take three real scenes' point clouds as test data to process. The experimental results and comparative analysis show that the KD-OcTree index can not only improve the speed of constructing index and neighborhood searching, but also improve the effect of data-processing and influence the reliability of classification. [ABSTRACT FROM AUTHOR]

The unexplained recurrent miscarriage is a research hotspot in the worldwide medicine, and the immune factors of recurrent abortion have been presently focused. The complement system, as an important component of innate immunity, plays a complex and delicate role in pregnancy. A certain extent of activation of complement components is necessary for the normal development of the fetus and pregnancy appendages during pregnancy. The excessive activation of complement system on the maternal fetal interface can lead to embryo loss by the multiple mechanisms of placental development defect, inflammatory injury, and disorder of specific cellular immune. Therefore, dysfunction or excessive activation of the complement system is a risk factor for recurrent miscarriage. In this review, we reviewed the study progress of complement system in normal pregnancy and recurrent spontaneous abortion, in order to provide a feasible reference for the immunotherapy of recurrent miscarriage. [ABSTRACT FROM AUTHOR]

口服抗凝药物（NOACs)抗凝效果好，且对正常的凝血级联反应几乎没有影响，仅有很小的内源性促凝血 和抗凝血生物活性。但是，由于缺乏有效的措抗剂，NOACs在使用过程中受到很大的限制。Andexanelalfa是美国 Pmlola医药公司开发的一种重组凝血因子Xa(FXa)诱导分子，与天然的FXa类似，可竞争性抑制直接和间接FXa 抑制剂，有希望成为广谱的针对FXa抑制剂类药物的解毒剂。目前，临床前和临床试验已经初步证实 Andexanel alfa可抑制直接和间接FXa抑制剂活性，且具有良好的使用安全性。 [ABSTRACT FROM AUTHOR]

Biomass carbon density is one of the important features of carbon sequestration ability in ecological system. To describe the characteristics of biomass carbon density in alpine grassland in the “Three-River Headwaters” region, above ground biomass, living root biomass, dead root biomass and their carbon content in black soil land and natural grassland were measured. The results showed that the aboveground biomass in black soil land was higher than the aboveground biomass in degraded artificial grassland and natural grassland; but the living root biomass and dead root biomass in black soil land were lower than the living root biomass in degraded artificial grassland and natural grassland. The total biomass carbon density in degraded artificial grassland, black soil land and natural grassland was 719.47, 706.57 and 2 233.09 g/m2, respectively. Grassland degradation not only changed ecosystem biomass allocation, but also changed the carbon density distribution in aboveground vegetation, living roots and dead roots. Root carbon density in degraded artificial grassland and natural grassland accounted for more than 90% of the total biomass carbon density, while the roots carbon density in black soil land accounted for 79.41%. The variation of carbon density in living roots was greater than those in aboveground vegetation and dead roots among three types of grassland, therefore, we initially considered that living roots carbon density may be a sensitive indicator of grassland degradation. [ABSTRACT FROM AUTHOR]

Tenghuangjiangu capsules (TJC) can improve bone microstructural damage by increasing bone mineral density in postmenopausal osteoporosis model rats, but the specific mechanism has not been clarified. In this study, the effects of TJC on osteoblast apoptosis and SIRT1/PGC-1α/Nrf2 signaling pathway in postmenopausal osteoporosis rats were studied, in order to explore the mechanism of TJC on postmenopausal osteoporosis. The postmenopausal osteoporosis rat model was established using the ovariectomized method. TJC (0.09 g/kg, 0.18 g/kg, 0.36 g/kg) were given by intragastric administration, and the indices were detected after 8 weeks of continuous intervention. The apoptosis of femur tissue was observed by TUNEL staining. The results showed that the number of positive cells and rate of apoptosis of femur tissue decreased in each dose group (P<0.01). The expression of SIRT1, PGC-1α and Nrf2expression level in osteoblasts of femoral tissue was observed by double immunofluorescence staining. The fluorescent area of PGC-1α expression in osteoblasts in high dose increased significantly, and the fluorescent area of SIRT1 and Nrf2 expression in osteoblasts in each dose also increased significantly (P<0.01). Detection of SIRT1, PGC-1α, Nrf2, Runx2, Bcl-2, Caspase-3 and Caspase-9 in femoral tissue by qPCR and Western blotting. The expression of Runx2 mRNA level and translation level, the expression of Nrf2 translation level were significantlyincreased, and the expression of Caspase-9 translation level were significantly decreasedin the middle and high-dose groups of TJC. The expression of SIRT1, PGC-1α, Bcl-2 mRNA level and translation level, and the expression of Nrf2 mRNA level were also significantly increased at each dose, while the expression of Caspase-3mRNA level and translation level were significantly decreased,and the expression of Caspase-9 mRNA level were significantly decreasedat each dose (P<0.01). Thus, this study preliminarily revealed that the inhibition of osteoblast apoptosis in postmenopausal osteoporosis model rats by TJC involves the SIRT1/PGC-1α/Nrf2 signaling pathway, and SIRT1 may be an important target for regulating osteoblast apoptosis. [ABSTRACT FROM AUTHOR]

A 4th-order entropy stable semi-discrete finite volume scheme was constructed for ideal magnetohydrodynamic equations. This scheme combines the high-order entropy conservative flux with the dissipation term reconstructed with the WENO scheme in the spatial direction. With a switching function added to the dissipation term, the numerical flux has lower dissipation and the WENO reconstruction satisfies the sign property. The source term used to control the divergence of the magnetic field is discretized with the center difference scheme to obtain high-order accuracy consistent with the entropy conservative flux. Several 1D and 2D cases show that, the scheme has no oscillation and strong robustness, and can accurately capture discontinuities. [ABSTRACT FROM AUTHOR]

AIM: To investigate the effect of Tenghuang-Jiangu capsule （TJC） on the expression of silent information regulator 1（ SIRT1）/nuclear factor κB（ NF-κB）/nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） signaling pathway in postmenopausal rats with osteoporosis and its molecular mechanism. METHODS: Female Sprague-Dawley rats were randomly divided into sham group, model group ［ovariectomy （OVX） group］, SIRT1 inhibitor （EX-527）+OVX group, positive control estradiol valerate （ESV）+OVX group, and high-, medium- and low-dose TJC groups （TJC-H+OVX, TJC-M+OVX and TJC-M+OVX groups）, with 10 rats in each group. The TJC, ESV or EX-527 intervention after OVX was performed. Double immunofluorescence staining was used to detect SIRT1, NF-κB p65 and NLRP3 proteins, and ELISA was performed to detect inflammatory factors. RT-qPCR and Western blot were used to detect the mRNA and protein expression of SIRT1/NF-κB/NLRP3 signaling pathway-related molecules and osteoclast differentiation markers. RESULTS: Compared with sham group, serum levels of interleukin-1β（ IL-1β）, IL-18, and tumor necrosis factor-α （TNF-α） increased significantly in the OVX model group and in SIRT1 inhibitor EX-527 group （P<0. 01）. Similarly, the fluorescence area of NF-κB p65 and NLRP3 in osteoclast（ P<0. 01）, and the mRNA and protein expression levels of NF-κB p65, NLRP3, and activated T cell c1 nuclear factor cytoplasmic 1 （NFATc1） in the femur also increased significantly （P<0. 01）. However, the fluorescence area of SIRT1 in osteoclast decreased significantly in the OVX model group and in SIRT1 inhibitor EX-527 group（ P<0. 01）. Compared with OVX group, serum IL-1β content and NLRP3 protein expression level in the femur in the TJC-H treatment group decreased significantly. A similar decrease was observed for the serum IL-18 content, NF-κB p65 and NFATc1 protein expression levels in the femur in the TJC-H and TJC-M group rats. Serum TNF-α content, NF-κB p65 and NLRP3 expression fluorescence area in osteoclast, NF-κB p65, NLRP3, and NFATc1 mRNA expression levels in the femur decreased significantly in the TJC-H, TJC-M, and TJC-L groups. In contrast, the fluorescence area of SIRT1 in osteoclast increased significantly （P<0. 05）. Compared with EX-527+OVX group, NLRP3 protein expression level in the TJC-H treatment group decreased significantly. Serum IL-1β content in the TJC-H and TJC-M treatment group decreased significantly. A similar decrease was observed for the serum IL-18 content, NF-κB p65 and NFATc1 protein expression levels in the femur in the TJC-H and TJC-M groups. Serum TNF-α content, NF-κB p65 and NLRP3 expression fluorescence area in osteoclast, NF-κB p65, NLRP3, and NFATc1 mRNA expression levels in the femur decreased significantly in the TJC-H, TJC-M, and TJC-L treatment groups, in contrast, the fluorescence area of SIRT1 in osteoclast increased significantly （P<0. 05）. CONCLUSION: Tenghuang-Jiangu capsule can inhibit osteoclast differentiation in postmenopausal osteoporosis model rats. The mechanism may be related to the inhibition of SIRT1/NF-κB/NLRP3 signaling pathway activation and alleviation of inflammatory response. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between abnormal chromosome of amniotic fluid cells and the prenatal diagnosis. Methods: 466 cases of high-risk pregnant women underwent amniocentesis were selected as objects. The amniotic fluid cells were cultured and chromosome was analyzed. Results: Abnormal chromosome in 66 cases, the abnormal rate was 14.16 %, including the number of chromosome abnormalities in 27 cases, 22 cases of trisomy syndrome (15 cases, 6 cases and 1 cases of trisomy 21, trisomy 18 and trisomy 13), accounting for 33.33 % of the total abnormal chromosome, 81.48 % of the number abnormality of chromosome; chromosome structural abnormalities in 39 cases, including chromosome polymorphism, translocation, inversion and other derivatives, accounting for abnormal chromosome 59.10 %. The detection rate of abnormal chromosome in serological screening of high risk group (14.44 %) was higher than that of older pregnancy group (10.89 %) and a history of adverse pregnancy group (11.11 %) （P<0.05）; and the detection rate in ultrasound fetal abnormality group (23.26 %) was higher than that of serum screening for high-risk groups（P<0.05）. Conclusion: Serum and ultrasound screening for high-risk fetal abnormalities is the main area of Heilongjiang prenatal diagnosis indications, abnormal chromosome with trisomy 21-syndrome is the highest. The chromosome analysis of amniotic fluid cell of high-risk pregnant women can be found in the chromosome diseases, so as to avoid the child birth defects. [ABSTRACT FROM AUTHOR]

In the study of carbonaceous aerosols, researchers found that not only black carbon (BC) exists in the atmosphere, but also some organic carbon (OC) in the ultraviolet-visible wavelength band, and the absorbing part is also called brown carbon (BrC) because of its brown or tan color. Based on the existing research, the sources, chemical composition and optical characteristics of BrC in atmospheric particulate matter are reviewed to obtain the differences in the optical characteristics of BrC under different sources. From the source point of view, BrC is mainly divided into primary source and secondary source, different sources of BrC optical characteristics are also different, fossil fuel source BrC light absorption capacity is stronger than biomass combustion source BrC, and has a higher wavelength dependence; from the perspective of chromophores, water-soluble and water-insoluble BrC identified chromophores are mainly humic-like substances, polycyclic aromatic hydrocarbons, proteins and nitro aromatic compounds, etc. Chromophores are considered the key to determine the light absorption characteristics of BrC, which contribute about 30%～70% to the absorbance of light in the 300～400 nm band. Finally, the problems existing in BrC research and future research directions are discussed, and the research trends and prospects of BrC in optics are prospected. [ABSTRACT FROM AUTHOR]

疫苗接种是预防传染病的有效手段，经皮免疫(TCI)属于无针接种，微针是 TCI 中发展较迅速的一种。 微针已在病毒疫苗、DNA 疫苗及细菌疫苗接种等方面开展研究，发现其在免疫效果、疫苗稳定性及节省剂量等方面有较大优势，具有广阔的市场前景，但是目前尚无上市销售的微针疫苗产品。随着微针技术的发展和临床研究的不断深入，微针接种将成为未来 TCI 的新方式之一。 [ABSTRACT FROM AUTHOR]

目的观察CALLISPHERES®载药微球联合支气管动脉化疗药物灌注治疗晚期非小细胞肺癌的疗效及 安全性。方法非小细胞肺癌患者23例（观察组），接受CALLISPHERES®载药微球（表柔比星80 mg）联合支气管动 脉化疗药物（腺癌患者使用注射用培美曲塞二钠500 mg/m2 + 卡铂300 mg/m²，1次/21 d；鳞状细胞癌患者使用吉西 他滨1 000 mg/m2 + 卡铂300 mg/m²，1次/21 d）灌注治疗；非小细胞肺癌患者21例（对照组），行传统化疗（腺癌患者 予以“注射用培美曲塞二钠500 mg/m2 + 卡铂300 mg/m2，1 次/21 d”全身化疗；鳞状细胞癌患者使用“吉西他滨 1 000 mg/m² + 卡铂300 mg/m²，1次/21 d”全身化疗）。治疗2、4、6个月时，计算两组的客观缓解率（ORR）、疾病控制 率（DCR）。随访3年，记录患者疾病无进展生存期（PFS）、总生存期（OS）、中位生存期（MST）。结果治疗4、6个月 时，观察组与对照组ORR比较，P 均< 0. 05；两组DCR比较，P 均>0. 05。观察组PFS、OS、MST均长于对照组（P 均< 0. 05）；病理类型为腺癌的患者中，观察组与对照组PFS、OS、MST比较，P 均<0. 05；病理类型为鳞癌的患者中，观察 组与对照组PFS、OS、MST比较，P 均>0. 05。两组不良反应较轻微，可自行缓解或对症治疗后症状很快缓解，患者均 未出现严重并发症。结论CALLISPHERES®载药微球联合支气管动脉化疗药物灌注治疗晚期非小细胞肺癌疗效 好、优于传统化疗，且安全性高。 [ABSTRACT FROM AUTHOR]

The mortality rate of the acute lymphocyte disease is extremely high, and CAR-T cell immunotherapy provides a new choice. This paper introduced a refractory acute B-lymphoblastic leukemia (B-ALL) patient with TP53 positive mutation and short-term recurrence after remission from CD19 CAR-T therapy. The case was successfully treated by CD22 CAR-T combined with allogeneic hematopoietic stem cell transplantation. The proportions of peripheral blood CD19 CAR-T and CD22 CAR-T cells were analyzed by flow cytometry. The expression of CAR gene in peripheral blood was detected by PCR method. The efficacy and the side effects of CD19 CAR-T and CD22 CAR-T therapy were observed in this patient. The CD19 CAR-T and CD22 CAR-T cell treatments both achieved complete remission on the day 14, and the side effects were minor. But bone marrow recurrence 2 weeks after remission from CD19 CAR-T cell therapy with abnormal 19 CAR gene expression in peripheral blood and increased TP53 mutation level. The patient was successfully treated with CD22 CAR-T cells bridged with haploid hematopoietic stem cell transplantation therapy. In a word, the purity of CD3+ cells should be further improved in the process of CAR-T cell manufacture. CD22 CAR-T therapy could be used as a salvage measures for the patient with relapse of CD19 CAR-T therapy. [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ　Ｔｏ ｃｏｍｐａｒｅ ｔｈｅ ｅｆｆｉｃｉｅｎｃｙ ｏｆ ｓａｌｉｎｅ ｉｒｒｉｇａｔｉｏｎ， ａｎｔｉｂｉｏｔｉｃｓ ｉｒｒｉｇａｔｉｏｎ ａｎｄ ｈｉｇｈ⁃ ｃｏｎｃｅｎｔｒａｔｉｏｎ ａｎｔｉｂｉｏｔｉｃｓ ｐｅｒｆｕｓｉｏｎ ｗｉｔｈ ｔｕｂｅ ｄｒａｉｎａｇｅ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｉｎｆｅｃｔｉｏｕｓ ｅｆｆｕｓｉｏｎ． Ｍｅｔｈｏｄｓ　Ｃｌｉｎｉｃａｌ ａｎｄ ｓｏｎｏｇｒａｐｈｉｃ ｆｅａｔｕｒｅｓ ｏｆ ａｂｄｏｍｉｎａｌ ａｎｄ ｐｅｌｖｉｃ ｉｎｆｅｃｔｉｏｕｓ ｅｆｆｕｓｉｏｎ ｏｆ ６４ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｍａｌｉｇｎａｎｔ ｔｕｍｏｒ ｃｏｌｌｅｃｔｅｄ ｆｒｏｍ Ｓｅｐｔｅｍｂｅｒ ２０１３ ｔｏ Ｓｅｐｔｅｍｂｅｒ ２０１７ ｗｅｒｅ ｒｅｔｒｏｓｐｅｃｔｉｖｅｌｙ ａｎａｌｙｚｅｄ． Ｔｈｅ ｃｈａｎｇｅｓ ｏｆ ｅｆｆｕｓｉｏｎ ｓｉｚｅ ａｎｄ ｔｅｍｐｅｒａｔｕｒｅ， ｃａｔｈｅｔｅｒｉｚａｔｉｏｎ ｔｉｍｅ ｗｅｒｅ ｅｖａｌｕａｔｅｄ ｉｎ ｓａｌｉｎｅ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ ａｎｄ ａｎｔｉｂｉｏｔｉｃｓ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ． Ｔｈｅ ｃａｔｈｅｔｅｒｉｚａｔｉｏｎ ｔｉｍｅ ｗａｓ ｃｏｍｐａｒｅｄ ｂｅｔｗｅｅｎ ａｎｔｉｂｉｏｔｉｃｓ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ ａｎｄ ｈｉｇｈ⁃ｃｏｎｃｅｎｔｒａｔｉｏｎ ａｎｔｉｂｉｏｔｉｃｓ ｐｅｒｆｕｓｉｏｎ ｇｒｏｕｐ． Ｒｅｓｕｌｔｓ　Ｔｈｅ ｅｆｆｅｃｔｉｖｅ ｒａｔｅｓ ｏｆ ｔｈｅ ｓａｌｉｎｅ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ ａｎｄ ｔｈｅ ａｎｔｉｂｉｏｔｉｃｓ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ ｗｅｒｅ ６８．６％ ａｎｄ ８６．８％， ｒｅｓｐｅｃｔｉｖｅｌｙ， ａｎｄ ｔｈｅ ｔｉｍｅｓ ｏｆ ｃａｔｈｅｔｅｒｉｚａｔｉｏｎ ｗｅｒｅ １１．９±８．４ ｄａｙｓ ａｎｄ ７．８± ４．８ ｄａｙｓ， ｒｅｓｐｅｃｔｉｖｅｌｙ， ｗｉｔｈ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｓｔａｔｉｓｔｉｃａｌ ｄｉｆｆｅｒｅｎｃｅ （ｂｏｔｈ Ｐ ＜ ０．０５）． Ｈｏｗｅｖｅｒ， ｔｈｅ ｅｆｆｅｃｔｉｖｅ ｒａｔｅｓ ｏｆ ｔｈｅ ａｎｔｉｂｉｏｔｉｃｓ ｉｒｒｉｇａｔｉｏｎ ｇｒｏｕｐ ａｎｄ ｔｈｅ ｈｉｇｈ ｃｏｎｃｅｎｔｒａｔｉｏｎ ａｎｔｉｂｉｏｔｉｃ ｐｅｒｆｕｓｉｏｎ ｇｒｏｕｐ ｗｅｒｅ ８６．８％ ａｎｄ １００．０％， ｒｅｓｐｅｃｔｉｖｅｌｙ （Ｐ＝０．０６７）， ｗｈｉｌｅ ｔｈｅ ｔｉｍｅｓ ｏｆ ｃａｔｈｅｔｅｒｉｚａｔｉｏｎ ｗｅｒｅ ７．８±４．８ ｄａｙｓ ａｎｄ ３．６± ３．１ｄａｙｓ， ｒｅｓｐｅｃｔｉｖｅｌｙ （Ｐ＜０．００１）． Ｃｏｎｃｌｕｓｉｏｎ　Ｔｈｅ ａｎｔｉｂｉｏｔｉｃ ｉｒｒｉｇａｔｉｏｎ ｗｉｔｈ ｔｕｂｅ ｄｒａｉｎａｇｅ， ｅｓｐｅｃｉａｌｌｙ ｔｈｅ ｈｉｇｈ ｃｏｎｃｅｎｔｒａｔｉｏｎ ｐｅｒｆｕｓｉｏｎ ｉｓ ｍｏｒｅ ｅｆｆｅｃｔｉｖｅ ｔｈａｎ ｓａｌｉｎｅ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｂｄｏｍｉｎａｌ ａｎｄ ｐｅｌｖｉｃ ｉｎｆｅｃｔｉｏｎ ｅｆｆｕｓｉｏｎ． [ABSTRACT FROM AUTHOR]

Objective To clear and definite the adverse reactions and clinical manifestations of gadolinium based contrast a gents(GBCAs), to investigate its possible risk f actors and control measures to provide reference for rational and safe use of GBCAs in clinic. Methods The Chinese literatures of adverse reactions caused by using GBCAs during 2008-2018 were retrieved from the databases of Universal Data Knowledge Service Platform, Weipu Information Chinese Journal Service Platform, CNKI. The clinical research literatures and case reports were included. The republication, experimental studies and reviews were excluded. The included literatures conducted the classification statistics and descriptive analysis according to the sex, age, adverse reactions occurrence time, clinical manifestations, possible risk factors inducing adverse reactions, prevention and control measures of adverse reactions. Results Totally 42 articles were included with about 214 342 cases of using GBCAs, the incidence rate of adverse reactions was 0. 19% (397 / 214 342), and the occurrence rate was the highest in people over 40 years old, the majority of its onset times was within 1 h after medication, which were mainly mild and moderate, and the adverse reactions reports of using gadopentetate dimeglumine were predominant. Meanwhile, the past disease history, allergic history, intravenous high pressure injection mode all might be the risk factors inducing the adverse reactions. Conclusion Although the incidence of adverse reactions of GBCAs is relatively low, we should also be vigilant about the possible risk factors besides doing the various coping measures well in clinic. [ABSTRACT FROM AUTHOR]

Objective To explore whether changes of microalbuminuria are paralleled with the reduced glomerular filtration rate in type 2 diabetic patients. Methods A study was conducted in 1 184 type 2 diabetic patients from 27 Beijing community clinics between Apr. 2013 and Mar. 2015. Data of albumin/creatinine ratio (ACR), serum creatinine and lipid profiles were collected. Estimated glomerular filtration rate (eGFR) was evaluated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault(CG), simplified Modification of Diet in Renal Disease (MDRD) formulas, and designated as eGFREPI, eGFRCG, eGFRMDRD, respectively. All data were expressed as x ± s or median (interquartile range) as appropriate. The Student's t test or Mann-Whitney test was used for between-group comparison for continuous variables, and the Chi-square test for categorical variables. Spearman Rank Correlation was used to find the correlation between ACR and eGFR. Results Of all type 2 diabetic patients aged (61±9) yrs, 754 were males (41.6%) and 1 060 were females (58.4%). ACR was not correlated with eGFREPI (r=-0.013), eGFRCG (r=-0.014) or eGFRMDRD (r=-0.007). The changes of microalbuminuria were not paralleled with the reduced glomerular filtration rate. Of patients with macroalbuminuria (defined as ACR≥300 mg/g), 83.3% (15/18) male patients and 50% (11/22) female patients had eGFREPI≥90 ml⋅min-1• (1.73 m²) -1. Of patients with normal albuminuria (defined as ACR<22.1 mg / g in male and ACR<30.9 mg / g in female), 21% (101/482) male patients and 30.7% (238/776) female patients had eGFREPI<90 ml⋅min-1⋅ (1.73 m²) -1, and 2.5% (12/482) male patients and 3.4% (26/776) female patients had eGFREPI<60 ml⋅min-1• (1.73 m²) -1. Conclusion Microalbuminuria can not fully reflect the reduced glomerular filtration rate in type 2 diabetic patients. [ABSTRACT FROM AUTHOR]

Objective To strengthen the maintenance and management of PICC in the treatment of intermittent tumor patients during COVID-19 epidemic,do a good job of home-based guidance for patients,reduce the infection of patients and nursing staff,and ensure the safety during COVID-19 epidemic.Methods Providing online management and home-based guidance for patients with intermittent cancer who need catheter maintenance during COVID-19 epidemic,through the information platform.According to the epidemic situation,making an appointment to connect and maintain the network hospital and time,establishing a management team,strengthening the protection of PICC specialist nurses and enhancing the control of infection in the consulting room,adjusting the maintenance process of PICC,and implementing psychological counseling,etc.Results There were 892 patients, among which 701 patients were maintained in our hospital,101 patients were connected with maintenance networks,63 patients were under technical guidance of networks,165 key points of prevention and control were pushed.There were 86 cases of fever in our hospital,among which 32 cases catched a cold,30 cases belonged to tumor fever,12 cases belonged to catheter-related infection, 10 cases belonged to lung infection and 2 cases belonded to urinary tract infection.Sixteen cases were removed after CT or nucleic acid screening,and the rest of patients were excluded by chest X-ray.The novel coronavirus was not infected by the specialist nurses without any confirmed or suspected COVID-19 cases.Conclusion Facing the outbreak of this epidemic,according to the characteristics of their own disciplines,we should develop the corresponding emergency management program to improve the emergency ability of nurses andto ensure the treatment of intermittent patients with PICC tumor at home safety. [ABSTRACT FROM AUTHOR]

In this paper, the experiment area is dry and prone to soil erosion, in order to stop slope runoff and promote rapid vegetation restoration, a restoration program was implemented. So it is significant for grassland ecological construction to study on the effects of ecological restoration measures on soil properties and soil quality. A study had been done to investigate the different of 0-40 cm soil depth of soil properties and assessment of soil quality under different restoration measures in typical steppe grassland in Ningxia. We selected the sites that has been subject to enclosure(FY), contour trench(SP), fish-scale pits(YL), which were implement in 2001 and grazed(FM) (as a reference, traditional grazing with some supplement) grassland. The results showed that: 1) Soil bulk density of grazing grassland was the highest (P <0.05) whereas the soil clay content, field water holding capacity and total porosity were the lowest (P<0.05), and there was no significant difference (P > 0.05) in soil physical properties between enclosure, contour trench, and fish-scale pits grassland. 2) Soil organic matter and total nitrogen were the highest (P < 0.05) in enclosure grassland, followed by grazed grassland, and the lowest in contour trench. The content of total phosphorus was higher (P = 0.05) in grazed and enclosure grassland, but was the lowest (P < 0.05) in contour trench grassland. The available K content was the highest in grazed grassland the lowest in fish-scale pits grassland (P<0.05). The content of available N was highest in enclosure grassland but lowest in contour trench grassland which were 161.75 mg/kg and 77.17 mg/kg respectively (P<0.05). 3) Soil sucrase and urease activity showed FY>SP>YL>FM; protease and phosphatase activity both showed the highest (P <0.05) in enclosure grassland and the lowest (P <0.05) in the fish-scale pits grassland; the bacteria, actinomycetes and fungi were varied in each treatment; the amount of microorganisms showed FY>FM≈SP>YL whereas microbial biomass carbon and nitrogen showed FY>YL≈SP>FM (P<0.05). 4). As a whole, soil bulk density was negatively correlated with other indexes, and negatively correlated with clay content, field water holding capacity, total porosity, sucrase activity, urease activity, microbial biomass carbon and microbial biomass nitrogen (P<0.01). There was a significant positive correlation between soil organic matter, total nitrogen and available nitrogen (P<0.01) and the correlation between soil enzyme activity and soil microbial population (P<0.05). Soil capillary porosity (except soil microbial biomass nitrogen) and available potassium were not correlated with other indexes (P>0.05). 5) The comprehensive score of soil quality evaluated by the membership function factor analysis method was: enclosure> grazed> contour trench>fish-scale pits grassland. In summary, the enclosure grassland was more conducive to the restoration of typical grassland. Based on the study of the effects of enclosure, contour trench and fish-scale pits on the soil physical and chemical properties and biological traits, the membership quality of soil under different restoration measures was evaluated by membership function and factor analysis and can provide the basis for the ecological construction of typical grassland in Ningxia. The results showed that the enclosure was the most beneficial to the restoration of soil quality in degraded grassland in the study area. [ABSTRACT FROM AUTHOR]

Based on the engineering practice in the building of the artificial seawater canal in Longmu Bay of Hainan Province and aiming at adapting the characteristics of high requirements on canal function, complexity of flat form, low seawater quality and difficulties in ecological and environmental protection, a research was carried out on the key design technology for the general layout, design of water exchange, seawater intrusion protection, water intaking technology, seawater cleaning technology and sluice gate selection. The design proposals such as water exchange cycle and relevant quantity of water intake and displacement, the bank protection structure combining seepage proofing and drainage and ultra-large seawater purifying pool proposal were presented. These proposals have achieved the goals of keeping natural landscape graceful and harmonious in the holiday resort. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of exogenous Sodium hydrogen sulfide (NaHS) on the lesions of lings in rate with hemorrhagic traumatic shock. Methods: All the SD rats were randomly divided into Sham group, HTS group, and NaHS group (n=24 each group). Traumatic hemorrhagic shock model of the rats was established.The rats in Sham group were performed all the operation with out bleeding and the resuscitation; and the rats in HTS group were kept bleeding after completing all the operation and then they were given Ringer'S liquid resuscitation; and the rats in NaHS group were performed all the operation and treated with injection of 28 μmol/kg NaHS (saline were diluted to 0.5 percent) i.p. before the resuscitation. The mean arterial pressure (MAP) and heart rate (HR) of rats were continuously monitored, and the situation of pulmonary edema was evaluated by monitoring the lung coefficient lung wet/dry weight ratio, and the level of SDF-1 and CXCR4 protein was detected by Westem Blot and the change of TNF-α, IL-1β, IL-6 and IL-10 concentration in lung tissue were measured by ELBA. Results: ①Compared with Sham group, after a recovery, the pulmonary coefficient, wet/dry weight ratio were increased significantly in HTS group, and the expression of SDF-1 and CXCR4 were increased, and the concentration of TNF-α, IL-1β, IL-6 in lung tissues was significantly increased (P<0.05); and the difference of 1L-10 concentration was not statistically significant (P>0.05);②compared with the HTS group, after 1 hour's resuscitation, the pulmonary coefficient and wet/dry weight ratio in NaHS group was decreased, and the expression of SDF-1 and CXCR4 were increased, and the concentration of TNF-α, IL-1β, IL-6 in lung tissue were significantly decreased (P<0.05), but the difference of IL-10 concentration was not statistically significant (P>0.05). Conclusions: Exogenous hydrogen sulfide can improve the lung injury after resuscitation in rats induced by traumatic hemorrhagic shock, its mechanism may be through intervention of the SDF-1/CXCR4 pathways and inhibition of the in flammatory reaction after resuscitation. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of moderate static magnetic fields (SMF) on secretion of inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in human monocytic leukemic cell line THP- 1. Methods THP- 1 cells at logarithmic phase were divided into control group and magnetic treatment group. CCK-8 method was used to detect cell proliferation after THP-1 cells were exposed to 60 mT, 200 mT and 400 mT static magnetic fields at 18, 24 and 48 h. Then THP-1 cells were divided into control group, magnetic treatment group, LPS activation group and LPS+SMF treatment group. When magnetic treatment group and LPS+SMF treatment group were exposed to SMF at 18, 24 and 48 h, the levels of the cytokines TNF-α, IL-6 and IL-8 were determined by ELISA. Results (1) 60 mT, 200 mT and 400 mT SMF had no significant effects on cell proliferation in THP-1 cells (P > 0.05). (2)THP-1 cells secreted more TNF-α and IL-6 in 24 h than 18 h in every group, while IL-8 didn′t change. Compared with 24 h, the secretion of TNF-α decreased and IL-6 didn′t change, while IL-8 increased in 48 h. At three sampled time THP-1 cells of LPS activation group secreted more TNF-α, IL-6, IL-8 than those of control group and magnetic treatment group. After magnetic treatment THP-1 cells of LPS+SMF treatment group secreted less TNF-α, IL-6, IL-8 than those of LPS activation group (P < 0.05). Conclusion Static magnetic field may have some inhibitory effects on release of TNF-α, IL-6, IL-8 from THP1 cells, which can provide basic data for the treatment of rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

目的　观察动脉导管未闭（ＰＤＡ）早产儿的血流动力学变化、脑室周围－ 脑室内出血（ＰＩＶＨ）发生情况， 并分析早产儿发生ＰＤＡ 的影响因素。方法　选择２０１５ 年２ 月～ ２０１７ 年２ 月承德医学院附属医院收治的早产儿 １２０ 例，根据是否存在 ＰＤＡ 分为 ＰＤＡ 组（８２ 例）与非 ＰＤＡ 组（３８ 例），观察两组大脑前、中动脉的收缩期峰流速 （Ｖｓ）、舒张末期流速（Ｖｄ）、平均流速（Ｖｍ）、阻力指数（ＲＩ）、搏动指数（ＰＩ）以及 ＰＩＶＨ 发生情况。采用单因素分析法比较两组临床资料，多因素Ｌｏｇｉｓｔｉｃ 回归分析法分析早产儿发生 ＰＤＡ 的影响因素。结果　与非 ＰＤＡ 组比较， ＰＤＡ 组大脑前动脉 Ｖｄ、Ｖｍ 降低及 ＲＩ、ＰＩ 增加，大脑中动脉 Ｖｄ 降低及 ＲＩ、ＰＩ 增加（Ｐ 均＜０． ０５）；与非 ＰＤＡ 组比较， ＰＤＡ 组 ＰＩＶＨ 发生率高（Ｐ ＜０． ０５）。与非 ＰＤＡ 组比较，ＰＤＡ 组产前感染、肺表面活性物质使用、有创机械通气例数多（Ｐ 均＜０． ０５）；多因素Ｌｏｇｉｓｔｉｃ 回归分析显示，产前感染、肺表面活性物质使用、有创机械通气均是影响早产儿发生 ＰＤＡ 的独立危险因素（Ｐ 均＜０． ０５）。结论　ＰＤＡ 早产儿脑血流动力学发生明显变化，ＰＩＶＨ 发生率增加；产前感染、肺表面活性物质使用、有创机械通气影响早产儿发生 ＰＤＡ。 [ABSTRACT FROM AUTHOR]