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利用信息技术手段对疫情管控措施进行评估，从而指导管控措施的实施，对疫情防控具有理论和现实意义。基于ACP方法和统计数据构建了人工城市计算实验平台，建立了针对具体疫情管控的社区、学校、工厂3类典型场所的人工社会模型，通过计算实验对新型冠状病毒肺炎疫情的管控措施进行评估。结果发现，检验检疫、自我防护管控措施只能够延缓疫情中感染人数峰值的到来，对降低总感染人数的效果不明显，只有经济代价巨大的隔离措施能够显著地抑制疫情的发展。隔离措施的良好效果表明，有效阻断“人-人”传播链是疫情控制的关键环节，因此建议综合采用检验检疫、大数据、人工智能等手段精准筛查病患及潜在感染者。

： 【目的】探讨不同剂量的植物化学物花色苷活性成分矢车菊素-3-葡萄糖苷（Cy-3-g）对ApoE -/- 小鼠 血小板来源的趋化因子及白细胞受体表达的抑制作用。【方法】75只 8周龄ApoE -/- 雄性小鼠随机分为5组，每 组15只，分别用添加200 mg/kg（低）、400 mg/kg（中）、800 mg/kg（高）三个剂量Cy-3-g的高脂饲料喂养，标准饲料 和高脂饲料分别为对照组和高脂组。实验周期为16周。每周记录小鼠体质量变化和摄食量，实验末期用试剂 盒测定血脂四项水平，分离小鼠颈动脉切片后做油红O染色，ELISA法测定血清中MIF，CXCL12及CCL2的水平， 流式细胞仪测定白细胞表面CXCR4、CXCR7的表达，同时进行尾部出血时间测定。【结果】与高脂组比较，中、高 剂量Cy-3-g降低了小鼠的血脂水平（P0.05）。【结论】在不造成出血风险的前提 下，花色苷Cy-3-g能显著抑制ApoE -/- 小鼠血清中趋化因子CXCL12、CCL2及白细胞上相应受体CXCR4、CXCR7 的水平。

深圳湾体育中心钢结构屋盖为超大跨度空间结构,由单层网壳、双层曲面网架及竖向支撑系统构成。单层网壳为复杂的空间曲面网格结构,采用箱形弯扭构件编织而成的四边形网格构成。首先基于弹性屈曲分析方法,深入地研究了结构的失稳模态和成因;其次,通过全过程跟踪结构的平衡路径,对结构非线性弹性和弹塑性稳定性能进行了研究,揭示了该类网壳结构的特殊失稳机理,提出针对该工程网壳结构的稳定设计准则;最后,采用有限元对网壳的局部稳定进行了分析,基于分析结果给出了网壳构件的计算长度系数取值。

【目的】选择幼龄小鼠模拟3~12岁儿童的过敏性气道炎症，探索膳食补充姜黄素对幼龄小鼠过敏性气道炎症 的防治作用。【方法】4周幼龄雌性BALB/c小鼠随机分为3组（每组n=8），分别是空白对照组，过敏性气道炎症模型组，姜 黄素干预组。在末次卵清白蛋白激发24 h后，观察各组小鼠的症状，测定肺泡灌洗液（BALF）中的炎症细胞数，全血细胞分 析白细胞亚型的数量，用HE染色观察肺部支气管周围炎症细胞浸润情况，用过碘酸-雪夫染色观察杯状细胞增生情况，酶 联免疫吸附法测定BALF中的细胞因子IL-4、IL-5、IL-13以及血浆中的总IgE水平，western blot技术检测肺组织磷酸化p38 丝裂原活化蛋白激酶（p-p38 MAPK）/p38 MAPK,，p-AKT/AKT蛋白表达情况。【结果】与过敏性气道炎症模型组相比，饲料 添加姜黄素的干预组可以明显改善幼鼠的反复抓挠鼻子、点头呼吸、体质量减轻等症状，外周血中嗜酸性粒细胞降低具有 统计学差异（P

在IP over WDM网络中,光层可以通过建立新的光路来为IP层提供带宽。如何利用光层有限的资源使网络服务提供商的利润最大化是流量疏导的一个重要目标。文章基于迭加网络模型,研究IP/MPLS over WDM网络的准入机制,设计算法在不影响整体效率的前提下为网络提供区分服务。

在迭加模型的IP over WDM网络中,文章作者进一步利用饱和割集算法来提取IP层的有效拓扑信息,利用该信息优化建立光路的方法,降低了整个网络的阻塞率。仿真结果显示,应用了双重饱和割集算法的网络比只用一种饱和割集算法的网络的阻塞率更低。

本文通过对多媒体技术需求的分析，结合Ｂ—ＩＳＤＮ的基本特性，研究多媒体技术在Ｂ—ＩＳＤＮ的实现。

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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In order to cultivate large diameter timber of Phoebe bournei, we conducted a 3-year soil loosening experiment on Phoebe bournei middle-aged stands. The main findings are as follows: loosening the surface soil, causing a decrease in soil bulk density, which increases year by year over time; an increase in soil capillary and non capillary pores, which decrease year by year; an increase in the natural moisture content and maximum water capacity of the soil, and over time, the natural moisture content and maximum water capacity decrease year by year; the growth of stands is accelerated, and the diameter at breast height, tree height, and volume growth are significantly higher than those of forests without loose soil, and the larger the soil loosening area, the better the growth. For cultivating large diameter timber of Phoebe bournei, it is recommended to do soil loosening operation every 3-5 years. [ABSTRACT FROM AUTHOR]

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Objective To investigate the risk factors of prognosis, recurrence and metastasis of breast cancer patients with non⁃pathologic complete response (non⁃pCR) after neoadjuvant chemotherapy. Methods The clinical characteristics of 500 patients with breast cancer diagnosed and treated with neoadjuvant chemotherapy, in the Breast Surgery Department of Guangxi Medical University Cancer Hospital from January 2016toDecember2020andtheFirstAffiliatedHospitalofHainanMedicalUniversityfrom January2020toDecember2022,were retrospectively analyzed. Compare the disease⁃free survival (DFS) and overall survival (OS) of pathologic complete response (pCR) and non⁃pCR patients, respectively. Cox regression analysis was used to screen independent risk factors for recurrence and metastasis of non⁃pCR patients after neoadjuvant chemotherapy. Results The median follow⁃up time was 38 months (range: 6-81 months) in the study cohort, and the median DFS and OS were not reached. The pCR rate after neoadjuvant chemotherapy was 19.4% (97/500). The 5⁃year DFS of pCR and non⁃pCR patients were 91.9 % and 81.2%, respectively (P=0.003), and their 5⁃year OS were 96.1% and 81.6%, respectively (P=0.007). A total of 71 patients experienced recurrence and metastasis after neoadjuvant chemotherapy, including 4 patients with pCR and 67 patients with non⁃pCR. Cox regression analysis showed that age > 35 years (HR=0.393, 95%CI: 0.220-0.701) was theprotective factor for recurrence and metastasis in non⁃pCR patients, while the histological grade 3 (HR=3.568, 95%CI: 2.050-6.210), high Ki⁃67 index (HR=2.742, 95%CI: 1.528-4.921), elevated postoperative Ki⁃67 index (HR=5.349, 95%CI: 2.470-11.586) and high pN stage (HR=6.716, 95%CI: 2.922-15.436) were independent risk factors for recurrence and metastasis in non⁃pCR patients. Conclusions Achieving pCR after neoadjuvant chemotherapy can improve the DFS and OS of the patients. Age≤35 years, histological grade 3, Ki⁃67>30%, elevated postoperative Ki⁃67 index and high pN stage are independent risk factors of recurrence and metastasis in non⁃pCR patients. [ABSTRACT FROM AUTHOR]

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This study aims to increase the fertilizer utilization rate for less fertilizer pollution in paddy fields. A side-deep fertilization device was developed to combine with the sliding-knife furrow opener and the pneumatic ejector for the liquid fertilizer atomizer using the side-deep fertilization and liquid fertilizer. The fertilizer was applied to the soil near the rice root zone. The structure of the inner cavity was designed for an air-liquid coaxial pneumatic ejector fertilizer atomizer. A full factorial soil bin test was conducted with the nozzle-throat distance, the mixer (throat) diameter, and air pressure. A systematic investigation was also made to explore the effects of each factor on the fertilizer discharge (liquid fertilizer mass flow rate) and air consumption (air flow). The findings indicate that the influencing factors of the liquid fertilizer mass flow rate were ranked in descending order of the mixer (throat) diameter, air pressure, and nozzle-throat distance. Similarly, the influencing factors of the air flow were ranked in descending order of the air pressure, nozzle-throat distance, and mixer (throat) diameter. The structural design was simulated and then optimized with the EDEM software. The Weighted Mark Method was used to comprehensively evaluate the simulation. The optimal performance was achieved in the sliding-knife furrow opener at various working rates when the sliding-cutting angle was 32.5˚ and the cutting-edge angle was 45˚. A soil bin test was implemented to verify the simulation. The measured and simulated traction resistance were 8.5, and 6.9 N, respectively, with a relative error of 18%, where the simulated soil disturbance area was 1965.6 cm², when the ditching depth of the sliding-knife furrow opener was 30 mm, and the forward speed was 1.2 m/s. Meanwhile, the measured and simulated traction resistance were 14.4 and 12.2 N, respectively, with a relative error of 15%, where the simulated soil disturbance area was 2137.2 cm² when the ditching depth was 50 mm and the forward velocity was 0.6m/s. When the ditching depth was 30mm and the forward speed was 1.2m/s, the standard deviation of fertilizer discharge was 0.2427g/s, the relative error to the maximum fertilizer discharge was 1.42%, and the relative error between the ditching depth and the fertilization depth was 4.4%, according to the soil bin performance test. When the ditching depth was 50 mm and the forward speed was 0.6 m/s, the standard deviation of fertilizer discharge was 0.479 6 g/s, the relative error to the maximum fertilizer discharge was 2.13%, and the relative error between the ditching depth and the fertilization depth was 2.1%. The finding can serve as promising guidance for the application of side-deep fertilization of liquid fertilizer in paddy fields. [ABSTRACT FROM AUTHOR]

The diagnosis and treatment of middle ear and temporal bone diseases through the external auditory canal by ear endoscopic surgery has been recognized by more and more physicians for its minimally invasive nature and better hearing reconstruction effect. In this paper, we discussed the clinical indications and future directions of ear endoscopic surgery, taking into account the latest literatures on endoscopic ear surgery research and the author’s experience of using endoscopic techniques to manage some rare cases of the ear. [ABSTRACT FROM AUTHOR]

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