1. Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals
- Author
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Premeaux, Thomas A, D’Antoni, Michelle L, Abdel-Mohsen, Mohamed, Pillai, Satish K, Kallianpur, Kalpana J, Nakamoto, Beau K, Agsalda-Garcia, Melissa, Shiramizu, Bruce, Shikuma, Cecilia M, Gisslén, Magnus, Price, Richard W, Valcour, Victor, and Ndhlovu, Lishomwa C
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Pediatric AIDS ,Neurosciences ,Aging ,Pediatric ,HIV/AIDS ,Clinical Research ,Brain Disorders ,Infectious Diseases ,Acquired Cognitive Impairment ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Infection ,Adult ,Age Factors ,Anti-HIV Agents ,Antigens ,CD ,Antigens ,Differentiation ,Myelomonocytic ,Antiretroviral Therapy ,Highly Active ,Biomarkers ,Case-Control Studies ,Central Nervous System ,Cognition ,Female ,Galectins ,HIV Infections ,HIV-1 ,Humans ,Male ,Middle Aged ,Neopterin ,Neuropsychological Tests ,RNA ,Viral ,Receptors ,Cell Surface ,Viremia ,Galectin-9 ,HIV ,Neuroinflammation ,Cognitive disorders ,Clinical Sciences ,Virology ,Clinical sciences ,Medical microbiology - Abstract
We previously reported that galectin-9 (Gal-9), a soluble lectin with immunomodulatory properties, is elevated in plasma during HIV infection and induces HIV transcription. The link between Gal-9 and compromised neuronal function is becoming increasingly evident; however, the association with neuroHIV remains unknown. We measured Gal-9 levels by ELISA in cerebrospinal fluid (CSF) and plasma of 70 HIV-infected (HIV+) adults stratified by age (older > 40 years and younger
- Published
- 2019