1. Gut microbiota analysis in pediatric‐onset multiple sclerosis compared to pediatric monophasic demyelinating syndromes and pediatric controls
- Author
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Arlette L. Bruijstens, Sandy Molenaar, Yu Yi M. Wong, Robert Kraaij, Rinze F. Neuteboom, Neurology, and Internal Medicine
- Subjects
Neurology ,Neurology (clinical) - Abstract
Background and purpose: Gut microbiota dysbiosis may lead to proinflammatory conditions contributing to multiple sclerosis (MS) etiology. Pediatric-onset MS patients are close to biological disease onset and less exposed to confounders. Therefore, this study investigated gut microbiota composition and functional pathways in pediatric-onset MS, compared to monophasic acquired demyelinating syndromes (mADS) and healthy controls (HCs). Methods: Pediatric participants were selected from the Dutch national prospective cohort study including ADS patients and HCs 2 = 3.7%, p = 0.013), and higher abundance of numerous individual resident microbes and functional microbial pathways. Conclusions: Previous results of gut microbiota composition and predicted functional features could not be validated in this Dutch pediatric-onset MS cohort using a more sensitive 16S pipeline, although it was limited by sample size and DMT use. Notably, several other host-related factors were found to associate with gut microbiota variation, especially BMI.
- Published
- 2022