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Researchers from the University of New South Wales conducted a study on the pathogenic mechanisms of Aeromonas veronii and Escherichia coli in human macrophages. The study found that A. veronii induced higher levels of inflammation and apoptosis in macrophages compared to E. coli. A. veronii also downregulated the expression of histone genes, suggesting a unique impact on host cell gene expression. This research provides new insights into the pathogenic mechanisms of A. veronii as a human enteric pathogen. [Extracted from the article]

A study conducted at Auburn University focused on high-efficiency genome editing in naturally isolated strains of Aeromonas hydrophila and Edwardsiella piscicida using the CRISPR-Cas9 system. These bacteria are significant pathogens in aquaculture and can also cause infections in humans. The research aimed to develop tools for understanding pathogenic mechanisms and developing targeted strategies for control. The study successfully generated deletion mutants and insertion mutants in these pathogens, providing valuable tools for studying bacterial pathogenesis and developing effective control strategies. [Extracted from the article]

The article investigates carbapenemase-encoding genes in Burkholderia cepacia and Aeromonas sobria nosocomial infections among Iraqi patients. The study conducted in Ramadi Teaching Hospitals in 2024 found high antimicrobial resistance in isolates of B. cepacia and A. sobria, with a notable prevalence of blaKPC and blaGES carbapenemase producers. The research concluded that recA gene identification was a sensitive and specific technique for detecting B. cepacia complex isolates, and no isolates tested positive for the blaIMP gene. [Extracted from the article]

Researchers at the University of Guilan in Iran have developed a new in-silico approach to design a multiepitope peptide as a potential vaccine candidate for Aeromonas hydrophila, a Gram-negative bacterium commonly found in aquatic environments. The study aimed to address the challenges posed by antibiotic resistance in combating A. hydrophila infections by creating a vaccine candidate with high immunogenicity and safety profiles. The designed vaccine, consisting of 15 epitopes for B and T cells, showed promising results in virtual tests, indicating its potential effectiveness in combating A. hydrophila infections. Further research is needed to validate the safety, efficacy, and long-term impacts of this vaccine candidate. [Extracted from the article]

Research from Jilin Agricultural University in Changchun, People's Republic of China, focused on developing a phage lysate vaccine to combat infections caused by the Gram-Negative Bacteria Aeromonas hydrophila in crucian carp. The study optimized phage lysis conditions and compared immune responses of fish receiving the phage lysate vaccine to those receiving formaldehyde-inactivated vaccines. Results showed enhanced immunity in fish receiving the phage lysate vaccine, with a high protection rate of 88.89% in challenge tests post-immunization. This research contributes to the development of phage-based aquatic vaccines and was peer-reviewed. [Extracted from the article]

Researchers from Federation University Australia have highlighted the importance of monitoring the spread of resistance to polymyxin antibiotics, particularly through the mobilized colistin resistance gene mcr-3 found in the Aeromonas genus. This gene has been shown to increase resistance in naive E. coli and Aeromonas spp., posing a significant risk for the dissemination of resistance to polymyxins. The study delves into the genetic background of the mcr gene, the epidemiology of mcr-positive isolates, and the relationship between intrinsic and transferable mcr resistance genes, with a focus on mcr-3 and related genes. [Extracted from the article]

A recent study conducted at Changshu No. 2 People's Hospital in Suzhou, China, reported a case of severe pneumonia caused by Aeromonas dhakensis infection in a 56-year-old male with a severe atrial septal defect. The patient presented with severe hypoxemia and septic shock, and metagenomic next generation sequencing confirmed the Aeromonas dhakensis infection in the bronchoalveolar lavage fluid and peripheral blood. This research sheds light on the increasing recognition of Aeromonas dhakensis as a human pathogen, with more cases being reported in recent years. [Extracted from the article]

The article discusses the potential use of cyclic dipeptides derived from Aeromonas veronii V03 as antivirulence agents against Candida albicans infection. These dipeptides showed antibacterial activity against various pathogens and inhibited the virulence traits of C. albicans, such as yeast-to-hyphae transition, hydrolase secretion, and biofilm formation. The study suggests that these cyclic dipeptides could be developed into novel antifungal drugs to combat C. albicans infections. [Extracted from the article]

Researchers from the Indian Institute of Science Education and Research Kolkata conducted a study on pathogenic bacteria isolated from diseased Labeo rohita fish in West Bengal, India. The study focused on identifying and characterizing the virulence genes of bacterial strains, with Aeromonas hydrophila and Pseudomonas aeruginosa being highlighted for their pathogenicity. The research emphasized the importance of understanding aquatic microbial pathogens to manage and prevent fish diseases in aquaculture. For more information, the full article can be accessed in AIMS Molecular Science. [Extracted from the article]

A recent study conducted at University Hospital Marques Valdecilla in Santander, Spain, focused on analyzing the virulence genes of Aeromonas species isolated from feces. The research aimed to compare the distribution of these genes between different species of Aeromonas and determine their presence in enterotoxigenic strains versus co-pathogen strains. The study found no significant differences in the distribution of virulence genes based on the co-existence of co-pathogens. A. hydrophila was identified as the potentially most virulent species among the strains studied. [Extracted from the article]

A study conducted at Hasanuddin University in Makassar, Indonesia, evaluated the use of CpG-ODN as an immunostimulant and protective agent against Aeromonas hydrophila in freshwater lobsters. The research found that CpG-ODN 2006 showed significant immunostimulant effects, while CpG-ODN 2133 exhibited potential as a protecting agent against the bacteria. These findings contribute to understanding immunostimulant strategies and protective mechanisms in freshwater lobsters, with potential implications for disease management in aquaculture. The study was published in the Bulletin of the European Association of Fish Pathologists and can be accessed online. [Extracted from the article]

Researchers from Southwest University in Chongqing, China have conducted a study on attenuated vaccines for Aeromonas veronii, an opportunistic pathogen that poses a threat to aquaculture and human health. The researchers constructed single and double gene deletion strains of A. veronii and found that the mutant strains had lower toxicity and decreased pathogenicity compared to the wild-type strain. They also evaluated the efficacy of one of the mutant strains as a live attenuated vaccine and found that it provided improved protection compared to an inactivated vaccine. These findings contribute to our understanding of A. veronii pathogenicity and provide a potential candidate for a live attenuated vaccine. [Extracted from the article]

A study conducted by researchers from the University of Barcelona and the Marine and Coastal Research Institute in Colombia has found potentially pathogenic bacteria in microplastics extracted from the Cienaga Grande de Santa Marta, the largest coastal lagoon system in the Colombian Caribbean. These bacteria form biofilms on the surface of microplastics, creating ecosystems known as plastispheres that are resistant to environmental changes. The presence of microplastics in fish consumed by the local population poses a risk to both the natural ecosystem and human health. The study highlights the need for integrated environmental management and public health strategies to address this issue. [Extracted from the article]

Researchers at Bohai University in Liaoning, China have conducted a study on the inhibitory effect of peptide SF on dual-species biofilms of Vibrio parahaemolyticus and Aeromonas sobria. The study found that peptide SF significantly inhibited the activity of the autoinducer-2 (AI-2)/LuxS quorum sensing system, as well as the production of extracellular polysaccharides, proteins, DNA, metabolic activity, hydrophobicity, and auto-aggregation of the biofilms. Peptide SF also down-regulated the expression of key genes related to quorum sensing, flagellum, virulence factors, and extracellular polymeric substances in the dual-species biofilms. This research provides a potential quorum sensing inhibitor for controlling multi-species biofilms caused by V. parahaemolyticus. [Extracted from the article]

A recent study conducted by researchers at Ehime University in Japan explored the susceptibility of common carp to a new ulcer disease caused by atypical Aeromonas salmonicida. The study found that the susceptibility of carp to the disease was not dependent on body size, but rather on temperature. Carp between 4-7 cm in length and weighing 1.6-8.6 g exhibited similar susceptibility. The research also noted that A. salmonicida cultured at 25 degrees C had reduced virulence compared to the bacterium cultured at 20 degrees C. The study concluded that a higher disease occurrence rate was observed at a water temperature of 25 degrees C during infection, with faster symptom recovery. [Extracted from the article]

A study conducted by researchers at the University of Niigata in Japan explores the carbon storage regulator (Csr) system in Aeromonas salmonicida, a Gram-negative bacterium. The study found that the Csr system in A. salmonicida affects various phenotypes, including glycogen biosynthesis, biofilm formation, motility, and stability of small RNA molecules. The research highlights the conservation and functionality of the Csr system in A. salmonicida and raises questions about its regulatory targets and mechanisms. The study was supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. [Extracted from the article]

A new report from Liaquat National Hospital and Medical College in Karachi, Pakistan, discusses a case of necrotizing fasciitis (NF) caused by Aeromonas Hydrophila (AH) following laparoscopic surgery. The patient, a 72-year-old female with a history of hypertension, developed NF in the lower abdomen after laparoscopic cholecystectomy. Despite extensive surgical debridement and antibiotic treatment, the patient died from septic complications. This case highlights the need for further analysis of the behavior of such microbes in high-risk patients through collective case studies. This research has been peer-reviewed and published in the Journal of the Pakistan Medical Association. [Extracted from the article]

Researchers at the Chinese Academy of Agricultural Sciences have conducted a study on the use of an oral vaccine to prevent the spread of Aeromonas veronii in aquaculture. The study used a mutant form of the virulence factor aerolysin as a target antigen. The results showed that the vaccine effectively activated the immune response in zebrafish, increasing the expression of immune-related genes and antibodies. Additionally, the vaccine altered the structure of the gut microbiota. The study concludes that the vaccine could be an effective method for preventing A. veronii infection in fish aquaculture. [Extracted from the article]

A recent study conducted by researchers from Shandong University in China has investigated the molecular immune mechanism of macrophage response to Aeromonas veronii infection. Macrophages are innate immunity cells that play a crucial role in infectious immunity. The study found that macrophages infected with A. veronii released large amounts of cytokines and triggered NLRP3-dependent pyroptosis. Through integrated analysis of miRNA-mRNA, the study identified several pathways involved in macrophage response to A. veronii infection. The findings provide potential therapeutic targets for the prevention and treatment of A. veronii infectious diseases. [Extracted from the article]

A study conducted by researchers at Hunan Normal University in China has found that wogonin, an active ingredient in Scutellariae Radix (SR), has anti-inflammatory and antioxidant effects on fish infected with Aeromonas hydrophila. The researchers screened 32 active ingredients of SR and identified 124 target genes associated with anti-inflammatory effects. They found that wogonin-AKT2 was the key regulated module in the active ingredient-hub protein-key pathway network. The study suggests that wogonin could be used as a means of treating fish diseases and provides a theoretical basis for the prevention of such diseases. [Extracted from the article]

Researchers from the Chinese Academy of Fishery Sciences have conducted a study on Aeromonas hydrophila, a bacterium that causes disease in frogs. The study found that two dominant bacteria, Aeromonas hydrophila Rd001 and Acinetobacter johnsonii Rd002, were isolated from naturally infected frogs. Experimental infection confirmed that Rd001 was the primary pathogen responsible for the disease. The study also identified the virulence genotype and antimicrobial susceptibility of Rd001, as well as its genetic traits. This research provides valuable information for preventing and controlling A. hydrophila infections in frogs. [Extracted from the article]

A research report from Jeonbuk National University in South Korea discusses the findings on Aeromonas, a type of Gram-Negative Bacteria. The study focuses on the transmission of antibiotic resistance genes (ARGs) in freshwater environments, particularly in relation to Aeromonas spp. The researchers conducted whole-genome sequencing on five environmental strains of Aeromonas spp. and identified conserved intrinsic resistance determinants called Aeromonas Qnr (AQnr) proteins. The study emphasizes the importance of understanding and monitoring these AQnr families to prevent the clinical emergence of antibiotic resistance. The research has been peer-reviewed and published in the Journal of Microbiology and Biotechnology. [Extracted from the article]

Researchers from the First Affiliated Hospital of Chongqing Medical University in China have reported a rare case of fulminant fatal pneumonia and bacteremia caused by Aeromonas dhakensis in an immunocompetent man. The patient, a 26-year-old man, developed pneumonia after swimming in a river and died shortly after admission to the hospital. A. dhakensis was isolated from blood culture and bronchoalveolar lavage fluid, and was also detected in lung tissue using metagenomic next-generation sequencing. The researchers suggest that A. dhakensis should be considered in cases of fulminant pneumonia after exposure to aquatic environments, and that metagenomic next-generation sequencing may be a more sensitive and specific method for detecting aquatic pathogens compared to traditional bacterial culture. [Extracted from the article]

A rare case report and review of the literature from the Medical College of Nanchang University in China discusses the first case of super-refractory status epilepticus (SRSE) in a woman with Aeromonas caviae meningitis. The research highlights the lack of knowledge regarding this condition and emphasizes the importance of effective treatment for epilepsy in improving patient prognosis. The study suggests that a combination of one anesthetic drug and three non-anesthetic anti-epileptic drugs may be helpful in managing SRSE caused by Aeromonas caviae meningitis. This information is valuable for researchers and medical professionals studying and treating epilepsy and central nervous system infections. [Extracted from the article]

A study conducted by the University of Texas Medical Branch provides new insights into Aeromonas, a type of Gram-Negative Bacteria. The study analyzed 105 patients with Aeromonas infections and 112 isolates, examining their clinical presentations, outcomes, and antimicrobial resistance patterns. The research found that skin and soft tissue infections, traumatic wound infections, sepsis, burns, and intraabdominal infections were common. The study also identified high rates of antimicrobial resistance to carbapenems and piperacillin-tazobactam. The researchers concluded that tailored empirical therapy based on local antibiograms may lead to favorable outcomes. [Extracted from the article]

Researchers from the University of Stirling have published a new study on Aeromonas dhakensis, a bacterium that is increasingly recognized as an important pathogen in warm-water aquaculture and can also infect humans. The study highlights the need for accurate identification of A. dhakensis, as it may be more virulent than its close relative, Aeromonas hydrophila, and may pose zoonotic risks, including concerns for antibiotic-resistant strains. The researchers emphasize the importance of using reliable molecular tools for identification and call for further research to determine the true prevalence and impact of A. dhakensis in aquaculture, the environment, and healthcare settings. [Extracted from the article]

Researchers from the First Affiliated Hospital of Chongqing Medical University in China have published a case report on a 49-year-old female patient with multiple myeloma and renal failure who developed dysuria. The patient was found to have a urinary tract infection caused by multidrug-resistant Aeromonas caviae. After receiving treatment with piperacillin-tazobactam for seven days, her symptoms improved significantly. This case report aims to contribute to the diagnosis and management of Aeromonas caviae cystitis. [Extracted from the article]

A study conducted by Wenzhou Medical University in China examined the immune response of Procambarus clarkii (a type of crayfish) intestines to Aeromonas hydrophila bacterial infections. The researchers compared immune indexes, histopathological damage, and transcriptome data between infected and control crayfish. The results showed significant changes in intestinal tissue structure and enzyme activity, as well as differential gene expression related to cell processes and metabolic processes. The study provides important insights into the immune response of crayfish to A. hydrophila infection. [Extracted from the article]

Researchers at Emek Medical Center in Israel have conducted a study on Aeromonas species isolated from patients with gastroenteritis. The study aimed to investigate the antimicrobial susceptibility profiles of these isolates, explore the relationship between antimicrobial resistance (AMR) genes and resistance phenotypes, and describe the population structure of the isolates. The study found that A. caviae was the dominant species related to gastroenteritis and had a diverse population structure with limited evidence of common-source transmission. The resistance rates to most antimicrobial agents were low and partially correlated with the presence of resistance genes. [Extracted from the article]

A study conducted by the Qom University of Medical Sciences in Iran aimed to determine the prevalence of Aeromonas spp., Campylobacter spp., and Clostridioides difficile in immunocompromised children with diarrhea. The study analyzed stool samples from 130 patients and found that 14.6% were positive for Aeromonas spp., 9.2% for C. difficile, and 1.5% for C. jejuni. The researchers concluded that there is a need to increase hygiene levels and control bacterial diarrheal diseases, especially in areas with immunocompromised children. This study provides valuable insights into the presence of these pathogens in the region and their potential to cause gastroenteritis in vulnerable populations. [Extracted from the article]

A study conducted in Palampur, India, investigated the presence of Aeromonas spp. bacteria and their enterotoxins in ready-to-eat (RTE) food products and drinking water samples. The study found that 7.3% of the samples were contaminated with Aeromonas spp., with higher contamination rates in RTE milk products. The isolates were identified as A. hydrophila, A. schubertii, A. sobria, and A. veronii. All isolates carried a cytotonic heat-labile enterotoxin, and some showed resistance to multiple drugs. The study suggests that Aeromonas spp. in RTE foods could pose a potential foodborne public health threat in the northwestern Himalayas. [Extracted from the article]

A recent study conducted at West China Second University Hospital in Chengdu, China, reported a rare case of multidrug-resistant Aeromonas caviae infection in a 4-year-old child with T-cell acute lymphoblastic leukemia. The infection affected the bloodstream and intestine of the patient. The researchers used blood and stool cultures to identify the infection and treated the patient with linezolid, levofloxacin, and polymyxin B. The study highlights the importance of early recognition and effective treatment in improving prognosis and reducing mortality. The researchers also reviewed the literature on Aeromonas infection in pediatric leukemia and found an increasing trend of drug-resistant strains. [Extracted from the article]

A recent study conducted by researchers at Qingdao Agricultural University in China has focused on Vibrio vulnificus, a pathogen that causes skin ulcers and hemorrhagic septicemia in fish, leading to high mortality rates in aquaculture. The researchers developed a bivalent inactivated vaccine against both Vibrio vulnificus and Aeromonas salmonicida, another pathogen responsible for furunculosis in fish. The vaccine was found to be immunogenic and effectively prevented infection in turbot, a type of fish commonly affected by these diseases. The study suggests that this vaccine has potential applications in aquaculture. [Extracted from the article]

A new report discusses research findings on Yersinia enterocolitica, a bacterium that causes various human diseases, including gastroenteritis. The study focused on the immune response and antimicrobial susceptibility of macrophages infected with a strain of Aeromonas caviae and Yersinia enterocolitica recovered from the same fecal sample of a patient with diarrhea. The results showed that mixed infections caused more cell damage and overexpression of immune-related genes compared to single infections. Additionally, the study found an increase in antimicrobial resistance for certain antibiotics after infection with mixed cultures. This research provides insight into the impact of mixed infections on treatment and infection evolution. [Extracted from the article]

A study conducted by the University of California Los Angeles (UCLA) has found that plumbing issues and heat waves may be associated with nosocomial infections caused by carbapenemase-producing Aeromonas hydrophila. The research involved investigating a cluster of infections in two intensive care units, where patients with underlying comorbidities were infected with extensively drug-resistant (XDR) Aeromonas. The study identified diverse carbapenemase genes in the bacteria, highlighting the need for increased infection prevention measures during periods of plumbing problems, particularly in conjunction with heat waves. The research was published in the American Journal of Infection Control. [Extracted from the article]

Researchers from Fuyang Normal University in China have identified potential polyvalent passive vaccine candidates for Aeromonas hydrophila, a Gram-negative bacteria that affects fish. The study focused on the antibodies of outer membrane proteins (OMPs) of the bacteria, which can be obtained from egg yolk and have the potential to be used in aquaculture. The researchers found that certain IgY antibodies had an effective immune protection rate, activated innate immune responses, reduced inflammation and antioxidant reactions, protected tissue structure, and reduced apoptosis and DNA damage in infected kidney cells. The study suggests that IgY antibodies of specific OMPs can be considered as potential vaccine candidates for passive immunization in aquaculture. [Extracted from the article]

Researchers from the University of Putra Malaysia have conducted a study on the potential use of probiotics isolated from Pangasius nasutus, a type of fish, to combat infections caused by Aeromonas hydrophila and Streptococcus agalactiae. The study found that five probiotic strains inhibited the growth of A. hydrophila, with two strains also inhibiting the growth of S. agalactiae. The potential bacterial strains were identified as Lactococcus lactis, Weissella confusa, Cosenzaea myxofaciens, Lactococcus garvieae, and Plesiomonas shigelloides. Further research is needed to fully understand the mechanisms and potential of these strains as probiotics. The study was supported by a research grant from the Ministry of Education, Malaysia. [Extracted from the article]

A new study conducted by researchers at University Hospital Geneva explores the microbiological features of drowning-associated pneumonia (DAP). The study aimed to determine the prevalence of DAP, the microorganisms involved, and the impact of DAP on drowned patients. The researchers conducted a systematic review and meta-analysis of studies published between 2000 and 2023, involving 688 patients. They found that DAP is commonly caused by Gram-negative bacteria, particularly Aeromonas sp., which is exclusively isolated following freshwater drowning. The study suggests that empirical antimicrobial therapy should consider covering these bacteria, as amoxicillin-clavulanate may be inadequate in about one-third of cases. However, the impact of DAP on patients' outcomes remains unclear. [Extracted from the article]

Researchers at Zhengzhou University People's Hospital in China have published a case report and literature review on pulmonary infection with Aeromonas dhakensis in a patient with acute T lymphoblastic leukemia. Aeromonas dhakensis is a relatively rare gram-negative bacterium that has been associated with strong virulence and poor prognosis. The patient in the case study experienced myelosuppression after chemotherapy and developed a secondary pulmonary infection with Aeromonas dhakensis. The researchers emphasize the importance of early and accurate diagnosis through pathogenic sequencing in order to provide effective anti-infection treatment. [Extracted from the article]

A research study conducted in Chongqing, China, has found that Aeromonas dhakensis, a type of bacteria, can cause severe infections in humans. The study reports on the case of a 26-year-old man who initially presented with community-acquired pneumonia but rapidly developed multiple organ failure and died. The study highlights the importance of considering unusual pathogens in cases of pneumonia with severe symptoms and emphasizes the need for timely diagnosis and treatment. The researchers recommend that doctors be vigilant in identifying the difference between infections caused by different microorganisms and suggest the use of empirical drugs for respiratory symptoms. [Extracted from the article]