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The quality issues commonly found in original medical images, such as insufficient contrast, blurred details, and noise interference, make it difficult for existing medical image segmentation techniques to achieve new breakthroughs. This study focused on the enhancement of medical image data. Without significantly altering the appearance of the image, it improved the quality problems of the original image by adding specific pixel compensation and making subtle image adjustments, thereby enhancing the accuracy of image segmentation. Firstly, it introduced a new optimizer module, which generated a continuous distribution space as the target domain for transfer. This optimizer module took the labels of the dataset as input and mapped the discrete label data to the continuous distribution of medical images. Secondly, it proposed an EnGAN model based on generative adversarial networks (GAN), and used the transfer target domain generated by the optimizer module to guide the target generation of the adversarial network, thereby implanting the knowledge of improving medical image quality into the model to achieve image enhancement. Based on the COVID-19 dataset, convolutional neural networks, including U-Net, U-Net + ResNet34, U-Net + Attn Res U-Net, were utilized as the backbone network in the experiment, and the Dice coefficient and intersection over union reached 73.5% and 69.3%, 75.1% and 70.5%, and 75.2% and 70.3% respectively. The empirical results demonstrate that the proposed medical image quality enhancement technology effectively improves the accuracy of segmentation while retaining the original features to the greatest extent, providing a more robust and efficient solution for subsequent medical image processing research. [ABSTRACT FROM AUTHOR]

Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shanghai Land & Resources / Shanghai Guotu Ziyuan is the property of Editorial Board of Shanghai Land & Resources and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Geology / Gongcheng Dizhi Xuebao is the property of Journal of Engineering Geology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Pharmaceutical Practice & Service is the property of Journal of Pharmaceutical Practice Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai University / Shanghai Daxue Xuebao is the property of Journal of Shanghai University (Natural Sciences) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The fractures in the Yanchang Formation of the Zhenjing oilfield in the Ordos Basin are dense sandstone fractures, and accurate identification of the fracture infill can help to better evaluate and develop the dense sandstone reservoir. Using core data, imaging logging data and conventional logging data of the Yanchang Formation, the fracture production, filling minerals and filling conditions were counted, and the main lithologies of the fractures were determined to be fine sandstone and siltstone, with calcite as the main filler. The logging response characteristics of filled and unfilled fractures were summarized by means of rendezvous plots and normal distributions, and the logging response differences between filled and unfilled fractures were compared to select fracture-sensitive logging parameters, constructing the curve change amplitude parameter and curve change rate parameter, and then constructing a comprehensive index identification method for fractures with and without filling. The results show that there is a significant difference between the response of induction logs to fracture filled and unfilled, some difference in the response of porosity logs to fracture filled and unfilled, and the least significant difference in the response of lithology logs. The response characteristics and identification method was applied to two wells, and the combined identification rate of fractured and unfilled wells was 76%. The results show that the response characteristics and identification method can provide new ideas for fracture filling evaluation in dense sandstones and improve the evaluation method for fractured dense sandstone reservoirs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Endothelial progenitor cells play an important role in vascular endothelial renewal and repair. The transplantation of autologous endothelial progenitor cells expanded and cultured in vitro to promote angiogenesis in ischemic sites has become a new strategy for the prevention and treatment of ischemic cardiovascular diseases. However, the endothelial progenitor cells derived from the elderly body will show signs of cellular senescence when expanded in vitro. The ability of aging endothelial progenitor cells to repair vascular endothelium is difficult to exert. Studies have shown that DNA damage is closely related to cell aging, and DNA damage detection points are an important checkpoint for regulating DNA damage. OBJECTIVE: Lentiviral RNA interference technology was used to knockdown ATM and Rad3-related kinase (ATR) gene in rat bone marrow endothelial progenitor cells, and to explore its role in the aging process of endothelial progenitor cells. METHODS: Endothelial progenitor cells from bone marrow in rats were isolated, cultured and identified. After the isolated endothelial progenitor cells were cultured to the third generation, they were counted and randomly divided into three groups: non-infection control group (blank group), negative control group, and gene knockdown group (ATR-RNAi group). The non-infection control group was cultured normally, and the negative control group and gene knockdown group were stably transfected with lentiviral RNAi and lentiviral ATR-RNAi to day 3 and day 6, respectively. The level of ATR mRNA in each group of cells was detected by qRT-PCR. The protein expression of ATR in each group of cells was detected by western blotting. The senescence of each group of cells was detected by β-galactosidase staining. MTT colorimetric method was used to detect cell proliferation activity in each group. Transwell chamber and in vitro angiogenesis kit were used to detect cell migration ability and tubule formation of each group. Flow cytometry was applied to detect the cell cycle change in each group. RESULTS AND CONCLUSION: (1) Compared with the non-infection control group, the expression levels of ATR mRNA and ATR protein in the endothelial progenitor cells in ATR-RNAi group were decreased significantly (P < 0.01), indicating that ATR gene expression was effectively reduced. (2) Compared with the non-infection control group, the number of blue-stained cells in the ATR-RNAi group decreased, indicating that the degree of aging was significantly reduced (P < 0.01). (3) Compared with the non-infection control group, cell proliferation, migration and tubule formation in the ATR-RNAi group were significantly enhanced (P < 0.05). (4) Compared with the non-infection control group, the percentages of cells in the G1 and G2 phases in the ATR-RNAi group were decreased significantly, and the percentage of cells in the S phase was increased significantly (P < 0.05). (5) These results indicate that knockdown of the expression of ATR genes could delay the aging process of endothelial progenitor cells, promotes the function of endothelial progenitor cells, and reduces the stagnation of cell cycles. [ABSTRACT FROM AUTHOR]

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Pharmaceutical Practice & Service is the property of Journal of Pharmaceutical Practice Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Pharmaceutical Practice & Service is the property of Journal of Pharmaceutical Practice Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Geology / Gongcheng Dizhi Xuebao is the property of Journal of Engineering Geology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Geology / Gongcheng Dizhi Xuebao is the property of Journal of Engineering Geology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrogeology & Engineering Geology / Shuiwendizhi Gongchengdizhi is the property of Hydrogeology & Engineering Geology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To study the pharmacokinetics of HMS-01 in rats and provide support for subsequent study. Methods　A sensitive and specific method for the determination of HMS-01 in plasma and other biological samples was established by LC-MS/MS. The pharmacokinetics of HMS-01 in rats was studied by the established method. The pharmacokinetics of one dose of single intragastric administration and one dose of single intravenous administration in SD rats were studied, and the basic pharmacokinetic parameters were obtained. Results　After intravenous injection of 1 mg/kg HMS-01, the area under the plasma concentration-time curve AUC0-t of male and female rats was 221 ng·h/ml and 409 ng·h/ml, respectively. The average clearance rates were 4.53 L/h·kg and 2.41 L/h·kg, respectively. The average plasma elimination half-lives were 0.786 h and 1.27 h, and the apparent distribution volume was 5.13 L/kg and 3.82 L/kg, respectively. After intragastric administration of 30 mg/kg HMS- 01, the peak time of plasma concentration in rats was 1.17 h, the peak concentration of Cmax was 1 243 ng/ml, and the elimination half-life t1/2 was 2.00 h. The AUC0-t of male and female rats was 2 271 and 8 529 ng·h/ml respectively, and their bioavailability was 34.3% and 69.5% respectively. Conclusion　The pharmacokinetics of HMS-01 in rats has significant gender differences. It is well absorbed orally, and the bioavailability of HMS-01 in females is much higher than that in males. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Frequent itemsets mining for uncertain data has been studied extensively. For uncertain data which recorded private information of users, an attacker made use of background knowledge to obtain private information of users by analyzing frequent itemsets mined from uncertain data. In this regard, this paper proposed a new algorithm, denoted as FIMUDDP (frequent itemsets mining for uncertain data based on differential privacy) , to mine the top K most frequent itemsets based on expected support from uncertain data and satisfy differential privacy. FIMUDDP algorithm applied exponential mechanism and Laplace mechanism in differential privacy to ensure differential privacy for the top K most frequent itemsets based on expected supports of these frequent itemsets respectively. Finally, through analyzing FIMUDDP from theory and experiment evaluation, the results demonstrate the effectiveness of FIMUDDP. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation analysis of neutrophil to lymphocyte ratio (NLK)and platelet to lymphocyte ratio (PLR) with adult onset disease. Methods A retrospective method was adopted in this study. Fifty patients in the Affiliated Hospital of Southwest Medical University from July 2013 to August 2017 was collected and divided into uninfected group (27 cases)and infected group (23 cases) according to the infection. In addition,47 patients were selected as the control group. The relevant parameters of blood routine, ESR, and CRP are analyzed. Result Compared with controls, NLR and PLR were significantly higher in AOSD groups whether or not with infection, NLR in infected group were significantly higher than that in the uninfected group (P<0.05). NLR and PLR have a positive correlation with AOSD systemic score, both NLR and PLR in AOSD uninfected were positively correlated with CRP and ESR respectively. NLR value of 10.86 (sensitivity 65.2%, specificity 77.8%) was maximum diagnostic efficacy when forecast AOSD whether or not with infection. Conclusion NLR and PLR can he used as indicators for the condition and inflammatory activity in AOSD,and NLR have the diagnostic efficacy when judge AOSD whether or not with infection. [ABSTRACT FROM AUTHOR]

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨粪便钙卫蛋白对儿童溃疡性结肠炎(UC)诊断及治疗的指导作用。方法 选取UC患儿57例(UC组),单纯腹泻患儿30例(腹泻组),健康儿童60例(健康对照组)。留取粪便,采用ELISA法检测钙卫蛋白。 UC组采用“升阶梯”方案(美沙拉嗪无效时加用激素,继而加用单克隆抗体)治疗,比较治疗前后粪便钙卫蛋白变化,分析钙卫蛋白诊断UC的效能及其与治疗的关系。结果 UC组、腹泻组、健康对照组中位粪便钙卫蛋白分别为307.93、124.95和19.17μg/g,UC组明显高于腹泻组和健康对照组(P均<0.01),腹泻组与健康对照组比较无统计学差异(P>0.05)；UC组活动期、缓解期患儿中位粪便钙卫蛋白分别为333.53、273.50μg/g,P<0.05；ROC曲线分析显示粪便钙卫蛋白升高的临界值为175.53μg/g,对应诊断UC的最佳灵敏度和特异度分别为77.2%和87.9%。 UC组治疗后活动期患儿中位粪便钙卫蛋白明显下降；中位粪便钙卫蛋白≥307.93μg/g者激素使用率、用药时间长于<307.93μg/g者(P均<0.05)。结论粪便钙卫蛋白诊断儿童UC准确、无创、安全,有助于临床选择治疗药物及判断治疗效果. [ABSTRACT FROM AUTHOR]