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BACKGROUND: As a skin substitute, acellular dermal matrix has broad prospects and market. OBJECTIVE: To review the clinical application of acellular dermal matrix. METHODS: The authors searched PubMed, CNKI and Wanfang databases for articles published from 2000 to 2021 with the key words of “acellular dermal matrix, reconstruction/repair/plastic/clinical study” in English and Chinese, separately. Finally, 64 articles were included for review. RESULTS AND CONCLUSION: Acellular dermal matrix, characterized by rapid vascularization, low antigenicity, good histocompatibility and stable physicochemical properties, is a commonly used biological material in operations in the head and neck surgery, breast surgery, burn plastic surgery, gynecology, and urology. The main problem lies in its low output and the complicated production process to meet the medical standards. Thus, the price of acellular dermal matrix used in clinical use is high, increasing the medical economic burden of patients. Although most of the alloantigen substances are removed, acellular dermal matrix is still a foreign material for patients, so there is still a risk of surgical complications, such as rejection and infection. For future acellular dermal matrix, it is necessary to optimize the production process, improve the production process, reduce the production cost and increase the commercial specifications. From improving the decellularization process, it further removes proteins and other allergens from the acellular dermal matrix while preserving the dermal matrix, further reduces the immunogenicity of the acellular dermal matrix, enhances its compatibility, and reduces adverse events, such as infection and rejection. [ABSTRACT FROM AUTHOR]

Objective To investigate the CYP4A11 gene rs9333025 A/G Polymorphism in a Yi nationality population in Yunnan Province，and to build a foundation for the future research of CYP4A11 related diseases. Methods We studied 303 healthy subjects of Yi nationality in rural area of Jinning，Yunnan Province. The CYP4A11 rs9333025 A/G Polymorphism was determined by Polymerase chain reaction- restriction fragment （PCRRFLP） technique. The genotype frequencies and allele frequencies were obtained and compared with those collected from other population. Results In this healthy Yi group of Yunnan province，frequencies for the AA、AG and GG genotypes were 2.31%、27.72% and 69.97%; derived allele frequencies for the A and G allele were 16.17% and 83.83% . The distribution of CYP4A11 genotypes and the allele frequencies in this Yi group were significantly different from Japanese（P＜0.05）；compared with the Han nationality, the difference in genotype distribution was not statistically significant（P > 0.05），but the difference in allele frequency was statistically significant （P < 0.05）；compared with Mongolian, there was no significant difference in genotype and allele frequency. Conclusion The frequency of the genotype or the allele of CYP4A11 rs9333025 A/G polymorphism is different significantly in different national populations. [ABSTRACT FROM AUTHOR]