1. Long-term viremia and fecal shedding in pups after modified-live canine parvovirus vaccination.
- Author
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Decaro N, Crescenzo G, Desario C, Cavalli A, Losurdo M, Colaianni ML, Ventrella G, Rizzi S, Aulicino S, Lucente MS, and Buonavoglia C
- Subjects
- Animals, Antibodies, Viral blood, DNA, Viral isolation & purification, Dogs, Feces virology, Female, Hemagglutination Inhibition Tests, Male, Parvoviridae Infections prevention & control, Parvovirus, Canine, Vaccination veterinary, Vaccines, Attenuated administration & dosage, Viral Load, Dog Diseases prevention & control, Parvoviridae Infections veterinary, Viral Vaccines administration & dosage, Viremia diagnosis, Virus Shedding
- Abstract
Canine parvovirus (CPV) modified live virus vaccines are able to infect vaccinated dogs replicating in the bloodstream and enteric mucosa. However, the exact duration and extent of CPV vaccine-induced viremia and fecal shedding are not known. With the aim to fill this gap, 26 dogs were administered two commercial vaccines containing a CPV-2 or CPV-2b strain and monitored for 28 days after vaccination. By using real-time PCR, vaccine-induced viremia and shedding were found to be long lasting for both vaccinal strains. Vaccinal CPV-2b shedding was detected for a shorter period than CPV-2 (12 against 19 mean days) but with greater viral loads, whereas viremia occurred for a longer period (22 against 19 mean days) and with higher titers for CPV-2b. Seroconversion appeared as early as 7 and 14 days post-vaccination for CPV-2b and CPV-2 vaccines, respectively. With no vaccine there was any diagnostic interference using in-clinic or hemagglutination test, since positive results were obtained only by fecal real-time PCR testing. The present study adds new insights into the CPV vaccine persistence in the organism and possible interference with diagnostic tests., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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