1. Anthraquinone analogues with inhibitory activities against influenza a virus from Polygonatum odoratum.
- Author
-
Pang, Xu, Zhao, Jian-Yuan, Liu, Ning, Chen, Ming-Hua, Zheng, Wei, Zhang, Jie, Chen, Xiao-Juan, Cen, Shan, Yu, Li-Yan, and Ma, Bai-Ping
- Subjects
- *
QUINONE , *INFLUENZA A virus , *HIGH performance liquid chromatography , *NUCLEAR magnetic resonance spectroscopy , *PLANTS , *PHYTOCHEMICALS , *RESEARCH funding , *MASS spectrometry , *DESCRIPTIVE statistics , *PLANT extracts , *MOLECULAR structure - Abstract
Three anthraquinone analogues (1–3) were isolated by phytochemical work on EtOAc-soluble ingredients extracted from the roots of Polygonatum odoratum. The structures of all isolates were elucidated by NMR, MS and CD experiments, of which 1 (polygodoquinone A) was identified as a new anthraquinone derivative. Specifically, 1 represents an unusual structure composed of a naphthoquinone derivative linked to an anthraquinone via a C-C bond. 1–3 exhibited remarkable influenza A virus inhibitory activity with IC50 values of 11.4, 11.0, and 2.3 μM, respectively, which were better than ribavirin as the positive control. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF