Search

Your search keyword '"Altermatt, Anna"' showing total 23 results
Start Over Author "Altermatt, Anna"
23 results on '"Altermatt, Anna"'

1. Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Bhend, Katalin, Blum, Steffen, Bonati, Leo H., Carmine, Désirée, Conen, David, Eken, Ceylan, Fischer, Urs, Girroy, Corinne, Hennings, Elisa, Krisai, Philipp, Kühne, Michael, Mäder, Nina, Meyer-Zürn, Christine, Meyre, Pascal B., Monsch, Andreas U., Mosher, Luke, Müller, Christian, Osswald, Stefan, Paladini, Rebecca E., Peter, Raffaele, Schweigler, Adrian, Sticherling, Christian, Szucs, Thomas, Völlmin, Gian, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Netzer, Seraina, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Zarrabi Saffari, Tu Hanh, Rodondi, Nicolas, Reichlin, Tobias, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Murugiah, Samira, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Friedli, Corinne, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Caputo, Maria Luce, Peronaci, Rebecca, Regoli, Francois, Ronchi, Martina, Conte, Giulio, Brenner, Roman, Altmann, David, Fink, Karin, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Bühler, Kathrin, Justi, Virgina, Kellner-Weldon, Frauke, Koch, Melanie, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Kobza, Richard, Rigamonti, Elia, Cereda, Carlo, Cianfoni, Alessandro, De Perna, Maria Luisa, Frangi-Kultalahti, Jane, Mayer Melchiorre, Patrizia Assunta, Pin, Anica, Terrot, Tatiana, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Porretta, Alessandra Pia, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Aebersold, Helena, Foster, Fabienne, Schwenkglenks, Matthias, Düring, Marco, Sinnecker, Tim, Altermatt, Anna, Amann, Michael, Huber, Petra, Hürbin, Manuel, Ruberte, Esther, Thöni, Alain, Würfel, Jens, Zuber, Vanessa, Coslovsky (Head), Michael, Neuschwander, Pia, Simon, Patrick, Wunderlin, Olivia, Schmid, Ramun, Baumann, Christian, Hämmerle, Peter, Schlageter, Vincent, Coslovsky, Michael, Coduri, Federica, Blum, Manuel R., Stauber, Annina, Beer, Jürg, and Zuern, Christine S.

Published
2024
Full Text
View/download PDF

2. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Auberson, Chloé, Blum, Steffen, Bonati, Leo, Ceylan, Selinda, Conen, David, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Kühne, Michael, Meyer-Zürn, Christine, Meyre, Pascal, Monsch, Andreas U., Müller, Christian, Osswald, Stefan, Springer, Anne, Sticherling, Christian, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Rodondi, Nicolas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, Schmid, Ramun, Beer, Jürg H., Bonati, Leo H., Blum, Manuel R., Kastner, Peter, and Baguley, Fiona

Published
2021
Full Text
View/download PDF

6. A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression

Author

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, and Jun-ichi Kira

Subjects
Brain lesions, Brain volume, Disability, Magnetic resonance imaging, Multiple sclerosis, Progression, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background We compared the magnetic resonance imaging (MRI) features between Japanese and Caucasian patients with multiple sclerosis (MS), and identified the relationships between MRI features and disability. Methods From the baseline data of phase II fingolimod trials, 95 Japanese and 246 Caucasian relapsing-remitting MS patients were enrolled. The number, volume, and distribution of brain MRI lesions were evaluated using T2-weighted (T2W) images. Cross-sectional total normalized brain volume (NBV), normalized cortical gray matter volume, normalized deep gray matter volume (NDGMV), normalized white matter volume (NWMV), and normalized thalamic volume were measured. Results Japanese patients had significantly lower Expanded Disability Status Scale (EDSS) scores than Caucasian patients (mean 2.0 vs. 2.3, p = 0.008), despite a similar disease duration. Japanese patients showed a trend towards fewer T2W-lesions (median 50 vs. 65, p = 0.08) and significantly lower frequencies of cerebellar and parietal lobe lesions (p = 0.02 for both) than Caucasian patients. There were no differences in T2W-lesion volume between races, whereas Japanese patients had a significantly larger T2W-lesion volume per lesion compared with Caucasian patients (median 140 mm3 vs. 85 mm3, p

Published
2018
Full Text
View/download PDF

8. Right Hemispheric Predominance of Brain Infarcts in Atrial Fibrillation: A Lesion Mapping Analysis

Author

Altermatt, Anna, Sinnecker, Tim, Aeschbacher, Stefanie, Springer, Anne, Coslovsky, Michael, Beer, Juerg, Moschovitis, Giorgio, Auricchio, Angelo, Fischer, Urs, Aubert, Carole E, Kühne, Michael, Conen, David, Osswald, Stefan, Bonati, Leo H, Wuerfel, Jens, University of Zurich, and Bonati, Leo H

Subjects
11459 Center for Molecular Cardiology, 2728 Neurology (clinical), RC666-701, Diseases of the circulatory (Cardiovascular) system, 570 Life sciences, biology, 610 Medicine & health, Neurology (clinical), Cardiology and Cardiovascular Medicine, 2705 Cardiology and Cardiovascular Medicine
Published
2022
Full Text
View/download PDF

9. Sex differences of vascular brain lesions in patients with atrial fibrillation

Author

SWISS-AF Investigators, Ceylan, Selinda, Aeschbacher, Stefanie, Altermatt, Anna, Sinnecker, Tim, Rodondi, Nicolas, Blum, Manuel, Coslovsky, Michael, Evers-Dörpfeld, Simone, Niederberger, Sacha, Conen, David, Osswald, Stefan, Kühne, Michael, Düring, Marco, Wuerfel, Jens, Bonati, Leo, and Clinical sciences

Subjects
Male, Sex Characteristics, Cross-Sectional Studies, Humans, Female, Infarction/complications, Brain/diagnostic imaging, Cardiology and Cardiovascular Medicine, Atrial Fibrillation/complications
Abstract

OBJECTIVE: To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF). METHODS: In this cross-sectional analysis, we included 1743 patients with AF (27% women) from the multicentre Swiss Atrial Fibrillation study (SWISS-AF) with available baseline brain MRI. We compared presence and total volume of large non-cortical or cortical infarcts (LNCCIs), small non-cortical infarcts, microbleeds (MB) and white matter hyperintensities (WMH, Fazekas score ≥2 for moderate or severe degree) between men and women with multivariable logistic regression. We generated voxel-based probability maps to assess the anatomical distribution of lesions. RESULTS: We found no strong evidence for an association of female sex with the prevalence of all ischaemic infarcts (LNCCI and SNCI combined; adjusted OR 0.86, 95% CI 0.67 to 1.09, p=0.22), MB (adjusted OR 0.91, 95% CI 0.68 to 1.21, p=0.52) and moderate or severe WMH (adjusted OR 1.15, 95% CI 0.90 to 1.48, p=0.27). However, total WMH volume was 17% larger among women than men (multivariable adjusted multiplicative effect 1.17, 95% CI 1.01 to 1.35; p=0.04). Lesion probability maps showed a right hemispheric preponderance of ischaemic infarcts in both men and women, while WMH were distributed symmetrically. CONCLUSION: Women had higher white matter disease burden than men, while volume and prevalence of other lesions did not differ. Our findings highlight the importance of controlling risk factors for cerebral small vessel disease in patients with AF, especially among women.

Published
2022

10. Sex differences of vascular brain lesions in patients with atrial fibrillation

Author

Ceylan, Selinda, Aeschbacher, Stefanie, Altermatt, Anna, Sinnecker, Tim, Rodondi, Nicolas, Blum, Manuel, Coslovsky, Michael, Evers-Dörpfeld, Simone, Niederberger, Sacha, Conen, David, Osswald, Stefan, Kühne, Michael, Düring, Marco, Wuerfel, Jens, and Bonati, Leo

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

OBJECTIVE To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF). METHODS In this cross-sectional analysis, we included 1743 patients with AF (27% women) from the multicentre Swiss Atrial Fibrillation study (SWISS-AF) with available baseline brain MRI. We compared presence and total volume of large non-cortical or cortical infarcts (LNCCIs), small non-cortical infarcts, microbleeds (MB) and white matter hyperintensities (WMH, Fazekas score ≥2 for moderate or severe degree) between men and women with multivariable logistic regression. We generated voxel-based probability maps to assess the anatomical distribution of lesions. RESULTS We found no strong evidence for an association of female sex with the prevalence of all ischaemic infarcts (LNCCI and SNCI combined; adjusted OR 0.86, 95% CI 0.67 to 1.09, p=0.22), MB (adjusted OR 0.91, 95% CI 0.68 to 1.21, p=0.52) and moderate or severe WMH (adjusted OR 1.15, 95% CI 0.90 to 1.48, p=0.27). However, total WMH volume was 17% larger among women than men (multivariable adjusted multiplicative effect 1.17, 95% CI 1.01 to 1.35; p=0.04). Lesion probability maps showed a right hemispheric preponderance of ischaemic infarcts in both men and women, while WMH were distributed symmetrically. CONCLUSION Women had higher white matter disease burden than men, while volume and prevalence of other lesions did not differ. Our findings highlight the importance of controlling risk factors for cerebral small vessel disease in patients with AF, especially among women.

Published
2022
Full Text
View/download PDF

11. Sex differences of vascular brain lesions in patients with atrial fibrillation

Author

Ceylan, Selinda, primary, Aeschbacher, Stefanie, additional, Altermatt, Anna, additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Blum, Manuel, additional, Coslovsky, Michael, additional, Evers-Dörpfeld, Simone, additional, Niederberger, Sacha, additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Düring, Marco, additional, Wuerfel, Jens, additional, and Bonati, Leo, additional

Published
2022
Full Text
View/download PDF

12. Right Hemispheric Predominance of Brain Infarcts in Atrial Fibrillation: A Lesion Mapping Analysis [letter to the editor]

Author

Altermatt, Anna, Sinnecker, Tim, Aeschbacher, Stefanie, Springer, Anne, Coslovsky, Michael, Beer, Juerg, Moschovitis, Giorgio, Auricchio, Angelo, Fischer, Urs, Aubert, Carole E., K��hne, Michael, Conen, David, Osswald, Stefan, Bonati, Leo H, and Wuerfel, Jens

Subjects
360 Social problems & social services, 610 Medicine & health
Published
2022
Full Text
View/download PDF

13. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Blum, Steffen, primary, Aeschbacher, Stefanie, additional, Meyre, Pascal, additional, Kühne, Michael, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Bonati, Leo H., additional, Blum, Manuel R., additional, Kastner, Peter, additional, Baguley, Fiona, additional, Sticherling, Christian, additional, Osswald, Stefan, additional, Conen, David, additional, Auberson, Chloé, additional, Blum, Steffen, additional, Bonati, Leo, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Eken, Ceylan, additional, Girod, Marc, additional, Hämmerle, Peter, additional, Krisai, Philipp, additional, Meyer-Zürn, Christine, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Szucs, Thomas, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Loewe, Axel, additional, Moutzouri, Elisavet, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Müller, Andreas, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Beer, Jürg-Hans, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Hayoz, Daniel, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Kobza, Richard, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Vicari, Luisa, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Shah, Dipen, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Schläpfer, Jürg, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Stephan, Frank-Peter, additional, Gallino, Augusto, additional, Di Valentino, Marcello, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Würfel, Jens, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Sinnecker, Tim, additional, Zuber, Vanessa, additional, Coslovsky, Michael, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
Full Text
View/download PDF

14. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, primary, Blum, Steffen, additional, Meyre, Pascal B., additional, Coslovsky, Michael, additional, Vischer, Annina S., additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Moschovitis, Giorgio, additional, Moutzouri, Elisavet, additional, Hunkeler, Christof, additional, Burkard, Thilo, additional, Eken, Ceylan, additional, Roten, Laurent, additional, Zuern, Christine S., additional, Sticherling, Christian, additional, Wuerfel, Jens, additional, Bonati, Leo H., additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Auberson, Chloé, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Girod, Marc, additional, Hennings, Elisa, additional, Krisai, Philipp, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Voellmin, Gian, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Elodie Aubert, Carole, additional, Feller, Martin, additional, Loewe, Axel, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Müller, Andreas, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Moccetti, Tiziano, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Luce Caputo, Maria, additional, Regoli, Francois, additional, Ammann, Peter, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Hayoz, Daniel, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Kobza, Richard, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Shah, Dipen, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Schläpfer, Jürg, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Stephan, Frank-Peter, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Di Valentino, Marcello, additional, Gallino, Augusto, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Zuber, Vanessa, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Neuschwander, Pia, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
Full Text
View/download PDF

15. MSO906844 Supplemental Material - Supplemental material for White matter lesion location correlates with disability in relapsing multiple sclerosis

Author

Gaetano, Laura, Magnusson, Baldur, Kindalova, Petya, Tomic, Davorka, Silva, Diego, Altermatt, Anna, Magon, Stefano, Müller-Lenke, Nicole, Ernst-Wilhelm Radue, Leppert, David, Kappos, Ludwig, Wuerfel, Jens, Häring, Dieter A, and Sprenger, Till

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, MSO906844 Supplemental Material for White matter lesion location correlates with disability in relapsing multiple sclerosis by Laura Gaetano, Baldur Magnusson, Petya Kindalova, Davorka Tomic, Diego Silva, Anna Altermatt, Stefano Magon, Nicole Müller-Lenke, Ernst-Wilhelm Radue, David Leppert, Ludwig Kappos, Jens Wuerfel, Dieter A Häring and Till Sprenger in Multiple Sclerosis Journal—Experimental, Translational and Clinical

Published
2020
Full Text
View/download PDF

16. White matter lesion location correlates with disability in relapsing multiple sclerosis

Author

Gaetano, Laura, primary, Magnusson, Baldur, additional, Kindalova, Petya, additional, Tomic, Davorka, additional, Silva, Diego, additional, Altermatt, Anna, additional, Magon, Stefano, additional, Müller-Lenke, Nicole, additional, Radue, Ernst-Wilhelm, additional, Leppert, David, additional, Kappos, Ludwig, additional, Wuerfel, Jens, additional, Häring, Dieter A, additional, and Sprenger, Till, additional

Published
2020
Full Text
View/download PDF

17. A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression

Author

Ludwig Kappos, Ryo Yamasaki, Altermatt Anna, Takuya Matsushita, Lorena Bauer, Jens Wuerfel, Ernst Wilhelm Radue, Till Sprenger, Koji Shinoda, Laura Gaetano, Yuri Nakamura, Takahiko Saida, Jun Ichi Kira, Michael Amann, and Noriko Isobe

Subjects
0301 basic medicine, Male, Neurology, Gastroenterology, Severity of Illness Index, lcsh:RC346-429, Disability Evaluation, 0302 clinical medicine, Japan, Reference Values, Image Processing, Computer-Assisted, Brain volume, medicine.diagnostic_test, Progression, General Neuroscience, Brain, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Brain size, Disease Progression, Female, medicine.symptom, Adult, medicine.medical_specialty, Multiple Sclerosis, Race, Immunology, White People, White matter, Lesion, 03 medical and health sciences, Cellular and Molecular Neuroscience, Atrophy, Internal medicine, medicine, Humans, Disabled Persons, lcsh:Neurology. Diseases of the nervous system, Expanded Disability Status Scale, Disability, business.industry, Brain lesions, Multiple sclerosis, Research, Magnetic resonance imaging, medicine.disease, 030104 developmental biology, Cross-Sectional Studies, business, 030217 neurology & neurosurgery
Abstract

Background We compared the magnetic resonance imaging (MRI) features between Japanese and Caucasian patients with multiple sclerosis (MS), and identified the relationships between MRI features and disability. Methods From the baseline data of phase II fingolimod trials, 95 Japanese and 246 Caucasian relapsing-remitting MS patients were enrolled. The number, volume, and distribution of brain MRI lesions were evaluated using T2-weighted (T2W) images. Cross-sectional total normalized brain volume (NBV), normalized cortical gray matter volume, normalized deep gray matter volume (NDGMV), normalized white matter volume (NWMV), and normalized thalamic volume were measured. Results Japanese patients had significantly lower Expanded Disability Status Scale (EDSS) scores than Caucasian patients (mean 2.0 vs. 2.3, p = 0.008), despite a similar disease duration. Japanese patients showed a trend towards fewer T2W-lesions (median 50 vs. 65, p = 0.08) and significantly lower frequencies of cerebellar and parietal lobe lesions (p = 0.02 for both) than Caucasian patients. There were no differences in T2W-lesion volume between races, whereas Japanese patients had a significantly larger T2W-lesion volume per lesion compared with Caucasian patients (median 140 mm3 vs. 85 mm3, p

Published
2018

18. Damage of the lateral geniculate nucleus in MS

Author

Papadopoulou, Athina, primary, Gaetano, Laura, additional, Pfister, Armanda, additional, Altermatt, Anna, additional, Tsagkas, Charidimos, additional, Morency, Felix, additional, Brandt, Alexander U., additional, Hardmeier, Martin, additional, Chakravarty, Mallar M., additional, Descoteaux, Maxime, additional, Kappos, Ludwig, additional, Sprenger, Till, additional, and Magon, Stefano, additional

Published
2019
Full Text
View/download PDF

21. Design and construction of an innovative brain phantom prototype for MRI.

Author

Altermatt, Anna, Santini, Francesco, Deligianni, Xeni, Magon, Stefano, Sprenger, Till, Kappos, Ludwig, Cattin, Philippe, Wuerfel, Jens, and Gaetano, Laura

Abstract

Purpose: The purpose of this project was to construct a physical brain phantom for MRI, mimicking structure and T1 relaxation properties of white matter (WM) and gray matter (GM). Methods: The phantom design comprised 2 compartments, 1 resembling the WM and 1 resembling the GM. Their T1 relaxation times, as assessed using an inversion recovery turbo spin echo sequence, were reproduced using an agar gel doped with contrast agent (CA) and their folding patterns were simulated through a molding‐casting procedure using 3D‐printed casts and flexible silicone molds. Three versions of the assembling procedure were adopted to build: Phantom1 without any separation; Phantom2 with a varnish layer; and Phantom3 with a thin wax layer between the compartments. Results: Phantom1 was characterized by an immediate diffusion of CA between the 2 compartments. Phantom2 and Phantom3, instead, showed relaxation times and shape comparable with the target ones identified in a healthy control subject (WM: 754 ± 40 ms; GM: 1277 ± 96 ms). Moreover, both compartments revealed intact gyri and sulci. However, the diffusion of CA made Phantom2 stable only for a short period of time. Phantom3 showed stability within a time window of several days but the wax layer between the WM and GM was visible in the MRI. Conclusion: Structural and intensity properties of the constructed phantoms are useful in evaluating and validating steps from image acquisition to image processing. Moreover, the described constructing procedure and its modular design make it adjustable to a variety of applications. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

22. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, Chloé Auberson, Leo Bonati, Selinda Ceylan, Simone Doerpfeld, Ceylan Eken, Marc Girod, Peter Hämmerle, Philipp Krisai, Christine Meyer-Zürn, Andreas U. Monsch, Christian Müller, Anne Springer, Thomas Szucs, Gian Voellmin, Leon Zwimpfer, Drahomir Aujesky, Urs Fischer, Juerg Fuhrer, Laurent Roten, Simon Jung, Heinrich Mattle, Luise Adam, Carole Elodie Aubert, Martin Feller, Axel Loewe, Elisavet Moutzouri, Claudio Schneider, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Damiana Rakovic, Nathalie Schwab, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Andreas Müller, Simone Fontana, Silke Kuest, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Jürg-Hans Beer, Angelo Auricchio, Adriana Anesini, Cristina Camporini, Giulio Conte, Maria Luce Caputo, Francois Regoli, Tiziano Moccetti, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Daniel Hayoz, Benjamin Berte, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Sonja Meier, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Richard Kobza, Jane Frangi-Kultalahti, Anica Pin, Luisa Vicari, Georg Ehret, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Karl-Olof Lovblad, Patrick Perret, Philippe Tavel, Cheryl Teres, Dipen Shah, Nathalie Lauriers, Marie Méan, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Augusto Gallino, Marcello Di Valentino, Fabienne Witassek, Matthias Schwenkglenks, Jens Würfel, Anna Altermatt, Michael Amann, Petra Huber, Esther Ruberte, Tim Sinnecker, Vanessa Zuber, Michael Coslovsky, Pascal Benkert, Gilles Dutilh, Milica Markovic, Patrick Simon, Ramun Schmid, Clinical sciences, Auberson, Chloé, Bonati, Leo, Ceylan, Selinda, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Meyer-Zürn, Christine, Monsch, Andreas U., Müller, Christian, Springer, Anne, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, and Schmid, Ramun

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Epidemiology, Heart failure, 030204 cardiovascular system & hematology, ddc:616.0757, 03 medical and health sciences, 0302 clinical medicine, Insulin-Like Growth Factor Binding Proteins/blood, Physiology (medical), Internal medicine, Atrial Fibrillation, Clinical endpoint, Natriuretic peptide, medicine, Heart Failure/blood, Humans, 030212 general & internal medicine, cardiovascular diseases, Hospitalization/statistics & numerical data, Aged, Retrospective Studies, ddc:616, Heart Failure, Proportional hazards model, business.industry, Insulin-like growth factor-binding protein 7, Hazard ratio, Atrial fibrillation, Middle Aged, medicine.disease, Prognosis, Confidence interval, Hospitalization, Insulin-Like Growth Factor Binding Proteins, Atrial Fibrillation/blood, Cardiology, Disease Progression, Female, business, Cardiology and Cardiovascular Medicine, Biomarkers/blood, Biomarkers, Cohort study, Follow-Up Studies
Abstract

BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend

Published
2020

23. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal B., Coslovsky, Michael, Vischer, Annina S., Sinnecker, Tim, Rodondi, Nicolas, Beer, Jürg H., Moschovitis, Giorgio, Moutzouri, Elisavet, Hunkeler, Christof, Burkard, Thilo, Eken, Ceylan, Roten, Laurent, Zuern, Christine S., Sticherling, Christian, Wuerfel, Jens, Bonati, Leo H., Conen, David, Osswald, Stefan, Kühne, Michael, Swiss-AF Investigators, Auberson, Chloé, Ceylan, Selinda, Doerpfeld, Simone, Girod, Marc, Hennings, Elisa, Krisai, Philipp, Monsch, Andreas U., Müller, Christian, Springer, Anne, Voellmin, Gian, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Jung, Simon, Mattle, Heinrich, Adam, Luise, Elodie Aubert, Carole, Feller, Martin, Loewe, Axel, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Müller, Andreas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Moccetti, Tiziano, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Luce Caputo, Maria, Regoli, Francois, Ammann, Peter, Brenner, Roman, Altmann, David, Gemperle, Michaela, Hayoz, Daniel, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Kobza, Richard, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Frangi-Kultalahti, Jane, Pin, Anica, Shah, Dipen, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Schläpfer, Jürg, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Stephan, Frank-Peter, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Di Valentino, Marcello, Gallino, Augusto, Witassek, Fabienne, Schwenkglenks, Matthias, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Zuber, Vanessa, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Neuschwander, Pia, Simon, Patrick, and Schmid, Ramun

Subjects
Brain Infarction, Male, brain, ddc:616.0757, White Matter Lesions, Magnetic resonance imaging, Atrial Fibrillation, Humans, Aged, Aged, 80 and over, ddc:616, White matter, blood pressure, Brain, Original Articles, Middle Aged, Magnetic Resonance Imaging, White Matter, Atrial fibrillation, Cross-Sectional Studies, Hypertension, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Blood pressure, Female
Abstract

Supplemental Digital Content is available in the text., The association of blood pressure (BP) and hypertension with the presence of different types of brain lesions in patients with atrial fibrillation is unclear. BP values were obtained in a multicenter cohort of patients with atrial fibrillation. Systolic and diastolic BP was categorized in predefined groups. All patients underwent brain magnetic resonance imaging and neurocognitive testing. Brain lesions were classified as large noncortical or cortical infarcts, small noncortical infarcts, microbleeds, or white matter lesions. White matter lesions were graded according to the Fazekas scale. Overall, 1738 patients with atrial fibrillation were enrolled in this cross-sectional analysis (mean age, 73 years, 73% males). Mean BP was 135/79 mm Hg, and 67% of participants were taking BP-lowering treatment. White matter lesions Fazekas ≥2 were found in 54%, large noncortical or cortical infarcts in 22%, small noncortical infarcts in 21%, and microbleeds in 22% of patients, respectively. Compared with patients with systolic BP

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results