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3. Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes

Author

Markmann, James F., Rickels, Michael R., Eggerman, Thomas L., Bridges, Nancy D., Lafontant, David E., Qidwai, Julie, Foster, Eric, Clarke, William R., Kamoun, Malek, Alejandro, Rodolfo, Bellin, Melena D., Chaloner, Kathryn, Czarniecki, Christine W., Goldstein, Julia S., Hering, Bernhard J., Hunsicker, Lawrence G., Kaufman, Dixon B., Korsgren, Olle, Larsen, Christian P., Luo, Xunrong, Naji, Ali, Oberholzer, José, Posselt, Andrew M., Ricordi, Camillo, Senior, Peter A., Shapiro, A.M. James, Stock, Peter G., and Turgeon, Nicole A.

Published
2021
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4. The demise of islet allotransplantation in the United States: A call for an urgent regulatory update

Author

Witkowski, Piotr, Philipson, Louis H., Kaufman, Dixon B., Ratner, Lloyd E., Abouljoud, Marwan S., Bellin, Melena D., Buse, John B., Kandeel, Fouad, Stock, Peter G., Mulligan, David C., Markmann, James F., Kozlowski, Tomasz, Andreoni, Kenneth A., Alejandro, Rodolfo, Baidal, David A., Hardy, Mark A., Wickrema, Amittha, Mirmira, Raghavendra G., Fung, John, Becker, Yolanda T., Josephson, Michelle A., Bachul, Piotr J., Pyda, Jordan S., Charlton, Michael, Millis, J. Michael, Gaglia, Jason L., Stratta, Robert J., Fridell, Jonathan A., Niederhaus, Silke V., Forbes, Rachael C., Jayant, Kumar, Robertson, R. Paul, Odorico, Jon S., Levy, Marlon F., Harland, Robert C., Abrams, Peter L., Olaitan, Oyedolamu K., Kandaswamy, Raja, Wellen, Jason R., Japour, Anthony J., Desai, Chirag S., Naziruddin, Bashoo, Balamurugan, Appakalai N., Barth, Rolf N., and Ricordi, Camillo

Published
2021
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5. Contributors

Author

Actis, Giovanni Clemente, primary, Ahsan, Nusrat, additional, Alejandro, Rodolfo, additional, Armandi, Angelo, additional, Ascani, Stefano, additional, Aversa, Tommaso, additional, Bashir, Mohammad, additional, Beetler, Danielle J., additional, Beltrami, Marina, additional, Bizzaro, Nicola, additional, Bonanno, Carmen, additional, Bonifaz, Alexandro, additional, Brenner, Michael J., additional, Bruno, Katelyn A., additional, Calcagno, Tess Moore, additional, Carmona-Cruz, Silvia Angélica, additional, Casto, Celeste, additional, Corica, Domenico, additional, Di Stadio, Arianna, additional, Fabbri, Andrea, additional, Fairweather, DeLisa, additional, Fayed, Ahmed, additional, García-Romero, María Teresa, additional, Greco, Antonio, additional, Hegazy, Mohamed Tharwat, additional, Howard, Callum, additional, Hussein, Mohamed A., additional, Idhrees, Mohammed, additional, Infante, Marco, additional, Jamee, Mahnaz, additional, Karthik, Prassana, additional, Maccora, Ilaria, additional, Marrani, Edoardo, additional, Mastrolia, Maria Vincenza, additional, Meharban, Nehman, additional, Mirsaeidi, Mehdi, additional, Momoh, Emmanuel Keddy, additional, Munir, Wahaj, additional, Pagnini, Ilaria, additional, Pakdel, Farzad, additional, Palicelli, Andrea, additional, Pepe, Giorgia, additional, Picca, Leonardo, additional, Pirmarzdashti, Niloofar, additional, Pizarro, Theresa T., additional, Pomi, Alessandra Li, additional, Quartuccio, Luca, additional, Ragab, Gaafar, additional, Ralli, Massimo, additional, Rezaei, Nima, additional, Ribaldone, Davide Giuseppe, additional, Ricordi, Camillo, additional, Sanguedolce, Francesca, additional, Santoro, Jonathan D., additional, Sheridan, Jonathan, additional, Simonini, Gabriele, additional, Soriano, Alessandra, additional, Soriano, Marco, additional, Sullivan, Timothy J., additional, Tirado-Sánchez, Andrés, additional, Tozzoli, Renato, additional, Tropeano, Angelo, additional, Valenzise, Mariella, additional, Wasniewska, Malgorzata, additional, Yazdanpanah, Niloufar, additional, Zanelli, Magda, additional, and Zizzo, Maurizio, additional

Published
2022
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7. Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

Author

Hering, Bernhard J, Clarke, William R, Bridges, Nancy D, Eggerman, Thomas L, Alejandro, Rodolfo, Bellin, Melena D, Chaloner, Kathryn, Czarniecki, Christine W, Goldstein, Julia S, Hunsicker, Lawrence G, Kaufman, Dixon B, Korsgren, Olle, Larsen, Christian P, Luo, Xunrong, Markmann, James F, Naji, Ali, Oberholzer, Jose, Posselt, Andrew M, Rickels, Michael R, Ricordi, Camillo, Robien, Mark A, Senior, Peter A, Shapiro, AM James, Stock, Peter G, and Turgeon, Nicole A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Autoimmune Disease, Transplantation, Clinical Trials and Supportive Activities, Diabetes, Metabolic and endocrine, Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Immunosuppression Therapy, Islets of Langerhans Transplantation, Male, Middle Aged, North America, Young Adult, Clinical Islet Transplantation Consortium, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveImpaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D). Current therapies are effective in preventing SHEs in 50-80% of patients with IAH and SHEs, leaving a substantial number of patients at risk. We evaluated the effectiveness and safety of a standardized human pancreatic islet product in subjects in whom IAH and SHEs persisted despite medical treatment.Research design and methodsThis multicenter, single-arm, phase 3 study of the investigational product purified human pancreatic islets (PHPI) was conducted at eight centers in North America. Forty-eight adults with T1D for >5 years, absent stimulated C-peptide, and documented IAH and SHEs despite expert care were enrolled. Each received immunosuppression and one or more transplants of PHPI, manufactured on-site under good manufacturing practice conditions using a common batch record and standardized lot release criteria and test methods. The primary end point was the achievement of HbA1c 0.0001). No study-related deaths or disabilities occurred. Five of the enrollees (10.4%) experienced bleeds requiring transfusions (corresponding to 5 of 75 procedures), and two enrollees (4.1%) had infections attributed to immunosuppression. Glomerular filtration rate decreased significantly on immunosuppression, and donor-specific antibodies developed in two patients.ConclusionsTransplanted PHPI provided glycemic control, restoration of hypoglycemia awareness, and protection from SHEs in subjects with intractable IAH and SHEs. Safety events occurred related to the infusion procedure and immunosuppression, including bleeding and decreased renal function. Islet transplantation should be considered for patients with T1D and IAH in whom other, less invasive current treatments have been ineffective in preventing SHEs.

Published
2016

8. Improved Human Islet Preparations Using Glucocorticoid and Exendin-4

Author

Miki, Atsushi, Ricordi, Camillo, Yamamoto, Toshiyuki, Sakuma, Yasunaru, Misawa, Ryosuke, Mita, Atsuyoshi, Inverardi, Luca, Alejandro, Rodolfo, and Ichii, Hirohito

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Autoimmune Disease, Transplantation, Metabolic and endocrine, Cell Culture Techniques, Cell Survival, Chemokines, Culture Media, Cytokines, Exenatide, Glucose, Humans, Inflammation Mediators, Insulin, Insulin Secretion, Islets of Langerhans, MAP Kinase Signaling System, Methylprednisolone, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Peptides, Phosphoproteins, Phosphorylation, Protein Processing, Post-Translational, Venoms, culture, glucagon-like peptide-1, cytokine, insulin secretion, islet function, beta-cell viability, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesThe effects of glucocorticoid during culture on human islet cells have been controversial. Exendin-4 (EX) enhances the insulin secretion and significantly improves clinical outcomes in islet cell transplantation. In this study, we examined the effects of glucocorticoids and EX on human islet cells during pretransplant culture.MethodsMethylprednisolone (MP) and/or EX were added to the standard culture medium for clinical islet cell transplantation. Islets were cultured for 24 hours with 3 different conditions (control, no additives; MP alone; and MP + EX). β-Cell fractional viability, cellular composition, multiple cytokine/chemokine production, multiple phosphorylation proteins, and glucose-induced insulin secretion were evaluated.ResultsViable β-cell survival in MP and MP + EX group was significantly higher than in the control group. Exendin-4 prevented MP-induced reduction of insulin secretion. Methylprednisolone supplementation to the culture medium decreased cytokine and chemokine production. Moreover, extracellular signal-regulated kinase 1/2 phosphorylation was significantly increased by MP and MP + EX.ConclusionsGlucocorticoid supplementation into culture media significantly decreased the cytokine/chemokine production and increased the extracellular signal-regulated kinase 1/2 phosphorylation, resulting in the improvement of human β-cell survival. In addition, EX maintained the insulin secretion suppressed by MP. The supplementation of MP and EX together could be a useful strategy to create suitable human islets for transplantation.

Published
2014

9. Acute bilateral Irvine-Gass Syndrome following uneventful cataract surgery in a patient without systemic risk factors

Author

Alejandro Rodolfo Allocco and Mauricio Gabriel Magurno

Subjects
Cystoid macular edema, Irvine-Gass syndrome, Cataract extraction, Phacoemulsification, Ophthalmology, RE1-994
Abstract

Abstract We herein report a patient without risk factors who presented acute bilateral Irvine-Gass syndrome after uneventful phacoemulsification. The novelty of our case lies on the fact that the patient presented acute bilateral Irvine-Gass syndrome without a predisposing systemic disease. Even though Cystoid Macular Edema (CME) was somehow expected in the first eye because of the ocular history of trauma, prophylactic measures were not strong enough to avoid its development. Furthermore, those measures could not avoid developing CME in the second eye. A 44-years-old male who underwent cataract surgery in both eyes presented bilateral Irvine-Gass syndrome. Despite prophylactic measures, both eyes developed CME after uneventful cataract surgery. Regular treatment options could not solve the situation and intravitreal Anti-VEGF injections were needed. Bilateral cases of Irvine-Gass Syndrome are rare and generally associated with systemic risk factors. Patients who developed CME following their first cataract surgery should be counseled about the risks of developing the condition following surgery on the contralateral eye. On top of that, aggressive prophylactic measures should be encouraged to prevent CME in these cases.

Published
2019
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11. Improvement in outcomes of clinical islet transplantation: 1999-2010.

Author

Barton, Franca, Rickels, Michael, Alejandro, Rodolfo, Hering, Bernhard, Wease, Stephen, Naziruddin, Bashoo, Oberholzer, Jose, Odorico, Jon, Garfinkel, Marc, Levy, Marlon, Pattou, Francois, Berney, Thierry, Secchi, Antonio, Messinger, Shari, Senior, Peter, Maffi, Paola, Kaufman, Dixon, Luo, Xunrong, Kandeel, Fouad, Cagliero, Enrico, Turgeon, Nicole, Witkowski, Piotr, Naji, Ali, OConnell, Philip, Greenbaum, Carla, Kudva, Yogish, Brayman, Kenneth, Aull, Meredith, Larsen, Christian, Kay, Tom, Fernandez, Luis, Vantyghem, Marie-Christine, Bellin, Melena, Shapiro, A, Stock, Peter, and Posselt, Andrew

Subjects
Adolescent, Adult, Aged, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Islets of Langerhans Transplantation, Middle Aged, Registries, Treatment Outcome
Abstract

OBJECTIVE: To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS: A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS: Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA(1c) and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS: The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient.

Published
2012

12. Impact of GAD65 and IA2 autoantibodies on islet allograft survival

Author

Lemos, Joana R. N., primary, Poggioli, Raffaella, additional, Ambut, Jonathan, additional, Bozkurt, Nujen C., additional, Alvarez, Ana M., additional, Padilla, Nathalia, additional, Vendrame, Francesco, additional, Ricordi, Camillo, additional, Baidal, David A., additional, and Alejandro, Rodolfo, additional

Published
2023
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13. Seguimiento de trayectorias estudiantiles en Moodle para el programa de la MTIE

Author

Raúl Armando Valadez Estrada, Susana Cordero Dávila, José de Jesús Hernández Berumen, Alejandro Rodolfo García Villalobos, and Martha Susana Hernández Larios

Subjects
Marketing, Pharmacology, Organizational Behavior and Human Resource Management, Strategy and Management, Drug Discovery, Pharmaceutical Science
Abstract

La presente investigación pretende conocer las necesidades del programa de la Maestría en Tecnología Informática Educativa de la Universidad Autónoma de Zacatecas en lo que respecta al seguimiento de trayectorias estudiantiles de sus alumnos de la modalidad en línea, así como, los requisitos técnicos para desarrollar e implementar un programa conector (plugin) que permita realizar dicho seguimiento en tiempo real en la plataforma LMS Moodle en la que opera dicho programa.

Published
2023
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14. Implementación de insignias digitales en el LMS Moodle

Author

Susana Cordero Davila, Raúl Armando Valadez Estrada, Martha Susana Hernandez Larios, Alejandro Rodolfo Garcia Villalobos, and José de Jesús Hernández Berumen

Subjects
Marketing, Pharmacology, Organizational Behavior and Human Resource Management, Strategy and Management, Drug Discovery, Pharmaceutical Science
Abstract

La presente investigación describe el procedimiento para la implementación de insignias digitales en el Sistema de Gestión de Aprendizaje (LMS) Moodle en la materia de Aplicaciones Tecnológicas en la Educación de la Maestría en Tecnología Informática Educativa (MTIE) de la Universidad Autónoma de Zacatecas (UAZ) como una estrategia motivacional que propicie el cambio de comportamiento a nivel competitivo en los estudiantes, así como, mejorar su proceso de aprendizaje. Dicha investigación es de tipo descriptiva documental en la que se detallará de manera general el proceso para la implementación de insignias digitales en una plataforma LMS Moodle.

Published
2023
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15. Contributors

Author

Abrams, Peter, primary, Adler, Joel T., additional, Alejandro, Rodolfo, additional, Alibashe-Ahmed, Mohamed, additional, Alvarez, Ana, additional, Anazawa, Takayuki, additional, Andres, Axel, additional, Antonioli, Barbara, additional, Apete, Alan, additional, Axelrod, David A., additional, Badet, Lionel, additional, Baidal, David, additional, Barrera, Kaylene, additional, Benhamou, Pierre-Yves, additional, Berney, Thierry, additional, Bertoni, Alain Gerald, additional, Bertuzzi, Federico, additional, Boggi, Ugo, additional, Bonner, Caroline, additional, Bozorgzadeh, Adel, additional, Branchereau, Julien, additional, Bromberg, Jonathan, additional, Burke, George W., additional, Buron, Fanny, additional, Caiazzo, Robert, additional, Caldara, Rossana, additional, Camhi, Stephanie S., additional, Cantarovich, Diego, additional, Cardillo, Massimo, additional, Castanares-Zapatero, D., additional, Cattan, Pierre, additional, Chandran, Suresh Rama, additional, Chang, Erin, additional, Chen, Linda, additional, Chetboun, Mikael, additional, Choudhary, Pratik, additional, Ciancio, Gaetano, additional, Cicalese, Maria Pia, additional, Citro, Antonio, additional, Collienne, C., additional, Conte, Caterina, additional, Counter, Claire, additional, Dajani, Khaled Z., additional, Darden, Carly M., additional, De Cobelli, Francesco, additional, de Koning, Eelco J.P., additional, De Leon, Hector, additional, Delalleau, Nathalie, additional, DiChiacchio, Laura, additional, Doppenberg, Jason B., additional, Drachenberg, Cinthia B., additional, Dugnani, Erica, additional, Dunn, Ty B., additional, Engelse, Marten A., additional, Farag, Ahmed, additional, Farney, Alan, additional, Farrow, Anne Elizabeth, additional, Fathi, Ibrahim, additional, Figueiro, Jose, additional, Flatt, Anneliese, additional, Fousteri, Georgia, additional, Fridell, Jonathan A., additional, Friend, Peter J., additional, Gastaldi, Giacomo, additional, Gmyr, Valery, additional, Gonzalez, Javier, additional, Gopal, Jeevan Prakash, additional, Gorus, Frans K., additional, Goto, Masafumi, additional, Gotoh, Mitsukazu, additional, Greget, Michel, additional, Grenet, Dominique, additional, Grossi, Paolo Antonio, additional, Gruessner, Rainer W.G., additional, Gruessner, Angelika C., additional, Harriman, David I., additional, Hawthorne, Wayne J., additional, Hellman, Jarl, additional, Holbert, Brenda Lee, additional, Hubert, Thomas, additional, Iacopi, Sara, additional, Infante, Marco, additional, Jacob, Peter, additional, Johnson, Paul, additional, Kandaswamy, Raja, additional, Karam, Georges, additional, Kaufman, Dixon B., additional, Kendall Jr, W.F., additional, Kensinger, Clark D., additional, Kenyon, Norma S., additional, Kerr-Conte, Julie, additional, Kervella, Delphine, additional, Kessler, Laurence, additional, Kessler, Romain, additional, Keymeulen, Bart, additional, Korsgren, Olle, additional, Lablanche, Sandrine, additional, Lakhani, Muhaib, additional, Lalwani, Neeraj, additional, Laterre, P.F., additional, Lawrence, Michael C., additional, Lee, Frances Tangherlini, additional, Lehmann, Roger, additional, Linetsky, Elina, additional, Ludwig, Barbara, additional, Lundgren, Torbjörn, additional, Luo, Xunrong, additional, Madiraju, SriGita, additional, Maffi, Paola, additional, Magistretti, Paola, additional, Mapihan, Kristell Le, additional, Markmann, James F., additional, Martens, Geert, additional, Martins, Paulo N., additional, Mazzotta, Francesco Antonio, additional, Mekala, Kavya Chitra, additional, Melzi, Raffaella, additional, Mercalli, Alessia, additional, Monti, Paolo, additional, Morsi, Mahmoud, additional, Mosca, Irene, additional, Mourad, M., additional, Muthusamy, Anand S. Rathnasamy, additional, Nano, Rita, additional, Naziruddin, Bashoo, additional, Noel, Christian, additional, O’Callaghan, John, additional, Odorico, Jon S., additional, Olland, Anne, additional, Opara, E.C., additional, Orlando, Giuseppe, additional, Padilla, Nathalia, additional, Papadimitriou, John C., additional, Papalois, Vassilios E., additional, Papas, Klearchos K., additional, Pasquetti, Gianni, additional, Pattou, François, additional, Pellegrini, Silvia, additional, Pernin, Nadine, additional, Perrone, Vittorio Grazio, additional, Piemonti, Lorenzo, additional, Ploeg, Rutger, additional, Powelson, John A., additional, Pugliese, Alberto, additional, Rajan, Shanthini K., additional, Ramanathan, Karthik V., additional, Raverdy, Violeta, additional, Redfield, Robert R., additional, Renz, John, additional, Rickels, Michael R., additional, Rickert, Charles G., additional, Ricordi, Camillo, additional, Rogers, Jeffrey, additional, Scalea, Joseph R., additional, Schold, Jesse D., additional, Scholz, Hanne, additional, Secchi, Antonio, additional, Serrano, Oscar K., additional, Shapiro, A.M. James, additional, Sharma, Sidharth, additional, Sharples, Edward, additional, Shaw, James A.M., additional, Sinha, Sanjay, additional, Socci, Carlo, additional, Squifflet, Jean-Paul G., additional, Stock, Peter G., additional, Stratta, Robert J., additional, Sutherland, David E.R., additional, Tesauro, Manfredi, additional, Thaunat, Olivier, additional, Thévenet, Julien, additional, Troppmann, Christoph, additional, Vantyghem, Marie-Christine, additional, Vendrame, Francesco, additional, Venturini, Massimo, additional, Vianna, Rodrigo, additional, Vistoli, Fabio, additional, von Zur-Mühlen, Bengt, additional, Wittebole, X., additional, Wojtusciszyn, Anne, additional, Zarinsefat, Arya, additional, and Zimmerman, Asha, additional

Published
2020
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16. A biologic resorbable scaffold for tissue engineering of the endocrine pancreas: Clinical experience of islet transplantation on the omentum

Author

Baidal, David A., primary, Infante, Marco, additional, Fuenmayor, Virginia, additional, Alvarez, Ana M., additional, Padilla, Nathalia, additional, Berman, Dora M., additional, Pileggi, Antonello, additional, Linetsky, Elina, additional, Ciancio, Gaetano, additional, Ricordi, Camillo, additional, and Alejandro, Rodolfo, additional

Published
2020
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18. Contributors

Author

Adachi, Tomohiko, primary, Adachi, Toshiyuki, additional, Alejandro, Rodolfo, additional, Alvarez, Ana M., additional, Alvaro, Domenico, additional, Andrei, Spencer R., additional, Armfield, Matthew, additional, Asthana, Amish, additional, Badylak, Stephen F., additional, Baidal, David A., additional, Balamurugan, Appakalai N., additional, Balzano, Gianpaolo, additional, Banerjee, Ipsita, additional, Barrera, Kaylene, additional, Bataller, Will, additional, Beilman, Greg J., additional, Bellin, Melena D., additional, Berman, Dora M., additional, Berry, Louise, additional, Bojar, Daniel, additional, Bottino, Rita, additional, Brigle, Nathaniel W., additional, Buchwald, Henry, additional, Buchwald, Jane N., additional, Cardinale, Vincenzo, additional, Carpino, Guido, additional, Cercone, Renee, additional, Chaimov, Deborah, additional, Chapman, Christopher G., additional, Child, Amanda, additional, Chinnakotla, Srinath, additional, Ciancio, Gaetano, additional, Colling, Kristin P., additional, Cook, Marie, additional, Cooper, David K.C., additional, Coughlan, Alexandria, additional, de Vries, Rick, additional, Domínguez-Bendala, Juan, additional, Dunn, Ty B., additional, Eguchi, Susumu, additional, Falconi, Massimo, additional, Feeney, Austin K., additional, Fontaine, Magali J., additional, Freedman, Benjamin S., additional, Fuenmayor, Virginia, additional, Fussenegger, Martin, additional, Gannon, Maureen, additional, Gauido, Eugenio, additional, Goedde, Michael A., additional, Gruessner, Rainer W.G., additional, Hermanns, Carolin, additional, Hidaka, Masaaki, additional, Hirabaru, Masataka, additional, Hughes, Michael G., additional, Hussain, Abid, additional, Imamura, Hajime, additional, Infante, Marco, additional, Janani, G., additional, Jetten, Marlon, additional, Jones, Christopher M., additional, Kalivarathan, Jagan, additional, Kanak, Mazhar A., additional, Kaplan, David L., additional, Kin, Tatsuya, additional, Kumar, Manishekhar, additional, Lakey, Jonathan R.T., additional, Lanzoni, Giacomo, additional, Larkin, Emily J., additional, Latres, Esther, additional, Lee, Yoojin C., additional, Linetsky, Elina, additional, Loganathan, Gopalakrishnan, additional, Maillard, Elisa, additional, Mandal, Biman B., additional, Martinez, Adela Helvia, additional, Matsushima, Hajime, additional, Matthews, Jeffrey B., additional, McEachron, Kendall, additional, Melzi, Raffaella, additional, Mercalli, Alessia, additional, Migliaccio, Giovanni, additional, Mitchell, Samantha A., additional, Mohammed, Sami, additional, Muir, Sean, additional, Nano, Rita, additional, Narayanan, Siddharth, additional, Natsuda, Koji, additional, Odorico, Jon S., additional, Ono, Shinichiro, additional, Orlando, Giuseppe, additional, Padilla, Nathalia, additional, Pellegrini, Silvia, additional, Perin, Laura, additional, Piemonti, Lorenzo, additional, Pileggi, Antonello, additional, Pineda Molina, Catalina, additional, Poli, Elizabeth C., additional, Qadir, Mirza Muhammad Fahd, additional, Ricordi, Camillo, additional, Rilo, L. Rodriguez, additional, Robertson, R. Paul, additional, Rust, William, additional, Sackett, Sara Dutton, additional, Saxena, Pratik, additional, Schwartzman, Alexander, additional, Schwarzenberg, Sarah J., additional, Sefton, Michael V., additional, Sharma, Sidharth, additional, Smood, Benjamin, additional, Socci, Davide, additional, Sordi, Valeria, additional, Stell, Adam, additional, Stock, Aaron A., additional, Takatsuki, Mitsuhisa, additional, Tomei, Alice A., additional, Tremmel, Daniel M., additional, Tuch, Bernard E., additional, Vaithilingam, Vijayaganapathy, additional, van Apeldoorn, Aart, additional, Villani, Valentina, additional, Vlahos, Alexander E., additional, Williams, Stuart K., additional, Xiao, Xiangwei, additional, Yadav, Kunal, additional, Yamashita, Manpei, additional, and Zulewski, Henryk, additional

Published
2020
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22. Matching for HLA-DR excluding diabetogenic HLA-DR3 and HLA-DR4 predicts insulin independence after pancreatic islet transplantation

Author

Ballou, Cassandra, primary, Barton, Franca, additional, Payne, Elizabeth H., additional, Berney, Thierry, additional, Villard, Jean, additional, Meier, Raphael P. H., additional, Baidal, David, additional, Alejandro, Rodolfo, additional, Robien, Mark, additional, Eggerman, Thomas L., additional, Kamoun, Malek, additional, and Muller, Yannick D., additional

Published
2023
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30. Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop

Author

Rickels, Michael R., Stock, Peter G., de Koning, Eelco J.P., Piemonti, Lorenzo, Pratschke, Johann, Alejandro, Rodolfo, Bellin, Melena D., Berney, Thierry, Choudhary, Pratik, Johnson, Paul R., Kandaswamy, Raja, Kay, Thomas W.H., Keymeulen, Bart, Kudva, Yogish C., Latres, Esther, Langer, Robert M., Lehmann, Roger, Ludwig, Barbara, Markmann, James F., Marinac, Marjana, Odorico, Jon S., Pattou, François, Senior, Peter A., Shaw, James A.M., Vantyghem, Marie-Christine, and White, Steven

Published
2018
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31. Long-Term Outcomes with Islet-Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: the CIT08 Study

Author

Rickels, Michael R., primary, Eggerman, Thomas L., primary, Bayman, Levent, primary, Qidwai, Julie C., primary, Alejandro, Rodolfo, primary, Bridges, Nancy D., primary, Hering, Bernhard J., primary, Markmann, James F., primary, Senior, Peter A., primary, Hunsicker, Lawrence G., primary, and Consortium, the Clinical Islet Transplantation, primary

Published
2022
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32. Factors associated with favourable 5 year outcomes in islet transplant alone recipients with type 1 diabetes complicated by severe hypoglycaemia in the Collaborative Islet Transplant Registry

Author

Hering, Bernhard J., primary, Ballou, Cassandra M., additional, Bellin, Melena D., additional, Payne, Elizabeth H., additional, Kandeel, Fouad, additional, Witkowski, Piotr, additional, Alejandro, Rodolfo, additional, Rickels, Michael R., additional, and Barton, Franca B., additional

Published
2022
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33. Islet Transplantation

Author

Berney, Thierry, Kenyon, Norma Sue, Alejandro, Rodolfo, Inverardi, Luca, Mintz, Daniel H., Ricordi, Camillo, Conn, P. Michael, editor, and Sperling, Mark A., editor

Published
2003
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34. Systematic Literature Review on The Short Pasta Noodles Reinforced with Seaweed.

Author

Janampa-Salvatierra, Angelo Jean Pierr, Lamas-Vidalon, Alejandro Rodolfo, and Collao-Diaz, Martín Fidel

Subjects
PASTA products, NOODLES, MARINE algae, DURUM wheat
Abstract

In the present research, through a systematic literature review, we seek to describe the application of seaweed in the production of noodles, as an alternative to traditional preparation and to improve the nutritional content of noodles. For this, in the first place, papers were extracted from different databases such as Scopus and Google Scholar. Then, the most relevant information was analyzed and extracted from each scientific article. With this information, the objectives were answered. Finally, the results were analyzed in detail and the doors were opened for new research on noodles reinforced with seaweed, but centralized in Peru. Thanks to this research, it can be said that the application of seaweed in small proportions (<= 5%) is beneficial at the nutritional level, since it increases the amount of proteins, fiber and minerals, as well as decreases the amount of carbohydrates and fats. [ABSTRACT FROM AUTHOR]

Published
2023

37. Desarrollo de habilidades socioemocionales a través de un curso de tutorías B-Learning para alumnos de nivel Bachillerato de la Universidad Autónoma de Zacatecas 'Francisco García Salinas': Estudio realizado en el Programa de Preparatoria No. XIII

Author

Alejandro Rodolfo García-Villalobos, Martha Susana Hernández-Larios, Esmelda Barrios-García, and José de Jesús Hernández-Berumen

Subjects
General Mathematics, ComputingMilieux_COMPUTERSANDEDUCATION
Abstract

As part of the institutional strategy to prevent failure and school dropout, seeking better academic performance by upper-secondary students, a project is established where the tutorial part is related to the use of technological tools and resources. A course in B-Learning is developed, developing strategies that modify their behavior and performance, said course consists of four units, where strategies are developed to improve attention, identify emotions and the strategies necessary for their concentration, allowing them to develop social-emotional skills achieving better academic performance.

Published
2020
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41. Predictive Value of C-Peptide Measures for Clinical Outcomes of β-Cell Replacement Therapy in Type 1 Diabetes: Report From the Collaborative Islet Transplant Registry (CITR).

Author

Baidal, David A., Ballou, Cassandra M., Rickels, Michael R., Berney, Thierry, Pattou, Francois, Payne, Elizabeth H., Barton, Franca B., and Alejandro, Rodolfo

Subjects
TYPE 1 diabetes, C-peptide, ISLANDS, RECEIVER operating characteristic curves, GLYCEMIC control
Abstract

OBJECTIVE: To determine C-peptide measures and levels associated with positive glycemic control outcomes following islet transplant (ITx) in type 1 diabetes. RESEARCH DESIGN AND METHODS: We evaluated Collaborative Islet Transplant Registry (CITR) islet-alone recipients with pretransplant C-peptide <0.1 nmol/L and mean follow-up of 4.6 ± 1.1 years (n = 677). Receiver operating characteristic area under the curve (ROC-AUC) was used to evaluate the predictive value of fasting and stimulated glucose and C-peptide measures for seven primary outcomes: 1) absence of severe hypoglycemic events (ASHEs); 2) HbA1c <7.0%; 3) HbA1c <7.0% and ASHEs; 4) HbA1c ≤6.5%; 5) HbA1c ≤6.5% and ASHEs; 6) insulin independence; and 7) ASHEs, HbA1c ≤6.5%, and insulin independence (the optimal outcome). Measures with the highest ROC-AUC were selected for determination of optimal cut points. RESULTS: Fasting C-peptide was highly predictive for ASHE (ROC-AUC 0.906; optimal cut point 0.070 nmol/L) and the optimal outcome (ROC-AUC 0.845; optimal cut point 0.33 nmol/L). Mixed-meal tolerance test (MMTT)–stimulated C-peptide-to-glucose ratio (CPGR) outperformed both fasting and stimulated C-peptide for all outcomes except ASHE. The optimal cut point for the optimal outcome was 0.12 nmol/mmol for MMTT-stimulated CPGR and 0.97 nmol/L for MMTT-stimulated C-peptide. CONCLUSIONS: Fasting C-peptide reliably predicts ITx primary outcomes. MMTT-stimulated CPGR provides marginally better prediction for composite ITx outcomes, including insulin independence. In the absence of an MMTT, a fasting C-peptide ≥0.33 nmol/L is a reassuring measure of optimal islet graft function. C-peptide targets represent excellent and easily determinable means to predict glycemic control outcomes after ITx and should be considered as potential goals of β-cell replacement. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Matching for HLA-DR excluding diabetogenic HLA-DR3 and HLADR4 predicts insulin independence after pancreatic islet transplantation.

Author

Ballou, Cassandra, Barton, Franca, Payne, Elizabeth H., Berney, Thierry, Villard, Jean, Meier, Raphael P. H., Baidal, David, Alejandro, Rodolfo, Robien, Mark, Eggerman, Thomas L., Kamoun, Malek, and Muller, Yannick D.

Subjects
ISLANDS of Langerhans, HLA-DR antigens, HLA histocompatibility antigens, TYPE 1 diabetes, INSULIN
Abstract

Introduction: In pancreatic islet transplantation, the exact contribution of human leukocyte antigen (HLA) matching to graft survival remains unclear. Islets may be exposed to allogenic rejection but also the recurrence of type 1 diabetes (T1D). We evaluated the HLA-DR matching, including the impact of diabetogenic HLADR3 or HLA-DR4 matches. Methods: We retrospectively examined the HLA profile in 965 transplant recipients and 2327 islet donors. The study population was obtained from patients enrolled in the Collaborative Islet Transplant Registry. We then identified 87 recipients who received a single-islet infusion. Islet-kidney recipients, 2nd islet infusion, and patients with missing data were excluded from the analysis (n=878). Results: HLA-DR3 and HLA-DR4 were present in 29.7% and 32.6% of T1D recipients and 11.6% and 15.8% of the donors, respectively. We identified 52 T1D islet recipients mismatched for HLA-DR (group A), 11 with 1 or 2 HLA-DRmatches but excluding HLA-DR3 and HLA- DR4 (group B), and 24 matched for HLA-DR3 or HLA-DR4 (group C). Insulin-independence was maintained in a significantly higher percentage of group B recipients from year one through five post-transplantation (p<0.01). At five-year post-transplantation, 78% of group B was insulin-independent compared to 24% (group A) and 35% (group C). Insulinindependence correlated with significantly better glycemic control (HbA1c <7%), fasting blood glucose, and reduced severe hypoglycemic events. Matching HLAA-B-DR (≥3) independently of HLA- DR3 or HLA-DR4 matching did not improve graft survival. Conclusion: This study suggests that matching HLA-DR but excluding the diabetogenic HLA-DR3 and/or 4 is a significant predictor for long-term islet survival. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress

Author

Witkowski, Piotr, primary, Philipson, Louis H., additional, Buse, John B., additional, Robertson, R. Paul, additional, Alejandro, Rodolfo, additional, Bellin, Melena D., additional, Kandeel, Fouad, additional, Baidal, David, additional, Gaglia, Jason L., additional, Posselt, Andrew M., additional, Anteby, Roi, additional, Bachul, Piotr J., additional, Al-Salmay, Yaser, additional, Jayant, Kumar, additional, Perez-Gutierrez, Angelica, additional, Barth, Rolf N., additional, Fung, John J., additional, and Ricordi, Camillo, additional

Published
2022
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44. Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: The CIT-08 Study.

Author

Rickels, Michael R., Eggerman, Thomas L., Bayman, Levent, Qidwai, Julie C., Alejandro, Rodolfo, Bridges, Nancy D., Hering, Bernhard J., Markmann, James F., Senior, Peter A., Hunsicker, Lawrence G., AvilaJoseBegleyBethCanoJoseCarpentierSallieHolbrookElizabethHutchinsonJenniferLarsenChristian P.MorenoJohannaSearsMartiTurgeonNicole A.WebsterDasiaBerneChristianJornsCarlLundgrenTorbjörnRydénMikaelCaglieroEnricoCrisalliKerryDengS.LeiJiMarkmannJa, Avila, Jose, Begley, Beth, Cano, Jose, Carpentier, Sallie, Holbrook, Elizabeth, Hutchinson, Jennifer, Larsen, Christian P., Moreno, Johanna, and Sears, Marti

Abstract

OBJECTIVE: To determine long-term outcomes for islet-alone and islet-after-kidney transplantation in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia. RESEARCH DESIGN AND METHODS: This was a prospective interventional and observational cohort study of islet-alone (n = 48) and islet-after-kidney (n = 24) transplant recipients followed for up to 8 years after intraportal infusion of one or more purified human pancreatic islet products under standardized immunosuppression. Outcomes included duration of islet graft survival (stimulated C-peptide ≥0.3 ng/mL), on-target glycemic control (HbA1c <7.0%), freedom from severe hypoglycemia, and insulin independence. RESULTS: Of the 48 islet-alone and 24 islet-after-kidney transplantation recipients, 26 and 8 completed long-term follow-up with islet graft function, 15 and 7 withdrew from follow-up with islet graft function, and 7 and 9 experienced islet graft failure, respectively. Actuarial islet graft survival at median and final follow-up was 84% and 56% for islet-alone and 69% and 49% for islet-after-kidney (P = 0.007) with 77% and 49% of islet-alone and 57% and 35% of islet-after-kidney transplantation recipients maintaining posttransplant HbA1c <7.0% (P = 0.0017); freedom from severe hypoglycemia was maintained at >90% in both cohorts. Insulin independence was achieved by 74% of islet-alone and islet-after-kidney transplantation recipients, with more than one-half maintaining insulin independence during long-term follow-up. Kidney function remained stable during long-term follow-up in both cohorts, and rates of sensitization against HLA were low. Severe adverse events occurred at 0.31 per patient-year for islet-alone and 0.43 per patient-year for islet-after-kidney transplantation. CONCLUSIONS: Islet transplantation results in durable islet graft survival permitting achievement of glycemic targets in the absence of severe hypoglycemia for most appropriately indicated recipients having impaired awareness of hypoglycemia, with acceptable safety of added immunosuppression for both islet-alone and islet-after-kidney transplantation. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Ciberdelitos 2 : Análisis doctrinario y jurisprudencial

Author

Gustavo Eduardo Aboso, Juan Manuel Chiaradia, Eric Heffle, Alejandro Rodolfo Cilleruelo, Carlos Christian Sueiro, Nora A. Cherñavsky, Javier Teodoro Álvarez, Javier Esteban Bura Peralta, Sofía Cornejo Solá, María de las Mercedes Lugones Poggi, Antonella María Bentin, María Belén Linares, Micaela Simian, Gustavo Eduardo Aboso, Juan Manuel Chiaradia, Eric Heffle, Alejandro Rodolfo Cilleruelo, Carlos Christian Sueiro, Nora A. Cherñavsky, Javier Teodoro Álvarez, Javier Esteban Bura Peralta, Sofía Cornejo Solá, María de las Mercedes Lugones Poggi, Antonella María Bentin, María Belén Linares, and Micaela Simian

Abstract

La cibercriminalidad plantea desafíos inéditos para el derecho penal en la era digital. Tras el éxito de Ciberdelitos, surge esta colección que profundiza en las complejidades delictivas de la tecnología moderna. Este segundo volumen presenta un análisis exhaustivo de las principales manifestaciones delictivas en la sociedad digital, abordando temas como los ataques cibernéticos a la propiedad (ej. denegación de servicios, estafas informáticas) desde un enfoque comparado entre Argentina y España, así como el uso malicioso de códigos QR. Se destacan estudios sobre la privacidad, con especial atención al intrusismo informático, el ataque a las comunicaciones privadas y la protección de la mujer ante la violencia digital, en sintonía con la'ley Olimpia'en la ley 26.485. En relación con la autodeterminación informativa, se analiza la tensión entre libertad de expresión y derecho al olvido, a partir del precedente'Belén Rodríguez'y la necesidad de una regulación específica. La tutela de los menores en redes sociales, frente al anonimato y los perfiles falsos que facilitan abusos y explotación, es abordada junto con la problemática de imágenes generadas por inteligencia artificial. La evidencia digital también recibe un tratamiento especial, con referencias a la normativa en Salta y el uso de datos biométricos, geolocalización y malware en el proceso penal. Finalmente, se examina el impacto de las criptomonedas en la legitimación de activos y la incautación de criptoactivos en procesos penales, destacando la urgencia de adecuar nuestra legislación penal a estos fenómenos tecnológicos.

Published
2024

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