47,063 results on '"A. Cabello"'
Search Results
2. Endocarditis protésicas: evolución en los últimos años en un hospital terciario de madrid
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M. Bernal Palacios, M. Morante Ruiz, A. Cabello Úbeda, A. Pello Lázaro, G. Aldámiz Echevarría, R. Hernández Estefanía, M.Á. Navas Lobato, L. Landaeta Kancev, B. Álvarez Álvarez, and L. Varela Barca
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Medicine ,Surgery ,RD1-811 - Published
- 2024
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3. EXPERIENCIA CON EL USO DE DALBAVANCINA EN ENDOCARDITIS INFECCIOSA EN UN HOSPITAL TERCIARIO
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A. Arapiles Muñoz, M. Morante Ruiz, A. Cabello Úbeda, B. Álvarez Álvarez, L. Prieto Pérez, G. Toledano Mayoral, R. Fernández Roblas, A. Pello Lázaro, G. Aldámiz-Echevarría del Castillo, V. Hortigüela Martín, and M. Górgolas Hernández-Mora
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Medicine ,Surgery ,RD1-811 - Published
- 2023
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4. EXPERIENCIA EN EL MANEJO DE LA ENDOCARDITIS INFECCIOSA ANTES Y DESPUÉS DE IMPLANTAR UN EQUIPO MULTIDISCIPLINAR
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M. Morante, A. Cabello, A. Pello, R. Hernández, R. Fernández-Roblas, G. Aldamiz-Echevarría, M.Á. Navas, V. Hortigüela, M. Tomás, and L. Varela
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Medicine ,Surgery ,RD1-811 - Published
- 2023
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5. Optimal conversion of Kochen-Specker sets into bipartite perfect quantum strategies
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Trandafir, Stefan and Cabello, Adán
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Quantum Physics ,81P13 - Abstract
Bipartite perfect quantum strategies (BPQSs) allow two players isolated from each other to win every trial of a nonlocal game. BPQSs have crucial roles in recent developments in quantum information and quantum computation. However, only few BPQSs with a small number of inputs are known and only one of them has been experimentally tested. It has recently been shown that every BPQS has an associated Kochen-Specker (KS) set. Here, we first prove that any BPQS of minimum input cardinality that can be obtained from a generalized KS set can also be obtained from a KS set of pure states. Then, we address the problem of finding BPQSs of small input cardinality starting from KS sets. We introduce an algorithm that identifies the BPQS with the minimum number of settings for any given KS set. We apply it to many well-known KS sets of small input cardinality in dimensions $3$, $4$, $5$, $6$, $7$, and $8$. In each dimension, the algorithm either obtains the best BPQS known or find one with fewer inputs., Comment: 18 pages, 1 figure, 10 tables
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- 2024
6. Towards Map-Agnostic Policies for Adaptive Informative Path Planning
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Rückin, Julius, Morilla-Cabello, David, Stachniss, Cyrill, Montijano, Eduardo, and Popović, Marija
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Computer Science - Robotics - Abstract
Robots are frequently tasked to gather relevant sensor data in unknown terrains. A key challenge for classical path planning algorithms used for autonomous information gathering is adaptively replanning paths online as the terrain is explored given limited onboard compute resources. Recently, learning-based approaches emerged that train planning policies offline and enable computationally efficient online replanning performing policy inference. These approaches are designed and trained for terrain monitoring missions assuming a single specific map representation, which limits their applicability to different terrains. To address these issues, we propose a novel formulation of the adaptive informative path planning problem unified across different map representations, enabling training and deploying planning policies in a larger variety of monitoring missions. Experimental results validate that our novel formulation easily integrates with classical non-learning-based planning approaches while maintaining their performance. Our trained planning policy performs similarly to state-of-the-art map-specifically trained policies. We validate our learned policy on unseen real-world terrain datasets., Comment: 8 pages, 4 figures
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- 2024
7. Trimming the Johnson bonsai
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Sánchez, Félix Cabello, Castillo, Jesús M. F., and Moreno, Yolanda
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Mathematics - Functional Analysis ,46B26 - Abstract
We show that if $p>1$ every subspace of $\ell_p(\Gamma)$ is an $\ell_p$-sum of separable subspaces of $\ell_p$, and we provide examples of subspaces of $\ell_p(\Gamma)$ for $0
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- 2024
8. A Multiwavelength Study of the Most Distant Gamma-ray Detected BL Lacertae Object 4FGL J1219.0+3653 ($z=3.59$)
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Hazra, Srijita, Paliya, Vaidehi S., Domínguez, A., Cabello, C., Cardiel, N., and Gallego, J.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
BL Lac objects are a class of jetted active galactic nuclei that do not exhibit or have weak emission lines in their optical spectra. Recently, the first $\gamma$-ray emitting BL Lac beyond $z=3$, 4FGL J1219.0 +3653 (hereafter J1219), was identified, i.e., within the first two billion years of the age of the universe. Here we report the results obtained from a detailed broadband study of this peculiar source by analyzing the new $\sim$58 ksec XMM-Newton and archival observations and reproducing the multiwavelength spectral energy distribution with the conventional one-zone leptonic radiative model. The XMM-Newton~data revealed that J1219 is a faint X-ray emitter ($F_{\rm 0.3-10~keV}=8.39^{+4.11}_{-2.40}\times10^{-15}$ erg/cm2/s) and exhibits a soft spectrum (0.3$-$10 keV photon index$=2.28^{+0.58}_{-0.48}$). By comparing the broadband physical properties of J1219 with $z>3$ $\gamma$-ray detected flat spectrum radio quasars (FSRQs), we have found that it has a relatively low jet power and, similar to FSRQs, the jet power is larger than the accretion disk luminosity. We conclude that deeper multiwavelength observations will be needed to fully explore the physical properties of this unique high-redshift BL Lac object., Comment: JHEAP, in press
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- 2024
9. Brillouin-based storage of QPSK signals with fully tunable phase retrieval
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Saffer, Olivia, Cabello, Jesús Humberto Marines, Becker, Steven, Geilen, Andreas, and Stiller, Birgit
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Physics - Optics ,Physics - Applied Physics - Abstract
Photonic memory is an important building block to delay, route and buffer optical information, for instance in optical interconnects or for recurrent optical signal processing. Photonic-phononic memory based on stimulated Brillouin-Mandelstam scattering (SBS) has been demonstrated as a coherent optical storage approach with broad bandwidth, frequency selectivity and intrinsic nonreciprocity. Here, we experimentally demonstrated the storage of quadrature-phase encoded data at room temperature and at cryogenic temperatures. We store and retrieve the 2-bit states $\{00, 01, 10, 11\}$ encoded as optical pulses with the phases $\{0, {\pi}/2 , {\pi}, 3{\pi}/2\}$ - a quadrature phase shift keying (QPSK) signal. The 2-bit signals are retrieved from the acoustic domain with a global phase rotation of ${\pi}$, which is inherent in the process due to SBS. We also demonstrate full phase control over the retrieved data based on two different handles: by detuning slightly from the SBS resonance, or by changing the storage time in the memory scheme we can cover the full range $[0, 2{\pi})$. At a cryogenic temperature of 3.9 K, we have increased readout efficiency as well as gained access to longer storage times, which results in a detectable signal at 140 ns. All in all, the work sets the cornerstone for optoacoustic memory schemes with phase-encoded data, Comment: O.S. and J.H.M.C. contributed equally to this work
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- 2024
10. Local contextuality-based self-tests are sufficient for randomness expansion secure against quantum adversaries
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Singh, Jaskaran, Foreman, Cameron, Bharti, Kishor, and Cabello, Adán
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Quantum Physics - Abstract
In quantum cryptography, secure randomness expansion involves using a short private string of random bits to generate a longer one, even in the presence of an adversary who may have access to quantum resources. In this work, we demonstrate that local contextuality-based self-tests are sufficient to construct a randomness expansion protocol that is secure against computationally unbounded quantum adversaries. Our protocol is based on self-testing from non-contextuality inequalities and we prove that our scheme asymptotically produces secure random numbers which are $\mathcal{O}(m\sqrt{\epsilon})$-close to uniformly distributed and private, where $\epsilon$ is the robustness parameter of the self-test and $m$ is the length of the generated random bit string. Our protocol is semi-device-independent in the sense that it inherits any assumptions necessary for the underlying self-test., Comment: 5+12 pages. Comments are welcome!
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- 2024
11. Lattice-Based Vulnerabilities in Lee Metric Post-Quantum Cryptosystems
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Horlemann, Anna-Lena, Khathuria, Karan, Newman, Marc, Sakzad, Amin, and Cabello, Carlos Vela
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Computer Science - Cryptography and Security ,Computer Science - Information Theory - Abstract
Post-quantum cryptography has gained attention due to the need for secure cryptographic systems in the face of quantum computing. Code-based and lattice-based cryptography are two prominent approaches, both heavily studied within the NIST standardization project. Code-based cryptography -- most prominently exemplified by the McEliece cryptosystem -- is based on the hardness of decoding random linear error-correcting codes. Despite the McEliece cryptosystem having been unbroken for several decades, it suffers from large key sizes, which has led to exploring variants using metrics than the Hamming metric, such as the Lee metric. This alternative metric may allow for smaller key sizes, but requires further analysis for potential vulnerabilities to lattice-based attack techniques. In this paper, we consider a generic Lee metric based McEliece type cryptosystem and evaluate its security against lattice-based attacks.
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- 2024
12. 'We Are Not Being Taught Sustainable Citizenship!': Podcasts for Critical Science Literacy in Teacher Education
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Valeria M. Cabello, Carmen Gloria Zúñiga, César Amador Valbuena, Franklin Manrique, María Jesús Albarrán, and Ana Moncada-Arce
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Education on sustainability is a crucial goal that requires a transformative shift in teacher education to drive meaningful changes oriented to action. A cross-sectional study with an exploratory design investigated preservice science teachers' perceptions regarding teaching sustainable citizenship, specifically focusing on the climate crisis and earthquakes-tsunamis. The study was conducted in two Chilean universities with similar teacher preparation programs. The team designed a podcast series, which was used and evaluated by the 13 participants through action research. Three group discussions explored their perceptions of the resources, as well as the aims and challenges of teaching sustainable citizenship and the podcasts. We used Grounded Theory steps, including triangulation by the researchers to ensure reliability, to qualitatively analyse the data. The results reveal a constraint on teaching in areas where the participants lacked the necessary preparation and background knowledge as students and preservice teachers. The main challenges were related to interdisciplinarity, the social dimension of socio-scientific issues and context-responsive teaching methods. The perceived aims were the development of students' critical thinking, informed positioning, and encouraging active citizen participation. Preservice teachers found the podcast series to be a valuable new epistemic and pedagogical resource that can support their efforts to teach sustainable citizenship and implement pedagogical strategies. The autonomous usage of the device triggered reflection processes, particularly regarding the human rights perspective, which unveiled the socio-political dimensions inherent in science education. It promoted personal re-positioning as active citizens and educators and empowered them to seek out and pursue the changes needed to reshape future classrooms. We discuss these findings in the context of teacher preparation and the use of educational technology in teacher education.
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- 2024
13. The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder
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M. Kucuker, A. Ozerdem, D. Ceylan, A. Cabello-Arreola, M.C. Ho, B. Joseph, L. Webb, P. Croarkin, M. Frye, and M. Veldic
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major depressive disorder ,Oxidative damage ,DNA repair ,base excision repair ,Psychiatry ,RC435-571 - Abstract
Introduction In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. Objectives This systematic review sought to examine current evidence on the association between mood disorders and deficits in base excision repair (BER), the primary repair mechanism for repair of oxidation-induced DNA lesions. Methods We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD. Results A total of 1,364 records were identified. 1,352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (Single Nucleotide Polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. Conclusions Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response. Disclosure No significant relationships.
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- 2022
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14. Assessing the Distance Teaching-Learning Experience in Higher Technical-Vocational Education in Chile
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Patricio Cabello, Farzane Saadati, and Pía Barahona
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This study aimed to validate a multidimensional instrument for assessing distance teaching-learning. It combined factors measuring motivation with instructional material and the teaching-learning experience with peers and teachers. The instrument was administered to 2,984 higher education students in Chile, demonstrating its statistical validity and adequate fit indicators. Consequently, this instrument can confidently evaluate online learning in higher education.
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- 2024
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15. Assessing the Potential for Densification and VMT Reduction in Areas Without Rail Transit Access
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Kim, Jae Hong, PhD, Barajas, Jesus M., PhD, Marantz, Nicholas J., PhD, Houston, Douglas, PhD, Herrera, Veronica, Okashita, Alex, and Cabello, Maxwell B.
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Housing ,transit oriented development ,land use ,bus transit ,vehicle miles of travel ,travel behavior - Abstract
While transportation infrastructure and efficiency should inform where to build more housing, little is known about how housing allocation and development processes can be coordinated more systematically with transportation. To date, transportation-housing coordination has often relied on the densification of areas near rail transit stations, putting heavy burdens on these locations and their residents. Much less attention has been paid to how densification can be achieved in a more equitable manner by encompassing other sites. This report directs attention to non-rail locations, specifically low vehicle miles traveled (VMT) areas and bus corridors, and examines the challenges that can arise in promoting densification more broadly. It shows that data uncertainties can make it challenging to identify low VMT locations and that prioritizing only low VMT locations for residential development may have limited effectiveness in expanding housing opportunities in high opportunity areas. The report further explores ways to achieve more inclusive densification of non-rail transit areas and highlights the importance of anti-displacement strategies.
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- 2024
16. What Challenges Can Arise from Coordinating Housing Development with Transportation?
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Kim, Jae Hong, Barajas, Jesus M., Marantz, Nicholas J., Houston, Douglas, Herrara, Veronica, Okashita, Alex, and Cabello, Maxwell B.
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More systematic coordination between transportation and housing development is increasingly recognized as a promising strategy for creating more sustainable communities. In California, the importance of transportation-housing coordination is reflected in recent legislative efforts to address the state’s long-standing housing affordability crisis. One approach is to encourage higher density affordable housing developments near transit or in similarly transportation-efficient areas, such as locations with low vehicle miles traveled (VMT). However, little is known about how transportation access should be considered in guiding housing development, what challenges can arise from coordinating housing development with transportation, and what the state can do to better deal with these challenges and achieve more equitable residential densification.
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- 2024
17. PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification
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Fröhlich, Alek, Ramos, Thiago, Cabello, Gustavo, Buzatto, Isabela, Izbicki, Rafael, and Tiezzi, Daniel
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Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Image and Video Processing ,Statistics - Machine Learning - Abstract
Correctly assessing the malignancy of breast lesions identified during ultrasound examinations is crucial for effective clinical decision-making. However, the current "golden standard" relies on manual BI-RADS scoring by clinicians, often leading to unnecessary biopsies and a significant mental health burden on patients and their families. In this paper, we introduce PersonalizedUS, an interpretable machine learning system that leverages recent advances in conformal prediction to provide precise and personalized risk estimates with local coverage guarantees and sensitivity, specificity, and predictive values above 0.9 across various threshold levels. In particular, we identify meaningful lesion subgroups where distribution-free, model-agnostic conditional coverage holds, with approximately 90% of our prediction sets containing only the ground truth in most lesion subgroups, thus explicitly characterizing for which patients the model is most suitably applied. Moreover, we make available a curated tabular dataset of 1936 biopsied breast lesions from a recent observational multicenter study and benchmark the performance of several state-of-the-art learning algorithms. We also report a successful case study of the deployed system in the same multicenter context. Concrete clinical benefits include up to a 65% reduction in requested biopsies among BI-RADS 4a and 4b lesions, with minimal to no missed cancer cases., Comment: 9 pages, 5 figure, 2 tables
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- 2024
18. Searching in Euclidean Spaces with Predictions
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Cabello, Sergio and Giannopoulos, Panos
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Computer Science - Computational Geometry - Abstract
We study the problem of searching for a target at some unknown location in $\mathbb{R}^d$ when additional information regarding the position of the target is available in the form of predictions. In our setting, predictions come as approximate distances to the target: for each point $p\in \mathbb{R}^d$ that the searcher visits, we obtain a value $\lambda(p)$ such that $|p\mathbf{t}|\le \lambda(p) \le c\cdot |p\mathbf{t}|$, where $c\ge 1$ is a fixed constant, $\mathbf{t}$ is the position of the target, and $|p\mathbf{t}|$ is the Euclidean distance of $p$ to $\mathbf{t}$. The cost of the search is the length of the path followed by the searcher. Our main positive result is a strategy that achieves $(12c)^{d+1}$-competitive ratio, even when the constant $c$ is unknown. We also give a lower bound of roughly $(c/16)^{d-1}$ on the competitive ratio of any search strategy in $\mathbb{R}^d$., Comment: 19 pages, WAOA 24
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- 2024
19. Perfect quantum strategies with small input cardinality
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Trandafir, Stefan, Gonzales-Ureta, Junior R., and Cabello, Adán
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Quantum Physics - Abstract
A perfect strategy is one that allows the mutually in-communicated players of a nonlocal game to win every trial of the game. Perfect strategies are basic tools for some fundamental results in quantum computation and crucial resources for some applications in quantum information. Here, we address the problem of producing qudit-qudit perfect quantum strategies with a small number of settings. For that, we exploit a recent result showing that any perfect quantum strategy induces a Kochen-Specker set. We identify a family of KS sets in even dimension $d \ge 6$ that, for many dimensions, require the smallest number of orthogonal bases known: $d+1$. This family was only defined for some $d$. We first extend the family to infinitely many more dimensions. Then, we show the optimal way to use each of these sets to produce a bipartite perfect strategy with minimum input cardinality. As a result, we present a family of perfect quantum strategies in any $(2,d-1,d)$ Bell scenario, with $d = 2^kp^m$ for $p$ prime, $m \geq k \geq 0$ (excluding $m=k=0$), $d = 8p$ for $p \geq 19$, $d=kp$ for $p > ((k-2)2^{k-2})^2$ whenever there exists a Hadamard matrix of order $k$, other sporadic examples, as well as a recursive construction that produces perfect quantum strategies for infinitely many dimensions $d$ from any dimension $d'$ with a perfect quantum strategy. We identify their associated Bell inequalities and prove that they are not tight, which provides a second counterexample to a conjecture of 2007., Comment: 26 pages, 5 figures
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- 2024
20. A proof of the Mond conjecture for wave fronts
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Muñoz-Cabello, C., Nuño-Ballesteros, J. J., and Sinha, R. Oset
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Mathematics - Algebraic Geometry ,Primary 32S30, Secondary 32S25, 58K60 - Abstract
We prove the Mond conjecture for wave fronts which states that the number of parameters of a frontal versal unfolding is less than or equal to the number of spheres in the image of a stable frontal deformation with equality if the wave front is weighted homogeneous. We give two different proofs. The first one depends on the fact that wave fronts are related to discriminants of map germs and we then use the analogous result proved by Damon and Mond in this context. The second one is based on ideas by Fern\'andez de Bobadilla, Nu\~no-Ballesteros and Pe\~nafort Sanchis and by Nu\~no-Ballesteros and Fern\'andez-Hern\'andez. The advantage of the second approach is that most results are valid for any frontal, not only wave fronts, and thus give important tools which may be useful to prove the conjecture for frontals in general., Comment: 21 pages, 4 figures
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- 2024
21. Connected Matchings
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Aichholzer, Oswin, Cabello, Sergio, Mészáros, Viola, Schnider, Patrick, and Soukup, Jan
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Computer Science - Computational Geometry ,Mathematics - Combinatorics - Abstract
We show that each set of $n\ge 2$ points in the plane in general position has a straight-line matching with at least $(5n+1)/27$ edges whose segments form a connected set, and such a matching can be computed in $O(n \log n)$ time. As an upper bound, we show that for some planar point sets in general position the largest matching whose segments form a connected set has $\lceil \frac{n-1}{3}\rceil$ edges. We also consider a colored version, where each edge of the matching should connect points with different colors., Comment: 20 pages, 14 figures; preliminary version in EuroCG 2024
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- 2024
22. Experimental Quantum Advantage in the Odd-Cycle Game
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Drmota, P., Main, D., Ainley, E. M., Agrawal, A., Araneda, G., Nadlinger, D. P., Nichol, B. C., Srinivas, R., Cabello, A., and Lucas, D. M.
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Quantum Physics - Abstract
We report the first experimental demonstration of the odd-cycle game. We entangle two ions separated by ~2 m and the players use them to win the odd-cycle game with a probability ~26 sigma above that allowed by the best classical strategy. The experiment implements the optimal quantum strategy, is free of loopholes, and achieves 97.8(3) % of the theoretical limit to the quantum winning probability. We perform the associated Bell test and measure a nonlocal content of 0.54(2) -- the largest value for physically separate devices, free of the detection loophole, ever observed.
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- 2024
23. Generating multipartite nonlocality to benchmark quantum computers
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Bönsel, Jan Lennart, Gühne, Otfried, and Cabello, Adán
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Quantum Physics - Abstract
We show that quantum computers can be used for producing large $n$-partite nonlocality, thereby providing a method to benchmark them. The main challenges to overcome are: (i) The interaction topology might not allow arbitrary two-qubit gates. (ii) Noise limits the Bell violation. (iii) The number of combinations of local measurements grows exponentially with $n$. To overcome (i), we point out that graph states that are compatible with the two-qubit connectivity of the computer can be efficiently prepared. To mitigate (ii), we note that, for specific graph states, there are $n$-partite Bell inequalities whose resistance to white noise increases exponentially with $n$. To address (iii) for any $n$ and any connectivity, we introduce an estimator that relies on random sampling. As a result, we propose a method for producing $n$-partite Bell nonlocality with unprecedented large $n$. This allows in return to benchmark nonclassical correlations regardless of the number of qubits or the connectivity. We test our approach by using a simulation for a noisy IBM quantum computer, which predicts $n$-partite Bell nonlocality for at least $n=24$ qubits., Comment: 14 pages, 13 figures; Improvements in the presentation and the noise model
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- 2024
24. Risk-reducing surgeries for breast cancer in Brazilian patients undergoing multigene germline panel: impact of results on decision making
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Duarte, Bárbara Narciso, Alem, Christine Elisabete Rubio, da Silva Cabello, Ana Elisa Ribeiro, Teixeira, Sandra Regina Campos, and Cabello, Cesar
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- 2024
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25. Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
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María J. Ruiz-de-León, María A. Jiménez-Sousa, Santiago Moreno, Marcial García, Mónica Gutiérrez-Rivas, Agathe León, Marta Montero-Alonso, Juan González-García, Salvador Resino, Norma Rallón, José M. Benito, Alejandro Vallejo, J.M. Benito, N. Rallón, C. Restrepo, N. Rodríguez, M. García, A. Cabello, M. Gorgolas, S. Resino, V. Briz, M.A. Jiménez, M.S. Vázquez, A. Fernández, P. García, M.A. Muñoz, J. Sánchez, J.L. Jiménez, D. Sepúlveda, I. García, I. Consuegra, A. León, M. Arnedo, M. Plana, N. Climent, F. García, E. Ruiz-Mateos, B. Domínguez, L. Tarancón, M. Rafii-El-Idrissi, M.J. Polaino, M. Genebat, P. Viciana, M. Leal, F. Vidal, E. Rodríguez, C. Viladés, J. Peraire, J. Romero, C Rodríguez, M. Vera, J. Esté, E. Ballana, M.A. Martínez, S. Franco, M. Nevot, A. Vallejo, S. Moreno, M. Pernas, C. Casado, C. López, L. Capa, M. Pérez, J. Alcami, R. Sanjuán, J.M. Cueva, R. Delgado, O. Sierra, and A. Valenzuela
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Microbiology ,QR1-502 - Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Keywords: Exosomes, miRNAs, HIV-1, Elite controllers, Immune activation, Soluble biomarkers
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- 2019
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26. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.
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Jiang, Yuchao, Luo, Cheng, Wang, Jijun, Palaniyappan, Lena, Chang, Xiao, Xiang, Shitong, Zhang, Jie, Duan, Mingjun, Huang, Huan, Gaser, Christian, Nemoto, Kiyotaka, Miura, Kenichiro, Hashimoto, Ryota, Westlye, Lars, Richard, Genevieve, Fernandez-Cabello, Sara, Parker, Nadine, Andreassen, Ole, Kircher, Tilo, Nenadić, Igor, Stein, Frederike, Thomas-Odenthal, Florian, Teutenberg, Lea, Usemann, Paula, Dannlowski, Udo, Hahn, Tim, Grotegerd, Dominik, Meinert, Susanne, Lencer, Rebekka, Tang, Yingying, Zhang, Tianhong, Li, Chunbo, Yue, Weihua, Zhang, Yuyanan, Yu, Xin, Zhou, Enpeng, Lin, Ching-Po, Tsai, Shih-Jen, Rodrigue, Amanda, Glahn, David, Pearlson, Godfrey, Blangero, John, Karuk, Andriana, Pomarol-Clotet, Edith, Salvador, Raymond, Fuentes-Claramonte, Paola, Garcia-León, María, Spalletta, Gianfranco, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Cheng, Jingliang, Liu, Zhening, Yang, Jie, Gonul, Ali, Uslu, Ozgul, Burhanoglu, Birce, Uyar Demir, Aslihan, Rootes-Murdy, Kelly, Calhoun, Vince, Sim, Kang, Green, Melissa, Quidé, Yann, Chung, Young, Kim, Woo-Sung, Sponheim, Scott, Demro, Caroline, Ramsay, Ian, Iasevoli, Felice, de Bartolomeis, Andrea, Barone, Annarita, Ciccarelli, Mariateresa, Brunetti, Arturo, Cocozza, Sirio, Pontillo, Giuseppe, Tranfa, Mario, Park, Min, Kirschner, Matthias, Georgiadis, Foivos, Kaiser, Stefan, Van Rheenen, Tamsyn, Rossell, Susan, Hughes, Matthew, Woods, William, Carruthers, Sean, Sumner, Philip, Ringin, Elysha, Spaniel, Filip, Skoch, Antonin, Tomecek, David, Homan, Philipp, Homan, Stephanie, Omlor, Wolfgang, Cecere, Giacomo, Nguyen, Dana, Preda, Adrian, Thomopoulos, Sophia, Jahanshad, Neda, Cui, Long-Biao, and Yao, Dezhong
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Humans ,Schizophrenia ,Male ,Female ,Adult ,Algorithms ,Magnetic Resonance Imaging ,Gray Matter ,Machine Learning ,Middle Aged ,Brain ,Cross-Sectional Studies ,Europe ,Neuroimaging ,Reproducibility of Results ,North America ,Hippocampus - Abstract
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal trajectory of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
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- 2024
27. It is Simple Sometimes: A Study On Improving Aspect-Based Sentiment Analysis Performance
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Cabello, Laura and Akujuobi, Uchenna
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Computer Science - Computation and Language - Abstract
Aspect-Based Sentiment Analysis (ABSA) involves extracting opinions from textual data about specific entities and their corresponding aspects through various complementary subtasks. Several prior research has focused on developing ad hoc designs of varying complexities for these subtasks. In this paper, we present a generative framework extensible to any ABSA subtask. We build upon the instruction tuned model proposed by Scaria et al. (2023), who present an instruction-based model with task descriptions followed by in-context examples on ABSA subtasks. We propose PFInstruct, an extension to this instruction learning paradigm by appending an NLP-related task prefix to the task description. This simple approach leads to improved performance across all tested SemEval subtasks, surpassing previous state-of-the-art (SOTA) on the ATE subtask (Rest14) by +3.28 F1-score, and on the AOOE subtask by an average of +5.43 F1-score across SemEval datasets. Furthermore, we explore the impact of the prefix-enhanced prompt quality on the ABSA subtasks and find that even a noisy prefix enhances model performance compared to the baseline. Our method also achieves competitive results on a biomedical domain dataset (ERSA)., Comment: Accepted to ACL 2024 Findings
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- 2024
28. Eliminating Crossings in Ordered Graphs
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Agrawal, Akanksha, Cabello, Sergio, Kaufmann, Michael, Saurabh, Saket, Sharma, Roohani, Uno, Yushi, and Wolff, Alexander
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Computer Science - Computational Geometry - Abstract
Drawing a graph in the plane with as few crossings as possible is one of the central problems in graph drawing and computational geometry. Another option is to remove the smallest number of vertices or edges such that the remaining graph can be drawn without crossings. We study both problems in a book-embedding setting for ordered graphs, that is, graphs with a fixed vertex order. In this setting, the vertices lie on a straight line, called the spine, in the given order, and each edge must be drawn on one of several pages of a book such that every edge has at most a fixed number of crossings. In book embeddings, there is another way to reduce or avoid crossings; namely by using more pages. The minimum number of pages needed to draw an ordered graph without any crossings is its (fixed-vertex-order) page number. We show that the page number of an ordered graph with $n$ vertices and $m$ edges can be computed in $2^m \cdot n^{O(1)}$ time. An $O(\log n)$-approximation of this number can be computed efficiently. We can decide in $2^{O(d \sqrt{k} \log (d+k))} \cdot n^{O(1)}$ time whether it suffices to delete $k$ edges of an ordered graph to obtain a $d$-planar layout (where every edge crosses at most $d$ other edges) on one page. As an additional parameter, we consider the size $h$ of a hitting set, that is, a set of points on the spine such that every edge, seen as an open interval, contains at least one of the points. For $h=1$, we can efficiently compute the minimum number of edges whose deletion yields fixed-vertex-order page number $p$. For $h>1$, we give an XP algorithm with respect to $h+p$. Finally, we consider spine+$t$-track drawings, where some but not all vertices lie on the spine. The vertex order on the spine is given; we must map every vertex that does not lie on the spine to one of $t$ tracks, each of which is a straight line on a separate page, parallel to the spine., Comment: Appears in Proc. 19th Scandinavian Symposium on Algorithm Theory (SWAT 2024)
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- 2024
29. Pseudo-MRI-Guided PET Image Reconstruction Method Based on a Diffusion Probabilistic Model
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Gan, Weijie, Xie, Huidong, von Gall, Carl, Platsch, Günther, Jurkiewicz, Michael T., Andrade, Andrea, Anazodo, Udunna C., Kamilov, Ulugbek S., An, Hongyu, and Cabello, Jorge
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Anatomically guided PET reconstruction using MRI information has been shown to have the potential to improve PET image quality. However, these improvements are limited to PET scans with paired MRI information. In this work we employed a diffusion probabilistic model (DPM) to infer T1-weighted-MRI (deep-MRI) images from FDG-PET brain images. We then use the DPM-generated T1w-MRI to guide the PET reconstruction. The model was trained with brain FDG scans, and tested in datasets containing multiple levels of counts. Deep-MRI images appeared somewhat degraded than the acquired MRI images. Regarding PET image quality, volume of interest analysis in different brain regions showed that both PET reconstructed images using the acquired and the deep-MRI images improved image quality compared to OSEM. Same conclusions were found analysing the decimated datasets. A subjective evaluation performed by two physicians confirmed that OSEM scored consistently worse than the MRI-guided PET images and no significant differences were observed between the MRI-guided PET images. This proof of concept shows that it is possible to infer DPM-based MRI imagery to guide the PET reconstruction, enabling the possibility of changing reconstruction parameters such as the strength of the prior on anatomically guided PET reconstruction in the absence of MRI.
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- 2024
30. Small-scale magnetic flux emergence preceding a chain of energetic solar atmospheric events
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Nóbrega-Siverio, D., Cabello, I., Bose, S., van der Voort, L. H. M. Rouppe, Joshi, R., Froment, C., and Henriques, V. M. J.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Advancements in instrumentation have revealed a multitude of small-scale EUV events in the solar atmosphere. Our aim is to employ high-resolution magnetograms to gain a detailed understanding of the magnetic origin of such phenomena. We have used coordinated observations from SST, IRIS, and SDO to analyze an ephemeral magnetic flux emergence episode and the following chain of small-scale energetic events. These unique observations clearly link these phenomena together. The high-resolution (0."057/pixel) magnetograms obtained with SST/CRISP allows us to reliably measure the magnetic field at the photosphere and detect the emerging bipole that causes the subsequent eruptive atmospheric events. Notably, this small-scale emergence episode remains indiscernible in the lower resolution SDO/HMI magnetograms (0."5/pixel). We report the appearance of a dark bubble in Ca II K related to the emerging bipole, a sign of the canonical expanding magnetic dome predicted in flux emergence simulations. Evidences of reconnection are also found: first through an Ellerman bomb, and later by the launch of a surge next to a UV burst. The UV burst exhibits a weak EUV counterpart in the coronal SDO/AIA channels. By calculating DEM, its plasma is shown to reach a temperature beyond 1 MK and have densities between the upper chromosphere and transition region. Our study showcases the importance of high-resolution magnetograms to unveil the mechanisms triggering phenomena such as EBs, UV bursts, and surges. This could hold implications for small-scale events akin to those recently reported in EUV using Solar Orbiter. The finding of temperatures beyond 1 MK in the UV burst plasma strongly suggests that we are examining analogous features. Therefore, we signal caution regarding drawing conclusions from full-disk magnetograms that lack the necessary resolution to reveal their true magnetic origin., Comment: Accepted in A&A, 11 pages, 7 figures, 5 movies
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- 2024
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31. Impact of 1-Methylcyclopropene in Combination with Heat Shock and Dimethyl Dicarbonate on the Physicochemical Profiles of Table Olive Fermentations
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López-García, Elio, Benítez-Cabello, Antonio, Rodríguez-Gómez, Francisco, Martín-Arranz, Virginia, Romero-Gil, Verónica, Arroyo-López, Francisco Noé, and Garrido-Fernández, Antonio
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- 2024
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32. Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery: lessons from a case series
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Boccuni, Leonardo, Roca-Ventura, Alba, Buloz-Osorio, Edgar, Leno-Colorado, David, Delgado-Gallén, Selma, Cabello-Toscano, María, Perellón-Alfonso, Ruben, Villalba-Martínez, Gloria, Martínez-Ricarte, Francisco, Martín-Fernández, Jesús, Buxeda-Rodriguez, Mònica, Conesa-Bertrán, Gerardo, Illueca-Moreno, Mireia, Lladó-Carbó, Estela, Perla y Perla, Cristóbal, Garrido, César, Pariente, José Carlos, Laredo, Carlos, Muñoz-Moreno, Emma, Bargalló, Núria, Trompetto, Carlo, Marinelli, Lucio, Bartrés-Faz, David, Abellaneda-Pérez, Kilian, Pascual-Leone, Alvaro, and Tormos-Muñoz, Josep María
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- 2024
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33. Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis
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Riera-Serra, Pau, Navarra-Ventura, Guillem, Castro, Adoración, Gili, Margalida, Salazar-Cedillo, Angie, Ricci-Cabello, Ignacio, Roldán-Espínola, Lorenzo, Coronado-Simsic, Victoria, García-Toro, Mauro, Gómez-Juanes, Rocío, and Roca, Miquel
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- 2024
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34. Prevalence of Human Toxoplasmosis in Spain Throughout the Three Last Decades (1993–2023): A Systematic Review and Meta-analysis
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Miguel-Vicedo, Mariola, Cabello, Paula, Ortega-Navas, M. Carmen, González-Barrio, David, and Fuentes, Isabel
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- 2024
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35. Perfil revisado: Vicente Aleixandre, Antonio Machado y otros lectores de Carolina Coronado en la Edad de Plata
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Cabello, Estefanía
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- 2024
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36. Teachers’ Scientific Explanation Practices: Opportunities for Equity
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Cabello, Valeria M. and Geelan, David
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- 2024
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37. Volterra operator acting on Bergman spaces of Dirichlet series
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Gómez-Cabello, Carlos, Lefèvre, Pascal, and Queffélec, Hervé
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Mathematics - Functional Analysis ,Mathematics - Complex Variables - Abstract
Since their introduction in 1997, the Hardy spaces of Dirichlet series have been broadly and deeply studied. The increasing interest sparked by these Banach spaces of Dirichlet series motivated the introduction of new such spaces, as the Bergman spaces of Dirichlet series $\mathcal{A}^p_{\mu}$ here considered, where $\mu$ is a probability measure on $(0,\infty)$. Similarly, recent lines of research have focused their attention on the study of some classical operators acting on these spaces, as it is the case of the Volterra operator $T_g$. In this work, we introduce a new family of Bloch spaces of Dirichlet series, the $\text{Bloch}_{\mu}$-spaces, and study some of its most essential properties. Using these spaces we are able to provide a sufficient condition for the Volterra operator $T_g$ to act boundedly on the Bergman spaces $\mathcal{A}^p_{\mu}$. We also establish a necessary condition for a specific choice of the probability measures $\mu$. Sufficient and necessary conditions for compactness are also proven. The membership in Schatten classes is studied as well. Eventually, a radicality result is established for Bloch spaces of Dirichlet series., Comment: Main changes in Section 3 and Section 7. Some results have been improved and some proofs have been written more clearly
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- 2024
38. Integration type operators and point evaluation on weighted Bergman spaces of Dirichlet series
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Gómez-Cabello, Carlos, Lefèvre, Pascal, and Queffélec, Hervé
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Mathematics - Complex Variables ,Mathematics - Functional Analysis - Abstract
The theory of Banach spaces of Dirichlet series has drawn an increasing attention in the recent 25 years. One of the main interest of this new theory is that of defining analogues of the classical spaces of analytic functions on the unit disc. In this sense, Bergman spaces were introduced several years ago contributing to broaden the picture of this theory. In the paper presenting these new family of spaces, some of its most essential questions were considered. Among them, some partial estimates of the norm of the pointwise evaluation functional were given. In this work, we introduce a version of the Riemann-Liouville semigroup acting on these spaces, and, with this new tool, we are able to estimate the norm of this functional., Comment: Somo general corrections in order to ease the reading and the statements of the results
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- 2024
39. A characterisation of Euclidean normed planes via bisectors
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Sánchez, Javier Cabello and Gordillo-Merino, Adrián
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Mathematics - Metric Geometry - Abstract
Our main result states that whenever we have a non-Euclidean norm $\|\cdot\|$ on a two-dimensional vector space $X$, there exists some $x\neq 0$ such that for every $\lambda\neq 1, \lambda>0$, there exist $y, z\in X$ verifying that $\|y\|=\lambda\|x\|$, $z\neq 0$, and $z$ belongs to the bisectors $B(-x,x)$ and $B(-y,y)$. Throughout this paper we also state and prove some other simple but maybe useful results about the geometry of the unit sphere of strictly convex planes.
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- 2024
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40. TAC Method for Fitting Exponential Autoregressive Models and Others: Applications in Economy and Finance
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Sánchez, Javier Cabello, Torvisco, Juan Antonio Fernández, and Arias, Mariano R.
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Mathematics - Numerical Analysis ,Quantitative Finance - Statistical Finance - Abstract
There are a couple of purposes in this paper: to study a problem of approximation with exponential functions and to show its relevance for the economic science. We present results that completely solve the problem of the best approximation by means of exponential functions and we will be able to determine what kind of data is suitable to be fitted. Data will be approximated using TAC (implemented in the R-package nlstac), a numerical algorithm for fitting data by exponential patterns without initial guess designed by the authors. We check one more time the robustness of this algorithm by successfully applying it to two very distant areas of economy: demand curves and nonlinear time series. This shows TAC's utility and highlights how far this algorithm could be used.
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- 2024
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41. nlstac: Non-Gradient Separable Nonlinear Least Squares Fitting
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Torvisco, J. A. F., Benítez, R., Arias, M. R., and Sánchez, J. Cabello
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Mathematics - Statistics Theory - Abstract
A new package for nonlinear least squares fitting is introduced in this paper. This package implements a recently developed algorithm that, for certain types of nonlinear curve fitting, reduces the number of nonlinear parameters to be fitted. One notable feature of this method is the absence of initialization which is typically necessary for nonlinear fitting gradient-based algorithms. Instead, just some bounds for the nonlinear parameters are required. Even though convergence for this method is guaranteed for exponential decay using the max-norm, the algorithm exhibits remarkable robustness, and its use has been extended to a wide range of functions using the Euclidean norm. Furthermore, this data-fitting package can also serve as a valuable resource for providing accurate initial parameters to other algorithms that rely on them.
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- 2024
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42. A natural correspondence between quasiconcave functions and fuzzy norms
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Sánchez, Javier Cabello and González, Daniel Morales
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Mathematics - Metric Geometry - Abstract
In this note we show that the usual notion of fuzzy norm defined on a linear space is equivalent to that of quasiconcave function, in the sense that every fuzzy norm $N:X\times\mathbb{R}[0,1]$ defined on a (real or complex) linear space X is uniquely determined by a quasiconcave function $f:X\to[0, 1]$. We explore the minimum requirements that we need to impose to some quasiconcave function $f:X\to[0, 1]$ in order to define a fuzzy norm $N:X\times\mathbb{R}[0,1]$. Later we use this equivalence to prove some properties of fuzzy norms, like a generalisation of the celebrated Decomposition Theorem.
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- 2024
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43. Test of the physical significance of Bell nonlocality
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Vieira, Carlos, Ramanathan, Ravishankar, and Cabello, Adán
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Quantum Physics - Abstract
The experimental violation of a Bell inequality implies that at least one of a set of assumptions fails in nature. However, existing tests are inconclusive about which of the assumptions is the one that fails. Here, we show that there are quantum correlations that cannot be simulated with hidden variables that allow the slightest free will (or, equivalently, that limit, even minimally, retrocausal influences) or restrict, even minimally, actions at a distance. This result goes beyond Bell's theorem and demolishes the arguably most attractive motivation for considering hidden-variable theories with measurement dependence or actions at distance, namely, that simulating quantum correlations typically requires a small amount of these resources. We show that there is a feasible experiment that can discard any hidden-variable theory allowing for arbitrarily small free will and having arbitrarily small limitations to actions at a distance. The experiment involves two observers, each of them choosing between two measurements with $2^N$ outcomes. The larger $N$ for which a specific Bell-like inequality is violated, the larger the set of excluded hidden-variable theories. In the limit of $N$ tending to infinity, the only alternatives to the absence of hidden variables are complete superdeterminism or complete parameter dependence. We also explore the implications of this result for quantum information., Comment: 6+18 pages, 1 figure, 1 table
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- 2024
44. CADICA: a new dataset for coronary artery disease detection by using invasive coronary angiography
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Jiménez-Partinen, Ariadna, Molina-Cabello, Miguel A., Thurnhofer-Hemsi, Karl, Palomo, Esteban J., Rodríguez-Capitán, Jorge, Molina-Ramos, Ana I., and Jiménez-Navarro, Manuel
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Coronary artery disease (CAD) remains the leading cause of death globally and invasive coronary angiography (ICA) is considered the gold standard of anatomical imaging evaluation when CAD is suspected. However, risk evaluation based on ICA has several limitations, such as visual assessment of stenosis severity, which has significant interobserver variability. This motivates to development of a lesion classification system that can support specialists in their clinical procedures. Although deep learning classification methods are well-developed in other areas of medical imaging, ICA image classification is still at an early stage. One of the most important reasons is the lack of available and high-quality open-access datasets. In this paper, we reported a new annotated ICA images dataset, CADICA, to provide the research community with a comprehensive and rigorous dataset of coronary angiography consisting of a set of acquired patient videos and associated disease-related metadata. This dataset can be used by clinicians to train their skills in angiographic assessment of CAD severity and by computer scientists to create computer-aided diagnostic systems to help in such assessment. In addition, baseline classification methods are proposed and analyzed, validating the functionality of CADICA and giving the scientific community a starting point to improve CAD detection.
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- 2024
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45. Lifting noncontextuality inequalities
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Choudhary, Raman, Barbosa, Rui Soares, and Cabello, Adán
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Quantum Physics - Abstract
Kochen-Specker contextuality is a fundamental feature of quantum mechanics and a crucial resource for quantum computational advantage and reduction of communication complexity. Its presence is witnessed in empirical data by the violation of noncontextuality inequalities. However, all known noncontextuality inequalities corresponding to facets of noncontextual polytopes are either Bell inequalities or refer to cyclic or state-independent contextuality scenarios. We introduce a general method for lifting noncontextuality inequalities, deriving facets of noncontextual polytopes for more complex scenarios from known facets of simpler subscenarios. Concretely, starting from an arbitrary scenario, the addition of a new measurement or a new outcome preserves the facet-defining nature of any noncontextuality inequality. This extends the results of Pironio [J. Math. Phys. 46, 062112 (2005)] from Bell nonlocality scenarios to contextuality scenarios, unifying liftings of Bell and noncontextuality inequalities. Our method produces facet-defining noncontextuality inequalities in all scenarios with contextual correlations, and we present examples of facet-defining noncontextuality inequalities for scenarios where no examples were known. Our results shed light on the structure of noncontextuality polytopes and the relationship between such polytopes across different scenarios., Comment: 20 pages, 4 figures
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- 2024
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46. Sexual network characteristics, condomless anal intercourse, and the HIV care cascade among MSM living with controlled versus uncontrolled HIV infection in Lima, Peru: a population-based cross-sectional analysis
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Harris, Carlyn L, Blair, Cherie S, Segura, Eddy R, Gutiérrez, Jessica, Lake, Jordan E, Cabello, Robinson, and Clark, Jesse L
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Sciences ,HIV/AIDS ,Sexually Transmitted Infections ,Behavioral and Social Science ,Prevention ,Pediatric AIDS ,Pediatric ,Infectious Diseases ,Clinical Research ,Sexual and Gender Minorities (SGM/LGBT*) ,Infection ,Good Health and Well Being ,HIV prevention ,Sexual networks ,Men who have sex with men ,Sexually transmitted infections ,Detectable viremia - Abstract
BackgroundDespite high rates of HIV transmission among men who have sex with men (MSM) in Lima, Peru, limited data exist on the sexual network characteristics or risk factors for secondary HIV transmission among MSM with uncontrolled HIV infection. We report the frequency of serodiscordant, condomless anal intercourse (CAI) and associated sexual network characteristics among MSM in Lima with detectable HIV viremia and compare to those with undetectable viremia.MethodsThis cross-sectional analysis includes MSM who tested positive for HIV-1 during screening for a trial of partner management and STI control (June 2022-January 2023). Participants were tested for HIV, gonorrhoea, chlamydia, and syphilis, and completed questionnaires on their demographic characteristics, sexual identity and behaviour, sexual network structures and engagement in HIV care.FindingsOf 665 MSM, 153 (23%) had detectable (>200 copies/mL) viremia. 75% (499/662) of men living with HIV were previously diagnosed, with 94% (n = 469/499) reporting that they were on ART, and 93% (n = 436/469) virally suppressed. 96% (n = 147/153) of men with detectable viremia reported serodiscordant CAI with at least one of their last three sexual partners, and 74% (n = 106/144) reported the same with all three of their recent partners. In contrast, 62% (n = 302/489) of men with undetectable viral load reported serodiscordant CAI with all of their last three partners (p
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- 2024
47. Changes in Inflammatory Cytokine Levels in Rectal Mucosa Associated With Neisseria gonorrheae and/or Chlamydia trachomatis Infection and Treatment Among Men Who Have Sex With Men in Lima, Peru.
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Clark, Jesse, Oldenburg, Catherine, Passaro, Ryan, Segura, Eddy, Godwin, William, Fulcher, Jennifer, and Cabello, Robinson
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Chlamydia trachomatis ,Neisseria gonorrheae ,HIV-1 ,HIV-1 prevention ,MSM ,chlamydia ,cytokines ,gonorrhea ,inflammation ,rectal mucosa ,Male ,Humans ,Homosexuality ,Male ,Gonorrhea ,Chlamydia trachomatis ,Cytokines ,Peru ,Sexual and Gender Minorities ,Neisseria gonorrhoeae ,Chlamydia Infections ,Rectal Diseases ,Mucous Membrane ,HIV-1 ,Inflammation ,HIV Infections ,Prevalence - Abstract
BACKGROUND: Neisseria gonorrheae and Chlamydia trachomatis are associated with mucosal inflammation and human immunodeficiency virus 1 (HIV-1) transmission. We assessed levels of inflammatory cytokines in men who have sex with men (MSM) with and without rectal gonorrhea and/or chlamydia in Lima, Peru. METHODS: We screened 605 MSM reporting condomless receptive anal intercourse for rectal N. gonorrheae/C. trachomatis using nucleic acid testing. We identified 101 cases of gonorrhea and/or chlamydia and randomly selected 50 N. gonorrheae/C. trachomatis positive cases and matched 52 negative controls. We measured levels of IL-1β, IL-6, IL-8, and TNF-α in rectal secretions. Tests for HIV-1, rectal N. gonorrheae/C. trachomatis, and mucosal cytokines were repeated after 3 and 6 months. Cytokine levels in cases and uninfected controls were compared using Wilcoxon rank-sum tests and linear regression. RESULTS: MSM with gonorrhea/chlamydia had elevated levels of all cytokines in rectal mucosa compared with matched controls (all P values .05). DISCUSSION: Rectal gonorrhea/chlamydia infection is associated with transient mucosal inflammation and cytokine recruitment. Our data provide proof of concept for rectal sexually transmitted infection screening as an HIV prevention strategy for MSM. Clinical Trials Registration. NCT03010020.
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- 2024
48. A Note on the 2-Colored Rectilinear Crossing Number of Random Point Sets in the Unit Square
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Cabello, Sergio, Czabarka, Éva, Fabila-Monroy, Ruy, Higashikawa, Yuya, Seidel, Raimund, Székely, László, Tkadlec, Josef, and Wesolek, Alexandra
- Subjects
Mathematics - Combinatorics ,Computer Science - Computational Geometry - Abstract
Let $S$ be a set of four points chosen independently, uniformly at random from a square. Join every pair of points of $S$ with a straight line segment. Color these edges red if they have positive slope and blue, otherwise. We show that the probability that $S$ defines a pair of crossing edges of the same color is equal to $1/4$. This is connected to a recent result of Aichholzer et al. [GD 2019] who showed that by 2-colouring the edges of a geometric graph and counting monochromatic crossings instead of crossings, the number of crossings can be more than halfed. Our result shows that for the described random drawings, there is a coloring of the edges such that the number of monochromatic crossings is in expectation $\frac{1}{2}-\frac{7}{50}$ of the total number of crossings.
- Published
- 2023
49. Caracterización clínicoepidemiológica de pacientes con enfermedades reumáticas de inicio juvenil en Paraguay (2011 – 2015)
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N. Cabrera, M. Cabrera, G. Cattivelli, M. Rojas, Y. Barofaldi, P. Delgadillo, A. Campuzano, J. Mazzoleni, E. Paredes, C. Vega, A. Arbo, Z. Morel, G. Ávila-Pedretti, P. Ramos, M. Villafañe, S. Irala, E. Pedrozo, V. G. Sequera, and A. Cabello
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reumatismos inflamatorios ,juveniles ,epidemiología ,reumatología pediátrica ,carga de enfermedad ,Internal medicine ,RC31-1245 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objetivo: Describir la frecuencia de las enfermedades reumatológicas inflamatorias de inicio juvenil (RI J) en hospitales de nivel de complejidad III y IV en un quinquenio. Método: Estudio multicéntrico, descriptivo, retrospectivo utilizando códigos CI E-10 de los archivos de hospitales de Asunción y del departamento central. Resultados: Cuatro archivos hospitalarios fueron incluidos. En total 382 pacientes cumplían los criterios de inclusión. El sex ratio (M: F) de la población fue de 1:1.6, edad promedio a la captación de 11.6 años (DE±4.5). El grupo de pacientes con Enfermedad de Kawasaki tenían edad promedio de 5.4 años (± 3.7 DE) y los pacientes con Lupus Eritematoso Sistémico (LES) se presentaron con 13.1 años (± 3.9 DE). El 68,6% de los pacientes fueron captados por consulta especializada de seguimiento. La artritis idiopática juvenil fue la enfermedad RIJ más frecuentemente diagnosticada (n=167 casos, 43,7% del total), seguida por el LES (n=130, 34,0%). La mayoría de los casos (75.9%, n=290) eran pacientes procedentes (al nacimiento) de Asunción o del departamento central. Conclusión: El espectro de las enfermedades RI J es amplio con distribución variable según los hospitales incluidos. Este estudio orienta a conocer la “carga de enfermedad” por enfermedades RI J en Paraguay.
- Published
- 2017
50. The effect of cognitive reserve on the cognitive connectome in healthy ageing
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Habich, Annegret, Garcia-Cabello, Eloy, Abbatantuono, Chiara, Gonzalez-Burgos, Lissett, Taurisano, Paolo, Dierks, Thomas, Barroso, José, and Ferreira, Daniel
- Published
- 2024
- Full Text
- View/download PDF
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