1. Renal plasma flow, filtration fraction and microalbuminuria in hypertensive patients: Effects of chronic smoking.
- Author
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ANDRONICO, GIUSEPPE, ROMÉ, MARIA, LO CICERO, ANTONINA, PARSI, RENATO, SEDDIO, GIOVANNA, FERRARO-MORTELLARO, ROSELLA, BUSCEMI, SILVIO, and CERASOLA, GIOVANNI
- Subjects
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HYPERTENSION , *PATIENTS , *CIGARETTE smokers , *ALBUMINS , *BLOOD flow , *BLOOD plasma , *BLOOD filtration - Abstract
Introduction: Albumin excretion rate is usually increased in people who smoke, but the physiological basis of this phenomenon is not fully understood. Methods: The effect of chronic smoking on renal haemodynamics was studied in a cohort of 66 men. Twenty-seven were smokers and 36 were hypertensive. In all subjects, the albumin excretion rate was evaluated; in hypertensive patients, a renoscintigraphic evaluation of renal plasma flow and glomerular filtration were carried out and the filtration fraction was calculated. Results: The hypertensive smoking population presented an increased urinary albumin excretion rate in comparison with hypertensive non-smoking patients. No significant differences were found for the mean values of renal plasma flow, the glomerular filtration rate and the filtration fraction between hypertensive smokers and hypertensive non-smoking patients. Conclusions: In hypertensive patients, smoking does not modify typical renal haemodynamic changes of arterial hypertension; however, it significantly increases the albumin excretion rate. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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