115 results on '"Ajay Pillai"'
Search Results
2. An Unusual Complication of Transseptal Puncture
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Ajay Pillai, MD, Santosh K. Padala, MD, Kenneth A. Ellenbogen, MD, and Jayanthi N. Koneru, MBBS
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atrial fibrillation ,complication ,electrophysiology ,pericardial effusion ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The interatrial septum is a structure with complex embryological development. The true atrial septum is a circumscribed structure, and transgression outside of this area during transseptal puncture may result in entry into the extracardiac space or aorta that may result in a pericardial effusion or cardiac tamponade. (Level of Difficulty: Intermediate.)
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- 2021
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3. Eosinophilic Granulomatosis With Polyangiitis Presenting as an Acute Coronary Syndrome
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Jeffrey Kolominsky, MD, Zackary Tushak, DO, Jaideep Patel, MD, Aaron Schatz, MD, Ajay Pillai, MD, and Jonathan Potfay, MD
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acute coronary syndrome ,EGPA ,eosinophilia ,ischemic heart disease ,premature coronary artery disease ,vasculitis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss Syndrome, is an uncommon disorder that carries a high mortality when coronary artery disease develops. Early recognition and treatment is crucial. We highlight an unusual presentation of acute coronary syndrome not associated with atherosclerotic coronary disease. (Level of Difficulty: Intermediate.)
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- 2020
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4. Prevalence and pattern of lobular capillary hemangioma in Eastern Madhya Pradesh, India: A clinicopathological analysis
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Divashree Sharma, Geeta Mishra Tripathi, Sourabh Dixit, Ajay Pillai, and Shaji Thomas
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Excision ,lobular capillary hemangioma ,pregnancy tumor ,pyogenic granuloma ,Dentistry ,RK1-715 - Abstract
Background: Lobular capillary hemangioma is a common benign vascular tumor seen in the oral cavity. It occurs in response to various stimuli such as low-grade local irritation, traumatic insult, and hormonal factors or as a response to a wide variety of drugs. Materials and Methods: All patients presenting to the Department of Dentistry, Shyam Shah Medical College, Rewa, Madhya Pradesh during July 2014 to June 2016, who were diagnosed by histopathologic confirmation as oral lobular capillary hemangioma (OLCH), were evaluated for the area involved, clinicopathologic presentation, demographic features, and treatment. Results: A total of 94 cases were identified as OLCH by histopathologic confirmation during this period. The lesion occurred most commonly in the age group of 21–30 years. A characteristic female predominance (female: male ratio of 2.24:1) was seen. Anterior maxillary labial gingiva was most frequently involved (34.04%) followed by posterior maxillary buccal gingiva (14.89%). Conclusion: The clinicopathologic picture of OLCH found in this study was similar to other studies conducted on same as well different ethnic and geographical populations. Poor oral-dental-hygiene was observed in majority of patients (87.23%) dental health education should be an integral component of imparting oral health care by health providers. Surgical excision as a treatment modality renders good results with low recurrence rate.
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- 2017
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5. Two Dentigerous Cysts in 12 Years Old Children: Report of an Unusual Case
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Geeta Mishra Tripathi, Shaji Thomas, N S Gautam, and Ajay Pillai
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Children ,Dentigerous cyst ,Non syndromic. ,Biology (General) ,QH301-705.5 - Abstract
Background: Dentigerous cysts are common cysts of the jaws. They are associated with the crowns of permanent teeth, most frequently associated with impacted mandibular third molars. The other teeth that are commonly affected are, in order of frequency, the maxillary canines, the maxillary third molars and, rarely, the central incisor. Radiographically, the cyst appears as ovoid well-demarcated unilocular radiolucency with a sclerotic border. The present case reports describes the surgical enucleation of a 2 dentigerous cysts involving the lower permanent canine and upper premolar of maxilla in 12 years old nonsyndromic children.
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- 2014
6. Natural Teeth Replacing Artificial Teeth in a Partial Denture: A Case Report
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Sukanta Kumar Satapathy, Ajay Pillai, Ramya Jyothi, and P. Durga Annapurna
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immediate partial denture ,natural teeth ,aesthetics ,Medicine - Abstract
The aesthetic replacement of anterior teeth in cases of immediate partial denture is always a challenging work for prosthodontists. There is always problem of matching size, colour, shade and shape of the replaced tooth with those of the natural teeth. It was most difficult to satisfy the patients who have high aesthetic demands. Here is a report of a case where patient’s own natural tooth was used for replacement in an immediate partial denture. An immediate denture is defined as “any removable dental prosthesis which is fabricated for placement immediately, following the removal of a natural tooth/teeth”. Patients with missing anterior teeth lack an impressive appearance aesthetically and as well as psychologically. Tooth loss leads to a certain degree of loss of function. This loss of function might lead to an impairment of oral health which is related to quality of life. An immediate denture can replace 1-16 teeth in either the maxillary or the mandibular arch, or in both arches. The need for the immediate replacement of a missing tooth is more in case of an anterior tooth, where aesthetics is of prime concern. The replacement of an anterior tooth is most technique sensitive, as it includes the patient’s expectations, which include, matching with proper shade, shape and size as those of his/her natural teeth. So, here is a case presentation where modern day patient expectations were taken into consideration.
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- 2013
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7. Pharos 2023: an integrated resource for the understudied human proteome.
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Keith J. Kelleher, Timothy Sheils, Stephen L. Mathias, Jeremy J. Yang, Vincent T. Metzger, Vishal B. Siramshetty, Dac-Trung Nguyen, Lars Juhl Jensen, Dusica Vidovic, Stephan C. Schürer, Jayme Holmes, Karlie R. Sharma, Ajay Pillai, Cristian Bologa, Jeremy S. Edwards, Ewy A Mathé, and Tudor I. Oprea
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- 2023
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8. Another Aid For Difficult Intubation.
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Sandeep Chauhan, Manoranjan Sahoo, Ajay Pillai, Minati Choudhary, and Nita Saxena
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Anesthesiology ,RD78.3-87.3 - Published
- 2002
9. piNET: a versatile web platform for downstream analysis and visualization of proteomics data.
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Behrouz Shamsaei, Szymon Chojnacki, Marcin Pilarczyk, Mehdi Fazel-Najafabadi, Wen Niu, Chuming Chen, Karen Ross, Andrea Matlock, Jeremy Muhlich, Somchai Chutipongtanate, Jie Zheng 0001, John Turner, Dusica Vidovic, Jake Jaffe, Michael J. MacCoss, Cathy Wu 0001, Ajay Pillai, Avi Ma'ayan, Stephan C. Schürer, Michal Kouril, Mario Medvedovic, and Jarek Meller
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- 2020
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10. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program.
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Michael P. Snyder, Shin Lin, Amanda Posgai, Mark Atkinson, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury, Nicholas A. Nystrom, Jonathan C. Silverstein, Ziv Bar-Joseph, Kun Zhang 0020, Katy Börner, Yiing Lin, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Long Cai, Cole Trapnell, Dana Jackson, Garry P. Nolan, William James Greenleaf, Sylvia K. Plevritis, Sara Ahadi, Stephanie A. Nevins, Hayan Lee, Christian Martijn Schuerch, Sarah Black, Vishal Gautham Venkataraaman, Ed Esplin, Aaron Horning, Amir Bahmani, Xin Sun, Sanjay Jain 0006, James S. Hagood, Gloria Pryhuber, Peter V. Kharchenko, Bernd Bodenmiller, Todd Brusko, Michael Clare-Salzler, Harry Nick, Kevin Otto 0001, Clive Wasserfall, Marda Jorgensen, Maigan Brusko, Sergio Maffioletti, Richard M. Caprioli, Jeffrey M. Spraggins, Danielle Gutierrez, Nathan Heath Patterson, Elizabeth K. Neumann, Raymond Harris, Mark P. de Caestecker, Agnes B. Fogo, Raf Van de Plas, Ken Lau, Guo-Cheng Yuan, Qian Zhu, Ruben Dries, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, Isabel Goldaracena, Dong Hye Ye, Kristin E. Burnum-Johnson, Paul D. Piehowski, Charles Ansong, Ying Zhu, Tushar Desai, Jay Mulye, Peter Chou, Monica Nagendran, Sarah A. Teichmann, Benedict Paten, Robert F. Murphy, Jian Ma 0004, Vladimir Yu. Kiselev, Carl Kingsford, Allyson Ricarte, Maria Keays, Sushma Anand Akoju, Matthew Ruffalo, Margaret Vella, Chuck McCallum, Leonard E. Cross, Samuel H. Friedman, Randy W. Heiland, Bruce William Herr II, Paul Macklin, Ellen M. Quardokus, Lisel Record, James P. Sluka, Griffin M. Weber, Philip D. Blood, Alexander Ropelewski, William Shirey, Robin M. Scibek, Paula M. Mabee, W. Christopher Lenhardt, Kimberly Robasky, Stavros Michailidis, John C. Marioni, Andrew Butler, Tim Stuart, Eyal Fisher, Shila Ghazanfar, Gökcen Eraslan, Tommaso Biancalani, Eeshit D. Vaishnav, Pothur Srinivas, Aaron Pawlyk, Salvatore Sechi, Elizabeth L. Wilder, and James Anderson
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- 2019
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11. Ex‐vivo histopathologic examination of irrigated radiofrequency ablation utilizing half‐normal saline of the human heart
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Ajay Pillai, Valentina Robila, Vigneshwar Kasirajan, Kenneth A. Ellenbogen, and Jayanthi N. Koneru
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
12. Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data.
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Amar Koleti, Raymond Terryn, Vasileios Stathias, Caty Chung, Daniel J. Cooper, John Paul Turner, Dusica Vidovic, Michele Forlin, Tanya T. Kelley, Alessandro D'Urso, Bryce K. Allen, Denis Torre, Kathleen M. Jagodnik, Lily Wang, Sherry L. Jenkins, Christopher Mader, Wen Niu, Mehdi Fazel, Naim Al Mahi, Marcin Pilarczyk, Nicholas A. Clark, Behrouz Shamsaei, Jarek Meller, Juozas Vasiliauskas, John Reichard, Mario Medvedovic, Avi Ma'ayan, Ajay Pillai, and Stephan C. Schürer
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- 2018
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13. Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop.
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Kathleen M. Jagodnik, Simon Koplev, Sherry L. Jenkins, Lucila Ohno-Machado, Benedict Paten, Stephan C. Schürer, Michel Dumontier, Ruben Verborgh, Alex Bui, Peipei Ping, Neil J. McKenna, Ravi K. Madduri, Ajay Pillai, and Avi Ma'ayan
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- 2017
- Full Text
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14. Hemodynamic response and safety of vasodilator stress cardiovascular magnetic resonance in patients with permanent pacemakers or implantable cardioverter‐defibrillators
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Lauren Miller, Sergei Airapetov, Ajay Pillai, Gautham Kalahasty, Kenneth A. Ellenbogen, W. Gregory Hundley, and Cory R. Trankle
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Male ,Pacemaker, Artificial ,Magnetic Resonance Spectroscopy ,Heart Rate ,Vasodilator Agents ,Physiology (medical) ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,Magnetic Resonance Imaging ,Aged ,Defibrillators, Implantable ,Retrospective Studies - Abstract
Vasodilator stress cardiovascular magnetic resonance (CMR) is a powerful diagnostic modality, but data toward its use in patients with permanent pacemakers (PPMs) or implantable cardioverter-defibrillators (ICDs) is limited.Patients with ICDs (1% pacing) or PPMs who underwent regadenoson single photon emission computed tomography (SPECT) and all patients with ICDs or PPMs who underwent stress CMR were retrospectively identified. SPECT tests were analyzed for hemodynamic responses and new pacing requirements; CMR studies were examined for safety, device characteristics and programming, hemodynamic responses, and image quality. Changes from baseline were evaluated with the Related-Samples Wilcoxon Signed Rank Test. Of 67 patients (median age 65 [IQR 58-72] years, 31 [46%] female, 31 [46%] Black), 47 underwent SPECT and 20 CMR. With regadenoson SPECT, 89% of patients experienced tachycardic responses above resting heart rates (+19 [13-32] beats per minute, p .01). During stress CMR, 10 (50%) devices were asynchronously paced approximately 10 beats per minute above resting rates, and the remaining were temporarily deactivated. Those with asynchronous pacing had no changes in heart rates, whereas patients with deactivated devices had near uniform heart rate accelerations. Image quality was diagnostic in the majority of stress CMR sequences, with nonconditional ICDs contributing 40 of 57 (70%) of nondiagnostic segments.This data supports the safety of vasodilator stress CMR with promising diagnostic quality images in patients with CMR conditional ICDs and PPMs. Despite a near uniform tachycardic response to regadenoson in the SPECT environment, high rates of asynchronous pacing during vasodilator stress CMR did not result in competitive pacing or adverse arrhythmic events. Further studies are needed to validate these findings and confirm the diagnostic and prognostic performance of stress CMR in these individuals.
- Published
- 2022
15. PO-03-018 PERFORMANCE AND ECHOCARDIOGRAPHIC OUTCOMES OF LEFT POSTERIOR FASCICULAR CAPTURE DURING CONDUCTION SYSTEM PACING: A SINGLE CENTER EXPERIENCE
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W. Savindu Botheju, Jeffrey Kolominsky, Ramez Bodair, Royce Kim, Charles Nation, Pranav Mankad, Alexandre Raymond-Paquin, Jordana Kron, Gautham Kalahasty, Richard K. Shepard, Kenneth A. Ellenbogen, and Ajay Pillai
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
16. PO-03-009 3830 LEAD TIP POSITION ON COMPUTED TOMOGRAPHY AND ELECTROPHYSIOLOGIC OUTCOMES IN LEFT BUNDLE BRANCH AREA PACING
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Ajay Pillai, Rafae Shaikh, Jeffrey Kolominsky, Pranav Mankad, Jordana Kron, Jayanthi N. Koneru, Gautham Kalahasty, Richard K. Shepard, and Kenneth A. Ellenbogen
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
17. PO-03-026 ACUTE PROCEDURAL AND INTERMEDIATE-TERM LEAD PERFORMANCE OF LEFT BUNDLE BRANCH AREA PACING
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Ramez Bodair, Jeffrey Kolominsky, Charles Nation, Royce Kim, W. Savindu Botheju, Alexandre Raymond-Paquin, Pranav Mankad, Jordana Kron, Gautham Kalahasty, Richard K. Shepard, Jayanthi N. Koneru, Kenneth A. Ellenbogen, and Ajay Pillai
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
18. Pharos 2023:an integrated resource for the understudied human proteome
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Keith J Kelleher, Timothy K Sheils, Stephen L Mathias, Jeremy J Yang, Vincent T Metzger, Vishal B Siramshetty, Dac-Trung Nguyen, Lars Juhl Jensen, Dušica Vidović, Stephan C Schürer, Jayme Holmes, Karlie R Sharma, Ajay Pillai, Cristian G Bologa, Jeremy S Edwards, Ewy A Mathé, and Tudor I Oprea
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ONTOLOGY ,DATABASE ,DISCOVERY ,Genetics ,MAP ,VISUALIZATION - Abstract
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/), which curates and aggregates information, and Pharos (https://pharos.nih.gov/), a web interface for users to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.
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- 2023
19. Odontome- Revisted
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Neha Jain, Ajay Pillai, Amirthaa Varshini, Dhwani Kawadkar, Kriti Dubey, and Ajita Singh
- Abstract
Odontomas are benign odontogenic tumors subdivided morphologically into complex or compound odontomas. This paper describes the case of a complex odontoma in a 31-year-old male who complained of a painless swelling in right mandibular region which was diagnosed radiographically as complex odontome. Surgical enucleation of the lesion was done and sent for histopathological examination.
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- 2021
20. Autonomic Modulation for Treatment of Repolarization Alternans and Refractory Ventricular Electrical Storm
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Ajay Pillai, Jayanthi N. Koneru, Santosh K. Padala, and Kenneth A. Ellenbogen
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medicine.medical_specialty ,endocrine system diseases ,Case Report ,Ventricular tachycardia ,Sudden cardiac death ,Clinical Case ,Refractory ,Internal medicine ,medicine ,Repolarization ,cardiovascular diseases ,treatment ,business.industry ,electrophysiology ,ventricular fibrillation ,medicine.disease ,ICD, implantable cardioverter-defibrillator ,eye diseases ,Electrophysiology ,Increased risk ,Ventricular fibrillation ,cardiovascular system ,Cardiology ,ECG, electrocardiogram ,ventricular tachycardia ,Autonomic modulation ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology - Abstract
Macroscopic T-wave alternans (TWA) is a rare finding on surface electrocardiogram and has been associated with an increased risk of impending sudden cardiac death. We highlight a case of macroscopic TWA in a patient with markedly prolonged QTc interval preceding ventricular electrical storm, which was refractory to medical management. Autonomic modulation of the stellate ganglion resulted in improvement in both TWA and QTc interval. (Level of Difficulty: Advanced.), Central Illustration
- Published
- 2021
21. PO-02-079 SAFETY AND FEASIBILITY OF DEVICE EXTRACTION OF THE HIS 3830 SELECTSECURE© LEAD
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Jeffrey Kolominsky, Naga Vaishnavi Gadela, Rafae Shaikh, Jordana Kron, Kenneth A. Ellenbogen, Ajay Pillai, Richard K. Shepard, and Jayanthi N. Koneru
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
22. PO-03-044 EFFECT OF V1 PACED MORPHOLOGY DURING IMPLANTATION OF LEFT BUNDLE BRANCH AREA PACEMAKERS ON ECHOCARDIOGRAPHIC OUTCOMES
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Jeffrey Kolominsky, Royce Kim, W. Savindu Botheju, Charles Nation, Ramez Bodair, Richard K. Shepard, Gautham Kalahasty, Jordana Kron, Alexandre Raymond-Paquin, Jayanthi N. Koneru, Pranav Mankad, Kenneth A. Ellenbogen, and Ajay Pillai
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
23. PO-03-019 ECHOCARDIOGRAPHIC OUTCOMES OF HIS BUNDLE AND LEFT BUNDLE BRANCH AREA PACING: A SINGLE CENTER EXPERIENCE
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Jeffrey Kolominsky, Royce Kim, W. Savindu Botheju, Charles Nation, Ramez Bodair, Alexandre Raymond-Paquin, Jordana Kron, Jayanthi N. Koneru, Richard K. Shepard, Gautham Kalahasty, Pranav Mankad, Kenneth A. Ellenbogen, and Ajay Pillai
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
24. A Tale of 2 Blocks
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Santosh K. Padala, Ajay Pillai, and Kenneth A. Ellenbogen
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medicine.medical_specialty ,business.industry ,Physiology (medical) ,Family medicine ,Atrial Fibrillation ,MEDLINE ,Humans ,Medicine ,Female ,Middle Aged ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
25. An Unusual Complication of Transseptal Puncture
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Santosh K. Padala, Jayanthi N. Koneru, Kenneth A. Ellenbogen, and Ajay Pillai
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0301 basic medicine ,medicine.medical_specialty ,IAS, interatrial septum ,complication ,030105 genetics & heredity ,Pericardial effusion ,SVC, superior vena cava ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,Cardiac tamponade ,medicine ,Diseases of the circulatory (Cardiovascular) system ,atrial fibrillation ,cardiovascular diseases ,Aorta ,business.industry ,Atrial fibrillation ,medicine.disease ,electrophysiology ,Atrial septum ,pericardial effusion ,medicine.anatomical_structure ,RC666-701 ,Cardiology ,cardiovascular system ,Mini-Focus Issue: Procedural Complications: Part 2 ,Case Report: Clinical Case ,Cardiology and Cardiovascular Medicine ,Complication ,business ,030217 neurology & neurosurgery ,Interatrial septum - Abstract
The interatrial septum is a structure with complex embryological development. The true atrial septum is a circumscribed structure, and transgression outside of this area during transseptal puncture may result in entry into the extracardiac space or aorta that may result in a pericardial effusion or cardiac tamponade. (Level of Difficulty: Intermediate.), Graphical abstract
- Published
- 2021
26. Left bundle branch area pacing in patients with atrioventricular conduction disease: A prospective multicenter study
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Alexandre Raymond-Paquin, Atul Verma, Jeffrey Kolominsky, Paula Sanchez-Somonte, Enes Elvin Gul, Ajay Pillai, Jordana Kron, Richard Shepard, Gautham Kalahasty, Bernice Tsang, Yaariv Khaykin, Alfredo Pantano, Jayanthi N. Koneru, and Kenneth A. Ellenbogen
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Aged, 80 and over ,Bundle of His ,Electrocardiography ,Treatment Outcome ,Physiology (medical) ,Bundle-Branch Block ,Cardiac Pacing, Artificial ,Humans ,Prospective Studies ,Middle Aged ,Cardiology and Cardiovascular Medicine ,Atrioventricular Block ,Aged - Abstract
The reported success rate of His-bundle pacing (HBP) in patients with infranodal atrioventricular (AV) conduction disease is only 52%-76%. The success rate of left bundle branch area pacing (LBBAP) in this cohort is not well studied.The purpose of this study was to evaluate the feasibility, safety, and electrophysiological characteristics of LBBAP in patients with AV conduction disease.Patients with AV conduction disease referred for pacemaker implantation at 2 centers between February 2019 and June 2021 were considered for LBBAP. Baseline demographic characteristics, procedural success rates, electrophysiological parameters, and complications were assessed.LBBAP was successful in 340 of 364 patients (93%). Mean age was 72 ± 13 years, and mean follow-up was 331 ± 244 days. Pacing indications were Mobitz I in 27 patients (7%), Mobitz II or 2:1 AV block or high-grade AV block in 94 patients (26%), complete heart block in 199 patients (55%), and sick sinus syndrome with isolated bundle branch block in 44 patients (12%). Left bundle branch block and right bundle branch block were present in 57 patients (16%) and 140 patients (38%), respectively. Procedural success rates did not differ between indications (92.6%, 93.6%, 92.9%, and 95%, respectively) or between patients with narrow (120 ms) vs wide QRS (≥120 ms). Mean LBBAP threshold was 0.77 ± 0.34 V at 0.4 ms at implant and remained stable during follow-up. There were 4 (1.2%) acute LBBAP lead dislodgments.LBBAP is safe and feasible with high success rates for patients with AV conduction disease. In contrast to HBP, LBBAP success rates remain high over the entire spectrum of AV conduction disease, and lead parameters remain stable during follow-up.
- Published
- 2022
27. Eosinophilic Granulomatosis With Polyangiitis Presenting as an Acute Coronary Syndrome
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Jaideep Patel, Jonathan Potfay, DO Zackary Tushak, Aaron Schatz, Ajay Pillai, and Jeffrey Kolominsky
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0301 basic medicine ,ANCA, antineutrophilic cytoplasmic antibody ,ESR - Erythrocyte sedimentation rate ,medicine.medical_specialty ,Acute coronary syndrome ,LMCA, left main coronary artery ,Case Report ,030105 genetics & heredity ,Uncommon disorder ,vasculitis ,acute coronary syndrome ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Clinical Case ,immune system diseases ,Internal medicine ,hemic and lymphatic diseases ,Eosinophilic ,CA, coronary angiograph ,Medicine ,Eosinophilia ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,DES, drug-eluting stent ,premature coronary artery disease ,EGPA, eosinophilic granulomatosis with polyangiitis ,ESR, erythrocyte sedimentation rate ,LCx, left circumflex artery ,R-PLB, right posterior-lateral branch ,business.industry ,CABG, coronary artery bypass graft ,medicine.disease ,ischemic heart disease ,EGPA ,OM1, obtuse marginal artery ,respiratory tract diseases ,LAD, left anterior descending artery ,RC666-701 ,Cardiology ,CRP, C-reactive protein ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Vasculitis ,Granulomatosis with polyangiitis ,eosinophilia ,030217 neurology & neurosurgery ,RCA, right coronary artery - Abstract
Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss Syndrome, is an uncommon disorder that carries a high mortality when coronary artery disease develops. Early recognition and treatment is crucial. We highlight an unusual presentation of acute coronary syndrome not associated with atherosclerotic coronary disease. (Level of Difficulty: Intermediate.), Graphical abstract, Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss Syndrome, is an uncommon disorder that carries a high mortality when coronary…
- Published
- 2020
28. Coronavirus disease 2019 and cardiovascular diseases: collateral damage?
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Barbara Lawson and Ajay Pillai
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medicine.medical_specialty ,Myocarditis ,Viral Myocarditis ,COVID-19 Vaccines ,medicine.medical_treatment ,Sepsis ,Pericarditis ,coronavirus disease 2019 ,cardiovascular disease ,Internal medicine ,medicine ,Humans ,myocardial injury ,Myocardial infarction ,Mechanical ventilation ,business.industry ,SARS-CoV-2 ,COVID-19 ,Atrial fibrillation ,medicine.disease ,CARDIOVASCULAR ANESTHESIA: Edited by Nirvik Pal ,Vaccination ,Anesthesiology and Pain Medicine ,Cardiovascular Diseases ,Cardiology ,business - Abstract
PURPOSE OF REVIEW: Cardiovascular involvement in coronavirus disease 2019 (CoVID-19) is relatively common and portends an increased risk of morbidity and mortality. Manifestations of myocardial injury may exhibit significant overlap and result in diagnostic uncertainty. This review will summarize recent literature around cardiovascular complications of CoVID-19. RECENT FINDINGS: Venous thromboembolism, atrial fibrillation, and type II myocardial infarction are observed commonly in CoVID-19, while severe acute respiratory syndrome coronavirus 2 viral myocarditis remains quite rare. Although infrequent, CoVID-19 vaccination has been associated with myocarditis and pericarditis in young individuals. SUMMARY: Various forms of CoVID-19-related myocardial injury have been associated with increased utilization of mechanical ventilation, hemodynamic deterioration, and mortality. Manifestations of myocardial injury in CoVID-19 are varied, but share common drivers of illness including sequelae of sepsis, immune-mediated factors, and a prothrombotic state. Understanding the forms of myocardial injury in CoVID-19 may aid in rapid diagnosis and treatment.
- Published
- 2021
29. Atrioventricular junction ablation in patients with conduction system pacing leads: A comparison of His-bundle vs left bundle branch area pacing leads
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Ajay Pillai, Jeffrey Kolominsky, Jayanthi N. Koneru, Jordana Kron, Richard K. Shepard, Gautham Kalahasty, Weijian Huang, Atul Verma, and Kenneth A. Ellenbogen
- Subjects
Bundle of His ,Electrocardiography ,Treatment Outcome ,Cardiac Conduction System Disease ,Heart Conduction System ,Physiology (medical) ,Atrial Fibrillation ,Cardiac Pacing, Artificial ,Humans ,Cardiology and Cardiovascular Medicine - Abstract
Single-center studies have shown feasibility of conduction system pacing (CSP) via His-bundle pacing (HBP) or left bundle branch area pacing (LBBAP) in atrial fibrillation (AF) patients undergoing atrioventricular junction ablation (AVJA).The purpose of this study was to compare outcomes in patients with HBP and LBBAP leads undergoing AVJA.Consecutive patients with CSP leads referred for AVJA between October 2014 and May 2021 were included. Pacing lead characteristics, procedural characteristics, complications, and long-term outcomes were assessed.One hundred five AVJA procedures (55 HBP, 50 LBBAP) were performed in 98 patients (48 HBP, 50 LBBAP). The acute success rate of the AVJA procedure was 94% vs 100% (P = .11) in HBP vs LBBAP groups. Seven (14%) redo AVJA procedures were required in the HBP group. Mean procedural time (44 ± 24 min vs 34 ± 16 min; P = .02) and mean fluoroscopy time (16 ± 18 min vs 7 ± 6 min; P.001) were significantly longer in the HBP vs LBBAP group. An acute rise in threshold was noted in 8 cases (14.5%), and 4 (8%) developed exit block after AVJA in HBP patients. Chronic HBP threshold ≥2.5 V was seen in 23 patients (48%), and 4 (8%) HBP leads were deactivated. CSP preserved ejection fraction (EF) in the overall cohort (N = 70; 53% ± 10% vs 55% ± 10%; P = .09) and significantly improved in those with reduced EF50% at baseline (N = 16; 37% ± 7.6% vs 46% ± 13%; P = .02).AVJA in the presence of an LBBAP lead is associated with a higher success rate and fewer acute and chronic lead-related complications. CSP with either HBP or LBBAP preserves left ventricular systolic function in patients with refractory atrial fibrillation post AVJA.
- Published
- 2021
30. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
- Author
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William J. Greenleaf, Sarah A. Teichmann, Margaret Vella, Ajay Pillai, Aviv Regev, Ananda L. Roy, Kristin E. Burnum-Johnson, Cole Trapnell, Yiing Lin, Marda Jorgensen, Gloria S. Pryhuber, Leslie Gaffney, Ken S. Lau, Kimberly Robasky, Jeffrey M. Spraggins, Chuck McCallum, Stavros Michailidis, Randy Heiland, Orit Rozenblatt-Rosen, Allyson Ricarte, Xin bSun, Kevin J. Otto, Amir Bahmani, Zorina S. Galis, James S. Hagood, Monica Nagendran, Gökcen Eraslan, Robin M. Scibek, Jocelyn Y. Kishi, Jay Mulye, Maria Keays, Griffin M. Weber, Caltech-UW Tmc, Charles Ansong, Nicholas A. Nystrom, Vishal G. Venkataraaman, Vladimir Yu. Kiselev, Ucsd Tmc, Ellen M. Quardokus, Tushar bDesai, Bruce Herr, Engagement Component, James E. Anderson, Shin Lin, Lisel Record, Peter V. Kharchenko, Robert F. dMurphy, Stanford-WashU Tmc, Yu Wang, Jian Ma, Sergio Maffioletti, Sarah Black, Matthew Ruffalo, Salvatore Sechi, John C. Marioni, Ziv Bar-Joseph, Richard M. Caprioli, Stanford Ttd, Garry P. Nolan, Marishka Brown, Elizabeth L. Wilder, Maigan A. Brusko, Peter Chou, Tommaso Biancalani, Christian Martijn Schuerch, Julia Laskin, Richard Conroy, Jonathan C. Silverstein, Paula M. Mabee, Dena Procaccini, Pehr B. Harbury, Michael Snyder, Pothur Srinivas, Jennifer Rood, Dana Jackson, Sanjay Jain, Katy Börner, Visualization HuBMAP Integration, William E. Shirey, Sinem K. Saka, James P. Sluka, Agnes B. Fogo, Isabel Goldaracena, Sushma A. Akoju, Raymond C. Harris, Rahul Satija, Sylvia K. Plevritis, Tim Stuart, Shila Ghazanfar, Peng Yin, Harvard Ttd, Aaron M. Horning, Ed Esplin, Amanda Posgai, Michael J. Clare-Salzler, Raf Van de Plas, Aaron Pawlyk, Guo-Cheng Yuan, Benedict aten, DongHye Ye, Hayan Lee, Eyal Fisher, Jay Shendure, Long Cai, Danielle cGutierrez, Carl Kingsford, Ruben Dries, Sara Ahadi, Paul D. Piehowski, Bernd bBodenmiller, Purdue Ttd, Stephanie A. Nevins, Philip D. Blood, Andrew Butler, W. Christopher Lenhardt, Ying Zhu, Alexander J. Ropelewski, Harry S. Nick, Nathan Heath Patterson, Elizabeth K. Neumann, Anna Hupalowska, Samuel H. Friedman, Clive hWasserfall, Qian Zhu, Mark P. deCaestecker, Leonard E. Cross, Mark A. Atkinson, Paul Macklin, Todd M. Brusko, Eeshit Dhaval Vaishnav, Nils Gehlenborg, and Kun Zhang
- Subjects
Male ,Models, Anatomic ,Aging ,Biomedical Research ,media_common.quotation_subject ,International Cooperation ,Art history ,Technology development ,Molecular resolution ,03 medical and health sciences ,0302 clinical medicine ,Atlases as Topic ,Computational platforms and environments ,Research community ,Common fund ,Humans ,Molecular Biology ,030304 developmental biology ,media_common ,0303 health sciences ,Shared vision ,Multidisciplinary ,Spatial mapping ,Art ,Genomics ,United States ,3. Good health ,Cellular resolution ,National Institutes of Health (U.S.) ,Health ,Organ Specificity ,Perspective ,Female ,Single-Cell Analysis ,030217 neurology & neurosurgery - Abstract
Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible three-dimensional molecular and cellular atlas of the human body, in health and under various disease conditions., HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.
- Published
- 2019
31. PO-708-06 FEASIBILITY OF RIGHT SIDED LEFT BUNDLE BRANCH AREA PACEMAKER INSERTION: A SINGLE CENTER PROSPECTIVE STUDY
- Author
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Jeffrey Kolominsky, Ajay Pillai, Todd L. Teigeler, Alexandre Raymond-Paquin, Richard K. Shepard, Gautham Kalahasty, Jordana Kron, Jayanthi N. Koneru, Kenneth A. Ellenbogen, and Santosh K. Padala
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2022
32. B-AB14-02 INTERMEDIATE TERM PERFORMANCE AND SAFETY OF LEFT BUNDLE BRANCH AREA CONDUCTION SYSTEM PACING LEADS: A MULTICENTER PROSPECTIVE STUDY
- Author
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Jeffrey Kolominsky, Alfredo Pantano, Yaariv Khaykin, Paula Sanchez Somonte, Gautham Kalahasty, Atul Verma, Richard K. Shepard, Bernice Tsang, Enes Elvin Gul, Jayanthi N. Koneru, Ajay Pillai, Santosh K. Padala, Kenneth A. Ellenbogen, and Jordana Kron
- Subjects
Intermediate term ,medicine.medical_specialty ,business.industry ,Physiology (medical) ,Internal medicine ,Left bundle branch ,medicine ,Cardiology ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,Prospective cohort study ,business - Published
- 2021
33. B-PO04-122 EX-VIVO HISTOPATHOLOGIC EXAMINATION AND IN-VIVO MRI ANALYSIS OF IRRIGATED RADIOFREQUENCY ABLATION UTILIZING HALF-NORMAL SALINE OF HUMAN HEART
- Author
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Austin Wiles, Kenneth A. Ellenbogen, Vigneshwar Kasirajan, Santosh K. Padala, John R. Onufer, Valentina Robila, Jayanthi N. Koneru, and Ajay Pillai
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Radiofrequency ablation ,medicine.medical_treatment ,Human heart ,law.invention ,In vivo ,law ,Physiology (medical) ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Saline ,Ex vivo - Published
- 2021
34. B-PO03-045 LEFT BUNDLE BRANCH AREA PACING IN PATIENTS WITH AV NODAL AND INFRA NODAL DISEASE: A MULTICENTER PROSPECTIVE STUDY
- Author
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Enes Elvin Gul, Jordana Kron, Gautham Kalahasty, Jeffrey Kolominsky, Atul Verma, Bernice Tsang, Santosh K. Padala, Jayanthi N. Koneru, Ajay Pillai, Alfredo Pantano, Paula Sanchez Somonte, Richard K. Shepard, Yaariv Khaykin, and Kenneth A. Ellenbogen
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,Left bundle branch ,medicine ,In patient ,Radiology ,Cardiology and Cardiovascular Medicine ,Prospective cohort study ,NODAL ,business ,Nodal disease - Published
- 2021
35. In spite of successful curative surgery for buccal mucosa carcinoma the health-related quality-of-life continues to remain poor
- Author
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Yogesh Sharma, Ajay Pillai, Shreshth Sharma, Neha Jain, Renu Singh, and Suhani Ghai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Swallowing ,Quality of life ,Internal medicine ,Surveys and Questionnaires ,Carcinoma ,Medicine ,Humans ,Stage (cooking) ,030223 otorhinolaryngology ,Aged ,business.industry ,Mouth Mucosa ,030206 dentistry ,Middle Aged ,medicine.disease ,humanities ,Radiation therapy ,Mood ,Otorhinolaryngology ,Oral and maxillofacial surgery ,Carcinoma, Squamous Cell ,Quality of Life ,Anxiety ,Surgery ,Female ,Mouth Neoplasms ,Oral Surgery ,medicine.symptom ,business - Abstract
In early stage buccal mucosa carcinoma, in spite of successful curative surgery, the health-related quality-of-life (HRQoL) may not improve. We aimed to study HRQoL in these patients who had undergone successful curative surgery and determined factors that influence the HRQoL. Subjects, aged 18–70 years, who had undergone successful curative surgery for stage I and II buccal mucosa cancer, were assessed for HRQoL using the University of Washington Quality of Life Questionnaire and factors affecting HRQoL were determined. Their scores were compared with normative reference scores. 54 patients (stages I 54%, II 46%) aged 44 ± 11 years (87% males) were studied. They had undergone curative surgery a median of 8.5 (IQR 4–13.5) months ago. Their mean global HRQoL score was 77 ± 30, with significantly poorer scores compared to reference in domains of appearance, activity, swallowing, chewing, speech, shoulder, saliva, mood and anxiety. Anxiety, activity, and chewing were considered the most important domains by the patients. Among the factors influencing HRQoL, duration since surgery was the most important factor, and patients with recent surgery had worse performance in chewing, saliva and mood. Patients with stage II had worse performance in shoulder and anxiety compared to stage I. Post-operative radiotherapy worsened swallowing and shoulder function. In spite of successful curative surgery for buccal mucosa carcinoma, the HRQoL continues to remain sub-optimal with poor scores in most of the domains. These domains must be focused on with appropriate measures in order to improve overall HRQoL in patients after successful curative surgery.
- Published
- 2020
36. STRESS VASODILATOR EFFECTS ON PATIENTS WITH CARDIAC IMPLANTABLE ELECTRONIC DEVICES AND SAFETY IN THE MAGNETIC RESONANCE ENVIRONMENT
- Author
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Lauren Miller, Sergei Airapetov, Ajay Pillai, Gautham Kalahasty, and Cory Trankle
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
37. Design Optimisation Of Spur Gear Using Genetic Algorithm
- Author
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Ajay Pillai, K, primary, Ray, Aritra Guha, additional, Kaul, Shivam, additional, and Babu T, Narendiranath, additional
- Published
- 2021
- Full Text
- View/download PDF
38. Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross
- Author
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Jacquin C. Niles, Ajay Pillai, Abdullah A. B. Bokhari, Suresh M. Ganesan, Armiyaw S. Nasamu, Sanjay A. Desai, Jeanine Gezelle, Gagandeep Singh Saggu, Anna K. Crater, and Ankit Gupta
- Subjects
Plasmodium ,Erythrocytes ,Protozoan Proteins ,Ion Channels ,Animal Cells ,Red Blood Cells ,Medicine and Health Sciences ,Malaria, Falciparum ,Biology (General) ,Protozoans ,0303 health sciences ,Gene knockdown ,biology ,Cell Death ,030302 biochemistry & molecular biology ,Malarial Parasites ,Eukaryota ,Phenotype ,3. Good health ,Cell biology ,Cell Processes ,Physical Sciences ,symbols ,Cellular Types ,Research Article ,QH301-705.5 ,Transgene ,Immunology ,Plasmodium falciparum ,Materials Science ,Material Properties ,Transfection ,Research and Analysis Methods ,Microbiology ,Permeability ,03 medical and health sciences ,symbols.namesake ,Genetic linkage ,Virology ,Parasite Groups ,Genetics ,Parasitic Diseases ,Epigenetics ,Molecular Biology Techniques ,Gene ,Molecular Biology ,Crosses, Genetic ,030304 developmental biology ,Blood Cells ,Cytolysis ,Organisms ,Biology and Life Sciences ,Biological Transport ,Nutrients ,Cell Biology ,RC581-607 ,biology.organism_classification ,Parasitic Protozoans ,Nutrition Assessment ,Mendelian inheritance ,Parasitology ,Immunologic diseases. Allergy ,Cell Adhesion Molecules ,Apicomplexa ,Cloning - Abstract
Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte membrane to obtain essential nutrients from the bloodstream. This conserved channel, known as the plasmodial surface anion channel (PSAC), has been linked to parasite clag3 genes in P. falciparum, but epigenetic switching between the two copies of this gene hinders clear understanding of how the encoded protein determines PSAC activity. Here, we used linkage analysis in a P. falciparum cross where one parent carries a single clag3 gene to overcome the effects of switching and confirm a primary role of the clag3 product with high confidence. Despite Mendelian inheritance, CLAG3 conditional knockdown revealed remarkably preserved nutrient and solute uptake. Even more surprisingly, transport remained sensitive to a CLAG3 isoform-specific inhibitor despite quantitative knockdown, indicating that low doses of the CLAG3 transgene are sufficient to confer block. We then produced a complete CLAG3 knockout line and found it exhibits an incomplete loss of transport activity, in contrast to rhoph2 and rhoph3, two PSAC-associated genes that cannot be disrupted because nutrient uptake is abolished in their absence. Although the CLAG3 knockout did not incur a fitness cost under standard nutrient-rich culture conditions, this parasite could not be propagated in a modified medium that more closely resembles human plasma. These studies implicate oligomerization of CLAG paralogs encoded by various chromosomes in channel formation. They also reveal that CLAG3 is dispensable under standard in vitro conditions but required for propagation under physiological conditions., Author summary Malaria, a globally important infectious disease, is caused by parasites that invade and grow in circulating red blood cells to avoid host immune attack. Infected red blood cells have increased uptake of diverse nutrients, fueling parasite growth; this uptake is mediated by an ion channel that transports essential nutrients across the red blood cell membrane. Three proteins made by the parasite have been linked to this channel, but how they increase uptake is unknown. Here, we used mapping in a genetic cross of two strains of the virulent human malaria parasite to confirm a primary role of one protein known as CLAG3. We then used gene editing to produce a parasite that has reduced CLAG3 levels when a stabilizing chemical is removed; surprisingly, solute transport was minimally changed despite a 90% reduction in CLAG3. Gene editing was also used to make a parasite without any CLAG3. This knockout parasite had reduced nutrient uptake, but it still grew normally in media with high nutrient levels; it was unable to grow when nutrient levels were lowered to levels like those in the human bloodstream. The complex effects of channel inhibitors on these genetically modified parasites suggests that CLAG3 and the two other proteins interact with each other to form large protein clusters in the red blood cell membrane; these clusters may form the nutrient uptake pore. Our studies indicate that CLAG3 is required for parasite survival and growth in the bloodstream and that the channel it produces can be targeted to make new antimalarial drugs.
- Published
- 2020
39. Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding
- Author
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Ha Won Kim, Matthew Crowe, Weiqin Chen, Orishebawo Popoola, Brian K. Stansfield, Tyler W. Benson, Yan Gao, Yao Liang Tang, David W. Stepp, James G. Wilson, Tapan K. Chatterjee, Vladimir Y. Bogdanov, Neal L. Weintraub, Julia E. Brittain, Krystal Archer, Charlotte Greenway, James D. Mintz, Daniel S. Weintraub, Joel Joseph, Ajay Pillai, and Nicole K.H. Yiew
- Subjects
Male ,0301 basic medicine ,Chemokine ,medicine.medical_specialty ,medicine.medical_treatment ,DARC ,Adipose tissue ,Receptors, Cell Surface ,Inflammation ,030204 cardiovascular system & hematology ,Diet, High-Fat ,Weight Gain ,Biochemistry ,Article ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Internal medicine ,Glucose Intolerance ,medicine ,Animals ,Obesity ,Receptor ,Molecular Biology ,Adiposity ,Mice, Knockout ,biology ,High fat diet ,Leptin ,Insulin ,Feeding Behavior ,medicine.disease ,Mice, Inbred C57BL ,Phenotype ,030104 developmental biology ,Adipose Tissue ,Knockout mouse ,biology.protein ,Female ,medicine.symptom ,Duffy Blood-Group System ,Gene Deletion - Abstract
Objective Inflammation in adipose tissues in obesity promotes insulin resistance and metabolic disease. The Duffy antigen receptor for chemokines (DARC) is a promiscuous non-signaling receptor expressed on erythrocytes and other cell types that modulates tissue inflammation by binding chemokines such as monocyte chemoattractant protein-1 (MCP-1) and by acting as a chemokine reservoir. DARC allelic variants are common in humans, but the role of DARC in modulating obesity-related metabolic disease is unknown. Methods We examined body weight gain, tissue adiposity, metabolic parameters and inflammatory marker expression in wild-type and DARC knockout mice fed a chow diet (CD) and high fat diet (HFD). Results Compared to wild-type mice, HFD-fed DARC knockout mice developed glucose intolerance and insulin resistance independent of increases in body weight or adiposity. Interestingly, insulin sensitivity was also diminished in lean male DARC knockout mice fed a chow diet. Insulin production was not reduced by DARC gene deletion, and plasma leptin levels were similar in HFD fed wild-type and DARC knockout mice. MCP-1 levels in plasma rose significantly in the HFD fed wild-type mice, but not in the DARC knockout mice. Conversely, adipose tissue MCP-1 levels were higher, and more macrophage crown-like structures were detected, in the HFD fed DARC knockout mice as compared with the wild-type mice, consistent with augmented adipose tissue inflammation that is not accurately reflected by plasma levels of DARC-bound MCP-1 in these mice. Conclusions These findings suggest that DARC regulates metabolic function and adipose tissue inflammation, which may impact obesity-related disease in ethnic populations with high frequencies of DARC allelic variants.
- Published
- 2018
40. Use of 3-D printing technologies in craniomaxillofacial surgery: a review
- Author
-
Ajay Pillai, Neha Jain, Suhani Ghai, Mrinal Satpathy, and Yogesh Sharma
- Subjects
Rapid prototyping ,medicine.medical_treatment ,Operative Time ,Orthognathic surgery ,3 d printing ,Prosthesis Design ,03 medical and health sciences ,0302 clinical medicine ,Full recovery ,medicine ,Humans ,Orthodontics ,Orthognathic Surgical Procedures ,business.industry ,Craniomaxillofacial surgery ,Prostheses and Implants ,030206 dentistry ,Patient data ,Radiation Exposure ,Plastic Surgery Procedures ,Splints ,Surgery, Computer-Assisted ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Printing, Three-Dimensional ,Oral and maxillofacial surgery ,Computer-Aided Design ,Surgery ,Oral Surgery ,business - Abstract
Three-dimensional (3-D) printing is a method of manufacturing in which materials like plastic or metal are deposited onto one another in layers to produce a 3-D object. Because of the complex anatomy of craniomaxillofacial structures, full recovery of craniomaxillofacial tissues from trauma, surgeries, or congenital malformations is extremely challenging. 3-D printing of scaffolds, tissue analogs, and organs has been proposed as an exciting alternative to address some of these key challenges in craniomaxillofacial surgery. There are four broad types of 3-D printing surgical applications that can be used in craniomaxillofacial surgery: contour models (positive-space models to allow preapplication of hardware before surgery), guides (negative-space models of actual patient data to guide cutting and drilling), splints (negative-space models of virtual postoperative positions to guide final alignment), and implants (negative-space 3-D printed implantable materials or 3-D printed molds into which nonprintable materials are poured). 3-D printing technology is being successfully used for surgeries for head and neck malignancies, mandibular reconstruction, orthognathic surgeries, for mandibulectomies after osteoradionecrosis, orbital floor fracture surgeries, nasal reconstruction, and cranioplasties. The excitement behind 3-D printing continues to increase and hopefully will drive improvements in the technology and its surgical applications, especially in craniomaxillofacial region. This present review sets out to explore use of 3-D printing technologies in craniomaxillofacial surgery.
- Published
- 2018
41. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
- Author
-
Nicholas A. Clark, Marc R. Birtwistle, Jennifer E. Van Eyk, Moshe C. Silverstein, Caitlin E. Mills, Mario Niepel, Marcin Pilarczyk, Alexander Lachmann, Elizabeth H. Williams, Simon Koplev, Nathanael S. Gray, Uzma Hussain, Albert Lee, Ajay Pillai, Edward He, Mark A. Dane, Evren U. Azeloglu, Dusica Vidovic, Jeannette Osterloh, Maria G. Banuelos, Maxim V. Kuleshov, Rick J. Koch, Stephan C. Schürer, Karen Sachs, Damir Sudar, Divya Ramamoorthy, Dhruv Sareen, Shana White, Heidi S. Feiler, Siva Sivaganesan, Kathleen M. Jagodnik, Clive N. Svendsen, Mohammad Fallahi-Sichani, Miriam Adam, Jaroslaw Meller, Todd R. Golub, Ravi Iyengar, Jennifer Stocksdale, Amar Koleti, David Wrobel, Sherry L. Jenkins, Jacob D. Jaffe, Alexandra B Keenan, Renan Escalante-Chong, Daniel J. Cooper, Loren Ornelas, Joe W. Gray, Alexander LeNail, Ritchie Ho, Alyssa Coye, Avi Ma'ayan, Steve Finkbiener, Lixia Zhang, Andrea Matlock, Eric A. Sobie, Vidya Venkatraman, Anders B. Dohlman, Jeffrey D. Rothstein, Michele Forlin, Jonathan Z. Li, Rebecca Smith, Naim Al Mahi, Kaylyn Devlin, Caty Chung, Marc Hafner, Malvina Papanastasiou, Wen Niu, Michal Kouril, Ryan G. Lim, Yan Ren, Julia A. Kaye, Malcolm Casale, Jie Wu, Mario Medvedovic, Jeremy L. Muhlich, Victoria Dardov, Jouzas Vasiliauskas, Kelly Haston, Caroline E. Shamu, Raymond Terryn, John F. Reichard, Michel Nederlof, David Kilburn, Leslie M. Thompson, Jia-Ren Lin, Vasileios Stathias, Zichen Wang, Behrouz Shamsaei, James E. Korkola, Pamela Milani, Berhan Mandefro, Terri G. Thompson, Laura M. Heiser, Gavin Daigle, Denis Torre, Ron Margolis, Aravind Subramanian, Elmar Bucher, Sean D. Erickson, Ernest Fraenkel, Jaslin Kalra, Mark A. LaBarge, Gordon B. Mills, Peter K. Sorger, Sean M. Gross, Leslie Derr, and Mehdi Fazel
- Subjects
0301 basic medicine ,Histology ,National Health Programs ,Computer science ,Systems biology ,Information Storage and Retrieval ,Cataloging ,Transcript profiling ,Computational biology ,Imaging data ,Article ,Pathology and Forensic Medicine ,World Wide Web ,03 medical and health sciences ,Human disease ,Common fund ,System level ,Humans ,Gene Library ,Gene Expression Profiling ,Systems Biology ,Computational Biology ,Cell Biology ,United States ,030104 developmental biology ,National Institutes of Health (U.S.) ,Transcriptome ,Databases, Chemical ,Systems pharmacology - Abstract
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.
- Published
- 2018
42. Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data
- Author
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Caty Chung, Nicholas A. Clark, Michele Forlin, John Paul Turner, Christopher C. Mader, Mehdi Fazel, Sherry L. Jenkins, Amar Koleti, Naim Al Mahi, John F. Reichard, Tanya T. Kelley, Alessandro D'Urso, Kathleen M. Jagodnik, Dusica Vidovic, Mario Medvedovic, Marcin Pilarczyk, Vasileios Stathias, Behrouz Shamsaei, Lily Wang, Wen Niu, Avi Ma'ayan, Stephan C. Schürer, Daniel J. Cooper, Denis Torre, Bryce K. Allen, Raymond Terryn, Juozas Vasiliauskas, Jarek Meller, and Ajay Pillai
- Subjects
Epigenomics ,Proteomics ,0301 basic medicine ,Databases, Factual ,Test data generation ,Big data ,Cataloging ,Biology ,Bioinformatics ,User-Computer Interface ,03 medical and health sciences ,0302 clinical medicine ,Software ,Databases, Genetic ,Genetics ,Database Issue ,Humans ,Data Curation ,Metadata ,Information retrieval ,Data curation ,business.industry ,Systems Biology ,Computational Biology ,Cell Biology ,030104 developmental biology ,Data analysis ,User interface ,business ,030217 neurology & neurosurgery - Abstract
The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analytics tools to improve our understanding of human diseases at the systems level. In contrast to other large-scale data generation efforts, LINCS Data and Signature Generation Centers (DSGCs) employ a wide range of assay technologies cataloging diverse cellular responses. Integration of, and unified access to LINCS data has therefore been particularly challenging. The Big Data to Knowledge (BD2K) LINCS Data Coordination and Integration Center (DCIC) has developed data standards specifications, data processing pipelines, and a suite of end-user software tools to integrate and annotate LINCS-generated data, to make LINCS signatures searchable and usable for different types of users. Here, we describe the LINCS Data Portal (LDP) (http://lincsportal.ccs.miami.edu/), a unified web interface to access datasets generated by the LINCS DSGCs, and its underlying database, LINCS Data Registry (LDR). LINCS data served on the LDP contains extensive metadata and curated annotations. We highlight the features of the LDP user interface that is designed to enable search, browsing, exploration, download and analysis of LINCS data and related curated content.
- Published
- 2017
43. B-AB09-03 INTERMEDIATE ECHOCARDIOGRAPHIC OUTCOMES OF CONDUCTION SYSTEM PACING
- Author
-
Gautham Kalahasty, Kenneth A. Ellenbogen, Atul Verma, Jayanthi N. Koneru, Richard K. Shepard, Ajay Pillai, Chau N. Vo, Santosh K. Padala, Jeffrey Kolominsky, Todd L. Teigeler, and Jordana Kron
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,Internal medicine ,medicine ,Cardiology ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
44. B-PO03-044 SAFETY AND FEASIBILITY OF LEFT POSTERIOR FASCICULAR PACING: A PROSPECTIVE SINGLE CENTER STUDY
- Author
-
Kenneth A. Ellenbogen, Richard K. Shepard, Santosh K. Padala, Atul Verma, Gautham Kalahasty, Jayanthi N. Koneru, Ajay Pillai, Jordana Kron, and Jeffrey Kolominsky
- Subjects
business.industry ,Physiology (medical) ,Medicine ,Left posterior ,Cardiology and Cardiovascular Medicine ,Single Center ,Nuclear medicine ,business - Published
- 2021
45. B-PO03-086 AV JUNCTION ABLATION IN PATIENTS WITH CONDUCTION SYSTEM PACING LEADS: A COMPARISON OF HIS BUNDLE VS LEFT BUNDLE BRANCH AREA PACING LEADS
- Author
-
Atul Verma, Chau N. Vo, Todd L. Teigeler, Jordana Kron, Richard K. Shepard, Santosh K. Padala, Jeffrey Kolominsky, Vivak Master, Ajay Pillai, Kenneth A. Ellenbogen, Gautham Kalahasty, and Jayanthi N. Koneru
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Ablation ,Physiology (medical) ,Bundle ,Internal medicine ,Left bundle branch ,medicine ,Cardiology ,In patient ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
46. B-PO05-037 ELECTROCARDIOGRAPHIC CHARACTERISTICS WITH LEFT BUNDLE BRANCH AREA PACING: A SINGLE CENTER PROSPECTIVE STUDY
- Author
-
Jordana Kron, Kenneth A. Ellenbogen, Atul Verma, Jayanthi N. Koneru, Jeffrey Kolominsky, Ajay Pillai, Santosh K. Padala, Gautham Kalahasty, and Richard K. Shepard
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,Internal medicine ,Left bundle branch ,Cardiology ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Prospective cohort study ,Single Center - Published
- 2021
47. Use of Intravenous Cangrelor as Antiplatelet Bridge Therapy in a Patient Undergoing Esophageal Dilation Procedure
- Author
-
Ajay Pillai, Ion S. Jovin, Ravi Choxi, and Shafeeq Ahmed
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cangrelor ,medicine ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,medicine.diagnostic_test ,business.industry ,Esophagogastroduodenoscopy ,Percutaneous coronary intervention ,Stent ,General Medicine ,medicine.disease ,Dysphagia ,Surgery ,Bridge (graph theory) ,chemistry ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Ticagrelor ,medicine.drug - Abstract
Peri-procedural management of dual antiplatelet therapy following percutaneous coronary intervention for esophagogastroduodenoscopy and intervention is not clearly defined. We describe a case of a patient with a drug-eluting stent implanted in the setting of an acute myocardial infarction six weeks earlier who was bridged with cangrelor after interruption of ticagrelor for esophageal balloon dilatation because of dysphagia. The patient tolerated the procedure well and was transitioned back to ticagrelor without any complications.
- Published
- 2020
48. AUTONOMIC MODULATION FOR THE TREATMENT OF REFRACTORY VENTRICUALR ELECTRICAL STORM
- Author
-
Kenneth A. Ellenbogen, Jayanthi N. Koneru, Ajay Pillai, and Santosh K. Padala
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Storm ,Autonomic modulation ,Cardiology and Cardiovascular Medicine ,business ,Refractory (planetary science) - Published
- 2021
49. SAFETY AND FEASIBILITY OF LEFT POSTERIOR FASCICULAR PACING: A PROSPECTIVE SINGLE CENTER STUDY
- Author
-
Jayanthi N. Koneru, Kenneth A. Ellenbogen, Ajay Pillai, Jordana Kron, Richard B. Shepard, Gautham Kalahasty, and Santosh K. Padala
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Radiology ,Left posterior ,Cardiology and Cardiovascular Medicine ,Single Center ,business - Published
- 2021
50. UTILITY OF NON-INVASIVE MARKERS OF VOLUME STATUS TO PREDICT ATRIAL FIBRILLATION RECURRENCE AFTER DIRECT CURRENT CARDIOVERSION
- Author
-
Ajay Pillai, Zachary M. Gertz, Michael E. Sternberg, and Sergei Airapetov
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Direct current cardioversion ,Non invasive ,medicine ,Intravascular volume status ,Cardiology ,Atrial fibrillation ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2021
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