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The mangrove ecosystem is a unique and important component of coastal ecosystems. However, microplastics, as a new type of environmental pollutant, enter the mangrove system through various pathways and have become a serious challenge for mangroves. This article analyzes the impact of microplastics on the mangrove ecosystem, including the distribution characteristics of microplastics in the mangrove ecosystem, the effects of microplastics on the mangrove ecosystem, the influencing factors of microplastic distribution in the mangrove ecosystem, and the fate of microplastics in the mangrove ecosystem. Finally, the research directions for microplastics in the mangrove ecosystem are discussed. Six studies were proposed to establish microplastic monitoring methods and detection standards, evaluate the ecological risks of microplastics in mangroves, establish measures for microplastic pollution control and management, predict microplastic models, explore remediation and removal strategies, and study the interaction between microplastics and carbon cycling in marine ecosystems. This study provides references for future research priorities and pollution control in the field of microplastics in mangroves. [ABSTRACT FROM AUTHOR]

An accurate detection can greatly contribute to the wheat ears in field environments. Traditional object detection models with horizontal bounding boxes cannot accurately detect the densely distributed wheat ears, particularly on the significant occlusion between ears and stalks. The high miss detection of wheat ears often occurs in the variation of illumination conditions, dense distribution, and small scales, due to the overlap of prediction bounding boxes. It is a high demand to orient the wheat ears with less noise and of large background for the high performance. In this study, an improved Oriented Region-based Convolution Neural Networks (R-CNN) model was proposed to detect and count rotated wheat ears. Firstly, the spatial pyramid pooling cross-stage partial networks (SPPCSPC) was added to the backbone network to generate the last layer of the output feature map. The sensing field was then enlarged to enhance the perceptual ability of the network; Secondly, the feature aggregation network and the efficient two convolutional block attention module (E2CBAM) hybrid attention mechanism module were introduced into the neck network to enrich the feature information in the feature map; Finally, the prediction bounding boxes were optimized using the flexible non-maximal inhibition algorithm soft-non maximum suppression (Soft-NMS), in order to optimize the predicted bounding boxes screening. The E2CBAM module was improved using the convolutional block attention module (CBAM) in the E2CA module, instead of the CAM channel attention module. The E2CA module was composed of two parallel ECA branch structures: the maximum and average pooling. Two adaptive convolution kernels were then obtained to sum. Finally, the channel assignment was weighted for the important channel information. The key feature was captured to improve the detection performance of the model. To verify the E2CBAM hybrid attention module, the path aggregation network (PANet) was introduced into the neck network to enrich the semantic and target location in the feature map. The detection accuracy of the model was then improved by 0.19 percentage points. Furthermore, the detection accuracy was improved by 0.16 and 0.31 percentage points, whereas, the number of parameters increased by 0.24 and 0.20 M. respectively, in the CBAM and E2CBAM hybrid attention mechanism module. The floating-point computation remained unchanged. Compared with the CBAM, the E2CBAM hybrid attention mechanism module improved the detection accuracy of the model by 0.15 percentage points, while reducing the number of parameters by 0.04 M with the unchanged computation. The experimental results show that the improved Oriented R-CNN model accurately represented the head direction of wheat ears, indicating better detection performance. The mean mAP of average accuracy was 2.02 percentage points higher than the original model, compared with the mainstream-oriented bounding boxes detection models. Moreover, the mAP values were improved by 4.99, 2.49, 3.94, 2.25, and 4.12 percentage points, respectively, compared with the mainstream rotating target detection models, Gliding vertex, R3det, Rotated Faster R-CNN, S2anet, and Rotated Retinanet. The Oriented RCNN was utilized to accurately represent the head direction of wheat ears. The background area was also reduced in the prediction bounding boxes. The model detection was more visually appealing. The finding can provide an effective way for the practical observation of the growth status of wheat ears and counting the number of ears. [ABSTRACT FROM AUTHOR]

Objective: To investigate the regulatory mechanism of miR-216a-5p on autophagy and radiosensitivity of gastric cancer cell and its regulatory effect on dual-specificity phosphatase 10 (DUSP10). Methods: SGC-7901 cells were irradiated with linear accelerator 6-MV X-ray at a dose rate of 0.8 Gy/min. The total dose is 8Gy. miR-216a-5p-mimic, NC-mimic, pcDNA-DUSP10 or pcDNA-NC were transfected into SGC-7901 cells with Lipofectamine 2000 reagent. After transfection, the cells were divided into miR-216a-5p-mimic group and NC-mimic group, and each group was divided into two subgroups, 0Gy and 8Gy. In the rescue experiment, the cells were divided into miR-216a-5p mimic+pcDNA DUSP10 group and miR-216a-5p mimic+pcDNA NC group. The mRNA levels of miR-216a-5p and DUSP10 were detected by qRT-PCR. Cell proliferation was detected by 5-ethynyl-2'-deoxyuridine (EdU) incorporation test and colony formation assay. The apoptosis was assessed by flow cytometry. The protein expressions of DUSP10, Bax, Bad, Bcl-2, LC3 and p62 were detected by Western blot. The expression of γH2AX was detected by immunofluorescence method to evaluate DNA double-strand break (DSB) in cells. The targeting relationship between miR-216a-5p and DUSP10 was detected by luciferase reporter gene. Autophagosomes were detected by GFP-mRFP-LC3. Results: Compared with the 8Gy NC-mimic group, the number of colonies, EdU positive rate and Bcl-2 protein expression level in the 8Gy miR-216a-5p-mimic group decreased, while the positive rate of γH2AX, the rate of apoptosis and the expression levels of Bax and Bad proteins increased (P<0.01). Compared with the 8Gy NC-mimic group, the number of autophagosomes and the expression level of LC3II protein in the 8Gy miR-216a-5p-mimic group decreased, while the expression level of p62 protein increased (P<0.001). After co-culture with miR-216a-5p-mimic, the relative luciferase activity of DUSP10-3'-UTR-WT was significantly reduced compared with the DUSP10-3'-UTR-MUT group (P<0.001). Compared with the NC-mimic group, the DUSP10 mRNA and protein expression levels in the miR-216a-5p-mimic group were lower (P<0.001). Compared with the miR-216a-5p mimic+pcDNA NC group, the number of colonies and autophagosomes in the miR-216a-5p mimic+pcDNA DUSP10 group increased, while the apoptosis rate was decreased (P<0.001). Conclusion: miR-216a-5p inhibits cell proliferation, increases radiation-induced apoptosis and inhibits radiation-induced autophagy by inhibiting DUSP10, thereby enhancing the radiosensitivity of gastric cancer cells. [ABSTRACT FROM AUTHOR]

Objectives: On January 8th 2022, an Ms 6.9 earthquake struck Menyuan, Qinghai Province, China. The epicenter is located in the middle section of Qilian-Haiyuan fault in the northeast margin of the Tibetan Plateau, which is a seismic gap. It is of great significance to study this earthquake for under-standing the tectonic deformation mechanism, strain release process and seismic hazards of the NE Tibetan Plateau.Methods: Differential synthetic aperture radar interferometry (D-InSAR) is used to obtain the coseismic deformation along the line of sight (LOS) of the Menyuan earthquake from Sentinel-1 satellite images. The co-registration of optically sensed images and correlation are used to obtain the EW coseismic deformation from the multi-temporal Sentinel-2 data. Based on the coseismic deformation field derived from InSAR interferograms, we invert the slip distribution. Results: The LOS deformation fields showed that the Menyuan earthquake caused a surface rupture of about 20 km long and the maximum LOS displacement was 0.75 m. The maximum EW displacement derived from optical images was 2.5 m. The slip distribution model showed that the Menyuan earthquake was dominated by a sinistral strike-slip. The coseismic slip is concentrated at a depth of 0 - 10 km. The maximum slip was 3.25 m at a depth of 4.89 km and the rake angle was 10.44°. The estimated total seismic moment is 1.07x1019 N.m, corresponding to a magnitude of Mw 6.6. Conclusions: According to the results from aftershock relocation, field investigation and tectonic background, we infer that the seismogenic fault is the Lenglongling fault and the eastern segment of Tuolaishan fault is also ruptured. The stress on the eastern segment of the Lenglongling fault and the western segment of the Tuolaishan fault is enhanced, implying that there is the possibility of strong earthquakes in this region in the future. [ABSTRACT FROM AUTHOR]

In this work, the corrosion process and corrosion mechanism of hot-dip gal vanized steel under different time periods were clarified through investigating the corrosion behavior of hot-dip gal vanized steel under neutral salt spray corrosion. The neutral salt spray accelerated test was simulated, and t he influence of different corrosion periods on the corrosion behavior of hot- dip galvanized steel were compared by weight loss method, SEM,XRD and Raman spectroscopy. The results showed that the corrosion rate of hot-dip galvanized steel gradually increased and finally became stable with the increase of corrosion period under 8 corrosion periods. In the process of corrosion, white and light yellow rust appeared on the surface at first. With the intensification of corrosion, maraud-red and black rust gradually appeared on the surface, and the corrosion layer gradually changed from relatively compact to fluffy, cracking and peeling. The main corrosion products are ZnCl2, Zn(OH)2, β-FeOOH, Fe3O4 and Fe2O3 • The 30-day corrosion process of hot-dip galvanized steel can be divided into three stages: the protection stage of galvanized layer, the damage stage of galvanized layer and the failure stage of galvanized layer. Among them,the corrosion rate is the highest in the damage stage of galvanized layer, and the corrosion products in this stage are mainly yellow rust (α-FeOOH) and reddish-brown rust (Fe203, Fe ( OH)3 ). The corrosion products are fluffy and cracked, providing a channel for the next step of corrosion. With the increase of corrosion period, the carbon steel substrate gradually exposed,at this time, the corrosion rate decreases and tends to be stable, the corrosion products are mainly red brown rust and black rust (Fe304),and the corrosion products are fluffy and easy to drop. [ABSTRACT FROM AUTHOR]

Due to the disadvantage that model reference adaptive observer (MARS) is sensitive to parameter variations of PMSM and external disturbances, this paper developed a soft-switched sliding mode model reference adaptive observer for PMSM sensorless control. The observer combined the sliding mode control with MRAS. And constructing a variable sinusoidal saturation function was to enhance the robustness of the system and effectively reduce the chattering phenomenon. At the same time, it introduced the sigmoid function to improve the stability of the sliding mode soft switching speed controller. The simulation results show that the mode model reference adaptive control based on soft-switching sliding can achieve convergence faster, reduce the chattering phenomenon and improve the tracking performance. [ABSTRACT FROM AUTHOR]

AC withstand voltage test is a routine test for on-site handover of high-voltage equipment． The conventional withstand voltage test device system is composed of power supply，transformer，reactor，and capacitor． During the test，the loading and unloading process of the equipment is difficult，the wiring is complicated，and the time is long． In order to solve the problem of low efficiency of field test，a 750 kV AC voltage withstand test vehicle is developed by refitting the car structure and integrating the excitation transformer，capacitance voltage divider and resonant reactor into SF6 integrated metal tank． The test vehicle has strong maneuverability，and the whole test system in the vehicle can be automatically deployed without secondary assembly and secondary wiring，which improves the efficiency of field AC voltage withstand test． [ABSTRACT FROM AUTHOR]

Galectin-9（ Gal-9） is a member of the galectin family that can specifically recognize and bind to galactosides. Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases. This article reviews the immunomodulatory functions of Gal-9 and its role in different liver diseases. Studies have shown that Gal-9 has important biological functions in different liver diseases through multiple pathways. Research on the specific immunomodulatory mechanisms and functions of Gal-9 may help to discover the therapeutic role of Gal-9 in liver diseases. [ABSTRACT FROM AUTHOR]

In 2020-2021, the effects of intercropping of different maize genotypes on multiple disease resistance and yield were studied using the main maize in Henan Province as materials, aiming at providing theoretical basis for farmers in Henan Province. Dedan 5. Denghai 605, Zhongkeyu 505 and Yufeng 303 were used as materials to study the effects of intercropping on population yield, as well as the incidence of stem rot, leaf spot, ear rot and southern rust. Results showed that intercropping different genotypes of maize could improve the resistance of the composite population to stem rot, small leaf spot, ear rot and southern rust compared to monocropping. The yield of intercropping was significantly higher than that of monocropping each variety, with significant yield increase benefits. Intercropping between Dedan 5 and Denghai 605 could improve the yield of the composite population and ensure the stability of yield. [ABSTRACT FROM AUTHOR]

[Objective] Exploring the propagation characteristics and response probability of meteorological hydrological drought is conducive to providing scientific reference for hydrological drought early warning. [Methods] Based on the meteorological and hydrological data of 35 meteorological stations and Wangjiaba and Xixian hydrologic stations in the upper reaches of the Huai River from 1980 to 2013, the basin above Wangjiaba was divided into two sub basins: Xixian (XX) and Xixian Wangjiaba interval (WJB). The Standardized Precipitation Evapotranspiration Index (SPEI) and Standardized Runoff Index (SRI) of each region were calculated respectively, and the meteorological hydrological drought response time of each region was calculated by using the correlation coefficient method. The hydrological drought events were matched to obtain the meteorological hydrological drought propagation characteristics of different regions. Further, combined with Copula joint distribution function and Bayesian network, the meteorological hydrological drought response probability model of the upper reaches of the Huai River was constructed to calculate the meteorological hydrological drought response probability under different return periods. [Results] (1) The response time of meteorological hydrological drought in WJB and XX was 7 months and 5 months, respectively, the average drought propagation duration in the two regions was about 1 month, and the average drought relief duration was about 2 months. (2) The durations and intensities of meteorological drought in WJB and XX were generally less than the corresponding hydrological drought characteristic values, and the sensitivity of hydrological drought in WJB to meteorological drought was lower than XX. (3) The meteorological hydrological drought response probabilities of WJB and XX were in direct proportion to the duration, intensity and intensity of meteorological drought. WJB was more prone to hydrological drought events with longer drought duration, while XX was more prone to hydrological drought events with greater drought intensity and intensity. (4) When meteorological drought spreaded to hydrological drought with the same return period, the response probability of meteorological hydrological drought decreased with the increase of return period, and the response probability of XX meteorological hydrological drought was greater than WJB. [Conclusion] There were differences in the meteorological and hydrological drought propagation characteristics and response probability between XX and WJB. Therefore, the hydrological drought early warning research should be strengthened based on the differences. [ABSTRACT FROM AUTHOR]

Bavachinin is a dihydroflavone isolated from dried ripe fruits of Psoralea corylifolia L.，which has various pharmacological activities, such as anti-tumor, anti-virus, anti-diabetes, anti-inflammatory and neuroprotective, and good potential in clinical applications. With the increasing concern about the safety of P. corylifolia applications in clinical, the bavachinin has been found to be one of the main components causing liver injury. In this paper, the pharmacological activities and hepatotoxicity of bavachinin in the recent 20 years were reviewed, in order to provide reference for the further study and clinical application. [ABSTRACT FROM AUTHOR]

Objective · To investigate whether vitamin E could reverse the disruptive effects of bisphenol A (BPA) on steroidogenesis and to explore the optimal vitamin E concentration. Methods · Rat primary granulosa cells were extracted and exposed to BPA (0, 0.01, 0.1,1,10,100 μmol/L). After 48 h of incubation, culture medium was collected and estradiol (E2) and progesterone (P4) were measured using ELISA kits. Then, granulosa cells were incubated with 5 μmol/L(average concentration in follicular fluid) or 25 μmol/L (high concentration in follicular fluid) vitamin E (α-tocopherol) or vitamin E (5 μmol/L or 25 μmol/L) plus BPA (10 μmol/L or 100 μmol/L) for 48 h, E2 and P4 were measured. Results · BPA at 10 μmol/L and 100 μmol/L suppressed E2 and P4 production in a dose-dependent manner (P<0.05). Vitamin E at 25 μmol/L significantly increased E2 and P4 levels by (44.89±15.18) % and (43.33±8.82) % (P<0.05), respectively. Coincubation of the granulosa cells with BPA and vitamin E (5 μmol/L or 25 μmol/L) restored the productions of E2 and P4, which were not significantly different from the control group (P>0.05). Conclusion · Vitamin E (5 μmol/L/25 μmol/L) could reverse BPA-induced reduction in steroid hormone production in rat ovary granulosa cells, and the antagonistic effect of 25 μmol/L vitamin E was more obvious than that of 5 μmol/L vitamin E. [ABSTRACT FROM AUTHOR]

Objective · To investigate the effects of maternal vitamin D deficiency and supplementation on the immunomodulatory function of Th1/Th2 in offspring rats. Methods · Forty-eight female SD (8-week-old) rats were randomly assigned to three groups, i.e control group (C group, n=16), vitamin D deficiency group (VDD group, n=16), and vitamin D supplementation group (VDS group, n=16). C group was fed a normal diet and VDD and VDS groups were fed a vitamin D deficiency diet. After four weeks, females and males were housed in a 2∶1 ratio. After gestation, C group and VDS group were fed a normal diet and VDD group was still fed a vitamin D deficiency diet. The vitamin D level in female rats was measured using LC-MS/MS at gestational day 10 (second trimester). The vitamin D level, the ratio of Th1/Th2, and expressions of serum IFN-γ and IL-4 in offspring were measured using LC-MS/MS, flow cytometry, and ELISA 4 weeks after birth, respectively. Results · For C group, VDD group, and VDS group, the 25(OH)D levels in female rats were (23.23±2.08), (5.52±2.36), and (11.35±1.84) ng/mL, respectively, while the 25(OH)D levels in offspring were (7.15±1.30), (0.93±0.22), and (6.82±1.37) ng/mL, respectively. The 25(OH)D levels in female rats and their offspring of VDD group were significantly lower than those of C group and VDS group (P<0.05). The Th1/Th2 ratios in offspring of C group, VDD group, and VDS group were 0.90±0.35, 0.24±0.08, and 0.94±0.26, respectively. The Th1/Th2 ratio in VDD group was significantly polarized toward Th2 and polarization of Th2 in VDS group was remarkably improved compared with C group. The IFN-γ levels in C group, VDD group, and VDS group were (18.72±5.66), (8.27±3.86), and (19.31±5.68) pg/ml, and the IL-4 levels were (3.49±0.52), (4.14±0.55), and (3.52±0.52) pg/ml. The IFN-γ level significantly decreased and the IL-4 level significantly increased in VDD group compared with C group and VDS group (P<0.05). Conclusion · Vitamin D deficiency in pregnant rats caused the imbalance of Th1/Th2 (Th2 polarization) and IFN-γ/IL-4 (drifting toward IL-4) in offspring. Vitamin D supplementation significantly improved the imbalance of Th1/Th2 and IFN-γ/IL-4 in offspring. [ABSTRACT FROM AUTHOR]

This paper explores the critiques of the Taiji Tushuo《太極圖說》， one of the most important classics of Shushigaku 朱子學 in the history of Japanese ConfUcianism， that were advanced by Ito Jinsai 伊藤仁齋 and Ito Togai 伊藤東涯. Jinsai and Togai were famous for their anti-Shushigaku thought. Although there are some misunderstandings present in their critiques of the Taiji Tushuo and Zhu Xi 朱熹， it is argued here that their interpretations still have value because they shed light on a different perspective regarding the Yijing and the Taiji Tushuo. [ABSTRACT FROM AUTHOR]

Objectives: Chronic kidney disease (CKD) has been shown to cause osteoporosis because of renal bone disease, thus CKD patients are at higher risk for total hip replacement (THR) than patients without CKD; however, there are few studies which have determined whether or not the outcomes are positive or negative when CKD patients undergo THR. Therefore, the aim of this study was to explore the influence of CKD on THR patient outcomes. Methods: The study adopted a retrospective cohort study design, and the subjects were adult THR patients. Data were derived from the National Health Insurance Research Database between 2009 and 2011. According to the patients who did or did not have CKD the year prior to the THR, the patients were divided into two groups (CKD and non-CKD groups), and a propensity score was used to match subjects. Cox proportional hazards regression was used to analyze the outcomes. Results: In the CKD group, the 90-day post-operative infection, readmission, and death rates were higher than the non- CKD group. The 90-day post-operative infection (AHR=1.8), readmission (AHR=1.9), and death risk (AHR=3.5) in the CKD group were also higher than the non-CKD group. Conclusions: CKD patients have higher risks of 90-day post-operative infections, re-admission, and death than people without CKD after THR. Health authorities and medical institutions should strengthen the care for patients with CKD receiving THR to reduce the likelihood of adverse outcomes. [ABSTRACT FROM AUTHOR]

人体蠕形螨是一类永久性寄生螨,寄生于人的毛囊和皮脂腺内,虫体的机械刺激和其分泌物的 化学刺激可引起皮肤组织的炎性反应,导致毛囊炎、痤疮、酒糟鼻、眼睑缘炎等疾病的发生,从而对患者尤其是 青少年患者的外貌和心理造成很大影响。该文就人体蠕形螨的生活史、感染和致病机制、感染情况、人体蠕形 螨病的预防及治疗的研究现状进行综述。 [ABSTRACT FROM AUTHOR]

To investigate the relationship between the blastomere integrity and reproductive outcome, the resumption of cleavage and reproductive outcome respectively, from the freeze-thawed embryo derived from testicular biopsy or testicular microsperm extraction. A retrospective analysis was performed of data from 658 patients who received frozen-thawed embryos transfer (FET). According to sperm source, these embryos were divided into 445 cycles of ejaculated sperm group (ICSI group) and 213 cycles of testicular biopsy or microdissection testicular sperm extraction (TESA group). When two embryos thawed, ICSI group was divided into three groups (A, B, C group) based on the number of integral embryos (0, 1, 2). Similarly, TESA group was also divided into D, E and F groups. ICSI group was divided into three groups (G, H, I group) according to the number of resumption of cleavages (0, 1, 2) after two embryo frozen-thawed. Similarly, TESA was also divided into J, K and L groups. The reproductive outcome were compared between the groups, respectively. ① The integrity rate, cleavage rate of embryos cultured in vitro within 18-20 h after thawing, implantation rate, clinical pregnancy rate, live birth rate, gestational age and birth weight were not significant difference between ICSI and TESA group (P>0.05). However, the early miscarriage rate in ICSI group was significantly higher than TESA group. ② There was no statistical difference in reproductive outcome mentioned above between group B and group C (P>0.05). However, the implantation rate, clinical pregnancy rate and live birth rate were significantly higher than group A (P<0.05). The reproductive outcome showed no statistical difference between three subgroups of TESA (P>0.05). There was no significant difference between ICSI and TESA groups (P>0.05). ③ The implantation rate, clinical pregnancy rate and ongoing pregnancy rate of group I were significantly higher than group H (P<0.05), and both groups were significantly higher than group G (P<0.05). The live birth rate was significantly higher in group I compared with group G and H (P<0.05). The implantation rate, clinical pregnancy rate, ongoing pregnancy rate and live birth rate of L group were significantly higher than group J (P<0.05). There was no significant difference between ICSI and TESA groups (P>0.05). Although the sperm quality of testicular biopsy or microdissection testicular sperm extraction was poor, the FET outcomes were not different from those embryos derived from ejaculated sperm once effective embryos were formed. Transferring at least one integral embryo had better reproductive outcomes than transferring two blastomere damaged embryos. Similarly, better reproductive outcomes was observed in transferring at least one cleavage embryo than two non-cleavage embryos. If there was neither integral embryo after thawing nor cleavage after overnight culture, it should be carefully considered whether to cancel the FET [ABSTRACT FROM AUTHOR]

Aiming at the problem of operational effectiveness evaluation of anti-tank minefield, a method of operational effectiveness evaluation of anti-tank minefield based on Harris Hawks Optimization(HHO) optimized Monte Carlo neural network(MCNN) is proposed. Firstly, the basic principles and algorithm flow of IHHO algorithm and Monte Carlo neural network are introduced. Then the main influencing factors of the effectiveness evaluation of anti-tank minefield are analyzed, and the index system of the effectiveness evaluation of anti-tank minefield is summarized. Finally, the IHHO-MCNN neural network evaluation model is constructed. The simulation results show that the model can effectively evaluate the effectiveness of anti-tank minefield. [ABSTRACT FROM AUTHOR]

Objectives: Township-level physician-to-population and hospital bed-to-population ratios have been widely adopted as indicators of health care accessibility in Taiwan; however, these indicators cannot reflect actual healthcare-seeking behaviors of patients. Therefore, the aims of this study were to establish actual patient flow for seeking healthcare and to clarify the factors influencing preferences for seeking healthcare. Methods: We estimated the residence and collected the locations of healthcare visits for each patient from the nationwide Longitudinal Health Insurance Database in 2010 to establish an origin-destination matrix. The patient flow among townships could be conducted from the matrix. The weighted travel distance of healthcare visits was developed as a new indicator of accessibility. The gravity model was then used to analyze the patient flow and assess the influences of travel distance and healthcare resources. Results: Using the weighted travel distance, eastern Taiwan and the coastal areas of Yunlin and Chiayi were identified as the poorest accessibility for healthcare resources. The results of the gravity model showed that travel distance was the major factor correlated negatively with the volumes of outpatient and inpatient/emergency flow; however, the abundance of healthcare resources positively influenced the preference of inpatient/emergency patients from their residence to neighborhood regions for seeking healthcare. Conclusions: The weighted travel distance could properly reflect the access of healthcare. We conclude that travel distance is the major factor which influences patient flow for seeking healthcare. In contrast, people tend to choose the healthcare facilities with abundant resources for seeking inpatient/emergency healthcare. [ABSTRACT FROM AUTHOR]

Objective: To study the effects of triclosan on progesterone (P4) Production in cultured rat granulosa cells. Methods: Primary cultured rat granulosa cells were prepared. Granulosa cells were treated with increasing concentrations of triclosan (0,0.01, 0.1and 1 μM) for 24 h. Cellular viability was assessed by the MTT assay method. Concentrations of P4 in the medium were measured by enzyme immunoassay (ELISA). Expression of steroidogenic acute regulatory protein (St AR), P450 side chain cleavage enzyme (P450scc)and 3β-hydroxysteroid dehydrogenase (3β-HSD) were monitored by quantative real time PCR (q RT-PCR) and western blot analysis. Results: Triclosan doses used in this study had no significant effect on granulosa cells viability (P>0.05). 0.1 and 1μM triclosan decreased P4 production in a dose-dependent manner (P>0.05). 0.1 and 1 μM triclosan significantly increased St AR m RNA expression level and reduced P450 scc m RNA expression level (P<0.05). 1 μM triclosan reduced St AR and P450 scc protein expression level (P<0.05). But triclosan had no significant effects on 3β-HSD both on m RNA and protein expression level (P>0.05) .Conclusions: Triclosan can inhibit the production of P4 in primary cultured rat granulosa cells. The disruption effects of triclosan on key steroidogenic molecules may be one of the mechanisms. [ABSTRACT FROM AUTHOR]

Digital twin technology has the characteristic of virtual real fusion. The digital twin for intelligent factories can make the production process more transparent, and the production can be effectively guided with the real-time data in the workshop. In order to realize the visual control of production process based on the digital twin, a method of digital twin modeling for intelligent factories oriented to the production process is proposed. First, the framework of the digital twin system for intelligent factories is constructed. Second, the key technologies are elaborated, including the method of 3D geometric modeling based on the point cloud fitting, the method of object linking and embedding for process control unified architecture (OPC UA) information modeling for data interaction, multi-source heterogeneous data integration and fast matching of virtual-real mapping data. Finally, the digital twin system for an engine manufacturing workshop is realized. This demonstrates the correctness and effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

BACKGROUND: The structure of nanofibers prepared by electrospinning technology is similar to that of natural tendon tissue and extracellular matrix, and has the inherent characteristics of nanofibers. OBJECTIVE: To review the structure of various electrospinning scaffolds and their application in tendon and rotator cuff tissue engineering systematically. METHODS: PubMed, CNKI, Wanfang, and Web of Science databases were searched for relevant articles published from 2000 to 2020 with the search terms of “electrospun, tendon, rotator cuff, tissue engineering” in both English and Chinese. Totally 69 articles were finally included for analysis. RESULTS AND CONCLUSION: There are various strategies in manufacturing electrospun scaffolds. Scaffolds differ from material selection, fiber composition, modification and drug loading and many other aspects. Natural and synthetic materials both have their own advantages. Hybrid electrospinning of more than two kinds of materials can produce unique properties. Although non-aligned fibers have better tensile length, aligned fibers have advantages in elastic modulus, fracture strength and biocompatibility. Nanofibrous scaffolds can also be used in drug release, and it may have a modified characteristic and improve rotator cuff and tendon healing. [ABSTRACT FROM AUTHOR]

In order to solve the problem of low channel utilization and throughput because of burstiness on high-priority service accessing the satellite channel on account of long-range combat aircraft transmitting different priority service when it accessed satellite channel, the paper proposed a dynamic channel access strategy supporting service with priority for satellite communication network. The access strategy constructed the spectrum pool to share channel through introducing the cognitive radio technology. It set the high-priority service accessing channel freely, meanwhile, it ensured low priority business access the channel successfully through reserving spare channel. When there was some service not accessing channel, the service used the queuing model for access. The simulation results show that this strategy can effectively guarantee the successful ratio of high-priority service accessing channel, meanwhile, it effectively reduces the access delay. When the access strategy is applied, it can effectively reduce the impact of burstiness on high-priority service accessing the satellite channel, which leads to improving the comprehensive utilization rate of the satellite channel, reducing the access delay of low-priority service and guaranteeing the throughput on low-priority service accessing the satellite network. [ABSTRACT FROM AUTHOR]

To investigate the subsequent development of drop impact in impinging stream, the theoretical model was established to correctly reflect the droplet collision and subsequent development. The proposed model was used to simulate the coalescence or the secondary atomization by droplet collision in eoaxially opposed two gas-liquid impinging stream. The particle size distribution of droplets between two nozzles was theoretically investigated, and the effects of size, velocity, viscosity and impact angle on droplet size distribution were analyzed. The simulation results show that the smaller the droplet size is, the greater the probability7 of collision coalescence is. The greater the viscosity is, the greater the probability of collision coalescence is. Droplets occur coalescence when the velocities are small. With the increasing of velocity, the probability of secondary atomization is increased. Under the same conditions, when droplets occur oblique impact, the probability of secondary atomization is larger than that for direct impact. [ABSTRACT FROM AUTHOR]