21,341 results on '"A. Molinaro"'
Search Results
2. The Power of Migrations in Dynamic Bin Packing
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Mellou, Konstantina, Molinaro, Marco, and Zhou, Rudy
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Computer Science - Data Structures and Algorithms - Abstract
In the Dynamic Bin Packing problem, $n$ items arrive and depart the system in an online manner, and the goal is to maintain a good packing throughout. We consider the objective of minimizing the total active time, i.e., the sum of the number of open bins over all times. An important tool for maintaining an efficient packing in many applications is the use of migrations; e.g., transferring computing jobs across different machines. However, there are large gaps in our understanding of the approximability of dynamic bin packing with migrations. Prior work has covered the power of no migrations and $> n$ migrations, but we ask the question: What is the power of limited ($\leq n$) migrations? Our first result is a dichotomy between no migrations and linear migrations: Using a sublinear number of migrations is asymptotically equivalent to doing zero migrations, where the competitive ratio grows with $\mu$, the ratio of the largest to smallest item duration. On the other hand, we prove that for every $\alpha \in (0,1]$, there is an algorithm that does $\approx \alpha n$ migrations and achieves competitive ratio $\approx 1/\alpha$ (in particular, independent of $\mu$); we also show that this tradeoff is essentially best possible. This fills in the gap between zero migrations and $> n$ migrations in Dynamic Bin Packing. Finally, in light of the above impossibility results, we introduce a new model that more directly captures the impact of migrations. Instead of limiting the number of migrations, each migration adds a delay of $C$ time units to the item's duration; this commonly appears in settings where a blackout or set-up time is required before the item can restart its execution in the new bin. In this new model, we prove a $O(\min (\sqrt{C}, \mu))$-approximation, and an almost matching lower bound.
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- 2024
3. Say My Name: a Model's Bias Discovery Framework
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Ciranni, Massimiliano, Molinaro, Luca, Barbano, Carlo Alberto, Fiandrotti, Attilio, Murino, Vittorio, Pastore, Vito Paolo, and Tartaglione, Enzo
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
In the last few years, due to the broad applicability of deep learning to downstream tasks and end-to-end training capabilities, increasingly more concerns about potential biases to specific, non-representative patterns have been raised. Many works focusing on unsupervised debiasing usually leverage the tendency of deep models to learn ``easier'' samples, for example by clustering the latent space to obtain bias pseudo-labels. However, the interpretation of such pseudo-labels is not trivial, especially for a non-expert end user, as it does not provide semantic information about the bias features. To address this issue, we introduce ``Say My Name'' (SaMyNa), the first tool to identify biases within deep models semantically. Unlike existing methods, our approach focuses on biases learned by the model. Our text-based pipeline enhances explainability and supports debiasing efforts: applicable during either training or post-hoc validation, our method can disentangle task-related information and proposes itself as a tool to analyze biases. Evaluation on traditional benchmarks demonstrates its effectiveness in detecting biases and even disclaiming them, showcasing its broad applicability for model diagnosis.
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- 2024
4. On the use of field RR Lyrae as Galactic probes VII. light curve templates in the LSST photometric system
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Braga, V. F., Monelli, M., Dall'Ora, M., Mullen, J. P., Molinaro, R., Marconi, M., Szabó, R., and Gallart, C.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The \textit{Vera C. Rubin} Observatory will start operations in 2025. During the first two years, too few visits per target per band will be available, meaning that mean magnitude measurements of variable stars will not be precise and thus, standard candles like RR Lyrae (RRL) will not be usable. Light curve templates (LCTs) can be adopted to estimate the mean magnitude of a variable star with few magnitude measurements, provided that their period (plus amplitude and reference epoch, depending on how the LCT is applied) is known. LSST will provide precise RRL periods within the first six months, allowing to exploit RRLs if LCTs were available. We aim to build LCTs in the LSST bands to enhance the early science with LSST. Using them will provide a 1-2 years advantage with respect to a classical approach, concerning distance measurements. We collected $gri$-band data from the ZTF survey and $z$-band data from DECam to build the LCTs of RRLs. We also adopted synthetic $griz$-band data in the LSST system from pulsation models, plus SDSS, \gaia and OGLE photometry, inspecting the light amplitude ratios in different photometric systems to provide useful conversions to apply the LCTs. We have built LCTs of RRLs in the $griz$ bands of the LSST photometric system; for the $z$ band, we could build only fundamental-mode RRL LCTs. We quantitatively demonstrated that LCTs built with ZTF and DECam data can be adopted on the LSST photometric system. LCTs will decrease by a factor of at least two the uncertainty on distance estimates of RRLs, with respect to a simple average of the available measurements. Finally, within our tests, we have found a brand new behavior of amplitude ratios in the Large Magellanic Cloud., Comment: Accepted for publication in A&A
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- 2024
5. When LLMs Play the Telephone Game: Cumulative Changes and Attractors in Iterated Cultural Transmissions
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Perez, Jérémy, Léger, Corentin, Kovač, Grgur, Colas, Cédric, Molinaro, Gaia, Derex, Maxime, Oudeyer, Pierre-Yves, and Moulin-Frier, Clément
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Physics - Physics and Society ,Computer Science - Artificial Intelligence ,Computer Science - Multiagent Systems ,68T50 ,I.2.7 - Abstract
As large language models (LLMs) start interacting with each other and generating an increasing amount of text online, it becomes crucial to better understand how information is transformed as it passes from one LLM to the next. While significant research has examined individual LLM behaviors, existing studies have largely overlooked the collective behaviors and information distortions arising from iterated LLM interactions. Small biases, negligible at the single output level, risk being amplified in iterated interactions, potentially leading the content to evolve towards attractor states. In a series of telephone game experiments, we apply a transmission chain design borrowed from the human cultural evolution literature: LLM agents iteratively receive, produce, and transmit texts from the previous to the next agent in the chain. By tracking the evolution of text toxicity, positivity, difficulty, and length across transmission chains, we uncover the existence of biases and attractors, and study their dependence on the initial text, the instructions, language model, and model size. For instance, we find that more open-ended instructions lead to stronger attraction effects compared to more constrained tasks. We also find that different text properties display different sensitivity to attraction effects, with toxicity leading to stronger attractors than length. These findings highlight the importance of accounting for multi-step transmission dynamics and represent a first step towards a more comprehensive understanding of LLM cultural dynamics., Comment: Code available at https://github.com/jeremyperez2/TelephoneGameLLM. Companion website with a Data Explorer tool at https://sites.google.com/view/telephone-game-llm
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- 2024
6. Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody.
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Beernink, Peter, Di Carluccio, Cristina, Marchetti, Roberta, Cerofolini, Linda, Carillo, Sara, Cangiano, Alessandro, Cowieson, Nathan, Bones, Jonathan, Molinaro, Antonio, Paduano, Luigi, Fragai, Marco, Beernink, Benjamin, Gulati, Sunita, Shaughnessy, Jutamas, Rice, Peter, Ram, Sanjay, and Silipo, Alba
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The spread of multidrug-resistant strains of Neisseria gonorrhoeae, the etiologic agent of gonorrhea, represents a global health emergency. Therefore, the development of a safe and effective vaccine against gonorrhea is urgently needed. In previous studies, murine monoclonal antibody (mAb) 2C7 was raised against gonococcal lipooligosaccharide (LOS). mAb 2C7 elicits complement-dependent bactericidal activity against gonococci, and its glycan epitope is expressed by almost every clinical isolate. Furthermore, we identified a peptide, cyclic peptide 2 (CP2) that mimicked the 2C7 LOS epitope, elicited bactericidal antibodies in mice, and actively protected in a mouse vaginal colonization model. In this study, we performed structural analyses of mAb 2C7 and its complex with the CP2 peptide by X-ray crystallography, NMR spectroscopy, and molecular dynamics (MD) simulations. The crystal structure of Fab 2C7 bound to CP2 showed that the peptide adopted a beta-hairpin conformation and bound the Fab primarily through hydrophobic interactions. We employed NMR spectroscopy and MD simulations to map the 2C7 epitope and identify the bioactive conformation of CP2. We also used small-angle X-ray scattering (SAXS) and native mass spectrometry to obtain further information about the shape and assembly state of the complex. Collectively, our new structural information suggests strategies for humanizing mAb 2C7 as a therapeutic against gonococcal infection and for optimizing peptide CP2 as a vaccine antigen.
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- 2024
7. Supermodular Approximation of Norms and Applications
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Kesselheim, Thomas, Molinaro, Marco, and Singla, Sahil
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Computer Science - Data Structures and Algorithms - Abstract
Many classical problems in theoretical computer science involve norm, even if implicitly; for example, both XOS functions and downward-closed sets are equivalent to some norms. The last decade has seen a lot of interest in designing algorithms beyond the standard $\ell_p$ norms $\|\cdot \|_p$. Despite notable advancements, many existing methods remain tailored to specific problems, leaving a broader applicability to general norms less understood. This paper investigates the intrinsic properties of $\ell_p$ norms that facilitate their widespread use and seeks to abstract these qualities to a more general setting. We identify supermodularity -- often reserved for combinatorial set functions and characterized by monotone gradients -- as a defining feature beneficial for $ \|\cdot\|_p^p$. We introduce the notion of $p$-supermodularity for norms, asserting that a norm is $p$-supermodular if its $p^{th}$ power function exhibits supermodularity. The association of supermodularity with norms offers a new lens through which to view and construct algorithms. Our work demonstrates that for a large class of problems $p$-supermodularity is a sufficient criterion for developing good algorithms. This is either by reframing existing algorithms for problems like Online Load-Balancing and Bandits with Knapsacks through a supermodular lens, or by introducing novel analyses for problems such as Online Covering, Online Packing, and Stochastic Probing. Moreover, we prove that every symmetric norm can be approximated by a $p$-supermodular norm. Together, these recover and extend several results from the literature, and support $p$-supermodularity as a unified theoretical framework for optimization challenges centered around norm-related problems., Comment: Full version of STOC 2024 paper
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- 2024
8. Light curve's recovery with Rubin-LSST: II. UnVEiling the darknesS of The gAlactic buLgE (VESTALE) with RR Lyrae
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Di Criscienzo, M., Leccia, S., Braga, V., Musella, I., Bono, G., Dall'Ora, M., Fiorentino, G., Marconi, M., Molinaro, R., Ripepi, V., Girardi, L., Mazzi, A., Pastorelli, G., Trabucchi, M., Matsunaga, N., Monelli, M., Saha, A., Vivas, K., and Sanchez, R. Zanmar
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
This work is part of VESTALE, a project initiated within the Rubin-LSST Cadence Strategy Optimization Process . Its goal is to explore the potential of Rubin-LSST observations aimed at the Galaxy's bulge (Bulge) for studying RR Lyrae stars (RRL). Observation and analysis of RR Lyrae stars in the Bulge are crucial for tracing the old population of the central part of our galaxy and reconstructing the history of Bulge formation. Based on observations conducted with CTIO/DECam by Saha et al. 2019 towards the Baade Window, our simulations demonstrate that early Rubin-LSST observations will enable the recovery of RR Lyrae light curves at Galactic center distances with sufficient precision. This will allow us to utilize theoretical relations from Marconi et al. 2022 to determine their distances and/or metallicity, following the REDIME algorithm introduced in Bono et al. 2019. We show how reddening and crowding affect our simulations and highlight the importance of considering these effects when deriving pulsation parameters (luminosity amplitudes, mean magnitudes) based on the light curves especially if the goal is to explore the opposite side of the Bulge through the observation of its RRL. The simulations discussed in this investigation were conducted to support the SCOC's decision to observe this important sky region since it has only recently been decided to include part of the Bulge as a target within the LSST main survey., Comment: Accepted for publication in ApJS. 12 pages and 6 figures
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- 2024
9. A Universal Transfer Theorem for Convex Optimization Algorithms Using Inexact First-order Oracles
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Kerger, Phillip, Molinaro, Marco, Jiang, Hongyi, and Basu, Amitabh
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Mathematics - Optimization and Control - Abstract
Given any algorithm for convex optimization that uses exact first-order information (i.e., function values and subgradients), we show how to use such an algorithm to solve the problem with access to inexact first-order information. This is done in a ``black-box'' manner without knowledge of the internal workings of the algorithm. This complements previous work that considers the performance of specific algorithms like (accelerated) gradient descent with inexact information. In particular, our results apply to a wider range of algorithms beyond variants of gradient descent, e.g., projection-free methods, cutting-plane methods, or any other first-order methods formulated in the future. Further, they also apply to algorithms that handle structured nonconvexities like mixed-integer decision variables., Comment: 15 pages, 1 figure
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- 2024
10. GPU-accelerated Higher Representations of Wilson Fermions with HiRep
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Martins, Sofie, Kjellgren, Erik, Molinaro, Emiliano, Pica, Claudio, and Rago, Antonio
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High Energy Physics - Lattice ,Physics - Computational Physics - Abstract
We are improving one of the available lattice software packages HiRep by adding GPU acceleration supporting highly-optimized simulations on both NVIDIA and AMD GPUs. HiRep allows lattice simulations of theories with fermions in higher representations and a variable number of colors in the gauge group. The development is accompanied by an overall software quality improvement in the build system, testing, and documentation, adding features for both CPUs and GPUs. The software is available under https://github.com/claudiopica/HiRep, Comment: Proceedings for the EuroPLEx Final Conference, 11-15 September 2023, Humboldt University of Berlin
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- 2024
11. Poseidon: Efficient Foundation Models for PDEs
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Herde, Maximilian, Raonić, Bogdan, Rohner, Tobias, Käppeli, Roger, Molinaro, Roberto, de Bézenac, Emmanuel, and Mishra, Siddhartha
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Computer Science - Machine Learning - Abstract
We introduce Poseidon, a foundation model for learning the solution operators of PDEs. It is based on a multiscale operator transformer, with time-conditioned layer norms that enable continuous-in-time evaluations. A novel training strategy leveraging the semi-group property of time-dependent PDEs to allow for significant scaling-up of the training data is also proposed. Poseidon is pretrained on a diverse, large scale dataset for the governing equations of fluid dynamics. It is then evaluated on a suite of 15 challenging downstream tasks that include a wide variety of PDE types and operators. We show that Poseidon exhibits excellent performance across the board by outperforming baselines significantly, both in terms of sample efficiency and accuracy. Poseidon also generalizes very well to new physics that is not seen during pretraining. Moreover, Poseidon scales with respect to model and data size, both for pretraining and for downstream tasks. Taken together, our results showcase the surprising ability of Poseidon to learn effective representations from a very small set of PDEs during pretraining in order to generalize well to unseen and unrelated PDEs downstream, demonstrating its potential as an effective, general purpose PDE foundation model. Finally, the Poseidon model as well as underlying pretraining and downstream datasets are open sourced, with code being available at https://github.com/camlab-ethz/poseidon and pretrained models and datasets at https://huggingface.co/camlab-ethz.
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- 2024
12. The GAPS programme at TNG. LVII. TOI-5076b: A warm sub-Neptune planet orbiting a thin-to-thick-disk transition star in a wide binary system
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Montalto, M., Greco, N., Biazzo, K., Desidera, S., Andreuzzi, G., Bieryla, A., Bignamini, A., Bonomo, A. S., Briceño, C., Cabona, L., Cosentino, R., Damasso, M., Fiorenzano, A., Fong, W., Goeke, B., Hesse, K. M., Kostov, V. B., Lanza, A. F., Latham, D. W., Law, N., Mancini, L., Maggio, A., Molinaro, M., Mann, A. W., Mantovan, G., Naponiello, L., Nardiello, D., Nascimbeni, V., Pagano, I., Pedani, M., Safonov, B. S., Scandariato, G., Seager, S., Singh, V., Sozzetti, A., Strakhov, I. A., Winn, J. N., Ziegler, C., and Zingales, T.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims. We report the confirmation of a new transiting exoplanet orbiting the star TOI-5076. Methods. We present our vetting procedure and follow-up observations which led to the confirmation of the exoplanet TOI-5076b. In particular, we employed high-precision {\it TESS} photometry, high-angular-resolution imaging from several telescopes, and high-precision radial velocities from HARPS-N. Results. From the HARPS-N spectroscopy, we determined the spectroscopic parameters of the host star: T$\rm_{eff}$=(5070$\pm$143) K, log~g=(4.6$\pm$0.3), [Fe/H]=(+0.20$\pm$0.08), and [$\alpha$/Fe]=0.05$\pm$0.06. The transiting planet is a warm sub-Neptune with a mass m$\rm_p=$(16$\pm$2) M$\rm_{\oplus}$, a radius r$\rm_p=$(3.2$\pm$0.1)~R$\rm_{\oplus}$ yielding a density $\rho_p$=(2.8$\pm$0.5) g cm$^{-3}$. It revolves around its star approximately every 23.445 days. Conclusions. The host star is a metal-rich, K2V dwarf, located at about 82 pc from the Sun with a radius of R$_{\star}$=(0.78$\pm$0.01) R$_{\odot}$ and a mass of M$_{\star}$=(0.80$\pm$0.07) M$_{\odot}$. It forms a common proper motion pair with an M-dwarf companion star located at a projected separation of 2178 au. The chemical analysis of the host-star and the Galactic-space velocities indicate that TOI-5076 belongs to the old population of thin-to-thick-disk transition stars. The density of TOI-5076b suggests the presence of a large fraction by volume of volatiles overlying a massive core. We found that a circular orbit solution is marginally favored with respect to an eccentric orbit solution for TOI-5076b., Comment: Accepted by Astronomy & Astrophysics: 15 pages, 19 figures, 4 tables
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- 2024
13. Cepheid Metallicity in the Leavitt Law (C- MetaLL) survey: VI: Radial abundance gradients of 29 chemical species in the Milky Way Disk
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Trentin, E., Catanzaro, G., Ripepi, V., Alonso-Santiago, J., Molinaro, R., Storm, J., De Somma, G., Marconi, M., Bhardwaj, A., Gatto, M., Musella, I., and Testa, V.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Classical Cepheids (DCEPs) are crucial for calibrating the extragalactic distance ladder, ultimately enabling the determination of the Hubble constant through the PL and PW relations they exhibit. Hence it's vital to understand how the PL and PW relations depend on metallicity. This is the purpose of the C-MetaLL survey within which this work is situated. DCEPs are also very important tracers of the young populations placed along the Galactic disc. We aim to enlarge the sample of DCEPs with accurate abundances from high-resolution spectroscopy. Our goal is to extend the range of measured metallicities towards the metal-poor regime to better cover the parameter space. We observed objects in a wide range of Galactocentric radii, allowing us to study in detail the abundance gradients present in the Galactic disc. We present the results of the analysis of 331 spectra obtained for 180 individual DCEPs with a variety of high-resolution spectrographs. We derived accurate atmospheric parameters, radial velocities, and abundances for up to 29 different species. The iron abundances range between 0.5 and -1 dex with a rather homogeneous distribution in metallicity. The sample presented in this paper was complemented with that already published in the context of the C-MetaLL survey, resulting in a total of 292 pulsators whose spectra have been analysed in a homogeneous way. These data were used to study the abundance gradients of the Galactic disc in a range of Galactocentric radii spanning the range 5-20 kpc. For most of the elements we found a clear negative gradient, with a slope of -0.071\pm0.003 dex kpc^-1 for [Fe/H] case. Through a qualitative fit with the Galactic spiral arms we shown how our farthest targets (R_GC>10 kpc) trace both the Outer and OSC arms. The homogeneity of the sample will be of pivotal importance for the study of the metallicity dependance of the DCEP PL relations., Comment: 16 pages, 16 figures, 4 tables, accepted to be published in A&A
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- 2024
14. Phase-Field Modeling of Fracture with Physics-Informed Deep Learning
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Manav, M., Molinaro, R., Mishra, S., and De Lorenzis, L.
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Physics - Applied Physics - Abstract
We explore the potential of the deep Ritz method to learn complex fracture processes such as quasistatic crack nucleation, propagation, kinking, branching, and coalescence within the unified variational framework of phase-field modeling of brittle fracture. We elucidate the challenges related to the neural-network-based approximation of the energy landscape, and the ability of an optimization approach to reach the correct energy minimum, and we discuss the choices in the construction and training of the neural network which prove to be critical to accurately and efficiently capture all the relevant fracture phenomena. The developed method is applied to several benchmark problems and the results are shown to be in qualitative and quantitative agreement with the finite element solution. The robustness of the approach is tested by using neural networks with different initializations., Comment: 43 pages, 29 figures
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- 2024
15. Discovery of a dormant 33 solar-mass black hole in pre-release Gaia astrometry
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Gaia Collaboration, Panuzzo, P., Mazeh, T., Arenou, F., Holl, B., Caffau, E., Jorissen, A., Babusiaux, C., Gavras, P., Sahlmann, J., Bastian, U., Wyrzykowski, Ł., Eyer, L., Leclerc, N., Bauchet, N., Bombrun, A., Mowlavi, N., Seabroke, G. M., Teyssier, D., Balbinot, E., Helmi, A., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Barbier, A., Biermann, M., Creevey, O. L., Ducourant, C., Evans, D. W., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Nicolas, C., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Aerts, C., Bailer-Jones, C. A. L., Cropper, M., Drimmel, R., Jansen, F., Katz, D., Lattanzi, M. G., Soubiran, C., Thévenin, F., van Leeuwen, F., Andrae, R., Audard, M., Bakker, J., Blomme, R., Castañeda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Frémat, Y., Galluccio, L., Guerrier, A., Heiter, U., Masana, E., Messineo, R., Nienartowicz, K., Pailler, F., Riclet, F., Roux, W., Sordo, R., Gracia-Abril, G., Portell, J., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cacciari, C., Cánovas, H., Carrasco, J. M., Carry, B., Cellino, A., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Delchambre, L., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., García-Lario, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernández, J., Hestroffer, D., Hodgkin, S. T., Jamal, S., de Fombelle, G. Jevardat, Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Ahmed, S., Altavilla, G., Álvarez, M. A., Anders, F., Anderson, R. I., Varela, E. Anglada, Antoja, T., Baig, S., Baines, D., Baker, S. G., Balaguer-Núñez, L., Balog, Z., Barache, C., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bassilana, J. -L., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blanco-Cuaresma, S., Bland-Hawthorn, J., Blazere, A., Boch, T., Bossini, D., Bouquillon, S., Bragaglia, A., Braine, J., Bratsolis, E., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Camut, A., Cancelliere, R., Cantat-Gaudin, T., Guilarte, D. Capilla, Carballo, R., Carlucci, T., Carnerero, M. I., Carretero, J., Carton, S., Casamiquela, L., Casey, A., Castellani, M., Castro-Ginard, A., Ceraj, L., Cesare, V., Charlot, P., Chaudet, C., Chemin, L., Chiavassa, A., Chornay, N., Chosson, D., Cooper, W. J., Cornez, T., Cowell, S., Crosta, M., Crowley, C., Reyes, M. Cruz, Dafonte, C., Ponte, M. Dal, David, M., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Delisle, J. -B., Demouchy, C., Denis, E., Dharmawardena, T. E., Di Giacomo, F., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Enke, H., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fouron, C., Fragkoudi, F., Gai, M., Galinier, M., Garcia-Serrano, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomboc, A., Gomez, A., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Kaczmarek, Z., Kervella, P., Khanna, S., Kontizas, M., Kordopatis, G., Korn, A. J., Kóspál, Á, Kostrzewa-Rutkowska, Z., Kruszyńska, K., Kun, M., Lambert, S., Lanza, A. F., Lebreton, Y., Lebzelter, T., Leccia, S., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Livanou, E., Lobel, A., López-Miralles, J., Loup, C., Madarász, M., Mahy, L., Mann, R. G., Manteiga, M., Marinoni, S., Marcellino, C. P., Marshall, D. J., Mascarenhas, D., Marchant, J. M., Lozano, J. Martín, Masip, A., Marconi, M., Pina, D. Marín, Polo, L. Martin, Martín-Fleitas, J. M., Mastrobuono-Battisti, A., McMillan, P. J., Meichsner, J. G. Marton, Merc, J., Messina, S., Millar, N. R., Mints, A., Mohamed, D., Molina, D., Molinaro, R., Monguió, M., Montegriffo, P., Monti, L., Mora, A., Morbidelli, R., Morris, D., Mudimadugula, R., Muraveva, T., Musella, I., Nagy, Z., Nardetto, N., Navarrete, C., Oh, S., Ordenovic, C., Orenstein, O., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Pawlak, M., Penttilä, A., Pesciullesi, P., Pinamonti, M., Plachy, E., Planquart, L., Plum, G., Poggio, E., Pourbaix, D., Price-Whelan, A. M., Pulone, L., Rabin, V., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robert, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Sellés, A. Sagristà, Sanna, N., Santoveña, R., Sarasso, M., Sarmiento, M. H., Riera, C. Sarrate, Sciacca, E., Ségransan, D., Semczuk, M., Shahaf, S., Siebert, A., Slezak18, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tepper-Garcia, T., Thuillot, W., Tolomei, L., Tonello, N., Torra, F., Elipe, G. Torralba, Trabucchi, M., Trentin, E., Tsantaki, M., Turon, C., Ulla, A., Unger, N., Valtchanov, I., Vanel, O., Vecchiato, A., Vicente, D., Villar, E., Weiler, M., Zhao, H., Zorec, J., Zucker, S., Župić, A., and Zwitter, T.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Gravitational waves from black-hole merging events have revealed a population of extra-galactic BHs residing in short-period binaries with masses that are higher than expected based on most stellar evolution models - and also higher than known stellar-origin black holes in our Galaxy. It has been proposed that those high-mass BHs are the remnants of massive metal-poor stars. Gaia astrometry is expected to uncover many Galactic wide-binary systems containing dormant BHs, which may not have been detected before. The study of this population will provide new information on the BH-mass distribution in binaries and shed light on their formation mechanisms and progenitors. As part of the validation efforts in preparation for the fourth Gaia data release (DR4), we analysed the preliminary astrometric binary solutions, obtained by the Gaia Non-Single Star pipeline, to verify their significance and to minimise false-detection rates in high-mass-function orbital solutions. The astrometric binary solution of one source, Gaia BH3, implies the presence of a 32.70 \pm 0.82 M\odot BH in a binary system with a period of 11.6 yr. Gaia radial velocities independently validate the astrometric orbit. Broad-band photometric and spectroscopic data show that the visible component is an old, very metal-poor giant of the Galactic halo, at a distance of 590 pc. The BH in the Gaia BH3 system is more massive than any other Galactic stellar-origin BH known thus far. The low metallicity of the star companion supports the scenario that metal-poor massive stars are progenitors of the high-mass BHs detected by gravitational-wave telescopes. The Galactic orbit of the system and its metallicity indicate that it might belong to the Sequoia halo substructure. Alternatively, and more plausibly, it could belong to the ED-2 stream, which likely originated from a globular cluster that had been disrupted by the Milky Way., Comment: 23 pages, accepted fro publication in A&A Letters. New version with small fixes
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- 2024
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16. The GAPS Programme at TNG. XXX: Characterization of the low-density gas giant HAT-P-67 b with GIARPS
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Sicilia, D., Scandariato, G., Guilluy, G., Esposito, M., Borsa, F., Stangret, M., Di Maio, C., Lanza, A. F., Bonomo, A. S., Desidera, S., Fossati, L., Nardiello, D., Sozzetti, A., Malavolta, L., Nascimbeni, V., Rainer, M., D'Arpa, M. C., Mancini, L., Singh, V., Zingales, T., Affer, L., Bignamini, A., Claudi, R., Colombo, S., Cosentino, R., Ghedina, A., Micela, G., Molinari, E., Molinaro, M., Pagano, I., and Piotto, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
HAT-P-67 b is one of the lowest-density gas giants known to date, making it an excellent target for atmospheric characterization through the transmission spectroscopy technique. In the framework of the GAPS large programme, we collected four transit events, with the aim of studying the exoplanet atmosphere and deriving the orbital projected obliquity. We exploited the high-precision GIARPS observing mode of the TNG, along with additional archival TESS photometry, to explore the activity level of the host star. We performed transmission spectroscopy, both in the VIS and in the nIR wavelength range, and analysed the RML effect both fitting the RVs and the Doppler shadow. Based on the TESS photometry, we redetermined the transit parameters of HAT-P-67 b. By modelling the RML effect, we derived a sky-projected obliquity of ($2.2\pm0.4$){\deg} indicating an aligned planetary orbit. The chromospheric activity index $\log\,R^{\prime}_{\rm HK}$, the CCF profile, and the variability in the transmission spectrum of the H$\alpha$ line suggest that the host star shows signatures of stellar activity and/or pulsations. We found no evidence of atomic or molecular species in the VIS transmission spectra, with the exception of pseudo-signals corresponding to Cr I, Fe I, H$\alpha$, Na I, and Ti I. In the nIR range, we found an absorption signal of the He I triplet of 5.56$^{+0.29}_{-0.30}$%(19.0$\sigma$), corresponding to an effective planetary radius of $\sim$3$R_p$ (where $R_p\sim$2$R_J$) which extends beyond the planet's Roche Lobe radius. Owing to the stellar variability, together with the high uncertainty of the model, we could not confirm the planetary origin of the signals found in the optical transmission spectrum. On the other hand, we confirmed previous detections of the infrared He I triplet, providing a 19.0$\sigma$ detection. Our finding indicates that the planet's atmosphere is evaporating., Comment: Accepted for publication in A&A
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- 2024
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17. “De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade
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Hadad, Sara, Gupta, Rohit, Oberheim Bush, Nancy Ann, Taylor, Jennie W, Villanueva-Meyer, Javier E, Young, Jacob S, Wu, Jasper, Ravindranathan, Ajay, Zhang, Yalan, Warrier, Gayathri, McCoy, Lucie, Shai, Anny, Pekmezci, Melike, Perry, Arie, Bollen, Andrew W, Phillips, Joanna J, Braunstein, Steve E, Raleigh, David R, Theodosopoulos, Philip, Aghi, Manish K, Chang, Edward F, Hervey-Jumper, Shawn L, Costello, Joseph F, de Groot, John, Butowski, Nicholas A, Clarke, Jennifer L, Chang, Susan M, Berger, Mitchel S, Molinaro, Annette M, and Solomon, David A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Brain Cancer ,Cancer ,Precision Medicine ,Brain Disorders ,Genetics ,Human Genome ,Clinical Research ,Cancer Genomics ,Neurosciences ,Immunotherapy ,Orphan Drug ,Rare Diseases ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Adult ,Humans ,Child ,Middle Aged ,Aged ,Glioblastoma ,Immune Checkpoint Inhibitors ,Homozygote ,Prospective Studies ,Brain Neoplasms ,Sequence Deletion ,Mutation ,Isocitrate Dehydrogenase ,Giant cell glioblastoma ,Hypermutation ,Ultrahypermutation ,Mismatch repair deficiency ,POLE ,Lynch syndrome ,Immune checkpoint blockade ,Molecular neuropathology ,Molecular neuro-oncology ,Neurology & Neurosurgery - Abstract
Glioblastoma is a clinically and molecularly heterogeneous disease, and new predictive biomarkers are needed to identify those patients most likely to respond to specific treatments. Through prospective genomic profiling of 459 consecutive primary treatment-naïve IDH-wildtype glioblastomas in adults, we identified a unique subgroup (2%, 9/459) defined by somatic hypermutation and DNA replication repair deficiency due to biallelic inactivation of a canonical mismatch repair gene. The deleterious mutations in mismatch repair genes were often present in the germline in the heterozygous state with somatic inactivation of the remaining allele, consistent with glioblastomas arising due to underlying Lynch syndrome. A subset of tumors had accompanying proofreading domain mutations in the DNA polymerase POLE and resultant "ultrahypermutation". The median age at diagnosis was 50 years (range 27-78), compared with 63 years for the other 450 patients with conventional glioblastoma (p
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- 2024
18. Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC.
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Plasschaert, Sabine, Molinaro, Annette, Koschmann, Carl, Nazarian, Javad, Mueller, Sabine, Kline, Cassie, Franson, Andrea, van der Lugt, Jasper, Prados, Michael, and Waszak, Sebastian
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ONC201 ,clinical trials ,diffuse midline glioma ,paxalisib ,pediatric neuro-oncology ,Humans ,Glioma ,Brain Neoplasms ,Child ,Young Adult ,Adolescent ,Antineoplastic Combined Chemotherapy Protocols ,Pyrimidines ,Adult ,Female ,Research Design ,Prognosis ,Male ,Quality of Life - Abstract
Background Diffuse midline glioma (DMG) is a devastating pediatric brain tumor unresponsive to hundreds of clinical trials. Approximately 80% of DMGs harbor H3K27M oncohistones, which reprogram the epigenome to increase the metabolic profile of the tumor cells. Methods We have previously shown preclinical efficacy of targeting both oxidative phosphorylation and glycolysis through treatment with ONC201, which activates the mitochondrial protease ClpP, and paxalisib, which inhibits PI3K/mTOR, respectively. Results ONC201 and paxalisib combination treatment aimed at inducing metabolic distress led to the design of the first DMG-specific platform trial PNOC022 (NCT05009992). Conclusions Here, we expand on the PNOC022 rationale and discuss various considerations, including liquid biome, microbiome, and genomic biomarkers, quality-of-life endpoints, and novel imaging modalities, such that we offer direction on future clinical trials in DMG.
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- 2024
19. The Hertzsprung progression of Classical Cepheids in the Gaia era
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Marconi, Marcella, De Somma, Giulia, Molinaro, Roberto, Bhardwaj, Anupam, Ripepi, Vincenzo, Musella, Ilaria, Sicignano, Teresa, trentin, Erasmo, and Leccia, silvio
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Astrophysics - Solar and Stellar Astrophysics - Abstract
A new fine grid of nonlinear convective pulsation models for the so-called "bump Cepheids" is presented to investigate the Hertzprung progression (HP) phenomenon shown by their light and radial pulsation velocity curves. The period corresponding to the center of the HP is investigated as a function of various model assumptions, such as the efficiency of super-adiabatic convection, the mass-luminosity relation, and the metal and helium abundances. The assumed mass-luminosity relation is found to significantly affect the phenomenon but variations in the chemical composition as well as in the stellar mass (at fixed mass-luminosity relation) also play a key role in determining the value of the HP center period. Finally, the predictive capability of the presented theoretical scenario is tested against observed light curves of bump Cepheids in the ESA Gaia database, also considering the variation of the pulsation amplitudes and of the Fourier parameters $R_{21}$ and $\Phi_{21}$ with the pulsation period. A qualitative agreement between theory and observations is found for what concerns the evolution of the light curve morphology as the period moves across the HP center, as well for the pattern in period-amplitude, period-$R21$ and period-$\Phi_{21}$ planes. A larger sample of observed Cepheids with accurate light curves and metallicities is required in order to derive more quantitative conclusions., Comment: Accepted for publication on MNRAS
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- 2024
20. The GAPS Programme at TNG LV. Multiple molecular species in the atmosphere of HAT-P-11 b and review of the HAT-P-11 planetary system
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Basilicata, M., Giacobbe, P., Bonomo, A. S., Scandariato, G., Brogi, M., Singh, V., Di Paola, A., Mancini, L., Sozzetti, A., Lanza, A. F., Cubillos, P. E., Damasso, M., Desidera, S., Biazzo, K., Bignamini, A., Borsa, F., Cabona, L., Carleo, I., Ghedina, A., Guilluy, G., Maggio, A., Mainella, G., Micela, G., Molinari, E., Molinaro, M., Nardiello, D., Pedani, M., Pino, L., Poretti, E., Southworth, J., Stangret, M., and Turrini, D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The atmospheric characterisation of hot and warm Neptune-size exoplanets is challenging due to their small radius and atmospheric scale height. The warm-Neptune HAT-P-11b is a remarkable target for such characterisation due to the large brightness of its host star (V=9.46 mag; H=7.13 mag). The aims of this work are to review the main physical and architectural properties of the HAT-P-11 planetary system, and to probe the presence of 8 molecular species in the atmosphere of HAT-P-11b at high spectral resolution in the near-infrared. The planetary system was reviewed by analysing transits and occultations of HAT-P-11b from the Kepler data set as well as HIRES at Keck archival radial-velocity (RV) data. We modelled the latter with Gaussian-process regression and a combined quasi-periodic and squared-exponential kernel to account for stellar variations on both (short-term) rotation and (long-term) activity-cycle timescales. In order to probe the atmospheric composition of HAT-P-11b, we observed 4 transits of this target with GIANO-B at TNG. We find that the long-period ($P\sim9.3$ years) RV signal previously attributed to planet HAT-P-11c is more likely due to the stellar magnetic activity cycle. Nonetheless, the Hipparcos-Gaia difference in the proper-motion anomaly suggests that an outer-bound companion might still exist. For HAT-P-11b, we measure a radius $R_{\rm p}=0.4466\pm0.0059\,R_{\rm J}$, a mass $M_{\rm p}=0.0787\pm0.0048\,M_{\rm J}$, and an eccentricity $e=0.2577^{+0.0033}_{-0.0025}$, in accordance with values in the literature. Probing its atmosphere, we detect $NH_3$ (S/N$=5.3$, significance$=5.0\sigma$) and confirm the presence of $H_2O$ (S/N$=5.1$, significance$=3.4\sigma$). We also tentatively detect the signal of $CO_2$ (S/N$=3.0$, significance$=3.2\sigma$) and $CH_4$ (S/N$=4.8$, significance$=2.6\sigma$), whose presence need to be confirmed by further observations., Comment: 25 pages, 19 figures, accepted for publication in Astronomy & Astrophysics (A&A) journal. Version corrected by the language editor, title edited
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- 2024
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21. Classical Cepheid Pulsation properties in the Rubin-LSST filters
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De Somma, Giulia, Marconi, Marcella, Cassisi, Santi, Molinaro, Roberto, Bhardwaj, Anupam, Ripepi, Vincenzo, Musella, Ilaria, Pietrinferni, Adriano, Sicignano, Teresa, Trentin, Erasmo, and Leccia, Silvio
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Homogeneous multi-wavelength observations of classical Cepheids from the forthcoming Rubin-LSST have the potential to significantly contribute to our understanding of the evolutionary and pulsation properties of these pulsating stars. Updated pulsation models for Classical Cepheid stars have been computed under various assumptions about chemical compositions, including relatively low metallicity ($Z$ = $0.004$ with $Y$ =$0.25$ and $Z$=$0.008$ with $Y$ =$0.25$), solar metallicity ($Z$=$0.02$ with $Y$=$0.28$), and supersolar metallicity environments ($Z$ = $0.03$ with $Y$ = $0.28$). From the predicted periods, intensity-weighted mean magnitudes, and colors, we have derived the first theoretical pulsation relations in the Rubin-LSST filters (ugrizy), including period-luminosity-color, period-Wesenheit, and period-age-color relations. We find that the coefficients of these relations are almost insensitive to the efficiency of superadiabatic convection but are significantly affected by the assumption of the mass-luminosity relation and the adopted chemical composition. Metal-dependent versions of these relations are also derived, representing valuable tools for individual distance determinations and correction for metallicity effects on the cosmic distance scale., Comment: 23 pages, 6 figures, and 11 tables; accepted for publication in MNRAS
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- 2024
22. Non-Monotonicity of Branching Rules with respect to Linear Relaxations
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Shah, Prachi, Dey, Santanu S., and Molinaro, Marco
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Mathematics - Optimization and Control - Abstract
Modern mixed-integer programming solvers use the branch-and-cut framework, where cutting planes are added to improve the tightness of the linear programming (LP) relaxation, with the expectation that the tighter formulation would produce smaller branch-and-bound trees. In this work, we consider the question of whether adding cuts will always lead to smaller trees for a given fixed branching rule. We formally call such a property of a branching rule monotonicity. We prove that any branching rule which exclusively branches on fractional variables in the LP solution is non-monotonic. Moreover, we present a family of instances where adding a single cut leads to an exponential increase in the size of full strong branching trees, despite improving the LP bound. Finally, we empirically attempt to estimate the prevalence of non-monotonicity in practice while using full strong branching. We consider randomly generated multi-dimensional knapsacks tightened by cover cuts as well as instances from the MIPLIB 2017 benchmark set for the computational experiments. Our main insight from these experiments is that if the gap closed by cuts is small, change in tree size is difficult to predict, and often increases, possibly due to inherent non-monotonicity. However, when a sufficiently large gap is closed, a significant decrease in tree size may be expected.
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- 2024
23. The VMC Survey -- L. Type II Cepheids in the Magellanic Clouds
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Sicignano, Teresa, Ripepi, Vincenzo, Marconi, Marcella, Molinaro, Roberto, Bhardwaj, Anupam, Cioni, Maria-Rosa L, de Grijs, Richard, Storm, Jesper, Groenewegen, Martin A T, Ivanov, Valentin D, van Loon, Jacco Th, and De Somma, Giulia
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Type II Cepheids (T2C) are less frequently used counterparts of classical Cepheids which provide the primary calibration of the distance ladder for measuring $H_0$ in the local Universe. In the era of the Hubble Tension, T2C variables with the RR Lyrae stars (RRL) and the tip of the red giant branch (TRGB) can potentially provide classical Cepheid independent calibration of the cosmic distance ladder. Our goal is to provide an absolute calibration of the Period-Luminosity, Period-Luminosity-Color and Period-Wesenheit relations(PL,PLC and PW) of T2Cs in the Large Magellanic Cloud (LMC). We exploited time-series photometry in the near-infrared (NIR) bands for a sample of more than 320 T2Cs in the Magellanic Clouds (MC). These observations were acquired during 2009-2018 in the context of the VMC ESO public survey (The VISTA near-infrared YJKs survey of the Magellanic System). The NIR photometry was supplemented with well-sampled optical light curves and accurate pulsation periods from the OGLE IV survey and the Gaia mission. We used the best-quality NIR light curves to generate custom templates for modelling sparsely sampled light curves in YJKs bands; in turn, we derived accurate and precise intensity-averaged mean magnitudes and pulsation amplitudes of 339 T2Cs in the MC. We used optical and NIR mean magnitudes to derive PL/PLC/PW relations for T2Cs in multiple bands, which were calibrated with the geometric distance to the LMC and with the Gaia parallaxes. We used our new empirical calibrations of PL/PW relations to obtain distances to 22 T2C-host Galactic globular clusters, which were found to be systematically smaller by 0.1 mag and 0.03-0.06 mag compared with the literature. A better agreement is found between our distances and those based on RRLs in globular clusters, providing strong support for using these population II stars with the TRGB for future distance scale studies.
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- 2024
24. Cepheid Metallicity in the Leavitt Law (C-MetaLL) Survey. V. New multiband (grizJHKs) Cepheid light curves and period-luminosity relations
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Bhardwaj, A., Ripepi, V., Testa, V., Molinaro, R., Marconi, M., De Somma, G., Trentin, E., Musella, I., Storm, J., Sicignano, T., and Catanzaro, G.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present homogeneous multiband (grizJHKs) time-series observations of 78 Cepheids including 49 fundamental mode variables and 29 first-overtone mode variables. These observations were collected simultaneously using the ROS2 and REMIR instruments at the Rapid Eye Mount telescope. The Cepheid sample covers a large range of distances (0.5 - 19.7 kpc) with varying precision of parallaxes, and thus astrometry-based luminosity fits were used to derive PL and PW relations in optical Sloan (griz) and near-infrared (JHKs) filters. These empirically calibrated relations exhibit large scatter primarily due to larger uncertainties in parallaxes of distant Cepheids, but their slopes agree well with those previously determined in the literature. Using homogeneous high-resolution spectroscopic metallicities of 61 Cepheids covering -1.1 < [Fe/H] < 0.6 dex, we quantified the metallicity dependence of PL and PW relations which varies between $-0.30\pm0.11$ (in Ks) and $-0.55\pm0.12$ (in z) mag/dex in grizJHKs bands. However, the metallicity dependence in the residuals of the PL and PW relations is predominantly seen for metal-poor stars ([Fe/H] < -0.3 dex), which also have larger parallax uncertainties. The modest sample size precludes us from separating the contribution to the residuals due to parallax uncertainties, metallicity effects, and reddening errors. While this Cepheid sample is not optimal for calibrating the Leavitt law, upcoming photometric and spectroscopic datasets of the C-MetaLL survey will allow the accurate derivation of PL and PW relations in the Sloan and near-infrared bandpasses, which will be useful for the distance measurements in the era of the Vera C. Rubin Observatory's Legacy Survey of Space and Time and upcoming extremely large telescopes., Comment: 17 pages, 11 figures, accepted in Astronomy & Astrophysics (abridged abstract)
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- 2024
25. Population structure and vital rates of Shortnose Gar Lepisosteus platostomus in a large floodplain river
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Molinaro, Sarah A., King, Sarah M., Solomon, Levi E., Maxson, Kristopher A., and Stein, Jeffrey A.
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- 2024
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26. Combined alcohol and energy drinks: consumption patterns and risk behaviours among European students
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Scalese, Marco, Cerrai, Sonia, Benedetti, Elisa, Colasante, Emanuela, Cotichini, Rodolfo, and Molinaro, Sabrina
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- 2024
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27. Adaptive Machine Learning Approach for Importance Evaluation of Multimodal Breast Cancer Radiomic Features
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Del Corso, Giulio, Germanese, Danila, Caudai, Claudia, Anastasi, Giada, Belli, Paolo, Formica, Alessia, Nicolucci, Alberto, Palma, Simone, Pascali, Maria Antonietta, Pieroni, Stefania, Trombadori, Charlotte, Colantonio, Sara, Franchini, Michela, and Molinaro, Sabrina
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- 2024
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28. P.A.V.I.A. Study: Pervasiveness and Associated Factors of Video Slot Machine Use in a Large Sample of Italian Adolescents
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Mosconi, Giansanto, Bertuccio, Paola, Albertin, Ilaria, Esposito, Marcello, Polgatti, Anna, Taverna, Franco, Turcinovich, Diego, Russo, Sara, Gaggi, Silvia, Barello, Serena, Amerio, Andrea, Molinaro, Sabrina, Gallus, Silvano, Cecconami, Lorella, Feder, Simone, Vecchi, Tomaso, and Odone, Anna
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- 2024
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29. Molecular Insights into O‑Linked Sialoglycans Recognition by the Siglec-Like SLBR‑N (SLBRUB10712) of Streptococcus gordonii
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Di Carluccio, Cristina, Cerofolini, Linda, Moreira, Miguel, Rosu, Frédéric, Padilla-Cortés, Luis, Gheorghita, Giulia Roxana, Xu, Zhuojia, Santra, Abhishek, Yu, Hai, Yokoyama, Shinji, Gray, Taylor E, St. Laurent, Chris D, Manabe, Yoshiyuki, Chen, Xi, Fukase, Koichi, Macauley, Matthew S, Molinaro, Antonio, Li, Tiehai, Bensing, Barbara A, Marchetti, Roberta, Gabelica, Valérie, Fragai, Marco, and Silipo, Alba
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Chemical Sciences ,Clinical Research ,Infectious Diseases ,Dental/Oral and Craniofacial Disease ,Chemical sciences - Abstract
Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but can also cause local or systemic diseases. Serine-rich repeat (SRR) glycoproteins exposed on the S. gordonii bacterial surface bind to sialylated glycans on human salivary, plasma, and platelet glycoproteins, which may contribute to oral colonization as well as endocardial infections. Despite a conserved overall domain organization of SRR adhesins, the Siglec-like binding regions (SLBRs) are highly variable, affecting the recognition of a wide range of sialoglycans. SLBR-N from the SRR glycoprotein of S. gordonii UB10712 possesses the remarkable ability to recognize complex core 2 O-glycans. We here employed a multidisciplinary approach, including flow cytometry, native mass spectrometry, isothermal titration calorimetry, NMR spectroscopy from both protein and ligand perspectives, and computational methods, to investigate the ligand specificity and binding preferences of SLBR-N when interacting with mono- and disialylated core 2 O-glycans. We determined the means by which SLBR-N preferentially binds branched α2,3-disialylated core 2 O-glycans: a selected conformation of the 3'SLn branch is accommodated into the main binding site, driving the sTa branch to further interact with the protein. At the same time, SLBR-N assumes an open conformation of the CD loop of the glycan-binding pocket, allowing one to accommodate the entire complex core 2 O-glycan. These findings establish the basis for the generation of novel tools for the detection of specific complex O-glycan structures and pave the way for the design and development of potential therapeutics against streptococcal infections.
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- 2024
30. Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement (low-grade appearance): a report of the RANO resect group.
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Karschnia, Philipp, Dietrich, Jorg, Bruno, Francesco, Dono, Antonio, Juenger, Stephanie, Teske, Nico, Young, Jacob, Sciortino, Tommaso, Häni, Levin, van den Bent, Martin, Weller, Michael, Vogelbaum, Michael, Morshed, Ramin, Haddad, Alexander, Molinaro, Annette, Tandon, Nitin, Beck, Juergen, Schnell, Oliver, Bello, Lorenzo, Hervey-Jumper, Shawn, Thon, Niklas, Grau, Stefan, Esquenazi, Yoshua, Rudà, Roberta, Chang, Susan, Berger, Mitchel, Cahill, Daniel, and Tonn, Joerg-Christian
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WHO 2021 ,contrast enhancement ,extent of resection ,glioblastoma ,surgery ,Humans ,Glioblastoma ,Retrospective Studies ,Brain Neoplasms ,Prognosis ,Magnetic Resonance Imaging - Abstract
BACKGROUND: Resection of the contrast-enhancing (CE) tumor represents the standard of care in newly diagnosed glioblastoma. However, some tumors ultimately diagnosed as glioblastoma lack contrast enhancement and have a low-grade appearance on imaging (non-CE glioblastoma). We aimed to (a) volumetrically define the value of non-CE tumor resection in the absence of contrast enhancement, and to (b) delineate outcome differences between glioblastoma patients with and without contrast enhancement. METHODS: The RANO resect group retrospectively compiled a global, eight-center cohort of patients with newly diagnosed glioblastoma per WHO 2021 classification. The associations between postoperative tumor volumes and outcome were analyzed. Propensity score-matched analyses were constructed to compare glioblastomas with and without contrast enhancement. RESULTS: Among 1323 newly diagnosed IDH-wildtype glioblastomas, we identified 98 patients (7.4%) without contrast enhancement. In such patients, smaller postoperative tumor volumes were associated with more favorable outcome. There was an exponential increase in risk for death with larger residual non-CE tumor. Accordingly, extensive resection was associated with improved survival compared to lesion biopsy. These findings were retained on a multivariable analysis adjusting for demographic and clinical markers. Compared to CE glioblastoma, patients with non-CE glioblastoma had a more favorable clinical profile and superior outcome as confirmed in propensity score analyses by matching the patients with non-CE glioblastoma to patients with CE glioblastoma using a large set of clinical variables. CONCLUSIONS: The absence of contrast enhancement characterizes a less aggressive clinical phenotype of IDH-wildtype glioblastomas. Maximal resection of non-CE tumors has prognostic implications and translates into favorable outcome.
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- 2024
31. What Should I Do Now? Goal-Centric Outlooks on Learning, Exploration, and Communication
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Colas, Cédric, Chu, Junyi, Molinaro, Gaia, and Hawkins, Robert
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Artificial Intelligence ,Cognitive Neuroscience ,Linguistics ,Psychology ,Action ,Behavioral Science ,Cognitive development ,Decision making ,Intelligent agents ,Language understanding ,Learning ,Natu - Abstract
Goals are a central pillar of everyday mental activity. From finding your way home to solving a puzzle and ordering food delivery, much of human action and cognition is goal-directed. Perhaps unsurprisingly, theories of goals are a central focus in the psychology of motivation (Elliott & Dweck, 1988), in social and personality psychology (Fishbach & Ferguson, 2007), as well as research aimed at understanding factors contributing to task achievement in educational and industrial settings (Ames & Ames, 1984; Locke & Latham, 2002). In this symposium, we highlight recent work emphasizing a goal-centric outlook on learning, exploration, and communication.
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- 2024
32. Systemic advantage has a meaningful relationship with grade outcomes in students early STEM courses at six research universities.
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Castle, Sarah, Byrd, W, Koester, Benjamin, Pearson, Meaghan, Bonem, Emily, Caporale, Natalia, Cwik, Sonja, Fiorini, Stefano, Li, Yangqiuting, Mead, Chris, Rypkema, Heather, Sweeder, Ryan, Valdivia Medinaceli, Montserrat, Whitcomb, Kyle, Brownell, Sara, Levesque-Bristol, Chantal, Molinaro, Marco, Singh, Chandralekha, McKay, Timothy, Matz, Rebecca, and Denaro, Kameryn
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Course grades ,Generation status ,Grade anomaly ,Income ,Introductory courses ,Race/ethnicity ,STEM ,Sex ,Systemic advantage index ,Undergraduate - Abstract
BACKGROUND: Large introductory lecture courses are frequently post-secondary students first formal interaction with science, technology, engineering, and mathematics (STEM) disciplines. Grade outcomes in these courses are often disparate across student populations, which, in turn, has implications for student retention. This study positions such disparities as a manifestation of systemic inequities along the dimensions of sex, race/ethnicity, income, and first-generation status and investigates the extent to which they are similar across peer institutions. RESULTS: We examined grade outcomes in a selected set of early STEM courses across six large, public, research-intensive universities in the United States over ten years. In this sample of more than 200,000 STEM course enrollments, we find that course grade benefits increase significantly with the number of systemic advantages students possess at all six institutions. The observed trends in academic outcomes versus advantage are strikingly similar across universities despite the fact that we did not control for differences in grading practices, contexts, and instructor and student populations. The findings are concerning given that these courses are often students first post-secondary STEM experiences. CONCLUSIONS: STEM course grades are typically lower than those in other disciplines; students taking them often pay grade penalties. The systemic advantages some student groups experience are correlated with significant reductions in these grade penalties at all six institutions. The consistency of these findings across institutions and courses supports the claim that inequities in STEM education are a systemic problem, driven by factors that go beyond specific courses or individual institutions. Our work provides a basis for the exploration of contexts where inequities are exacerbated or reduced and can be used to advocate for structural change within STEM education. To cultivate more equitable learning environments, we must reckon with how pervasive structural barriers in STEM courses negatively shape the experiences of marginalized students. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40594-024-00474-7.
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- 2024
33. Matched Analysis of Detailed Peripheral Blood and Tumor Immune Microenvironment Profiles in Bladder Cancer
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Chen, Ji-Qing, Salas, Lucas A, Wiencke, John K, Koestler, Devin C, Molinaro, Annette M, Andrew, Angeline S, Seigne, John D, Karagas, Margaret R, Kelsey, Karl T, and Christensen, Brock C
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Biological Sciences ,Genetics ,Urologic Diseases ,Clinical Research ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Inflammatory and immune system ,Humans ,Tumor Microenvironment ,Urinary Bladder Neoplasms ,Cluster Analysis ,DNA Methylation ,Protein Processing ,Post-Translational ,Prognosis ,bladder cancer ,circulating immune profiles ,DNA methylation ,immune profiles ,methylation cytometry ,tumor microenvironment ,Clinical Sciences - Abstract
Background: Bladder cancer and therapy responses hinge on immune profiles in the tumor microenvironment (TME) and blood, yet studies linking tumor-infiltrating immune cells to peripheral immune profiles are limited. Methods: DNA methylation cytometry quantified TME and matched peripheral blood immune cell proportions. With tumor immune profile data as the input, subjects were grouped by immune infiltration status and consensus clustering. Results: Immune hot and cold groups had different immune compositions in the TME but not in circulating blood. Two clusters of patients identified with consensus clustering had different immune compositions not only in the TME but also in blood. Conclusion: Detailed immune profiling via methylation cytometry reveals the significance of understanding tumor and systemic immune relationships in cancer patients.
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- 2024
34. The GAPS programme at TNG LII. Spot modeling of V1298 Tau using SpotCCF tool
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Di Maio, C., Petralia, A., Micela, G., Lanza, A. F., Rainer, M., Malavolta, L., Benatti, S., Affer, L., Maldonado, J., Colombo, S., Damasso, M., Maggio, A., Biazzo, K., Bignamini, A., Borsa, F., Boschin, W., Cabona, L., Cecconi, M., Claudi, R., Covino, E., Di Fabrizio, L., Gratton, R., Lorenzi, V., Mancini, L., Messina, S., Molinari, E., Molinaro, M., Nardiello, D., Poretti, E., and Sozzetti, A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The intrinsic variability due to the magnetic activity of young active stars is one of the main challenges in detecting and characterising exoplanets. We present a method able to model the stellar photosphere and its surface inhomogeneities (starspots) in young/active and fast-rotating stars, based on the cross-correlation function (CCF) technique, to extract information about the spot configuration of the star. Within the Global Architecture of Planetary Systems (GAPS) Project at the Telescopio Nazionale Galileo, we analysed more than 300 spectra of the young planet-hosting star V1298 Tau provided by HARPS-N high-resolution spectrograph. By applying the SpotCCF model to the CCFs we extracted the spot configuration (latitude, longitude and projected filling factor) of this star, and also provided the new RVs time series of this target. We find that the features identified in the CCF profiles of V1298 Tau are modulated by the stellar rotation, supporting our assumption that they are caused by starspots. The analysis suggests a differential rotation velocity of the star with lower rotation at higher latitudes. Also, we find that SpotCCF provides an improvement in RVs extraction with a significantly lower dispersion with respect to the commonly used pipelines, with consequent mitigation of the stellar activity contribution modulated with stellar rotation. A detection sensitivity test, by the direct injection of a planetary signal into the data, confirmed that the SpotCCF model improves the sensitivity and ability to recover planetary signals. Our method enables the modelling of the stellar photosphere, extracting the spot configuration of young/active and rapidly rotating stars. It also allows for the extraction of optimised RV time series, thereby enhancing our detection capabilities for new exoplanets and advancing our understanding of stellar activity., Comment: 18 pages, 20 figures, accepted by A&A
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- 2023
35. First spectroscopic investigation of Anomalous Cepheid variables
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Ripepi, V., Catanzaro, G., Trentin, E., Straniero, O., Mucciarelli, A., Marconi, M., Bhardwaj, A., Fiorentino, G., Monelli, M., Storm, J., De Somma, G., Leccia, S., Molinaro, R., Musella, I., and Sicignano, T.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Anomalous Cepheids (ACEPs) are intermediate mass metal-poor pulsators mostly discovered in dwarf galaxies of the Local Group. However, recent Galactic surveys, including the Gaia DR3, found a few hundreds of ACEPs in the Milky Way. Their origin is not well understood. We aim to investigate the origin and evolution of Galactic ACEPs by studying for the first time the chemical composition of their atmospheres. We used UVES@VLT to obtain high-resolution spectra for a sample of 9 ACEPs belonging to the Galactic halo. We derived the abundances of 12 elements, including C, Na, Mg, Si, Ca, Sc, Ti, Cr, Fe, Ni, Y, and Ba. We complemented these data with literature abundances for an additional three ACEPs that were previously incorrectly classified as type II Cepheids, thus increasing the sample to a total of 12 stars. All the investigated ACEPs have an iron abundance [Fe/H]$<-1.5$ dex as expected from theoretical predictions for these pulsators. The abundance ratios of the different elements to iron show that the ACEP's chemical composition is generally consistent with that of the Galactic halo field stars, except the Sodium, which is found overabundant in 9 out of the 11 ACEPs where it was measured, in close similarity with second-generation stars in the Galactic Globular Clusters. The same comparison with dwarf and ultra-faint satellites of the Milky Way reveals more differences than similarities so it is unlikely that the bulk of Galactic ACEPs originated in such a kind of galaxies which subsequently dissolved in the Galactic halo. The principal finding of this work is the unexpected overabundance of Sodium in ACEPs. We explored several hypotheses to explain this feature, finding that the most promising scenario is the evolution of low-mass stars in a binary system with either mass transfer or merging. Detailed modelling is needed to confirm this hypothesis., Comment: 15 Figures, 4 Tables, Accepted for publication on Astronomy & Astrophysics
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- 2023
36. The GAPS programme at TNG XLIX. TOI-5398, the youngest compact multi-planet system composed of an inner sub-Neptune and an outer warm Saturn
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Mantovan, G., Malavolta, L., Desidera, S., Zingales, T., Borsato, L., Piotto, G., Maggio, A., Locci, D., Polychroni, D., Turrini, D., Baratella, M., Biazzo, K., Nardiello, D., Stassun, K., Nascimbeni, V., Benatti, S., John, A. Anna, Watkins, C., Bieryla, A., Lissauer, J. J., Twicken, J. D., Lanza, A. F., Winn, J. N., Messina, S., Montalto, M., Sozzetti, A., Boffin, H., Cheryasov, D., Strakhov, I., Murgas, F., D'Arpa, M., Barkaoui, K., Benni, P., Bignamini, A., Bonomo, A., Borsa, F., Cabona, L., Cameron, A. C., Claudi, R., Cochran, W., Collins, K. A., Damasso, M., Dong, J., Endl, M., Fukui, A., Furész, G., Gandolfi, D., Ghedina, A., Jenkins, J., Kabáth, P., Latham, D. W., Lorenzi, V., Luque, R., Maldonado, J., McLeod, K., Molinaro, M., Narita, N., Nowak, G., Orell-Miquel, J., Pallé, E., Parviainen, H., Pedani, M., Quinn, S. N., Relles, H., Rowden, P., Scandariato, G., Schwarz, R., Seager, S., Shporer, A., Vanderburg, A., and Wilson, T. G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Short-period giant planets are frequently found to be solitary compared to other classes of exoplanets. Small inner companions to giant planets with $P \lesssim$ 15 days are known only in five compact systems: WASP-47, Kepler-730, WASP-132, TOI-1130, and TOI-2000. Here, we report the confirmation of TOI-5398, the youngest compact multi-planet system composed of a hot sub-Neptune (TOI-5398 c, $P_{\rm c}$ = 4.77271 days) orbiting interior to a short-period Saturn (TOI-5398 b, $P_{\rm b}$ = 10.590547 days) planet, both transiting around a 650 $\pm$ 150 Myr G-type star. As part of the GAPS Young Object project, we confirmed and characterised this compact system, measuring the radius and mass of both planets, thus constraining their bulk composition. Using multidimensional Gaussian processes, we simultaneously modelled stellar activity and planetary signals from TESS Sector 48 light curve and our HARPS-N radial velocity time series. We have confirmed the planetary nature of both planets, TOI-5398 b and TOI-5398 c, alongside a precise estimation of stellar parameters. Through the use of astrometric, photometric, and spectroscopic observations, our findings indicate that TOI-5398 is a young, active G dwarf star (650 $\pm$ 150 Myr), with a rotational period of $P_{\rm rot}$ = 7.34 days. The transit photometry and radial velocity measurements enabled us to measure both the radius and mass of planets b, $R_b = 10.30\pm0.40 R_{\oplus}$, $M_b = 58.7\pm5.7 M_{\oplus}$, and c, $R_c = 3.52 \pm 0.19 R_{\oplus}$, $M_c = 11.8\pm4.8 M_{\oplus}$. TESS observed TOI-5398 during sector 48 and no further observations are planned in the current Extended Mission, making our ground-based light curves crucial for ephemeris improvement. With a Transmission Spectroscopy Metric value of around 300, TOI-5398 b is the most amenable warm giant (10 < $P$ < 100 days) for JWST atmospheric characterisation., Comment: 29 pages, Paper accepted for publication in Astronomy & Astrophysics
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- 2023
37. CAESAR: Space Weather archive prototype for ASPIS
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Molinaro, Marco, Formato, Valerio, Magnafico, Carmelo, Benvenuto, Federico, Perfetti, Alessandro, De Marco, Rossana, Campi, Cristina, Tacchino, Andrea, di Felice, Valeria, Pietropaolo, Ermanno, de Gasperis, Giancarlo, di Fino, Luca, Francisco, Gregoire, Bertello, Igor, Milillo, Anna, Sindoni, Giuseppe, Plainaki, Christina, Giardino, Marco, Polenta, Gianluca, Del Moro, Dario, and Laurenza, Monica
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The project CAESAR (Comprehensive spAce wEather Studies for the ASPIS prototype Realization) is aimed to tackle all the relevant aspects of Space Weather (SWE) and realize the prototype of the scientific data centre for Space Weather of the Italian Space Agency (ASI) called ASPIS (ASI SPace Weather InfraStructure). This contribution is meant to bring attention upon the first steps in the development of the CAESAR prototype for ASPIS and will focus on the activities of the Node 2000 of CAESAR, the set of Work Packages dedicated to the technical design and implementation of the CAESAR ASPIS archive prototype. The product specifications of the intended resources that will form the archive, functional and system requirements gathered as first steps to seed the design of the prototype infrastructure, and evaluation of existing frameworks, tools and standards, will be presented as well as the status of the project in its initial stage., Comment: 4 pages, 2 figures, ADASS XXXII (2022) Proceedings
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- 2023
38. ACES: Generating Diverse Programming Puzzles with with Autotelic Generative Models
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Pourcel, Julien, Colas, Cédric, Molinaro, Gaia, Oudeyer, Pierre-Yves, and Teodorescu, Laetitia
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
The ability to invent novel and interesting problems is a remarkable feature of human intelligence that drives innovation, art, and science. We propose a method that aims to automate this process by harnessing the power of state-of-the-art generative models to produce a diversity of challenging yet solvable problems, here in the context of Python programming puzzles. Inspired by the intrinsically motivated literature, Autotelic CodE Search (ACES) jointly optimizes for the diversity and difficulty of generated problems. We represent problems in a space of LLM-generated semantic descriptors describing the programming skills required to solve them (e.g. string manipulation, dynamic programming, etc.) and measure their difficulty empirically as a linearly decreasing function of the success rate of Llama-3-70B, a state-of-the-art LLM problem solver. ACES iteratively prompts a large language model to generate difficult problems achieving a diversity of target semantic descriptors (goal-directed exploration) using previously generated problems as in-context examples. ACES generates problems that are more diverse and more challenging than problems produced by baseline methods and three times more challenging than problems found in existing Python programming benchmarks on average across 11 state-of-the-art code LLMs.
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- 2023
39. Gaia Focused Product Release: Sources from Service Interface Function image analysis -- Half a million new sources in omega Centauri
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Gaia Collaboration, Weingrill, K., Mints, A., Castañeda, J., Kostrzewa-Rutkowska, Z., Davidson, M., De Angeli, F., Hernández, J., Torra, F., Ramos-Lerate, M., Babusiaux, C., Biermann, M., Crowley, C., Evans, D. W., Lindegren, L., Martín-Fleitas, J. M., Palaversa, L., Mieres, D. Ruz, Tisanić, K., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Barbier, A., Creevey, O. L., Ducourant, C., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Luri, X., Mignard, F., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Soubiran, C., van Leeuwen, F., Audard, M., Bakker, J., Blomme, R., Fabricius, C., Fouesneau, M., Frémat, Y., Galluccio, L., Guerrier, A., Masana, E., Messineo, R., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Roux, W., Seabroke, G. M., Sordo, R., Thévenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cheek, N., Clementini, G., Damerdji, Y., de Teodoro, P., Delchambre, L., DellÓro, A., Garcia, E. Fraile, Garabato, D., García-Lario, P., Torres, N. Garralda, Gavras, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hodgkin, S. T., Holl, B., Jamal, S., Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Álvarez, M. A., Alves, J., Anders, F., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blazere, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Braine, J., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Cantat-Gaudin, T., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Dafonte, C., de Laverny, P., De Luise, F., De March, R., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Durán, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jabłońska, M., Jansen, F., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kóspál, Á, Kun, M., Lambert, S., Lanza, A. F., Campion, J. -F. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Lecoeur-Taibi, I., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marín, Marinoni, S., Marshall, D. J., Lozano, J. Martín, Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Mowlavi, N., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Pegoraro, L., Penttilä, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prša, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Royer, F., Rybicki, K. A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Ségransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tolomei, L., Elipe, G. Torralba, Trabucchi, M., Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, Ł., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Núñez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Gaia's readout window strategy is challenged by very dense fields in the sky. Therefore, in addition to standard Gaia observations, full Sky Mapper (SM) images were recorded for nine selected regions in the sky. A new software pipeline exploits these Service Interface Function (SIF) images of crowded fields (CFs), making use of the availability of the full two-dimensional (2D) information. This new pipeline produced half a million additional Gaia sources in the region of the omega Centauri ($\omega$ Cen) cluster, which are published with this Focused Product Release. We discuss the dedicated SIF CF data reduction pipeline, validate its data products, and introduce their Gaia archive table. Our aim is to improve the completeness of the {\it Gaia} source inventory in a very dense region in the sky, $\omega$ Cen. An adapted version of {\it Gaia}'s Source Detection and Image Parameter Determination software located sources in the 2D SIF CF images. We validated the results by comparing them to the public {\it Gaia} DR3 catalogue and external Hubble Space Telescope data. With this Focused Product Release, 526\,587 new sources have been added to the {\it Gaia} catalogue in $\omega$ Cen. Apart from positions and brightnesses, the additional catalogue contains parallaxes and proper motions, but no meaningful colour information. While SIF CF source parameters generally have a lower precision than nominal {\it Gaia} sources, in the cluster centre they increase the depth of the combined catalogue by three magnitudes and improve the source density by a factor of ten. This first SIF CF data publication already adds great value to the {\it Gaia} catalogue. It demonstrates what to expect for the fourth {\it Gaia} catalogue, which will contain additional sources for all nine SIF CF regions.
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- 2023
- Full Text
- View/download PDF
40. Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars
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Gaia Collaboration, Krone-Martins, A., Ducourant, C., Galluccio, L., Delchambre, L., Oreshina-Slezak, I., Teixeira, R., Braine, J., Campion, J. -F. Le, Mignard, F., Roux, W., Blazere, A., Pegoraro, L., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Babusiaux, C., Barbier, A., Biermann, M., Creevey, O. L., Evans, D. W., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Soubiran, C., van Leeuwen, F., Audard, M., Bakker, J., Blomme, R., Castaneda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Fremat, Y., Guerrier, A., Masana, E., Messineo, R., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Seabroke, G. M., Sordo, R., Thevenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Canovas, H., Carry, B., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., Garcia-Lario, P., Torres, N. Garralda, Gavras, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernandez, J., Hodgkin, S. T., Holl, B., Jamal, S., Jordan, S., Lanzafame, A. C., Loffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nunez, Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Abraham, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Alvarez, M. A., Alves, J., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolome, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Crowley, C., Dafonte, C., de Laverny, P., De Luise, F., De March, R., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Duran, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatovic, M., Fedorets, G., Fernandez-Hernandez, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., Garcia-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., Gonzalez-Nunez, J., Gonzalez-Santamaria, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutierrez-Sanchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jablonska, M., Jansen, F., Jimenez-Arranz, O., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kospal, A., Kostrzewa-Rutkowska, Z., Kun, M., Lambert, S., Lanza, A. F., Lebreton, Y., Lebzelter, T., Leccia, S., Lecoeur-Taibi, I., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrom, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marin, Marinoni, S., Marshall, D. J., Lozano, J. Martin, Martin-Fleitas, J. M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Mints, A., Molina, D., Molinaro, R., Molnar, L., Monari, G., Monguio, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Mowlavi, N., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Penttila, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prsa, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reyle, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gomez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Nunez, A. Saez, Selles, A. Sagrista, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santovena, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Segransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmuller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Tisanic, K., Tolomei, L., Torra, F., Elipe, G. Torralba, Trabucchi, M., Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, L., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Nunez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of $0.18$" in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as those expected for most lenses. Aims. We present the Data Processing and Analysis Consortium GravLens pipeline, which was built to analyse all Gaia detections around quasars and to cluster them into sources, thus producing a catalogue of secondary sources around each quasar. We analysed the resulting catalogue to produce scores that indicate source configurations that are compatible with strongly lensed quasars. Methods. GravLens uses the DBSCAN unsupervised clustering algorithm to detect sources around quasars. The resulting catalogue of multiplets is then analysed with several methods to identify potential gravitational lenses. We developed and applied an outlier scoring method, a comparison between the average BP and RP spectra of the components, and we also used an extremely randomised tree algorithm. These methods produce scores to identify the most probable configurations and to establish a list of lens candidates. Results. We analysed the environment of 3 760 032 quasars. A total of 4 760 920 sources, including the quasars, were found within 6" of the quasar positions. This list is given in the Gaia archive. In 87\% of cases, the quasar remains a single source, and in 501 385 cases neighbouring sources were detected. We propose a list of 381 lensed candidates, of which we identified 49 as the most promising. Beyond these candidates, the associate tables in this Focused Product Release allow the entire community to explore the unique Gaia data for strong lensing studies further., Comment: 35 pages, 60 figures, accepted for publication by Astronomy and Astrophysics
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- 2023
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41. Gaia Focused Product Release: Radial velocity time series of long-period variables
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Gaia Collaboration, Trabucchi, M., Mowlavi, N., Lebzelter, T., Lecoeur-Taibi, I., Audard, M., Eyer, L., García-Lario, P., Gavras, P., Holl, B., de Fombelle, G. Jevardat, Nienartowicz, K., Rimoldini, L., Sartoretti, P., Blomme, R., Frémat, Y., Marchal, O., Damerdji, Y., Brown, A. G. A., Guerrier, A., Panuzzo, P., Katz, D., Seabroke, G. M., Benson, K., Haigron, R., Smith, M., Lobel, A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Babusiaux, C., Barbier, A., Biermann, M., Creevey, O. L., Ducourant, C., Evans, D. W., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Randich, S., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Lattanzi, M. G., Soubiran, C., van Leeuwen, F., Bakker, J., Castañeda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Galluccio, L., Masana, E., Messineo, R., Nicolas, C., Pailler, F., Riclet, F., Roux, W., Sordo, R., Thévenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cheek, N., Clementini, G., Davidson, M., de Teodoro, P., Delchambre, L., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., Torres, N. Garralda, Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernández, J., Hodgkin, S. T., Jamal, S., Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Álvarez, M. A., Alves, J., Anders, F., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blazere, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Braine, J., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Crowley, C., Dafonte, C., David, M., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Durán, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jabłońska, M., Jansen, F., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kóspál, Á, Kostrzewa-Rutkowska, Z., Kun, M., Lambert, S., Lanza, A. F., Campion, J. -F. Le, Lebreton, Y., Leccia, S., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marín, Marinoni, S., Marshall, D. J., Lozano, J. Martín, Martín-Fleitas, J. M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Mints, A., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Pegoraro, L., Penttilä, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prša, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Ségransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tisanić, K., Tolomei, L., Torra, F., Elipe, G. Torralba, Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, Ł., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Núñez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The third Gaia Data Release (DR3) provided photometric time series of more than 2 million long-period variable (LPV) candidates. Anticipating the publication of full radial-velocity (RV) in DR4, this Focused Product Release (FPR) provides RV time series for a selection of LPVs with high-quality observations. We describe the production and content of the Gaia catalog of LPV RV time series, and the methods used to compute variability parameters published in the Gaia FPR. Starting from the DR3 LPVs catalog, we applied filters to construct a sample of sources with high-quality RV measurements. We modeled their RV and photometric time series to derive their periods and amplitudes, and further refined the sample by requiring compatibility between the RV period and at least one of the $G$, $G_{\rm BP}$, or $G_{\rm RP}$ photometric periods. The catalog includes RV time series and variability parameters for 9\,614 sources in the magnitude range $6\lesssim G/{\rm mag}\lesssim 14$, including a flagged top-quality subsample of 6\,093 stars whose RV periods are fully compatible with the values derived from the $G$, $G_{\rm BP}$, and $G_{\rm RP}$ photometric time series. The RV time series contain a mean of 24 measurements per source taken unevenly over a duration of about three years. We identify the great most sources (88%) as genuine LPVs, with about half of them showing a pulsation period and the other half displaying a long secondary period. The remaining 12% consists of candidate ellipsoidal binaries. Quality checks against RVs available in the literature show excellent agreement. We provide illustrative examples and cautionary remarks. The publication of RV time series for almost 10\,000 LPVs constitutes, by far, the largest such database available to date in the literature. The availability of simultaneous photometric measurements gives a unique added value to the Gaia catalog (abridged), Comment: 36 pages, 38 figures
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- 2023
42. Cepheid Metallicity in the Leavitt Law (C- MetaLL) survey: IV. The metallicity dependence of Cepheid Period-Luminosity relations
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Trentin, E., Ripepi, V., Molinaro, R., Catanzaro, G., Storm, J., De Somma, G., Marconi, M., Bhardwaj, A., Gatto, M., Testa, V., Musella, I., Clementini, G., and Leccia, S.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Classical Cepheids (DCEPs) play a fundamental role in the calibration of the extra-galactic distance ladder which eventually leads to the determination of the Hubble constant($H_0$) thanks to the period-luminosity ($PL$) and period-Wesenheit ($PW$) relations exhibited by these pulsating variables. Therefore, it is of great importance to establish the dependence of $PL/PW$ relations on metallicity. We aim at quantifying the metallicity dependence of the Galactic DCEPs' $PL/PW$ relations for a variety of photometric bands ranging from optical to near-infrared. We gathered a literature sample of 910 DCEPs with available [Fe/H] values from high-resolution spectroscopy or metallicities from \gaia\ Radial Velocity Spectrometer. For all these stars, we collected photometry in the $G_{BP},G_{RP},G,I,V,J,H,K_S$ bands and astrometry from the \gaia\ DR3. These data have been used to investigate the metal dependence of both intercepts and slopes of a variety of $PL/PW$ relations at multiple wavelengths. We find a large negative metallicity effect on the intercept ($\gamma$ coefficient) of all the $PL/PW$ relations investigated in this work, while present data still do not allow us to draw firm conclusions regarding the metal dependence of the slope ($\delta$ coefficient). The typical values of $\gamma$ are around $-0.4:-0.5$ mag/dex, i.e. larger than most of the recent determinations present in the literature. We carried out several tests which confirm the robustness of our results. As in our previous works, we find that the inclusion of global zero point offset of \gaia\ parallaxes provides smaller values of $\gamma$ (in an absolute sense). However, the assumption of the geometric distance of the LMC seems to indicate that larger values of $\gamma$ (in an absolute sense) would be preferred., Comment: 20 pages, 26 figures. Accepted for publication on A&A. This new version contains corrections from the language editor and a revision of the analysis due to a typo found in the literature
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- 2023
43. Systemic Advantage Has a Meaningful Relationship with Grade Outcomes in Students' Early STEM Courses at Six Research Universities
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Sarah D. Castle, W. Carson Byrd, Benjamin P. Koester, Meaghan I. Pearson, Emily Bonem, Natalia Caporale, Sonja Cwik, Kameryn Denaro, Stefano Fiorini, Yangqiuting Li, Chris Mead, Heather Rypkema, Ryan D. Sweeder, Montserrat B. Valdivia Medinaceli, Kyle M. Whitcomb, Sara E. Brownell, Chantal Levesque-Bristol, Marco Molinaro, Chandralekha Singh, Timothy A. McKay, and Rebecca L. Matz
- Abstract
Background: Large introductory lecture courses are frequently post-secondary students' first formal interaction with science, technology, engineering, and mathematics (STEM) disciplines. Grade outcomes in these courses are often disparate across student populations, which, in turn, has implications for student retention. This study positions such disparities as a manifestation of systemic inequities along the dimensions of sex, race/ethnicity, income, and first-generation status and investigates the extent to which they are similar across peer institutions. Results: We examined grade outcomes in a selected set of early STEM courses across six large, public, research-intensive universities in the United States over ten years. In this sample of more than 200,000 STEM course enrollments, we find that course grade benefits increase significantly with the number of systemic advantages students possess at all six institutions. The observed trends in academic outcomes versus advantage are strikingly similar across universities despite the fact that we did not control for differences in grading practices, contexts, and instructor and student populations. The findings are concerning given that these courses are often students' first post-secondary STEM experiences. Conclusions: STEM course grades are typically lower than those in other disciplines; students taking them often pay grade penalties. The systemic advantages some student groups experience are correlated with significant reductions in these grade penalties at all six institutions. The consistency of these findings across institutions and courses supports the claim that inequities in STEM education are a systemic problem, driven by factors that go beyond specific courses or individual institutions. Our work provides a basis for the exploration of contexts where inequities are exacerbated or reduced and can be used to advocate for structural change within STEM education. To cultivate more equitable learning environments, we must reckon with how pervasive structural barriers in STEM courses negatively shape the experiences of marginalized students.
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- 2024
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44. Using Motivation Assessment as a Teaching Tool for Large Undergraduate Courses: Reflections from the Teaching Team
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Melissa Ferland, Claudia F. Molinaro, Jeff J. Kosovich, and Jessica K. Flake
- Abstract
Introduction: Student motivation is a critical predictor of academic achievement, engagement, and success in higher education. Motivating students is a crucial aspect of effective teaching. Statement of the Problem: Although there is a wealth of research on student motivation, practical guidance for putting theory into practice in challenging teaching environments (i.e., large-format introductory courses) is lacking. We discuss a first step toward motivating students: understanding how motivated they are and using that information to inform teaching. Literature Review: Anxiety, impeded motivation, and high student-to-teacher ratio are all challenges associated with teaching foundational introductory courses, such as statistics. The Expectancy-Value-Cost model of motivation provides theoretical background to assist with these courses. We discuss the implementation and use of motivation assessments as a teaching tool. Teaching Implications: Motivation assessments are feasible and useful while teaching large-format introductory courses. Instructor reflections lend insights as to how to use these assessments to improve pedagogy.
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- 2024
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45. Information complexity of mixed-integer convex optimization
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Basu, Amitabh, Jiang, Hongyi, Kerger, Phillip, and Molinaro, Marco
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- 2024
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46. A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron
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Sharma, Garima, Sharma, Amit, Kim, Inhae, Cha, Dong Gon, Kim, Somi, Park, Eun Seo, Noh, Jae Gyun, Lee, Juhee, Ku, Ja Hyeon, Choi, Yoon Ha, Kong, JungHo, Lee, Haena, Ko, Haeun, Lee, Juhun, Notaro, Anna, Hong, Seol Hee, Rhee, Joon Haeng, Kim, Sang Geon, De Castro, Cristina, Molinaro, Antonio, Shin, Kunyoo, Kim, Sanguk, Kim, Jong Kyoung, Rudra, Dipayan, and Im, Sin-Hyeog
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- 2024
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47. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
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Gill, Pavan, Puchalt, Nicolas Garrido, Molinaro, Thomas, Werner, Marie, Seli, Emre, Hotaling, James, and Cheng, Philip
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- 2024
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48. Management of patients with extensive locally advanced thyroid cancer: results of multimodal treatments
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Prete, A., Pieroni, E., Marrama, E., Bruschini, L., Ferrari, M., Scioti, G., Aprile, V., Guarracino, F., Ambrosini, C. E., Molinaro, E., Elisei, R., Lucchi, M., and Materazzi, G.
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- 2024
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49. A theoretical and computational analysis of full strong-branching
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Dey, Santanu S., Dubey, Yatharth, Molinaro, Marco, and Shah, Prachi
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- 2024
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50. Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica
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Andretta, Emanuela, De Chiara, Stefania, Pagliuca, Chiara, Cirella, Roberta, Scaglione, Elena, Di Rosario, Martina, Kokoulin, Maxim S., Nedashkovskaya, Olga I., Silipo, Alba, Salvatore, Paola, Molinaro, Antonio, and Di Lorenzo, Flaviana
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- 2024
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