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为解决新能源市场化的规模及路径问题，着眼于省级电网的现状及市场化边界条件，建立了新能源市场化规模测算模型。首先，考虑各省电网的新能源保障性利用小时数、居民农业保障用电、可再生能源消纳权重等因素，提出了5种新能源市场化边界的测算方法，以确定省级电网的新能源入市边界。在此基础上，建立了新能源最佳入市路径测算模型，以社会总收益最大化为目标，综合考虑新能源市场化所带来的各项收益及成本，在市场化边界内寻求省级电网的新能源市场化最佳规模。从而在电力体制改革的新形势下，保障新能源项目收益，满足市场化边界，有力推动新能源逐步参与电力市场。

目的探讨表达M2型小胶质细胞标志物精氨酸酶1（Arginase1，Arg1）敲低对阿尔茨海默病模型小鼠（APP/PS1）认知功能的影响。方法采用Arginase1基因工程小鼠，分为C57BL/6对照组（WT）、Arginase1低表达组（Arg1+/-）、阿尔茨海默病小鼠模型组（APP/PS1）、Arginase1、APP/PS1转基因小鼠Arginase1低表达组（Arg1+/-；APP/PS1），旷场实验（OFT）、Morris水迷宫（MWM）实验分别测试小鼠自主活动和适应能力、学习记忆能力，硫磺素S染色法和免疫荧光染色法检测小鼠脑内β-淀粉样蛋白（Aβ）沉积；小鼠海马区域Arginase1，小胶质细胞特征性标志物离子钙接头蛋白分子1（Iba1）、跨膜蛋白119（Tmem119）及溶酶体蛋白（CD68）表达量；ELISA法检测海马和皮质组织Aβ1-40、Aβ1-42表达量，蛋白免疫印迹（Western blot）法检测淀粉样蛋白前体蛋白 （APP）、APP-β位点剪切酶（BACE）、脑啡肽酶（NEP）、白细胞介素-1β（IL-1β）表达量。结果OFT结果显示，与APP/PS1组比较Arg1+/-；APP/PS1组在中央格区域的持续时间和运动频率明显增高（P+/-；APP/PS1组小鼠逃避潜伏期明显减少（PP+/-；APP/PS1组海马区域Aβ水平显著降低（P+/-；APP/PS1组海马区域小胶质细胞表达CD68增多（P=0.039 2，P=0.000 3）；ELISA与Western blot结果显示，与APP/PS1组比较，Arg1+/-；APP/PS1组Aβ1-40、Aβ1-42、APP、IL-1β水平下降，NEP蛋白表达量增加（PP=0.497 7）。结论在APP/PS1模型小鼠中，下调Arginase1可能促进脑内小胶质细胞激活，上调Aβ降解酶NEP水平，减少脑内Aβ沉积和神经炎症，从而提高AD模型小鼠空间学习能力。

目的探讨小鼠的杏仁核中C1q/C3补体系统在诱导抑郁样行为过程中的作用途径。方法本实验分3部分：① 采用慢性束缚压力方法建立小鼠抑郁模型，将12只8周龄雄性C57BL/6小鼠随机分为对照（WT）组和抑郁模型（CRS）组，各6只，抑郁模型组造模2周。行为学测试系统悬尾实验（TST）、强迫游泳实验（FST）测试小鼠抑郁状态，采用免疫荧光染色法检测小鼠杏仁核中突触素（Syn）和突触后致密物（PSD95）变化情况，小胶质细胞（Iba-1）和星形胶质细胞（GFAP）细胞荧光强度，C1q、C3含量。② 6只8周CX3CR1-GFP雄性鼠，随机分为GFP组以及GFP模型（GFP+CRS）组，各3只，采用免疫荧光染色法观察小胶质细胞及星形胶质细胞相互作用情况。③ 12只8周龄雄性C57BL/6和12只C1q-/-小鼠随机分为对照（WT）组，抑郁模型（CRS）组，C1q敲除（C1q-/-）组，C1q敲除模型（C1q-/-+CRS）组，各6只，模型组组造模2周，行为学TST、FST检测4组小鼠抑郁状态，采用免疫荧光染色法检测四组小鼠杏仁核部位突触Syn和PSD95变化。结果行为学分析结果显示：与WT组比较CRS组在TST和FST中不动时间明显升高（PPP=0.003 8）；与WT组比较CRS组杏仁核内Iba-1和GFAP明显激活（P=0.000 4， P=0.003）且与WT组比较CRS组杏仁核内小胶质细胞与星形胶质细胞相互作用明显；与WT组比较CRS组杏仁核内C1q与C3产生明显增多（P=0.000 2， P=0.011 9）；行为学分析，WT、CRS、C1q-/-、C1q-/-+CRS 4组综合比较，在TST中，与CRS组比较，WT组不动时间明显升高，C1q-/-+CRS组不动时间也明显增高（均PC1q-/-+CRS组不动时间也明显增高（均P<0.001）； 与CRS组比较WT组与C1q-/-+CRS组杏仁核内突触Syn明显增多（PPPC1q基因缺陷阻断CRS诱导的小鼠突触丢失和抑郁样行为。

目的探讨外周免疫对脑膜淋巴管结构的影响。方法通过尾静脉给Nude裸鼠回输卡介苗激活的CD3+的T淋巴细胞，建立免疫重构模型小鼠；回输等体积的PBS作为对照组；BALB/c小鼠作为野生型组。采用免疫荧光染色法检测小鼠硬脑膜lyve-1+的淋巴管内皮细胞连续程度对淋巴管结构进行评估，检测硬脑膜淋巴管内CD11b+细胞的数量来反映免疫细胞迁入淋巴管的程度。结果免疫荧光染色的结果显示：与BALB/c小鼠相比，裸鼠背侧淋巴管内CD11b+细胞数量降低（P＜0.05）。回输T淋巴细胞后裸鼠的脑膜淋巴管较对照组有明显的增殖。裸鼠颈部淋巴结副皮质区淋巴小结增生，皮质区无明显差异。结论外周免疫调节可改善脑膜淋巴管的结构及功能。

【目的】探讨采用大剂量甲氨蝶呤(MTX)预防性治疗中枢神经系统白血病(CNSL)对急性淋巴细胞白血病 (ALL)儿童智力与行为的影响。【方法】①按“ 中国-比内智力测验手册” 方法对42 例ALL 患儿在治疗前后与40 例正常儿童 进行测试比较;②根据自制行为量表对ALL 患儿治疗前后进行行为比较。【结果】①ALL 患儿治疗前IQ 、行为与对照组无差 异(P >0.05), 而治疗后IQ 明显低于对照组, (P

【目的】探讨人巨细胞病毒(HCMV)对红系祖细胞(CFU-E)的分化和增殖的影响, 并初步探讨其作用机制。【方 法】取15 例脐血标本, 用红系祖细胞单向半固体培养技术, 观察3 种不同浓度的HCMV AD169 株对CFU-E 集落形成的影 响, 用PCR 和RT-PCR 检测集落中的HCM V DNA 与la te mRNA 。【结果】3 个感染组的CFU-E 均减少, 与正常对照组比较, 分别为11.46%、21.88 %、34.45 %(P

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Breast cancer harbors a distinctive microbial community that significantly differs in quantity and diversity from normal breast tissue, benign breast diseases, and adjacent non⁃cancerous tissues. Moreover, the microbial composition varies among different molecular subtypes, grades, and stages of breast cancer. This suggests that the breast cancer⁃associated microbiota play an important role in the initiation, progression, and treatment of breast cancer. Nevertheless, due to factors such as ethnic and geographical disparities, sample sizes, and sequencing depths, there are discrepancies in current research results, and there is a lack of comprehensive reviews. Therefore, this paper summarizes the latest research progress on microbiota sequencing in breast cancer, systematically analyzes the differences in microbial composition between breast cancer tissues and non⁃cancerous tissues, and between different molecular subtypes, pathological grades and stages of breast cancer, and discusses the roles of microbiota in the diagnosis and treatment of breast cancer, with the aim of providing a new perspective for the future diagnosis and treatment of breast cancer based on microbiota. [ABSTRACT FROM AUTHOR]

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This experiment was conducted to investigate the effects of adding different levels of vitamin E to the diet on the growth performance, immune function, and meat quality of Guizhou black goats. Forty-four Guizhou black goats with an average body weight of (21.66±1.64) kg were selected for the experiment. They were divided into 4 groups with 11 goats in each group. The vitamin E supplementation levels for control group, group 1, group 2, and group 3 were 0, 50, 250 mg/(kid·d) and 500 mg/(kid·d), respectively. The pre-trial period was 7 days, and the formal period was 120 days. The feed intake of black goats in each group was measured every day, and the weight of black goats in each group was measured every 30 days. After the experiment, the average daily feed intake (ADFI) and average daily gain (ADG) of black goats in each group were calculated. At the same time, the blood of black goats in each group was collected to determine the serum immune indexes, and 3 black goats were randomly selected for slaughter. The content of amino acid and fatty acid in muscle were determined. The results showed that compared with the control group, the ADG of group 2 was increased by 16.23%, and the contents of immune factors were also higher, among which IgA and IgG were signifi‐ cantly higher than those of the control group (P<0.05); the muscle shear force and drip loss of group 2 were significantly lower than those of the control group (P<0.05), and the contents of crude protein, poly‐ unsaturated fatty acids, oleic acid and linoleic acid were significantly higher than those of the control group (P<0.05). In conclusion, adding 250 mg/(kid·d) of vitamin E has the best effect on improving the growth performance, immune function, and meat quality of Guizhou black goats. [ABSTRACT FROM AUTHOR]

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