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To investigate the trend of functional groups of matrix asphalt, styrene butadiene styrene ( SBS) modifiers, and their modified asphalt with aging time, and to analyze their aging modes. Using Fourier transform infrared spectroscopy (FTIR) and bending beam rheometer (BBR) tests, low-temperature performance tests were conducted on two types of asphalt binders aged for 0, 1, 5, 8, 24, 48, 72 h. Functional group analysis was conducted with SBS modifier to establish the relationship between the functional groups of the two asphalt binders and their low-temperature performance. The results show that SBS modifier aging are contributed by polybutadiene and polystyrene, the SBS modifier aging mode is degraded mainly alkene and alkane in the thermal oxidation process. Two kinds of asphalt binders aging mode are volatilized light oil and reacted with oxygen to form a cross-linked. The trend of SBS modifier at the characteristic peaks in infrared absorption spectra is different and independent of its modified asphalt. Two kinds of asphalt binders carbonyl index is correlative with creep compliance derivative, and low-temperature deformation capacity of asphalt binder is reflected by carbonyl index. [ABSTRACT FROM AUTHOR]

Focusing on the main research progress of thermoplastic elastomer modified asphalt, the thermoplastic elastomer materials being used in road engineering is emphasized・ The influencing mechanism of thermoplastic elastomer on asphalt is analyzed in the aspects of the thermoplastic elastomer material struc・ ture, relative molecular mass and compatibility with asphalt. The advantages of thermoplastic elastomer in asphalt modification are revealed, the problems existing in the current research results are summarized and the development trend of this kind of materials in the future are prospected・ These results provide a theo・ retical basis for subsequent in-depth study and popularization and application. [ABSTRACT FROM AUTHOR]

Unidirectional UD-CFRP, bidirectional 2D-CFRP, and unidirectional and bidirectional combination UD + 2D-CFRP composites were prepared by fiber winding technique to investigate the effect of the orientation of carbon fibers and their functional groups on the thermo・mechanical properties of carbon fiber reinforced polymer (CFRP) composites・ The results show that the mechanical and thermmechanical properties of the CERP composites are related to the direction of carbon fiber arrangement, and the single・ aligned UD-CFRP has better mechanical and thermo-mechanical properties. [ABSTRACT FROM AUTHOR]

Two composite modified asphalts were prepared using different plasticizer: dioctyl phthalate (DOP) and dioctyl adipate(DOA) basing on SBS modified asphalt. Through asphalt basic index, dynamic shear rheometer, multiple stress creep recovery, bending beam rheometer and fourier transform infrared spectroscopy(FTIR) tests, the high and low temperature performance and anti-aging capability of two composite modified asphalts were comprehensively studied before and after aging, and being compared with SBS modified asphalt・ Two high temperature grades of SBS modified asphalt can be reduced by adding plasticizer that resulting in the rutting resistance decrease and irrecoverable deformation increase・ The low-temperature deformation and retarding pavement cracking capacity of SBS modified asphalt is improved by adding plasticizer. The performance difference of SBS modified asphalt with plasticizer before and after aging is obviously reduce・ Physical cross linking reaction being reacted between SBS modified asphalt and plasticizer is reflected by FTIR, the anti-aging capability of SBS modified asphalt is enhanced by adding plasticizer basing on sulfoxide index and characteristic peak area. [ABSTRACT FROM AUTHOR]

Scenario simulation and prediction of future land use is an integral step in ensuring regional sustainable development. The Markov chain was adopted to predict the total area of various types of land use in 2030. As envisaged in the 14th Five-Year Plan for Guangzhou Transportation, the PLUS model was used to simulate the land use pattern of Guangzhou in 2030 by setting up natural development and traffic planning scenarios. Additionally, the land use transfer matrix and landscape index were applied to explore the properties of land use type transformation and landscape pattern under two different scenarios. The results show that traffic planning has a significant impact on the artificial surface, within 3 km of traffic line，with the area of the artificial surface under the traffic planning scenario increasing by 22.06 km2 compared with the natural development scenario, which mainly transferred from cultivated land and forest land. The artificial surface will mainly undergo extensive expansion under these two scenarios. In the natural development scenario, the spreading speed of the artificial surface in each region will be relatively consistent, while in the traffic planning scenario, the artificial surface will be concentrated in the periphery of the central urban area, and the probability of distribution far away from the city center is low. Compared with natural development scenario, traffic planning scenario has higher patch dominance and more complicated patch form, which is reflected in the artificial surface with significantly increased dominance and cultivated land and grassland with more fragmented and complex shapes. Thus, it is reasonable to utilize the PLUS model to simulate the future urban land use pattern by considering transportation planning, since the simulation results can provide essential data support and decision-making bases to underpin future territorial space management and planning. [ABSTRACT FROM AUTHOR]

In order to study the effect of the replacement rate of recycled coarse aggregate, length-diameter ratio and diameter-thickness ratio on the axial compressive bearing capacity of middle long columns of recycled aggregate concrete with ferronickel slag filled steel tubes (RACFNSFST), the monotonic loading tests were carried out on eight RACFNSFST under axial compression. By comparing the calculation method of axial compressive capacity recommended by the domestic and foreign common concrete-filled steel tube codes, the prediction formula of axial compressive capacity is fitted by regression and compared with the test results. The results show that local buckling occurs at both ends of the medium and long column, which is the failure mode of material, and the long column is the failure mode of whole instability. The medium and long columns with the same reclaimed coarse aggregate substitution rate and section size have better bearing capacity and slower deflection growth than that of the long columns. With the increase of diameter-thickness ratio, the bearing capacity and ductility are reduced, and the hoop effect of steel tube on recycled concrete is obvious. The fitting formula is simple and practical, and it is in good agreement with the measured value. [ABSTRACT FROM AUTHOR]

The growth, survival rate, serum immunity and antioxidant enzymes, and economic benefits of Oplegnathus punctatus (350. 6±24. 3 g) reared in recirculating aquaculture system and offshore aquaculture net pen were investigated to evaluate the technical feasibility of the land-sea alternate mariculture model for Spotted knifejaw,Oplegnathus punctatus. Results showed that the average individual weight of Oplegnathus punctatus reached (547. 6±25. 2) g and the survival rates reached 95. 8% in the recirculating aquaculture system,while the average individual weight of Oplegnathus punctatus reached ( 735. 7 ± 27. 9) g and the survival rates reached 98. 3% in land-sea alternate aquaculture after 120 days culture. The contents of serum lysozyme (LZS),superoxide dismutase ( SOD),glutathione peroxidase (GSH-Px) and catalase ( CAT) in land-sea alternate aquaculture were significantly higher than those in recirculating aquaculture system (P<0. 05),40. 5%,43. 2%,42. 3% and 39. 8%,respectively. In addition,the net profit of land-sea alternate aquaculture was 128. 34% higher than that of recirculating aquaculture. The results indicated that the optimal growth performance, strong immunity, antioxidant activities and high economic benefits of Oplegnathus punctatus were obtained under the land-sea alternate aquaculture model,which provides the theoretical basis and data support for land-sea alternate aquaculture of Oplegnathus punctatus. [ABSTRACT FROM AUTHOR]

Objective·To investigate the periodontal health status of different age groups with type 2 diabetes mellitus, and to explore the influence of age on the prevalence of periodontitis in diabetic patients and the related risk factors. Methods·Periodontal examination and questionnaire survey were conducted on patients with type 2 diabetes mellitus who visited the Department of Endocrinology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University from November 2018 to December 2018. The periodontal indexes of index teeth were examined and scored, including probing depth, bleeding on probing, clinical attachment loss (CAL), calculus index (CI) and plaque index (PLI). According to the diagnostic criteria of periodontitis, the subjects were divided into periodontitis group and non-periodontitis group. The prevalence of periodontitis and related periodontal indexes in patients with type 2 diabetes mellitus of different ages were compared. Results·In the 916 patients with type 2 diabetes mellitus, the difference of age between the periodontitis group and non-periodontitis group was statistically significant (χ²=100.1, P=0.001). Multivariate Logistic regression analysis indicated that age was a high-risk factor for type 2 diabetic periodontitis (P=0.001, OR=2.13, 95%CI 1.79 ‒ 2.55). Compared with younger patients with diabetes mellitus, elderly patients with diabetes mellitus were more likely to have periodontal symptoms such as gingival bleeding (χ²=36.4, P=0.001), tooth loosening (χ²=25.9, P=0.002) and masticatory weakness (χ²=12.3, P=0.006). There were significant differences in PLI (χ²=8.3, P=0.041), CI (χ²=12.8, P= 0.005) and CAL (χ²=32.5, P=0.001) among diabetic patients of different ages. There were significant differences in periodontal health care measures, such as brushing teeth (χ²=18.8, P=0.001), rinsing mouth with water (χ²=21.8, P=0.001) and frequency of tooth brushing (χ²=24.0, P=0.001). Conclusion·The age of diabetic patients is a risk factor affecting the prevalence rate and severity of periodontitis. It is necessary to pay attention to the periodontal health of elderly diabetic patients and carry out targeted oral health care. [ABSTRACT FROM AUTHOR]

In order to explore the effect of gas explosion on the refuge chamber of coal mine, this paper carried out a numerical simulation on the process of gas explosion under the closed and open condition respectively. The physical model of the refuge chamber was established by means of applying the software of ICEM, and then Fluent software was used to carry out the numerical simulation on the pressure and temperature variation of gas explosion under different boundaries. In addition, The Origin software was used to carry out the curve fitting of the pressure as well as the temperature variation during the process of the gas explosion. The results show that under the sealing condition, the refuge chamber need withstand the high pressure of 0.61 MPa and the high temperature of 2269 K; under the condition of opening, the refuge chamber only need withstand the overpressure of 12.39 KPa and the high temperature of 1773 K respectively. Considering comprehensively the explosion overpressure and the high temperature, the position of the refuge chamber should be far away from the dead end roadway. [ABSTRACT FROM AUTHOR]

Aiming at the shortage of electricity Hubei power grid may face in the future, the present power supply situation and the future construction plan of were analyzed. A kind of mid-long term load forecasting method based on improved support vector machine (SVM) was put forward. Genetic algorithm (GA) was used to improve SVM, so that the optimal parameters can be automatically selected. The maximum load of Hubei grid during the "Thirteenth Five Year Plan" was predicted using the method proposed. On this basis,the power balance of Hubei grid was analyzed. The results indicate that the prediction accuracy of this method is 3. 66% higher compared with BP neural network. And there will be a year-round power gap in 2017 in Hubei power grid and the gap will reach to a serious cases of 1. 533 × 107 kW in 2020.Therefore,the construction of UHV must be accelerated during the period of "Thirteenth Five Year Plan". [ABSTRACT FROM AUTHOR]

Yangmu Formation in the bottom of Huangsong Group originally defined as Neoproterozoic exposes in the eastern Heilongjiang.LA-ICP-MS zircon U-Pb dating of two-mica quartz schist and late-stage gneissic monzogranite in Yangmu Formation of Huangsong Group was analyzed in order to restrain the depositional age and reveal the provenance.The results show that most of zircons from two-mica quartz schist,which is collected from typical section of Yangmu Formation,are of magmatic orgin,yielding isotopic ages from Paleozoic to Early Mesozoic with the peaks at 248,263,270,290,318,326,about 360,426 Ma,etc.,and the formation age of late-stage gneissic monzogranite intruding Yangmu Formation is(221±3)Ma;Yangmu Formation of Huangsong Group deposits during Early-Middle Triassic(221-248 Ma),rather than Neoproterozoic as previously believed.Based on the comparison between the age frequency of detrital zircons in Yangmu Formation and regional geochronological data,the sediment in Yangmu Formation of Huangsong Group is mainly from peripheral Late PaleozoicEarly Mesozoic terrane and minor Early Paleozoic terrane.Furthermore,the Neoproterozoic magmatic zircons identified prove that there might be Neoproterozoic magmatic event in the area,and Meso-Paleoproterozoic detrital zircons identified suggest that there might be ancient Precambrian remnants at or near the surface during Early Mesozoic. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of chronic intermittent cold exposure (CIC) on brown adipose tissue in mice and its mechanism. Methods: C57BL/6 mice were fed with high fat diet to establish obese mice model, and then treated with CIC. The animals were randomly divided into four groups consisting of six animals each: control group (Con group), chronic intermittent cold exposure group (CIC group), high fat group (HF group), high fat and cold exposure group (HF+CIC group). During CIC intervention, the body weight and anal temperature of mice were measured. After 16 weeks of CIC treatment, the mice were sacrificed by anesthesia and the brown adipose tissue was taken from the scapular area. The morphological changes of brown adipose tissue were observed by HE staining. Western blotting and q-PCR were used to detect the expression of Cirbp, PPAR-γ, C/EBP α, PGC-1 and UCP-1 in brown adipose tissue. Results: The results of rectal temperature changes showed that the rectal temperature difference of mice before and after cold exposure was large in the early stage of intervention. There was no significant difference in rectal temperature after cold adaptation. Compared with Con group, the body weight of mice in HF group increased, the proportion of brown fat in body weight decreased, the expression of Cirbp, PPAR-y and C/EBPα in brown adipose tissue increased, and the expression of PGC-1a and UCP-1 decreased (P< 0.05). Compared with HF group, the body weight of mice in HF+CIC group decreased, the proportion of brown adipose tissue in body weight increased, the expression of Cirbp, PPAR-γand C/EBPαin brown adipose tissue decreased, and the expression of PGC-1α and UCP-1 increased (P<0.05). Conclusion: CIC may affect the expression of PPAR-γ-PGC-1α-UCP-1 signaling pathway by activating Cirbp, thus affecting the activation of brown adipose tissue and preventing obesity. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of tripterygium wilfordii polyglycoside tablets combined with NB-UVB on inflammation level, blood lipid indexes and stroke risk in patients with psoriasis vulgaris. Methods: 72 patients with psoriasis vulgaris treated in our hospital from January 2020 to December 2021 were selected. According to the random number table method, 72 patients were divided into thematched group (n = 36) and observation group (n = 36). The matched group were treated with NB-UVB total body irradiation, while patients in observation group were treated with tripterygium wiltergium polyglycoside tablets on the basis of matched group. The treatment effect of the two groups was compared, the PASI score of the two groups before treatment and after treatment for 12weeks were compared, the serum levels of IL-22, IL-17, TNF-α and YKL-40 of the two groups before treatment and after treatment for12 weeks were compared, and the serum lipid levels of the two groups before treatment and after treatment for 12 weeks were compared. The degree of stroke risk at 12 weeks of treatment were compared between the two groups, and the incidence of adverse reactions during treatment were compared between the two groups. Results: The effectiveness of observation group 98.33% was higher than matched group 86.67% (P＜0.05). Before treatment, there was no difference in PASI score between the two groups (P＞0.05). After treatment for 12weeks, the PASI score of the two groups decreased, and the observation group was lower than the matched group (P＜0.05). Before treatment, there was no difference in serum levels of IL-22, IL-17, TNF-α and YKL-40 between the two groups. After treatment for 12weeks, the serum levels of IL-22, IL-17, TNF-α and YKL-40 in the two groups were decreased, and the observation group was lower than the matched group (P＜0.05). Before treatment, there was no difference in serum lipid levels between the two groups (P＞0.05). After treatment for 12 weeks, the levels of total cholesterol, triglyceride and low-density lipoprotein in the observation group were decreased, while the levels of high-density lipoprotein were significantly increased, and the comparison between the observation group and the matched group was significant (P＜0.05), while the comparison between the matched group and before treatment was not significant (P＞0.05). After treatment for 12 weeks, the risk of stroke in the observation group was lower than matched group (P＜0.05). During the treatment, both groups of patients completed the treatment without obvious adverse reactions. Conclusion: Compared with NB-UVB alone, tripterygium wilfordii polyglycoside tablets combined with NB-UVB can reduce the level of inflammation, improve the level of blood lipid, and reduce the risk of stroke in patients with psoriasis vulgaris. [ABSTRACT FROM AUTHOR]

Objective　 To investigate the effect of interfering with the expression of VEGF-C on the radiosensitivity of the nasopharyngeal carcinoma CNE-2 cell transplanted tumor and related signaling pathways. Methods　The mice with transplanted tumors of nasopharyngeal carcinoma CNE-2 were randomly divided into tumor body group，siRNA-NC group， siRNA-VEGF-C group; irradiation group；siRNA-NC+ irradiation group; siRNA-VEGF-C+irradiation group. Tumor growth was observed，and the protein expression of VEGF-C，ATM and P65 were detected by immunohistochemistry. Results　Interference of VEGF-C expression in nasopharyngeal carcinoma CNE-2 cell transplanted tumors showed significantly slower tumor growth after irradiation. Immunohistochemical test results showed that after tumor transplantation of mice interfered with VEGF-C，VEGFC and ATM were significantly decreased （ P < 0.05）， while P65 was increased （ P < 0.05） . After combined irradiation，VEGF-C and ATM were significantly decreased （P < 0.05）. Conclusion　In mouse nasopharyngeal carcinoma CNE-2 cell transplantation tumors，interfering with VEGF-C gene affects downstream ATM by activating NF-kB signaling pathway，thereby increasing the sensitivity of radiotherapy. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical efficacy and safety of direct mechanical thrombectomy in the treatment of acute anterior circulation large vessel occlusion ( aLVO) stroke. Methods 59 patients with acute occlusion of anterior circulation within 4. 5 hours were randomly divided into direct thrombolysis group ( n = 29 ) and intravenous thrombolysis combined with mechanical thrombolysis group ( n = 30) . The rates of vascular patency, good neurological prognosis 90 days after operation ( modified Rankin Scale score 0 - 2), symptomatic intracranial hemorrhage and death were analyzed and compared. Results There was no significant difference in the vascular patency rate( 89. 7% vs 90. 0%) and 90 day prognosis rate ( 41. 4% vs 43. 3%) between the two groups( all P > 0. 05 ) . There was no significant difference in the incidence of symptomatic intracranial hemorrhage ( 6. 90% vs 10. 0% ) and mortality ( 13. 8 % vs l 6. 7 % ) between the two groups( all P > 0. 05). Conclusions For patients with acute anterior circulation occlusion within 4. 5 hours, direct mechanical thrombectomy and bridging therapy have good efficacy and safety, and there is no significant difference between them. Direct mechanical thrombectomy can be used as an effective treatment for patients with acute anterior circulation occlusion. [ABSTRACT FROM AUTHOR]

Taking formed grinding wheel as research object, a double-coordinate electro-spark reshaping device is designed and developed with Pro E and Protel99 se, which can be used to reshape metal-based bonded diamond grinding wheel with arbitrary cross-section. The grinding wheel dresser of reshaping device adopts rotating electrode structure to reshape the formed grinding wheel, two-axis linkage stepping motor driven by control system impels double-coordinate worktable to finish the grinding wheel shaping trail of dresser. According to the polarity effect test results of electro-spark reshaping, appropriate discharge parameters are adopted: voltage is 120 V,current is 20 A, pulse duty cycle is 50%. Double-coordinate electro-spark reshaping device is used to dress metal-based bonded diamond grinding wheel. After being dressed, the grinding wheel is used to grind the alumina ceramic workpiece in the cut-in grinding test, setting the spindle speed of the grinder as 2 800 r/min, the feed speed of the grinder table as 5 m/min and the cut-in grinding depth as 4 μm. Test results show that the ideal overall arc groove profile of the workpiece is achieved, the deviation of the arc groove is less than 5 μm. It comes to conclusion that after being dressed by double-coordinate electro-spark reshaping device,the grinding wheel has certain shaping accuracy and it can be used to grind the workpiece. [ABSTRACT FROM AUTHOR]

Objective To detect the quantitative parameters of neovascularization in carotid plaques of patients with acute cerebral infarction using contrast-enhanced ultrasound (CEUS) and to evaluate the effect of ambient pressure around carotid plaques. Methods Six-two patients with large artery atherosclerosis stroke (LAAS) were recruited as the infarction group, and 54 patients with atherosclerosis who were age-and gender-matched without cerebrovascular events were selected as the control subjects. The advantage plaques were imaged by CEUS. The mean of time-intensity curve (TIC-M), the peak (FC-TP) and area under the curve (FC-AUC) obtained from fitting curves were analyzed off-line. Local pressure-systolic (Loc Psys) and pressure-diastolic (Loc Pdia) were obtained by software (quality arterial stiffness, QAS) for analyzing arterial stiffness. The correlations between parameters of contrast-enhanced ultrasound and local pressure were analyzed by Pearson correlation analysis. Results There was no significant difference in Loc Psys and Loc Pdia between the two groups. The TIC-M, PC-P and FC-AUC in the infarction group were significantly larger than those in the control group (all P<0.05). TIC-M was negatively correlated with Loc Psys and Loc Pdia, respectively (r=-0.470 and -0.682, all P<0.05). FC-P was negatively correlated with Loc Psys and Loc Pdia, respectively (r=-0.480 and -0.691, all P<0.05). There was a negative correlation between FC-AUC and Loc Pdia (r=0.493, P<0.05). Conclusions The parameters of neovascularization of carotid plaques were closely related to the ambient pressure around the plaque. The ambient pressure around the plaque should be considered when vulnerable plaques were assessed by CEUS. [ABSTRACT FROM AUTHOR]

Objective: The main aim of this study is to investigate the beneficial effects of mild chronic intermittent cold(CIC)exposure on the effects of high-fat diet feeding(HFD) on liver oxidative stress in SD rats. Methods: Mild CIC has been widely used to establish the animal model of cold adaptation. HFD(45% of fat) and CIC(4℃, 6 hours/day) were given concurrently to the rats for 4 weeks. The rectal temperature, body weight, liver weight, the levels of ATP and reactive oxygen species(ROS) in liver are measured after 4 weeks of rats exposed to mild CIC and/or HFD. The protein level of cold inducible RNA binding protein(Cirbp) and thioredoxin(TRX) are detected by western blotting. Results: Compared with the control group, the body weight of the high fat diet group increases significantly, the ROS level increases significantly, and the level of ATP has no significant effect; the rectal temperature of rats decreases significantly after 1 d and 1 w of CIC exposure, while the rectal temperature has no significant difference after CIC exposure of 2 w, 3 w and 4 w; there's no significant difference in the level of ROS, but the ATP level and the expression of Cirbp and TRX are increased significantly. Compared with HFD group under normal temperature, the body weight decreases significantly after CIC exposure 4 w, the level of ROS had no significant difference, while ATP level increased significantly; the expression of Cirbp and TRX increased significantly. These results suggest that cold adaptation enhances the antioxidant level in the liver of HFD rats, probably due to the increased expression of Cirbp after cold acclimation, and then increases the expression of the antioxidant protein TRX, thus cleaning ROS. Conclusion: Cold adaptation induced by CIC exposure protects the liver against oxidative stress induced by HFD. [ABSTRACT FROM AUTHOR]

Objective: The liver plays an important role in human body. At the same time, the liver has strong ability of regeneration. In the present study, we observed the changes of reactive oxygen species(ROS) and mitochondrial metabolism during liver regeneration after liver partial hepatectomy in order to provide new targets for future regulation of liver regeneration. Methods: Using the classic mouse 70 % partial hepatectomy model, the male healthy Balb/c mice were randomly divided into Sham group and 70 % partial hepatectomy group(70 % PH). The liver tissues were harvested at 6 h, 1 d, 2 d, 3 d, 5 d and 7 d. The frozen sections were used to detect the level of ROS. The expression of the cell proliferation-related proteins PCNA, Cyclin D1; the cell antioxidant enzymes related proteins SOD1, SOD2, CAT, GPX1, and the mitochondrial biogenesis and dynamics regulators PGC-1α, Nrf1, TFAM, Drp1, Fis1, Mfn1, Mfn2,OPA1 were determinated by Western blot respectively. Results: The liver of mice regenerated rapidly after 70 % hepatectomy, and the expression of the cell proliferation-related proteins PCNA and Cyclin D1 increased significantly. During the process, the level of ROS firstly increased and then decreased. The protein levels of antioxidant enzymes SOD1, SOD2, CAT, and Gpx1 were consistent with the change of ROS level. The mitochondrial biogenesis regulatory factors PGC-1α, Nrf1 and TFAM firstly decreased and then increased. The mitochondrial fission protein levels of Drp1 and Fis1 decreased firstly and then increased significantly with the mitochondrial fusion protein levels of Mfn1, Mfn2 and OPA1 decreased and then restored to the normal level during the regeneration process. Conclusions: In the regeneration process after 70 % liver hepatectomy in mice, the ROS level increased accompanied with the high levels of antioxidant proteins. The mitochondrial biogenesis increased while the mitochondrial fission/fusion balance moved towards fission. These changes are likely to be important potential intervention targets for the regulation of liver regeneration in the future. [ABSTRACT FROM AUTHOR]

Preventive medicine is an essential part of the modern medical systems and plays a key role in improving public health. In order to carry out preventive medical work in the future, preventive medical undergraduate students not only need to master preventive medical knowledge solidly but also know clinical medical fundamental knowledge well. Clinical practice is the main method for medical students to strengthen clinical theoretical knowledge and transform it into practice, which plays an important role in the cultivation of preventive medical undergraduate students. According to the explorations and reforms for several years, we have accumulated much experience in the cultivation of preventive medical undergraduate students. However, there still are some problems at the present stage. The objective of this review is to improve the educational quality by analyzing some problems in the clinical practice of preventive medical undergraduate students as well as making some beneficial suggestions. [ABSTRACT FROM AUTHOR]

Objective To investigate the changes and clinical significance of deceleration capacity of rate(DC) in patients with paroxysmal atrial fibrillation(PAF). Methods Ninety patients diagnosed with PAF(PAF group) were selected from the inpatients in our hospital from January 2015 to October 2016 while 133 healthy subjects were selected as control group. They underwent 24-hour ambulatory electrocardiography and echocardiography examinations. Between the two groups, their DC, acceleration capacity of heart rate(AC), heart rate variability(HRV), left atrial diameter(LAD) and left ventricular ejection fraction(LVEF) were compared and analyzed. [WTHZ]Results(ⅰ) Compared with the control group, DC value, absolute value of AC, SDNN, rMSSD and LAD all significantly increased in PAF group(P<0.05) while the 24hour average heart rate and LF/HF both significantly decreased(P<0.05). (ⅱ) There was no significant difference of DC value between males and females in either group. However, if compared with the same sex in the control group, DC value of males in PAF group significantly increased(P<0.05) while the value showed an increasing trend in females. (ⅲ) Whether in the control group or in PAF group, DC value was negatively correlated with age(r<－0.262 vs. r<－0.548，P<0.01). If compared with those in the same age subgroup of the control group, the DC value of the patients younger than 60 years old in PAF group significantly increased(P<0.05) while the value showed an increasing trend in those older than 60 years old. (ⅳ) The LAD value of patients in PAF group was significantly higher than that in control group(P<0.05). However, the DC values in PAF group were both significantly higher than those in control group(P<0.05) whether for those with LAD≤40 mm or those with LAD>40 mm. Conclusion Increased DC value in PAF patients suggests increased tension of vagus nerve. The index is negatively correlated with age of patients. [ABSTRACT FROM AUTHOR]

Objective: To study the influence and Novel Function mechanism of micro RNA-195 in the process of Glucose Uptake Disorder Induced By PA in Human Liver Cell L02. Methods: Human Liver Cell L02 was cultured in vitro and treated with different concentrations of PA(0.6 mmol/L, 1 mmol/L) for 10 h.The morphological changes of Human Liver Cell L02 were detected by microscope. GOD-POD detect the rest glucose content in cell culture, the expression levels of miR-195 was analyzed by Real time-PCR after induced by PA. Measured fluorescence intensity by Laser confocal scanning microscopy, and the change of glucose uptake by up-regulated and down-regulated of miR-195.Results: High concentration PA could induced Liver Cell L02 Glucose Uptake Disorder, the glucose content increased 2.5 mmol/L, and miR-195 over-expressioned.After transfection of miR-195 mimics, the expression of miR-195 up-regulated, and transfection of miR-195 inhibitor the expression of miR-195 down regulated. The concentration of glucose in cell culture was increased 2.5 mmol/L when miR-195 over-expressioned, that is to say glucose uptake reduced.The concentration of glucose decreased 1mmol/L in cell culture decreased when miR-195 low-expressioned. Conclusions: miR-195 is very likely to regulate the disorder of glucose uptaken in. [ABSTRACT FROM AUTHOR]

[Objectives]Ascorbate peroxidase(APX)removes excess plant peroxides by using an electron donor from ascorbic acid,which is an essential mechanism in response to abiotic stress. The aim of the paper is to study the response of DcAPX gene in the process of resisitance to abiotic stress. [Methods]The DcAPX gene was cloned from carrot variety‘Kurodagosun’. Expression profiles under high and low temperature,drought,and salinity treatments were performed to further understand the roles of the gene in response to abiotic stress in carrot. The gene was submitted to GenBank and the accession number is KR364573. [Results]Sequence analysis indicated that the length of DcAPX gene was 753 bp,which encoded 250 amino acids. It is predicted that the relative molecular mass of its protein was 27.76×103,and pI was 5.65. Amino acid sequence comparison showed that the evolutionary relationship of DcAPX from carrot was close to Pimpinella brachycarpa,which both belong to the Apiaceae family. Structure analysis showed that DcAPX was made up of 38.40% alpha helix,10.40% extended strand,and 51.20% random coil. Analysis on three-dimension structure implied that the enzyme was composed of 10 alpha helixes and 4 beta sheets. Quantitative real-time PCR analysis demonstrated that carrot DcAPX gene was tissue-specific,and had the highest expression level in the leaf. [Conclusions]DcAPX gene was significantly induced by abiotic stress,and the gene may play important roles in resistance against abiotic stress. [ABSTRACT FROM AUTHOR]

Metformin is one of the most commonly used drugs for the treatment of type 2 diabetes (T2DM), with the advantages of convenient use, good efficacy, safety, inexpensive and small side effects. Epidemiological studies suggest that metformin may reduce the cancer risks and overall cancer mortality. Recent studies in vitro and in vivo indicate that metformin inhibits cancer cell growth and reduces cancer risk. However, the molecular mechanisms underlying its effects on cancer are not clear yet, mainly including insulin-IGF axis, AMPK pathway, regulation of micro RNAs expression, caspase family activation, blockage of AGE-RAGE system, and et al. These molecular mechanisms may provide an important theoretical basis for metformin to prevent and treat cancer in the future. Here, we pooled data currently available to comprehensively review the antitumor effects and the molecular mechanisms of metformin, an antidiabetic drug. [ABSTRACT FROM AUTHOR]

Objective: To explore the effects and existing problems of PBL implemented on the Nutrition and Food Hygiene teaching, and to evaluate the results of PBL. Methods: To divide the students into the PBL teaching group (students of five-year program Nutriology, 2012 year) and the traditional teaching group (students of five-year program clinical medicine, 2011 year) randomly, and to evaluate the teaching effects by the examinational test and the questionnaire survey (including three questionnaires: student's satisfaction questionnaire, the way of problem-resolving questionnaire and a learning interesting/motivation questionnaire). Results: Compared with traditional teaching pattern, PBL teaching pattern actually has better effects on improving test scores, student satisfaction index, the learning interesting/motivation, and problem-solving way. Conclusion: PBL is a successful teaching method for five-years' program military students which could improve the teaching quality and enhance the capabilities of students, as well as strengthen the intrests of learning, that is worth of further promoted. [ABSTRACT FROM AUTHOR]

Objective: To analysis the effect of blood glucose level on liver function and blood lipid in type Ⅱ diabetes mellitus patients. Methods: 408 patients newly diagnosed with type Ⅱ diabetes mellitus aged from 14 to 89 years from November 2013 to May2014 were collected. All patients were divided into three groups according to the concentration of fasting plasma glucose(FPG)(group A, the FPG<8.0 mmol/L; group B, 8.0mmol/L≤FPG<11.0 mmol/L, group C, FPG≥11.0 mmol/L). The liver function and blood lipids were detected, then analysis for the influence and statistical significance between liver function, blood lipid and type Ⅱ diabetes mellitus patients’ blood glucose level were performed by SPSS 17.0. Results: Compared with group A and group B, group C was more obvious in the rise of ALT, AST(P<0.05), characterized by a significant rise in liver enzymes and bilirubin(P<0.05),and GLB level had significant increase(P<0.05); TC and TG level were abnormal(P<0.05). Conclusions: TypeⅡ diabetes mellitus patients with higher blood glucose level can cause more serious liver damage and dyslipidemia. The surveillance and control of blood glucose have an important significance for the health of the typeⅡ diabetes mellitus patients. [ABSTRACT FROM AUTHOR]

Objective: To study the influence of Eicosa Pentaenoic Acid(EPA) on the apoptotic, the regulation of h TERT and telomerase activity of human hepatocarcinoma SMMC-7721 cell. Methods: Human hepatocarcinoma SMMC-7721 cell was cultured in vitro and treated with different concentrations of EPA(0 μM, 25 μM, 50 μM, 100 μM, 200 μM) for 24 h, 48 h, 72 h. The morphological changes of SMMC-7721 hepatoma cell were detected by microscope. MTT assay was explored to detect the proliferation of SMMC-7721cells; The expression levels of h TERT, Bcl-2 and Bax protein were detected by Western blotting; The expression levels of SMMC-7721 cell h TERT m RNA were analyzed by Real time-PCR; ELISA was used to detect SMMC-7721 cell telomerase activity levels. Results:EPA induced SMMC-7721 cells apoptosis significantly, and the apoptosis rate was both in time-and dose-dependent manner. Western blotting showed that expression levels of h TERT and Bcl-2 protein was down-regulated and expression levels of Bax protein was up-regulated concurrently along with the apoptotic process, and the expression of h TERT m RNA as well as activity of telomerase decreased concurrently. Conclusions: EPA can restrain the activity of telomerase and induce death of SMMC-7721 cancer cells by inhibiting the expression of h TERT m RNA, it may be one of the anti-cancer mechanisms of EPA. [ABSTRACT FROM AUTHOR]

Objective To explore and identify functional symptoms of the lung system in traditional Chinese Medicine. Methods Based on the Symptom-mechanism Database of Traditional Chinese Medicine, the authors screened all the symptoms that can be explained only by the abnormal functions of the lung system with reference to the specific functions and anatomical location of the lung system. Results Specific symptoms of the lung system include sneezing, more expiration and less inspiration, more inspiration and less expiration, tachypnea, dyspnea, rough breath, weak breath, faint voice, loud voice, muffled voice, cough, faint cough, muffled cough, hoarseness, shortness of breath, hidrosis, hypohidrosis, adiaphoresis, spontaneous perspiration, and night sweating. Conclusion Specific functions of the lung system with mechanism that can be explained only by the abnormal functions of the lung system are the most significant evidence for identifying functional symptoms of the lung system. All symptoms above indicate abnormality of the lung system. Functions of the lung system in Tradinonal Chinese Medicine correspond to the interactive functions of the respiratory system, sweat glands and neuroendocrine system. [ABSTRACT FROM AUTHOR]

目的　观察肥胖大鼠心外膜脂肪（ＥＡＴ）组织中巨噬细胞计数变化。方法　选择２０只成年雄性ＳＤ大 鼠，随机分为对照组１０只和肥胖组１０只；对照组饲以基础饲料，实验组饲以高脂饲料。饲养８０ｄ后将两组大鼠处 死并取其ＥＡＴ、附睾周围脂肪、腹股沟脂肪组织，ＥＡＴ称重。采用免疫组化染色法对ＥＡＴ、附睾周围脂肪、腹股沟脂 肪组织的巨噬细胞（Ｍ）、Ｍ１、Ｍ２进行计数。结果　肥胖组ＥＡＴ组织质量为（０．４５±０．２０）ｇ，对照组为（０．３０± ０．１４）ｇ，两组相比，Ｐ＜０．０５。对照组三个部位脂肪组织中的Ｍ、Ｍ１、Ｍ２计数及Ｍ１／Ｍ、Ｍ２／Ｍ、Ｍ１／Ｍ２相比，Ｐ均＞ ０．０５；肥胖组ＥＡＴ组织、附睾周围脂肪组织中的Ｍ、Ｍ１、Ｍ２计数及Ｍ１／Ｍ、Ｍ１／Ｍ２、Ｍ２／Ｍ与腹股沟脂肪组织相比，Ｐ 均＜０．０５；肥胖组ＥＡＴ组织中的Ｍ、Ｍ１、Ｍ２计数及Ｍ１／Ｍ、Ｍ１／Ｍ２、Ｍ２／Ｍ与附睾周围脂肪组织相比，Ｐ均＞０．０５； 肥胖组ＥＡＴ组织中的Ｍ、Ｍ１、Ｍ２计数及Ｍ１／Ｍ、Ｍ１／Ｍ２、Ｍ２／Ｍ与对照组相比，Ｐ均＜０．０５。结论　肥胖大鼠具有 更多的ＥＡＴ组织，其ＥＡＴ组织中Ｍ数量增多，但Ｍ２数量相对减少。 [ABSTRACT FROM AUTHOR]