166 results on '"Alonzi, Dominic S."'
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2. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
3. Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II
4. Cellular Mechanism of Glycosylation Inhibition by Imino Sugars
5. Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
6. Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
7. Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
8. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses
9. An iminosugar with potent inhibition of dengue virus infection in vivo
10. Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease
11. Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase
12. Fleetamine (3-O-α-d-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-α-mannosidase
13. Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard
14. Towards a stable noeuromycin analog with a d-manno configuration: Synthesis and glycosidase inhibition of d-manno-like tri- and tetrahydroxylated azepanes
15. Non-specific accumulation of glycosphingolipids in GNE myopathy
16. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
17. Iminosugar C ‐Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease**
18. Carbasugar–thioether pseudodisaccharides related to N-glycan biosynthesis
19. Improved cellular inhibitors for glycoprotein processing α-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
20. The role and uses of antibodies in COVID-19 infections: a living review
21. Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins
22. Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase
23. Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike
24. Mucosal immune responses in COVID19 - a living review
25. T cell phenotypes in COVID-19 - a living review
26. Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells
27. Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose:glycoprotein glucosyl-transferase
28. Analysis of SARS-CoV-2 spike glycosylation reveals shedding of a vaccine candidate
29. Restricted processing of glycans by endomannosidase in mammalian cells
30. Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
31. Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections
32. Analysis of Free Oligosaccharides (fOS) from Wild-Type Saccharomyces cerevisiae (Baker's Yeast) using Two Different Extraction Methods
33. Clamping, Bending, and Twisting Inter-Domain Motions in the Misfold-Recognising Portion of UDP-Glucose: Glycoprotein Glucosyl-Transferase
34. Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose:glycoprotein glucosyl-transferase
35. Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology.
36. Mucosal immune responses in COVID19 - a living review.
37. T cell phenotypes in COVID-19 - a living review.
38. Structure of human endo-_-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
39. Minimal in vivo efficacy of iminosugars in a lethal Ebola virus guinea pig model
40. ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity
41. Iminosugar antivirals: the therapeutic sweet spot
42. Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model
43. Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes
44. Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis
45. Non-specific accumulation of glycosphingolipids in GNE myopathy
46. Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies
47. C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–l-isoDMDP Compared to Miglitol and Miglustat
48. Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays
49. Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase
50. Therapeutic Targets for Inhibitors of Glycosylation
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