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OBJECTIVE: Chronic ankle instability is mainly characterized by symptoms such as muscle weakness, intermittent pain, and repeated sprains, which seriously affect exercise and daily life. Loss of proprioception, prolongation of fibular reaction time, and weakening of valgus force may be the main symptoms of chronic ankle instability, so exercise intervention can effectively improve the symptoms related to ankle instability. Meta-analysis was used to quantitatively evaluate the effect of balance training on the rehabilitation intervention of chronic ankle instability, providing a reliable theoretical basis and practical basis for chronic ankle instability patients to scientifically formulate exercise prescriptions. METHODS: The randomized controlled trial of balance training on symptom rehabilitation and dynamic equilibrium of patients with chronic ankle instability was retrieved on CNKI, VIP, Web of Science, and PubMed. The literature was published from the inception to November 23, 2022. Two reviewers were included to evaluate the quality of the included literature based on the physical therapy evidence scale. The primary outcome measure is the Self Functional Rating Scale, and the secondary outcome measure is the Star Shift Balance Test, both of which are continuous variables. Forest mapping, meta-regression, subgroup analysis, sensitivity analysis, and publication bias evaluation were performed on the included literature using RevMan 5.3 and Stata-SE 15 software. RESULTS: (1) A total of 18 articles of randomized controlled trials were screened and 641 patients with chronic ankle instability were included in the study. Overall, the methodological quality of the literature was relatively high. (2) Meta-analysis results showed that balance training improved the functional rehabilitation effect of chronic ankle instability patients (SMD=0.82, 95% CI:0.41-1.23, P < 0.000 1). Meta-regression exhibited that intervention time might be the main reason for heterogeneity (P=0.008). (3) The subgroup analysis results revealed that 6 weeks of intervention (SMD=0.98, 95% CI:0.31-1.65, P=0.03), more than 3 interventions per week (SMD=0.87, 95% CI:0.30-1.44, P=0.003), and each intervention time less than 20 minutes (SMD=0.89, 95% CI:0.61-1.66, P < 0.000 1) were the best rehabilitation plans to improve the functional rehabilitation effect of chronic ankle instability patients. (4) Meta-analysis results also showed that balance training improved the stretching degree of the anterior side (SMD=0.56, 95% CI:0.31-0.80, P < 0.05), posterior inner side (SMD=0.88, 95% CI:0.45-1.32, P < 0.05), and posterior outer side (SMD=0.84, 95% CI:0.22-1.46, P < 0.05) of the star shift balance test. CONCLUSION: Current clinical evidence shows that balance training can improve ankle instability symptoms and elevate dynamic equilibrium ability in chronic ankle instability patients. It is recommended to intervene more than 3 times a week, with each intervention lasting less than 20 minutes, to achieve better rehabilitation effects. [ABSTRACT FROM AUTHOR]

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Copyright of Modern Educational Technology is the property of Editorial Board of Modern Educational Technology, Tsinghua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In view of the problem that it is difficult to accurately describe the dynamic working principle of the system and reproduce the motion control function of the real system when the virtual reality technology of the complex system is applied, the hydraulic six degrees of freedom (six-DOF) parallel mechanism with high order, nonlinear, strong coupling and other characteristics was used as the research object, and a virtual reality technology using user datagram protocol (UDP) was proposed between the professional software MATLAB and the virtual reality development software Unity3D. Firstly, the three dimensions (3D) model of the parallel mechanism was built in the 3D modeling software SolidWorks, and the model was imported into the Unity3D software and the joint constraints were applied on it. Secondly, the inverse kinematics of the parallel mechanism was solved, and the joint simulation model of the MATLAB software and the AMESim software was established. Finally, through UDP, Two-way real-time data interaction was realized between the MATLAB software and the Unity3D software, and the virtual mechanism was drove to action. The results show that the actions of the virtual mechanism are fully conformed to the working principle of the real physical system, and the virtual reality technology based on the UDP data-driven is good accuracy and real-time performance. [ABSTRACT FROM AUTHOR]

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Copyright of Laboratory Animal & Comparative Medicine is the property of Laboratory Animal & Comparative Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chinese herbal medicine is a kind of green feed additive which can replace antibiotics because of its wide source, convenient sampling, low residue, and no drug resistance. Chinese herbal medicine contains organic acids, alkaloids, flavonoids, volatile oils, and other active ingredients, which have good physiological effects in antioxidant, antibacterial, anti-inflammatory, immune enhancement, anti-tumor and so on. Chinese herbal additives can promote the growth and development of animal body, promote the digestion and absorption of animal body, improve intestinal health, enhance immune and antioxidant properties, prevent and treat diseases, and have a good application prospect in animal production. The article reviews the biological functions of Chinese herbal medicine additives, discusses their application in ruminant production and disease prevention, and provides a reference for the efficient utilization of Chinese herbal medicine additives in healthy ruminant farming without resistance. [ABSTRACT FROM AUTHOR]

Copyright of China Textile Leader is the property of China Textile Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Earthquake Sciences is the property of China Earthquake Administration, Institute of Geophysics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: Epidermal growth factor receptor exon 20 T790M (EGFR T790M) mutation is one of the acquired resistance mechanisms in non-small cell lung cancer (NSCLC) against first-/second-generation EGFR tyrosine kinase inhibitors (EGFR TKIs). Additionally, EGFR T790M mutation can also be observed in NSCLC patients who have not undergone EGFR TKIs treatment. This study aimed to compare the clinical pathological characteristics and prognostic differences between NSCLC patients with de novo and acquired EGFR T790M mutation, and further explore the immune microenvironment features of acquired T790M mutation in NSCLC. Methods: This study retrospectively included 3 762 cases of NSCLC diagnosed at Fudan University Shanghai Cancer Center from April 2020 to September 2022. Among them, 2 070 cases (55.02%) exhibited EGFR mutations, and 556 cases (14.77%) received EGFR TKIs treatment. Specifically, there were 119 cases (3.16%) of NSCLC with EGFR T790M mutation, including 51 cases (1.35%) of de novo T790M mutation and 68 cases (1.81%) of acquired EGFR T790M mutation. Clinical data of the patients were collected for comparative analysis between NSCLC patients with de novo and acquired T790M mutation. Multiple immunofluorescence histochemistry (mIHC) was employed to explore the immune microenvironment characteristics of NSCLC patients with acquired T790M mutation. Results: The proportion of de novo and acquired T790M mutations was higher in female patients compared to males. Patients with de novo T790M mutation tended to be younger. Both de novo and acquired T790M mutations were more commonly found in poorly differentiated carcinomas. Among NSCLC patients with de novo T790M mutation, there was a higher rate of programmed death ligand-1 (PD-L1) expression (60.00%). In contrast, among NSCLC patients with acquired T790M mutation, the rate of PD-L1 expression was lower (22.39%). Acquired T790M mutation in NSCLC was often accompanied by TP53 alterations (39.7%). Cox regression analysis results indicated that mesenchymal to epithelial transition (MET) factor alteration was a risk factor for the occurrence of acquired T790M mutation (P=0.000 5). The average overall survival (OS) showed no significant difference between de novo and acquired T790M mutations (35.4 and 37.3 months respectively). However, patients with acquired T790M mutation exhibited a higher proportion of recurrence and metastasis. In acquired T790M mutation, there was a higher presence of immune cell infiltration within the stromal compartment, such as CD20+B cells, CD23+ B cells, CD8+ T cells, CD8+PD-1-/+ cells, CD20+PD-1-/+ cells and CD23+PD-1-/+ cells. Additionally, the study found that when EGFR was accompanied by tumor suppressor gene (TSG) alterations, the average distance between tumor cells and CD8+ T cells, CD20+ B cells, CD8+PD-1+ cells, CD20+PD-1+ cells and CD23+PD-1+ cells was closer compared to cases with only EGFR mutations. Conclusion: In comparison to patients with de novo T790M mutation, patients with acquired T790M mutation exhibit a lower rate of PD-L1 positivity. Acquired T790M mutation often accompanies TP53 alterations, and MET alteration is identified as a risk factor triggering acquired T790M mutation. Although patients with acquired T790M mutation face higher risk of recurrence and metastasis, their average OS does not significantly differ from those with de novo T790M mutation. In cases of acquired T790M mutation, the presence of TSG mutations can alter the spatial distribution of immune cells, potentially leading to benefits from immunotherapy. [ABSTRACT FROM AUTHOR]

Copyright of South China Fisheries Science is the property of South China Fisheries Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Geology & Exploration is the property of Geology & Exploration Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Dalian Polytechnic University is the property of Journal of Dalian Polytechnic University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China University of Petroleum is the property of China University of Petroleum and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Educational Technology is the property of Editorial Board of Modern Educational Technology, Tsinghua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Poyang Lake is the property of Journal of Poyang Lake Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

One patient with gallbladder mass had transient jaundice and was diagnosed with gallbladder carcinoma by abdominal ultrasonography, contrast-enhanced CT, MRCP, and PET-CT. Surgical exploration showed enlarged gallbladder and a mass in the neck of the gallbladder pressing against the hilum of the liver, with no manifestation of tumor invasion, and there were no signs of liver metastasis. Only cholecystectomy was performed for the patient. The pathological diagnosis was tubular adenoma of the gallbladder without carcinogenesis. This case is characterized by a large gallbladder tumor, without marginal infiltration on imaging or malignant transformation based on pathology. [ABSTRACT FROM AUTHOR]

【目的】探讨纳米炭混悬液在分化型甲状腺癌合并其他甲状腺疾病行颈中央区淋巴清扫中的示踪效果差异。【方法】回顾性分析2015 年7 月至2019 年7 月梅州市人民医院收治的分化型甲状腺癌患者共500 例， 将患者分为纳米炭组（A 组）314 例及非纳米炭组（B 组）186 例，并根据无合并疾病（亚组0）、合并多结节性甲状腺肿（亚组1）、合并桥本氏甲状腺炎（亚组2）或甲状腺癌灶较大（肿瘤最大径超过30 mm，亚组3），进一步将A、B 两组分成 4 个亚组，比较各组的淋巴结检获数及术后并发症的发生情况。【结果】A 组的淋巴结检获数和转移率均多于B 组［6.0（3.0 ~ 9.0）vs. 3.0（1.0 ~ 5.3），P < 0.001；24.4% vs. 20.7%，P = 0.041）］；A0 组、A1 组、A2 组的淋巴结检获数均多于B0［8.0（6.0~11.0）vs. 3.0（2.0 ~ 6.0），P < 0.001）］、B1［4.0（3.0 ~ 6.8）vs. 3.0（0.0 ~ 5.0），P < 0.001）］、 B2［8.0（5.0 ~ 12.0）vs. 4.0（0.0 ~ 6.5），P = 0.002］组。同为术中使用纳米炭，A1、A3 组的淋巴结检获数显著少于 A0 组［4.0（3.0~6.8）vs. 8.0（6.0 ~ 11.0），P < 0.001；3.0（2.0 ~ 6.0）vs. 8.0（6.0 ~ 11.0），P < 0.001）］；A1、A2、A3 组和 A0 组相比，声嘶的发生率均无统计学意义（P > 0.05），A2、A3 组术后甲状旁腺功能减退的发生率显著高于A0 组（51.8% vs. 34.1%，P < 0.05；54.2% vs. 34.1%，P < 0.05）。【结论】分化型甲状腺癌术中应用纳米炭可提高淋巴结的检获数，无合并疾病的作用效果最佳，合并多结节性甲状腺肿、癌灶过大可影响纳米炭的示踪效果，当癌灶最大径大于30 mm 时应用纳米炭对淋巴结的检出无明显作用。

目的 探讨维持性血液透析 (MHD) 患者心脏瓣膜钙化 (CVC) 发生的影响因素。方法 选取行 MHD 患者 176 例, 根据心脏超声检测结果分为 CVC 组 (n=84) 和无 CVC 组 (n=92), 比较两组临床资料及血清甲状腺激素水平 差异, 采用多因素 Logistic 回归分析 MHD 患者 CVC 的危险因素, 根据 MHD 患者发生 CVC 独立危险因素构建预测模 型, 采用受试者工作特性 (ROC) 曲线评估游离三碘甲状腺原氨酸 (FT3) 及预测模型对 CVC 的预测价值。结果 176 例 MHD 患者中 84 例 (47. 73%) 存在 CVC, 其中主动脉瓣钙化 74 例 (42. 04%), 二尖瓣钙化 38 例 (21. 59%), 56 例 (31. 82%) 患者存在单个瓣膜钙化, 28 例 (15. 90%) 同时存在主动脉瓣及二尖瓣钙化。CVC 组年龄、透析龄、甘油三 酯、血清磷、CRP 高于无 CVC 组, 前白蛋白、血清 Klotho 蛋白、FT3 低于无 CVC 组, 差异均有统计学意义 (P 均<0. 05) 。 Spearman 相关性分析显示, 血清 FT3 与瓣膜钙化数量、IL-6 呈负相关 (r 分别为－0. 298、－0. 236, P 均<0. 05), 与血清 Klotho 蛋白呈正相关 (r=0. 366, P<0. 05) 。Logistic 回归分析显示, 年龄、甘油三酯升高、Klotho 蛋白降低及 FT3 降低 是 CVC 发生的独立危险因素 (P 均<0. 05) 。ROC 曲线分析结果显示, 基于独立危险因素构建的预测模型预测 MHD 患者 CVC 的曲线下面积为 0. 823 (95% CI : 0. 761~0. 884, P<0. 05), 大于 FT3 单一指标预测 (AUC=0. 676, 95% CI: 0. 597~0. 755, P<0. 05), 差异有统计学意义 (P<0. 05) 。结论 维持性血液透析患者中血清 FT3 与 CVC 密切相关, 年 龄、甘油三酯升高、Klotho 蛋白降低及 FT3 降低是 CVC 发生的独立危险因素, 基于危险因素建立的预测模型对透析 患者 CVC 发生有较好的预测价值。 [ABSTRACT FROM AUTHOR]

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