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Purpose: To compare the training characteristics of an elite team pursuit cycling squad in the 3-month preparation phases prior to 2 successive world-record (WR) performances. Methods: Training data of 5 male track endurance cyclists (mean [SD]; age 23.4 [3.46] y; body mass 80.2 [2.74] kg; 4.5 [0.17] W·kg−1 at LT2; maximal aerobic power 6.2 [0.27] W·kg−1; maximal oxygen uptake 65.9 [2.89] mL·kg−1·min−1) were analyzed with weekly total training volume by training type and heart rate, power output, and torque intensity distributions calculated with reference to the respective WRs' performance requirements. Results: Athletes completed 805 (82.81) and 725 (68.40) min·wk–1 of training, respectively, in each season. In the second season, there was a 32% increase in total track volume, although track sessions were shorter (ie, greater frequency) in the second season. A pyramidal intensity distribution was consistent across both seasons, with 81% of training, on average, performed below LT1 power output each week, whereas 6% of training was performed above LT2. Athletes accumulated greater volume above WR team pursuit lead power (2.4% vs 0.9%) and torque (6.2% vs 3.2%) in 2019. In one athlete, mean single-leg-press peak rate of force development was 71% and 46% higher at mid- and late-phases, respectively, during the preparation period. Conclusions: These findings provide novel insights into the common and contrasting methods contributing to successive WR team pursuit performances. Greater accumulation of volume above race-specific power and torque (eg, team pursuit lead), as well as improved neuromuscular force-generating capacities, may be worthy of investigation for implementation in training programs. [ABSTRACT FROM AUTHOR]

Purpose: To profile the training characteristics of an elite team pursuit cycling squad and assess variations in training intensity and load accumulation across the 36-week period prior to a world-record performance at the 2018 Commonwealth Games. Methods: Training data of 5 male track endurance cyclists (mean [SD]; age 21.9 [3.52] y; 4.4 [0.16] W·kg−1 at anaerobic threshold; 6.2 [0.28] W·kg−1 maximal oxygen uptake 68.7 [2.99] mL kg·min−1) were analyzed with weekly total training volume and heart rate, power output, and torque intensity distributions calculated with reference to their 3:49.804 min:s.ms performance requirements for a 4-km team pursuit. Results: Athletes completed 543 (37) h−1 of training across 436 (16) sessions. On-bike activities accounted for 69.9% of all training sessions, with participants cycling 11,246 (1139) km−1 in the training period of interest, whereas 12.7% of sessions involved gym/strength training. A pyramidal intensity distribution was evident with over 65% and 70% of training, respectively, performed at low-intensity zone heart rate and power output, whereas 5.3% and 7.7% of training was performed above anaerobic threshold. The athletes accumulated 4.4% of total training volume at, or above, their world-record team pursuit lead position torque (55 N·m). Conclusions: These data provide updated and novel insight to the power and torque demands and load accumulation contributing to world-record team pursuit performance. Although the observed pyramidal intensity distribution is common in endurance sports, the lack of shift toward a polarized intensity distribution during taper and competition peaking differs from previous research. [ABSTRACT FROM AUTHOR]

Background: Spiroergometry is important for modern performance diagnostics, and reference values have been evaluated for bicycle and treadmill ergometers. The aim of this study is to assess the comparability of bicycle and hand-crank spiroergometry and its associated parameters, as hand-crank spiroergometry can be used during rehabilitation in patients with definitive or temporally impairment of the lower extremity. Methods: Thirty-seven healthy volunteers completed 2 exhausting performance diagnostics on hand-crank and bicycle spiroergometry. Participants' anthropometric characteristics, maximum power, multiple exertion criteria, maximum aerobic capacity, and maximum heart rate were detected, and ventilatory and metabolic thresholds were determined. Results: The maximum power, maximum heart rate, maximum aerobic capacity, and ventilatory thresholds were significant higher on the bicycle ergometer (P <.001). The metabolic thresholds occurred on higher lactate values on the hand-crank ergometer. Equations for calculating maximum aerobic capacity from the maximum power measured in either hand-crank or bicycle ergometer could be found through regression analysis. Conclusions: Although there are problems in interpreting results of different ergometries due to severe physiology differences, the equations can be used for patients who are temporally unable to complete the established ergometry due to a deficit in the lower extremity. This could improve training recommendations for patients and para-athletes in particular. [ABSTRACT FROM AUTHOR]

Objective: Passive stiffness, a biomechanical parameter, has a potential influence on running economy, thus playing a pivotal role in performance. This study aimed to quantify passive stiffness of the Achilles tendon and gastrocnemius muscle using myotonometry throughout an incremental running protocol. Methods: Twenty-one male participants underwent a multistage incremental test (Bordeaux test) on a treadmill until exhaustion. Passive stiffness of the gastrocnemius muscle and Achilles tendon was measured using a MyotonPRO device. Measurements were taken before, during, and after the incremental test. Results: Our findings indicated that passive stiffness of the medial gastrocnemius decreased at rest between prerun and postrun assessments (−20.12 N·m−1, P =.012). Furthermore, during the test, stiffness increased at low intensity (at 50% of maximal aerobic speed: +104.8 N·m−1, P =.042), returning to baseline values as intensity increased. Conclusions: Throughout an incremental running protocol, both Achilles tendon and gastrocnemius muscle stiffness initially increased and then decreased with escalating percentages of maximal aerobic speed. A deeper understanding of stiffness in running can inform more effective recommendations for runners' strengthening and training. [ABSTRACT FROM AUTHOR]

The decision of the Union Internationale de Pentathlon Moderne to replace horse riding with Obstacle after the 2024 Olympic Games challenges training, testing, and recovery management in Modern Pentathlon. This commentary discusses physiological, technical, and tactical effects of rule changes in the 5 disciplines with a specific focus on the new discipline Obstacle. Modern Pentathlon requires athletes to develop specific endurance capacities relying on both the aerobic and anaerobic systems while simultaneously increasing lower- and upper-body strength capabilities. In addition, movements must be repeatedly executed in an explosive and precise manner. Running and swimming must be fast but economical. Swapping from horse riding to Obstacle will prioritize the explosive strength of the upper extremities and core while keeping high levels of endurance and precision in swimming, fencing, and shooting. Moreover, condensing the Modern Pentathlon competition to a 90-minute television-friendly format enables more competitions in the future. Athletes and coaches will thus also need to develop and maintain effective individual peri-exercise routines (before, during, and after the competition) to successfully meet the resulting tactical and physical challenges of the new format. This commentary aims to stimulate the discussion on the effect of the Union Internationale de Pentathlon Moderne's decisions to replace riding with the new Obstacle discipline and implement a more television-friendly format with a focus on physiological, technical, and tactical aspects. [ABSTRACT FROM AUTHOR]

Purpose: Long-distance running performance has been reported to be associated with sprint performance in highly trained distance runners. Therefore, we hypothesized that sprint training could enhance distance running and sprint performance in long-distance runners. This study examined the effect of 6-week sprint training on long-distance running and sprint performance in highly trained distance runners. Methods: Nineteen college runners were divided into control (n = 8) and training (n = 11) groups. Participants in the training group performed 12 sprint training sessions in 6 weeks, while those in the control group performed 12 distance training sessions. Before and after the interventions, maximal oxygen uptake ( V ˙ O 2 max), O2 cost during submaximal running (290 m·min−1 and 310 m·min−1 of running velocity), and time to exhaustion (starting at 290 m·min–1 and increased 10 m·min–1 every minute) were assessed on a treadmill. Additionally, the 100-m and 400-m sprinting times and 3000-m running time were determined on an all-weather track. Results: In the control group, no measurements significantly changed after the intervention. In the training group, the time to exhaustion, 100-m and 400-m sprinting times, and 3000-m running time improved significantly, while V ˙ O 2 max and O2 cost did not change. Conclusions: These results showed that 6-week sprint training improved both sprint and long-distance running performance in highly trained distance runners without a change in aerobic capacity. Improvement in the time to exhaustion without a change in V ˙ O 2 max suggests that the enhancement of long-distance running performance could be attributable to improved anaerobic capacity. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to cross-validate a recently proposed equation for the prediction of maximal oxygen uptake ( V ˙ O 2 max) in cycling exercise by using the average power output normalized by the body mass from a 5-minute time trial (RPO5-min) as the independent variable. Further, the study aimed to update the predictive equation using Bayesian informative prior distributions and meta-analysis. Methods: On different days, 49 male cyclists performed an incremental graded exercise test until exhaustion and a 5-minute time trial on a stationary cycle ergometer. We compared the actual V ˙ O 2 max with the predicted value obtained from the RPO5-min, using a modified Bayesian Bland–Altman agreement analysis. In addition, this study updated the data on the linear regression between V ˙ O 2 max and RPO5-min, by incorporating information from a previous study as a Bayesian informative prior distribution or via meta-analysis. Results: On average, the predicted V ˙ O 2 max using RPO5-min underestimated the actual V ˙ O 2 max by −6.6 mL·kg–1·min–1 (95% credible interval, −8.6 to −4.7 mL·kg–1·min–1). The lower and upper 95% limits of agreement were −17.2 (−22.7 to −12.3) and 3.8 (−1.0 to 9.5) mL·kg–1·min–1, respectively. When the current study's data were analyzed using the previously published data as a Bayesian informative prior distribution, the accuracy of predicting sample means was found to be better when compared with the data combined via meta-analyses. Conclusions: The proposed equation presented systematic bias in our sample, in which the prediction underestimated the actual V ˙ O 2 max. We provide an updated equation using the previous one as the prior distribution, which could be generalized to a greater audience of cyclists. [ABSTRACT FROM AUTHOR]

Purpose: The monitoring of training loads and quantification of physical performance are common practices in youth soccer academies to support coaches in prescribing and programming training for individuals. The interaction between training load and physical performance is unknown during a preseason period in youth soccer players. The current study assessed changes in training load and physical assessments across a 4-week preseason period. The relationship between physical performance and match playing time in youth male soccer players was also investigated. Methods: The training loads of 25 professional youth academy male soccer players were monitored throughout a 4-week preseason period. Assessments of power, agility, speed, and aerobic capacity were undertaken in the first training session. Session ratings of perceived exertion (sRPE) and well-being questionnaires were collected during all training sessions and preseason matches. Playing time during subsequent competitive matches was recorded. Results: T test and 30-m-sprint assessments, conducted on the first day of preseason, were predictors of sRPE throughout preseason (t test χ2/df = 2.895, poor adjustment; 30-m sprint χ2/df = 1.608, good adjustment). YoYo Test performance was related with changes in perceived fatigue (χ2/df = 0.534, very good adjustment). Faster players reported higher values of sRPE, and players with higher aerobic capacity reported higher levels of fatigue across preseason. Well-being, perceived fatigue and soreness, and sRPE decreased across preseason. Greater match durations were related to higher levels of fatigue during preseason (P <.05). Conclusion: The current study highlights the relationship between training load, physical assessments, and playing time. Coaches and practitioners can use physical test data at the start of preseason as an indication of players that report higher sRPE, perceived fatigue, and reduced well-being across preseason, supporting decisions around individualized training prescriptions. [ABSTRACT FROM AUTHOR]

Purpose: We compared the adaptive responses to supramaximal high-intensity interval training (HIIT) individualized according to anaerobic speed reserve (ASR), the 30-15 Intermittent Fitness Test (VIFT), and velocity associated with maximum oxygen uptake (MAS) to determine which approach facilitates more identical adaptations across athletes with different profiles. Methods: Thirty national-level basketball players (age = 28.4 [5] y; body mass = 88.9 [6.3] kg; height = 190 [4.8] cm) were randomly assigned to 3 training groups performing 2 sets of 4, 6, 8, 6, 8, and 10-minute runs (from first to sixth week, respectively), consisting of 15-second running at Δ%20ASR (MAS + 0.2 × ASR), 95%VIFT, and 120%MAS, with 15 seconds recovery between efforts and a 3-minute relief between sets. Results: All 3 interval interventions significantly (P <.05) enhanced maximum oxygen uptake ( V ˙ O 2 max), oxygen pulse ( V ˙ O 2 / HR), first and second ventilatory threshold (VT1 and VT2), cardiac output ( Q ˙ max ), stroke volume, peak and average power output, testosterone levels, and testosterone-to-cortisol ratio following the training period. Different values of interindividual variability (coefficient of variation) for the percentage changes of the measured variables were observed in response to HIITASR, HIITvIFT, and HIITMAS for V ˙ O 2 max (8.7%, 18.8%, 34.6%, respectively), V ˙ O 2 / HR (9.5%, 15.0%, 28.6%), VT1 (9.6%, 19.6%, 34.6%), VT2 (21.8%, 32.4%, 56.7%), Q ˙ max (8.2%, 16.9%, 28.8%), stroke volume (7.9%, 15.2%, 23.5%), peak power output (20%, 22%, 37.3%), average power output (21.1%, 21.3%, 32.5%), testosterone (52.9%, 61.6%, 59.9%), and testosterone-to-cortisol ratio (55.1%, 59.5%, 57.8%). Conclusions: Supramaximal HIIT performed at Δ%20ASR resulted in more uniform physiological adaptations than HIIT interventions prescribed using VIFT or MAS. Although hormonal changes do not follow this approach, all the approaches induced an anabolic effect. [ABSTRACT FROM AUTHOR]

Purpose: This study examined performance and physiological adaptations following 3 weeks of repeated-sprint training (RST) with blood-flow restriction (BFR) or without (non-BFR). Methods: Twenty-six semiprofessional and amateur adult male team-sport players were assessed for repeated-sprint ability, anaerobic capacity, leg lean mass, neuromuscular function, and maximal aerobic capacity before and after RST. Participants completed 9 cycling RST sessions (3 sets of 5–7 × 5-s sprints, 25-s passive recovery, 3-min rest) over a 3-week period with BFR or non-BFR. Results: During RST sessions, the BFR group demonstrated lower mean power output compared with non-BFR (−14.5%; g = 1.48; P =.001). Significant improvements (P <.05) in mean and peak power output during repeated-sprint ability (+4.1%; g = 0.42, and + 2.2%; g = 0.25, respectively) and anaerobic capacity (+4.8%; g = 0.47, and + 4.7%; g = 0.32, respectively) tests, leg lean mass (+2.0%; g = 0.16), and peak aerobic power (+3.3%; g = 0.25) were observed from pretesting to posttesting without any between-groups differences. No significant changes (P >.05) were observed for maximal isometric voluntary contraction and maximal aerobic capacity. Peak rate of force development decreased (P =.003) in both groups following RST (−14.6%; g = 0.65), without any between-groups differences. Conclusions: Repeated-sprint ability, anaerobic capacity, leg lean mass, and peak aerobic power improved following 3 weeks of RST; however, the addition of BFR did not further enhance adaptations. Interestingly, comparable improvements were achieved between groups despite lower external loads experienced during RST sessions with BFR. [ABSTRACT FROM AUTHOR]

Purpose: To investigate differences in time to exhaustion (TTE), O2 uptake ( V ˙ O 2 ), and accumulated O2 deficit ( O 2 def ) between competitive and recreational cross-country (XC) skiers during an intermittent-interval protocol standardized for maximal aerobic power (MAP). Methods: Twelve competitive (maximal V ˙ O 2 [ V ˙ O 2 max ] = 76.5 ± 3.8 mL · kg − 1 · min − 1 ) and 10 recreational ( V ˙ O 2 max = 63.5 ± 6.3 mL · kg − 1 · min − 1 ) male XC skiers participated. All tests were performed on a rollerski treadmill in the V2 ski-skating technique. To quantify MAP and maximal accumulated oxygen deficit (MAOD), the skiers performed a steady-state submaximal test followed by a 1000-m time trial. After a 60-minute break, TTE, V ˙ O 2 , and accumulated O 2 def were measured during an intermittent-interval protocol (40-s work and 20-s recovery), which was individually tailored to 120% and 60% of each subject's MAP. Results: During the 1000-m time trial, the competitive skiers had 21% (95% CI, 12%–30%) shorter finish time and 24% (95% CI, 14%–34%) higher MAP (all P <.01) than the recreational skiers. No difference was observed in relative exercise intensity (average power/MAP; P =.28), MAOD (P =.18), or fractional utilization of V ˙ O 2 max. During the intermittent-interval protocol, the competitive skiers had 34% (95% CI, 3%–65%) longer TTE (P =.03) and accumulated 61% (95% CI, 27%–95%) more O 2 def (P =.001) than the recreational skiers during work phases. Conclusions: Competitive XC skiers have longer TTE and accumulate more O 2 def than recreational XC skiers during an intermittent-interval protocol at similar intensity relative to MAP. This implies that performance in intermittent endurance sports is related to the ability to repeatedly recharge fractions of MAOD. [ABSTRACT FROM AUTHOR]

This article comments on a recent study about high-intensity interval training (HIIT) and its methodological problems. The authors agree with the study's identification of issues in research on the affective responses to HIIT but argue that the study's guidance on quantifying exercise intensity during HIIT is flawed. They propose using a percentage of peak workload during an incremental test as a more appropriate measure of exercise intensity. The authors also criticize the use of heart rate as a measure of intensity during interval exercise and suggest using metabolic landmarks instead. They provide examples from other studies to support their argument. Additionally, they refute criticisms regarding the appropriateness of HIIT intensities in studies comparing affective and enjoyment responses. [Extracted from the article]

Background: The osteoclastogenesis RANKL gene plays a key role in bone remodeling. The hypomethylation of its promoter region may cause osteoporosis. The present study aimed to elucidate the influence of physical activity on DNA methylation changes of RANKL promoter cytosine-phosphate-guanine (CpG)-rich region in active and sedentary adults and to assess the effect of aerobic and strength training on RANKL DNA methylation changes among Tunisian-North African adults. Methods: A total of 104 participants including 52 adults (58% males and 42% females) and 52 adults (31% males and 69% females) were recruited for the observational and interventional part of the study, respectively. The intervention consisted of 12 weeks of aerobic training (30 min/session) followed by 10 minutes of strengthening exercises. All participants completed the International Physical Activity Questionnaire and provided blood samples for quantitative methylation-specific polymerase chain reaction (PCR) analysis. Results: The study revealed a significant difference (P = 6 × 10−10) in the methylation level of the RANKL promoter region between active and sedentary adults, with a 6.68-fold increase observed in the active group. After the intervention, both the trained (P = 41 × 10−5) and untrained (P =.002) groups displayed high methylation levels in the RANKL promoter region. In addition, the trained group exhibited significant improvements in heart rate (P = 2.2 × 10−16), blood pressure (P = 39 × 10−3), maximal oxygen uptake (P = 1.5 × 10−7), and fat mass (P = 7 × 10−4). Conclusion: Exploring epigenetic modifications in the RANKL promoter region may contribute to a more comprehensive understanding of the complexity of osteoporosis. This suggests that aerobic/strength training could potentially improve the bone system, reducing its vulnerability to osteoporosis by increasing RANKL DNA methylation. [ABSTRACT FROM AUTHOR]

Purpose: This study examined differences in measures of health-related physical fitness in adolescents before and after extended school closures due to COVID-19. Method: The sample consisted of 298 students (135 males and 163 females) from a laboratory high school. Data were collected through FITNESSGRAM assessments. A repeated-measures multivariate analysis of covariance was calculated to analyze differences in fitness before and after COVID-19 closures, including McNemar–Bowker and McNemar tests. Results: Statistically significant differences were identified for Progressive Aerobic Capacity Endurance Run (−4.2%; 1.8 ml·kg−1·min−1) and curl-up (−12.5%; 7.9 repetitions). In addition, 18.8% fewer students were classified within the Healthy Fitness Zone for Progressive Aerobic Capacity Endurance Run, 4% for curl-up, 10.8% for push-up, and 6.4% for sit and reach. Conclusion: Results of this study demonstrate that there was a significant decline in physical fitness for secondary students during extended school closures and social isolation as a result of COVID-19. [ABSTRACT FROM AUTHOR]

Sex-related differences in changes in functional fitness over time were longitudinally assessed in older adults participating in a group-based multimodal exercise program. From a database, functional fitness scores were obtained for 89 older adults (71.6 ± 6.5 years old) who had completed two assessments, 5–8 years apart. Lower body strength, upper body strength, aerobic endurance, flexibility, and change of direction performances were compared over time and with normative values. Females (p =.02), but not males, had an improvement in upper body strength over time. Females were also more flexible than males at both assessments (p ≤.02). Of those who had five consecutive assessments, females were more flexible than males (p ≤.05) and had a faster change of direction ability (p <.001). When compared with normative values, our results indicate that typical time-related functional fitness loss can be attenuated with group exercise. Our results further support the need to tailor exercise prescription according to the individual. [ABSTRACT FROM AUTHOR]

It has been suggested that time spent at a high fraction of maximal oxygen consumption (%V˙ $\dot{\mathrm{V}}$O2max) plays a decisive role for adaptations to interval training. However, previous studies examining how interval sessions should be designed to achieve a high %V˙ $\dot{\mathrm{V}}$O2max have exclusively been performed in males. The present study compared the %V˙ $\dot{\mathrm{V}}$O2max attained during three different 6 × 8 min interval protocols, in female (n = 11; V˙ $\dot{\mathrm{V}}$O2max, 62.5 (6.4) mL · min−1·kg−1) and male (n = 8; V˙ $\dot{\mathrm{V}}$O2max, 81.0 (5.2) mL · min−1·kg−1) cyclists. Mean power output during work intervals were identical across the three interval protocols, corresponding to the cyclist's 40 min maximal effort (PO40min): (1) 30 s intervals at 118% of PO40min interspersed with 15 s active recovery at 60% (30/15), (2) constant pace at 100% of PO40min (CON), and (3) altering between 60 s intervals at 110% and 60 s at 90% of PO40min (60/60). Additionally, the study explored whether the m. vastus lateralis characteristics of the cyclists (fiber type proportion, capillarization, and citrate synthase activity) were associated with the %V˙ $\dot{\mathrm{V}}$O2max attained during the interval sessions. Overall, mean %V˙ $\dot{\mathrm{V}}$O2max and time ≥90% of V˙ $\dot{\mathrm{V}}$O2max were higher during 30/15 compared to CON (86.7 (10.1)% and 1123 (787) s versus 85.0 (10.4)% and 879 (779) s, respectively; both p ≤ 0.01) and 60/60 (85.6 (10.0)% and 917 (745) s, respectively; both p ≤ 0.05), while no difference was observed between 60/60 and CON (both p ≥ 0.36). During interval sessions, %V˙ $\dot{\mathrm{V}}$O2max and time ≥90% of V˙ $\dot{\mathrm{V}}$O2max did not differ between sexes. Skeletal muscle characteristics were not related to %V˙ $\dot{\mathrm{V}}$O2max during interval sessions. In conclusion, well‐trained cyclists demonstrate highest %V˙ $\dot{\mathrm{V}}$O2max during 30/15, irrespective of sex and skeletal muscle characteristics. [ABSTRACT FROM AUTHOR]

Rationale Aims Methods Results Conclusions Exercise capacity declines with age. However, the effect of common geriatric symptoms, that are related to physical performance, on exercise capacity is unclear.The study aimed to determine the impacts of sarcopenia, frailty, balance, and depression on both overall and abnormal exercise capacity.One hundred and nineteen community‐dwelling older adults over 65 years of age were included in the cross‐sectional study. Sarcopenia and frailty status were determined according to the “European Working Group on Sarcopenia in Older People2” and “Fried frailty criteria”, respectively. Exercise capacity, balance and depression were assessed with the 6‐min walk test (6MWT), the Timed Up and Go Test (TUG) and the Geriatric Depression Scale (GDS), respectively.Of the participants, 5% were sarcopenic, 32.8% were frail, and 29.4% had abnormal exercise capacity (6MWT < 82% pred). According to multivariate linear regression analysis, the model consisting of sarcopenia, frailty, TUG and GDS was explained 53% of the variation in 6MWT (R = 0.73, R2 = 0.53, p < 0.001), and all variables except GDS were independent predictors of exercise capacity (p < 0.05). Sarcopenia was the strongest predictor of 6MWT (β =−79.76, p = 0.011). The model including sarcopenia, TUG, frailty, and GDS provided 29% prediction of abnormal exercise capacity (Nagelkerke R2 = 29.7, p < 0.001), while TUG was the sole significant predictor in the model (Odd Ratio:1.32, p < 0.002), according to logistic regression analysis.This study indicates that changes in exercise capacity are more influenced by the presence of sarcopenia, and that poor TUG performance is the greatest risk factor for the impaired exercise capacity. [ABSTRACT FROM AUTHOR]

Background: It is internationally known that our population is aging. At the same time, some patients with COVID-19, due to their symptoms, required mechanical ventilation (MV) and subsequent pulmonary rehabilitation (PR). This study aimed to compare the effects of a multimodal PR program "ADULT" versus "OLDER" people with COVID-19 who were on MV. Methods: The intervention consisted of an 8-week hybrid PR program (2x week). Forced vital capacity (FVC) was measured at the beginning and end of PR, upper and lower limb strength was obtained through hand grip strength (HGS) and the sit-to-stand test (STST), respectively, and functional exercise capacity was measured with the 6-minute walking test (6MWT). Results: The main results were an increase in the FVC in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.27), an increase in HGS in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.52), in the same way, the number of repetitions on the STST increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.55). Finally, the distance covered on the 6MWT increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.65). Conclusions: The PR program is an effective strategy to improve FVC, muscle strength, and functional exercise capacity similarly in adults and older people with post severe COVID-19 who required MV. [ABSTRACT FROM AUTHOR]

Background: The single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) is available for maintenance therapy of chronic obstructive pulmonary disease (COPD). Cardinal features of COPD are lung hyperinflation and reduced exercise capacity. TRIFORCE aimed to evaluate the effect of BDP/FF/G on lung hyperinflation and exercise capacity in patients with COPD. Methods: This double-blind, randomised, active- and placebo-controlled, crossover study recruited adults with COPD aged ≥ 40 years, who were hyperinflated and symptomatic, and were receiving mono- or dual inhaled maintenance COPD therapy. In the three treatment periods, patients were randomised to receive BDP/FF/G, BDP/FF, or placebo, each for 3 weeks, with a 7–10-day washout between treatment periods. Assessments included slow inspiratory spirometry (for resting inspiratory capacity [IC]) and constant work-rate cycle ergometry (for dynamic IC and exercise endurance time). The primary objective was to compare BDP/FF/G and BDP/FF vs. placebo for resting IC at Week 3. Key secondary objectives were to compare BDP/FF/G and BDP/FF vs. placebo for dynamic IC and exercise endurance time during constant work rate cycle ergometry at Week 3. Results: Of 106 patients randomised, 95 completed the study. Resting IC adjusted mean differences vs. placebo were 315 and 223 mL for BDP/FF/G and BDP/FF, respectively (p < 0.001 for both). Adjusted mean differences vs. placebo for the key secondary endpoints were: 245 mL for dynamic IC (p < 0.001) and 69.2 s for exercise endurance time (nominal p < 0.001) with BDP/FF/G, and 96 mL (p = 0.053) and 70.1 s (nominal p < 0.001) with BDP/FF. Differences between BDP/FF/G and BDP/FF for resting and dynamic IC were 92 and 149 mL (p < 0.01 for both). All three treatments were generally well tolerated, with 27.3%, 25.3% and 19.0% of patients reporting adverse events with BDP/FF/G, BDP/FF and placebo, respectively, all mild or moderate. Conclusions: In patients with COPD, BDP/FF/G provided significant and clinically relevant improvements vs. placebo and BDP/FF in static and dynamic hyperinflation, with an improvement vs. placebo in exercise endurance. Trial registration: ClinicalTrials.gov (NCT05097014), registered 27th October 2021. [ABSTRACT FROM AUTHOR]

The article provides a historical account of the Scandinavian involvement in the 'Zuntz-Chauveau controversy' regarding skeletal muscle fuel utilization during exercise. It discusses the research efforts of Scandinavian scientists, including Christensen, Nielsen, and Asmussen, and their contributions to understanding skeletal muscle metabolism. The controversy centered on whether carbohydrates are the exclusive substrate for muscle metabolism during exercise, with various scientists proposing different theories. The article highlights the challenges faced by researchers, such as dietary interventions and health issues, in conducting experiments to determine the role of carbohydrates and fats in muscle energy turnover. [Extracted from the article]

Background: Pseudomonas aeruginosa (PA) isolation in patients with chronic obstructive pulmonary disease (COPD) has been associated with a poor prognosis. This meta-analysis aimed to determine significant risk factors for PA isolation among patients with COPD. Methods: A systematic literature retrieval from PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) was conducted, including studies from January 2003 to September 2024. Case-control and cohort studies exploring the risk factors for PA isolation in patients with COPD were included in this analysis. A random-effects model was applied to estimate the pooled adjusted odds ratio (paOR) or hazard ratio (paHR) with the corresponding 95% confidence intervals (CI). Results: Thirteen eligible studies with a total of 25,802 participants were included in this meta-analysis. Prior systemic steroid therapy (paOR: 2.67; 95% CI: 1.29–5.53; P = 0.008), previous antibiotic treatment (paOR: 2.83; 95% CI: 1.14–6.97; P = 0.02), high "Body mass index, airflow Obstruction, Dyspnea, Exercise capacity" (BODE) index (paOR: 4.13; 95% CI: 1.67–10.23; P = 0.002), 6-min walking distance (6MWD) < 250 m (paOR: 4.27; 95% CI: 2.59–7.01; P < 0.001), COPD assessment test (CAT) score > 20 points (paOR: 2.49; 95% CI: 1.46–4.23; P = 0.001), hypoproteinemia (paOR: 2.62; 95%CI: 1.32–5.19; P = 0.006), hospitalizations in the previous year (paOR: 3.74; 95%CI: 1.22–11.49; P = 0.021), Bronchiectasis (paOR = 4.81; 95% CI: 3.66–6.33; P < 0.001) and prior PA isolation (paOR: 16.39; 95% CI: 7.65–35.10; P < 0.001) were associated with PA isolation in patients with COPD. Conclusions: Our study identified nine risk factors associated with an increased risk of PA isolation in COPD patients. These findings are significant for the early identification of patients at risk for PA isolation, which might contribute to reducing mortality and improving clinical outcomes. [ABSTRACT FROM AUTHOR]

Background People with HIV (PWH) have lower exercise capacity than peers without HIV, which may be explained by chronotropic incompetence, the inability to increase heart rate during exercise. Methods The Exercise for Healthy Aging Study included adults aged 50 to 75 years with and without HIV. Participants completed 12 weeks of moderate-intensity exercise, before randomization to moderate or high intensity for 12 additional weeks. We compared adjusted heart rate reserve (AHRR; chronotropic incompetence <80%) on cardiopulmonary exercise testing by HIV serostatus and change from baseline to 12 and 24 weeks using mixed effects models. Results Among 32 PWH and 37 controls (median age, 56 years; 7% female), 28% of PWH vs 11% of controls had chronotropic incompetence at baseline (P =.067). AHRR was lower among PWH (91% vs 101%; difference, 10%; 95% CI, 1.9%–18.9%; P =.02). At week 12, AHRR normalized among PWH (+8%; 95% CI, 4%–11%; P <.001) and was sustained at week 24 (+5%; 95% CI, 1%–9%; P =.008) versus no change among controls (95% CI, −4% to 4%; P =.95; interaction P =.004). After 24 weeks of exercise, 15% of PWH and 10% of controls had chronotropic incompetence (P =.70). Conclusions Chronotropic incompetence contributes to reduced exercise capacity among PWH and improves with exercise training. [ABSTRACT FROM AUTHOR]

Exercise intolerance and exertional dyspnoea are hallmarks of fibrosing interstitial lung disease (FILD) and are associated with worse prognosis and quality of life. Activation of pulmonary vagal afferents influences the ventilatory pattern and contributes to the sensation of dyspnoea. We tested the hypothesis that nebulized fentanyl, which might attenuate aberrant pulmonary afferent activity in FILD, reduces ventilation and dyspnoea while extending exercise endurance time (EET). In this randomized, single‐blind, placebo‐controlled study, eight FILD patients (two males, 71 ± 6 years of age) performed incremental cardiopulmonary cycle exercise tests following nebulization of either fentanyl citrate (100 µg) or 0.9% saline. Previous work indicated that this dose was unlikely to produce central effects. Comparisons between treatment conditions at rest were undertaken using Student's paired t‐test, and exercise data were evaluated with two‐way ANOVA with repeated measures. Dyspnoea was assessed using the Borg dyspnoea scale. Resting respiratory variables were not different following treatment with fentanyl and saline; however, resting heart rate was lower following fentanyl (P = 0.002) and remained lower throughout exercise compared with placebo (P = 0.008). Fentanyl did not increase EET (placebo 334 ± 117 s vs. fentanyl 348 ± 126 s, P = 0.250) although overall minute ventilation was reduced slightly (mean difference: −0.97 L/min, P = 0.022). There were no differences in ratings of dyspnoea intensity or unpleasantness between the conditions either at rest or at end‐exercise. Nebulized fentanyl did not improve EET or exercise dyspnoea but did decrease minute ventilation during exercise, although the extent of this reduction appears clinically insignificant. These findings suggest that nebulized fentanyl is unlikely to offer significant benefits for enhancing exercise capacity in FILD. [ABSTRACT FROM AUTHOR]

It has been suggested that time at a high fraction (%) of maximal oxygen uptake (VO2max) plays a decisive role for adaptations to interval training. Yet, no study has, to date, measured the % of VO2max during all interval sessions throughout a prolonged training intervention and subsequently related it to the magnitude of training adaptations. Thus, the present study aimed to investigate the relationship between % of VO2max achieved during an interval training intervention and changes in endurance performance and its physiological determinants in well‐trained cyclists. Twenty‐two cyclists (VO2max 67.1 (6.4) mL·min−1 ·kg−1; males, n = 19; females, n = 3) underwent a 9‐week interval training intervention, consisting 21 sessions of 5 × 8‐min intervals conducted at their 40‐min highest sustainable mean power output (PO). Oxygen uptake was measured during all interval sessions, and the relationship between % of VO2max during work intervals and training adaptations were investigated using linear regression. A performance index was calculated from several performance measures. With higher % of VO2max during work intervals, greater improvements were observed for maximal PO during the VO2max test (R2adjusted = 0.44, p = 0.009), PO at 4 mmol·L−1 [blood lactate] (R2adjusted = 0.25, p = 0.035), the performance index (R2adjusted = 0.36, p = 0.013), and VO2max (R2adjusted = 0.54, p = 0.029). Other measures, such as % of maximal heart rate, were related to fewer outcome variables and exhibited poorer session‐to‐session repeatability compared to % of VO2max. In conclusion, improvements in endurance measures were positively related to the % of VO2max achieved during interval training. Percentage of VO2max was the measure that best reflected the magnitude of training adaptations. [ABSTRACT FROM AUTHOR]

Background: Higher prevalence rates of diabetes and its complications have been reported among individuals with poor physical activity and a sedentary lifestyle. This study explored the influence of six months of moderate-intensity supervised aerobic training on the serum lipid profile, hs-CRP level, and variable-related correlations in prediabetic and type 2 diabetes patients (T2DM). Design: The study was based on a two-arm parallel group pretest‒posttest comparative design. Methods: A total of 50 subjects who were diagnosed with diabetes for more than five years and aged 30–70 years were included in this study. The subjects were classified into two groups on the basis of their glycated haemoglobin (HbA1c%) values: Group 1 (patients with the prediabetes; HbA1c % ≤ 6.5, n = 25) and Group 2 (patients with the T2DM; HbA1c % ≥ 6.5, n = 25). Blood sugar, HbA1c %, insulin, lipid profile, and highly sensitive CRP (hs-CRP) were measured via colorimetric and immunoassay techniques at baseline and six months postintervention with moderate aerobic exercise. Results: The results revealed that participation in moderate aerobic training interventions for six months resulted in a significant reduction in BMI, fasting blood sugar, glycosylated haemoglobin, hs-CRP, and lipid profile parameters such as T-Cholest, TG, and LDL-C as well as significant improvement in the level of insulin with a reduction in the values of HOMA-IR towards normal values in the patients with prediabetes (P < 0.01) in group 1 and patients with diabetes in group 2 (P < 0.001). The change in VO2max with good physical fitness significantly improved with the exercise program after six months. The reduced levels of hs-CRP, HOMA-IR, and lipid profile and improved levels of insulin were significantly positively correlated with the levels of glycated haemoglobin (HbA1c%) in the patients with prediabetes (P < 0.01) and those with diabetes (P < 0.001) following six months of moderate aerobic training interventions. Moreover, hs-CRP was positively correlated with T-Cholest, TG, and LDL-C (p = 0.01) and negatively correlated with HDL-C. The data revealed improved glycemic control factors, lipid profiles, and hs-CRP levels as cardio-predictive markers in patients with both prediabetes and diabetes as well. These findings suggest that the anti-inflammatory effect of physical activity gained from moderate exercise training for six months may counteract increased cardiovascular complications associated with increased CRP levels and lipid profiles in prediabetes and T2DM patients. Conclusions: Moderate aerobic training for six months favourably affects glycemic parameters, lipid profiles, and inflammatory hs-CRP indicators and improves VO2max, an indicator of physical fitness, in prediabetic and diabetic patients. The data obtained suggest the positive effect of moderate exercise training as a protective modulator of cardiovascular disorders, including the dyslipidaemic profile, glycaemic control, and hs-CRP inflammatory markers, in prediabetes and T2DM patients. Thus, regular exercise, owing to its anti-inflammatory effects and ability to improve cardiorespiratory fitness, lipid profiles, blood glucose levels, and insulin resistance, may help reduce the severity of cardiovascular diseases in prediabetes and T2DM patients and healthy controls. Trial registration: Retrospectively registered with ClinicalTrials.gov PRS under trial identifier ID: NCT06246435 dated 30/01/2024. [ABSTRACT FROM AUTHOR]

Introduction: Prolonged and repeated exercise performed during an ultraendurance event can induce general and cardiac fatigue known as exerciseinduced cardiac fatigue. Our objective was to find a possible correlation between the cardiac function and the autonomic cardiac function. Methods: During a multistage ultra-endurance event, a female well-trained cyclist underwent daily rest echocardiography and heart rate variability measurements to assess the cardiac function and the cardiac autonomic function. Results: The athlete completed 3,345 km at 65% of her maximum heart rate and 39% of her maximum aerobic power. A progressive improvement of the systolic function for both the left ventricle and the right ventricle was observed during the event. Discussion: Alterations were observed on the cardiac autonomic function with an imbalance between sympathetic and parasympathetic, but there was no sign of a significant correlation between the cardiac function and the autonomic cardiac function and no signs of cardiac fatigue either. Further analysis should be performed on a larger sample to confirm the obtained results. [ABSTRACT FROM AUTHOR]

In this study, strenuous forced exercise caused intestinal damage and reduced the exercise capacity of mice. However, the antioxidant and anti-inflammatory properties of Lactobacillus pentosus CQZC02 (LPCQZC02) were found to improve both the intestinal barrier and exercise function in mice. The effectiveness of LPCQZC02 was confirmed through various methods, including kit detection, pathological observation, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and intestinal flora analysis. The findings demonstrated that LPCQZC02 could control colonic index, lessen colonic enlargement caused by intense exercise, and extend the running duration of mice. Serum levels of total superoxide dismutase (T-SOD), glutathione (GSH), and interleukin-10 (IL-10) were elevated, whereas those of malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a) were reduced. The findings of the mRNA expression analysis revealed that in the colons of mice who remarkably exercised, LPCQZC02 could increase the expression levels of zonula occludens-1 (ZO-1), occludin-1, and claudin-1 genes. Additionally, in skeletal muscle tissue, it could downregulate TNF-a expression level and upregulate copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese superoxide dismutase (Mn-SOD) expression levels. Furthermore, LPCQZC02 could both reduce and promote beneficial bacteria in the intestines of mice undergoing intense exercise. In conclusion, LPCQZC02 emerged as a functional probiotic and demonstrated a notable advantage over sulfasalazine, a medication for intestinal conditions, in mitigating oxidative inflammation, repairing intestinal barrier damage, and enhancing motor function in mice subjected to strenuous exercise. [ABSTRACT FROM AUTHOR]

The aim of the study is to investigate the association of cardiorespiratory fitness (CRF) and muscular strength indicators with gray matter volume (GMV) and to study whether fitness‐related regions of GMV are associated to executive function (EF) in cognitively normal older adults. Ninety‐one cognitively normal older adults (71.69 ± 3.91 years; 57.14% females) participated in this study from the AGUEDA trial. CRF was measured by a 2‐km walking test and a 6‐min walking test. Muscular strength was measured by handgrip, biceps curl, squats, and isokinetic strength tests. T1‐weigthed images were obtained through a magnetic resonance scan. GMV was determined by voxel‐based morphometric analysis. Standardized EF tests were performed. CRF did not show any positive association with GMV. Handgrip strength was positively associated with GMV (p < 0.001) in nine regions (β from 0.6 to 0.8 and k from 106 to 1927) and knee extension strength in three regions (β from 0.4 to 0.5 and k from 76 to 2776). Squats strength was negatively associated with GMV (p < 0.001) in two regions (β = −0.3, k = 1102 and k = 152) and the 2‐km walking test in one region (β = −0.4, k = 99). Only handgrip strength‐related GMV was associated with cognitive flexibility (p = 0.039, β = 0.215) and spatial working memory (p < 0.03, β 0.247–0.317), but not with EF score (p > 0.05). Muscular strength, but no CRF, may be positively related to GMV in cortical and subcortical regions, with implications for specific cognitive domains rather than the overall EF score. Specifically, handgrip strength was the indicator most associated with higher GMV, while squats strength and CRF were negatively related to GMV. ClinicalTrials.gov identifier: NCT05186090. [ABSTRACT FROM AUTHOR]

(1) Background: Exploring the relationship between spontaneous breathing patterns and aerobic and anerobic running exercise performance can greatly improve our understanding of optimizing physical fitness. Spontaneous breathing patterns refer to how the rhythm and depth of breathing affect performance and physical adaptation during exercise. (2) Methods: This study aimed to investigate this relationship by enrolling 240 college students (120 males and 120 females, aged 18–22). We evaluated their resting respiratory rate (RR), the combined total of abdominal and thoracic movements (AM+TM), the proportion of abdominal movement to the overall respiratory movement (AM/(AM+TM)), and the inhalation to exhalation ratio (I/E ratio). Additionally, their performance in a 50 m sprint (measuring anerobic capability), an 800- or 1000 m run (assessing mixed aerobic and anerobic capacity), and a 12 min distance run (evaluating aerobic capacity) was recorded. (3) Results: Our findings, through both correlational and comparative analyses, indicate that a larger AM+TM is predictive of a greater distance covered in the 12 min run, suggesting enhanced aerobic capacity. Interestingly, among female participants, a lower body mass index (BMI) coupled with a higher proportion of abdominal movement (AM/(AM+TM)) was linked to better performance in the 800 m run, indicative of superior mixed aerobic and anerobic capacities. These results imply that women with a larger tidal volume and those with a lower BMI but higher abdominal contribution to breathing at rest may exhibit better aerobic and mixed exercise capacities, respectively. (4) Conclusions: Based on these findings, we recommend that healthcare professionals and physical education instructors incorporate respiratory pattern assessments into their practices to potentially improve the physical health of their clients and students, with a particular emphasis on female populations. This study underscores the importance of understanding the intricate relationship between spontaneous respiratory patterns and exercise capabilities in enhancing overall physical fitness and health. [ABSTRACT FROM AUTHOR]

Physical activity and regular exercise are well known to reduce the risks of cerebrovascular and cardiovascular diseases, leading the American College of Sports Medicine to endorse the concept that "exercise is medicine". However, a single bout of exercise temporarily raises arterial blood pressure (BP) to meet the metabolic demands of working muscle, and this BP response is particularly exaggerated in older adults and patients with cardiovascular conditions, such as hypertension, resulting in an exaggerated BP response during exercise. This presents a paradox: while regular exercise is crucial for preventing these diseases, excessively high BP responses during exercise could increase the risk of vascular damage. The mechanisms underlying this exaggerated BP response during exercise remain unclear, and effective exercise regimens for these populations have yet to be established. Currently, low-intensity exercise is recommended; however, its efficacy in disease prevention is uncertain. Notably, even among healthy individuals, there is significant variation in the BP response to exercise. Some healthy individuals, despite having normal resting BP, exhibit an exaggerated BP response during physical activity. Importantly, these individuals are often unaware that their BP becomes excessively elevated during physical activity. Repeated exposure to these heightened BP responses through regular physical activity may increase their long-term risk of cardiovascular disease. How can we prevent disease development in these individuals while still ensuring the effectiveness of exercise? Some studies have shown that individuals with a family history of hypertension may experience this phenomenon even in children and adolescents. Additionally, left ventricular hypertrophy contributes to an exaggerated BP response to exercise, suggesting a possible genetic influence. Conversely, other reports indicate that factors such as arterial stiffness, obesity, and low exercise capacity also contribute to this exaggerated response. Our recent preliminary data suggest that the cognitive benefits of exercise may be diminished in individuals who exhibit an exaggerated BP response during exercise. This implies that individuals with an exaggerated BP response, despite having normal resting BP, may not fully benefit from exercise. In this perspective paper, we review the physiological aspects of this phenomenon and explore strategies to address it. Additionally, we discuss BP responses in athletes within this content. Our goal is to prevent disease while maximizing the benefits of exercise for healthy individuals with an exaggerated BP response, as well as for elderly and cardiovascular patients. [ABSTRACT FROM AUTHOR]

Background: Intense exercise leads to neutrophil extracellular traps (NETs) formation, which triggers cell disintegration. NET, as well as other processes of apoptosis, necrosis, and spontaneous secretion, result in increased levels of cell-free DNA (cf-DNA) in the circulation. An increment of cf-DNA is also observed in autoimmune diseases, such as type 1 diabetes mellitus (T1DM). Repeated exhaustive exercises are an impulse for physiological adaptation; therefore, in this case–control study, we compared the exercise-induced increase in cf-DNA in men with T1DM and healthy controls to determine the development of the tolerance to exercise. Methods: Volunteers performed a treadmill run to exhaustion at a speed matching 70% of their personal VO2 max at three consecutive visits, separated by a 72 h resting period. Blood was collected before and after exercise for the determination of plasma cell-free nuclear and mitochondrial DNA (cf n-DNA, cf mt-DNA) by real-time PCR, blood cell count and metabolic markers. Results: Each bout of exhaustive exercise induced a great elevation of cf n-DNA levels. An increase in cf mt-DNA was observed after each run. However, the significance of the increase was noted only after the second bout in T1DM participants (p < 0.02). Changes in cf-DNA concentration were transient and returned to baseline values during 72 h of resting. The exercise-induced increment in circulating cf n-DNA and cf mt-DNA was not significantly different between the studied groups (p > 0.05). Conclusions: Cf-DNA appears to be a sensitive marker of inflammation, with a lower post-exercise increase in individuals with T1DM than in healthy men. [ABSTRACT FROM AUTHOR]

Background: The incremental exercise test is commonly used to measure maximal oxygen uptake (VO2max), but an additional verification test is often recommended as the "gold standard" to confirm the true VO2max. Therefore, the aim of this study was to compare the peak oxygen uptake (VO2peak) obtained in the ramp incremental exercise test and that in the verification test performed on different days at submaximal intensity. Additionally, we examined the roles of anaerobic performance and respiratory muscle strength. Methods: Sixteen physically active men participated in the study, with an average age of 22.7 ± 2.4 (years), height of 178.0 ± 7.4 (cm), and weight of 77.4 ± 7.3 (kg). They performed the three following tests on a cycle ergometer: the Wingate Anaerobic Test (WAnT), the ramp incremental exercise test (IETRAMP), and the verification test performed at an intensity of 85% (VER85) maximal power, which was obtained during the IETRAMP. Results: No significant difference was observed in the peak oxygen uptake between the IETRAMP and VER85 (p = 0.51). The coefficient of variation was 3.1% and the Bland–Altman analysis showed a high agreement. We found significant correlations between the total work performed in the IETRAMP, the anaerobic peak power (r = 0.52, p ≤ 0.05), and the total work obtained in the WAnT (r = 0.67, p ≤ 0.01). There were no significant differences in post-exercise changes in the strength of the inspiratory and expiratory muscles after the IETRAMP and the VER85. Conclusions: The submaximal intensity verification test performed on different days provided reliable values that confirmed the real VO2max, which was not limited by respiratory muscle fatigue. This verification test may be suggested for participants with a lower anaerobic mechanical performance. [ABSTRACT FROM AUTHOR]

Purpose: Moderate-intensity aerobic exercise is safe and beneficial in atrial fibrillation (AF) and coronary heart disease (CHD). Irregular or rapid heart rates (HR) in AF and other heart conditions create a challenge to using HR to monitor exercise intensity. The purpose of this study was to assess the potential of breathing frequency (BF) to monitor exercise intensity in people with AF and CHD without AF. Methods: This observational study included 30 AF participants (19 Male, 70.7 ± 8.7 yrs) and 67 non-AF CHD participants (38 Male, 56.9 ± 11.4 yrs). All performed an incremental maximal exercise test with pulmonary gas exchange. Results: Peak aerobic power in AF ( V ˙ O2peak; 17.8 ± 5.0 ml.kg−1.min−1) was lower than in CHD (26.7 ml.kg−1.min−1) (p <.001). BF responses in AF and CHD were similar (BF peak: AF 34.6 ± 5.4 and CHD 36.5 ± 5.0 breaths.min−1; p =.106); at the 1st ventilatory threshold (BF@VT-1: AF 23.2 ± 4.6; CHD 22.4 ± 4.6 breaths.min−1; p =.240). % V ˙ O2peak at VT-1 were similar in AF and CHD (AF: 59%; CHD: 57%; p =.656). Conclusion: With the use of wearable technologies on the rise, that now include BF, this first study provides an encouraging potential for BF to be used in AF and CHD. As the supporting data are based on incremental ramp protocol results, further research is required to assess BF validity to manage exercise intensity during longer bouts of exercise. [ABSTRACT FROM AUTHOR]

This article discusses the effectiveness of alpine altitude climate treatment (AACT) in improving asthma control for patients with severe uncontrolled asthma, regardless of whether they have used biologics or not. The study included adult patients with severe uncontrolled asthma who underwent AACT at a specialized clinic in Switzerland. The results showed that AACT led to significant improvements in asthma control, quality of life, exercise capacity, and inflammatory parameters for all patients, regardless of biologics use. Additionally, AACT allowed for a reduction in oral corticosteroid use in a significant number of patients. The study highlights the potential of AACT as a non-pharmacological treatment option for severe uncontrolled asthma. [Extracted from the article]

AbstractPurposeMethodsResultsConclusion\nIMPLICATIONS FOR REHABILITATIONTo examine the effects of inspiratory muscle training (IMT) on pulmonary and diaphragmatic function, exercise capacity, balance and quality of life (QOL), in post-stroke individuals.A literature search was conducted using MEDLINE, CINAHL, EMBASE, PubMed, PEDro, Web of Science and China Biological Medicine databases. Randomized controlled trials (RCTs) with a PEDro score ≥6 focusing on the effects of IMT were included. The GRADE system was used to determine the certainty of evidence for each outcome.Nine studies (255 participants) were included. IMT significantly increased forced expiratory volume in one second (FEV1) (4 studies, 112 participants, mean difference (MD)=0.18 litre, 95% confidence interval (CI): 0.14–0.23); maximal inspiratory pressure (MIP) (8 studies, 226 participants, MD = 6.37 cm H2O, 95% CI: 1.26–11.49); and diaphragm thickness fraction (DTf) on both sides (MD of affected side vs. unaffected side: 51 vs. 37%). The evidence certainty for diaphragmatic function was moderate. No significant change was observed in forced vital capacity (FVC), balance function, exercise capacity and QOL.This review reveals moderate evidence certainty in support of IMT improving diaphragmatic function. It appears that a training intensity between 30 and 50% MIP results in a significantly improved MIP.Stroke not only impacts motor function but also affects respiratory function, especially diaphragmatic function.Inspiratory muscle training (IMT) is an intervention that has been used to improve the strength and endurance of inspiratory muscles.There is evidence of moderate certainty which cautiously recommends IMT to improve diaphragmatic function after stroke.The evidence supporting IMT for the enhancement of forced vital capacity, balance function, exercise capacity and quality of life in stroke patients is inadequate. [ABSTRACT FROM AUTHOR]

Yoga is effective in binge eating disorder (BED) treatment, but it does not seem effective enough to improve low physical fitness. In contrast, high-intensity interval training (HIIT) is effective in improving physical fitness but has never been studied in the context of BED. In the study, 47 young inactive females with mild to moderate BED were recruited and randomly assigned to a HIIT group (HIIT), a Yoga group (YG), or a control group (CG; age, 19.47 ± 0.74, 19.69 ± 0.874, and 19.44 ± 0.63 years; BMI, 21.07 ± 1.66, 21.95 ± 2.67, and 20.68 ± 2.61 kg/m2, respectively). The intervention groups participated in 8-week specific exercises, while the CG maintained their usual daily activity. Before and after the training, participants were evaluated for BED using the binge eating scale (BES) and for physical fitness. The obtained data were compared within groups and between groups, and a correlation analysis between BES and physical fitness parameters was performed. After the training, the YG presented significant improvements in BES (− 20.25%, p = 0.006, ηp2 = 0.408), fat mass (FM, − 3.13%, p = 0.033, ηp2 = 0.269), and maximal oxygen consumption (VO2max, 11.51%, p = 0.000, ηp2 = 0.601), whereas the HIIT showed significant improvements in body weight (BW, − 1.78%, p = 0.006, ηp2 = 0.433), FM (− 3.94%, p = 0.033, ηp2 = 0.285), and BMI (− 1.80%, p = 0.006, ηp2 = 0.428), but not in BES. Comparisons between groups revealed that both HIIT and YG had significantly higher VO2max levels than CG (HIIT 12.82%, p = 0.006, ηp2 = 0.088; YG: 11.90%, p = 0.009, ηp2 = 0.088) with no difference between HIIT and YG. Additionally, YG presented significantly lower BES than both HIIT (15.45%, p = 0.02, ηp2 = 0.03) and CG (11.91%, p = 0.022, ηp2 = 0.03). In conclusion, Yoga is an effective treatment for BED, but HIIT is not, despite its high efficacy in improving physical fitness. [ABSTRACT FROM AUTHOR]

This research examined the impact of aerobic exercise intensity and dose on acute post‐exercise cerebral shear stress and blood flow. Fourteen young adults (27 ± 5 years of age, eight females) completed a maximal oxygen uptake (V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$) treadmill test followed by three randomized study visits: treadmill exercise at 30% of V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ for 30 min, 70% of V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ for 30 min and 70% of V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ for a duration that resulted in caloric expenditure equal to that in the 30% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ visit (EqEE). A venous blood draw and internal carotid artery (ICA) ultrasound were collected before and immediately following exercise. ICA diameter and blood velocity were determined using automated edge detection software, and blood flow was calculated. Using measures of blood viscosity, shear stress was calculated. Aerobic exercise increased ICA shear stress (time: P = 0.005, condition: P = 0.012) and the increase was greater following exercise at 70% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ (∆4.1 ± 3.5 dyn/cm2) compared with 30% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ (∆1.1 ± 1.9 dyn/cm2; P = 0.041). ICA blood flow remained elevated following exercise (time: P = 0.002, condition: P = 0.010) with greater increases after 70% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ (Δ268 ± 150 mL/min) compared with 30% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ (∆125 ± 149 mL/min; P = 0.041) or 70% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}\max }}$ EqEE (∆127 ± 177 mL/min; P = 0.004). Therefore, aerobic exercise resulted in both intensity‐ and dose‐dependent effects on acute post‐exercise ICA blood flow whereby vigorous intensity exercise provoked a larger increase in ICA blood flow compared to light intensity exercise when performed at a higher dose. What is the central question of this study?What are the independent and combined effects of exercise intensity and dose on post‐exercise internal carotid artery (ICA) haemodynamics?What is the main finding and its importance?The combined effects of exercise intensity and dose evoked the greatest haemodynamic response whereby vigorous intensity exercise for a longer duration resulted in the greatest increase in post‐exercise ICA blood flow. Therefore, exercise intensity and dose are important considerations for utilizing exercise to improve cerebrovascular function. [ABSTRACT FROM AUTHOR]

Background: Physical inactivity, which is highly prevalent in patients with systemic lupus erythematosus (SLE), is an independent risk factor for cardiovascular events and causes many complications. This study aimed to investigate the effect of objective measurement and physical activity level on peripheral muscle strength, exercise capacity, pain, dyspnea, fatigue, anxiety, and depression in patients with SLE. Methods: The present cross-sectional study analyzed 41 patients with SLE. Clinical and demographic characteristics of patients were recorded. Functional exercise capacity, peripheral muscle strength, dyspnea, pain, fatigue, anxiety, and depression were assessed. The physical activity level was assessed by a wearable activity tracker (Mi Band four smart band). Results: The number of steps measured by the activity tracker was 4384.43 ± 1558.21 steps per day in patients with SLE. Patients with physical activity levels below 5000 steps exhibited elevated levels of fatigue, along with diminished functional exercise capacity and knee muscle strength, in comparison to those who were above the 5000-step threshold. Physical activity levels correlated with functional exercise capacity (6MWT), physiological parameters (maximum heart rate, Δ heart rate, Δ dyspnea, QFM fatigue, Δ QFM fatigue), and knee extension muscle strength. The functional exercise capacity and knee extension were identified as significantly and dependently associated with physical activity levels in SLE patients. Conclusion: Physical activity level is associated with functional exercise capacity and knee muscle strength in patients with SLE. [ABSTRACT FROM AUTHOR]

Aim: To investigate how delayed post‐exercise carbohydrate intake affects muscle glycogen, metabolic‐ and mitochondrial‐related molecular responses, and subsequent high‐intensity interval exercise (HIIE) capacity. Methods: In a double‐blind cross‐over design, nine recreationally active men performed HIIE (10 × 2‐min cycling, ~94% W˙peak) in the fed state, on two occasions. During 0–3 h post‐HIIE, participants drank either carbohydrates ("Immediate Carbohydrate" [IC], providing 2.4 g/kg) or water ("Delayed Carbohydrate" [DC]); total carbohydrate intake over 24 h post‐HIIE was matched (~7 g/kg/d). Skeletal muscle (sampled pre‐HIIE, post‐HIIE, +3 h, +8 h, +24 h) was analyzed for whole‐muscle glycogen and mRNA content, plus signaling proteins in cytoplasmic‐ and nuclear‐enriched fractions. After 24 h, participants repeated the HIIE protocol until failure, to test subsequent HIIE capacity; blood lactate, heart rate, and ratings of perceived effort (RPE) were measured throughout. Results: Muscle glycogen concentrations, and relative changes, were similar between conditions throughout (p > 0.05). Muscle glycogen was reduced from baseline (mean ± SD mmol/kg dm; IC: 409 ± 166; DC: 352 ± 76) at post‐HIIE (IC: 253 ± 96; DC: 214 ± 82), +3 h (IC: 276 ± 62; DC: 269 ± 116) and + 8 h (IC: 321 ± 56; DC: 269 ± 116), returning to near‐baseline by +24 h. Several genes (PGC‐1ɑ, p53) and proteins (p‐ACCSer79, p‐P38 MAPKThr180/Tyr182) elicited typical exercise‐induced changes irrespective of condition. Delaying carbohydrate intake reduced next‐day HIIE capacity (5 ± 3 intervals) and increased RPE (~2 ratings), despite similar physiological responses between conditions. Conclusion: Molecular responses to HIIE (performed in the fed state) were not enhanced by delayed post‐exercise carbohydrate intake. Our findings support immediate post‐exercise refueling if the goal is to maximize next‐day HIIE capacity and recovery time is ≤24 h. [ABSTRACT FROM AUTHOR]

Deep water running (DWR) is an exercise model often used for health promotion purposes. This study standardized an aerobic capacity evaluation protocol specific for attached DWR in young healthy adults and monitored a DWR session with normobaric hypoxia exposure addition. In study 1, nine young healthy adults, seven male and two female (22.88 ± 3.14 years old; 72.44 ± 11.38 kg; 174.88 ± 9 cm; 23.58 ± 2.33 kg m−2), were subjected to two DWR incremental tests with a 48-hour interval between them, and in study 2, six healthy males were subjected to three (hypoxia, normoxia, and inter-effort recovery hypoxia) attached DWR exercise sessions involving normobaric hypoxia. Data are expressed as average ± standard deviation. Friedman's test was used to compare the groups with a significance level of P < 0.05. In study 1, no significant statistical differences were observed for the physiological variables analyzed. In study 2, there was no difference in strength and lactate between conditions; values of rates of perceived exertion were higher in the hypoxic session, compared to inter-effort recovery hypoxia, in efforts 1 and 5, respectively, while heart rate was lower in effort 1 in normoxia. In hypoxia, effort 1 was lower than effort 3, with no alteration in recovery hypoxia. This aerobic capacity evaluation protocol is valid, sensitive, and replicable, and there were no important differences in the physiological variables from high-intensity exercise sessions monitoring in hypoxia, normoxia, and inter-effort recovery hypoxia conditions. [ABSTRACT FROM AUTHOR]

Cancer survivors exposed to anthracycline chemotherapy are at risk for developing cardiomyopathy, which may have delayed clinical manifestation. In a retrospective cross-sectional study, we evaluated the utility of cardiopulmonary exercise testing (CPET) for detecting early cardiac disease in 35 pediatric cancer survivors by examining the associations between peak exercise capacity (measured via percent predicted peak VO2) and resting left ventricular (LV) function on echocardiography and cardiac magnetic resonance imaging (cMRI). We additionally assessed the relationships between LV size on resting echocardiography or cMRI and percent predicted peak VO2 since LV growth arrest can occur in anthracycline-exposed patients prior to changes in LV systolic function. We found reduced exercise capacity in this cohort, with low percent predicted peak VO2 (62%, IQR: 53–75%). While most patients in our pediatric cohort had normal LV systolic function, we observed associations between percent predicted peak VO2 and echocardiographic and cMRI measures of LV size. These findings indicate that CPET may be more sensitive in manifesting early anthracycline-induced cardiomyopathy than echocardiography in pediatric cancer survivors. Our study also highlights the importance of assessing LV size in addition to function in pediatric cancer survivors exposed to anthracyclines. [ABSTRACT FROM AUTHOR]

After Fontan operation, decreased venous capacitance and venoconstriction are adaptive mechanisms to maintain venous return and cardiac output. The consequent higher venous pressure may adversely impact end-organ function, exercise capacity and result in worse clinical outcomes. This pilot study evaluated the safety and effect of isosorbide dinitrate (ISDN), a venodilator, on exercise capacity, peripheral venous pressure (PVP), and liver stiffness in patients with Fontan circulation. In this prospective single-arm trial, 15 individuals with Fontan circulation were evaluated at baseline and after 4 weeks of therapeutic treatment with ISDN. Primary aims were to assess the safety of ISDN and the effect on maximal exercise. We also aimed to evaluate the effect of ISDN on ultrasound-assessed liver stiffness, markers of submaximal exercise, and PVP at rest and peak exercise. Repeated measures t-tests were used to assess change in variables of interest in response to ISDN. Mean age was 23.5 ± 9.2 years (range 11.2–39.0 years), and 10/15 (67%) were male. There was no statistically significant change in peak VO2 (1401 ± 428 to 1428 ± 436 mL/min, p = 0.128), but VO2 at the anaerobic threshold increased (1087 ± 313 to 1115 ± 302 mL/min, p = 0.03). ISDN was also associated with a lower peak exercise PVP (22.5 ± 4.5 to 20.6 ± 3.0 mmHg, p = 0.015). Liver stiffness was lower with ISDN, though the difference was not statistically significant (2.3 ± 0.4 to 2.1 ± 0.5 m/s, p = 0.079). Of the patients completing the trial, mild headache was common (67%), but there were no major adverse events. Treatment with ISDN for 4 weeks is well-tolerated in patients with a Fontan circulation. ISDN is associated with an increase in VO2 at anaerobic threshold, lower peak PVP, and a trend toward lower liver stiffness. Larger, longer duration studies will be necessary to define the impact of ISDN on clinical outcomes in the Fontan circulation. Clinical Trial Registration: URL: https://clinicaltrials.gov. Unique identifier: NCT04297241. [ABSTRACT FROM AUTHOR]

Near-infrared spectroscopy (NIRS) can be used to demonstrate muscle metabolism and oxygenation. NIRS-based oximeters enable the noninvasive measurement of static and dynamic muscle oxygenation. This study aimed to evaluate the relationship between NIRS readings and exercise capacity in group E COPD patients. The prospective study included 40 patients with group E COPD who presented to our outpatient clinic between May 2021 and June 2022. The patients were evaluated with pulmonary function testing, 6-Minute Walk Test (6MWT), echocardiography, and dyspnea and quality of life assessments. NIRS muscle oxygen saturation (SmO2) levels at the start and end of the 6MWT were obtained. 6MWT distance was positively correlated with intercostal SmO2 and fingertip SO2 at the start (R = 0.679, p ≤ 0.001 and R = 0.321, p = 0.04, respectively) and end of the 6MWT (R = 0.693, p ≤ 0.001 and R = 0.635, p ≤ 0.001, respectively) and negatively correlated with the number of hospitalizations due to exacerbations in the last year and mean pulmonary arterial pressure (R = − 0.648, p ≤ 0.001 and R = − 0.676, p ≤ 0.001, respectively). SF-36 score was positively correlated with intercostal SmO2 at the beginning of the 6MWT (R = 0.336, p = 0.03). Intercostal SmO2 levels at the start of the 6MWT positively correlated with diffusing capacity of the lung for carbon dioxide (DLCO) (R = 0.388, p = 0.01) and ratio of DLCO to alveolar volume (DLCO/VA) levels (R = 0.379, p = 0.02), and these correlations persisted more strongly after the 6MWT (R = 0.524, p = 0.01; R = 0.500, p = 0.01, respectively). NIRS is a practical and noninvasive method for measuring muscle oxygenation and can be used as an alternative to 6MWT in the evaluation of exercise capacity in patients with group E COPD. [ABSTRACT FROM AUTHOR]

Validation of a Wrist-Worn Optical Heart Rate Monitor During Maximal Treadmill Exercise Testing. JEPonline 2024;27(5): 50-56. Heart rate (HR) watches using photoplethysmography (PPG) are a popular, portable, and practical alternative to electrocardiogram (ECG) for HR monitoring. The purpose of this study was to determine validity for a PPM watch for measuring HR during incremental treadmill exercise using ECG as the criterion. Twenty-two subjects (13 men, 9 women; 35.8 ± 6.3 yr) performed a Bruce treadmill protocol exercise test. HR was recorded at rest and each minute with the Mio Alpha PPM and ECG simultaneously. HR was compared between methods using paired-samples t-tests. Validity coefficients were determined using Pearson correlations. HR had a significant correlation between methods overall (r = 0.97). Significant correlations were observed for rest and each stage (r values from 0.67 to 0.96). HR was significantly different between methods for rest (ECG = 66 ± 13 b·min-1, Mio = 68 ± 16 b·min-1), stage 3 (ECG = 144 ± 13 b·min-1, Mio = 143 ± 13 b·min-1), stage 4 (ECG = 168 ± 13 b·min-1, Mio = 164 ± 14 b·min-1), and stage 5 (ECG = 178 ± 12 b·min-1, Mio = 173 ± 18 b·min-1). There was a strong agreement between the HR methods and mean differences did not exceed 3 b·min-1 except for stage 5. Therefore, a PPM watch may provide accurate HR monitoring at most exercise intensities. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the effects of combined training with maximal aerobic speed and small-sided games on football players' aerobic capacity development. Methods: The football players were divided into three groups as a combined training group (n = 20) (Mean ± SD age 23.40 ± 2.92 yrs, BMI was 23.67 ± 1.59 kg/m2, mass: 74.80 ± 5.46 kg, height: 177.73 ± 4.31 cm), maximal aerobic speed group (n = 20) (Mean ± SD age 23.93 ± 2.46 yrs, BMI was 23.32 ± 1.42 kg/m2, mass: 72.66 ± 5.38 kg, height: 176.46 ± 4.99 cm) and regular training group (n = 20) (Mean ± SD age 24.80 ± 5.84 yrs, BMI was 22.87 ± 1.67 kg/m2, mass: 73.06 ± 6.74 kg, height: 178.33 ± 7.98 cm). In addition to regular football training, maximal aerobic speed training with small-sided games was applied to the combined training group (CT) and only maximal aerobic speed training was applied to the maximal aerobic speed group (MAS) twice a week for 12 weeks. The normal training group (NT) continued their routine football training programme. All participants applied the Yo-Yo IR1 test in the pre-test and post-test of the study. As a result of normality tests, it was determined that the data showed normal distribution, and the ANOVA test and Tukey's multiple comparison test were used in the intergroup evaluation. Results: When the Yo-Yo IR1 Test pre-test and post-test results were analysed, maximal aerobic speed training with small-sided games (CT) and maximal aerobic speed (MAS) groups were significantly higher compared to the normal training (NT) group regarding training load, running distance, and VO2max value among the football players (p = 0.001). There was no difference in the normal training group (p > 0.05). As a result, it was determined that combined training with maximal aerobic speed, small-sided games, and only maximal aerobic speed effectively improved football players' aerobic capacity and general performance. [ABSTRACT FROM AUTHOR]

This study explores the association of respiratory muscle strength with aerobic endurance kinetics among athletes, with a specific focus on maximal oxygen consumption (VO2max). Previous research has elucidated the complex interactions between respiratory and skeletal muscles during exercise, highlighting the critical role of efficient respiration in maximizing athletic performance. The interplay between active skeletal muscles and respiratory muscles, especially the influence of respiratory muscle fatigue on exercise capacity, is well-documented. High-intensity exercise has been shown to activate the respiratory muscle metaboreflex, which can restrict blood flow to working muscles, thereby impacting the energy required for respiration. A total of 41 athletes, drawn from the disciplines of biathlon, judo, and cross-country, participated in this study. Respiratory function tests (RFTs) were administered to assess various respiratory parameters, including changes in chest circumference. Additionally, maximal oxygen consumption (VO2max) and heart rate were measured during a treadmill test. To explore the associations between VO2max and ventilatory parameters—namely, ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2)—as well as respiratory metrics, linear regression analysis was employed. Based on the standardized regression coefficients (β), it was found that maximum expiratory pressure (MEP) (mean ± SD: 130.95 ± 42.82) and inspiratory diaphragmatic circumference values were significantly associated with VE, VO2, and VCO2. Conversely, the other predictor variables did not exhibit a significant effect on VE (mean ± SD: 134.80 ± 36.69), VO2 (mean ± SD: 3877.52 ± 868.47 mL), and VCO2 (mean ± SD: 4301.27 ± 1001.07 mL). Similarly, measurements of chest circumference (mean ± SD: 91.40 ± 10.72 cm), MEP, and diaphragmatic circumference during inspiration (mean ± SD: 95.20 ± 10.21 cm) were significantly associated with VO2max (mean ± SD: 58.52 ± 10.74 mL/kg/min), while the remaining predictor variables did not demonstrate a significant effect on VO2max. Additionally, a multiple linear regression analysis was conducted to examine the combined effects of respiratory muscle strength and ventilatory factors on VO2max. The model, which included interaction terms, explained 89.9% of the variance in VO2max (R2 = 0.899, adjusted R2 = 0.859). Significant interactions were found between MIP and VE (B = −0.084, p = 0.006), as well as MEP and VE (B = 0.072, p = 0.012). These findings suggest that respiratory muscle strength plays a more substantial role in determining VO2max in individuals with higher ventilatory efficiency, highlighting the importance of both respiratory strength and breathing efficiency in aerobic performance. Our findings underscore the importance of considering respiratory muscle strength in assessing and enhancing athletes' aerobic performance. Integrating objective measurements such as maximal inspiratory and expiratory pressure assessments into routine performance evaluations allows coaches and sports scientists to monitor changes in respiratory function over time and adjust training protocols accordingly. [ABSTRACT FROM AUTHOR]

The aim of the study was to assess the influence of year-long training of race walkers on physiological cost and total energy center of mass (CoM). The assessment performed was based on indicating the differences between the resulting energy cost in a group of elite race walkers walking at technical, threshold, and racing speeds calculated by physiological and biomechanical methods before beginning and after finishing a year-long training cycle. The study involved 12 competitive race walkers who had achieved champion or international champion level. Their aerobic endurance was determined by means of a direct method, applying an incremental exercise test on the treadmill. The gait of the participants was recorded using the 3D Vicon analysis system. Changes in mechanical energy amounted to the value of the total external work of the muscles needed to accelerate and lift the center of mass during a normalized gait cycle. The highest influence on the total external work increase for increasing speeds of gait in both examinations was attributed to the changes in the kinetic energy resulting from the center of mass movement. A statistically significant decrease of the mean value of total external work for racing speed was observed in the second examination (p < 0.001). An approx. 8% decrease (NS) of EE energy cost, standardized by body mass and distance covered, was found between the first and second examinations. The energy cost and total external work were significantly differentiated by the walkers' gait speeds (p < 0.05–0.001). The energy cost significantly differed from the total external work at p < 0.001. [ABSTRACT FROM AUTHOR]

Background: Evidence regarding the performance-related effects of Actovegin is limited, despite legislated restrictions being in place for this supplement within sport settings. Objectives: Our study examined the effects of Actovegin on physiological responses and performance during maximal cardiopulmonary exercise in collegiate athletes. Methods: A randomized, double-blind, placebo-controlled experimental design was adopted. Moderately trained collegiate athletes from various sports were randomly allocated to placebo (n = 8) or Actovegin (n = 8) groups. All athletes consumed three capsules across each day for seven days of loading. Athletes underwent two separate cardiopulmonary exercise tests one week apart. Separate 2 × 2 mixed ANOVAs and effect sizes ( η p 2 ) were used to assess for between- and within-group differences. Results: A significant time * group effect (p = 0.036, η p 2 = 0.278) was observed in systolic blood pressure. Significant main effects were only observed for time in several variables, with increases in peak oxygen uptake (VO2) (p < 0.001, η p 2 = 0.893), peak minute ventilation (p = 0.004, η p 2 = 0.456), ventilatory equivalents for carbon dioxide (p = 0.002, η p 2 = 0.517), oxygen pulse (p = 0.006, η p 2 = 0.434), VO2 at first ventilatory threshold (p = 0.002, η p 2 = 0.520), velocity at second ventilatory threshold (p < 0.001, η p 2 = 0.997), VO2 at second ventilatory threshold (p < 0.001, η p 2 = 0.628), and peak velocity (p = 0.010, η p 2 = 0.386), and a decrease in respiratory exchange ratio (p < 0.001, η p 2 = 0.695). Conclusions: Our findings suggest that although physiological and performance alterations were evident with Actovegin supplementation during cardiopulmonary exercise, no further benefits beyond those obtained with a placebo were attained. [ABSTRACT FROM AUTHOR]

BACKGROUND: Law enforcement is a profession of sedentary physical activity interspersed with physically demanding activity that requires high levels of fitness. It is imperative that agencies training law enforcement recruits maximise their fitness during their time at the academy. OBJECTIVE: The aim of this study was to investigate changes in physical fitness during academy training. METHODS: Retrospective data for 10 academy recruit classes, totalling 715 participants, were collected from a US law enforcement agency. The change in performance on two standardised tests were used as outcome measures. Comparisons were made between percentiles utilising one-way ANOVA and a linear mixed model (LMM). RESULTS: Overall, higher percentiles were found to have smaller improvements in physical fitness than lower percentiles. The results of the LMM support this supposition, showing that lower physical fitness scores resulted in greater improvements in a generalised fitness assessment (value = –0.45, standard error 0.02, p < 0.001) and an occupational assessment (value = –0.49, standard error = 0.02, p < 0.001). CONCLUSION: The results of this study suggest that recruits with lower physical fitness will see greater improvements during academy training. This could be due to a ceiling effect for the more fit but may also be due to recruits of higher physical fitness being under trained during academy. Utilising ability-based training and prescribing an appropriate workload to recruits of higher fitness may improve overall recruit fitness upon graduation. [ABSTRACT FROM AUTHOR]

Background: This study aimed to compare the aerobic capacity in swimming, cycling and arm cranking in swimmers aged 11–13 years. Methods: Eleven swimmers (mean age, 12.1 ± 1.0 years) performed three incremental exercise tests. One of the tests was performed under specific conditions (front crawl swimming), and the other two were under non–specific conditions (cycling and arm cranking). Data on the pulmonary gas exchange were recorded using the portable analyser MetaMax 3B (Cortex, Leipzig, Germany). One-way analysis of variance for repeated measures was employed to test the null hypothesis and determine statistically significant differences between the indicators obtained under specific and non–specific testing conditions. Pearson's correlation coefficient was calculated to assess the relationships between the indicators of the pulmonary gas exchange. Results: The relative peak oxygen uptake (V̇O2peak) value during swimming was 49.3 ± 6.2 mL/kg/min, which was higher than that during arm cranking (39.6 ± 7.3 mL/kg/min; P < 0.01) but lower than that during cycling (54.3 ± 7.8 mL/kg/min; P < 0.01). The peak minute ventilation (V̇Epeak) value during swimming (84.9 ± 12.6 L/min) was higher than that during arm cranking (69.4 ± 18.2 L/min; P < 0.01) but lower than that during cycling (98.4 ± 15.4 L/min; P < 0.01). Strong positive correlations were observed in the absolute and relative V̇O2peak values between swimming and cycling (r = 0.857, P < 0.01; r = 0.657, P < 0.05) and between swimming and arm cranking (r = 0.899, P < 0.01; r = 0.863, P < 0.05). A strong positive correlation was also observed in V̇Epeak values between swimming and arm cranking (r = 0.626, P < 0.05). Conclusion: Swimmers aged 11–13 years showed V̇O2peak and V̇Epeak values during the specific swimming test greater than those during arm cranking but lower than those during cycling. However, aerobic capacity parameters measured during specific swimming conditions correlated with those measured during non–specific arm cranking and cycling conditions. [ABSTRACT FROM AUTHOR]