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新型位移放大型扭转阻尼器（displacement-amplified torsional damper，DATD）通过铅芯和橡胶的剪切滞回变形实现复合耗能，进一步分析了DATD的工作原理和耗能性能，并对安装有该阻尼器的框架梁柱节点的抗震性能进行了研究。采用ABAQUS软件分别建立DATD、普通现浇节点与安装有DATD的节点的有限元模型，对比DATD有限元分析结果与前期试验结果，二者滞回曲线吻合良好，从而验证该数值模拟方法的有效性。进一步地，对比普通节点与DATD节点在循环荷载作用下的耗能性能，分析DATD对梁柱节点抗震性能的影响。研究结果表明，DATD节点滞回曲线饱满，耗能能力优越，能够延缓节点开裂，保护梁柱节点。

BACKGROUND: Lijin manipulation can promote skeletal muscle repair and treat skeletal muscle injury. However, the formation of fibrosis and scar tissue hyperplasia are closely related to the quality of skeletal muscle repair. To study the regulatory effect of Lijin manipulation on the formation of fibrosis and scar tissue hyperplasia is helpful to explain the related mechanism of Lijin manipulation to improve the repair quality of skeletal muscle injury. OBJECTIVE: To explore the mechanism of Lijin manipulation to improve the repair quality of skeletal muscle injury in rabbits, thereby providing a scientific basis for clinical treatment. METHODS: Forty-five healthy adult Japanese large-ear white rabbits were randomly divided into blank group, model group and Lijin group, with 15 rats in each group. Gastrocnemius strike modeling was performed in both model group and Lijin group. The Lijin group began to intervene with tendon manipulation on the 3rd day after modeling, once a day, and 15 minutes at a time. Five animals in each group were killed on the 7th, 14th and 21st days after modeling. The morphology and inflammatory cell count of gastrocnemius were observed by hematoxylin-eosin staining, the collagen fiber amount was observed by Masson staining, the expression of interleukin-6 and interleukin-10 in gastrocnemius was detected by ELISA. The protein and mRNA expressions of paired cassette gene 7, myogenic differentiation factor, myoblastogenin, alpha-actin, transforming growth factor beta 1, and type I collagen were detected by western blot and RT-PCR, respectively, and the expression of type I collagen protein was detected by immunohistochemistry. RESULTS AND CONCLUSION: Hematoxylin-eosin staining and Masson staining showed that compared with the model group, inflammatory cell infiltration and collagen fiber content decreased in the Lijin group (P < 0.01), and the muscle fibers gradually healed. ELISA results showed that compared with the model group, the expression of interleukin-6 in the Lijin group continued to decrease (P < 0.05), and the expression of interleukin-10 increased on the 7th day after modeling (P < 0.05) and then showed a decreasing trend (P < 0.05). Western blot and RT-PCR results showed that compared with the model group, the protein and mRNA expressions of paired cassette gene 7, myogenic differentiation factor, myoblastogenin in the Lijin group were significantly increased on the 14th day after modeling (P < 0.05), but decreased on the 21st day (P < 0.05); the protein and mRNA expressions of alpha-actin, transforming growth factor beta 1, and type I collagen in the Lijin group were significantly decreased compared with those in the model group (P < 0.05). Immunohistochemical results showed that the expression of type I collagen in the Lijin group was significantly lower than that in the model group (P < 0.05). To conclude, Lijin manipulation could improve the repair quality of skeletal muscle injury by inhibiting inflammation, promoting the proliferation and differentiation of muscle satellite cells, and reducing fibrosis. [ABSTRACT FROM AUTHOR]

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Objective: To discover novel FLT3 inhibitors from the ChEMBL database by using virtual screening technology, and provide a theoretical foundation for the development of small molecule inhibitors targeting FLT3. Methods: Approximately 2.4 million small molecules from the ChEMBL database were selected as the dataset. FLT3 protein was chosen as the target, and virtual screening was conducted via molecular docking. The binding affinity and stability of target compounds with FLT3 protein were investigated by using 200 ns of molecular dynamics simulation. Results: Five novel potential FLT3 inhibitors (ChEMBL ID: 5186572, 4845881, 2151842, 3642822, 3916042) not previously reported in the literature were successfully discovered by virtual screening. The docking scores (-10.93 to -12.58) and binding free energies (-82.06 to -88.49 kcal/mol) of these compounds were superior to the reference compound Gilteritinib (-8.73 and -65.38 kcal/mol). The results of molecular dynamics simulation have demonstrated a strong binding affinity of the target compounds with FLT3 protein, leading to the formation of stable complexes. Conclusion: Five novel potential FLT3 inhibitors with potential anti-tumor activity not previously reported were discovered by virtual screening technology. These findings provide an important theoretical foundation for the development of next-generation FLT3 inhibitors. [ABSTRACT FROM AUTHOR]

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目的 探讨六西格玛联合目标管理在提高病原学送检率的应用及效果评价, 为抗菌药物管理 和多重耐药菌防控提供依据. 方法 选取使用治疗性抗菌药物的住院患者为研究对象, 2022年1-6月的患者 为干预前组, 2022年7-12月实施六西格玛联合目标管理措施的患者为干预组, 2023年1-12月的患者为干 预后组; 对比分析干预前后抗菌药物治疗前病原学送检率、指向性病原学标本送检率及多重耐药菌医院内感染 发生率的变化. 结果 实施六西格玛联合目标管理后, 不同级别抗菌药物治疗前前病原学送检率、医院内感染 诊断相关病原学送检率、指向性病原学送检率均显著提高, 且与干预前及干预组比较, 差异有统计学意义(P< 0.001); 重点抗菌药物联用治疗前病原学送检率干预前组(87.92%)、干预组(88.76%)及干预后组(90.97%) 比较, 差异无统 计 学 意 义 (P >0.05); 干 预 前 组、干 预 组 及 干 预 后 组 多 重 耐 药 菌 检 出 率 分 别 为 10.18%、 11.35%、11.97%, 3组间差异无统计学意义(P>0.05); 干预后组多重耐药菌发现率为0.18%, 明显低于干预 前的0.25%及干预组的0.31%, 差异有统计学意义(P<0.001). 结论 应用六西格玛联合目标管理可以有效 提高住院患者抗菌药物治疗前病原学送检率, 降低多重耐药菌医院内感染发生率, 但医院内感染诊断相关病原 学及重点抗菌药物联用治疗前病原学送检率仍未达到标准, 需要在下一阶段进一步干预. [ABSTRACT FROM AUTHOR]

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The microbiological quality of laboratory animals is crucial for the validity and reproducibility of scientific research data, as well as human health and animal welfare. Currently, individual ventilation cages (IVC) have become the mainstream feeding system for rodent laboratory animals. The most commonly used pathogen monitoring method for this feeding system is soiled bedding sentinels (SBS). This method monitors the microbial carrying status of mouse colony through indirect contact and delayed feedback. It can effectively monitor pathogens transmitted via the fecal-oral route, such as mouse hepatitis virus and reovirus. However, this method has difficulty detecting pathogens mainly transmitted through aerosols or direct contact, such as Sendai virus and Pasteurella pneumotropica. The exhaust air dust (EAD)- PCR monitoring method involves swab sampling in the IVC exhaust ducts to monitor the corresponding racks of the ducts; swab sampling before the prefiltration of the host to monitor the entire IVC rack; and EAD collection device sampling to monitor all racks connected to the same host. Different IVC manufacturers have developed corresponding EAD collection devices for their respective IVC systems, making operations convenient and standardization easy. Compared with the SBS method, the EAD-PCR method significantly improves detection rate and timeliness, with the fastest detection possible after one week of exposure. It can serve as a supplement or replacement for the SBS method. Currently, increasing evidence supports that EAD-PCR testing is a more reliable, sensitive, and cost-effective monitoring method, and is more beneficial to animal welfare. This article reviews the application progress of these two methods for monitoring pathogens, analyzes the existing limitations of the EAD-PCR method, and proposes solutions based on its implementation in our laboratory and examination units. The EAD-PCR method helps reduce the number of live sentinel animals used in pathogen monitoring, in order to better maintain the "3Rs" principle of laboratory animal welfare. [ABSTRACT FROM AUTHOR]

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Objective：Transcriptome sequencing analysis was used to study the differentially expressed genes （DEGs） and key signaling pathways of the posterior cervical muscles of rabbits in a model of chronic static injury. Method：The chronic static load injury model of posterior cervical muscle in rabbits was replicated by longterm repeated flexion of the neck of rabbits. DEGs were screened by transcriptome sequencing and analyzed for GO function enrichment and KEGG pathway enrichment. Build a PPI network and filter out the top 10 DEGs. Result：Compared with the blank group，there were 310 DEGs，of which 193 were upward and 117 were downward in the model group. GO analysis showed that the different genes in the model group were mainly involved in related functions such as inflammation and immune response regulation. KEGG analysis showed that phagosomes were active in Fcγ-R-mediated phagocytosis and NF-κB. The PPI network identified 10 hub genes，among which TLR4，CTSS，ITGB2，TYROBP，CD74，LAPTM5 and other expressions were up-regulated， and only PPARG expression was down-regulated. Conclusion：The pathological changes of chronic static injury of cervical muscles involve plenty of basic biological processes，and the inflammatory response and the disorder of immune microenvironment play an important role in it. Transcriptional activation of differential genes closely related to inflammatory responses and pathway molecules such as NF-κB signaling pathway，phagosomes，and Fcγ-R-mediated phagocytosis may be its main molecular mechanisms. [ABSTRACT FROM AUTHOR]

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