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2. Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region

Author

Grillet, Maria E, Hernández-Villena, Juan V, Llewellyn, Martin S, Paniz-Mondolfi, Alberto E, Tami, Adriana, Vincenti-Gonzalez, Maria F, Marquez, Marilianna, Mogollon-Mendoza, Adriana C, Hernandez-Pereira, Carlos E, Plaza-Morr, Juan D, Blohm, Gabriella, Grijalva, Mario J, Costales, Jaime A, Ferguson, Heather M, Schwabl, Philipp, Hernandez-Castro, Luis E, Lamberton, Poppy H L, Streicker, Daniel G, Haydon, Daniel T, Miles, Michael A, Acosta-Serrano, Alvaro, Acquattela, Harry, Basañez, Maria G, Benaim, Gustavo, Colmenares, Luis A, Conn, Jan E, Espinoza, Raul, Freilij, Hector, Graterol-Gil, Mary C, Hotez, Peter J, Kato, Hirotomo, Lednicky, John A, Martinez, Clara E, Mas-Coma, Santiago, Morris, J Glen, Jr, Navarro, Juan C, Ramirez, Jose L, Rodriguez, Marlenes, Urbina, Julio A, Villegas, Leopoldo, Segovia, Maikell J, Carrasco, Hernan J, Crainey, James L, Luz, Sergio L B, Moreno, Juan D, Noya Gonzalez, Oscar O, Ramírez, Juan D, and Alarcón-de Noya, Belkisyolé

Published
2019
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5. The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector

Author

Casas-Sanchez, Aitor, primary, Ramaswamy, Raghavendran, additional, Perally, Samïrah, additional, Haines, Lee R., additional, Rose, Clair, additional, Aguilera-Flores, Marcela, additional, Portillo, Susana, additional, Verbeelen, Margot, additional, Hussain, Shahid, additional, Smithson, Laura, additional, Yunta, Cristina, additional, Lehane, Michael J., additional, Vaughan, Sue, additional, van den Abbeele, Jan, additional, Almeida, Igor C., additional, Boulanger, Martin J., additional, and Acosta-Serrano, Álvaro, additional

Published
2023
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9. Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

Author

Al-Salem, Waleed S., Solórzano, Carla, Weedall, Gareth D., Dyer, Naomi A., Kelly-Hope, Louise, Casas-Sánchez, Aitor, Alraey, Yasser, Alyamani, Essam J., Halliday, Alice, Balghonaim, Salah M., Alsohibany, Khalid S., Alzeyadi, Zeyad, Alzahrani, Mohamed H., Al-Shahrani, Ali M., Assiri, Abdullah M., Memish, Ziad, and Acosta-Serrano, Álvaro

Published
2019
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12. Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection

Author

Casas-Sanchez, Aitor, primary, Romero-Ramirez, Alessandra, additional, Hargreaves, Eleanor, additional, Ellis, Cameron C., additional, Grajeda, Brian I., additional, Estevao, Igor L., additional, Patterson, Edward I., additional, Hughes, Grant L., additional, Almeida, Igor C., additional, Zech, Tobias, additional, and Acosta-Serrano, Álvaro, additional

Published
2022
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15. Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific forLeishmania majorInfection

Author

Montoya, Alba L., primary, Austin, Victoria M., additional, Portillo, Susana, additional, Vinales, Irodiel, additional, Ashmus, Roger A., additional, Estevao, Igor, additional, Jankuru, Sohan R., additional, Alraey, Yasser, additional, Al-Salem, Waleed S., additional, Acosta-Serrano, Álvaro, additional, Almeida, Igor C., additional, and Michael, Katja, additional

Published
2021
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18. Protein N-glycosylation is essential for SARS-CoV-2 infection

Author

Casas-Sanchez, Aitor, primary, Romero-Ramirez, Alessandra, additional, Hargreaves, Eleanor, additional, Ellis, Cameron C., additional, Grajeda, Brian I., additional, Estevao, Igor, additional, Patterson, Edward I., additional, Hughes, Grant L., additional, Almeida, Igor C., additional, Zech, Tobias, additional, and Acosta-Serrano, Álvaro, additional

Published
2021
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19. Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

Author

Kozak, Radoslaw P., primary, Mondragon-Shem, Karina, additional, Williams, Christopher, additional, Rose, Clair, additional, Perally, Samirah, additional, Caljon, Guy, additional, Van Den Abbeele, Jan, additional, Wongtrakul-Kish, Katherine, additional, Gardner, Richard A., additional, Spencer, Daniel, additional, Lehane, Michael J., additional, and Acosta-Serrano, Álvaro, additional

Published
2021
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20. Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Author

Sterkel, Marcos, primary, Haines, Lee R., additional, Casas-Sánchez, Aitor, additional, Owino Adung’a, Vincent, additional, Vionette-Amaral, Raquel J., additional, Quek, Shannon, additional, Rose, Clair, additional, Silva dos Santos, Mariana, additional, García Escude, Natalia, additional, Ismail, Hanafy M., additional, Paine, Mark I., additional, Barribeau, Seth M., additional, Wagstaff, Simon, additional, MacRae, James I., additional, Masiga, Daniel, additional, Yakob, Laith, additional, Oliveira, Pedro L., additional, and Acosta-Serrano, Álvaro, additional

Published
2021
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21. Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays

Author

Patterson, Edward I, primary, Prince, Tessa, additional, Anderson, Enyia R, additional, Casas-Sanchez, Aitor, additional, Smith, Shirley L, additional, Cansado-Utrilla, Cintia, additional, Solomon, Tom, additional, Griffiths, Michael J, additional, Acosta-Serrano, Álvaro, additional, Turtle, Lance, additional, and Hughes, Grant L, additional

Published
2020
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22. Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Author

Sterkel, Marcos, primary, Haines, Lee R., additional, Casas-Sánchez, Aitor, additional, Adung’a, Vincent Owino, additional, Vionette-Amaral, Raquel J., additional, Quek, Shannon, additional, Rose, Clair, additional, dos Santos, Mariana Silva, additional, Escude, Natalia Garcia, additional, Ismael, Hanafy, additional, Paine, Mark I., additional, Barribeau, Seth M., additional, Wagstaff, Simon, additional, MacRae, James I., additional, Masiga, Daniel, additional, Yakob, Laith, additional, Oliveira, Pedro L., additional, and Acosta-Serrano, Álvaro, additional

Published
2020
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25. Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates

Author

Bailey, Freddie, primary, Mondragon-Shem, Karina, additional, Haines, Lee Rafuse, additional, Olabi, Amina, additional, Alorfi, Ahmed, additional, Ruiz-Postigo, José Antonio, additional, Alvar, Jorge, additional, Hotez, Peter, additional, Adams, Emily R., additional, Vélez, Iván D., additional, Al-Salem, Waleed, additional, Eaton, Julian, additional, Acosta-Serrano, Álvaro, additional, and Molyneux, David H., additional

Published
2019
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27. Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Leishmania majorInfection

Author

Montoya, Alba L., Austin, Victoria M., Portillo, Susana, Vinales, Irodiel, Ashmus, Roger A., Estevao, Igor, Jankuru, Sohan R., Alraey, Yasser, Al-Salem, Waleed S., Acosta-Serrano, Álvaro, Almeida, Igor C., and Michael, Katja

Abstract

All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important roles in immunoglycomics: (a) potential protection against certain parasitic and viral zoonotic infections; (b) targeting of α-Gal-engineered cancer cells; (c) aiding in tissue repair; and (d) serving as adjuvants in α-Gal-based vaccines. Patients with certain protozoan infections have specific anti-α-Gal antibodies, elicited against parasite-derived α-Gal-bearing glycotopes. These glycotopes, however, remain elusive except for the well-characterized glycotope Galα1,3Galβ1,4GlcNAcα, expressed by Trypanosoma cruzi. The discovery of new parasitic glycotopes is greatly hindered by the enormous structural diversity of cell-surface glycans and the technical challenges of classical immunoglycomics, a top-down approach from cultivated parasites to isolated glycans. Here, we demonstrate that reversed immunoglycomics, a bottom-up approach, can identify parasite species-specific α-Gal-bearing glycotopes by probing synthetic oligosaccharides on neoglycoproteins. This method was tested here seeking to identify as-yet unknown glycotopes specific for Leishmania major, the causative agent of Old-World cutaneous leishmaniasis (OWCL). Neoglycoproteins decorated with synthetic α-Gal-containing oligosaccharides derived from L. majorglycoinositolphospholipids served as antigens in a chemiluminescent enzyme-linked immunosorbent assay using sera from OWCL patients and noninfected individuals. Receiver-operating characteristic analysis identified Galpα1,3Galfβ and Galpα1,3Galfβ1,3Manpα glycotopes as diagnostic biomarkers for L. major-caused OWCL, which can distinguish with 100% specificity from heterologous diseases and L. tropica-caused OWCL. These glycotopes could prove useful in the development of rapid α-Gal-based diagnostics and vaccines for OWCL. Furthermore, this method could help unravel cryptic α-Gal-glycotopes of other protozoan parasites and enterobacteria that elicit the natural human anti-α-Gal antibodies.

Published
2021
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29. Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs

Author

Silva Pereira, Sara, primary, Casas-Sánchez, Aitor, additional, Haines, Lee R., additional, Ogugo, Moses, additional, Absolomon, Kihara, additional, Sanders, Mandy, additional, Kemp, Steve, additional, Acosta-Serrano, Álvaro, additional, Noyes, Harry, additional, Berriman, Matthew, additional, and Jackson, Andrew P., additional

Published
2018
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31. Skin deep

Author

Casas-Sánchez, Aitor, primary and Acosta-Serrano, Álvaro, additional

Published
2016
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32. MOESM2 of Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

Author

Al-Salem, Waleed, Solórzano, Carla, Weedall, Gareth, Dyer, Naomi, Kelly-Hope, Louise, Casas-Sánchez, Aitor, Alraey, Yasser, Alyamani, Essam, Halliday, Alice, Balghonaim, Salah, Alsohibany, Khalid, Alzeyadi, Zeyad, Alzahrani, Mohamed, Al-Shahrani, Ali, Assiri, Abdullah, Memish, Ziad, and Acosta-Serrano, Álvaro

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 2: Figure S1. Scheme representing the current leishmaniasis treatment policy in KSA. Figure S2. Leishmania spp. identification in Central Region by PCR-RFLP analysis of parasite ITS1 region. Lane Lt: L. tropica positive control; Lane Lm: L. major positive control; Lanes 1–10: different examples of Leishmania isolates from Rass, Dwadmi and Muzahmyyah. Figure S3. Leishmania spp identification in Al Madinah Province by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–4: different examples of Leishmania isolates from Aljadaida and Sulailah, Al Madinah Province; Lanes 1 and 2: L. tropica samples; Lanes 3 and 4: L. major samples; Lane Lm: L. major positive control; Lane Lt: L. tropica positive control. Figure S4. Leishmania spp. identification in Al Ahsa Region by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–13: different examples of Leishmania isolates from Al Ahsa Region; Lane Lt: L. tropica positive control; Lane Lm: L. major positive control. Figure S5. Leishmania spp identification in Asir Region by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–5: different examples of Leishmania isolates from Asir Province. Figure S6. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the Eastern region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA). Figure S7. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the Northwest region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA). Figure S8. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the southwest region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA).

33. MOESM2 of Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

Author

Al-Salem, Waleed, Solórzano, Carla, Weedall, Gareth, Dyer, Naomi, Kelly-Hope, Louise, Casas-Sánchez, Aitor, Alraey, Yasser, Alyamani, Essam, Halliday, Alice, Balghonaim, Salah, Alsohibany, Khalid, Alzeyadi, Zeyad, Alzahrani, Mohamed, Al-Shahrani, Ali, Assiri, Abdullah, Memish, Ziad, and Acosta-Serrano, Álvaro

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 2: Figure S1. Scheme representing the current leishmaniasis treatment policy in KSA. Figure S2. Leishmania spp. identification in Central Region by PCR-RFLP analysis of parasite ITS1 region. Lane Lt: L. tropica positive control; Lane Lm: L. major positive control; Lanes 1–10: different examples of Leishmania isolates from Rass, Dwadmi and Muzahmyyah. Figure S3. Leishmania spp identification in Al Madinah Province by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–4: different examples of Leishmania isolates from Aljadaida and Sulailah, Al Madinah Province; Lanes 1 and 2: L. tropica samples; Lanes 3 and 4: L. major samples; Lane Lm: L. major positive control; Lane Lt: L. tropica positive control. Figure S4. Leishmania spp. identification in Al Ahsa Region by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–13: different examples of Leishmania isolates from Al Ahsa Region; Lane Lt: L. tropica positive control; Lane Lm: L. major positive control. Figure S5. Leishmania spp identification in Asir Region by PCR-RFLP analysis of parasite ITS1 region. Lanes 1–5: different examples of Leishmania isolates from Asir Province. Figure S6. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the Eastern region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA). Figure S7. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the Northwest region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA). Figure S8. Distribution of Leishmania species (a) and patient response to anti-leishmanial treatment (b) within the southwest region of Saudi Arabia. The map was created using software ArcGIS 10 (ESRI, Redlands, CA).

36. Tsetse flies ( Glossina morsitans morsitans ) choose birthing sites guided by substrate cues with no evidence for a role of pheromones.

Author

Adden AK, Haines LR, Acosta-Serrano Á, and Prieto-Godino LL

Subjects
Animals, Female, Pregnancy, Pheromones, Cues, Parturition, Larva, Tsetse Flies
Abstract

Tsetse flies significantly impact public health and economic development in sub-Saharan African countries by transmitting the fatal disease African trypanosomiasis. Unusually, instead of laying eggs, tsetse birth a single larva that immediately burrows into the soil to pupate. Where the female chooses to larviposit is, therefore, crucial for offspring survival. Previous laboratory studies suggested that a putative larval pheromone, n -pentadecane, attracts gravid female Glossina morsitans morsitans to appropriate larviposition sites. However, this attraction could not be reproduced in field experiments. Here, we resolve this disparity by designing naturalistic laboratory experiments that closely mimic the physical characteristics found in the wild. We show that gravid G. m. morsitans were neither attracted to the putative pheromone nor, interestingly, to pupae placed in the soil. By contrast, females appear to choose larviposition sites based on environmental substrate cues. We conclude that, among the many cues that likely contribute to larviposition choice in nature, substrate features are a main determinant, while we failed to find evidence for a role of pheromones.

Published
2023
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37. Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection.

Author

Casas-Sanchez A, Romero-Ramirez A, Hargreaves E, Ellis CC, Grajeda BI, Estevao IL, Patterson EI, Hughes GL, Almeida IC, Zech T, and Acosta-Serrano Á

Subjects
Humans, Glycosylation, Polysaccharides metabolism, COVID-19 metabolism, COVID-19 prevention & control, SARS-CoV-2 genetics, Spike Glycoprotein, Coronavirus metabolism
Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively N- glycosylates its spike proteins, which are necessary for host cell invasion and the target of both vaccines and immunotherapies. These N- glycans are predicted to modulate spike binding to the host receptor by stabilizing its open conformation and host immunity evasion. Here, we investigated the essentiality of both the host N -glycosylation pathway and SARS-CoV-2 N- glycans for infection. Ablation of host N- glycosylation using RNA interference or inhibitors, including FDA-approved drugs, reduced the spread of the infection, including that of variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta). Under these conditions, cells produced fewer virions and some completely lost their infectivity. Furthermore, partial enzymatic deglycosylation of intact virions showed that surface-exposed N- glycans are critical for cell invasion. Altogether, we propose protein N- glycosylation as a targetable pathway with clinical potential for treatment of COVID-19. IMPORTANCE The coronavirus SARS-CoV-2 uses its spike surface proteins to infect human cells. Spike proteins are heavily modified with several N -glycans, which are predicted to modulate their function. In this work, we show that interfering with either the synthesis or attachment of spike N -glycans significantly reduces the spread of SARS-CoV-2 infection in vitro , including that of several variants. As new SARS-CoV-2 variants, with various degrees of resistance against current vaccines, are likely to continue appearing, halting virus glycosylation using repurposed human drugs could result in a complementary strategy to reducing the spread of COVID-19 worldwide.

Published
2021
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