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The synthesis, spectral characterization, and antibacterial activity of some new substituted 8-bromo-6-alkyl-isoxazolo[4,3- e]indoles are presented. Their antibacterial activity (MIC) against methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) were determined . The results revealed that compounds 3e-3h displayed greater antibacterial activity against MRSA than did the well-known antibacterial agents cephalexin and erythromycin. [ABSTRACT FROM AUTHOR]

convenient method for the synthesis of tetrahydrobenzo[ b]pyrans by a one-pot three-component cyclocondensation of dimedone, aryl aldehydes, and malononitrile in water using silica gel-supported polyphosphoric acid (PPA-SiO) as an efficient and reusable catalyst is described. The present methodology offers several advantages, such as a simple procedure with ease of handling, short reaction time, high yields, and the absence of any volatile and hazardous organic solvents. [ABSTRACT FROM AUTHOR]

Herein, we present the synthesis of nanocatalysts with a large surface area. This was achieved through an interaction involving tetraethyl orthosilicate (TEOS) and tripolyphosphate (TPP), followed by the coupling of a ruthenium acetate complex with the click-transformed ligand of filamentous phosphosilicate (FPS). As a result, Ho 3 Fe 5 O 12 nanoparticles were uniformly distributed without aggregation over FPS, forming Ho 3 Fe 5 O 12 @FPS. This substance was subsequently employed as a green nanocatalyst for the synthesis of cyclic carbonate from carbon dioxide and limonene epoxide whilst adhering to eco-friendly conditions. In the next step, we attempted to synthesize a polymer from synthesized natural cyclic carbonate. The incorporation of threadlike FPS divisions increased the ability to adsorb and aided the retrieval of the adsorbent without notably diminishing its effectiveness. The formed products were easily separated from the eco-friendly medium, and the catalyst was reused many times without a noticeable decrease in its activity and specificity., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)