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Ovarian cancer ranks third among the tumors of the reproductive system in women. This disease has no screening.It is characterized by a latent course and, as a result, is diagnosed at the advanced stages of the tumor process. There are two methods of treatment for this disease: aggressive cytoreductive surgery and anticancer drug therapy. However, the phasing of approaches causes controversy among oncologists. This article will consider approaches to choosing the stage of treatment for patients with advanced ovarian cancer based on the analysis of international studies.

The article deals with forecasting the values of economic growth factors in a region on the example of the Udmurt Republic. A statistically significant multiple linear regression equation (that explains the dynamics of the gross regional product from the signs-factors) is derived, a factorial forecast is developed and the results obtained are interpreted. Deflation method has been applied to eliminate the impact of price growth and GRP value has been calculated in 2007 prices. On the basis of multiple regression analysis, a matrix of paired correlation coefficients is calculated and informative factors of the model are selected. The significance of paired correlation coefficients is checked. The model is constructed in its natural form with informative factors only. The statistical significance of the regression coefficients is evaluated with the help of the Student's t -criterion, the quality of the equation is estimated through the average approximation error, which confirm the sufficiently high quality of the model. The predicted value of the result is calculated. It was found that if the current trends in the dynamics of these factors persist, we can expect the growth of real (physical volume) GRP over the period 2016-2020 by 26 % or 5.5 % annually, which meets the requirements of economic security of the region. The above information can be used to develop programs of regional economic development and design in the system of state and municipal administration.

The opinion article is devoted to the analysis of a large-scale comprehensive systematic review of relevant and practically oriented studies of vortioxetine use in depression for the period to 2020. The mechanisms of multimodal action, issues of efficacy and safety of the drug, including direct procognitive effects, effects on anhedonia, anxiety, sleep disorders, analgesic and anti-inflammatory effects are highlighted. An increase in the efficacy of vortioxetine when the dose is increased to 20 mg/day is emphasized. Prospective directions for antidepressant research are outlined.Публикация посвящена анализу масштабного систематического обзора актуальных и практически ориентированных исследований применения вортиоксетина при депрессии за период до 2020 г. Освещаются механизмы мультимодального действия, вопросы эффективности и безопасности применения препарата, в том числе прямого прокогнитивного эффекта, воздействия на ангедонию, тревогу, нарушения сна, анальгетического и противовоспалительного действия. Подчеркивается возрастание эффективности вортиоксетина при повышении дозы до 20 мг/сут. Намечены перспективные направления исследования антидепрессанта.

A tendency to form multiferroic states with a spatially modulated antiferromagnetic structure and electric polarization in pure orthorhombic manganites RMnO 3 upon decreasing of the rare-earth ionic radii has been realized in single crystals of substituted compounds Eu 1x- Y x MnO 3 (0.2 ≤ x ≤ 0.5) and Gd 1-y Y y MnO 3 (0 < y ≤ 0.2). While the parent pure and slightly substituted (x ≤ 0,1) compounds exhibited a spontaneous transition from the incommensurate (IC) to the canted antiferromagnetic (CAF) state at T CA < T N = 45-50 K, the transitions from IC to commensurate ferroelectric (C/FE) phase were observed at T lock < T N for x ≥ 0.3 and y ≥ 0.05 accompanied by dielectric anomalies. Various phase transitions were observed in magnetic fields up to 250 kOe along the a-, b-, c-axes by magnetization, magnetostriction and electric polarization measurements. The latter indicate the existence of a spontaneous electric polarization below T lock .

Migration of seismic data may be presented as two different steps – continuation of wavefield inside the medium and imaging in each point of medium. Wavefield continuation by finite-difference scheme is applicable for any complexity velocity models and is used in HDS (High Definition Seismic) technology. The paper presents the results of a simple approach to migration of 1C data. In this case continuation of a wavefield of the reflected waves is made in reverse-time with correlation, for example, with the Ricker impulse on the DP-wave arrival time, calculated by the ray method, in all finite-difference knots. The results of such migration for 2D and 3D velocity models show the possibility of constructing realistic images for variable dip boundaries

The acoustic method of measurement of the speed and direction of motion of turbulent air is discussed. The method is based on the Doppler effect and lets us adequately measure the wind speed up to 330 m/s - the acoustic wave velocity in air. For supervising weak air turbulence it is suggested that the phase difference of the signal is measured with respect to a reference one. The analysis of errors of the measuring device is presented in the paper. The complex compensation of the influence of atmospheric conditions on the measurements is suggested. The results of phase propagation in open measuring channels are compared with the results in a channel that is protected from wind influence but has the other properties of an open channel. The phase propagation in the reference channel is assumed as the reference point.

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Submillimeter dynamic properties (dielectric permittivity e′(ν,T), dynamic conductivity σ′(ν,T)) at frequencies ν=3–20 cm−1 as well as static ones (magnetization, AC magnetic susceptibility, resistance and magnetoresistance) of the La1−xSrxMnO3 (x=0.1, 0.175, 0.2 and 0.3) ferromagnets have been studied at temperatures between 5 K and 400 K. A sharp increase of σ′(ν,T) was observed near the Curie temperature at a metal–semiconductor transition in La0.825Sr0.175MnO3. σ′(ν,T) was described by the Drude model and was equal or slightly greater than its static value. In La0.9Sr0.1MnO3 σ′(ν,T) was considerably greater than the static value, because not only the Drude-like charge carriers contribute to the dynamic conductivity σ′(ν,T) but also the crystal lattice. A significant anisotropy of e′(T) was observed for different crystallographic directions. A jump of e′(T) as well as anomalies in the AC magnetic susceptibility were found at T=100–120 K in La0.9Sr0.1MnO3 which indicate the existence of an additional phase transition (polaron ordering) besides the magnetic transition at 160 K.

Magnetic gyrotropy effects near antiferromagnetic resonance (AFMR) determined by weak ferromagnetism (YFeO 3 ) and magnetoelectric effect (Cr 2 O 3 ) have been studied using quasi-optical submillimeter backward-wave-oscillator technique in the frequency range 3.2–13 cm −1 . A noticeable rotation of an optical indicatrix and increase of an ellipticity have been revealed near AFMR in both antiferromagnets, which present a manifestation of a Faraday rotation in YFeO 3 and gyrotropic birefringence in Cr 2 O 3 . Theoretical calculations and computer simulations made it possible to describe the observed spectra, taking into account the resonance behaviour of magnetic, magnetoelectric and electric susceptibilities, and to determine corresponding parameters, in particular, an AFMR mode contribution to the static magnetic and magnetoelectric susceptibilities.

Antiferromagnetic resonance (AFMR) have been studied in La1−xSrxMnO3 single crystals (0 25 cm −1 at T=3– 300 K . Two AFMR modes, quasiferromagnetic (F) and quasiantiferromagnetic (AF) were observed and studied below TN. A strong decrease of the resonance frequency of the F-mode was revealed with increasing x, while the frequency of the AF-mode is only slightly decreased (20%). The observed behaviour of the AFMR modes corresponds to a canted magnetic structure and its evolution with increasing x.

We report on detailed susceptibility, magnetization and magnetoresistance studies in La1−xSrxMnO3 for x⩽0.2. We arrive at a phase diagram which shows a ferromagnetic and insulating ground state for 0.1⩽x⩽0.15, followed by a canted antiferromagnetic phase at higher temperatures. The ferromagnetic transition is strongly coupled to a structural transition from a Jahn–Teller distorted phase to a pseudocubic orthorhombic phase, and is accompanied by the appearance of large positive magnetoresistance effects. We interpret the rich phase diagram close to x= 1 8 in terms of orbital ordering, due to an interplay of superexchange interactions and Jahn–Teller distortions. In addition, we report on the temperature dependence of phonon spectra and on optical conductivities. The temperature dependence of bending and stretching modes clearly indicate the structural and magnetic-phase transitions. The optical conductivities are explained in terms of small polaron absorption.

Dynamic properties and magnetic excitations in PrBa 2 Cu 3 O 6 were investigated by means of a quasi-optical submillimeter backward-wave-oscillator technique and a Fourier spectrometer at the wavelengths v = 4 – 33 and 50–650 cm −1 , respectively. A weak and wide absorption line was observed in the submillimeter transmission spectra near 15 cm −1 at T , which was identified as a rare-earth mode originating from electronic transitions between the low-energy crystal-field states of Pr 3+ . Temperature dependence of the resonance frequency, linewidth and mode contribution to static magnetic permeability were obtained. Dynamic magnetic susceptibility χ(ω, q, T) and resonance frequencies ω(q, T) of the magnetic excitations of the Pr-subsystem were calculated and analyzed above and below the Neel temperature (T N = 10K).

We have revealed a strong influence of non-magnetic impurity Al 3+ ions (magnetic vacancies) on spin excitations in GdFe 0.9 Al 0.1 O 3 and HoFe 0.925 Al 0.075 O 3 at frequencies ν = 2–33 cm −1 . A significant growth of the frequencies of both AFMR modes ν 1 and ν 2 at low temperatures was found in GdFe 0.9 Al 0.1 O 3 as against the pure GdFeO 3 . The anomalies observed in the behaviour of AFMR modes for HoFe 0.925 Al 0.075 O 3 at T M = 60 K make evidence for a new first-order spin reorientational phase transition from Γ 4 ( G x F z ) phase to antiferromagnetic phase Γ 1 (G y ) induced by the magnetic vacancies.

Dielectric and magnetic properties of Gd2CuO4 single crystal were investigated by means of FIR reflectivity and submillimeter transmissivity measurements at temperatures 5 – 300 K. Besides the four known Eu optical phonon modes we observed unexpected phonon lines at 104, 136 and 577 cm−1, which could be caused by structural deformations in the T' phase. The observed behaviour of Cu AFMR mode confirms the existence of the weak ferromagnetic moment and testifies to the strong influence of the Cu-Gd exchange on the magnetic properties of Gd2CuO4.