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368 results on '"Ariel, Federico"'

1. Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Author

Abrahamovych, Orest, Abu-farsakh, Niazy, Afanasieva, Halyna, Akpinar, Hale, Al Kharrat, Houssam, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Araki, Hiroshi, Argollo, Marjorie, Ariel, Federico, Armuzzi, Alessandro, Ashida, Toshifumi, Augustyn, Monika, Aumais, Guy, Azum, Martín, Baert, Filip, Balaz, Jozef, Balderramo, Domingo, Begun, Jakob, Berova, Temenuzhka, Billiauws, Lore, Blanco, Antonio, Bortlik, Martin, Bossa, Fabrizio, Bunkova, Elena, Cabello, Mercedes, Cao, Qian, Caprioli, Flavio, Cerqueira, Rute, Chachu, Karen, Chamouard, Patrick, Chen, Chunxiao, Chen, Yan, Chen, Baili, Chen, Dongfeng, Chen, Hong, Chen, Youxiang, Chen, Chou-chen, Cheon, Jaehee, Chen, Minhu, Chiu, Cheng-tang, Choi, Changhwan, Chow, Elizabeth, Cicala, Michele, Cintra, Aderson, Danilkiewicz, Wit, Datsenko, Olena, De Hertogh, Gert, De María, Julio, Del Valle Torrealba Medina, Leyanira, Deliang, Liu, Desreumaux, Pierre, Dewint, Pieter, Ding, Shigang, Doherty, Glen, Draganova, Raina, Dutré, Joris, Duvall, George, Egan, Laurence, Fahed, Julien, Fechner, Lars, Fedurco, Miroslav, Ferhat Celik, Aykut, Fernandez, Juan, Filip, Rafal, Fishman, Sigal, Flores, Cristina, Fogel, Ronald, Fowler, Sharyle, Francesconi, Carlos, Fujii, Toshimitsu, Fujiya, Mikihiro, Fukata, Masayuki, Fukuhara, Seiichiro, Furumoto, Yohei, G.Kiss, Gyula, Gachowski, Waldemar, Gao, Xiang, Gasbarrini, Antonio, Gawdis-wojnarska, Beata, Gaya, Daniel, Geccherle, Andrea, Gilletta De Saint Joseph, Cyrielle, Gimenez, Edgardo, Gionchetti, Paolo, Goldin, Eran, Golovchenko, Oleksandr, Gonciarz, Maciej, Gonen, Can, Gonzales, Chad, Gonzalez, Raquel, Gonzalez Segura, Gaston Julian, Gridnyev, Oleksiy, Gu, Fang, Gupta, Nitin, Gyokeres, Tibor, Haines, Melissa, Hebuterne, Xavier, Hedin, Charlotte, Hellstrom, Per, Hilmi, Ida Normiha, Hirai, Fumihito, Hisabe, Takashi, Hlavaty, Tibor, Hoentjen, Frank, Holtmann, Gerald, Horiki, Noriyuki, Horny, Ivo, Horvat, Gyula, Horvath, Frantisek, Hoshi, Namiko, Hosomi, Shuhei, Hospodarskyy, Ihor, Hou, Xiaohua, Hrdlicka, Ludek, Hu, Naizhong, Huang, Vivian, Huang, Caibin, Inaba, Tomoki, Ishiguro, Yoh, Ishihara, Shunji, Ishikawa, Takeshi, Iskandar, Heba, Israeli, Eran, Itaba, Soichi, Ivanishyn, Olha, Izbéki, Ferenc, Jain, Animesh, Jairath, Vipul, Jang, Byung Ik, Jiang, Chunmeng, Jones, Michael, Kagaya, Takashi, Kalimullina, Dilara, Karakina, Marina, Karatas, Ali, Kashimura, Hiroshi, Keret, Dan, Khovaeva, Yaroslava, Kierkus, Jaroslaw, Kim, Taeoh, Kim, Youngho, Kim, Hyo Jong, Klaus, Jochen, Kleczkowski, Dariusz, Klopocka, Maria, Kobayashi, Taku, Kobielusz-gembala, Iwona, Kojima, Yuichiro, Koo, Ja Seol, Kopon, Adam, Kopp, James, Koyama, Fumikazu, Koynarski, Vasil, Kravchenko, Tetiana, Kudo, Masatoshi, Kusunoki, Ryusaku, Kwon, Kwangan, Laclav, Martin, Lago, Paula, Laharie, David, Lasa, Juan, Lateef, Syed, Latinovic Radakovic, Tatjana, Lee, Kang Moon, Leszczyszyn, Jaroslaw, Li, Yan, Liu, Mei, Liu, Eashen, Lobaton Ortega, Triana, Lopatin, Denis, Lopes, Susana, Lovric Jovanovic, Mileva, Lubini, Marcio, Lukas, Milan, Maaser, Christian, Machytka, Evzen, Maemoto, Atsuo, Magro, Fernando, Marcet, Jorge, Marini, Eduardo, Marusawa, Hiroyuki, Matous, Jan, Matsumoto, Takayuki, Mendu, Shoba, Miao, Yinglei, Mihaly, Emese, Miheller, Pal, Ministro, Paula, Miyabayashi, Hideharu, Mohl, Wolfgang, Molnar, Martin, Moore, Gregory, Moran Faienzo, Gabriela, Morral, Eugeni Domenech, Motoya, Satoshi, Murali, Narayanachar, Mustaffa, Nazri Mohamad, Naem, Mohamed, Nakai, Katsuhiko, Nakajima, Koichi, Nakamoto, Yasunari, Nakamura, Masanao, Nancey, Stephane, Navaneethan, Udayakumar, Nawawi, Khairul Najmi Muhammad, Ninomiya, Tomoyuki, Novak, Janos, Oki, Motoji, Oliveira Santana, Genoile, Onizawa, Michio, Ono, Yohei, Osada, Taro, Osipenko, Marina, Owczarek, Danuta, Parente, Jose Miguel, Patel, Kamal, Patel, Bhaktasharan, Pedersen, Peder, Petroniene, Rima, Petrov, Asen, Petrova, Elina, Piquet, Marie-astrid, Pokrotnieks, Juris, Poroshina, Elena, Portela, Francisco, Pruthi, Jatinder S., Prystupa, Lyudmila, Pukitis, Aldis, Qiu, Yun, Rafalsky, Vladimir, Rainis, Tova, Ramos Junior, Odery, Rashid, Mohammed, Rayyan, Yasser, Reshetko, Olga, Ribeiro, Tarsila, Rivero, Montserrat, Roblin, Xavier, Romatowski, Jacek, Rowbotham, David, Ruffinengo, Orlando Enrique, Rydzewska-wyszkowska, Grazyna, Sablin, Oleg, Sai, Souken, Saibeni, Simone, Said, Rosaida Hj. Md., Sakuraba, Hirotake, Samaan, Mark, Sandborn, William, Saruta, Masayuki, Sauk, Jenny, Savarino, Edoardo Vincenzo, Schultz, Michael, Schulze, Joerg, Sedghi, Shahriar, Seidler, Ursula, Seksik, Philippe, Senturk, Omer, Shelton, Edward, Shimizu, Masahito, Shin, Sungjae, Shukla, Richa, Sigal, Michael, Silva Junior, Roberto, Simoes Neto, Joaquim, Siroky Jr., Milan, Smajstrla, Vit, Smid, Vaclav, Smiley, Sarah, Soledad Brunatto, Luciana, Stanislavchuk, Mykola, Stokesberry, David, Stone, Christian, Suiter, Daniel, Suzuki, Takayoshi, Svorcan, Petar, Takagi, Sho, Takagi, Tomohisa, Takamura, Masaaki, Takayama, Tetsuji, Takeuchi, Ken, Tanaka, Akihito, Tanaka, Hiroki, Tanash, Omar, Tang, Wen, Tankova, Ludmila, Teixeira Campos, Luciana, Thin, Lena, Tkachev, Alexander, Tolmanis, Ivars, Tsarynna, Nataliia, Tsonev, Nikolay, Tulassay, Zsolt, Ueo, Tetsuya, Unal, Nalan, Valuyskikh, Ekaterina, Van Dop, Willemijn, Vasilevskaya, Olga, Venugopal, Kannan, Verstockt, Bram, Viamonte, Manuel, Vyshyvanyuk, Vira, Wang, Bangmao, Wang, Xiaoyan, Wang, Jiangbin, Wang, Yufang, Wei, Shu-chen, Weisshof, Roni, Wisam, Sbeit, Wojcik, Katarzyna, Yakovlev, Alexey, Yasuda, Hiroshi, Ye, Byongduk, Yen, Hsu-heng, Yilmaz, Hasan, Yokoyama, Yoko, Yoon, Hyuk, Yoshida, Takeshi, Yurkiv, Andriy, Zaha, Osamu, Zaltman, Cyrla, Zhan, Qiang, Zhang, Hongjie, Zhang, Shutian, Zhu, Lanxiang, Zou, Duowu, Zou, Xiaoping, Zureikat, Firas, Rubin, David T, Allegretti, Jessica R, Panés, Julián, Shipitofsky, Nicole, Yarandi, Shadi S, Huang, Kuan-Hsiang Gary, Germinaro, Matthew, Wilson, Rebbecca, Zhang, Hongyan, Johanns, Jewel, Feagan, Brian G, Hisamatsu, Tadakazu, Lichtenstein, Gary R, Bressler, Brian, Peyrin-Biroulet, Laurent, Sands, Bruce E, and Dignass, Axel

Published
2025
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5. HSFA1a modulates plant heat stress responses and alters the 3D chromatin organization of enhancer-promoter interactions

Author

Huang, Ying, An, Jing, Sircar, Sanchari, Bergis, Clara, Lopes, Chloé Dias, He, Xiaoning, Da Costa, Barbara, Tan, Feng-Quan, Bazin, Jeremie, Antunez-Sanchez, Javier, Mammarella, Maria Florencia, Devani, Ravi-sureshbhai, Brik-Chaouche, Rim, Bendahmane, Abdelhafid, Frugier, Florian, Xia, Chongjing, Rothan, Christophe, Probst, Aline V., Mohamed, Zouine, Bergounioux, Catherine, Delarue, Marianne, Zhang, Yijing, Zheng, Shaojian, Crespi, Martin, Fragkostefanakis, Sotirios, Mahfouz, Magdy M., Ariel, Federico, Gutierrez-Marcos, Jose, Raynaud, Cécile, Latrasse, David, and Benhamed, Moussa

Published
2023
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8. Arabidopsis roots segmentation based on morphological operations and CRFs

Author

Orlando, José Ignacio, Manterola, Hugo Luis, Ferrante, Enzo, and Ariel, Federico

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Arabidopsis thaliana is a plant species widely utilized by scientists to estimate the impact of genetic differences in root morphological features. For this purpose, images of this plant after genetic modifications are taken to study differences in the root architecture. This task requires manual segmentations of radicular structures, although this is a particularly tedious and time-consuming labor. In this work, we present an unsupervised method for Arabidopsis thaliana root segmentation based on morphological operations and fully-connected Conditional Random Fields. Although other approaches have been proposed to this purpose, all of them are based on more complex and expensive imaging modalities. Our results prove that our method can be easily applied over images taken using conventional scanners, with a minor user intervention. A first data set, our results and a fully open source implementation are available online.

Published
2017

11. Apoplastic class III peroxidases PRX62 and PRX69 promote Arabidopsis root hair growth at low temperature

Author

Pacheco, Javier Martínez, Ranocha, Philippe, Kasulin, Luciana, Fusari, Corina M., Servi, Lucas, Aptekmann, Ariel. A., Gabarain, Victoria Berdion, Peralta, Juan Manuel, Borassi, Cecilia, Marzol, Eliana, Rodríguez-Garcia, Diana Rosa, del Carmen Rondón Guerrero, Yossmayer, Sardoy, Mariana Carignani, Ferrero, Lucía, Botto, Javier F., Meneses, Claudio, Ariel, Federico, Nadra, Alejandro D., Petrillo, Ezequiel, Dunand, Christophe, and Estevez, José M.

Published
2022
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15. Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial

Author

Ahn, Mi-Young, Akasbi, Miriam, Alatorre-Alexander, Jorge, Altclas, Javier David, Ariel, Federico, Ariza, Horacio Alberto, Atkar, Chandrasekhar, Bertetti, Anselmo, Bhattacharya, Meenakshi, Briones, Maria Luisa, Budhraja, Akshay, Burza, Aaliya, Camacho Ortiz, Adrian, Caricchio, Roberto, Casas, Marcelo, Cevoli Recio, Valeria, Choi, Won Suk, Cohen, Emilia, Comulada-Rivera, Angel, Cook, Paul, Cornejo Juarez, Dora Patricia, Daniel, Carnevali, Degrecci Relvas, Luiz Fernando, Dominguez Cherit, Jose Guillermo, Ellerin, Todd, Enikeev, Dmitry, Erico Tanni Minamoto, Suzana, Estrada, Vicente, Fiss, Elie, Furuichi, Motohiko, Giovanni Luz, Kleber, Goldman, Jason D., Gonzalez, Omar, Gordeev, Ivan, Gruenewald, Thomas, Hamamoto Sato, Victor Augusto, Heo, Eun Young, Heo, Jung Yeon, Hermida, Maria, Hirai, Yuji, Hutchinson, David, Iastrebner, Claudio, Ioachimescu, Octavian, Jain, Manish, Juliani Souza Lima, Maria Patelli, Khan, Akram, Kremer, Andreas E., Lawrie, Thomas, MacElwee, Mark, Madhani-Lovely, Farah, Malhotra, Vinay, Martínez Resendez, Michel Fernando, McKinnell, James, Milligan, Patrick, Minelli, Cesar, Moran Rodriguez, Miguel Angel, Parody, Maria Leonor, Paulin, Priscila, Pellegrini, Rita de Cassia, Pemu, Priscilla, Procopio Carvalho, Ana Carolina, Puoti, Massimo, Purow, Joshua, Ramesh, Mayur, Rea Neto, Alvaro, Robinson, Philip, Rodrigues, Cristhieni, Rojas Velasco, Gustavo, Saraiva, Jose Francisco Kerr, Scheinberg, Morton, Schreiber, Stefan, Scublinsky, Dario, Sevciovic Grumach, Anete, Shawa, Imad, Simon Campos, Jesus, Sofat, Nidhi, Som, Mousumi, Spinner, Christoph D., Sprinz, Eduardo, Stienecker, Roger, Suarez, Jose, Tachikawa, Natsuo, Tahir, Hasan, Tiffany, Brian, Vishnevsky, Alexander, Westheimer Cavalcante, Adilson, Zirpe, Kapil, Marconi, Vincent C, Ramanan, Athimalaipet V, de Bono, Stephanie, Kartman, Cynthia E, Krishnan, Venkatesh, Liao, Ran, Piruzeli, Maria Lucia B, Goldman, Jason D, de Cassia Pellegrini, Rita, Cardoso, Anabela, Chakladar, Sujatro, Crowe, Brenda, Reis, Paulo, Zhang, Xin, Adams, David H, and Ely, E Wesley

Published
2021
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17. Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Author

Rubin, David T, Allegretti, Jessica R, Panés, Julián, Shipitofsky, Nicole, Yarandi, Shadi S, Huang, Kuan-Hsiang Gary, Germinaro, Matthew, Wilson, Rebbecca, Zhang, Hongyan, Johanns, Jewel, Feagan, Brian G, Hisamatsu, Tadakazu, Lichtenstein, Gary R, Bressler, Brian, Peyrin-Biroulet, Laurent, Sands, Bruce E, Dignass, Axel, Abrahamovych, Orest, Abu-farsakh, Niazy, Afanasieva, Halyna, Akpinar, Hale, Al Kharrat, Houssam, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Araki, Hiroshi, Argollo, Marjorie, Ariel, Federico, Armuzzi, Alessandro, Ashida, Toshifumi, Augustyn, Monika, Aumais, Guy, Azum, Martín, Baert, Filip, Balaz, Jozef, Balderramo, Domingo, Begun, Jakob, Berova, Temenuzhka, Billiauws, Lore, Blanco, Antonio, Bortlik, Martin, Bossa, Fabrizio, Bunkova, Elena, Cabello, Mercedes, Cao, Qian, Caprioli, Flavio, Cerqueira, Rute, Chachu, Karen, Chamouard, Patrick, Chen, Chunxiao, Chen, Yan, Chen, Baili, Chen, Dongfeng, Chen, Hong, Chen, Youxiang, Chen, Chou-chen, Cheon, Jaehee, Chen, Minhu, Chiu, Cheng-tang, Choi, Changhwan, Chow, Elizabeth, Cicala, Michele, Cintra, Aderson, Danilkiewicz, Wit, Datsenko, Olena, De Hertogh, Gert, De María, Julio, Del Valle Torrealba Medina, Leyanira, Deliang, Liu, Desreumaux, Pierre, Dewint, Pieter, Ding, Shigang, Doherty, Glen, Draganova, Raina, Dutré, Joris, Duvall, George, Egan, Laurence, Fahed, Julien, Fechner, Lars, Fedurco, Miroslav, Ferhat Celik, Aykut, Fernandez, Juan, Filip, Rafal, Fishman, Sigal, Flores, Cristina, Fogel, Ronald, Fowler, Sharyle, Francesconi, Carlos, Fujii, Toshimitsu, Fujiya, Mikihiro, Fukata, Masayuki, Fukuhara, Seiichiro, Furumoto, Yohei, G.Kiss, Gyula, Gachowski, Waldemar, Gao, Xiang, Gasbarrini, Antonio, Gawdis-wojnarska, Beata, Gaya, Daniel, Geccherle, Andrea, Gilletta De Saint Joseph, Cyrielle, Gimenez, Edgardo, Gionchetti, Paolo, Goldin, Eran, Golovchenko, Oleksandr, Gonciarz, Maciej, Gonen, Can, Gonzales, Chad, Gonzalez, Raquel, Gonzalez Segura, Gaston Julian, Gridnyev, Oleksiy, Gu, Fang, Gupta, Nitin, Gyokeres, Tibor, Haines, Melissa, Hebuterne, Xavier, Hedin, Charlotte, Hellstrom, Per, Hilmi, Ida Normiha, Hirai, Fumihito, Hisabe, Takashi, Hlavaty, Tibor, Hoentjen, Frank, Holtmann, Gerald, Horiki, Noriyuki, Horny, Ivo, Horvat, Gyula, Horvath, Frantisek, Hoshi, Namiko, Hosomi, Shuhei, Hospodarskyy, Ihor, Hou, Xiaohua, Hrdlicka, Ludek, Hu, Naizhong, Huang, Vivian, Huang, Caibin, Inaba, Tomoki, Ishiguro, Yoh, Ishihara, Shunji, Ishikawa, Takeshi, Iskandar, Heba, Israeli, Eran, Itaba, Soichi, Ivanishyn, Olha, Izbéki, Ferenc, Jain, Animesh, Jairath, Vipul, Jang, Byung Ik, Jiang, Chunmeng, Jones, Michael, Kagaya, Takashi, Kalimullina, Dilara, Karakina, Marina, Karatas, Ali, Kashimura, Hiroshi, Keret, Dan, Khovaeva, Yaroslava, Kierkus, Jaroslaw, Kim, Taeoh, Kim, Youngho, Kim, Hyo Jong, Klaus, Jochen, Kleczkowski, Dariusz, Klopocka, Maria, Kobayashi, Taku, Kobielusz-gembala, Iwona, Kojima, Yuichiro, Koo, Ja Seol, Kopon, Adam, Kopp, James, Koyama, Fumikazu, Koynarski, Vasil, Kravchenko, Tetiana, Kudo, Masatoshi, Kusunoki, Ryusaku, Kwon, Kwangan, Laclav, Martin, Lago, Paula, Laharie, David, Lasa, Juan, Lateef, Syed, Latinovic Radakovic, Tatjana, Lee, Kang Moon, Leszczyszyn, Jaroslaw, Li, Yan, Liu, Mei, Liu, Eashen, Lobaton Ortega, Triana, Lopatin, Denis, Lopes, Susana, Lovric Jovanovic, Mileva, Lubini, Marcio, Lukas, Milan, Maaser, Christian, Machytka, Evzen, Maemoto, Atsuo, Magro, Fernando, Marcet, Jorge, Marini, Eduardo, Marusawa, Hiroyuki, Matous, Jan, Matsumoto, Takayuki, Mendu, Shoba, Miao, Yinglei, Mihaly, Emese, Miheller, Pal, Ministro, Paula, Miyabayashi, Hideharu, Mohl, Wolfgang, Molnar, Martin, Moore, Gregory, Moran Faienzo, Gabriela, Morral, Eugeni Domenech, Motoya, Satoshi, Murali, Narayanachar, Mustaffa, Nazri Mohamad, Naem, Mohamed, Nakai, Katsuhiko, Nakajima, Koichi, Nakamoto, Yasunari, Nakamura, Masanao, Nancey, Stephane, Navaneethan, Udayakumar, Nawawi, Khairul Najmi Muhammad, Ninomiya, Tomoyuki, Novak, Janos, Oki, Motoji, Oliveira Santana, Genoile, Onizawa, Michio, Ono, Yohei, Osada, Taro, Osipenko, Marina, Owczarek, Danuta, Parente, Jose Miguel, Patel, Kamal, Patel, Bhaktasharan, Pedersen, Peder, Petroniene, Rima, Petrov, Asen, Petrova, Elina, Piquet, Marie-astrid, Pokrotnieks, Juris, Poroshina, Elena, Portela, Francisco, Pruthi, Jatinder S., Prystupa, Lyudmila, Pukitis, Aldis, Qiu, Yun, Rafalsky, Vladimir, Rainis, Tova, Ramos Junior, Odery, Rashid, Mohammed, Rayyan, Yasser, Reshetko, Olga, Ribeiro, Tarsila, Rivero, Montserrat, Roblin, Xavier, Romatowski, Jacek, Rowbotham, David, Ruffinengo, Orlando Enrique, Rydzewska-wyszkowska, Grazyna, Sablin, Oleg, Sai, Souken, Saibeni, Simone, Said, Rosaida Hj. Md., Sakuraba, Hirotake, Samaan, Mark, Sandborn, William, Saruta, Masayuki, Sauk, Jenny, Savarino, Edoardo Vincenzo, Schultz, Michael, Schulze, Joerg, Sedghi, Shahriar, Seidler, Ursula, Seksik, Philippe, Senturk, Omer, Shelton, Edward, Shimizu, Masahito, Shin, Sungjae, Shukla, Richa, Sigal, Michael, Silva Junior, Roberto, Simoes Neto, Joaquim, Siroky Jr., Milan, Smajstrla, Vit, Smid, Vaclav, Smiley, Sarah, Soledad Brunatto, Luciana, Stanislavchuk, Mykola, Stokesberry, David, Stone, Christian, Suiter, Daniel, Suzuki, Takayoshi, Svorcan, Petar, Takagi, Sho, Takagi, Tomohisa, Takamura, Masaaki, Takayama, Tetsuji, Takeuchi, Ken, Tanaka, Akihito, Tanaka, Hiroki, Tanash, Omar, Tang, Wen, Tankova, Ludmila, Teixeira Campos, Luciana, Thin, Lena, Tkachev, Alexander, Tolmanis, Ivars, Tsarynna, Nataliia, Tsonev, Nikolay, Tulassay, Zsolt, Ueo, Tetsuya, Unal, Nalan, Valuyskikh, Ekaterina, Van Dop, Willemijn, Vasilevskaya, Olga, Venugopal, Kannan, Verstockt, Bram, Viamonte, Manuel, Vyshyvanyuk, Vira, Wang, Bangmao, Wang, Xiaoyan, Wang, Jiangbin, Wang, Yufang, Wei, Shu-chen, Weisshof, Roni, Wisam, Sbeit, Wojcik, Katarzyna, Yakovlev, Alexey, Yasuda, Hiroshi, Ye, Byongduk, Yen, Hsu-heng, Yilmaz, Hasan, Yokoyama, Yoko, Yoon, Hyuk, Yoshida, Takeshi, Yurkiv, Andriy, Zaha, Osamu, Zaltman, Cyrla, Zhan, Qiang, Zhang, Hongjie, Zhang, Shutian, Zhu, Lanxiang, Zou, Duowu, Zou, Xiaoping, and Zureikat, Firas

Abstract

Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.

Published
2025
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18. Genetic–epigenetic interplay in the determination of plant 3D genome organization.

Author

He, Xiaoning, Dias Lopes, Chloé, Pereyra-Bistrain, Leonardo I, Huang, Ying, An, Jing, Chaouche, Rim Brik, Zalzalé, Hugo, Wang, Qingyi, Ma, Xing, Antunez-Sanchez, Javier, Bergounioux, Catherine, Piquerez, Sophie, Fragkostefanakis, Sotirios, Zhang, Yijing, Zheng, Shaojian, Crespi, Martin, Mahfouz, Magdy M, Mathieu, Olivier, Ariel, Federico, and Gutierrez-Marcos, Jose

Published
2024
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21. A lateral organ boundaries domain transcription factor acts downstream of the auxin response factor 2 to control nodulation and root architecture in Medicago truncatula

Author

Kirolinko, Cristina, primary, Hobecker, Karen, additional, Cueva, Marianela, additional, Botto, Florencia, additional, Christ, Aurélie, additional, Niebel, Andreas, additional, Ariel, Federico, additional, Blanco, Flavio Antonio, additional, Crespi, Martín, additional, and Zanetti, María Eugenia, additional

Published
2024
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22. RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana

Author

Lehuedé, Tomás Urzúa, primary, Gabarain, Victoria Berdion, additional, Moyano, Tomas, additional, Ferrero, Lucia, additional, Ibeas, Miguel Angel, additional, Salinas-Grenet, Hernan, additional, Núñez-Lillo, Gerardo, additional, Acha, Romina, additional, Perez, Jorge, additional, Perotti, Florencia, additional, Miguel, Virginia Natali, additional, Spies, Fiorella Paola, additional, Rosas, Miguel A., additional, Shibata, Michitaro, additional, Rodríguez-García, Diana R., additional, Moreno, Adrian A., additional, Sugimoto, Keiko, additional, Sanguinet, Karen, additional, Meneses, Claudio, additional, Chan, Raquel L., additional, Ariel, Federico, additional, Alvarez, Jose M., additional, and Estevez, José M., additional

Published
2024
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25. Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

Author

Morin, Frederic, Rahman, Proton, Ariel, Federico, Berman, Alberto, Carrio, Judith, Lucero, Eleonora, Cocco, Jose Maldonado, Hidalgo, Rodolfo Pardo, Velasco, Jorge, Viola, Diego O., Grisar, Johannes, Resch, Heinrich, Scheinecker, Clemens, Melazzi, Ana Claudia, Roimicher, Luis, Scotton, Antonio Scafuto, Rodriguez, Aaron Alejandro Barrera, Molina, Francisco Fidencio Cons, Barragan, Sergio Duran, Skinner, Cassandra M., Tena, Cesar Francisco Pacheco, Remus, Cesar Ricardo Ramos, Rodriguez, Juan Cruz Rizo, Hong, Seung-Jae, Kang, Seong Wook, Lee, Chang Keun, Lee, Eun Bong, Lee, Sang Heon, Park, Min-Chan, Lee, Sang-Hoon, Dokoupilova, Eva, Dvorak, Zdenek, Malcova, Martina, Pvelka, Karel, Eklund, Kari K., Jarvinen, Pentti, Karjalainen, Anna, Paimela, Leena, Taniguchi, Yoshinori, Tsuda, Tokutaro, Tada, Kurisu, Dobashi, Hiroaki, Inui, Kentaro, Ueki, Yukitaka, Matsumoto, Yoshifuji, Hatta, Kazuhiro, Atsumi, Tatsuya, Goto, Hitoshi, Honjo, Shigeru, Matsui, Kiyoshi, Takakubo, Yuya, Neeck, Gunther, Wagner, Sylke, Braun, Jürgen, Blicharshi, Tomasz, Dudek, Anna, Hrycai, Pawel, Plebanski, Rafal, Drabiszcak-Piatkowska, Janina, Brzezicki, Jan, Krogulec, Marek, Opris-Belinski, Daniela, Ramazan, Ana Maria, Tronaru, Luminita, van de Sande, Marleen G., Matsievskaya, Galina, Schmidt, Evgeniya, Stanislav, Marina, Yakushin, Sergey, Ershova, Olga, Rebroy, Andrey, Churchill, Melvin A., Flint, Kathleen P., Greenwald, Maria, Howell, Mary P., Kaine, Jeffrey L., Kivitz, Alan, Klein, Steven J., Mueller, Eric C., Peters, Eric A., Querubin, Roel, Sayers, Michael E., Scoville, Craig D., Shanahan, Joseph C., Roseff, Richard, Hull, John E., Mallepalli, Jyothi R., Sebai, Mohamed B., Kimmel, Steven C., Goddard, David H., Mease, Philip J., Harris, Mark D., Mabaquiao, Arthur R., Diegel, Roger J., Thai, Christine, Rivera, Tania L., Perez-De Jesus, Amarilis, Soto-Raices, Oscar, Toro-Torres, Ramon, Pantojas, Carlos, Deodhar, Atul, van der Heijde, Désirée, Gensler, Lianne S, Kim, Tae-Hwan, Maksymowych, Walter P, Østergaard, Mikkel, Poddubnyy, Denis, Marzo-Ortega, Helena, Bessette, Louis, Tomita, Tetsuya, Leung, Ann, Hojnik, Maja, Gallo, Gaia, Li, Xiaoqi, Adams, David, Carlier, Hilde, and Sieper, Joachim

Published
2020
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27. Long noncoding RNA‐mediated epigenetic regulation of auxin‐related genes controls shade avoidance syndrome in Arabidopsis

Author

Mammarella, María Florencia, primary, Lucero, Leandro, additional, Hussain, Nosheen, additional, Muñoz‐Lopez, Aitor, additional, Huang, Ying, additional, Ferrero, Lucia, additional, Fernandez‐Milmanda, Guadalupe L, additional, Manavella, Pablo, additional, Benhamed, Moussa, additional, Crespi, Martin, additional, Ballare, Carlos L, additional, Gutiérrez Marcos, José, additional, Cubas, Pilar, additional, and Ariel, Federico, additional

Published
2023
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32. Transcription factor NAC1 activates expression of peptidase-encoding AtCEPs in roots to limit root hair growth

Author

Rodríguez-García, Diana R, primary, Rondón Guerrero, Yossmayer del Carmen, additional, Ferrero, Lucía, additional, Rossi, Andrés Hugo, additional, Miglietta, Esteban A, additional, Aptekmann, Ariel A, additional, Marzol, Eliana, additional, Martínez Pacheco, Javier, additional, Carignani, Mariana, additional, Berdion Gabarain, Victoria, additional, Lopez, Leonel E, additional, Díaz Dominguez, Gabriela, additional, Borassi, Cecilia, additional, Sánchez-Serrano, José Juan, additional, Xu, Lin, additional, Nadra, Alejandro D, additional, Rojo, Enrique, additional, Ariel, Federico, additional, and Estevez, José M, additional

Published
2023
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34. Identification of a stable epi-allele associated with flower development and low bunch compactness in a somatic variant of Tempranillo Tinto

Author

Alañón-Sánchez, Noelia, Ferradas, Yolanda, Lijavetzky, Diego, Ferrero, Lucía, Martínez-Zapater, José M., Ariel, Federico, Carbonell-Bejerano, Pablo, Ibáñez Marcos, Javier, Alañón-Sánchez, Noelia, Ferradas, Yolanda, Lijavetzky, Diego, Ferrero, Lucía, Martínez-Zapater, José M., Ariel, Federico, Carbonell-Bejerano, Pablo, and Ibáñez Marcos, Javier

Abstract

Grapevine cultivars are vegetatively propagated to preserve their varietal characteristics. However, spontaneous somatic variations that occur and are maintained during cycles of vegetative growth offer opportunities for the natural improvement of traditional grape cultivars. One advantageous trait for winegrowing is reduced bunch compactness, which decreases the susceptibility to pests and fungal diseases and favor an even berry ripening. In this study, we examined a loose bunch somatic variant of Tempranillo Tinto cultivar (TT) to elucidate the molecular basis underlying this variation. The variant displayed a masculinized flower phenotype, characterized by an underdeveloped yet functional gynoecium, with reduced development of the style, stigma and septum, as compared to the complete hermaphroditic flowers typically observed in TT. Genetic analysis of its self-progeny demonstrated the co-segregation of the masculinized flower phenotype with the hermaphrodite allele of the grape sex locus (SDR)[1]. While genome re-sequencing did not identify any genetic variation within the SDR locus, an RNA-seq analysis identified one SDR-located gene over-expressed in the somatic variant compared to a control TT clone. The hermaphrodite allele was specifically over-expressed in the variant. Both Illumina WGBS and Nanopore epigenomic analyses identified a hermaphrodite allele-specific hyper-methylated region upstream of the upregulated gene. Analysis of chromatin conformation capture (3C) revealed a three-dimensional rearrangement of the locus, including the presence of a novel 36 kb chromatin loop delimiting the hyper-methylated region, which could be responsible for the over-expression and the phenotype. These findings indicate that somatic epi-alleles in the SDR locus can determine variation in gynoecium development leading to decreased fruit set and looser bunches in grapevine.

Published
2023

35. Transcription factor NAC1 activates expression of peptidase-encoding AtCEPs in roots to limit root hair growth

Author

#NODATA#, Rodríguez-García, Diana R, Rondón Guerrero, Yossmayer Del Carmen, Ferrero, Lucía, Rossi, Andrés Hugo, Miglietta, Esteban A, Aptekmann, Ariel A, Marzol, Eliana, Martínez Pacheco, Javier, Carignani, Mariana, Berdion Gabarain, Victoria, Lopez, Leonel E, Díaz Dominguez, Gabriela, Borassi, Cecilia, Sánchez-Serrano, José Juan, Xu, Lin, Nadra, Alejandro D, Rojo, Enrique, Ariel, Federico, Estevez, José M, #NODATA#, Rodríguez-García, Diana R, Rondón Guerrero, Yossmayer Del Carmen, Ferrero, Lucía, Rossi, Andrés Hugo, Miglietta, Esteban A, Aptekmann, Ariel A, Marzol, Eliana, Martínez Pacheco, Javier, Carignani, Mariana, Berdion Gabarain, Victoria, Lopez, Leonel E, Díaz Dominguez, Gabriela, Borassi, Cecilia, Sánchez-Serrano, José Juan, Xu, Lin, Nadra, Alejandro D, Rojo, Enrique, Ariel, Federico, and Estevez, José M

Abstract

Plant genomes encode a unique group of papain-type Cysteine EndoPeptidases (CysEPs) containing a KDEL endoplasmic reticulum (ER) retention signal (KDEL-CysEPs or CEPs). CEPs process the cell-wall scaffolding EXTENSIN (EXT) proteins that regulate de novo cell-wall formation and cell expansion. Since CEPs cleave EXTs and EXT-related proteins, acting as cell-wall-weakening agents, they may play a role in cell elongation. The Arabidopsis (Arabidopsis thaliana) genome encodes 3 CEPs (AtCPE1-AtCEP3). Here, we report that the genes encoding these 3 Arabidopsis CEPs are highly expressed in root-hair (RH) cell files. Single mutants have no evident abnormal RH phenotype, but atcep1-3 atcep3-2 and atcep1-3 atcep2-2 double mutants have longer RHs than wild-type (Wt) plants, suggesting that expression of AtCEPs in root trichoblasts restrains polar elongation of the RH. We provide evidence that the transcription factor NAC1 (petunia NAM and Arabidopsis ATAF1, ATAF2, and CUC2) activates AtCEPs expression in roots to limit RH growth. Chromatin immunoprecipitation indicates that NAC1 binds to the promoter of AtCEP1, AtCEP2, and, to a lower extent, AtCEP3 and may directly regulate their expression. Inducible NAC1 overexpression increases AtCEP1 and AtCEP2 transcript levels in roots and leads to reduced RH growth while the loss of function nac1-2 mutation reduces AtCEP1-AtCEP3 gene expression and enhances RH growth. Likewise, expression of a dominant chimeric NAC1-SRDX repressor construct leads to increased RH length. Finally, we show that RH cell walls in the atcep1-3 atcep3-2 double mutant have reduced levels of EXT deposition, suggesting that the defects in RH elongation are linked to alterations in EXT processing and accumulation. Our results support the involvement of AtCEPs in controlling RH polar growth through EXT processing and insolubilization at the cell wall.

Published
2023

36. The plant noncoding transcriptome: a versatile environmental sensor

Author

Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación la Caixa, International Centre for Genetic Engineering and Biotechnology, Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina), Chorostecki, Uciel, Bologna, Nicolas Gerardo, Ariel, Federico, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación la Caixa, International Centre for Genetic Engineering and Biotechnology, Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina), Chorostecki, Uciel, Bologna, Nicolas Gerardo, and Ariel, Federico

Abstract

Plant noncoding RNA transcripts have gained increasing attention in recent years due to growing evidence that they can regulate developmental plasticity. In this review article, we comprehensively analyze the relationship between noncoding RNA transcripts in plants and their response to environmental cues. We first provide an overview of the various noncoding transcript types, including long and small RNAs, and how the environment modulates their performance. We then highlight the importance of noncoding RNA secondary structure for their molecular and biological functions. Finally, we discuss recent studies that have unveiled the functional significance of specific long noncoding transcripts and their molecular partners within ribonucleoprotein complexes during development and in response to biotic and abiotic stress. Overall, this review sheds light on the fascinating and complex relationship between dynamic noncoding transcription and plant environmental responses, and highlights the need for further research to uncover the underlying molecular mechanisms and exploit the potential of noncoding transcripts for crop resilience in the context of global warming.

Published
2023

37. The C subunit of the nuclear factor Y binds to the Cyclin P4;1 promoter to modulate nodule organogenesis and infection during symbiosis in Phaseolus vulgaris.

Author

Roda, Carla, Clúa, Joaquín, Eylenstein, Andrés, Greco, Micaela, Ariel, Federico, Zanetti, María Eugenia, and Blanco, Flavio Antonio

Subjects
CYCLINS, NITROGEN fixation, SYMBIOSIS, MORPHOGENESIS, COMMON bean, SOIL microbiology
Abstract

This article explores the role of the C subunit of the nuclear factor Y (NF-Y) in the symbiotic relationship between Phaseolus vulgaris (common bean) plants and soil microorganisms. The interaction between the plants and rhizobia leads to the formation of nodules, where nitrogen fixation occurs. The study found that the NF-Y subunit PvNF-YC1 directly binds to a gene involved in the cell cycle and nodule formation. Additionally, the study identified the PvCYCP4;1 cyclin gene as being crucial for root growth, nodule formation, and rhizobial infection in common bean. The findings shed light on the regulatory mechanisms of the cell cycle during symbiotic interactions in common bean plants. [Extracted from the article]

Published
2024
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38. Transcription factor NAC1 activates expression of peptidase-encoding AtCEPs in roots to limit root hair growth.

Author

Rodríguez-García, Diana R, Rondón Guerrero, Yossmayer del Carmen, Ferrero, Lucía, Rossi, Andrés Hugo, Miglietta, Esteban A, Aptekmann, Ariel A, Marzol, Eliana, Martínez Pacheco, Javier, Carignani, Mariana, Berdion Gabarain, Victoria, Lopez, Leonel E, Díaz Dominguez, Gabriela, Borassi, Cecilia, Sánchez-Serrano, José Juan, Xu, Lin, Nadra, Alejandro D, Rojo, Enrique, Ariel, Federico, and Estevez, José M

Published
2024
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40. NAC1 directs CEP1-CEP3 peptidase expression and decreases cell wall extensins linked to root hair growth in Arabidopsis

Author

Rodriguez-Garcia, Diana Rosa, primary, Marzol, Eliana, additional, Rondon Guerrero, Yossmayer del Carmen, additional, Ferrero, Lucía V., additional, Rossi, Andrés H., additional, Miglietta, Esteban A, additional, Aptekmann, Ariel Alejandro, additional, Martinez Pacheco, Javier, additional, Carignani, Mariana, additional, Berdión Gabarain, Victoria, additional, Lopez, Leonel E, additional, Diaz Dominguez, Gabriela, additional, Sanchez-Serrano, Jose J., additional, Xu, Lin, additional, Nadra, Alejandro D, additional, Ariel, Federico D., additional, Rojo, Enrique, additional, and Estevez, Jose, additional

Published
2023
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41. Long noncoding RNA-mediated epigenetic regulation of auxin-related genes controlling shade avoidance syndrome in Arabidopsis thaliana

Author

Mammarella, Maria Florencia, primary, Lucero, Leandro, additional, Hussain, Nosheen, additional, Muñoz-Lopez, Aitor, additional, Huang, Ying, additional, Ferrero, Lucia, additional, Fernandez-Milmanda, Guadalupe, additional, Manavella, Pablo A, additional, Benhamed, Moussa, additional, Crespi, Martin, additional, Ballare, Carlos, additional, Gutierrez-Marcos, José, additional, Cubas, Pilar, additional, and Ariel, Federico, additional

Published
2023
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