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1. Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion

Author

Poonam N. Desai, Bofei Wang, Andre Fonseca, Pamella Borges, Fatima Zahra. Jelloul, Patrick K. Reville, Eric Lee, Christopher Ly, Akshay Basi, Jessica Root, Natalia Baran, Sean M. Post, Qing Deng, Hanxiao Sun, Arif O. Harmanci, Jared K. Burks, Javier A. Gomez, Courtney D. DiNardo, Naval G. Daver, Gheath Alatrash, Marina Konopleva, Michael R. Green, Dinler A. Antunes, Andrew Futreal, Dapeng Hao, and Hussein A. Abbas

Subjects
Cancer Research, Immunology
Abstract

Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+ T cells from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) and 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting

Published
2023

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