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Objective To compare the curative effects between minimally invasive and standard direct approach of primary total hip arthroplasty (THA) in elderly patients. Methods One hundred and eighteen geratic patients with hip disease were divided into minimally invasive group (n=61) and standard group (n=57). All the patients were followed up from 15 months to 3 years. The length of incision, surgical duration, intraoperative blood loss, postoperative drainage, number of blood transfusion, hospitalization time and the Harris hip scores were compared between two groups. Results The length of incision, intraoperative blood loss, postoperative drainage, number of blood transfusion and hospitalization time were significantly lower in minimally invasive group than those in standard group, but the Harris hip scores were significantly higher 3 months after the operation in minimally invasive group than those in standard group (P < 0.05). First intention wound healing was found in all patients in two groups. The postoperative complications were significantly lower in minimally invasive group than those in standard group (3.28% vs 15.79%, P < 0.05). Conclusion Compared with standard incision of primary total hip arthroplasty , minimally invasive direct lateral approach has its advantages, including small surgical trauma, less hospitalization time, fewer complications, and which can help restore joint function quickly, making the curative effect satisfied in elderly patients. [ABSTRACT FROM AUTHOR]

目的探讨关节腔注人氨甲环酸与肾上腺素混合液对全膝关节置换术（TKA)后患者出血及凝血功能的影响。方法选择初次行单侧TKA患者64例，随机分为观察组和对照组，每组32例。两组常规进行TKA,术后留置引流管。观察组通过引流管向关节腔内注人含3.0g氨甲环酸、0.25mg肾上腺素的生理盐水50mL，对照组通过引流管向关节腔内注人含3.0g氨甲环酸的生理盐水50mL，两组均夹闭引流管2h。观察两组出血量（包括术中出血量、隐形出血量及总出血量）、术后引流量；两组术前及术后24h采用全自动生化分析仪检测血红蛋白(Hb)、红细胞压积（PCV)、凝血酶原时间（PT)、活化的部分凝血活酶时间（APTT)。结果两组术中出血量比较无统计学差异（P>0.05);观察组隐性出血量、总出血量及术后引流量均低于对照组（P<0.03或<0.0〗）。与术前比较，两组术后24hHb、PCV均降低，观察组术后24hPT升高（P均<0.05);对照组术后24hPT、APTT均较术前无明显变化(P均>0.05)。术后24h，观察组Hb、PCV均高于对照组（P均<0.01)，两组PT、APTT比较差异均无统计学意义(P均>0.05)。结论关节腔内局部注人氨甲环酸与肾上腺素混合液可减少TKA患者术后出血，且对其凝血功f旨影响较小。 [ABSTRACT FROM AUTHOR]