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文章仿真研究了两种改进型光双二进制调制格式。首先对比分析了产生两种改进型光双二进制调制格式的发射机结构及两种调制格式的码型和频谱特性,随后进行了系统的传输性能仿真。仿真结果表明:当残留色散较大时,改进Ⅱ型光双二进制调制格式性能较为优异;而在-13.22.8dBm入纤光功率范围内,与改进Ⅱ型光双二进制和NRZ（非归零）码调制格式相比,改进Ⅰ型光双二进制的Q值最高,抗非线性效应能力最强。

Objective To evaluate the application of Plan-Do-Check-Action cycle(PDCA) model in management of breast cancer patients undergoing peripherally inserted central catheter (PICC)placement. Methods According to sequence of hospital admissions, totally 100 breast cancer patients undergoing PICC placement were divided into the control group and observation group, with 50 patients in each group. Routine PICC maintenance was carried out in the control group during the treatment, and PDCA cycle model was used in management of PICC placement in the observation group. The incidence of complications, treatment compliance and patient satisfaction were compared between two groups. Results The incidence rates of puncture-site infection, catheter blockage and fever induced by catheter-related infection in the observation group than those in the control group, and a significant difference was found in catheter blockage rate between two groups (P＜0. 05). Patients in the observation group had a better outcome of treatment compliance and satisfaction assessment than those in the control group (P＜0. 05). Conclusion The PDCA cycle mode in an effective tool in quality improvement of PICC maintenance for breast cancer patients. It is able to reduce the incidence of complications and improve the treatment compliance and satisfaction of patients. (目的 探讨PDCA循环质量管理模式在乳腺癌患者经外周静脉置入中心静脉导管(PICC)置管管理中的应用效果。方法 选取2019年3月—2021年3月医院收治的100例乳腺癌PICC置管患者为研究对象, 根据入组的先后顺序分为观察组和对照组, 各50例。治疗期间, 对照组接受常规护理和PICC置管维护; 观察组实施基于PDCA循环模式的PICC置管维护和管理。比较两组患者的并发症发生情况、治疗依从性以及满意度。结果 观察组穿刺口感染、导管堵塞和发热反应发生率均低于对照组, 其中导管堵塞发生率两组比较, 差异有统计学意义(P＜0. 05)。观察组患者治疗依从性和满意度评价均优于对照组, 差异有统计学意义(P＜0. 05)。结论 PDCA循环模式能提升乳腺癌患者PICC置管维护和管理质量, 降低并发症发生风险, 提升患者治疗依从性和满意度。)

This paper analyzed the potential factors causing constipation in elderly patients with stroke, and reviewed the studies on effect of Traditional Chinese Medicine (TCM) nursing in relief of constipation after stroke. Suggestions were provided for the further study and clinical practice of TCM nursing intervention on constipation in elderly stroke patients. (本文整理和分析引起老年脑卒中便秘的因素及采用中医护理措施改善老年脑卒中便秘的研究现状, 旨在为进一步深入研究中医护理对老年脑卒中便秘的应用提供参考和依据。)

Objective To investigate the effect of predictive nursing strategies on preventing side effects of azacitidine in patients with high-risk myelodysplastic syndrome. Methods Totally 40 patients undergoing subcutaneous injection therapy with azacitidine for high-risk myelodysplastic syndrome were randomly divided into the observation group and control group, with 20 cases in each group. Routing nursing management including posture nursing, oral care, psychological care and nursing of adverse reactions was carried out in the control group. In the observation group, a special nursing team was set up to enhance the predictive nursing interventions such as nutrition support, prevention of infection and hemorrhage, and so on. The side effects of azacitidine therapy were observed analyzed. Results The incidence of adverse reactions in the observation group was significantly lower than that in the control group (10. 00% vs. 45. 00%, P＜0. 05). Conclusion For those patients undergoing subcutaneous injection therapy with azacitidine for high-risk myelodysplastic syndrome, the predictive nursing is potentially effective to reduce the incidence of adverse drug reactions. (目的 探讨预见性护理干预预防较高危骨髓增生异常综合征患者阿扎胞苷治疗所致不良反应的效果。方法 40例较高危骨髓增生异常综合征患者随机分为观察组(n=20)和对照组(n=20)。两组患者均给予阿扎胞苷皮下注射治疗。对照组实施常规护理, 包括体位护理、口腔护理、心理护理和不良反应护理; 观察组实施预见性护理干预, 成立预见性护理小组, 强化营养干预、感染预防、出血预防等护理措施。比较两组不良反应发生情况。结果 观察组不良反应发生率10. 00%(2/20), 低于对照组的45. 00%(9/20), 差异有统计学意义(P＜0. 05)。结论 对较高危骨髓增生异常综合征患者, 应用阿扎胞苷治疗的同时配合预见性护理, 可以有效降低不良反应的发生风险。)

Sepsis shock is a life-threatening disease to ICU patients, which is one of the important factors causing the death of ICU patients. This paper summarized the nursing measures for a patient with septic shock, including nursing personnel arrangement, illness condition observation, medication care, skin care, mechanical ventilation nursing, and nutrition support. In addition to giving patients scientific and effective treatment, it is of positive significance to carry out detailed and comprehensive nursing measures for patients with septic shock. (脓毒症休克是 ICU 患者可能发生的一种严重性疾病, 是致使患者出现死亡的重要因素之一。本文总结了1例脓毒症休克患者的护理经验, 包括护理人员配置、病情观察、用药护理、皮肤管理、机械通气护理、营养支持等措施。临床中针对脓毒症休克的干预, 除了要给予科学有效的治疗措施外, 为患者展开细致化、全面化的临床护理措施, 并根据患者具体情况落实有针对性的护理具有积极意义。)

This article summarized the current situation of early treatment and rehabilitation nursing services for urinary incontinence after stroke in China. The main contents of the article included medication treatment and care, rehabilitation training, surgical treatment, Traditional Chinese Medicine intervention, skin care, psychological intervention, health behavior guidance. It is required to provide a comprehensive, targeted and early preventive medical care for patients with post-stroke urinary incontinence, which can effectively improve the success rate of early treatment and the quality of medical care services, but also enhance the quality of life of patients. (本文总结了国内脑卒中后尿失禁的早期治疗与康复护理服务现状, 主要内容包括药物疗法、康复训练、手术治疗、中医干预、皮肤护理、心理干预、生活指导等。脑卒中后尿失禁患者早期给予全面性、针对性以及预防性的治疗和护理, 能有效缓解患者症状, 在提高医疗护理服务质量的同时, 改善患者日常生活质量。)

Objective To investigate the effect of Traditional Chinese medicine (TCM) collapse stains on relief of shoulder pain after stroke. Methods A total of 60 patients with post-stroke shoulder pain were randomly divided into study group (n=30)and control group (n=30). The control group was given routine nursing, comprehensive rehabilitation training and nursing by TCM syndrome differentiation. The study group was given TCM collapse stains method for 2 weeks on the basis of the control group. The Self-rating Anxiety Scale (SAS), Visual Analogue Scale (VAS) and modified Barthel Index(mBI) were used to evaluate the patients ‘anxiety states, degree of shoulder pain and activity of daily living respectively. The intervention effect of two groups was compared. Results Scores of SAS and VAS in the study group were lower than those in the control group after treatment (P＜0. 01, respectively). The score of MBI in the study group was higher than that in the control group after treatment (P＜0. 05). The total effective rate was 96. 67%(29/30) in the study group, which was significant higher than 76. 67%(23/30) in the control group (P＜0. 05). Conclusion The collapse stains, as an external TCM therapy, is potentially effective to relieve the shoulder pain after stroke and improve the recovery of activity of daily living in patients with post-stroke shoulder pain. (目的 探讨中药塌渍治疗脑卒中后肩痛的效果。方法 选取2021年1月—12月符合纳入标准的60例卒中后肩痛患者, 采用随机数字表法将患者随机分为研究组对照组, 各30例。对照组给予常规护理、综合康复训练和中医辨证施护, 研究组在对照组基础上增加中药塌渍疗法, 疗程为2周。采用焦虑自评量表(SAS)、疼痛视觉模拟量评分(VAS)量表、Barthel指数 (BI)分别评价患者焦虑程度、疼痛程度和日程生活活动能力, 评价并对比两组干预效果。结果 治疗后, 研究组SAS评分和VAS评分低于对照组, 差异有统计学意义(P＜0. 01)。治疗后, 研究组MBI评分高于对照组, 差异有统计学意义(P＜0. 05)。研究组总有效率96. 67%(29/30), 高于对照组的76. 67%(23/30), 差异有统计学意义(P＜0. 05)。结论 中药塌渍外治方法能够减轻脑卒中后肩痛患者肩部疼痛程度, 缓解焦虑情绪, 促进康复。)

Traditional Chinese Medicine (TCM) emotional nursing is a kind of psychological therapy, which is based on the theory of medical psychology, through the language, expression, posture, attitude, behavior and temperament of the nursing staff to affect and improve the patient emotional state. According to the patient’s condition, appropriate psychological care is carried out to relieve the negative emotions, so as to achieve the purpose of disease prevention and treatment. (中医情志护理是一种社会心理疗法, 是根据中国医学教育心理学的理论, 通过提高护士的语言、表情、姿势、态度、行为及气质等来影响和改善患者的情绪。护士需要根据手术患者的病情情况, 给予适当的心理护理, 改善不良状态, 从而达到疾病防治的目的。)

Objective To observe the bonding strength, bonding failure mode, surface and bonding interface characteristics of 3D printed porous titanium alloy posts, in order to improve the bonding strength of metal posts by utilizing mechanical interlocking of porous structures. Methods Four experimental groups were designed. In the group A, we selected 10 preformed fiber posts, scanned and obtained three-dimensional data. In the groups B, C, and D, we used the data obtained from group A to design and manufacture 3D printed solid titanium alloy posts, 3D printed porous titanium alloy posts, and zirconia posts. The posts were embedded and sliced, and the posts were pushed out of the resin using a universal mechanical testing machine. The bonding strength and bonding failure mode of posts in each group were recorded, and the surface and bonding interface characteristics of the posts were observed using a scanning electron microscope. Results The adhesive strengths of groups A, B, C, and D were (229. 11 ± 80. 15), (389. 29 ± 58. 39), (572. 35 ± 1280. 8), and (137. 54 ± 26. 81) MPa, respectively, with statistically significant difference between every two groups (all P<0. 05). The numbers of cases of adhesive interface failure in the groups A, B, C, and D were 7, 2, 1, and 8, respectively； the numbers of cases of internal adhesive failure were 0, 1, 3, and 0, respectively； the numbers of cases of mixed adhesive failure were 3, 7, 6, and 2, respectively； there were statistically significant differences between every two groups (all P<0. 05). Under the scanning electron microscope, in the group A, a large number of tightly arranged fiber bundles were seen on the surface of the fiber post, and the fiber post was tightly bonded to the post core resin； in the group B, there were a large number of spot-shaped particles on the surface of the 3D printed solid titanium alloy posts, with resin embedded between the spot-shaped particles, and the titanium alloy solid post was tightly bonded to the post-core resin； in the group C, there were a large number of irregular voids on the surface of 3D printed porous titanium alloy posts, and there were also a large number of spot-shaped particles on the surface of the posts. A large amount of resin embedded was seen between the particles and the voids, greatly increasing the mechanical interlocking effect between the posts and the core resin； in the group D, the zirconia posts and surface were relatively flat, and the posts and core resin were tightly bonded, with significantly less mechanical interlocking than that of the previous three groups. Conclusions Compared with the preformed fiber posts, zirconia posts, and 3D printed solid titanium alloy posts, porous titanium alloy posts made using 3D printing technology have significantly improved bonding strength. The bonding failure mode is mainly the mixed bonding failure, with a large number of irregular voids and spot-shaped particles on the post surface. A large amount of resin embedded can be seen between the particles and voids, greatly increasing the mechanical interlocking effect between the posts and the resin. [ABSTRACT FROM AUTHOR]

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Moral education is the mission of higher education in the new era, and experimental teaching is an important part of this mission. Under the background of the “101 plan”, this article introduces the experiences of the construction and development of Zhejiang University National Chemical Experimental Teaching Demonstration Center from the aspects of experimental teaching system, experimental teaching content, experimental teaching team, experimental teaching informatization construction, and the construction of both software and hardware. Relying on the center’s construction, we adhere to the new education concept that integrates personality, quality, ability and knowledge (KAQ2.0). This approach continuously improves our ability to independently cultivate top-notch innovative talents in basic disciplines. [ABSTRACT FROM AUTHOR]

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Objective To investigate the effect of holographic meridian scraping therapy combined with auricular bloodletting therapy in the treatment of elderly patients with primary hypertension. Methods Totally 60 elderly patients with primary hypertension were randomly divided into the observation group and the control group, with 30 cases in each group. On the basis of drug therapy and routine health education, the control group received auricular bloodletting therapy, while the observation group received holographic meridian scraping therapy combined with auricular bloodletting therapy. The changes in blood pressure and Traditional Chinese Medicine (TCM) syndrome score were observed, and the intervention effect was evaluated by comparing the improvement of blood pressure and clinical symptoms. Results The systolic pressure and diastolic pressure in the observation group dropped more significantly compared with those in the control group after intervention (P＜0. 05). There was a lower TCM syndrome score in the observation group than that in the control group after intervention (P＜0. 05). There was no significant difference in total effective rate between two groups (P＞0. 05). Conclusion The holographic meridian scraping therapy combined with auricular bloodletting therapy is potentially effective to reduce the blood pressure and relief the TCM syndrome in patients with primary hypertension. (目的 观察全息经络刮痧联合耳尖放血疗法治疗老年高血压病的临床疗效。方法 60例老年高血压病患者根据随机数字表法分为对照组和观察组, 各30例。除常规药物治疗和健康指导外, 对照组实施单纯耳尖放血疗法, 观察组给予全息经络刮痧联合耳尖放血疗法干预。比较2组患者血压和中医证候评分, 评价干预效果。结果 干预后, 观察组收缩压和舒张压下降幅度大于对照组, 差异有统计学意义(P＜0. 05); 观察组中医证候积分下降幅度大于对照组, 差异有统计学意义(P＜0. 05); 观察组总有效率高于对照组, 但差异无统计学意义(P＞0. 05)。结论 全息经络刮痧联合耳尖放血疗法能有效降低老年高血压病患者的血压, 改善中医证候。)

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Objective To investigate the potential mechanism of osteoking in the treatment of type 2 diabetic osteoporosis by inhibiting osteoblast ferroptosis from the perspective of network pharmacology and molecular docking.Methods TCMSP database and BATMAN-TCM database were used to retrieve the components and targets of traditional Chinese medicine, and GeneCards and OMIM database were used to obtain the disease targets of osteoporosis in type 2 diabetes.The PPI protein interaction network was constructed with STRING11.0 database, and topological analysis was performed to screen important targets in the network. The potential therapeutic targets were imported into the DAVID online database for gene ontology(GO) enrichment analysis and gene and genome encyclopedia(KEGG) pathway enrichment analysis.Finally, molecular docking simulation was performed to verify the results of network pharmacology.Results A total of 223 potential therapeutic targets were obtained through network pharmacology screening.The key active substances of osteoking in the treatment of type 2 diabetic osteoporosis are luteolin, 20(R)-ginsenoside Rh2, kaempferol, baicalein, beta-sitosterol, etc.The key targets are IL-6, Akt, TNF, MAPK3, HIF-1A, etc.The results of GO and KEGG analysis showed that the treatment of osteoporosis in type 2 diabetes by osteoking mainly included biological processes such as lipopolysaccharide response, hypoxia response, and inflammatory response, and regulated HIF-1A, TNF, IL-17, PI3K/Akt and other signaling pathways.The results of molecular docking showed that 7-O-methylisoprostol, baicalein, kaempferol, and quercetin had good binding activity with HIF-1A.Conclusion Through network pharmacology and molecular docking technology, it is found that osteoking may treat type 2 diabetic osteoporosis through multiple targets, and may reduce oxidative stress and inhibit osteoblast ferroptosis through HIF-1A signaling pathway to treat type 2 diabetic osteoporosis. [ABSTRACT FROM AUTHOR]