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1. Interplay between the electrical transport properties of GeMn thin films and Ge substrates

Author

Sircar, N., Ahlers, S., Majer, C., Abstreiter, G., and Bougeard, D.

Subjects
Condensed Matter - Other Condensed Matter, Condensed Matter - Materials Science
Abstract

We present evidence that electrical transport studies of epitaxial p-type GeMn thin films fabricated on high resistivity Ge substrates are severely influenced by parallel conduction through the substrate, related to the large intrinsic conductivity of Ge due to its small bandgap. Anomalous Hall measurements and large magneto resistance effects are completely understood by taking a dominating substrate contribution as well as the measurement geometry into account. It is shown that substrate conduction persists also for well conducting, degenerate, p-type thin films, giving rise to an effective two-layer conduction scheme. Using n-type Ge substrates, parallel conduction through the substrate can be reduced for the p-type epi-layers, as a consequence of the emerging pn-interface junction. GeMn thin films fabricated on these substrates exhibit a negligible magneto resistance effect. Our study underlines the importance of a thorough characterization and understanding of possible substrate contributions for electrical transport studies of GeMn thin films., Comment: 9 pages, 9 figures

Published
2010
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2. Magnetic and structural properties of GeMn films: precipitation of intermetallic nanomagnets

Author

Ahlers, S., Bougeard, D., Sircar, N., Abstreiter, G., Trampert, A., Opel, M., and Gross, R.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Other Condensed Matter
Abstract

We present a comprehensive study relating the nanostructure of Ge_0.95Mn_0.05 films to their magnetic properties. The formation of ferromagnetic nanometer sized inclusions in a defect free Ge matrix fabricated by low temperature molecular beam epitaxy is observed down to substrate temperatures T_S as low as 70 deg. Celsius. A combined transmission electron microscopy (TEM) and electron energy-loss spectroscopy (EELS) analysis of the films identifies the inclusions as precipitates of the ferromagnetic compound Mn_5Ge_3. The volume and amount of these precipitates decreases with decreasing T_S. Magnetometry of the films containing precipitates reveals distinct temperature ranges: Between the characteristic ferromagnetic transition temperature of Mn_5Ge_3 at approximately room temperature and a lower, T_S dependent blocking temperature T_B the magnetic properties are dominated by superparamagnetism of the Mn_5Ge_3 precipitates. Below T_B, the magnetic signature of ferromagnetic precipitates with blocked magnetic moments is observed. At the lowest temperatures, the films show features characteristic for a metastable state., Comment: accepted for publication in Phys. Rev. B 74 (01.12.2006). High resolution images ibidem

Published
2006
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3. Clustering in a precipitate free GeMn magnetic semiconductor

Author

Bougeard, D., Ahlers, S., Trampert, A., Sircar, N., and Abstreiter, G.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Other Condensed Matter
Abstract

We present the first study relating structural parameters of precipitate free Ge0.95Mn0.05 films to magnetisation data. Nanometer sized clusters - areas with increased Mn content on substitutional lattice sites compared to the host matrix - are detected in transmission electron microscopy (TEM) analysis. The films show no overall spontaneous magnetisation at all down to 2K. The TEM and magnetisation results are interpreted in terms of an assembly of superparamagnetic moments developing in the dense distribution of clusters. Each cluster individually turns ferromagnetic below an ordering temperature which depends on its volume and Mn content., Comment: accepted for publication in Phys. Rev. Lett. (2006). High resolution images ibidem

Published
2006
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6. Early detection of pregnancy after IVF and embryo transfer with hyperglycosylated HCG versus Elecsys HCG+ß assay

Author

Bosch E, Hund M, van der Does R, Caracena L, Ahlers S, and Labarta E

Subjects
endocrine system, Pregnancy tests, urogenital system, In vitro fertilization, Human chorionic gonadotropin, Hyperglycosylated HCG, Assisted reproductive technologies, reproductive and urinary physiology, hormones, hormone substitutes, and hormone antagonists
Abstract

RESEARCH QUESTION: Is measurement of hyperglycosylated HCG (hHCG) superior to beta-HCG (HCG+ß) for early pregnancy detection after IVF and embryo transfer? DESIGN: Blood samples were collected on day 4 (+1), 7 (+1) and 11 (+2) after embryo transfer from women aged 18-45 years undergoing first or second fresh or frozen IVF embryo transfer cycles. Biochemical pregnancy was assessed on-site by HCG determination on day 11; clinical pregnancy was assessed by ultrasound on day 21 (+4/-3). Serum hHCG (immunochemiluminometric assay) and HCG+ß (Elecsys® HCG+ß assay) concentrations were measured. Performance of hHCG and HCG+ß for predicting pregnancy was evaluated and cut-offs selected. RESULTS: In total, 155 women were enrolled and underwent IVF and embryo transfer. Area under the curve (AUC) (95% CI) on day 4 was not significantly different for hHCG (AUC 0.88; 95% CI 0.83 to 0.94) and HCG+ß (AUC 0.90; 95% CI 0.84 to 0.95), as was predictive performance on day 7 and 11, with higher AUC estimates compared with day 4. Applying cut-offs derived according to Youden's index on day 4 (hHCG, 100 pg/ml; HCG+ß, 1.30 mIU/ml), both biomarkers demonstrated high negative predictive values for ruling out pregnancy (hHCG, 83.8%; HCG+ß, 82.8%) and high positive predictive values for ruling in pregnancy (hHCG, 89.0%; HCG+ß, 84.9%) on day 21. Diagnostic performance improved from day 4 to day 11. CONCLUSIONS: Predictive performance for early pregnancy post-IVF embryo transfer of day-5 blastocysts was not significantly different for hHCG and HCG+ß; hHCG superiority over HCG+ß was not shown.

Published
2022

9. Criteria of fault selection for geomechanical models

Author

Röckel, L., Ahlers, S., Morawietz, S., Reiter, K., Müller, B., and The SpannEnD Team

Subjects
Computer science, Fault (power engineering), Selection (genetic algorithm), Reliability engineering
Abstract

Numerical modelling is an important method in the improvement of the understanding of a variety of geological processes such as the reactivation of faults and seismicity, orogeny or volcanism. Furthermore, it can be crucial for geotechnical activities such as geothermal use of the underground, oil and gas production or the use of dams. Geomechanical models enable stress predictions even in areas without stress data and can therefore greatly contribute to the long-term safety and productivity of underground activities.As computational power is limited the geology of geomechanical models often needs to be simplified, especially for larger scale models. This is true not only for the resolution of the implemented stratigraphy but also for the implementation of faults as they severely increase the amount of required elements and influence the model stability. Furthermore, the implementation of faults often leads to artifacts and can therefore reduce the accuracy of the model results. Due to these limitations it is frequently necessary to distinguish between faults that are crucial for the model as they influence the stresses in magnitude and orientation on a large scale and faults that will only influence the model on a local scale and may therefore be neglected on a regional perspective. The impact of faults on a geomechanical model depends on various different factors such as geometry and mechanical properties of the fault itself, the tectonic regime or the scale of the model. As the relevance of a fault for a geomechanical model is not necessarily identical to its relevance in other geoscientific fields it can be challenging to identify relevant faults.The SpannEnD project focuses on the generation of a 3-D geomechanical model of Germany and adjacent areas in the context of the disposal of nuclear waste in order to predict the tectonic stresses in areas without stress data. There is a multitude of faults known in the modelling area but due to their sheer amount not all faults can be incorporated. Criteria have to be found that drastically reduce the number of faults while keeping the change in the geomechanical stress pattern to a minimum. We will present different criteria that can be used for the fault selection which have being worked out in the framework of the SpannEnD project.

Published
2020

15. Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort

Author

GUARD C, Study Group, Hassanein, T, Bakalos, G, Ahlers, S, Shiffman, Ml, Tallarico, L, Reddy, Kr, Orlandini, A, Ferenci, P, Derbala, M, Coppola, C, Foster, Gr, Basho, J, Shabanaj, G, Harxhi, A, Debzi, N, Afredj, N, Guessab, N, Mahindad, N, Mahiou, H, Aissaoui, M, Al Qameesh, J, Al Ghandoor, Z, Assene, C, Bastens, B, Brixko, C, Cool, M, De Galocsy, C, Delwaide, J, George, C, Laukens, P, Lefebvre, V, Mulkay, Jp, Nevens, F, Servais, B, Van Vlierberghe, H, Horsmans, Y, Henrion, J, Sprengers, D, Michielsen, P, Bourgeois, S, Lasser, L, Langlet, P, Robaeys, G, Martinet, Jp, Warzee, P, Hoste, P, Reynaert, H, Juriens, I, Decaestecker, J, Van Der Meersch, F, Janssens, F, Ahmetagic, S, Verhaz, A, Bevanda, M, Calkic, L, Ibrahimpasic, N, Mesihovic, R, Mello, Ce, Ruiz, Fj, Martins Junior, E, Ferraz, Ml, Silva, G, Mendes, C, Lyra, A, Silva, Mh, Gomide, G, Fernandes, Jc, Pereira, P, Correa, Mc, Teixeira, R, Yousry, A, Hanno, A, Gabr, M, Omar, A, Esmat, G, Karatapanis, S, Nikolopoulou, V, Giannoulis, G, Manolakopoulos, S, Elefsiniotis, I, Drakoulis, C, Dimitroulopoulos, D, Kanatakis, S, Ketikoglou, I, Mimidis, K, Evgenidis, N, Akriviades, E, Vafiadi Zoubouli, I, Tsianos, E, Mela, M, Orfanou, E, Mousoulis, G, Karagiannis, I, Manesis, E, Varga, M, Nemesánszky, E, Fried, K, Schuller, J, Szalay, F, Lengyel, G, Tornai, I, Banyai, T, Lesch, M, Nagy, I, Gervain, J, Tusnadi, A, Schneider, F, Szentgyörgyi, L, Hunyady, B, Vincze, A, Tolvaj, G, Varkonyi, I, Makkai, E, Enyedi, J, Racz, I, Hausinger, P, Váczi, Z, Patai, Á, Ozsvár, Z, Lakner, L, Ribiczey, P, Bhalla, A, Somani, S, Luaia, R, Rao, P, Philip, M, Lawate, P, Nagral, A, Sood, A, Parikh, S, Merat, S, Nassiri Toosi, M, Alavian, Sm, Zali, Mr, Daryani, Ne, Drenaggi, D, Attili, Af, Bandiera, F, Bassi, P, Bellati, G, Bellantani, S, Brunetto, MAURIZIA ROSSANA, Bruno, S, Castelli, F, Castellacci, R, Cattelan, Am, Colombo, M, Craxi, A, D'Angelo, S, Colombo, S, Demelia, L, Di Perri, G, Di Giacomo, A, Ferrari, C, Francisci, D, Casinelli, K, Ganga, R, Costa, C, Mangia, A, Russo, Fp, Matarazzo, F, Mazzella, G, Mazzeo, M, Memoli, M, Montalbano, M, Montalto, G, Pieri, A, Passariello, N, Picciotto, A, Pietrangelo, A, Pirisi, M, Quirino, T, Raimondo, G, Rapaccini, Gl, Rizzardini, G, Rizzetto, M, Russello, M, Sabusco, G, Santantonio, T, Soardo, G, Amedea, A, Verucchi, G, Vinelli, F, Zignego, Al, Zuin, M, Ascione, A, Vinci, M, Pigozzi, Mg, Tundo, P, Saracco, Gm, Amoroso, P, Andreoni, M, Colletta, C, Erne, E, Megna, As, Biglino, A, Chiriaco, P, Foti, G, Spinzi, G, D'Amico, E, Paik, Sw, Ahn, Sh, Lee, Yn, Kim, Y, Yang, J, Han, Sy, Varghese, R, Al Gharabally, A, Askar, H, Sharara, A, Yaghi, C, Rached, Aa, Houmani, Z, Zaarour, F, Dohaibi, A, Ivanovski, L, Joksimovic, N, Abbas, Z, Memon, S, Mohsin, A, Masood, S, Hashmi, Z, Halota, W, Deron, Z, Mazur, W, Flisiak, R, Lipczynski, A, Musialik, J, Piekarska, A, Augustyniak, K, Baka Cwierz, B, Simon, K, Gietka, A, Berak, H, Sieklucki, J, Radowska, D, Szlauer, B, Piekos, T, Olszok, I, Jablkowski, M, Orszulak, G, Warakomska, I, Aleixo, Mj, Valente, C, Macedo, G, Sarmento Castro, R, Roxo, F, Faria, T, Mansinho, K, Velez, J, Ramos, Jp, Guerreiro, H, Alberto, S, Monteverde, C, Serejo, F, Peixe, P, Malhado, J, Curescu, M, Streinu Cercel, A, Caruntu, F, Livia, H, Preotescu, L, Arama, V, Ancuta, I, Gheorghe, L, Stanciu, C, Trifan, A, Acalovschi, M, Andreica, V, Pascu, O, Lencu, M, Sporea, I, Olteanu, D, Ionita Radu, F, Fierbinteanu Braticevici, C, Motoc, A, Silaghi, R, Musat, M, Coman, F, Stan, M, Cijevschi, C, Miftode, E, Delic, D, Jesic, R, Nozic, D, Svorcan, P, Fabri, M, Konstantinovic, L, Pelemis, M, Jankovic, G, Todorovic, Z, Nagorni, A, Kupcova, V, Skladany, L, Szantova, M, Krkoska, D, Jarcuska, P, Schreter, I, Oltman, M, Bocakova, J, Bunganic, I, Holoman, J, Giguere, A, Abdou, A. M., Basic (bio-) Medical Sciences, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, Liver Cell Biology, Michielsen, Peter, GUARD-C Study Group, Graham R. Foster, Carmine Coppola, Moutaz Derbala, Peter Ferenci, Alessandra Orlandini, K. Rajender Reddy, Ludovico Tallarico, Mitchell L. Shiffman, Silke Ahler, Georgios Bakalo, Tarek Hassanein, GUARD-C Study Group: [.., Davide Drenaggi, Adolfo Francesco Attili, Franco Bandiera, Paolo Bassi, Giorgio Bellati, Stefano Bellantani, Maurizia Brunetto, Savino Bruno, Francesco Castelli, Roberto Castellacci, Anna Maria Cattelan, Massimo Colombo, Antonio Craxi, Salvatore D'angelo, Silvia Colombo, Luigi Demelia, Giovanni Di Perri, Antonio Di Giacomo, Carlo Ferrari, Daniela Francisci, Katia Casinelli, Roberto Ganga, Chiara Costa, Alessandra Mangia, Francesco Paolo Russo, Filippo Matarazzo, Giuseppe Mazzella, Maurizio Mazzeo, Massimo Memoli, Marzia Montalbano, Giuseppe Montalto, Alessandro Pieri, Nicola Passariello, Antonio Picciotto, Antonello Pietrangelo, Mario Pirisi, Tiziana Quirino, Giovanni Raimondo, Gian Ludovico Rapaccini, Giuliano Rizzardini, Mario Rizzetto, Maurizio Russello, Giuseppe Sabusco, Teresa Santantonio, Giorgio Soardo, Alessandri Amedea, Gabriella Verucchi, Francesco Vinelli, Anna Linda Zignego, Massimo Zuin, Antonio Ascione, Maria Vinci, Maria Graziella Pigozzi, Paolo Tundo, Giorgio Maria Saracco, Pietro Amoroso, Massimo Andreoni, Cosimo Colletta, Elke Erne, Angelo Salomone Megna, Alberto Biglino, Piergiorgio Chiriaco, Giuseppe Foti, Giancarlo Spinzi, Emilio D'amico, …], Foster G.R., Coppola C., Derbala M., Ferenci P., Orlandini A., Reddy K.R., Tallarico L., Shiffman M.L., Ahlers S., Bakalos G., Hassanein T., Basho J., Shabanaj G., Harxhi A., Debzi N., Afredj N., Guessab N., Mahindad N., Mahiou H., Aissaoui M., Al Qameesh J., Al Ghandoor Z., Assene C., Bastens B., Brixko C., Cool M., De Galocsy C., Delwaide J., George C., Laukens P., Lefebvre V., Mulkay J.-P., Nevens F., Servais B., Van Vlierberghe H., Horsmans Y., Henrion J., Sprengers D., Michielsen P., Bourgeois S., Lasser L., Langlet P., Robaeys G., Martinet J.-P., Warzee P., Hoste P., Reynaert H., Juriens I., Decaestecker J., Van Der Meersch F., Janssens F., Ahmetagic S., Verhaz A., Bevanda M., Calkic L., Ibrahimpasic N., Mesihovic R., Mello C.E., Ruiz F.J., Junior E.M., Ferraz M.L., Silva G., Mendes C., Lyra A., Silva M.H., Gomide G., Fernandes J.C., Pereira P., Correa M.C., Teixeira R., Yousry A., Hanno A., Gabr M., Omar A., Esmat G., Karatapanis S., Nikolopoulou V., Giannoulis G., Manolakopoulos S., Elefsiniotis I., Drakoulis C., Dimitroulopoulos D., Kanatakis S., Ketikoglou I., Mimidis K., Evgenidis N., Akriviades E., Vafiadi-Zoubouli I., Tsianos E., Mela M., Orfanou E., Mousoulis G., Karagiannis I., Manesis E., Varga M., Nemesanszky E., Fried K., Schuller J., Szalay F., Lengyel G., Tornai I., Banyai T., Lesch M., Nagy I., Gervain J., Tusnadi A., Schneider F., Szentgyorgyi L., Hunyady B., Vincze A., Tolvaj G., Varkonyi I., Makkai E., Enyedi J., Racz I., Hausinger P., Vaczi Z., Patai A., Ozsvar Z., Lakner L., Ribiczey P., Bhalla A., Somani S., Luaia R., Rao P., Philip M., Lawate P., Nagral A., Sood A., Parikh S., Merat S., Nassiri-Toosi M., Alavian S.-M., Zali M.R., Daryani N.E., Drenaggi D., Attili A.F., Bandiera F., Bassi P., Bellati G., Bellantani S., Brunetto M., Bruno S., Castelli F., Castellacci R., Cattelan A.M., Colombo M., Craxi A., D'angelo S., Colombo S., Demelia L., Di Perri G., Di Giacomo A., Ferrari C., Francisci D., Casinelli K., Ganga R., Costa C., Mangia A., Russo F.P., Matarazzo F., Mazzella G., Mazzeo M., Memoli M., Montalbano M., Montalto G., Pieri A., Passariello N., Picciotto A., Pietrangelo A., Pirisi M., Quirino T., Raimondo G., Rapaccini G.L., Rizzardini G., Rizzetto M., Russello M., Sabusco G., Santantonio T., Soardo G., Amedea A., Verucchi G., Vinelli F., Zignego A.L., Zuin M., Ascione A., Vinci M., Pigozzi M.G., Tundo P., Saracco G.M., Amoroso P., Andreoni M., Colletta C., Erne E., Megna A.S., Biglino A., Chiriaco P., Foti G., Spinzi G., D'amico E., Paik S.W., Ahn S.-H., Lee Y.N., Kim Y., Yang J., Han S.Y., Varghese R., Al Gharabally A., Askar H., Sharara A., Yaghi C., Abou Rached A., Houmani Z., Zaarour F., Dohaibi A., Ivanovski L., Joksimovic N., Abbas Z., Memon S., Mohsin A., Masood S., Hashmi Z., Halota W., Deron Z., Mazur W., Flisiak R., Lipczynski A., Musialik J., Piekarska A., Augustyniak K., Baka-Cwierz B., Simon K., Gietka A., Berak H., Sieklucki J., Radowska D., Szlauer B., Piekos T., Olszok I., Jablkowski M., Orszulak G., Warakomska I., Aleixo M.J., Valente C., Macedo G., Sarmento-Castro R., Roxo F., Faria T., Mansinho K., Velez J., Ramos J.P., Guerreiro H., Alberto S., Monteverde C., Serejo F., Peixe P., Malhado J., Curescu M., Streinu-Cercel A., Caruntu F., Livia H., Preotescu L., Arama V., Ancuta I., Gheorghe L., Stanciu C., Trifan A., Acalovschi M., Andreica V., Pascu O., Lencu M., Sporea I., Olteanu D., Ionita-Radu F., Fierbinteanu-Braticevici C., Motoc A., Silaghi R., Musat M., Coman F., Stan M., Cijevschi C., Miftode E., Delic D., Jesic R., Nozic D., Svorcan P., Fabri M., Konstantinovic L., Pelemis M., Jankovic G., Todorovic Z., Nagorni A., Kupcova V., Skladany L., Szantova M., Krkoska D., Jarcuska P., Schreter I., Oltman M., Bocakova J., Bunganic I., Holoman J., Giguere A., Abdou A.M.S., UCL - SSS/IREC-Institut de recherche expérimentale et clinique, UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie, and UCL - (SLuc) Service de gastro-entérologie

Subjects
Genetics and Molecular Biology (all), Male, Chronic Hepatitis, Hepacivirus, Ribavirin/adverse effects, Asthenia/chemically induced, Polyethylene Glycol, Biochemistry, Polyethylene Glycols, Body Mass Index, Chronic Liver Disease, 0302 clinical medicine, Neutropenia/chemically induced, Interferon-alpha/adverse effects, Medicine, Chronic, lcsh:Science, Liver Diseases, virus diseases, Antiviral Agents/adverse effects, Cohort, Science & Technology - Other Topics, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Cohort study, Human, medicine.medical_specialty, Alpha interferon, Gastroenterology and Hepatology, Antiviral Agents, Microbiology, Dose-Response Relationship, 03 medical and health sciences, Pharmacotherapy, Hepatitis C, Chronic/drug therapy, Dose Prediction Methods, Drug Therapy, Anemia/chemically induced, Humans, Hemoglobin, Aged, Medicine and health sciences, Biochemistry, Genetics and Molecular Biology (all), Hepaciviru, Science & Technology, Dose-Response Relationship, Drug, Flaviviruses, lcsh:R, Organisms, Biology and Life Sciences, Proteins, medicine.disease, digestive system diseases, chemistry, Agricultural and Biological Sciences (all), Withholding Treatment, Asthenia, Immunology, Proportional Hazards Model, lcsh:Q, Human medicine, RNA viruses, Physiology, lcsh:Medicine, Peginterferon-alfa, Polyethylene Glycols/adverse effects, Adult, Anemia, Cohort Studies, Female, Hepatitis C, Chronic, Host-Pathogen Interactions, Interferon-alpha, Middle Aged, Neutropenia, Outcome Assessment (Health Care), Proportional Hazards Models, RNA, Viral, Recombinant Proteins, Ribavirin, Medicine (all), chemistry.chemical_compound, Outcome Assessment, Health Care, Medicine and Health Sciences, 030212 general & internal medicine, Viral, Pathology and laboratory medicine, Multidisciplinary, biology, Hepatitis C virus, Pharmaceutics, Hepatitis C, Hematology, Recombinant Protein, Outcome Assessment (Health Care)/methods, Medical microbiology, Host-Pathogen Interaction, Multidisciplinary Sciences, Physiological Parameters, Research Design, Combination, Viruses, Drug, Pathogens, Host-Pathogen Interactions/drug effects, Research Article, Clinical Research Design, Research and Analysis Methods, Internal medicine, Recombinant Proteins/adverse effects, RNA, Viral/blood, Antiviral Agent, business.industry, Body Weight, Hepacivirus/drug effects, Viral pathogens, biology.organism_classification, Hepatitis viruses, Microbial pathogens, RNA, Adverse Events, Cohort Studie, business
Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Published
2015

19. Landelijke standaard ketenzorg antistolling en Leidraad begeleide introductie nieuwe orale antistollingsmiddelen - Inventariserend onderzoek naar implementatie in ziekenhuizen

Author

Wiltink, E. H H, Koster, E. S., Ahlers, S. J G M, Sub Pharmacoepidemiology, Sub UPPER, Universiteit Utrecht, Sub Gen. Pharmacoepi and Clinical Pharm, and Pharmacoepidemiology and Clinical Pharmacology

Subjects
Pharmacology, Pharmacology (medical)
Abstract

OBJECTIVE: To investigate the current state of knowledge and implementation of two new directives. After the release of new directives it will take some time before everyone is aware of them and implementation is achieved. Implementation of the Nationwide standard of continuous care of anticoagulation and the Directive for regulated introduction of new oral anticoagulants was investigated in the hospital setting six months after release. DESIGN AND METHODS Structured questionnaires were used to interview hospital pharmacists and specialists involved in prescribing anticoagulant drugs. RESULTS: In total, 27 hospital pharmacists and 48 specialists participated. In general the standard and directive are better known by hospital pharmacists than by specialists. The implementation of parts of the standard, especially some indicators, are lagging behind and need extra attention. CONCLUSION: Many hospitals have started the implementation of standard and directive but it will take more time to fully implement them.

Published
2015

21. Diffuse x-ray scattering from inclusions in ferromagnetic Ge1-xMnx layers

Author

Holy, V., Lechner, R. T., Ahlers, S., Horyk, L., Metzger, T. H., Navarro-Quezada, A., Trampert, A., Bougeard, Dominique, and Bauer, G.

Subjects
ddc:530, 530 Physik
Abstract

Magnetic properties of Ge1-xMnx epitaxial layers with a Mn content of a few percents are substantially influenced by inhomogeneities in the distribution of Mn atoms in the Ge lattice. Depending on the substrate temperature during molecular-beam epitaxial fabrication, apparently cubic, coherent Mn-rich clusters or incoherent precipitates consisting of the hexagonal, intermetallic Mn5Ge3 phase can occur in a defect free, diamond lattice Ge matrix. In this work, we apply synchrotron x-ray diffraction in grazing-incidence geometry to probe the diffuse scattered intensity of the distorted Ge host lattice. Based on a theoretical description of the scattered intensity we derive quantitative information on the lattice mismatch between the Mn inclusions and the Ge lattice, as well as on the average size of the inclusions and the average Mn content within the inclusions.

Published
2008
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22. Magnetic and structural properties of GexMn1-x films: Precipitation of intermetallic nanomagnets

Author

Ahlers, S., Bougeard, Dominique, Sircar, N., Abstreiter, Gerhard, Trampert, A., Opel, M., and Gross, R.

Subjects
Condensed Matter::Materials Science, ddc:530, 530 Physik
Abstract

We present a comprehensive study relating the nanostructure of Ge0.95Mn0.05 films to their magnetic properties. The formation of ferromagnetic nanometer-sized inclusions in a defect-free Ge matrix fabricated by low-temperature molecular beam epitaxy is observed down to substrate temperatures T-S as low as 70 degrees C. A combined transmission electron microscopy and electron energy-loss spectroscopy analysis of the films identifies the inclusions as precipitates of the ferromagnetic compound Mn5Ge3. The volume and amount of these precipitates decrease with decreasing T-S. Magnetometry of the films containing precipitates reveals distinct temperature ranges: Between the characteristic ferromagnetic transition temperature of Mn5Ge3 at approximately room temperature and a lower, T-S-dependent blocking temperature T-B the magnetic properties are dominated by superparamagnetism of the Mn5Ge3 precipitates. Below T-B, the magnetic signature of ferromagnetic precipitates with blocked magnetic moments is observed. At the lowest temperatures, the films show features characteristic of a metastable state.

Published
2006
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23. Selecting first-line bevacizumab-containing therapy for advanced breast cancer: TURANDOT risk factor analyses

Author

Brodowicz, T, primary, Lang, I, additional, Kahan, Z, additional, Greil, R, additional, Beslija, S, additional, Stemmer, S M, additional, Kaufman, B, additional, Petruzelka, L, additional, Eniu, A, additional, Anghel, R, additional, Koynov, K, additional, Vrbanec, D, additional, Pienkowski, T, additional, Melichar, B, additional, Spanik, S, additional, Ahlers, S, additional, Messinger, D, additional, Inbar, M J, additional, and Zielinski, C, additional

Published
2014
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25. P1126 IMPACT OF SAFETY-RELATED DOSE REDUCTIONS AND DISCONTINUATIONS (SR-RD) ON SUSTAINED VIROLOGICAL RESPONSE (SVR) IN TREATMENT-NAIVE CHRONIC HEPATITIS C PATIENTS RECEIVING PEGINTERFERON ALFA-2a/RIBAVIRIN: RESULTS FROM GUARD-C

Author

Foster, G.R., primary, Coppola, C., additional, Curescu, M., additional, Derbala, M., additional, Esmat, G., additional, Ferenci, P., additional, Flisiak, R., additional, Lengyel, G., additional, Mangia, A., additional, Orlandini, A., additional, Reddy, K.R., additional, Rodriguez-Torres, M., additional, Shiffman, M.L., additional, Sporea, I., additional, Tallarico, L., additional, Ahlers, S., additional, Bakalos, G., additional, Wat, C., additional, and Hassanein, T., additional

Published
2014
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26. Abstract P6-06-40: Analysis of outcome according to risk factors in the randomized phase III TURANDOT trial evaluating first-line bevacizumab-containing therapy for HER2-negative locally recurrent/metastatic breast cancer (LR/mBC)

Author

Brodowicz, T, primary, Pienkowski, T, additional, Beslija, S, additional, Melichar, B, additional, Lang, I, additional, Inbar, MJ, additional, Anghel, R, additional, Spanik, S, additional, Ahlers, S, additional, and Zielinski, C, additional

Published
2013
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27. Efficacy of an intravenous bolus of morphine 2.5 versus morphine 7.5 mg for procedural pain relief in postoperative cardiothoracic patients in the intensive care unit: a randomised double-blind controlled trial.

Author

Ahlers S, van Gulik L, van Dongen E, Bruins P, van de Garde E, van Boven W, Tibboel D, Knibbe C, Ahlers, S J G M, van Gulik, L, van Dongen, E P A, Bruins, P, van de Garde, E M W, van Boven, W J, Tibboel, D, and Knibbe, C A J

Abstract

As pain in the intensive care unit (ICU) is still common despite important progress in pain management, we studied the efficacy of an intravenous bolus of morphine 2.5 vs 7.5 mg for procedural pain relief in patients after cardiothoracic surgery in the ICU. In a prospective double-blind randomised study, 117 ICU patients after cardiothoracic surgery were included. All patients were treated according a pain titration protocol for pain at rest, consisting of continuous morphine infusions and paracetamol, applied during the entire ICU stay. On the first postoperative day, patients were randomised to intravenous morphine 2.5 (n=59) or 7.5 mg (n=58) 30 minutes before a painful intervention (turning of patient and/or chest drain removal). Pain scores using the numeric rating scale (Numeric Rating Scale, range 0 to 10) were rated at rest (baseline) and around the painful procedure. At rest (baseline), overall incidence of unacceptable pain (Numeric Rating Scale ≥4) was low (Numeric Rating Scale >4; 14 vs 17%, P=0.81) for patients allocated to morphine 2.5 and 7.5 mg respectively. For procedure-related pain, there was no difference in incidence of unacceptable pain (28 vs 22%, P=0.53) mean pain scores (2.6 [95% confidence interval 2.0 to 3.2] vs 2.7 [95% confidence interval 2.0 to 3.4]) between patients receiving morphine 2.5 and 7.5 mg respectively. In intensive care patients after cardiothoracic surgery with low pain levels for pain at rest, there was no difference in efficacy between intravenous morphine 2.5 mg or morphine 7.5 mg for pain relief during a painful intervention. [ABSTRACT FROM AUTHOR]

Published
2012
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30. 1110 BASELINE PREDICTORS FOR SAFETY-RELATED DOSE REDUCTIONS OR TREATMENT DISCONTINUATIONS AMONG PEGINTERFERON ALFA-2A (40KD)/RIBAVIRIN-TREATED PATIENTS AND THEIR IMPACT ON EARLY TREATMENT RESPONSES: GUARD-C INTERIM ANALYSIS

Author

Foster, G.R., primary, Coppola, C., additional, Derbala, M.F., additional, Ferenci, P., additional, Orlandini, A., additional, Tallarico, L., additional, Ahlers, S., additional, Tatsch, F., additional, and Hassanein, T., additional

Published
2012
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37. Innate Immune Responses in Swine Resuscitated from Severe Traumatic Hemorrhagic Shock with Hemoglobin-Based Oxygen Carrier-201

Author

Hall, C., primary, Malkevich, N., additional, Handrigan, M., additional, VanderMolen, C., additional, Aranaud, F., additional, Hong, J., additional, Dong, F., additional, Rice, J., additional, Philbin, N., additional, Ahlers, S., additional, McCarron, R., additional, Freilich, D., additional, McGwin, G., additional, Flournoy, W. S., additional, and Bruce Pearce, L., additional

Published
2007
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38. Immune Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers (HBOC) in a Swine Model of Severe Controlled Hemorrhagic Shock

Author

VanderMolen, C., primary, Malkevich, N., additional, Philbin, N., additional, Rice, J., additional, Collier, S., additional, Hall, C., additional, Ahlers, S., additional, McCarron, R., additional, Freilich, D., additional, McGwin, G., additional, and Pearce, L. Bruce, additional

Published
2007
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39. Reading performance of geriatric patients post exudative maculopathy

Author

Stelmack J, Reda D, Ahlers S, Bainbridge L, and McCray J

Subjects
Aged, 80 and over, Macular Degeneration, Eyeglasses, Reading, Sensory Aids, Humans, Vision, Low, Television, Exudates and Transudates, Middle Aged, Eye Infections, Fungal, Histoplasmosis, Aged
Abstract

This study was performed to evaluate any differences in reading speed and duration of comfortable reading speed in geriatric patients with post disciform stage exudative age-related macular degeneration (ARMD) or ocular histoplasmosis. Reading speed and duration with CCTV, illuminated stand magnifier, and spectacle lenses were compared for 37 patients in the Low Vision Program at the Central Blind Rehabilitation Center. Results indicate significantly faster reading speed with CCTV and spectacle lenses as compared to illuminated stand magnifiers. The difference between reading speeds measured with spectacle reading glasses and CCTVs was borderline significant. Patients read significantly longer with CCTVs than with spectacle lenses or illuminated stand magnifiers. No significant difference was found comparing spectacle lenses or illuminated stand magnifiers with regard to reading duration.

Published
1991

44. Direct propanol synthesis from CO2, C2H4, and H2over Cs–Au/TiO2rutile: effect of promoter loading, temperature and feed compositionElectronic supplementary information (ESI) available: HAADF-STEM images, XRD & XPS analysis, and further catalytic data. See DOI: 10.1039/c5cy01425e

Author

Ahlers, S. J., Pohl, M.-M., Holena, M., Linke, D., and Kondratenko, E. V.

Abstract

Cs–Au/TiO2rutile catalysts have been prepared and tested for the direct synthesis of n-propanol from CO2in the presence of C2H4and H2. Irrespective of the Cs loading, two kinds of Au particles, i.e.Au nanoparticles (NPs) around 4 nm to 8 nm and below 2 nm (even atomic gold), were identified on the surface of the catalysts. No direct relationship between the size and propanol production was established, while Cs loading strongly affected these catalyst properties. HAADF-STEM and EDX proved that Cs was homogenously distributed on both TiO2and Au NPs and favoured stabilisation of the Auδ+species. Such species were suggested to increase the rate of CO insertion into C2H4thus improving the selectivity to propanol. In addition to Cs loading, the temperature and the H2/CO2, H2/C2H4and CO2/C2H4ratios also affected both desired (propanol formation) and undesired (C2H4hydrogenation to C2H6) reaction pathways. The conversion of CO2increased with an increase in the temperature from 473 K to 543 K, while the conversion of C2H4was practically not affected but the selectivity to propanol decreased from 100% to around 30%. For all temperatures, the catalyst performance depended on the H2/(CO2+ C2H4) ratio. Based on the obtained results, optimal reaction conditions for propanol synthesis were identified.

Published
2016
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48. A solid-state gas sensor array for monitoring NOx storage catalytic converters

Author

Schalwig, J., Ahlers, S., Kreisl, P., Bosch-v. Braunmühl, C., and Müller, G.

Subjects
*METALLIC oxides, *FERROELECTRIC thin films, *GAS detectors, *CATALYTIC converters for automobiles
Abstract

Aiming at better fuel economy, the automotive industry makes increasing use of so-called lean-burn engines. Exhaust gases emerging from such engines need to be treated in NOx storage catalysts to comply with the low NOx emission standards prescribed by the legislation. Monitoring and controlling the state of filling and regeneration of NOx storage catalysts in turn requires the use of novel kinds of gas sensing devices besides the usual switching λ probes, widely used in the car industry. In the present paper, we would like to show that the filling and regeneration of NOx storage catalysts could be monitored with the help of simple two-sensor arrays consisting of: (i) a SiC-based field-effect gas sensor with a catalytic Pt gate (Pt-MOSiC), and (ii) a resistive thin-film metal oxide gas sensor. Measurements in a gas test rig reveal that both kinds of sensors exhibit significant levels of cross-sensitivity, responding in principle to all kinds of exhaust gas components. A more detailed comparison, however, shows that the main sensitivities of Pt-MOSiC sensors are more heavily biased towards reducing exhaust gas components, whereas resistive metal oxide gas sensors detect more sensitively oxidizing components. Experiments on a motor test bench reveal that these two kinds of sensors are sufficiently complementary in their gas sensing properties to provide a very clear and detailed picture of the momentary state of filling and of regeneration of a NOx storage catalyst. [Copyright &y& Elsevier]

Published
2004
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49. Response mechanism of SiC-based MOS field-effect gas sensors.

Author

Schalwig, J., Kreisl, P., Ahlers, S., and Muller, G.

Abstract

SiC-based field-effect gas sensors with catalytic platinum electrodes (Pt-MOSiC) have been subjected to a series of gas response measurements. Structural analysis of the Pt electrodes revealed that the gas sensitivity and the selectivity of Pt-MOSiC gas sensors depend on two major parameters: the porosity and the catalytic activity of the Pt electrodes. Pt-MOSiC gas sensors with thick, dense Pt electrodes only exhibit hydrogen sensitivity, whereas Pt-MOSiCs with thin porous gates exhibit a broad range of gas sensitivities similar to resistive metal-oxide gas sensors. A model is put forward that explains the nonhydrogen gas response of Pt-MOSiC devices and of conventional polycrystalline metal-oxide materials on a common basis. [ABSTRACT FROM PUBLISHER]

Published
2002
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50. Suppression of Root Rot on Peas, Beans and Beetroots Caused by <em>Pythium ultimum</em> and <em>Rhizoctonia solani</em> through the Amendment of Growing Media with Composted Organic Household Waste.

Author

Schuler, C., Vogtmann, H., Gottschall, R., Biala, J., Bruns, C., and Ahlers, S.

Subjects
ROOT rots, SOILBORNE plant pathogens, PYTHIUM ultimum, RHIZOCTONIA solani, COMPOSTING, PLANT diseases
Abstract

In pot experiments under controlled environmental conditions, composted organic household waste showed a suppression of soilborne plant pathogens. The addition of 8 %, 10 % and 30 % compost to the potting material which was artificially infested with Pythium ultimum or Rhizoctonia solani considerably reduced the incidence of disease in different varieties of host plants. It became evident that the degree of protection provided by compost depends upon the amount of compost added and upon the vulnerability of the host plant to infection. In an experiment using increasing levels of inoculum, the compost proved suppressive to the pathogen even under extreme disease conditions. This suppressive effect was still evident in compost which had been stored for prolonged periods. [ABSTRACT FROM AUTHOR]

Published
1989
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