91 results on '"Asife Sahinarslan"'
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2. Determinação do Tecido Cicatricial do Miocárdio no Fenômeno de Fluxo Coronário Lento e a Relação entre a Quantidade de Tecido Cicatricial e o Nt-ProBNP
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Mustafa Candemir, Asife Şahinarslan, Merve Yazol, Yusuf Ali Öner, and Bülent Boyacı
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Insuficiência Cardiaca ,Reserva Fracionada de Fluxo Miocárdico ,Cicatriz Hipertrófica ,Prognóstico ,Peptídeo Natriurético Tipo C ,Fibrose Endomiocárdica ,Espectroscopia de Ressonância Magnética/métodos ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Resumo Fundamento A fisiopatologia e o prognóstico não estão claramente determinados nos pacientes com fenômeno do fluxo coronário lento (FCL). Esses pacientes apresentam várias condições clínicas, que variam desde quadro assintomático até internação hospitalar com morte cardíaca súbita. Objetivos Nosso objetivo foi avaliar os achados da ressonância magnética cardíaca (RMC) com o realce tardio pelo gadolínio (RTG), como um indicador de fibrose miocárdica. Também buscamos determinar a relação entre a presença de fibrose miocárdica e os níveis de NT-proBNP em pacientes com FCL na artéria coronária descendente anterior esquerda (DAE). Métodos Ao todo, 35 pacientes, entre 31 e 75 anos de idade, foram incluídos. Os pacientes estudados (n=19) apresentaram artérias coronárias epicárdicas normais na angiografia, mas tinham FCL na DAE. O grupo controle de pacientes (n=16) apresentou artérias coronárias epicárdicas normais e níveis de escore TIMI normais na angiografia. Em ambos os grupos, os pacientes foram examinados com RMC para a detecção de presença de fibrose miocárdica. Além disso, níveis plasmáticos de NT-proBNP foram medidos. Valores de p < 0,05 foram considerados significativos. Resultados A taxa de fibrose miocárdica foi significativamente maior na RMC para os pacientes com FCL (p=0.018). Uma quantidade variável de tecido cicatricial foi detectada no ápice ventricular esquerdo em 7 pacientes e nas regiões inferior e inferolateral em 3 pacientes. Não foram observadas diferenças nos níveis de NT-proBNP nos pacientes com FCL. Entretanto, os níveis de NT-proBNP foram maiores nos pacientes com FCL, que apresentaram fibrose miocárdica na RMC (p=0.022). Conclusões Em suma, o RTG na RMC mostrou que a cicatriz miocárdica isquêmica pode estar presente nos pacientes com FCL. Esses resultados indicam que o FCL pode nem sempre ser inofensivo. (Arq Bras Cardiol. 2020; 114(3):540-551)
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3. Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis
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Mehmet Kadri Akboga, Adnan Abacı, Uğur Canpolat, Cağrı Yayla, Asife Sahinarslan, Kadri Açıkgöz, Serkan Çay, Serkan Topaloğlu, Dursun Aras, and Sinan Aydoğdu
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inflammation ,red cell distribution width ,mitral valve stenosis ,rheumatic mitral stenosis. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: As an indicator of variability in circulating erythrocyte size, red cell distribution width (RDW) is linked to chronic inflammation. The association of rheumatic heart valve stenosis and inflammation is also well-known. This study aimed to assess the relationship between RDW and presence and severity of rheumatic mitral valve stenosis (RMVS). Methods: A total of 417 consecutive patients with RMVS, and 81 age- and -gender matched healthy control subjects were included in the study between February 2009 and April 2014. Transthoracic echocardiography and demographic characteristics were recorded for all participants. Results: Baseline characteristics were similar in the two groups. However, median RDW was significantly higher in patients with RMVS compared to control group (14.4% [11.3- 19.6] vs. 13.6% [11.6-18.1], p
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- 2015
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4. Left atrial contractile longitudinal strain determines intrinsic left atrial function regardless of load status and left ventricular deformation
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Burak Sezenöz, Asife Sahinarslan, Betül Ayça Yamak, Selim Turgay Arınsoy, and Serkan Ünlü
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medicine.medical_specialty ,Longitudinal strain ,Heart Ventricles ,medicine.medical_treatment ,Hemodynamics ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Left atrial ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Dialysis ,Cardiac imaging ,business.industry ,Volume (thermodynamics) ,Echocardiography ,Cardiology ,Atrial Function, Left ,Hemodialysis ,Deformation (engineering) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Purpose Left atrial (LA) longitudinal strain (S) has been proposed as a superior, non-invasive parameter over LA volumetric assessment. LAS has diagnostic and prognostic value in many cardiovascular pathologies. Nevertheless, the acute effect of hemodynamic changes on LAS indices is not well-established. We sought to identify volume independent physiomechanical changes in LA and interrelation between LA and left ventricular (LV) strain indices following a large amount of fluid loss provided by hemodialysis. Methods Seventy-five patients between 18 and 85 years of age under hemodialysis therapy were included. The echocardiographic images were obtained before and after hemodialysis. Phasic LAS and LV global longitudinal strain (GLS) were calculated. The impact of volume depletion on echocardiographic measurements and their temporal correlation were calculated. Results LV and LA dimensions,volumes and LV, LA reservoir, and conduit deformation showed a significant decrease after hemodialysis. No significant change was observed for LAS(contraction) (p = 0.203). The ultrafiltrated volume was significantly correlated with the changes in LVGLS (r = 0.75, p < 0.001), and LAS(reservoir) (r = 0.81, p < 0.001) and LA total emptying volume (r = 0.80, p < 0.001). Absolute changes in LAS(reservoir) and LVGLS were strongly correlated (r = 0.83, p < 0.001). There was no correlation between absolute changes in LAS(contraction) and LVGLS or ultrafiltrated volume (p = NS, both). Conclusion LA reservoir and conduit LS are highly volume dependent strain parameters and are strongly correlated with LV deformation along with ultrafiltrated volume. Acute excessive volume depletion or LV deformation have no influence on LAS(contraction). It is important to identify independent easily accessible functional parameters for the LA which would improve clinical evaluation.
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- 2021
5. Analysis of ambulatory blood pressure monitoring data in patients with ankylosing spondylitis without clinically evident cardiovascular disease
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Burcu Candemir, Mustafa Candemir, Emrullah Kiziltunc, Asife Sahinarslan, Burcu Cihan, and Serdar Nurkoç
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medicine.medical_specialty ,Ambulatory blood pressure ,Diastole ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Spondylitis, Ankylosing ,030212 general & internal medicine ,Ankylosing spondylitis ,biology ,business.industry ,Dipper ,Blood Pressure Monitoring, Ambulatory ,biology.organism_classification ,medicine.disease ,Pulse pressure ,Cardiovascular Diseases ,Hypertension ,Ambulatory ,Cardiology ,Arterial stiffness ,business - Abstract
Ankylosing spondylitis (AS) is associated with an increased risk of cardiovascular morbidity and mortality. Parameters, such as non-dipper, average real variability (ARV), pulse pressure index (PPI), and ambulatory arterial stiffness index (AASI) obtained from ambulatory blood pressure monitoring (ABPM), provide information about adverse cardiovascular outcomes. In this study, these indexes were evaluated in patients with AS. Sixty-five patients with AS and 65 control subjects were included in this study. Non-dipper pattern, ARV, PPI, and AASI parameters were assessed using 24-h ABPM recordings. Twenty-four-hour systolic, diastolic, mean standard deviation, PPI, ARV, and AASI were higher in patients with AS (p
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- 2022
6. Relationship Between Systemic Immune-Inflammation Index (SII) and the Severity of Stable Coronary Artery Disease
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Mustafa Candemir, Asife Sahinarslan, Serdar Nurkoç, and Emrullah Kiziltunc
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Blood Platelets ,Male ,medicine.medical_specialty ,Multivariate statistics ,Neutrophils ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Logistic regression ,Risk Assessment ,Severity of Illness Index ,Coronary artery disease ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,White blood cell ,medicine ,Humans ,Angina, Stable ,Lymphocyte Count ,Lymphocytes ,Coronary atherosclerosis ,Aged ,Retrospective Studies ,030304 developmental biology ,Inflammation ,0303 health sciences ,Platelet Count ,business.industry ,Retrospective cohort study ,Odds ratio ,Middle Aged ,Prognosis ,medicine.disease ,Cross-Sectional Studies ,medicine.anatomical_structure ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Systemic immune-inflammation index (SII; platelet count × neutrophil-to-lymphocyte ratio), a novel marker, predicts adverse clinical outcomes in coronary artery diseases (CAD). We hypothesized that SII could provide more valuable information in assessing the severity of CAD than ratios obtained from other white blood cell subtypes. Patients (n = 669) who underwent coronary angiography were analyzed in this retrospective study. We analyzed the relation between the SII and the angiographic severity of CAD. The severity of coronary atherosclerosis was determined by the SYNTAX score (SxS). Patients with CAD were divided into 3 groups according to the SxS. Multivariate logistic analysis was used to assess risk factors of CAD. In multivariate logistic regression analysis, the SII (odds ratio: 1.004; 95% CI: 1.001-1.007; P = .015) was an independent predictor of high SxS. Additionally, there was a positive correlation between SII and SxS (Rho: 0.630, P ≤ .001). In the receiver-operating characteristic curve analysis, SII with an optimal cutoff value of 750 × 103 predicted the severe coronary lesion with a sensitivity of 86.2% and specificity of 87.3%. The SII, an inexpensive and easily measurable laboratory variable, was significantly associated with the severity of CAD and high SxS in patients with stable angina pectoris.
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- 2021
7. Prevalence and associated risk factors of coronary artery disease in patients with a zero coronary calcium score
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Gonca Erbaş, Fatih Oncu, Mahi Nur Cerit, Mehmet Araç, Zeynep Sezgi Erdal, Koray Kilic, Asife Sahinarslan, Aydan Avdan Aslan, Halit Nahit Şendur, and Emetullah Cindil
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Male ,medicine.medical_specialty ,Multivariate analysis ,Cardiovascular risk factors ,Coronary Artery Disease ,Coronary Angiography ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Male gender ,Aged ,business.industry ,Coronary computed tomography angiography ,Middle Aged ,medicine.disease ,Predictive value ,Coronary Calcium Score ,030220 oncology & carcinogenesis ,Cardiology ,Calcium ,Female ,business - Abstract
Purpose: A zero coronary calcium score (CCS) is not able to provide a definite exclusion for coronary arterydisease (CAD). The goal of this study was to determine the prevalence and associated cardiovascular risk factorsof CAD in patients with zero CCS.Methods: Six hundred thirteen patients with zero CCS referred to coronary calcium score analysis (CCSA) andcoronary computed tomography angiography (CCTA) with suspicion of CAD were included. The descriptive,univariate, and multivariate analyses were used to determine the prevalence and predictors of CAD presence.Results: Among 613 patients, 17 patients (2.7%) have NCCP, and obstructive CAD was found in 3 patients(0.48%). Multivariate analysis revealed that male gender and older age (≥50 years) were significantly associatedwith the presence of noncalcified coronary plaques (NCCP) (p < 0.05). The receiver operating characteristic(ROC) curve analysis showed that the male gender and older age (≥50 years) model had 70.6% sensitivity and84.2% specificity for predicting NCCP.Conclusion: A non-negligible portion of patients with zero CCS had CAD. Male gender and older age (≥50 years)were independently associated with NCCP. Due to the high specificity value (84.2%) and negative predictivevalue (99.0%) of the male gender and older age (≥50 years) model, selective use of CCTA is recommended in<50 years old female patients to avoid unnecessary radiation exposure
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- 2021
8. Long-term vitamin-K antagonist use and coronary artery calcification
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Burak Sezenöz, Mehmet Araç, Asife Sahinarslan, Ridvan Yalcin, Gökhan Gökalp, Hüseyin Koray Kiliç, Gonca Erbaş, and Serkan Ünlü
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medicine.medical_specialty ,medicine.drug_class ,Computed tomography ,Coronary calcium ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Vascular Calcification ,medicine.diagnostic_test ,business.industry ,Vitamins ,Vitamin K antagonist ,Coronary Vessels ,Coronary arteries ,Regimen ,medicine.anatomical_structure ,Coronary artery calcification ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Agatston score ,Tomography, X-Ray Computed ,Artery - Abstract
Background The aim of this study was to investigate the impact of vitamin K antagonist (VKA) therapy on coronary artery calcification (CAC) by comparing long-term VKA users with metallic prosthetic valves (MPVs) and VKA-free patients undergoing coronary calcium scoring for cardiovascular (CV) risk stratification. Methods A total of 108 patients (43 VKA users with MPV and 65 gender-, age-, and risk-factor-matched VKA-free patients) were included in the study. CAC was determined via computed tomography (CT) and quantified on the basis of the Agatston score. The VKA group comprised patients who had an MPV for longer than 5 years, which entailed long-term VKA use. Results Long-term VKA users had more calcified coronary arteries compared with the control group (178.1 +/- 278 vs. 61.1 +/- 130.6,p= 0.01). There was no difference between groups in terms of traditional CV risk factors. The mean duration of VKA use was 15 +/- 7 years for the patients with MPV. There was no correlation between the duration of VKA use and mean Agatston score (r= 0.2,p= 0.215). Conclusion With its unique selection of patient groups, our study extends the findings of previous research that long-term VKA use is related to CAC as detected via CT scanning. The longer and more potent VKA regimen required for MPV patients is the primary cause of CAC in this group.
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- 2020
9. High-sensitive troponin T increase after hemodialysis is associated with left ventricular global longitudinal strain and ultrafiltration rate
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Serkan Ünlü, Ozlem Gulbahar, Nuri Bülent Boyacı, Selim Turgay Arınsoy, Gökhan Gökalp, Asife Sahinarslan, Burak Sezenöz, Özden Seçkin, and Orhan Uludag
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Adult ,medicine.medical_specialty ,Acute coronary syndrome ,Longitudinal strain ,Heart Ventricles ,medicine.medical_treatment ,Ultrafiltration ,macromolecular substances ,Clinical Cardiology ,030204 cardiovascular system & hematology ,High sensitive ,Contractility ,03 medical and health sciences ,0302 clinical medicine ,Troponin T ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Dialysis ,biology ,business.industry ,General Medicine ,medicine.disease ,musculoskeletal system ,Troponin ,Ultrafiltration (renal) ,biology.protein ,Cardiology ,Kidney Failure, Chronic ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Circulating troponin levels are both stable and higher in patients with end-stage renal disease, even in the absence of acute coronary syndrome. These patients commonly have underlying cardiac problems that frequently cause troponin elevation. The effect of hemodialysis (HD) on troponin levels has not been well elucidated. Thus, investigated herein is the relationship between the changes in troponin levels along with left ventricular deformation and volume depletion in patients with end-stage renal disease. Methods: Patients included were between 18 and 85 years of age and were receiving hemodialysis for at least 6 months. High sensitive cardiac troponin T (hs-cTnT) levels were studied in blood samples taken at the beginning and end of HD. Two-dimensional speckle tracking strain imaging was used to evaluate myocardial contractility. Results: Seventy patients (50.7 ± 16.9 years of age, 27 women) were included in study. The mean volume of ultrafiltration was 3260 ± 990 mL. A significant increase in circulating hs-cTnT levels was observed, as well as a prominent decrease in left ventricular global longitudinal strain (GLS) after HD (52.4 ± 40.2 ng/L vs. 66.8 ± 48.5 ng/L, p < 0.001 and 20.1 ± 3.6% vs. 16.8 ± 3.8% p < 0.001, respectively). Moreover, ultrafiltration rate and GLS were found as the strongest independent variables in relation to the relative increase in hs-cTnT. Conclusions: Hemodialysis can cause a significant increase in hsTnT. This can jeopardize the accuracy of clinical diagnoses based on hs-TnT measurements. GLS may be used as a determinant of this hs-TnT increase. The influence of HD on the cardiovascular system should be kept in mind to prevent unnecessary interventions.
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- 2020
10. Turkish Society of Cardiology Consensus Paper on Evaluation and Treatment of Resistant Hypertension
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Aylin Yildirir, Ozgul Ucar Elalmis, Emine Gazi, Erdal Belen, Gülay Ulusal Okyay, Asife Sahinarslan, Ulver Derici, Reviewers Atila Bitigen, Meryem Aktoz, Neslihan Bascil Tutuncu, and Cigdem Ozkan
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medicine.medical_specialty ,business.industry ,Turkish ,Family medicine ,medicine ,language ,Resistant hypertension ,MEDLINE ,Cardiology and Cardiovascular Medicine ,business ,language.human_language - Published
- 2020
11. P342 Left atrial contraction longitudinal strain is a volume-independet parameter
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Burak Sezenöz, Atiye Çengel, Serkan Ünlü, Asife Sahinarslan, and Turgay Arinsoy
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medicine.medical_specialty ,Contraction (grammar) ,Longitudinal strain ,business.industry ,Conduit implant ,Left atrium ,Atrial fibrillation ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Left atrial ,Hypovolemia ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The left atrium (LA) is the main contributor of left ventricular (LV) filling. LA volume and volume index are routinely evaluated during echocardiographic assessment as having prognostic value in a wide range of cardiovascular pathologies. Yet, LA volume is easily affected by volume status. Thus, a non-invasive novel parameter such as indices of LA longitudinal strain (LS) have been proposed as alternative measurements. LA strain was shown to be associated with LV filling pressures and it has been suggested to provide prognostic information in patients with heart failure, atrial fibrillation, ischemic and valvular heart diseases. Nevertheless the acute effect of hemodynamic changes on LA LS indices is not well-established due to lack of evidence in healthy subjects and patient populations. The aim of this study is to evaluate the LA mechanics and change in echocardiographic methods used for assessment of LA by examining the end stage kidney patients before and after the hemodialysis (HD). Methods Patients between 18 and 85 years of age, receiving HD for at least 6 months were included. The echocardiographic images were obtained before and after HD. 2D speckle tracking strain analysis was performed for LA in 45 patients. Reference points for analysis are set on the "P" waves. LA reservoir, conduit and contraction phase LS were calculated. The changes in echocardiographic methods before and after hemodialysis were examined. Correlation between volume depletion and change in echocardiographic parameters were calculated. Results 45 patients (47.7 ± 14.7 years of age, 19 women) were included in study. The mean volume of ultrafiltration was 2755.12 ± 845.5 ml . The chamber sizes of LA are decreased after hemodialysis (LA diameter; 4.9 ± 0.8 cm vs. 4.4 ± 0.5 cm p Conclusion LA contraction LS is a volume independent measurement obtained by 2D speckle tracking. Assessment of LA mechanics with echocardiography would be an easy and repeatable assessment which can guide to describe the cardiac pathophysiology and hemodynamics better. Moreover defining novel volume independent parameters for evaluation of LA would contribute to clinical perspectives of the patients.
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- 2020
12. The impact of volume overload on right heart function in end-stage renal disease patients on hemodialysis
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Atiye Çengel, Özden Seçkin, Gökhan Gökalp, Serkan Ünlü, Selim Turgay Arınsoy, Nuri Bülent Boyacı, and Asife Sahinarslan
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Male ,medicine.medical_specialty ,Heart Ventricles ,medicine.medical_treatment ,Volume overload ,Hemodynamics ,Speckle tracking echocardiography ,Atrial Function, Right ,030204 cardiovascular system & hematology ,End stage renal disease ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Prospective Studies ,030212 general & internal medicine ,Atrium (heart) ,business.industry ,Middle Aged ,Echocardiography, Doppler ,Pathophysiology ,medicine.anatomical_structure ,Echocardiography ,Ventricle ,Ventricular Function, Right ,Cardiology ,Kidney Failure, Chronic ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business - Abstract
PURPOSE The aim of this study was to evaluate the impact of volume overload on echocardiographic parameters used for the assessment of the right ventricle (RV) and right atrium (RA), to determine volume-independent parameters and to noninvasively investigate the physio-mechanics of RV and RA by examining end-stage kidney patients before and after hemodialysis (HD). METHODS The echocardiographic images were obtained from 67 patients (49.2 ± 17.3 years, 23 f) before and after HD. Changes in echocardiographic parameters with HD were examined. The average ultrafiltrated volume was 3088.1 ± 1103.7 mL. RESULTS The size of RV and RA and tricuspid annular plane systolic excursion (TAPSE) decreased after HD, whereas myocardial performance index increased. RV fractional area change and iso-volumetric contraction acceleration time remained unchanged. RV global longitudinal strain (GLS) and RV early diastolic strain rate (SR) decreased after HD. Systolic and late diastolic SR of the RV showed no statistically significant difference after HD. Longitudinal strain and SR of RA contraction were not significantly different after HD. The changes in RV GLS (r = .641, P = .027), RV free wall longitudinal strain (r = .643, P
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- 2017
13. Neutrophil Gelatinase-Associated Lipocalin Level Can Predict Early Organ Damage in Primary Hypertensive Patients: A Pilot Study
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Serdar Gökhan Nurkoç, Serkan Ünlü, Bayram Şen, Atike Burçin Tefon, Murat Hasanreisoglu, and Asife Şahinarslan
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hypertension ,early organ damage ,diastolic dysfunction ,neutrophil gelatinase-associated lipocalin ,global longitudinal strain ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Early detection and treatment of complicated arterial hypertension will prevent its effect on the target organs. In line with this purpose, we aimed to reveal the prediction capability of neutrophil gelatinase-associated lipocalin to complicated hypertension. Methods: In total, 46 patients with hypertension and 21 healthy volunteers were included in the study. Left ventricle morphology and geometry, as systolic and diastolic functions, were analyzed. Global longitudinal strain was measured from recorded apical 3-chamber views. An ophthalmic examination was performed to investigate the presence of retinopathy in individuals with hypertension. In addition, plasma neutrophil gelatinase-associated lipocalin values were evaluated via the method of the enzyme-linked immunosorbent assay. Results: Both neutrophil gelatinase-associated lipocalin levels and global longitudinal strain percentages were statistically significant between the groups with diastolic dysfunction and the groups without diastolic dysfunction. Complicated hypertension was detected in 42 patients. Here, it was found that the neutrophil gelatinase-associated lipocalin level of 144.3 ng/mL predicted complicated hypertension with 0.872 sensitivity and 0.65 specificity values. Conclusion: Analyzing neutrophil gelatinase-associated lipocalin levels in patients with hypertension in routine practice can easily and practically detect complicated hypertension patients earlier.
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- 2023
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14. Effect of serum YKL-40 on coronary collateral development and SYNTAX score in stable coronary artery disease
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Adnan Abaci, Canan Demirtas, Ridvan Yalcin, Mehmet Kadri Akboga, and Asife Sahinarslan
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Male ,musculoskeletal diseases ,medicine.medical_specialty ,Collateral ,Collateral Circulation ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Severity of Illness Index ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Coronary Circulation ,Internal medicine ,Humans ,Medicine ,In patient ,Chitinase-3-Like Protein 1 ,Prospective Studies ,030212 general & internal medicine ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Syntax ,humanities ,Stenosis ,Cross-Sectional Studies ,medicine.anatomical_structure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Inflammatory biomarker ,Biomarkers ,Artery - Abstract
Many studies have revealed a role of YKL-40 as a new inflammatory biomarker in angiogenesis, inflammation, atherosclerosis and cardiovascular events. Thus, the aim of this study was to investigate the association of serum YKL-40 level with coronary collateral development and SYNTAX score in patients with stable coronary artery disease.A total of 165 patients who had ≥90% stenosis in at least one major coronary artery were prospectively enrolled in the study. Collateral degree was graded according to Rentrop-Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. The patients were also classified according to SYNTAX criteria, those with low (≤22) and those with high (22) SYNTAX score.Serum YKL-40 and hs-CRP levels were significantly lower in good collateral group. Furthermore, YKL-40 level showed significant positive correlations with SYNTAX score (r=0.486, p0.001) and hs-CRP level (r=0.340, p0.001). In multivariate regression analysis, serum YKL-40 (odds ratio: 0.928; 95% confidence interval: 0.917-0.940; p0.001), duration of ischemic symptom and total occlusion were independent predictors of good collateral development. In ROC curve analysis, a YKL-40 value cut-off point of ≥168.5 predicted the high SYNTAX score with a sensitivity of 81.0% and specificity of 72.4%.Increased serum YKL-40 level was related with poor collateral development and high SYNTAX score. According to these findings YKL-40 can be used as a predictor of good collateral development and high SYNTAX score.
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- 2016
15. Turkish Society of Cardiology consensus report on the rational use of cardiac troponins in daily practice
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Oğuz Yavuzgil, Bulent Gorenek, Semiha Emel Eryüksel, Ozlem Gulbahar, Beste Özben Sadıç, Aylin Yildirir, Asife Sahinarslan, Murtaza Emre Durakoğlugil, Ali Serdar Fak, Abdullah Tekin, Can Yücel Karabay, Kaan Okyay, and Ege Üniversitesi
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medicine.medical_specialty ,Cardiac troponin ,Turkey ,Turkish ,Cardiology ,Myocardial Ischemia ,MEDLINE ,Rational use ,Daily practice ,medicine ,Humans ,Myocardial infarction ,Practice Patterns, Physicians' ,Intensive care medicine ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,medicine.disease ,Troponin ,language.human_language ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,High sensitivity troponin ,Heart failure ,language ,InformationSystems_MISCELLANEOUS ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
PubMed ID: 31073114, [No abstract available]
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- 2019
16. Higher Ultrafiltration Rate is Associated with Right Ventricular Mechanical Dispersion
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Atiye Çengel, Gökhan Gökalp, Asife Sahinarslan, Serkan Ünlü, Burak Sezenöz, Efstathios D. Pagourelias, Orhan Uludag, and Turgay Arinsoy
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Male ,medicine.medical_specialty ,Longitudinal strain ,Ventricular Dysfunction, Right ,medicine.medical_treatment ,030232 urology & nephrology ,Ultrafiltration ,030204 cardiovascular system & hematology ,Diagnosis, Differential ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,right ,medicine ,Humans ,Statistical dispersion ,In patient ,mechanical ,Original Investigation ,business.industry ,Significant difference ,Middle Aged ,tracking ,ventricle ,medicine.anatomical_structure ,Tolerability ,Cardiovascular Diseases ,Echocardiography ,Ventricle ,Cardiology ,Kidney Failure, Chronic ,Female ,dispersion ,Hemodialysis ,speckle ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective Ultrafiltration rate is one of the major determinants of adverse outcomes in patients undergoing hemodialysis (HD) therapy. Previous studies have focused on the impact of HD on right ventricular (RV) peak strain values. However, the influence of HD on the temporal characteristics of deformation has not been reported yet. The aim of the present study was to evaluate the impact of high ultrafiltration rate (HUR) on RV mechanical dyssynchrony. Methods Echocardiographic images focused on the RV and left ventricle (LV) were obtained from 60 patients (49.2+-17.3 years, 22 female) before and after HD. Patients were divided into two groups according to ultrafiltration rate. Changes in echocardiographic parameters with HD were examined. Two-dimensional speckle-tracking strain analysis was used to assess deformation. Mechanical dispersion was measured as the standard deviation of time to peak longitudinal strain of six segments for RV and 18 segments for LV. Results The average ultrafiltrated volume and ultrafiltration rate were 3000.1+-1007.9 mL and 11.4+-2.9 mL/kg/h, respectively. Global longitudinal strain (GLS) of the RV and LV decreased after HD in both groups. A significant difference was observed in RV mechanical dispersion with HD for patients in the high ultrafiltration group. A mild statistically insignificant increase in LV mechanical dispersion was also observed after HD. Conclusion HUR has a substantial impact on LV and RV GLS and RV dyssynchrony. Ultrafiltration rates and volumes should be kept as low as possible to achieve hemodynamic stability and tolerability.
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- 2019
17. Relationship between serum vitamin D levels and angiographic severity and extent of coronary artery disease
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Yakup Alsancak, Atiye Çengel, Selçuk Özkan, Emrullah Kiziltunc, Aybüke Demir Alsancak, Ahmet Akyel, Asife Sahinarslan, Serkan Ünlü, Burak Sezenöz, Mehmet Kadri Akboga, Mehmet Ridvan Yalcin, and Sehri Elbeg
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Male ,Vitamin ,medicine.medical_specialty ,Clinical Biochemistry ,Comorbidity ,Coronary Artery Disease ,Coronary Angiography ,Severity of Illness Index ,Biochemistry ,Gastroenterology ,vitamin D deficiency ,Coronary artery disease ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,Severity of illness ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Aged ,Serum vitamin ,business.industry ,General Medicine ,Middle Aged ,Vitamin D Deficiency ,medicine.disease ,Surgery ,chemistry ,Cohort ,Female ,business - Abstract
Background Vitamin D is known for its effect in calcium and bone homeostasis. There is an increasing evidence for health benefits accomplished by activated vitamin D that go beyond these classical functions. Previous studies have suggested that lower vitamin D levels are associated with increased cardiovascular disease risk. Therefore, we aimed to evaluate relationship between vitamin D levels and extent and severity of coronary artery disease. Materials and methods A total of 746 patients in whom coronary angiography was performed between August 2012 and July 2013 were enrolled in this study. Serum vitamin D levels were measured, and patients were grouped according to their serum vitamin D levels (vitamin D 20 ng/dL (n = 144) Group 2). Gensini score system was used to evaluate the association between serum vitamin D levels and severity and extent of coronary artery disease. Results There was no significant difference between the groups in terms of baseline characteristics and demographic characteristics. Mean serum vitamin D levels of all patient cohort was 15·54 ± 7·46 ng/mL. Group 1 and Group 2 had an average serum vitamin D levels of 12·6 ± 3·3 ng/mL and 27·5 ± 7·8 ng/mL, respectively. Gensini score for all cohort was 26·25 ± 34·32. Group 1 had an average Gensini score of 26·4 ± 35·7; on the other hand, Gensini score was 25·5 ± 27·5 in Group 2 (P = 0·097). Conclusions This study failed to demonstrate significant relationship between serum vitamin D levels and the severity and extent of coronary artery disease. Further studies with more participation and homogenous groups with comparable individual and environmental features are needed to evaluate the association of serum vitamin D levels and cardiovascular diseases.
- Published
- 2015
18. Association of serum total bilirubin level with severity of coronary atherosclerosis is linked to systemic inflammation
- Author
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Adnan Abaci, Sinan Aydoğdu, Serdar Nurkoç, Yakup Alsancak, Asife Sahinarslan, Dursun Aras, Uğur Canpolat, and Mehmet Kadri Akboga
- Subjects
Adult ,Erythrocyte Indices ,Male ,medicine.medical_specialty ,Neutrophils ,Bilirubin ,Inflammation ,Coronary Artery Disease ,Coronary Angiography ,Systemic inflammation ,medicine.disease_cause ,Severity of Illness Index ,Gastroenterology ,Coronary artery disease ,chemistry.chemical_compound ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Lymphocyte Count ,Lymphocytes ,Neutrophil to lymphocyte ratio ,Coronary atherosclerosis ,Aged ,Retrospective Studies ,Chi-Square Distribution ,business.industry ,Red blood cell distribution width ,Middle Aged ,Protective Factors ,medicine.disease ,C-Reactive Protein ,Cross-Sectional Studies ,chemistry ,Multivariate Analysis ,Immunology ,Linear Models ,Female ,Inflammation Mediators ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Oxidative stress - Abstract
Although cardiovascular protective action of bilirubin has been attributed to its antioxidant effect, there was scarce data regarding the anti-inflammatory properties. Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD.Angiographic data of 1501 patients were analyzed in this retrospective cross-sectional study. Patients were categorized according to Gensini scores as control, mild CAD and severe CAD groups. The association of clinical and laboratory parameters with the severity of CAD were determined by multivariable linear regression analysis.Total bilirubin level in the control group was significantly higher than those of the other groups. After multivariable linear regression analysis total bilirubin [β=-3.131 (-4.481, -1.782), p0.001] was significantly associated with the severity of CAD. Futhermore, there was a moderate and significant inverse correlation between serum total bilirubin level and the severity of CAD (r=-0.173, p0.001), CRP (r=-0.112, p0.001), NLR (r=-0.070, p=0.026) and RDW (r=-0.074, p=0.027).Serum total bilirubin level was independently and inversely associated with the severity of coronary atherosclerosis in patients with stable CAD. In addition, total bilirubin level was inversely correlated with CRP, NLR and RDW. These results suggest that besides its already known effect on the oxidative stress, higher serum total bilirubin level may exhibit an anti-inflammatory effect in the coronary atherosclerotic process.
- Published
- 2015
19. Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients
- Author
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Hatice Pasaoglu, Turgay Arinsoy, Ozge Tugce Pasaoglu, Evsen Polattas Solak, Fatma Ayerden Ebinç, Sukru Sindel, Gülay Ulusal Okyay, Asife Sahinarslan, Kaan Okyay, and Ulver Derici
- Subjects
education.field_of_study ,medicine.medical_specialty ,Waist ,Triglyceride ,business.industry ,medicine.medical_treatment ,Population ,Hematology ,medicine.disease ,chemistry.chemical_compound ,Insulin resistance ,chemistry ,Intima-media thickness ,Nephrology ,Internal medicine ,medicine ,Cardiology ,Hemodialysis ,education ,business ,Body mass index ,Dialysis - Abstract
Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
- Published
- 2015
20. YKL-40 and other indicators of inflammation in coronary collateral development and SYNTAX score
- Author
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Asife Sahinarslan and Mehmet Kadri Akboga
- Subjects
Inflammation ,medicine.medical_specialty ,Syntax (programming languages) ,Collateral ,business.industry ,MEDLINE ,Collateral Circulation ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Collateral circulation ,03 medical and health sciences ,0302 clinical medicine ,Coronary Circulation ,030220 oncology & carcinogenesis ,Internal medicine ,Cardiology ,medicine ,Humans ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Published
- 2017
21. Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome
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Hatice Pasaoglu, Adnan Abaci, Mehmet Kadri Akboğa, Ridvan Yalcin, Asife Sahinarslan, and Canan Demirtas
- Subjects
Male ,musculoskeletal diseases ,medicine.medical_specialty ,Cross-sectional study ,Inflammation ,030204 cardiovascular system & hematology ,Gastroenterology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,White blood cell ,Severity of illness ,medicine ,Humans ,030212 general & internal medicine ,Chitinase-3-Like Protein 1 ,Prospective Studies ,Prospective cohort study ,National Cholesterol Education Program ,Metabolic Syndrome ,biology ,business.industry ,C-reactive protein ,medicine.disease ,medicine.anatomical_structure ,C-Reactive Protein ,Cross-Sectional Studies ,biology.protein ,Female ,medicine.symptom ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Editorial Comment ,Biomarkers - Abstract
OBJECTIVE Metabolic syndrome (MS) is defined by a cluster of interdependent physiological, biochemical, and clinical risk factors and linked to a state of chronic inflammation. YKL-40 is known as an inflammatory glycoprotein, which is secreted by various cell lines during inflammation. Thus, we aimed to assess the association of serum YKL-40 levels with the presence and severity of MS. METHODS In this prospective cross-sectional study, a total of 177 consecutive patients [n=114 MS present and n=63 MS absent] were enrolled. MS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. Serum YKL-40 and hs-CRP levels were measured for all participants. RESULTS Serum YKL-40, hs-CRP and white blood cell count (WBC) were significantly higher in the MS present group (p
- Published
- 2016
22. Dynamics of Concomitant Functional Mitral Regurgitation in Patients with Aortic Stenosis Undergoing TAVI
- Author
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Asife, Sahinarslan, Francesco, Vecchio, Philip, MacCarthy, Rafal, Dworakowski, Ranjit, Deshpande, Olaf, Wendler, and Mark, Monaghan
- Subjects
Original Article - Abstract
The aim of this study was to investigate the echocardiographic features of functional mitral regurgitation (MR) in patients with aortic stenosis (AS) pre- and post-trans catheter aortic valve implantation (TAVI).The study subjects consisted of 79 patients with severe AS, who underwent TAVI. The echocardiographic parameters related to MR severity prior to TAVI and the change in these parameters and MR severity within one month after implantation were retrospectively evaluated.The mean left ventricular ejection fraction (LVEF) was 53 ± 12%, and the mean MR severity was 1.2 ± 0.7. Among the baseline parameters, age (p = 0.019, r = 0.264), LV mass (p = 0.017, r = 0.269), deceleration time (DT) (p = 0.019, r = -0.266), left atrial diameter (p = 0.003, r = 0.325), were related to pre-procedure MR severity. After TAVI, the grade of MR (1.2 ± 0.7 vs. 0.8 ± 0.6, p0.001) and MR duration (43 ± 19% vs. 31 ± 23%, p0.001) were significantly decreased. The grade of pre-procedural MR (p0.001) was a predictor of residual MR after TAVI. However, there was not a significant change in the left ventricular echocardiographic parameters after TAVI [LVEF (53 ± 12 vs. 52 ± 11, p = 0.285), and LV mass (302 ± 84 vs. 306 ± 76 g, p = 0.495)].In patients with severe AS, functional MR is related to age, LV mass, DT and left atrial diameter. TAVI improves MR in these patients, even before LV remodelling occurs.
- Published
- 2016
23. Can ischemia modified albumin increase diagnostic power of myocardial perfusion scintigraphy?
- Author
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Asife Sahinarslan
- Subjects
lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Perfusion Imaging ,Serum albumin ,lcsh:Medicine ,Serum Albumin, Human ,Perfusion scanning ,Coronary artery disease ,Internal medicine ,Myocardial perfusion scintigraphy ,Humans ,Medicine ,ischemia modified albumin ,lcsh:RC31-1245 ,Serum Albumin ,biology ,business.industry ,lcsh:R ,Ischemia-modified albumin ,medicine.disease ,Cardiac Imaging Techniques ,myocardial perfusion scintigraphy ,lcsh:RC666-701 ,Cardiology ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,coronary artery disease - Published
- 2016
24. Relationship between plasma asymmetric dimethylarginine level and autonomic dysfunction in diabetic patients
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Atiye Çengel, Çağrı Yayla, Metin Arslan, Bulent Boyaci, Ahmet Akyel, Asife Sahinarslan, Sehri Elbeg, Yusuf Tavil, and Salih Topal
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Administration, Oral ,Arginine ,chemistry.chemical_compound ,Heart Rate ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Heart rate variability ,Endothelial dysfunction ,business.industry ,Type 2 Diabetes Mellitus ,Mean age ,Middle Aged ,medicine.disease ,Autonomic Nervous System Diseases ,Diabetes Mellitus, Type 2 ,chemistry ,Case-Control Studies ,Correlation analysis ,Electrocardiography, Ambulatory ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Asymmetric dimethylarginine ,business - Abstract
OBJECTIVES We aimed to investigate the relationship between plasma asymmetric dimethylarginine (ADMA) levels and heart rate variability (HRV) in diabetic patients. STUDY DESIGN The study included 100 patients (44 men, 56 women) with type 2 diabetes mellitus. The patients were divided into two groups based on the use of oral antidiabetics (n=67; mean age 54.6±7.8 years) or insulin (n=33; mean age 51.6±8.8 years). Plasma ADMA levels were measured and HRV parameters were calculated from 24-hour Holter EKG recordings. The findings were compared with those of a control group consisting of 42 nondiabetic individuals (mean age 52.8±6.2 years). RESULTS Compared to the control group, plasma ADMA levels were significantly higher (p=0.007) and all HRV parameters were significantly reduced in both diabetic groups. However, ADMA levels and HRV parameters were similar in the two diabetic groups (p>0.05). Correlation analysis showed no significant relationship between plasma ADMA levels and HRV parameters. CONCLUSION Our findings show that plasma ADMA levels are increased and HRV is reduced in diabetic patients, indicating that these patients have both endothelial dysfunction and autonomic dysfunction, but plasma ADMA levels cannot be used to evaluate autonomic dysfunction.
- Published
- 2012
25. The importance of fragmented QRS complexes in prediction of myocardial infarction and reperfusion parameters in patients undergoing primary percutaneous coronary intervention
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Aytun Çanga, Mustafa Çetin, İsmail Şahin, Asife Sahinarslan, Ömer Şatıroğlu, Turan Erdoğan, Yüksel Çiçek, Mehmet Bostan, Tuncay Kırış, Emre Durakoglugil, and Sinan Altan Kocaman
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Infarction ,Myocardial Reperfusion Injury ,Risk Assessment ,Lesion ,Electrocardiography ,Leukocyte Count ,QRS complex ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Internal medicine ,medicine ,Creatine Kinase, MB Form ,Humans ,cardiovascular diseases ,Myocardial infarction ,Aged ,Retrospective Studies ,biology ,business.industry ,Troponin I ,Percutaneous coronary intervention ,Electrocardiography in myocardial infarction ,Middle Aged ,medicine.disease ,Troponin ,Logistic Models ,Conventional PCI ,cardiovascular system ,biology.protein ,Cardiology ,Female ,Stents ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES The QRS complex fragmentations (fQRS) frequently seen on admission electrocardiograms (ECGs) with narrow or wide QRS complex are associated with increased morbidity and mortality. The causative relationship between fQRS and cardiac fibrosis is known, but the relation of fragmented QRS before and after primary percutaneous coronary intervention (p-PCI) with myocardial infarction and reperfusion parameters has not been studied until now. STUDY DESIGN The study included 184 consecutive patients with ST elevation myocardial infarction (STEMI) who underwent p-PCI. Presence or absence of fQRS on pre- and post-PCI ECGs and its change following PCI were investigated. In addition, independent predictors of fQRS were also investigated. Patients with significant organic valve disease and patients having any QRS morphology with QRS duration ?120 ms as well as patients with permanent pacemakers were excluded from the study. RESULTS Patients with fQRS on admission ECG had higher leukocyte counts (p=0.001), higher CK-MB (p=0.001) and troponin levels (p=0.005), increased pain to balloon time (p=0.004), higher Killip score (p
- Published
- 2012
26. Neutrophil Gelatinase-Associated Lipocalin Levels in Isolated Coronary Artery Ectasia
- Author
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Neslihan Bukan, Ummugulsum Yıldız, Asife Sahinarslan, Ahmet Akyel, Yakup Alsancak, Emrullah Kiziltunc, Mehmet Kadri Akboga, Murat Özdemir, Salih Topal, and Çağrı Yayla
- Subjects
Male ,medicine.medical_specialty ,Connective tissue ,Enzyme-Linked Immunosorbent Assay ,Lipocalin ,Coronary Angiography ,Gastroenterology ,Basal (phylogenetics) ,Lipocalin-2 ,Proto-Oncogene Proteins ,Internal medicine ,Ectasia ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,business.industry ,Coronary artery ectasia ,Coronary Aneurysm ,Middle Aged ,medicine.disease ,Coronary Vessels ,Lipocalins ,Pathophysiology ,Coronary arteries ,Endocrinology ,medicine.anatomical_structure ,Disease Progression ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Acute-Phase Proteins ,Follow-Up Studies - Abstract
Background The pathophysiology of coronary artery ectasia (CAE) is still unknown. Inflammation and degradation of connective tissue may have a role in the development of coronary ectasia. In the present study, the authors examined neutrophil gelatinase-associated lipocalin (NGAL) levels in isolated CAE patients. Methods Thirty-five patients with isolated CAE (25 males; mean age, 59 ± 10 years) and 35 age- and sex-matched healty volunteers (22 males; mean age, 57 ± 11 years) who had been shown to have normal coronary arteries were included in the study. Basal characteristics were recorded. Serum NGAL levels were determined with an enzyme-linked immunosorbent assay kit. Results NGAL levels were significantly higher in the isolated CAE group than in the control group (65.1 ± 13 vs 53.7 ± 19 ng/mL; P = 0.006). There were also significant difference in NGAL levels according to the number of ectatic coronary arteries (58.1 ± 13, 70.9 ± 9, and 71.1 ± 11 ng/mL for 1, 2, and 3 arteries, respectively; P = 0.015). Level of NGAL was lowest in patients who have only 1 ectatic coronary artery. Conclusion Serum NGAL levels increased in patients with isolated CAE, and NGAL may play a crucial role in the development and/or progression of coronary artery ectasia.
- Published
- 2011
27. The Relationship of Serum Erythropoietin Level With Coronary Collateral Grade
- Author
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Atiye Çengel, Asife Sahinarslan, Sinan Altan Kocaman, Ugur Ercin, Ali Cevat Tanalp, Neslihan Bukan, Salih Topal, Ridvan Yalcin, and Bulent Boyaci
- Subjects
Male ,Serum erythropoietin ,medicine.medical_specialty ,Collateral ,Collateral Circulation ,Coronary Angiography ,Angina ,Neovascularization ,chemistry.chemical_compound ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Angina, Stable ,Erythropoietin ,Oxygen saturation (medicine) ,Vascular Endothelial Growth Factors ,business.industry ,Middle Aged ,medicine.disease ,Collateral circulation ,Surgery ,Vascular endothelial growth factor ,chemistry ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Erythropoietin has been shown to induce neovascularization and protect against ischemic vascular injury. We investigated whether a higher serum erythropoietin (EPO) level is related to better coronary collateral vessel grade.Ninety-nine patients with stable angina pectoris who have at least 1 coronary stenosis of equal to or greater than 70% at coronary angiography were prospectively enrolled. Serum EPO and vascular endothelial growth factor (VEGF) levels were studied. Coronary collateral degree was graded according to the Rentrop method. Patients with grade 2-3 collateral degree were included in the good collateral group and formed Group I. The patients with grade 0-1 collateral degree were included in the poor collateral group and formed Group II.The serum EPO level was significantly higher in the good collateral group (17.3 ± 9.3 mU/mL vs 11.7 ± 5.0 mU/mL; P0.001). There was also a positive correlation between serum EPO level and Rentrop score (r = 0.39; P0.001). In multivariate analysis, serum EPO level (odds ratio [OR] 1.336; 95% confidence interval [CI], 1.120-1.593; P = 0.001), oxygen saturation (OR 0.638; 95% CI, 0.422-0.963; P = 0.033) and presence of chronic total occlusion (CTO) (OR 26.7; 95% CI, 3.874-184.6; P = 0.001) were independently related to well-developed coronary collaterals.Higher serum EPO level is related to better coronary collateral development. Erythropoietin may have a positive effect on the development of collaterals and may provide a new agent for the treatment strategies to enhance coronary collateral vessel development.
- Published
- 2011
28. The relation of serum monocyte chemoattractant protein-1 level with coronary atherosclerotic burden and collateral degree in stable coronary artery disease
- Author
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Sinan Altan Kocaman, Salih Topal, Timur Timurkaynak, Neslihan Bukan, Asife Sahinarslan, and Ugur Ercin
- Subjects
Male ,Coronary angiography ,medicine.medical_specialty ,Collateral Circulation ,Coronary Artery Disease ,Coronary Angiography ,Severity of Illness Index ,Stable angina ,Coronary artery disease ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,In patient ,Normal coronary arteries ,Chemokine CCL2 ,Coronary atherosclerosis ,business.industry ,Mean age ,Middle Aged ,medicine.disease ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Monocyte chemoattractant protein - Abstract
OBJECTIVES We investigated whether serum monocyte chemoattractant protein-1 (MCP-1) level predicted coronary atherosclerotic burden in patients with stable coronary artery disease and its relationship with coronary collateral grade. STUDY DESIGN We prospectively included 196 patients (103 males, 93 females; mean age 59 ± 11 years) who underwent coronary angiography for stable angina pectoris. Serum MCP-1 levels were determined before coronary angiography. Coronary atherosclerotic burden was measured by the Gensini score, and coronary collateral development was assessed by the Rentrop classification. The patients were divided into four groups: those with normal coronary arteries (NCA); those with coronary lesions of
- Published
- 2011
29. Plasma osteopontin levels in prediction of prognosis in acute myocardial infarction
- Author
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Yusuf Tavil, Gülten Taçoy, Kaan Okyay, Ozlem Gurbahar, Nihat Sen, Asife Sahinarslan, Atiye Çengel, Ridvan Yalcin, Deniz Demirkan, Bulent Boyaci, and Murat Turfan
- Subjects
Male ,medicine.medical_specialty ,Myocardial Infarction ,Risk Assessment ,Gastroenterology ,Statistics, Nonparametric ,stomatognathic system ,Predictive Value of Tests ,Internal medicine ,Natriuretic Peptide, Brain ,Troponin I ,Healthy control ,Humans ,Medicine ,cardiovascular diseases ,Osteopontin ,Myocardial infarction ,Chi-Square Distribution ,biology ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,Control subjects ,medicine.disease ,Peptide Fragments ,surgical procedures, operative ,Endocrinology ,Echocardiography ,Case-Control Studies ,Creatinine ,biology.protein ,Female ,Creatine kinase ,Peak value ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Mace - Abstract
We sought to explain the clinical importance of the osteopontin (OPN) in the setting of acute ST-elevation myocardial infarction (STEMI).Eighty consecutive patients (55 = 11 years, 12 women and 68 men) and sixty healthy control subjects were included in the study. In all patients, plasma OPN levels were assessed on admission and on the third day (peak value). Creatinine kinase (CK)/CK-myocardial band (MB), troponin I and N-terminal pro-brain natriuretic factor levels and echocardiographic findings were also recorded. Patients were classified into high and low OPN groups according to the median OPN value, and monitored for the occurrence of major adverse cardiovascular events (MACE).Patients with STEMI had higher OPN levels (23.8 [16.7-41.3] ng/ml) on admission than the control subjects (18.0 [11.3-31.5] ng/ml, P = 0.004).The third day value of OPN was significantly higher (39.2 [27.2-56.0] ng/ml) than the OPN level on admission (23.8 [16.7-41.3] ng/ml, P0.001). Admission and peak OPN levels were not correlated with CK/CK-MB, white blood cell counts, troponin I and the N-terminal pro-brain natriuretic factor. The plasma OPN levels were not correlated with left ventricular wall motion score index either. In the subgroups of infarct localization and reperfusion strategy, plasma OPN levels were similar. When the patients were compared according to the median OPN values, there were no differences in the occurrence of MACE between the high and low OPN groups.This study suggests, for the first time, that the plasma OPN level increases in the first hours of the acute STEMI; however, it could not be used as a prognostic biomarker of STEMI.
- Published
- 2011
30. The impact of multiple vessel disease on fractional flow reserve
- Author
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Sinan Altan Kocaman, Fatma Hizal, Asife Sahinarslan, and Timur Timurkaynak
- Subjects
Male ,medicine.medical_specialty ,Coronary Artery Disease ,Fractional flow reserve ,Severity of Illness Index ,Coronary artery disease ,Lesion ,Internal medicine ,Severity of illness ,medicine ,Humans ,Retrospective Studies ,Analysis of Variance ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Coronary Vessels ,Fractional Flow Reserve, Myocardial ,Coronary arteries ,Stenosis ,medicine.anatomical_structure ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Pericardium ,Artery - Abstract
Background - Fractional flow reserve (FFR) is a method for the assessment of intermediate lesions.The impact of lesions at other coronary arteries on the FFR is not clear. We aimed to investigate the impact of the lesions in the other coronary arteries on FFR measurement. Method - FFR was performed in II3 patients with intermediate lesions at the left anterior descending artery. FFR values at baseline (FFRbase) and after adenosine administration (FFRmin) were detected.We divided the patients into groups according to FFRmin value. The first group consisted of 52 patients with a FFR < 0.80 and the second group consisted of 61 patients with a FFR ≥ 0.80. We investigated the relationship between Gensini score and FFR values within the groups. Results - A significant negative correlation was found in the analysis comparing Gensini score with FFRbase and FFRmin among the first group (r = -0.248, P = 0.009 and r = -0.685, P < 0.001, respectively). The relative FFR ratio was also significantly related with the Gensini score in the first group (r = -210, P = 0.047).When we divided the patients into 3 subgroups according to the number of the coronary arteries with significant lesion (≥ 70% stenosis) (group I: I vessel, group II: 2 vessels, group III: 3 vessels), we observed a relation with FFRbase (0.89±0.05 vs. 0.87 ±0.06 vs. 0.81 ± 0.09, respectively, P = 0.007) and FFRmin (0.76 ± 0.04 vs. 0.75 ± 0.05 vs. 0.68 ± 0.I respectively, P= 0.002). In the second group, there was no relationship between Gensini score, FFR values and number of significantly diseased vessels. Conclusion - The overall extent and severity of coronary artery disease in a patient may affect the FFR measurement and may lead to misinterpretation of the lesion severity.
- Published
- 2009
31. Brain natriuretic peptide correlates with troponin T in patients with renal failure
- Author
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Kaan Okyay, Atiye Çengel, Sukru Sindel, Musa Bali, Nihan Torer, Galip Guz, and Asife Sahinarslan
- Subjects
Adult ,Male ,medicine.medical_specialty ,Volume overload ,urologic and male genital diseases ,Left ventricular hypertrophy ,Troponin T ,Troponin complex ,Predictive Value of Tests ,Renal Dialysis ,Internal medicine ,Natriuretic Peptide, Brain ,Humans ,Medicine ,In patient ,Prospective Studies ,cardiovascular diseases ,Aged ,Analysis of Variance ,Ejection fraction ,business.industry ,Stroke Volume ,General Medicine ,Middle Aged ,Brain natriuretic peptide ,medicine.disease ,cardiovascular system ,Cardiology ,Kidney Failure, Chronic ,Regression Analysis ,Chronic renal failure ,Female ,Hypertrophy, Left Ventricular ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
In patients with chronic renal failure, the main cause of mortality is cardiovascular disease. Cardiac troponin T (cTnT) and brain natriuretic peptide (BNP) are found to be related with decreased survival in both the normal population and in patients with chronic renal failure in different studies. Our aim is to investigate the relationship between cTnT and BNP in patients with chronic renal failure.58 chronic haemodialysis patients were enrolled prospectively for the study. Blood samples for measurement of cTnT and BNP were collected after the haemodialysis. The patients are divided into 3 groups according to cTnT measurements. Group I included the patients with cTnT0.05 ng/ml, Group II included the patients with cTnT between 0.05 and 0.1 ng/ml and group III included the patients with cTnT0. 1 ng/ml. We performed echocardiography in all patients to measure the left ventricular ejection fraction and thickness of septum and posterior wall. When BNP levels were compared among the 3 groups, we found that the BNP level was lowest in group I and highest in group III (165.13 +/- 125.44 pg/dl; 236.0 +/- 107.83 pg/dl; 280.71 +/- 153.25 pg/dl, respectively) (P = 0.01).The difference in BNP levels among groups was statistically significant and independent from left ventricular hypertrophy, left ventricular ejection fraction and volume overload in multiple regression analysis. We also searched the relationship between plasma cTnT and BNP levels and found a positive correlation (r = 0.3; P = 0.023).cTnT and BNP levels were related to each other in patients with chronic renal failure.These parameters can help to identify the patients with a high risk for cardiovascular diseases.
- Published
- 2007
32. [Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis]
- Author
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Çağrı Yayla, Dursun Aras, Sinan Aydoğdu, Uğur Canpolat, Mehmet Kadri Akboga, Serkan Cay, Asife Sahinarslan, Adnan Abaci, Serkan Topaloglu, and Kadri Açıkgöz
- Subjects
Adult ,Erythrocyte Indices ,Male ,medicine.medical_specialty ,lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,red cell distribution width ,mitral valve stenosis ,rheumatic mitral stenosis ,Heart valve stenosis ,lcsh:Medicine ,Mitral valve stenosis ,Left atrial ,Internal medicine ,Healthy control ,medicine ,Humans ,Mitral Valve Stenosis ,In patient ,lcsh:RC31-1245 ,business.industry ,lcsh:R ,Rheumatic Heart Disease ,Red blood cell distribution width ,Middle Aged ,medicine.disease ,Stenosis ,inflammation ,lcsh:RC666-701 ,Baseline characteristics ,Case-Control Studies ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: As an indicator of variability in circulating erythrocyte size, red cell distribution width (RDW) is linked to chronic inflammation. The association of rheumatic heart valve stenosis and inflammation is also well-known. This study aimed to assess the relationship between RDW and presence and severity of rheumatic mitral valve stenosis (RMVS). Methods: A total of 417 consecutive patients with RMVS, and 81 age- and -gender matched healthy control subjects were included in the study between February 2009 and April 2014. Transthoracic echocardiography and demographic characteristics were recorded for all participants. Results: Baseline characteristics were similar in the two groups. However, median RDW was significantly higher in patients with RMVS compared to control group (14.4% [11.3- 19.6] vs. 13.6% [11.6-18.1], p
- Published
- 2015
33. ASSOCIATION OF SERUM TOTAL BILIRUBIN LEVEL WITH SEVERITY OF CORONARY ATHEROSCLEROSIS IS LINKED TO SYSTEMIC INFLAMMATION: PROMISING RESULTS FROM A LARGE SCALE COHORT STUDY
- Author
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Serdar Nurkoç, Sinan Aydoğdu, Yakup Alsancak, Adnan Abaci, Dursun Aras, Uğur Canpolat, Mehmet Kadri Akboga, and Asife Sahinarslan
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Serum total bilirubin level ,Immunology ,medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Systemic inflammation ,business ,Gastroenterology ,Coronary atherosclerosis ,Cohort study - Published
- 2015
34. Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients
- Author
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Gülay, Ulusal Okyay, Kaan, Okyay, Evşen, Polattaş Solak, Asife, Sahinarslan, Özge, Paşaoğlu, Fatma, Ayerden Ebinç, Hatice, Paşaoğlu, Ülver, Boztepe Derici, Şükrü, Sindel, and Turgay, Arınsoy
- Subjects
Male ,Cross-Sectional Studies ,Adipose Tissue ,Cardiovascular Diseases ,Echocardiography ,Renal Dialysis ,Risk Factors ,Humans ,Female ,Middle Aged ,Pericardium - Abstract
Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P 0.001), waist circumference (β = 0.572, P 0.001), body fat mass (β = 0.562, P 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = -0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high-density lipoprotein cholesterol ratio (β = 0.529, P 0.001), 1/HOMA-IR (β = -0.386, P = 0.006), and spKt/V (β = -0.311, P = 0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
- Published
- 2015
35. The Assessment of Atrial Electromechanical Delay in Patients With Acromegaly
- Author
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Cigdem Ozkan, Alev Eroglu Altinova, Uğur Canpolat, Mehmet Kadri Akboga, Bulent Boyaci, Azmi Eyiol, Kadriye Gayretli Yayla, Asife Sahinarslan, and Çağrı Yayla
- Subjects
Male ,medicine.medical_specialty ,Doppler echocardiography ,Independent predictor ,Doppler imaging ,Electrocardiography ,Internal medicine ,Bayesian multivariate linear regression ,Acromegaly ,medicine ,Humans ,In patient ,Heart Atria ,Atrial Premature Complexes ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Atrial Function ,Echocardiography, Doppler ,Endocrinology ,Cardiology ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
We aimed to evaluate whether atrial electromechanical delay (AEMD) measured by tissue Doppler imaging (TDI), which is an indicator for structural and electrical remodelling of the atria, is prolonged in patients with active or inactive acromegaly, or both, compared with a control group.A total of 34 patients with acromegaly (18 active/16 inactive) and 35 patients as a control group were enrolled. Both intra- and inter-AEMD were calculated by TDI. The correlation between clinical variables and AEMD were analyzed.Both inter-AEMD and right and left intra-AEMD were prolonged in patients with acromegaly compared with the control group (P0.001, P0.001, and P = 0.004, respectively). Also, patients with active acromegaly showed higher inter-AEMD and right intra-AEMD compared with patients with inactive acromegaly (P0.05). There was no significant difference in left intra-AEMD between patients with active acromegaly and those with inactive acromegaly (P = 0.977). The growth hormone and insulin-like growth factor (IGF-1) levels positively correlated with inter-AEMD (r = 0.577; P0.001; r = 0.614; P0.001, respectively). Additionally, we found that inter-AEMD was significantly and positively correlated with relationship between maximal values of passive mitral inflow (E, PW-Doppler) and lateral early diastolic mitral annular velocities (e', TDI) (r = 0.316; P = 0.008). Only the serum IGF-1 level was independently associated with inter-AEMD in multivariate linear regression analysis (β = 0.500; P = 0.011).Our study findings showed that both inter- and intra-AEMD are prolonged in patients with acromegaly. Also, AEMD was observed to be more prolonged in patients with active acromegaly than in those with inactive acromegaly. IGF-1 was an independent predictor of inter- AEMD in patients with acromegaly. Being a noninvasive, inexpensive, and simple technique, AEMD may be used as an indicator for atrial electrical and structural remodelling in patients with acromegaly.
- Published
- 2015
36. Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography
- Author
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Asife Sahinarslan, Atiye Çengel, Sedat Türkoğlu, Alev Hasanoglu, Timur Timurkaynak, and Gürsel Biberoğlu
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Adolescent ,Arginine ,Coronary Artery Disease ,Coronary Angiography ,Severity of Illness Index ,Angina Pectoris ,Coronary artery disease ,Lesion ,chemistry.chemical_compound ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Endothelial dysfunction ,Prospective cohort study ,Aged ,business.industry ,fungi ,food and beverages ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,chemistry ,Coronary vessel ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Asymmetric dimethylarginine ,business - Abstract
BACKGROUND: Given that the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, can decrease nitric oxide bioavailability and lead to atherosclerosis, its concentration can be a good predictor for coronary artery disease. In this study, we investigated the relationship of plasma asymmetric dimethylarginine concentration with lesion distribution and severity at coronary artery angiography. METHOD: Ninety-eight patients with stable angina were enrolled prospectively. We divided the patients into two groups. Group I (n=37) included the patients with normal coronary arteries. All the other patients were included in group II (n=61). We calculated coronary atherosclerotic score and coronary vessel score. Plasma asymmetric dimethylarginine, L-arginine and symmetric dimethylarginine concentrations were measured and L-arginine/asymmetric dimethylarginine ratio was calculated. RESULTS: Plasma L-arginine and symmetric dimethylarginine concentrations did not differ in the two groups. The plasma asymmetric dimethylarginine level, however, was higher in group II patients than in group I patients (0.43+/-0.26 vs. 0.59+/-0.28 micromol/l, P=0.004) and L-arginine/asymmetric dimethylarginine ratio was lower in group II patients than in group I patients (262.0+/-186.4 vs. 176.6+/-139.8, P=0.019). Asymmetric dimethylarginine was positively correlated with the coronary atherosclerotic score (rs=0.273, P=0.006). Moreover, asymmetric dimethylarginine was an important predictor of angiographically defined coronary artery disease (odds ratio=14.42, P=0.004). CONCLUSION: Our findings support the hypothesis that the plasma asymmetric dimethylarginine concentration may be a good indicator of predicting coronary artery disease.
- Published
- 2006
37. Markers of early atherosclerosis, oxidative stress and inflammation in patients with acromegaly
- Author
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Duygu Sahin, Fusun Balos Toruner, Ethem Turgay Cerit, Aylin Sepici Dinçel, Cigdem Ozkan, Çağrı Yayla, Metin Arslan, Mujde Akturk, Asife Sahinarslan, and Alev Eroglu Altinova
- Subjects
Adult ,Male ,medicine.medical_specialty ,Carotid Artery, Common ,Endocrinology, Diabetes and Metabolism ,Inflammation ,Vasodilation ,HMGB1 ,medicine.disease_cause ,Carotid Intima-Media Thickness ,Endocrinology ,Risk Factors ,Internal medicine ,Acromegaly ,medicine ,Humans ,cardiovascular diseases ,HMGB1 Protein ,Adiposity ,biology ,business.industry ,Case-control study ,Middle Aged ,medicine.disease ,Atherosclerosis ,Lipoproteins, LDL ,Oxidative Stress ,C-Reactive Protein ,Intima-media thickness ,Adipose Tissue ,Case-Control Studies ,cardiovascular system ,biology.protein ,Female ,medicine.symptom ,Inflammation Mediators ,business ,Body mass index ,Pericardium ,Oxidative stress ,Biomarkers - Abstract
Data regarding atherosclerosis in acromegaly is controversial in literature. We aimed to investigate the markers of early atherosclerosis, oxidative stress, inflammation and their relationships with each other in acromegaly.Thirty-nine patients with acromegaly and 40 control subjects were enrolled. Patients were classified into two groups; active acromegaly (AA) and controlled acromegaly (CA). Controls were matched by age, gender, body mass index and presence of cardiovascular risk factors. Flow mediated dilatation (FMD), carotid intima media thickness (CIMT), epicardial adipose tissue thickness (EAT) were measured and serum levels of oxidative stress parameters, high mobility group box 1 protein (HMGB1) and high sensitive CRP (hs CRP) were evaluated.Significantly decreased FMD, increased CIMT and EAT were found in patients with acromegaly compared to controls (p 0.01, p 0.05, p 0.001, respectively). EAT correlated negatively with FMD (r = -0.24, p = 0.038) and positively with CIMT (r = 0.37, p 0.01). Presence of acromegaly, hypertension and age were found to be the predictors of early atherosclerosis (p 0.05). Hs CRP was decreased in AA compared to controls (p = 0.01). There were no significant differences for HMGB1 and oxidized LDL (ox-LDL) cholesterol levels and total antioxidant capacity (TAC) between AA, CA and controls (p 0.05).Early atherosclerosis measured with FMD, CIMT and EAT may exist in acromegaly. However, decreased hs CRP and unchanged HMGB1, ox-LDL and TAC levels suggest that inflammation and oxidative stress do not seem to contribute to the development of atherosclerosis in these patients.
- Published
- 2014
38. Neutrophil-to-lymphocyte ratio is increased in patients with rheumatic mitral valve stenosis?
- Author
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Yakup Alsancak, Gokhan Gokalp, Mehmet Kadri Akboga, Çağrı Yayla, Asife Sahinarslan, Serdar Nurkoç, Adnan Abaci, and Ahmet Akyel
- Subjects
Male ,medicine.medical_specialty ,Neutrophils ,rheumatic mitral valve disease ,Systemic inflammation ,C-reactive protein ,Basal (phylogenetics) ,Mitral valve stenosis ,Predictive Value of Tests ,neutrophil-to-lymphocyte ratio ,Internal medicine ,medicine ,Humans ,Mitral Valve Stenosis ,Lymphocytes ,Neutrophil to lymphocyte ratio ,Retrospective Studies ,Original Investigation ,biology ,business.industry ,fungi ,Cholesterol, HDL ,Rheumatic Heart Disease ,Retrospective cohort study ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Cholesterol ,ROC Curve ,inflammation ,Predictive value of tests ,Cardiology ,biology.protein ,Population study ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVE The role of systemic and chronic inflammatory processes in the pathophysiology of rheumatic heart valve disease is well known. The neutrophil-to-lymphocyte ratio (NLR) was shown to be an indicator of systemic inflammation. In this study, we aimed to investigate relationship between NLR as a marker of systemic inflammation and rheumatic mitral valve stenosis (RMVS). METHODS This is a retrospective study. Among patients who underwent transthoracic echocardiography between January 2008-March 2013, 314 patients with RMVS were included retrospectively in the study. The control group included 57 healthy persons who underwent transthoracic echocardiography during the study period. Basal characteristics and NLR were compared between the two groups. Independent predictors of RMVS were determined by logistic regression analysis. RESULTS Basal characteristics were similar among the groups (age, 50.2 ± 14.2 vs. 49.2 ± 13.0, p=0.60). The NLR was significantly higher in patients with RMVS [2.9 (0.6-13.0) vs. 2.1 (0.7-5.8), p
- Published
- 2014
39. Elevated Cardiac Troponin T in Hemodialysis Patients Receiving More Intravenous Iron Sucrose
- Author
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Kadriye Altok Reis, Ridvan Yalcin, Oktay Bagdatoglu, Musa Bali, Mustafa Kavutcu, Galip Guz, Asife Sahinarslan, Sukru Sindel, and Annemieke Dhondt
- Subjects
Male ,medicine.medical_treatment ,Coronary Artery Disease ,Kidney Function Tests ,Critical Care and Intensive Care Medicine ,Ferric Compounds ,Severity of Illness Index ,Gastroenterology ,Glucaric Acid ,chemistry.chemical_compound ,Troponin complex ,Reference Values ,Prospective Studies ,Infusions, Intravenous ,Blood urea nitrogen ,Aged, 80 and over ,Ferric Oxide, Saccharated ,biology ,Troponin T ,Incidence ,General Medicine ,Middle Aged ,Combined Modality Therapy ,Survival Rate ,Treatment Outcome ,Nephrology ,Disease Progression ,Female ,Hemodialysis ,Adult ,medicine.medical_specialty ,Adolescent ,Renal function ,Risk Assessment ,Sensitivity and Specificity ,Statistics, Nonparametric ,Age Distribution ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Sex Distribution ,Aged ,Creatinine ,Chi-Square Distribution ,Dose-Response Relationship, Drug ,business.industry ,Surgery ,Ferritin ,chemistry ,Case-Control Studies ,biology.protein ,Kidney Failure, Chronic ,Creatine kinase ,business ,Biomarkers ,Blood Chemical Analysis ,Follow-Up Studies - Abstract
Elevated cardiac troponin T (cTnT) has been associated with shorter survival in hemodialysis patients. Moreover, intravenous (IV) iron treatment has been held responsible for oxidative stress and accelerated atherosclerosis in these patients. In the present study, we investigated the relationship between cTnT concentration, IV iron treatment, and parameters of iron status. In addition, parameters of oxidative stress, inflammation, and atherosclerosis were evaluated. Predialysis blood samples of 78 chronic hemodialysis patients were analyzed for cTnT, malondialdehyde, creatine kinase (CK), and CK-isoenzyme MB (CK-MB). In addition, the mean value of predialysis serum samples collected during the last year, were considered for homocysteine, ferritin, iron, iron binding capacity, blood cell counts, blood urea nitrogen, creatinine, albumin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), calcium, phosphate, iPTH, cholesterol, and triglyceride. The quantity of IV iron sucrose administered during the last two years was counted from the patients' files. Echocardiography, all events related to ischemic heart disease, and urine volume were also recorded. Elevated cTnT levels (greater than or equal to 0.10 ng/mL) were found in 18 patients (23.1%). The amount of iron administered was 2264 +/- 1871 mg with a range 0-7000 mg. Patients with elevated cTnT levels received more IV iron than those with normal cTnT (3692 +/- 1771 vs. 1761 +/- 1595 mg, p
- Published
- 2004
40. OP-050 Increased Serum Ykl-40 Level is Associated with the Presence and Severity of Metabolic Syndrome
- Author
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Hatice Pasaoglu, Mehmet Kadri Akboga, Asife Sahinarslan, Canan Demirtas, Adnan Abaci, and Ridvan Yalcin
- Subjects
medicine.medical_specialty ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cardiology ,Medicine ,030212 general & internal medicine ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
41. Fungal endocarditis involving rheumatic mitral valve in a young man
- Author
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Yusuf Tavil, Asife Sahinarslan, Ahmet Akyel, Bulent Boyaci, and Mehmet Kadri Akboga
- Subjects
Rheumatic mitral valve ,medicine.medical_specialty ,business.industry ,Fungal endocarditis ,medicine.disease ,Article ,Cushing syndrome ,medicine.anatomical_structure ,Internal medicine ,Mitral valve ,Cardiology ,Medicine ,business ,Cardiology and Cardiovascular Medicine - Abstract
Fungal endocarditis is a relatively rare condition with particular difficulties in diagnosis and treatment. These difficulties lead to higher rates of mortality and morbidity. We report the successful treatment of a patient with rheumatic mitral valve who had fungal endocarditis due to Cushing syndrome caused by iatrogenic corticosteroid supplement. © 2011 Japanese College of Cardiology.
- Published
- 2011
- Full Text
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42. OP-074 Association of Red Blood Cell Distribution Width with The Presence and Severity of Rheumatic Mitral Valve Stenosis
- Author
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Çağrı Yayla, Dursun Aras, Adnan Abaci, Kadri Açıkgöz, Uğur Canpolat, Mehmet Kadri Akboga, Serkan Cay, Serkan Topaloglu, Sinan Aydoğdu, and Asife Sahinarslan
- Subjects
medicine.medical_specialty ,Mitral valve stenosis ,business.industry ,Internal medicine ,medicine ,Cardiology ,Red blood cell distribution width ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease - Published
- 2015
43. OP-195 The Relationship of Coronary Artery Disease with Alleles of Chromosome 9p21 in Turkish Population
- Author
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Sevda Menevse, Ata Bolayır, Çağrı Yayla, Azmi Eyiol, Atiye Seda, Burak Sezenöz, Kaan Okyay, Atiye Çengel, Asife Sahinarslan, and Akin Yilmaz
- Subjects
Coronary artery disease ,medicine.medical_specialty ,Turkish population ,business.industry ,Internal medicine ,medicine ,Cardiology ,Chromosome ,Allele ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2015
44. Comparison of radiation-induced damage between CT angiography and conventional coronary angiography
- Author
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Asife Sahinarslan, Mehmet Ali Ergun, Sinan Altan Kocaman, Mehmet Araç, Derya Kan Karaer, Ahmet Akyel, Duygu Bas, Bulent Boyaci, and Gonca Erbaş
- Subjects
Male ,musculoskeletal diseases ,Sister chromatid exchange ,Computed tomography ,Coronary Angiography ,Effective dose (radiation) ,Angina ,Multidetector Computed Tomography ,parasitic diseases ,Humans ,Medicine ,Angina, Stable ,Prospective Studies ,cardiovascular diseases ,Radiation Injuries ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,fungi ,Dose-Response Relationship, Radiation ,DNA ,General Medicine ,Middle Aged ,medicine.disease ,Coronary arteries ,Dose–response relationship ,medicine.anatomical_structure ,Angiography ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Sister Chromatid Exchange ,DNA Damage - Abstract
OBJECTIVE Both computed tomography (CTA) and conventional angiography (CCA) can provide direct visualization of the coronary arteries. The aim of the present study was to compare the radiation exposure between CTA and CCA and to search whether this amount of radiation causes significant DNA damage. METHOD Seventy-two patients who underwent CTA or CCA were enrolled prospectively. We recorded the radiation dosage that was used during the procedures and calculated the effective dose (ED). We determined the sister chromatid exchange (SCE) level from the blood samples which were drawn from the patients before and after the procedures. The change in SCE is used as the measure of DNA damage induced by the radiation. RESULTS The patients in the CTA (n = 36) and CCA groups (n= 36) had similar baseline characteristics. The ED was higher in CTA examinations compared to CCA examinations (14.2 +/- 2.7 vs 6.4 +/- 3.1, P
- Published
- 2013
45. [Cardiac computed tomography and radiation]
- Author
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Burak Sezenöz and Asife Sahinarslan
- Subjects
Heart Defects, Congenital ,medicine.medical_specialty ,medicine.diagnostic_test ,Cardiac computed tomography ,business.industry ,Computed tomography ,Radiation Dosage ,Diagnosis, Differential ,X ray computed ,Internal medicine ,Cardiology ,Medicine ,Humans ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Radiation Injuries ,Tomography, X-Ray Computed - Abstract
Son yıllardaki teknik gelişmeler nedeniyle kardiyovasküler hastalıkların tanısında bilgisayarlı tomografinin yeri gün geçtikçe artmaktadır. Ancak bu işlem sırasında kullanılan radyasyon dozu, buna bağlı oluşabilecek potansiyel sonuçlar konusunda tartışma yaratmaktadır. Elimizde henüz bilgisayarlı tomografide kullanılan radyasyon dozunun yol açabileceği istenmeyen etkiler konusunda net veriler bulunmamaktadır. Bu derlemede bilgisayarlı tomografi ve radyasyon riski ile ilgili literatürdeki veriler gözden geçirilmiştir. Bilgisayarlı tomografide kullanılan radyasyon dozunu azaltmak için alınabilecek önlemlerin başında testin doğru endikasyonla, uygun hastada yapılması gelmektedir. Bunun yanında son yıllarda geliştirilen radyasyon azaltıcı teknolojiler ve kişiye özgü çekim teknikleri sayesinde kullanılan radyasyon dozu belirgin ölçüde azaltılabilmektedir. Klinisyenlerin radyasyon riskinin azaltılması açısından kullanılması gereken teknikler konusunda bilgi sahibi olmaları ve çalıştıkları merkezdeki teknik olanakların farkında olmaları önem taşımaktadır.With the recent technological developments, computed tomography is becoming more important in the diagnosis of cardiovascular diseases. However, potential complications of the radiation dose used during the test have led debates. In the current situation, the data about undesirable effects of radiation dose used in cardiac computed tomography is not clear. In this paper, we reviewed the data about computed tomography and the risk of radiation. In order to reduce the risk of radiation due to computed tomography, the test should be performed with proper indication and in suitable patients. Besides, recently developed radiation dose reduction technologies and patient specific protocols have significantly reduced the radiation exposure. The clinicians should be well informed about the radiation reduction techniques and aware of the technical capabilities in their hospital.
- Published
- 2013
46. [Coronary calcification: what does calcium score mean?]
- Author
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Asife Sahinarslan
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Coronary artery calcification ,Cardiology ,medicine ,Humans ,Coronary Artery Disease ,Cardiology and Cardiovascular Medicine ,business ,Tunica Intima ,Vascular Calcification ,Calcium score - Published
- 2013
47. Inverse relationship between serum total bilirubin levels and severity of disease in patients with stable coronary artery disease
- Author
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Murat Turfan, Mustafa Duran, Çağrı Yayla, Fatih Poyraz, Bulent Boyaci, Yusuf Tavil, Hatice Pasaoglu, Mehmet Kadri Akboga, and Asife Sahinarslan
- Subjects
Male ,medicine.medical_specialty ,Bilirubin ,Coronary Artery Disease ,Disease ,Coronary Angiography ,Severity of Illness Index ,Coronary artery disease ,chemistry.chemical_compound ,Serum total bilirubin ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Odds Ratio ,Humans ,Medicine ,In patient ,Aged ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Logistic Models ,chemistry ,Multivariate Analysis ,Angiography ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Many studies have shown that bilirubin may protect against atherosclerosis. In the present study, we assess the association between serum total bilirubin levels and the severity of coronary artery disease (CAD) assessed by angiography and the Syntax score.Patients from our center, who visited the center for a coronary angiography, from January 2008 to January 2011, were eligible for this analysis. Serum bilirubin levels and other blood parameters in at least 12-h fasting states were determined. The patients were divided into tertiles according to their Syntax score.A total of 299 patients were registered for the study. The total bilirubin levels in the low Syntax score group were significantly higher than those of the other groups. After multiple logistic regression analysis, serum bilirubin levels (odds ratio=0.155, 95% confidence interval, 0.039-0.62, P=0.008) were identified as independent correlates of a high Syntax score.Serum bilirubin levels were independently and inversely associated with the severity of disease in patients with stable CAD. Serum total bilirubin level may be useful as a marker of the severity of CAD.
- Published
- 2013
48. Biventricular thrombus and associated myocardial infarction in a rheumatoid arthritis patient: a case report and literature review
- Author
-
Eser Açıkgöz, Asife Sahinarslan, Çağrı Yayla, and Sadık Kadri Açıkgöz
- Subjects
Adult ,medicine.medical_specialty ,Heart Ventricles ,Myocardial Infarction ,Arthritis ,Coronary Angiography ,Arthritis, Rheumatoid ,Rheumatology ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Thrombus ,business.industry ,Thrombosis ,General Medicine ,Left ventricular thrombus ,medicine.disease ,Surgery ,Venous thrombosis ,Treatment Outcome ,Embolism ,Echocardiography ,Rheumatoid arthritis ,Cardiology ,cardiovascular system ,Myocardial infarction complications ,Female ,Warfarin ,business ,Tomography, X-Ray Computed - Abstract
Autoimmune diseases including rheumatoid arthritis have an increased incidence of cardiovascular disease. Rheumatoid arthritis (RA) confers a prothrombotic state and is associated with venous thrombosis, but its association with arterial thrombosis and embolism is not clear. In present report, we introduce a unique case of a 42-year-old woman with RA, who was admitted to the emergency service with back pain and diagnosed as having large right and left ventricular thrombus and myocardial infarction, associated with embolization of the thrombus. We also review the literature about RA and arterial and intraventricular thrombosis.
- Published
- 2012
49. Reply to letter from Günebakmaz and Kaya
- Author
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Asife Sahinarslan
- Subjects
Male ,business.industry ,Vascular Endothelial Growth Factors ,Medicine ,Collateral Circulation ,Humans ,Female ,Angina, Stable ,Theology ,Cardiology and Cardiovascular Medicine ,business ,Erythropoietin - Published
- 2012
50. Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population
- Author
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Hasan Ata Bolayir, Sevda Menevse, Burak Sezenöz, Asife Sahinarslan, Akin Yilmaz, Azmi Eyiol, Çağrı Yayla, Atiye Seda Yar Saglam, Kaan Okyay, and Atiye Çengel
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Turkish population ,Multivariate analysis ,Locus (genetics) ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Genetics ,Internal Medicine ,medicine ,Genetic predisposition ,cardiovascular diseases ,Polymorphism ,Allele ,business.industry ,Significant difference ,Atherosclerosis ,medicine.disease ,030104 developmental biology ,Coronary vessel ,Cardiology ,Original Article ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Objectives: Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods: A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results: There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71 +/- 1.04, GG 0.88 +/- 1.07, AG 1.06 +/- 1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion: The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.
- Published
- 2016
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