Search

Objective To observe the early postoperative analgesia effects of with four different modes for hernia repair in young children. Methods Eighty young children （aged 2-4 years old， ASAⅠ） scheduled for hernia repair were divided into TAP group （group T）， Caudal block group （group C）， incision local anesthetic drug infiltration group （group I） and intravenous control analgesia group （group P） according to the random number table， with 20 cases in each group. All young children underwent general anesthesia with laryngeal mask. Patients in group T were given the TAP of the incision with 0.25% ropivacaine 0.5 mL/kg under ultrasound-guided after the laryngeal mask was placed in. Patients in group C were given the caudal block with 0.25% ropivacaine 1 m L/kg after the laryngeal mask was placed in. Patients in group I were given the infiltration with 0.25% ropivacaine 0.5 mL/kg before the skin was seamed. Patients in group P were given the intravenous analgesia pump with tramadol 8 mg/(kg•d ) when the skin was seamed. The pain scores and HR， MAP numbers were recorded at 1， 2， 4， 6， 8， 12， 24 hours after operation. The duration of effective analgesia after operation， the incidence of lower motor block， the numbers of additional tramadol given， the times of first anal exhaust，the satisfaction of parents and the adverse effect after operation were recorded. Results There were no significant differences in pain scores among the four groups at the time points after operation. There were no significant differences in HR， MAP among the four groups before and after operation. Compared with group C， the duration of effective analgesia in group T， group I and group P were significantly longer （ < 0.05）， the incidence of lower motor block in group T， group I and group P were lower （ < 0.05）， the numbers of additional tramadol given in group T， group I and group P were less （ < 0.05）， and the times of first anal exhaust in group T， group I and group P were lower （ < 0.05） . The satisfaction of parents in group T， group C and group I were significantly higher than that in group P （ < 0.05） . There were 4 children with nausea and vomiting in group P. The incidence of nausea and vomiting in group T， group C and group I were significantly lower than that in group P （ < 0.05） . Conclusion Both ultrasound-guided TAP blockage and incision local anesthetic infusion blockade can provige a safe and effective analgesic effect in young children for hernia repair. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of parecoxib on the expression of GFAP in spinal dorsal horns and inflammatory responses in spinal cord of rats with neuropathic pain. Methods Fourty-two male SD rats， weighting 250-300 g，were randomly divided into 3 group （n = 14） : sham operation group （group S），group CCI and group P. The rats in group S had their sciatic nerve exposed without ligation．Rats in group CCI and group P underwent sciatic nerve ligation to induce neuropathic pain．The rats in group P were injected with parecoxib sodium 10 mg/(kg·d) through the tail vein for 3 days after operation. In group S and group CCI， the rats were injected with 0.9% NS through the tail vein at the same time. On 1 day before surgery and 4， 7， 14 days after surgery， the mechanical paw with drawal threshold （MWT） and thermal paw withdrawal latency（TWL） were measured. The rats were sacrificed at the 14st after surgery；L4-6 segments of the spinal cords were removed. The expression of glial fibrillary acidic protein （GFAP） was detected by immunohistochemistry. The levels of cyclooxygenase-2 （COX-2）， interleukin 1β （IL-1β） and tumor necrosis factor α （TNF-α） were detected by ELISA. Results Compared with group S， the MWT and TWL of group CCI and group P were significantly shortened （P < 0.05） on 4d， 7d and 14d after operation， and GFAP expression of spinal dorsal horn increased significantly at 14d after operation （P <0.05） . The levels of COX-2，IL-1β and TNF-αin the spinal cord increased （P < 0.05） . Compared with group CCI， the MWT and TWL of group P were significantly extended （P < 0.05） on 4d， 7d and 14d after operation， and GFAP expression of spinal dorsal horn increased significantly on 14d after operation （P < 0.05） . The levels of COX-2， IL-1β and TNF-αin the spinal cord decreased （P < 0.05） . Conclusion Parecoxib sodium can reduce the neuropathic pain in rats through inhibiting the spinal dorsal horn astrocyte activation， reducing COX-2 expression and reducing the inflammatory mediators of IL-1β， TNF-α in spinal cord. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect and the mechanism of parecoxib sodium pretreatment on permeability of blood-brain barrier in a rat model of focal cerebral ischemia-reperfusion injury．Methods Sixty male SD rats weighing 300g were randomly divided into 5 groups (n=12 each) : sham operation group (group S)； focal cerebral I/R group (group I/R)；parecoxib sodium 5 mg/kg pretreatment group (group L)；parecoxib sodium7.5mg/kg pretreatment group (group M)； parecoxib sodium 10 mg/kg pretreatment group (group H). Middle cerebral artery occlusion models were made by reforming Longa suture method in SD rats. Thirty minutes before ischemia， rats in group L， M and H were injected with 5 mg/kg、7.5 mg/kg and 10 mg/kg parecoxib sodium through the internal jugular vein. Group S and group I/R received equal volume of normal saline. ELISA technique was used to determine the content of S100β， TNF-α， IL-1β in Plasma. The changes of cerebral water content and the Evans Blue exudation from brain capillaries were observed. Results Pretreated with parecoxib sodium (5 mg/kg、7.5 mg/kg and 10 mg/kg)，the content of S100β，TNF-α，IL-1β in plasma were reduced. The cerebral water content and the EB in brain were reduced. Pretreated with parecoxib sodium 10 mg/kg， Longa scores were reduced. Conclusion Pretreatment with Parecoxib can protect blood-brain barrier against focal cerebral I/R injury by inhibition of the inflammatory reaction． [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and the mechanism of parecoxib pretreatment on focal cerebral ischemia-reperfusion injury in rats by measuring the content of TXA2，PGI2，IL-1β，TNF-α，PGE2 and TXA2/PGI2 in plasma. Methods Fourty-eight male SD rats were randomly divided into 4 groups （n＝12） : sham operation group （S）；model group （I/R）；parecoxib 5/10 mg/kg group （L， H） . Middle cerebral artery occlusion models were made by reforming Longa suture method in SD rats. Rats in L and H group were injected 5 mg/kg and 10 mg/kg parecoxib，respectively，through internal jugular vein 30 minutes before ischemia. Rats in S group and I/R group were given equal volume of normal saline. After ischemia for 90 mins and reperfusion for 24 hours， respectively， the neurologic deficit scores were measured， the pathological changes in CA1 region of hippocampus were detected by HE staining，radioimmunoassay technique was used to determine the content of TXA2，PGE2，TNF-α，IL-1β and TXA2/PGI2 in plasma. Results Pretreatment with parecoxib significantly decreased the content of TXA2，PGE2，TNF-α，IL-1β and TXA2/PGI2 in plasma， mitigated the injury in CA1 region of hippocampus and improved the nerve function of rats with focal cerebral ischemia-reperfusion injury. Conclusion Parecoxib can protect the brain from focal cerebral I/R injury by reducing the content of TXA2， PGE2， TNF-α， IL-1β and the ratio of TXA2/PGI2 in plasma of rats. [ABSTRACT FROM AUTHOR]