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【目的】研究系统性红斑狼疮（SLE）患者骨髓基质细胞因子表达情况,及其对外周血淋巴细胞增殖反应的影响,探讨SLE的发病机制。【方法】采用ELISA方法观察SLE患者骨髓基质细胞培养液IL-6、MIP-1、IFN-γ、TGF-β等细胞因子的表达,采用四甲基偶氮唑盐比色法（MTT）,观察基质细胞培养上清液对外周血淋巴细胞增殖反应的影响。【结果】SLE患者骨髓基质细胞培养液IL-6、MIP-1、IFN-γ浓度明显增高,TGF-β则降低,3种细胞因子与SLEDAI评分相关;正常人及SLE患者骨髓基质细胞上清液均对刀豆蛋白A诱导的外周血淋巴细胞增殖有明显的抑制作用,而SLE患者的上清液抑制作用明显低于正常人;在分别加入抗MIP-1、抗IFN-γ单抗后,骨髓基质细胞上清液对外周血淋巴细胞增殖的抑制作用明显增强,而加入抗TGF-β单抗后,抑制作用明显减弱。【结论】SLE患者骨髓基质细胞对外周血淋巴细胞增殖的抑制作用较弱,与其部分细胞因子异常表达有关,骨髓基质细胞可能与SLE的发病、发展有一定关系。

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Copyright of Chinese Journal of Computational Mechanics / Jisuan Lixue Xuebao is the property of Chinese Journal of Computational Mechanics Editorial Office, Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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本文介绍GD-1型8Mb/s实用化光端机的结构设计情况。分别对该机的结构特点;散热与机温测试情况;屏蔽、地线系统进行了叙述。

The intestine is not only an important organ for digestion and absorption of nutrients, but also the main barrier for maintaining a stable internal environment. Therefore, intestinal health determines the overall function and productivity level of animals. The intestinal barrier of poultry includes mechanical barrier, chemical barrier, microbial barrier, and immune barrier. The intestinal barrier is the first line of defense against external toxic and harmful substances, and its functional integrity is the foundation of intestinal health. Impaired barrier function can seriously affect the function of the intestine and its related organs, and even lead to systemic dysfunction. The reasonable supply of dietary nutrients is an important factor in ensuring the integrity of intestinal barrier function and regulating intestinal health. The article focuses on exploring the relationship between various intestinal barriers and intestinal health in poultry, as well as the regulation of dietary nutrition on intestinal health, to provide a reference for improving poultry production performance and health level. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Drainage & Irrigation Machinery Engineering / Paiguan Jixie Gongcheng Xuebao is the property of Editorial Department of Drainage & Irrigation Machinery Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the clinical efficacy of sacubitril/valsartan in the treatment of acute ST-segment elevation myocardial infarction (STEMI) complicated with heart failure preserved ejection fraction (HFpEF) . Methods A total of 120 STEMI patients complicated with HFpEF were selected and randomly divided into the treatment and control groups. In the treatment group, patients were treated with sacubitril/valsartan and their counterparts in the control group were treated with valsartan for 6 months. The resting heart rate (HR), laboratory indexe (plasma N-terminal type B natriuretic peptide precursor (NT-proBNP) concentration, serum growth and differentiation factor-15 (GDF-15) concentration and serum cyclophilin A (CypA) concentration), left ventricular diastolic function indexes (left atrial volume index (LAVI), the ratio of early diastolic mitral valve flow velocity and early diastolic mitral valve ring movement velocity (E/e) ), ultrasound cardiogram (UCG) indexes (left ventricular ejection fraction (LVEF), left ventricular posterior wall thickness (LVPW), left ventricular end-systolic internal diameter (LVESD) and left ventricular enddiastolic internal diameter (LVEDD) ), and adverse events occurring during follow-up were recorded between two groups before and 1, 3 and 6 months after treatment with sacubitril/valsartan. Results In two groups, the resting HR was improved at 1, 3 and 6 months after corresponding treatment, and no significant difference was observed in the resting HR at the same time points between two groups (all P > 0.05) . At 1, 3 and 6 months after treatment, NT-proBNP, GDF-15 and CypA levels and LVEF in the treatment group were significantly improved compared to the control group, and the differences were statistically significant (all P < 0.05) . At 3 and 6 months after treatment, the left ventricular diastolic function indexes (LAVI and E/e) and UCG indexes (LVPW, LVESD and LVEDD) were more significantly improved than those in the control group, and the differences were statistically significant (all P < 0.05) . The incidence of adverse events (sleep disorder, palpitation and hypotension) was not significantly different between two groups (χ2 = 2.679，P = 0.749) . Conclusions Application of sacubitril/valsartanis an efficacious and safe treatment for STEMI patients complicated with HFpEF, which can effectively improve left ventricular diastolic function, enhance left ventricular remodeling and inhibit inflammatory response. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the clinicopathological significance of PDC in liver metastases and analyze the correlation of PDC between liver metastases and primary lesions. Methods Retrospective analysis of 72 matched cases of colorectal cancer with liver metastases was performed. The PDC in primary tumor and liver metastatic lesion was interpreted synchronously, and then the relationship between PDC in liver metastasis and clinicopathological parameters was analyzed based on the correlation of PDC between primary and metastatic lesions. In addition, PDC were interpreted in accordance with Uenos’ standard. Results Among the 72 cases of liver metastasis of colorectal cancer, the number of G1, G2, and G3 graded by PDC was 28, 24, and 20, respectively. The PDC in liver metastatic lesion was correlated with tumor budding in liver metastatic lesion and PDC grade of primary lesion. No significant correlation with the size and number of liver metastatic lesion, the site, WHO grade, depth of invasion, lymph node metastasis, vascular invasion or tumor budding of the primary lesion was observed. Conclusion A positive correlation is found between liver metastasis of colorectal adenocarcinoma and PDC grade of primary tumor. Evaluating the PDC grade of primary tumor may provide a reference for the risk of liver metastasis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Aiming at the limitation of single sensor data in simultaneous localization and mapping in indoor environment, this paper proposed a sensor data fusion method using fuzzy nearness and ad aptive weighting. Firstly, it established the observation model, and firstly merged the data acquired by the Kinect depth camera and the LiDAR data by the method of fuzzy nearness. Then it used the weighting coefficient for the second weighting correction by the method of adaptive weighting. Finally, it com-pared the map built by this method with the map built by a single sensor. The experimental results show that the data obtained by this method is more reliable, and the obtained maps have higher accuracy and smoother environmental features, which verifies the effectiveness of the proposed algorithm. [ABSTRACT FROM AUTHOR]

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