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1. The latest reports on androgenetic alopecia

Author

Anna Łopuszyńska and Łukasz Ochyra

Subjects
androgenetic alopecia, alopecia, dermatology, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract

Androgenetic alopecia (AGA) is the most common type of hair loss among women and men. AGA is caused by a combination of genetic factors resulting in sensitivity to dihydrotestosterone (DHT), which binds to the androgen receptor (AR), mediating a series of biomolecular changes that lead to changes in the hair. There are many mechanisms that can lead to AGA, some of which remain undiscovered. Treatment of AGA is also important for psychological reasons, as it constitutes a significant psychosocial stressor in the lives of people affected by this disease and worsens the quality of life. The only medications approved for the treatment of AGA are oral finasteride and topical minoxidil. These drugs may be associated with side effects, hence the need to look for other treatment methods, especially for patients who cannot tolerate approved methods. The current review focuses on the latest reports on the pathogenesis and treatment of androgenetic alopecia.

Published
2024
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2. Platelet-rich plasma in dermatology and aesthetic medicine

Author

Łukasz Ochyra and Anna Łopuszyńska

Subjects
aesthetic medicine, platelet-rich plasma, dermatology, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract

Introduction and purpose Aesthetic medicine is one of the youngest fields of medicine. Initially, it focused on improving the quality of life of patients by using various treatments aimed at stopping the aging process. Over time, this branch of medicine has developed dynamically, and nowadays the treatments focus not only on improving the appearance of the skin and its defects, but are also used to treat many dermatological problems. Platelet-rich plasma (PRP) is an autologous concentrate of platelets in a small volume of plasma. having numerous applications in many fields of medicine. The aim of this work is to present the method, focusing on its positive effects in the problems of aesthetic and regenerative medicine, as well as in some dermatological diseases. Material and methods The review was baised on the articles obtained from Pubmed and Google Scholar scientific databases from recent years using the keywords: aesthetic medicine, platelet-rich plasma, dermatology. Results The presence of numerous growth factors and other active ingredients makes the action of PRP comprehensive and based on several mechanisms. Studies show a positive effect, especially in skin rejuvenation and anti-aging prevention, hair reconstruction, wound healing and reconstruction of scars of various etiologies, as well as in pigmentation disorders. Moreover, combining PRP with other methods such as laser therapy or microneedling produces a synergistic effect, improving overall treatment results. Conclusions Platelet-rich plasma is an autologous preparation obtained after centrifugation of blood collected from the patient. The properties of PRP make it widely used in many clinical situations. is used both in aesthetic medicine and in dermatological problems. It should be emphasized that further multi-center studies are needed to standardize treatment protocols and adapt them to specific problems. Keywords: aesthetic medicine, platelet-rich plasma, dermatology.

Published
2024
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3. The use of stem cells in the treatment of diabetes mellitus and its complications - review

Author

Łukasz Ochyra and Anna Łopuszyńska

Subjects
diabetes mellitus, stem cells, diabetes complications, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction and purpose Diabetes is a disease resulting from impaired action or secretion of insulin. The number of patients currently amounts to approximately 422 million, and approximately 1.5 million deaths per year are directly attributed to this disease. Diabetes significantly reduces the quality of life and, if poorly controlled, can lead to serious complications. Mesenchymal stem cells are multipotent cells capable of differentiation. They have the ability to self-renew and have a modulating function. There are reports that they can be used in the treatment of this disease. The aim of the review was to present a new method of therapy and their possible effects. Material and methods The review was based on articles obtained from PubMed scientific database in the years 2015-2023, using the following keywords: diabetes mellitus, stem cells, diabetes complications. Results Implanted stem cells are able to transform into cells that produce and secrete insulin, and also enable better glycemic control. They can alleviate chronic inflammation and reduce fibrosis. Taking into account the complications that occur during long-term diabetes, the use of stem cells may be associated with improving the function of specific organs and tissues such as the kidneys, heart, eyes and nerves. Studies also report a positive effect of these cells on the healing process of wounds and ulcers. Conclusions Stem cells are a promising object of analysis. They can control glycemia and have a positive effect on the functioning of the kidneys, heart, eyes and nerves, and accelerate wound healing, but further, extensive research is needed to assess the effectiveness and safety of this therapy.

Published
2024
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4. CEUS in diagnosis of renal masses

Author

Łukasz Ochyra and Anna Łopuszyńska

Subjects
ultrasonography, cotrast enhanced ultrasonography, kidneys, renal masses, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction and purpose Contrast enhanced ultrasound (CEUS) is a modern diagnostic method that uses ultrasound waves in combination with intravenous administration of a contrast agent. It enables obtaining high resolution and assessing microcirculation in real time, thanks to which the researcher is able to analyze the enhancement and its features, which may help in diagnosing a specific pathology. Contrast agents, similar to CT and MRI, show specific phases of enhancement after administration - arterial, venous, delayed. Their additional advantage is safety, especially for patients with impaired kidney and thyroid function, and causing fewer allergic reactions. The aim of this review is to present the CEUS examination technique and the latest reports in the field of diagnosis of renal lesions. Material and methods This review was prepared based on the literature available from recent years in the PubMed and Google Scholar scientific databases using the keywords: ultrasonography, contrast enhanced ultrasonography, kidney, renal masses. Results Studies show that CEUS can be an effective method for imaging both cystic and solid lesions in the kidney. When using a contrast agent, the lesions show characteristic features that can guide the investigator to the diagnosis. Moreover, in comparative analyses, CEUS achieved comparable or better results than other diagnostic imaging methods. Conclusions CEUS is a modern and promising diagnostic method that can successfully compete with CT and MRI. Moreover, the metabolism and pharmacokinetics of contrast agents and their safety mean that CEUS can be used for the diagnosis of unclear pathologies in elderly patients, as well as for the control and supervision of changes that require frequent imaging. Keywords: ultrasonography, contrast enhanced ultrasonography, kidneys, renal masses

Published
2024
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5. Diet and its association with reduced semen quality

Author

Łukasz Ochyra, Anna Łopuszyńska, Mateusz Pawlicki, and Halina Piecewicz-Szczęsna

Subjects
diet, semen, infertility, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Infertility is defined as the inability to conceive a child for at least 12 months of regular unprotected intercourse and may affect up to 15% of couples of reproductive age. Reduced semen quality may be caused by trauma, inflammation, or an inappropriate lifestyle. Research suggests that diet may be a factor in influencing sperm parameters. Material and methods: The literature of the PubMed scientific base was searched in 2015-2022 using the following keywords: semen, diet, infertility. Results: Analyzes of eating patterns showed that eating a diet high in red meat, high-fat dairy, sweet energy drinks, and snacks could negatively affect semen, and a pattern based on the consumption of fish, chicken, vegetables, fruits, legumes, and whole grains was associated with with an increased concentration of sperm. A high-fat diet (HFD) leads to obesity, endocrine disorders, dysbiosis of the intestinal microflora, and may be a factor that activates autophagy, which results in reduced sperm quality. A ketogenic diet can positively affect the semen of obese, infertile men. Studies analyzing the Mediterranean diet suggest that higher compliance rates are associated with a higher percentage of mobility as well as a reduced risk of low sperm concentration. The way you prepare your meals can also play a role as glycation end products are produced when grilling, baking and frying, which can damage sperm DNA. Conclusions: Diet may be an important factor influencing the quality of sperm in men, however, there is a need for further extensive, multi-center studies that will systematize this knowledge, which will enable the creation of specific nutritional recommendations for this group of people.

Published
2022
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6. Neurological manifestations and complications of COVID-19. A literature review

Author

Aleksandra Maria Krasa, Magdalena Kozioł, Halina Piecewicz-Szczęsna, Anna Łopuszyńska, Ewa Piekarska, Piotr Więsyk, and Mateusz Pawlicki

Subjects
covid-19, sars-cov-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction. The first case of SARS-CoV-2 infection was identified in December 2019 in Wuhan, China. The disease spread rapidly worldwide and the WHO declared a pandemic on March 11, 2020. Although coronavirus disease 2019 (COVID-19) has been associated primarily with respiratory disorders, more and more research is focusing on neurological manifestations and complications.Objective. The aim of the review is to systematize and update the knowledge and available research on neurological complications among COVID-19 patients.Review methods. A systematic search of PubMed and Google Scholar databases was conducted for studies. The following keywords combinations were used: COVID-19, SARS-CoV-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence.Results. The disease in most patients is characterized by mild to medium fever, fatigue, dry cough, dyspnea, muscle pain and headache. ACE2, which is the receptor for SARS-COV-2, is ubiquitously expressed in a variety of human organs, including the brain. Following previous reports, these receptors are expressed in both glial cells and neurons. Many studies have reported neurological symptoms and complications among COVID-19 patients. The reported manifestations include: smell and taste disturbance, non-specific symptoms such as myalgia, headache and dizziness, acute cerebrovascular complications, encephalopathy, meningoencephalitis/encephalitis, seizure and complications of the peripheral nervous system.Conclusion. Healthcare professionals dealing with COVID-19, neuroscientists, and the general public should be aware of the neurological complications of COVID-19. Further studies are needed to assess the incidence of COVID-19 neurological complications in different populations and more analyzes are also required to understand the detailed mechanism of how the virus affects the nervous system.

Published
2021
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7. Caffeine in Pain Perception and Management

Author

Ewa Piekarska, Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Aleksandra Krasa, and Halina Piecewicz-Szczęsna

Subjects
affeine, pain, analgesia, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Caffeine is considered to be one of the most frequently used pharmacologically active substances in the world. Caffeine is a psychoactive and central nervous system stimuli that has the ability to increase energy, decrease fatigue, promote alertness and wakefulness. Potential role of caffeine's nociceptive properties shows that it may play a relevant role in pain modulation. Although caffeine at dietary levels is not a sufficient analgesic in its own, it has been included in many over-the-counter and prescription drugs. This review addresses caffeine's analgesic properties in pain management. Results: Caffeine shows relevant role in pain modulation through blocking adenosine receptors which are involved in nociception. Studies show that habitual dietary caffeine consumption results in decreased pain sensitivity.As an adjuvant to commonly used analgesics, caffeine provides an important increase in pain relief in various types of pain such as postoperative dental pain, headaches, or fibromyalgia.Conclusions: In conclusion, caffeine is associated with decreased pain sensitivity. Addition of caffeine to analgesics has resulted in their enhanced analgesic efficacy in pain treatment.

Published
2021
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8. Association Between Male fertility and Vitamin D

Author

Ewa Piekarska, Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Aleksandra Krasa, and Halina Piecewicz-Szczęsna

Subjects
vitamin d, male fertility, infertility, male reproductive system, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Infertility affects millions of people of reproductive age worldwide. Male infertility may be caused by a number of different factors including problems in the ejection of semen, absence or low levels of sperm, or abnormal morphology and movement of the sperm. Environmental and lifestyle factors also have a meaningful impact on male reproductive system. Fertility care should include the prevention, diagnosis and treatment of the disorder. That is why numerous studies have explored the role of vitamin D in regulating the functioning of the reproductive system.Aim of study: Investigation of correlation between Vitamin D and male fertility.Results: Studies consistently show that Vitamin D deficiency has a negative influence on male fertility. Number of trials show that the mean value of Vitamin D serum levels tend to be significantly lower in infertile men compared to fertile men. Vitamin D insufficiency and deficiency has been noticed to be associated with poor semen quality (lower sperm concentrations, lower motility). It became evident that vitamin D exhibits positive correlation with the male fertility by maintaining the levels of sex hormones, down regulating oxidative stress and up regulating oxidative defence. Supplementation of Vitamin D may improve the quality and function of sperm by increasing its motility and concentration.Conclusions: Although Vitamin D supplementation cannot be considered for treatment of male infertility itself, physicians should take the vitamin serum levels under consideration while providing treatment for infertile male patients.

Published
2021
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9. Berberine in the treatment of polycystic ovary syndrome

Author

Łukasz Ochyra, Anna Łopuszyńska, Mateusz Pawlicki, and Halina Piecewicz-Szczęsna

Subjects
berberine, polycystic ovary syndrome, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a hormonal disorder most common in women in reproductive age. The global incidence varies from 6% to 20% depending on the diagnostic criteria used, and is also the most common cause of infertility. This disease is related to insulin resistance and hyperinsulinemia. Berberine is a compound that affects the cardiovascular system and carbohydrate metabolism, which is why there are attempts to introduce it into the therapy of patients with PCOS. Material and methods: The literature was reviewed in the PubMed scientific base in the years 2012-2022 using the following keywords: berberine, polycystic ovary syndrome. Results: Research show that the use of berberine may have a positive effect on the waist circumference and waist-to-hip ratio, improve lipid parameters, lower the concentration of androgens, and reduce insulin resistance. In addition, a promising effect is the stabilization of the menstrual cycle and improvement of ovulation. There are reports that this drug may also restore the normal composition of the intestinal microflora disrupted in PCOS. Side effects are rare and mild, which confirms the safety of this substance. Conclusions: Polycystic ovary syndrome affects many women, leading to numerous and serious side effects, so it is important to develop an effective treatment with as few side effects as possible. Berberine is a promising prospect, but more studies are needed on larger groups of patients to confirm these reports and develop an effective treatment regimen. Keywords: berberine, polycystic ovary syndrome.

Published
2022
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10. Endometriosis and an increased risk of malignancies

Author

Aleksandra Maria Krasa, Magdalena Kozioł, Halina Piecewicz-Szczęsna, Mateusz Pawlicki, Anna Łopuszyńska, Paulina Krawiec, and Ewa Piekarska

Subjects
endometriosis, cancer risk, ovarian cancer, non‐gynecological cancers, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Endometriosis is a common gynaecological disorder associated with pelvic pain and sub-fertility, affecting 7–15% of women of reproductive age. The disease is defined as the presence of endometrial-like tissue outside the uterine cavity, primarily on pelvic organs. The aetiology of endometriosis is still uncertain. The disease rarely causes mortality, however, it may have a significant impact on a patient's quality of life. Moreover, several studies have consistently shown that endometriosis is associated with a higher risk of some types of malignancies.Results: Endometriosis shares several molecular characteristics with invasive cancer, such as inflammation, tissue invasion, angiogenesis, dysfunction of immune cells and pro-survival features. Studies have shown that ovarian cancer, especially clear cell, endometrioid and serous, has been associated with endometriosis. Furthermore, the risk of cancer of the uterine cervix has shown to be decreased and the results on the risk of the cancers of uterine corpus or breast are inconsistent. Among non‐gynecological cancers, melanoma of the skin, non‐Hodgkin‐lymphoma, brain and thyroid cancers have also been associated with endometriosis.Conclusions: Research results indicate that women with endometriosis have an increased risk for some types of malignancies, therefore, they should be under strict gynecological control, even many years after menopause. Further research is needed to prove the real risk of different types of malignant tumors among women with endometriosis. In addition, it is necessary to establish periodic examination schedules among these patients in order to prevent certain types of malignancies.

Published
2020
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11. Sleep disorders in patients with neoplasm

Author

Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Aleksandra Krasa, Ewa Piekarska, and Halina Piecewicz-Szczęsna

Subjects
cancer, neoplasm, sleep, insomnia, sleep disoders, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Sleep disorders are a big group of disturbances affecting many people in the world. They can appear as insomnia, interrupted sleep, worsened sleep quality or trouble falling asleep. Although they may not seem very dangerous, they lead to various unpleasant complications and even diseases. Cancer is said to be one of the possible sources of the problem.Results: Studies show relationship between cancer and sleep disruptions. They are frequent in lung, head and neck, gynecologic and breast neoplasms. Patients report higher scores of Pittsburgh Sleep Quality Index, insomnia severity scale and Epworth Sleepiness Scale meaning that they can be considered as poor sleepers. In addition, they often develop psychiatric disorders which are linked with higher risk of sleep problems.Conclusions: According to many research, cancer often comes with somnipathies. It should be taken into consideration when planning oncologic treatment and care to obtain the best effects of the therapy.

Published
2020
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12. The analysis of a wide spectrum of activity of Sodium-Glucose co-transporter-2 inhibitors. A literature review

Author

Magdalena Kozioł, Danuta Krasowska, Marcin Lewicki, Mateusz Pawlicki, Anna Łopuszyńska, Aleksandra Krasa, and Ewa Piekarska

Subjects
sodium-glucose co-transporter-2 (sglt2) inhibitors, obesity, weight loss, mechanisms, kidney., Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: The discovery of sodium-glucose co-transporter-2 inhibitors is attributed to phlorizin, which after oral administration caused the excretion of glucose in urine. Later studies showed that this effect was conditioned by SGLT-2 inhibition. However, this substance has not been used in the treatment of diabetes mellitus due to its non-selective action. Beeing also active against SGLT-1 transporters in alimentary tract, it causes osmotic diarrhea, dehydration and eventually malnutrition. Currently in Poland, gliflozins are used only in the treatment of diabetes mellitus, mainly type 2, especially with coexisting obesity and high cardio-vascular risk. However, as many human and animal studies show, the effect of SGLT2 inhibitors can be observed in many systems and organs.Results: The best known non-anti-diabetic action is the reduction of body fat and protection against fat accumulation following a high-calorie diet. These compounds reduce the production of endogenous fatty acids. Moreover, gliflozines lower the levels of cholesterol, triglycerides, uric acid and aminotransferases. They have a protective effect on the liver because they cause remission of nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD). They lower the cardiovascular risk and have an anti-inflammatory effect. Moreover, they inhibit vascular remodeling and improve hemodynamic conditions.Conclusions: According to many research, gliflozines have many collateral effects which can be used in the clinic as a treatment of diseases other than diabetes or coexisting with it. Obesity and cardiovascular diseases are among the most important health problems in the modern world. SGLT-2 inhibitors can prevent the above-mentioned diseases and reduce them.

Published
2020
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13. A rare case of Raoultella planticola urinary tract infection. A case report with literature review

Author

Magdalena Kozioł, Marcin Lewicki, Mateusz Pawlicki, Anna Łopuszyńska, Aleksandra Krasa, Ewa Piekarska, and Danuta Krasowska

Subjects
raoultella planticola, urine infections, resistance., Education, Sports, GV557-1198.995, Medicine
Abstract

Urine infections represent 40-50% of all infections in hospitalized patients. The most common uropathogens are E.coli, S.saprophitycus, and less commonly Enterobacteriaceae, such as Proteus mirabilis and Klebsiella pneumoniae. The spectrum of microorganisms isolated in hospital conditions may be wider. Raoultella planticola is a rare cause of human infections, so far only few cases of ZUM with this etiology have been described.A 56-years-old patient, with a history of cardiac disease, with exacerbation of chronic kidney disease, was admitted to the Department of Internal Medicine. The reason for admission was general deterioration. Many abnormalities in laboratory tests were detected. The doctors' attention was focused on the significant bacteriuria. Moreover, the patient reported dysuria symptoms. Material for urine microbiological culture was taken and empirical antibiotic therapy with ciprofloxacin started. The obtained result of urine culture allowed to identify the bacteria by R. planticola. As a result of the applied treatment, the patient's condition improved.An increasing number of infections with R. planticolla etiology is observed. The bacterium may lead to infections in many systems. The group of patients at risk of the disease includes people with renal dysfunction, who are immunosuppressed. Infections of R. planticolla etiology are usually characterized by good antibiotic response and positive prognosis.

Published
2020
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14. Acne vulgaris and mental health

Author

Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Aleksandra Krasa, Ewa Piekarska, and Halina Piecewicz-Szczęsna

Subjects
acne, mental health, depression, anxiety, suicide, quality of life, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Acne vulgaris is one of the most common diseases in the world, which affects millions of people. Despite its objectively mild clinical severity, it is able to markedly change one’s appearance. Moreover it is said to be one of many factors that are responsible for mental health impairments. Results: Studies showed significant relation between acne and psychological disorders. Both depression and anxiety scores were higher in individuals with acne compared to healthy ones. Some studies reported an increased risk of suicide in this group as well. Research which included quality of life evaluation showed its impairment in larger part of respondents. Conclusions: Acne vulgaris is linked with an increased risk of serious psychiatric disorders. Therefore it is important to think about them when this condition is diagnosed.

Published
2021
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15. The role of diet in development of acne vulgaris

Author

Mateusz Pawlicki, Bartłomiej Pawlicki, Anna Łopuszyńska, Zofia Misztal, Karol Lorenc, and Magdalena Kozioł

Subjects
acne, acne vulgaris, diet, Education, Sports, GV557-1198.995, Medicine
Abstract

Acne is one of the most widely spread dermatoses in the world mainly among adolescents and young adults. Because of its problematic symptoms it is very willingly treated with diverse available drugs. Despite its popularity, there is still lack of precise information about this disease. Even though risk factors like infections or hormonal changes are said to be well known, medicine is still not certain about some of them. Diet is one of the examples. It is supposed to play a huge role in acne genesis. Considering the ease of diet modifications it is crucial to understand its participation.

Published
2019
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16. Ketogenic diet in pediatric patients with epilepsy

Author

Bartłomiej Pawlicki, Zofia Maria Misztal, Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Karol Lorenc, and Damian Bator

Subjects
ketogenic diet, pediatric, epilepsy, Education, Sports, GV557-1198.995, Medicine
Abstract

Ketogenic diet (KD) is a version of low-carbohydrate diet, that is rich in fat, but also contains enough protein and very low carbohydrates supply. This diet may be one of the treatment option for children with refractory epilepsy and studies show that it reduces seizures. KD may affect behavioural and cognitive functioning in children and adolescents with refractory epilepsy. The main weakness of KD are possible adverse side effects included drowsiness, constipation, weight loss, vomiting, gastroesophageal reflux, fever, hyperlipidaemia and elevated risk of kidney stones development.

Published
2019
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17. Cefiderocol - a promising new antibiotic for the antibiotic-resistant pathogens of the highest epidemiological priority

Author

Karol Lorenc Lorenc, Magdalena Kozioł, Alicja Sobek, Mateusz Pawlicki, Anna Łopuszyńska, Zofia Misztal, Marcin Lewicki, and Agata Smoleń

Subjects
cefiderocol, cephalosporin, antibiotic resistance, Education, Sports, GV557-1198.995, Medicine
Abstract

Increase in the incidence of multidrug-resistant Gram-negative bacterial strains pose a significant threat to healthcare system worldwide. New antibiotics are necessary to combat particularly resitant pathogens. WHO’s global priority pathogens list was published in 2017 to promote research and development of new antibiotics, as part of WHO’s efforts to address growing global resistance to antimicrobial agents. Acinetobacter baumannii, Pseudomonas aeruginosa and carbapenem-resistant, third-generation cephalosporin-resistant Enterobacteriaceae were classified as highest priority pathogens requiring a new antibiotic treatment options. Cefiderocol is a novel parenteral siderophore cephalosporin that shows efficacy against listed Gram-negative bacteria. The results of the presented studies showed that cefiderocol has a strong antimicrobial effect against problematic strains that produce carbapenemases, such as KPC (K. pneumoniae carbapenemase) and B-class metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase), as well as the ESBL-producing strains. In addition, it does not require the use of the β-lactamase inhibitor. The new agent demonstrates a favorable side effect profile. There is an urgent need to develop new antibiotics. Cefiderocol is a new antibiotic that has a potential to effectively combat particularly resistant bacteries such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, as well as carbapenem and 3rd generation cephalosporin-resistant Enterobacteriaceae.

Published
2019
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18. Communication in pediatric oncology

Author

Anna Łopuszyńska, Łukasz Ochyra, Mateusz Pawlicki, and Irena Karwat

Subjects
communication, pediatric, oncology, Education, Sports, GV557-1198.995, Medicine
Abstract

Introduction: Neoplasms are the second most frequent cause of death in the pediatric population. In Poland, approximately 1100-1200 new cases of malignant neoplasms are diagnosed annually. Communication is an extremely important factor in pediatric oncology care. Hence, more and more research on its functions, significance, but also barriers and limitations is being developed. Material, methods, purpose: The literature published in the PubMed scientific database was searched using the following keywords: communication, pediatrics, oncology in 2016-2022. The aim of this review is to show the barriers, functions, and the importance of communication in pediatric oncology for the therapeutic process. Results: Communication in pediatric oncology was shown to perform the following functions: building relationships, exchanging information, enabling the family to self-manage, making decisions, managing uncertainty, responding to emotions, providing validation, and supporting hope. It was also noted that high-quality communication is associated with parental peace, increased recognition and confidence in healthcare professionals. Parents who receive understandable prognostic information have found less regret, as well as a desire to maximize time spent together with their child. Research shows communication barriers on many levels, such as: lack of comfort in difficult topics, time pressure, or the lack of a common mental model of the team and excessive demands. However, knowing these limitations is crucial to improving and overcoming these barriers. Conclusions: Communication in pediatric oncology plays many fundamental roles and constitutes an important aspect of the therapeutic process. Accordingly, it is important to emphasize the development and improvement of healthcare professionals' communication skills. Doctors can use knowledge of communication functions to better understand and fulfill parents' communication needs.

Published
2011
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19. The influence of diet on polycystic ovary syndrome

Author

Halina Piecewicz-Szczęsna, Magdalena Kozioł, Aleksandra Krasa, Ewa Piekarska, Anna Łopuszyńska, and Mateusz Pawlicki

Subjects
Vitamin, medicine.medical_specialty, business.industry, Dietary control, Reproductive medicine, Physiology, Disease, Affect (psychology), Polycystic ovary, Education, First line treatment, bmi, chemistry.chemical_compound, chemistry, GV557-1198.995, Vitamin D and neurology, Medicine, policystic ovary syndrome, business, diet, Sports
Abstract

ŁopuszyńskaAnna,PawlickiMateusz,KozioMagdalenał,KrasaAleksandra,PiekarskaEwa,Piecewicz-SzczęsnaHalina. The influence of diet on polycystic ovary syndrome.Journal of Education, Healthand Sport. 2021;11(9):131-136. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.018 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.018 https://zenodo.org/record/5485007 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2021. Revised: 26.08.2021. Accepted: 07.09.2021. The influence of diet on polycystic ovary syndrome Anna Łopuszyńska1, Mateusz Pawlicki1, Magdalena Kozioł1, Aleksandra Krasa1, Ewa Piekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńskahttps://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Mateusz Pawlickihttps://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Magdalena Koziołhttps://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasahttps://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarskahttps://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Dr n. med. Halina Piecewicz-Szczęsnahttps://orcid.org/0000-0002-0573-7226, halpiec@gmail.com Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women inreproductive age. It is estimated that it affects about 5-10% of women aged 18-44. This disease is associated with reproductive dysfunction and metabolic disorders. According to the American Society for Reproductive Medicine (ASRM) 2018 guidelines, the first line treatment for PCOS are lifestyle adjustments, including dietary control and exercise. Hence a lot of research on the diet that is most appropriate for this group of people. Material and methods: PubMed research base was searched using the following keywords: diet, pcos, policystic ovary syndrome in 2017-2021. Results: The diet of women with PCOS is poorly composed,and dietary errors may affect the metabolic disorders occurring in these patients. Women with PCOS tend to have insufficient intakes of vitamin D, fiber, and vitamin B9, as well as excessive sodium intake. Mediterranean, ketogenic, low-carbohydrate, low-glycemic, low-AGE and pod-based diets positively affect this disease in variousways. Conclusions: PCOS is a very diverse disease that affects a large number of women around the world. Changing your lifestyle, including diet and exercise, is the first line treatment. This is why creating the best diet for these patients is extremely important. Current discoveries are very promising and give hope to create a model of nutrition that will be the best for these women. Large, multicentre randomized trials are still needed to develop diets that are appropriate for different patients because the disease picture is heterogeneous. Keywords: diet, policystic ovary syndrome, bmi

Published
2021

20. Caffeine in Pain Perception and Management

Author

Aleksandra Krasa, Magdalena Kozioł, Mateusz Pawlicki, Halina Piecewicz-Szczęsna, Ewa Piekarska, and Anna Łopuszyńska

Subjects
business.industry, Analgesic, analgesia, medicine.disease, Adenosine receptor, Education, chemistry.chemical_compound, Alertness, Nociception, chemistry, Fibromyalgia, Anesthesia, GV557-1198.995, medicine, Medicine, pain, Wakefulness, affeine, Headaches, medicine.symptom, Caffeine, business, Sports
Abstract

Piekarska Ewa, Pawlicki Mateusz, Łopuszyńska Anna, Kozioł Magdalena, Krasa Aleksandra, Piecewicz-Szczęsna Halina. Caffeine in Pain Perception and Management. Journal of Education, Health and Sport. 2021;11(8):328-333. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.08.036 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.08.036 https://zenodo.org/record/5274050 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.08.2021. Revised: 15.08.2021. Accepted: 26.08.2021. Caffeine in Pain Perception and Management Ewa Piekarska1, Mateusz Pawlicki1, Anna Łopuszyńska1, Magdalena Kozioł1, Aleksandra Krasa1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Ewa Piekarska, piekarskaewaa@gmail.com ORCID ID: Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Mateusz Pawlicki https//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Abstract: Introduction: Caffeine is considered to be one of the most frequently used pharmacologically active substances in the world. Caffeine is a psychoactive and central nervous system stimuli that has the ability to increase energy, decrease fatigue, promote alertness and wakefulness. Potential role of caffeine's nociceptive properties shows that it may play a relevant role in pain modulation. Although caffeine at dietary levels is not a sufficient analgesic in its own, it has been included in many over-the-counter and prescription drugs. This review addresses caffeine's analgesic properties in pain management. Results: Caffeine shows relevant role in pain modulation through blocking adenosine receptors which are involved in nociception. Studies show that habitual dietary caffeine consumption results in decreased pain sensitivity. As an adjuvant to commonly used analgesics, caffeine provides an important increase in pain relief in various types of pain such as postoperative dental pain, headaches, or fibromyalgia. Conclusions: In conclusion, caffeine is associated with decreased pain sensitivity. Addition of caffeine to analgesics has resulted in their enhanced analgesic efficacy in pain treatment. Key words: caffeine; pain; analgesia

Published
2021

21. Communication in pediatric oncology

Author

Anna Łopuszyńska, Łukasz Ochyra, Mateusz Pawlicki, and Irena Karwat

Subjects
General Medicine
Abstract

Ochyra, Łukasz, Łopuszyńska, Anna, Pawlicki, Mateusz, Karwat, Irena.Communication in pediatric oncology. Journal of Education, Health and Sport. 2022;12(4):315-320.eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.04.025 https://apcz.umk.pl/JEHS/article/view/40132 https://zenodo.org/record/7117601 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 23.03.2022. Revised: 06.04.2022. Accepted: 30.04.2022. Communication in pediatric oncology Anna Łopuszyńska (1), Łukasz Ochyra (1), Mateusz Pawlicki (1), Irena Dorota Karwat (2) Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Medical Institute, State University of Jan Grodek in Sanok, ul Mickiewicza 21, Sanok 38-500, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Łukasz Ochyra https://orcid.org/0000-0002-8586-3619, lukaszochyra98@gmail.com Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Irena Dorota Karwathttps://orcid.org/0000-0001-9132-6062,irbisiza10@wp.pl Abstract: Introduction: Neoplasms are the second most frequent cause of death in the pediatric population. In Poland, approximately 1100-1200 new cases of malignant neoplasms are diagnosed annually. Communication is an extremely important factor in pediatric oncology care. Hence, more and more research on its functions, significance, but also barriers and limitations is being developed. Material, methods, purpose: The literature published in the PubMed scientific database was searched using the following keywords: communication, pediatrics, oncology in 2016-2022. The aim of this review is to show the barriers, functions, and the importance of communication in pediatric oncology for the therapeutic process. Results: Communication in pediatric oncology was shown to perform the following functions: building relationships, exchanging information, enabling the family to self-manage, making decisions, managing uncertainty, responding to emotions, providing validation, and supporting hope. The last two functions have not been found previously in adult oncology. It was also noted that high-quality communication is associated with parental peace, increased recognition and confidence in healthcare professionals. Parents who receive understandable prognostic information have found less regret, as well as a desire to maximize time spent together with their child. Moreover, children who participated in the discussions about the disease had less anxiety and greater acceptance of their disease. Research shows communication barriers on many levels, such as: lack of comfort in difficult topics, time pressure, or the lack of a common mental model of the team and excessive demands. However, knowing these limitations is crucial to improving and overcoming these barriers. Conclusions: Communication in pediatric oncology plays many fundamental roles and constitutes an important aspect of the therapeutic process. Accordingly, it is important to emphasize the development and improvement of healthcare professionals' communication skills. Doctors can use knowledge of communication functions to better understand and fulfill parents' communication needs. Future work should focus on measuring whether clinical teams are fulfilling these functions and developing communication interventions to address these functions. Keywords: communication, paediatrics, oncology

Published
2022

22. Sleep disorders in patients with neoplasm

Author

Magdalena Kozioł, Aleksandra Krasa, Halina Piecewicz-Szczęsna, Ewa Piekarska, Mateusz Pawlicki, and Anna Łopuszyńska

Subjects
medicine.medical_specialty, insomnia, Education, Pittsburgh Sleep Quality Index, Insomnia, cancer, Medicine, In patient, sleep, Intensive care medicine, Sleep quality, business.industry, Epworth Sleepiness Scale, Cancer, medicine.disease, Sleep in non-human animals, sleep disoders, Trouble falling asleep, GV557-1198.995, medicine.symptom, business, neoplasm, Sports
Abstract

Pawlicki Mateusz, Łopuszyńska Anna, Kozioł Magdalena, Krasa Aleksandra, Piekarska Ewa, Piecewicz-Szczęsna Halina. Sleep disorders in patients with neoplasm. Journal of Education, Health and Sport. 2020;10(9):514‑519. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.09.062 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.09.062 https://zenodo.org/record/4042199 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 16.09.2020. Revised: 21.09.2020. Accepted: 22.09.2020. Sleep disorders in patients with neoplasm Mateusz Pawlicki1, Anna Łopuszyńska1, Magdalena Kozioł1, Aleksandra Krasa1, EwaPiekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Mateusz Pawlicki, pawlak32@gmail.com ORCID ID: Mateusz Pawlicki https//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract: Introduction: Sleep disorders are a big group of disturbances affecting many people in the world. They can appear as insomnia, interrupted sleep, worsened sleep quality or trouble falling asleep. Although they may not seem very dangerous, they lead to various unpleasant complications and even diseases. Cancer is said to be one of the possible sources of the problem. Results: Studies show relationship between cancer and sleep disruptions. They are frequent in lung, head and neck, gynecologic and breast neoplasms. Patients report higher scores of Pittsburgh Sleep Quality Index, insomnia severity scale and Epworth Sleepiness Scale meaning that they can be considered as poor sleepers. In addition, they often develop psychiatric disorders which are linked with higher risk of sleep problems. Conclusions: According to many research, cancer often comes with somnipathies. It should be taken into consideration when planning oncologic treatment and care to obtain the best effects of the therapy. Key words: cancer, neoplasm, sleep, insomnia, sleep disorders

Published
2020

23. Methods of contraception for men

Author

Magdalena Kozioł, Anna Łopuszyńska, Halina Piecewicz-Szczęsna, Aleksandra Krasa, Ewa Piekarska, and Mateusz Pawlicki

Subjects
fertility, medicine.medical_specialty, male contraception, Obstetrics, business.industry, media_common.quotation_subject, Vasectomy, Fertility, Testosterone (patch), Abortion, Education, GV557-1198.995, medicine, Adjudin, Medicine, reproductive health, business, Male condoms, media_common, Reproductive health, Pregnancy prevention, Sports
Abstract

Łopuszyńska Anna, Pawlicki Mateusz, Piekarska Ewa, Kozioł Magdalena, Krasa Aleksandra, Piecewicz-Szczęsna Halina. Methods of contraception for men. Journal of Education, Health and Sport. 2020;10(9):284‑289. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.09.032 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.09.032 https://zenodo.org/record/4026076 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.08.2020. Revised: 25.08.2020. Accepted: 12.09.2020. Methods of contraception for men Anna Łopuszyńska1, Mateusz Pawlicki1, Ewa Piekarska1, Magdalena Kozioł1, Aleksandra Krasa1, Halina Piecewicz-Szczęsna2 1 Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; 2 Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract Many pregnancies in the world are unintentional and some of them end in abortion, hence there is a great need and amount of research on contraceptives. There are many methods of pregnancy prevention for women. However, men also want to be responsible for their reproductive health. Currently, there are few methods of contraception for men (male condoms, vasectomy, withdrawal) and they have their drawbacks, so research on new contraceptives for men is ongoing. Hormonal methods under research include testosterone, nestorone, and DMAU. On the other hand, adjudin, WIN 18.446, BMS-189453 and RISUG are promising methods of non-hormonal male contraception. These substances can be a discovery and a breakthrough in male contraception, they will allow men to better control their fertility and reproductive health, and can also be a suitable solution for couples in which there are contraindications for women to use contraception. Key words: fertility; reproductive health; male contraception.

Published
2020

24. A rare case of Raoultella planticola urinary tract infection. A case report with literature review

Author

Aleksandra Krasa, Marcin Lewicki, Ewa Piekarska, Magdalena Kozioł, Danuta Krasowska, Anna Łopuszyńska, and Mateusz Pawlicki

Subjects
medicine.medical_specialty, Microbiological culture, medicine.drug_class, raoultella planticola, Antibiotics, Disease, Education, Internal medicine, medicine, Dysuria, urine infections, biology, business.industry, resistance, biology.organism_classification, medicine.disease, Raoultella planticola, Ciprofloxacin, GV557-1198.995, Etiology, Medicine, medicine.symptom, business, Sports, Kidney disease, medicine.drug
Abstract

Kozioł Magdalena, Lewicki Marcin, Pawlicki Mateusz , Łopuszyńska Anna, Krasa Aleksandra, Piekarska Ewa, Krasowska Danuta. A rare case of Raoultella planticola urinary tract infection. A case report with literature review. Journal of Education, Health and Sport. 2020;10(8):470‑475. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.057 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.057 https://zenodo.org/record/4009554 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.08.2020. Revised: 15.08.2020. Accepted: 31.08.2020. A rare case of Raoultella planticola urinary tract infection. A case report with literature review Magdalena Kozioła, Marcin Lewickib, Mateusz Pawlickia , Anna Łopuszyńskaa, Aleksandra Krasaa, Ewa Piekarskaa, Danuta Krasowskac aStudent Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; bDepartment of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; cStudents’ Scientific Association at the Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 11, Lublin 20-081, Poland. Corresponding author: Magdalena Kozioł, magdalena.koziol@icloud.com ORCID ID: Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Marcin Lewicki https://orcid.org/0000-0003-1906-9326, lewicki-marcin@wp.pl Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Danuta Krasowska https://orcid.org/0000-0002-3015-1120, dana.krasowska@gmail.com Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract: Urine infections represent 40-50% of all infections in hospitalized patients. The most common uropathogens are E.coli, S.saprophitycus, and less commonly Enterobacteriaceae, such as Proteus mirabilis and Klebsiella pneumoniae. The spectrum of microorganisms isolated in hospital conditions may be wider. Raoultella planticola is a rare cause of human infections, so far only few cases of ZUM with this etiology have been described. A 56-years-old patient, with a history of cardiac disease, with exacerbation of chronic kidney disease, was admitted to the Department of Internal Medicine. The reason for admission was general deterioration. Many abnormalities in laboratory tests were detected. The doctors' attention was focused on the significant bacteriuria. Moreover, the patient reported dysuria symptoms. Material for urine microbiological culture was taken and empirical antibiotic therapy with ciprofloxacin started. The obtained result of urine culture allowed to identify the bacteria by R. planticola. As a result of the applied treatment, the patient's condition improved. An increasing number of infections with R. planticolla etiology is observed. The bacterium may lead to infections in many systems. The group of patients at risk of the disease includes people with renal dysfunction, who are immunosuppressed. Infections of R. planticolla etiology are usually characterized by good antibiotic response and positive prognosis. Key words: Raoultella planticola; urine infections; resistance

Published
2020

25. The analysis of a wide spectrum of activity of Sodium-Glucose co-transporter-2 inhibitors. A literature review

Author

Aleksandra Krasa, Anna Łopuszyńska, Mateusz Pawlicki, Marcin Lewicki, Danuta Krasowska, Ewa Piekarska, and Magdalena Kozioł

Subjects
obesity, medicine.medical_specialty, sodium-glucose co-transporter-2 (sglt2) inhibitors, Phlorizin, kidney, Education, chemistry.chemical_compound, Oral administration, Internal medicine, Diabetes mellitus, Nonalcoholic fatty liver disease, medicine, mechanisms, business.industry, Cholesterol, medicine.disease, Obesity, Endocrinology, chemistry, GV557-1198.995, Medicine, Uric acid, Animal studies, weight loss, business, Sports
Abstract

Kozioł Magdalena, Krasowska Danuta,LewickiMarcin,Pawlicki Mateusz, Łopuszyńska Anna, Krasa Aleksandra, Piekarska Ewa. The analysis of a wide spectrum of activity of Sodium-Glucose co-transporter-2 inhibitors. A literature review. Journal of Education, Health and Sport.2020;10(8):439449. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.054 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.054 https://zenodo.org/record/4008150 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2020. Revised: 05.08.2020. Accepted: 30.08.2020. The analysisof a wide spectrum of activity of sodium-glucose co-transporter-2 inhibitors. A literature review Magdalena Kozioła, Danuta Krasowskac, Marcin LewickibMateusz Pawlickia, AnnaŁopuszyńskaa, Aleksandra Krasaa, Ewa Piekarskaa aStudent Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; bDepartment of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; cStudents’ Scientific Association at the Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 11, Lublin 20-081, Poland. Corresponding author: Magdalena Kozioł, magdalena.koziol@icloud.com ORCID ID: Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Danuta Krasowska https://orcid.org/0000-0002-3015-1120, dana.krasowska@gmail.com Marcin Lewicki https://orcid.org/0000-0003-1906-9326, lewicki-marcin@wp.pl Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com ABSTRACT Introduction: The discovery of sodium-glucose co-transporter-2 inhibitors is attributed to phlorizin, which after oral administration caused the excretion of glucose in urine. Later studies showed that this effect was conditioned by SGLT-2 inhibition. However, this substance has not been used in the treatment of diabetes mellitus due to its non-selective action. Beeing also active against SGLT-1 transporters in alimentary tract, it causes osmotic diarrhea, dehydration and eventually malnutrition. Currently in Poland, gliflozins are used only in the treatment of diabetes mellitus, mainly type 2, especially with coexisting obesity and high cardio-vascular risk. However, as many human and animal studies show, the effect of SGLT2 inhibitors can be observed in many systems and organs. Results: The best known non-anti-diabetic action is the reduction of body fat and protection against fat accumulation following a high-calorie diet. These compounds reduce the production of endogenous fatty acids. Moreover, gliflozines lower the levels of cholesterol, triglycerides, uric acid and aminotransferases. They have a protective effect on the liver because they cause remission of nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD). They lower the cardiovascular risk and have an anti-inflammatory effect. Moreover, they inhibit vascular remodeling and improve hemodynamic conditions. Conclusions: According to many research, gliflozines have many collateral effects which can be used in the clinic as a treatment of diseases other than diabetes or coexisting with it. Obesity and cardiovascular diseases are among the most important health problems in the modern world. SGLT-2 inhibitors can prevent the above-mentioned diseases and reduce them. Key words: Sodium-glucose co-transporter-2 (SGLT2) inhibitors; obesity; weight loss; mechanisms; kidney.

Published
2020

26. Acne vulgaris and mental health

Author

Anna Łopuszyńska, Magdalena Kozioł, Ewa Piekarska, Halina Piecewicz-Szczęsna, Aleksandra Krasa, and Mateusz Pawlicki

Subjects
medicine.medical_specialty, business.industry, medicine.disease, Mental health, Quality of life (healthcare), Increased risk, medicine, Anxiety, Clinical severity, medicine.symptom, Psychiatry, business, Depression (differential diagnoses), Acne
Abstract

PawlickiMateusz, Łopuszyńska Anna, Kozioł Magdalena, Krasa Aleksandra,Piekarska Ewa, Piecewicz-Szczęsna Halina. Acne vulgaris and mental health.Journal of Education, Healthand Sport. 2021;11(9):208-214. eISSN 2391-8306. DOIhttp://dx.doi.org/10.12775/JEHS.2021.11.09.026 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.026 https://zenodo.org/record/5502488 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received:01.09.2021. Revised: 12.09.2021. Accepted: 15.09.2021. Acne vulgaris and mental health Mateusz Pawlicki1, Anna Łopuszyńska1, Magdalena Kozioł1, Aleksandra Krasa1, EwaPiekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska11, Lublin 20-080, Poland Corresponding author: Mateusz Pawlicki, pawlak32@gmail.com ORCID ID: Mateusz Pawlickihttps//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńskahttps://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Koziołhttps://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasahttps://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarskahttps://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Halina Piecewicz-Szczęsnahttps://orcid.org/0000-0002-0573-7226, halpiec@gmail.com Abstract Introduction: Acne vulgaris is one of the most common diseases in the world, which affects millions of people. Despite its objectively mild clinical severity, it is able to markedly change one’s appearance. Moreover it is said to be one of many factors that are responsible for mental health impairments. Results: Studies showed significant relation between acne and psychological disorders. Both depression and anxiety scores were higher in individuals with acne compared to healthy ones. Some studies reported an increased risk of suicide in this group as well. Research which included quality of life evaluation showed its impairment in larger part of respondents. Conclusions: Acne vulgaris is linked with an increased risk of serious psychiatric disorders. Therefore it is important to think about them when this condition is diagnosed. Key words: acne; mental health; depression; anxiety; suicide; quality of life

Published
2021

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