40 results on '"Batlles-Garrido J"'
Search Results
2. Prevalence and factors linked to atopic eczema in 10- and 11-year-old schoolchildren. Isaac 2 in Almeria, Spain
- Author
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Batlles Garrido, J., Torres-Borrego, J., Bonillo Perales, A., Rubí Ruiz, T., González Jiménez, Y., Momblán De Cabo, J., Aguirre Rodríguez, J., Jiménez Liria, R., Losilla Maldonado, A., and Daza Torres, M.
- Published
- 2010
- Full Text
- View/download PDF
3. Prevalence and factors linked to atopy in 10-and 11-year-old children in Almería, Spain
- Author
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Batllés-Garrido, J., Torres-Borrego, J., Rubí-Ruiz, T., Bonillo-Perales, A., González-Jiménez, Y., Momblán De Cabo, J., Aguirre-Rodríguez, J., Losillas-Maldonado, A., and Torres-Daza, M.
- Published
- 2010
- Full Text
- View/download PDF
4. Can environment or allergy explain international variation in prevalence of wheeze in childhood?
- Author
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Weinmayr, G., Jaensch, A., Ruelius, A. -K., Forastiere, F., Strachan, D. P., Weiland, S. K., Buchele, G., Dentler, C., Rzehak, P., Priftanji, A., Shkurti, A., Simenati, J., Grabocka, E., Shyti, K., Agolli, S., Gurakuqi, A., Stein, R. T., de Pereira, M. U., Jones, M. H., Pitrez, P. M., Cooper, P. J., Chico, M., Chen, Y. Z., Zhong, N. S., Lai, C. K. W., Wong, G. W. K., Riikjarv, M. -A., Annus, T., Annesi-Maesano, I., Gotua, M., Rukhadze, M., Abramidze, T., Kvachadze, I., Karsanidze, L., Kiladze, M., Dolidze, N., Leupold, W., Keil, U., von Mutius, E., Arthur, P., Addo-Yobo, E., Gratziou, C., Priftis, K., Papadopoulou, A., Katsardis, C., Tsanakas, J., Hatziagorou, E., Kirvassilis, F., Clausen, M., Shah, J. R., Mathur, R. S., Khubchandani, R. P., Mantri, S., Di Domenicantonio, R., De Sario, M., Sammarro, S., Pistelli, Riccardo, Serra, M. G., Corbo, Giuseppe Maria, Perucci, C. A., Svabe, V., Sebre, D., Casno, G., Novikova, I., Bagrade, L., Brunekreef, B., Schram, D., Doekes, G., Jansen-van Vliet, P. H. N., Janssen, N. A. H., Aarts, F. J. H., de Meer, G., Crane, J., Wickens, K., Barry, D., Nystad, W., Bolle, R., Lund, E., Batlles Garrido, J., Rubi Ruiz, T., Bonillo Perales, A., Gonzalez Jimenez, Y., Aguirre Rodriguez, J., Momblan deCabo, J., Losilla Maldonado, A., Daza Torres, M., Garcia-Marcos, L., Martinez Torres, A., Guillen Perez, J. J., Pinana Lopez, A., Castejon Robles, S., Garcia Hernandez, G., Martinez Gimeno, A., Moro Rodriguez, A. L., Luna Paredes, C., Gonzalez Gil, I., Morales Suarez-Varela, M. M., Llopis Gonzalez, A., Escribano Montaner, A., Tallon Guerola, M., Braback, L., Kjellman, M., Nilsson, L., Mai, X. -M., Sandin, A., Saraclar, Y., Kuyucu, S., Tuncer, A., Sackesen, C., Sumbuloglu, V., Geyik, P., Kocabas, C., Kaur, B., El-Sharif, N., Nemery, B., Barghuthy, F., Abu Huij, S., Qlebo, M., van Hage, M., Ait-Khaled, N., Anderson, H. R., Flohr, C., Williams, John Harford, Asher, I., Ellwood, P., Stewart, A., Mitchell, E., Pearce, N., Beasley, R., Bjorksten, B., Foliaki, S., Mallol, J., Montefort, S., Odhiambo, J., and Robertson, C.
- Subjects
International variation ,medicine.medical_specialty ,Allergy ,Epidemiology ,Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO ,Environment ,030204 cardiovascular system & hematology ,Global Health ,medicine.disease_cause ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Wheeze ,Hypersensitivity ,Prevalence ,Humans ,Medicine ,Environmental risk factors ,030212 general & internal medicine ,Risk factor ,Child ,Asthma ,business.industry ,Public health ,Aeroallergen ,medicine.disease ,medicine.symptom ,business ,Demography - Abstract
Asthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8-12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in prevalence of recent wheeze. Adjustment for single individual-level risk factors changed the centre-level variation from a reduction of up to 8.4% (and 8.5% for atopy) to an increase of up to 6.8%. Modelling the 11 most influential environmental factors among all children simultaneously, the centre-level variation changed little overall (2.4% increase). Modelling only factors that decreased the variance, the 6 most influential factors (synthetic and feather quilt, mother's smoking, heating stoves, dampness and foam pillows) in combination resulted in a 21% reduction in variance. Ecological (centre-level) risk factors generally explained higher proportions of the variation than did individual risk factors. Single environmental factors and aeroallergen sensitisation measured at the individual (child) level did not explain much of the between-centre variation in wheeze prevalence.
- Published
- 2018
5. Parents’ smoking habit and prevalence of atopic eczema in 6-7 and 13-14 year-old schoolchildren in Spain. ISAAC Phase III
- Author
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Morales Suárez-Varela, M., García-Marcos, L., Kogan, M.D., Llopis González, A., Martínez Gimeno, A., Aguinaga Ontoso, I., González Díaz, C., Arnedo Peña, A., Domínguez Aurrecoechea, B., Busquets Monge, R.M., Blanco Quirós, A., Batlles Garrido, J., Miner Canflanca, I., López-Silvarrey Várela, A., and Gimeno Clemente, N.
- Published
- 2008
- Full Text
- View/download PDF
6. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2
- Author
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Genuneit, J., Cantelmo, J. L., Weinmayr, G., Wong, G. W. K., Cooper, P. J., Riikjärv, M.-A., Gotua, M., Kabesch, M., von Mutius, E., Forastiere, F., Crane, J., Nystad, W., El-Sharif, N., Batlles-Garrido, J., García-Marcos, L., García-Hernández, G., Morales-Suarez-Varela, M., Nilsson, L., Bråbäck, L., Saraçlar, Y., Weiland, S. K., Cookson, W. O. C., Strachan, D., and Moffatt, M. F.
- Published
- 2009
- Full Text
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7. Geographic Variation in the Prevalence of Asthma Symptoms in Spanish Children and Adolescents. International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3, Spain
- Author
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Carvajal-Urueña, I., García-Marcos, L., Busquets-Monge, R., Morales Suárez-Varela, M., García de Andoin, N., Batlles-Garrido, J., Blanco-Quirós, A., López-Silvarrey, A., García-Hernández, G., Guillén-Grima, F., González-Díaz, C., and Bellido-Blasco, J.
- Published
- 2005
- Full Text
- View/download PDF
8. Variaciones geográficas en la prevalencia de síntomas de asma en los niños y adolescentes españoles. International Study of Asthma and Allergies in Childhood (ISAAC) fase III España
- Author
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Carvajal-Urueña, I., García-Marcos, L., Busquets-Monge, R., Morales Suárez-Varela, M., García de Andoin, N., Batlles-Garrido, J., Blanco-Quirós, A., López-Silvarrey, A., García-Hernández, G., Guillén-Grima, F., González-Díaz, C., and Bellido-Blasco, J.
- Published
- 2005
- Full Text
- View/download PDF
9. How the presence of rhinoconjunctivitis and the severity of asthma modify the relationship between obesity and asthma in children 6–7 years old
- Author
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Garcia-Marcos, L., Pena, A. Arnedo, Busquets-Monge, R., Suárez-Varela, M. Morales, García de Andoin, N., Batlles-Garrido, J., Blanco-Quirós, A., López-Silvarrey Varela, A., García-Hernández, G., Aguinaga-Ontoso, I., González-Díaz, C., and Garcia-Merino, A.
- Published
- 2008
10. Can environment or allergy explain international variation in prevalence of wheeze in childhood?
- Author
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Weinmayr, G., Jaensch, A., Ruelius, A. -K., Forastiere, F., Strachan, D. P., Weiland, S. K., Buchele, G., Dentler, C., Rzehak, P., Priftanji, A., Shkurti, A., Simenati, J., Grabocka, E., Shyti, K., Agolli, S., Gurakuqi, A., Stein, R. T., de Pereira, M. U., Jones, M. H., Pitrez, P. M., Cooper, P. J., Chico, M., Chen, Y. Z., Zhong, N. S., Lai, C. K. W., Wong, G. W. K., Riikjarv, M. -A., Annus, T., Annesi-Maesano, I., Gotua, M., Rukhadze, M., Abramidze, T., Kvachadze, I., Karsanidze, L., Kiladze, M., Dolidze, N., Leupold, W., Keil, U., von Mutius, E., Arthur, P., Addo-Yobo, E., Gratziou, C., Priftis, K., Papadopoulou, A., Katsardis, C., Tsanakas, J., Hatziagorou, E., Kirvassilis, F., Clausen, M., Shah, J. R., Mathur, R. S., Khubchandani, R. P., Mantri, S., Di Domenicantonio, R., De Sario, M., Sammarro, S., Pistelli, R., Serra, M. G., Corbo, G., Perucci, C. A., Svabe, V., Sebre, D., Casno, G., Novikova, I., Bagrade, L., Brunekreef, B., Schram, D., Doekes, G., Jansen-van Vliet, P. H. N., Janssen, N. A. H., Aarts, F. J. H., de Meer, G., Crane, J., Wickens, K., Barry, D., Nystad, W., Bolle, R., Lund, E., Batlles Garrido, J., Rubi Ruiz, T., Bonillo Perales, A., Gonzalez Jimenez, Y., Aguirre Rodriguez, J., Momblan deCabo, J., Losilla Maldonado, A., Daza Torres, M., Garcia-Marcos, L., Martinez Torres, A., Guillen Perez, J. J., Pinana Lopez, A., Castejon Robles, S., Garcia Hernandez, G., Martinez Gimeno, A., Moro Rodriguez, A. L., Luna Paredes, C., Gonzalez Gil, I., Morales Suarez-Varela, M. M., Llopis Gonzalez, A., Escribano Montaner, A., Tallon Guerola, M., Braback, L., Kjellman, M., Nilsson, L., Mai, X. -M., Sandin, A., Saraclar, Y., Kuyucu, S., Tuncer, A., Sackesen, C., Sumbuloglu, V., Geyik, P., Kocabas, C., Kaur, B., El-Sharif, N., Nemery, B., Barghuthy, F., Abu Huij, S., Qlebo, M., van Hage, M., Ait-Khaled, N., Anderson, H. R., Flohr, C., Williams, H., Asher, I., Ellwood, P., Stewart, A., Mitchell, E., Pearce, N., Beasley, R., Bjorksten, B., Foliaki, S., Mallol, J., Montefort, S., Odhiambo, J., Robertson, C., Pistelli R. (ORCID:0000-0003-3776-2482), Corbo G. (ORCID:0000-0002-8104-4659), Williams H., Weinmayr, G., Jaensch, A., Ruelius, A. -K., Forastiere, F., Strachan, D. P., Weiland, S. K., Buchele, G., Dentler, C., Rzehak, P., Priftanji, A., Shkurti, A., Simenati, J., Grabocka, E., Shyti, K., Agolli, S., Gurakuqi, A., Stein, R. T., de Pereira, M. U., Jones, M. H., Pitrez, P. M., Cooper, P. J., Chico, M., Chen, Y. Z., Zhong, N. S., Lai, C. K. W., Wong, G. W. K., Riikjarv, M. -A., Annus, T., Annesi-Maesano, I., Gotua, M., Rukhadze, M., Abramidze, T., Kvachadze, I., Karsanidze, L., Kiladze, M., Dolidze, N., Leupold, W., Keil, U., von Mutius, E., Arthur, P., Addo-Yobo, E., Gratziou, C., Priftis, K., Papadopoulou, A., Katsardis, C., Tsanakas, J., Hatziagorou, E., Kirvassilis, F., Clausen, M., Shah, J. R., Mathur, R. S., Khubchandani, R. P., Mantri, S., Di Domenicantonio, R., De Sario, M., Sammarro, S., Pistelli, R., Serra, M. G., Corbo, G., Perucci, C. A., Svabe, V., Sebre, D., Casno, G., Novikova, I., Bagrade, L., Brunekreef, B., Schram, D., Doekes, G., Jansen-van Vliet, P. H. N., Janssen, N. A. H., Aarts, F. J. H., de Meer, G., Crane, J., Wickens, K., Barry, D., Nystad, W., Bolle, R., Lund, E., Batlles Garrido, J., Rubi Ruiz, T., Bonillo Perales, A., Gonzalez Jimenez, Y., Aguirre Rodriguez, J., Momblan deCabo, J., Losilla Maldonado, A., Daza Torres, M., Garcia-Marcos, L., Martinez Torres, A., Guillen Perez, J. J., Pinana Lopez, A., Castejon Robles, S., Garcia Hernandez, G., Martinez Gimeno, A., Moro Rodriguez, A. L., Luna Paredes, C., Gonzalez Gil, I., Morales Suarez-Varela, M. M., Llopis Gonzalez, A., Escribano Montaner, A., Tallon Guerola, M., Braback, L., Kjellman, M., Nilsson, L., Mai, X. -M., Sandin, A., Saraclar, Y., Kuyucu, S., Tuncer, A., Sackesen, C., Sumbuloglu, V., Geyik, P., Kocabas, C., Kaur, B., El-Sharif, N., Nemery, B., Barghuthy, F., Abu Huij, S., Qlebo, M., van Hage, M., Ait-Khaled, N., Anderson, H. R., Flohr, C., Williams, H., Asher, I., Ellwood, P., Stewart, A., Mitchell, E., Pearce, N., Beasley, R., Bjorksten, B., Foliaki, S., Mallol, J., Montefort, S., Odhiambo, J., Robertson, C., Pistelli R. (ORCID:0000-0003-3776-2482), Corbo G. (ORCID:0000-0002-8104-4659), and Williams H.
- Abstract
Asthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8–12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in prevalence of recent wheeze. Adjustment for single individual-level risk factors changed the centre-level variation from a reduction of up to 8.4% (and 8.5% for atopy) to an increase of up to 6.8%. Modelling the 11 most influential environmental factors among all children simultaneously, the centre-level variation changed little overall (2.4% increase). Modelling only factors that decreased the variance, the 6 most influential factors (synthetic and feather quilt, mother’s smoking, heating stoves, dampness and foam pillows) in combination resulted in a 21% reduction in variance. Ecological (centre-level) risk factors generally explained higher proportions of the variation than did individual risk factors. Single environmental factors and aeroallergen sensitisation measured at the individual (child) level did not explain much of the between-centre variation in wheeze prevalence.
- Published
- 2019
11. International Study of Asthma and Allergies in Childhood (ISAAC) fase II: metodología y resultados de participación en España
- Author
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García-Marcos Álvarez, L., Martínez Torres, A., Batlles Garrido, J., Morales Suárez-Varela, M.<ce:sup loc='post">a</ce:sup>, García Hernández, G., and Escribano Montaner, A.
- Published
- 2001
- Full Text
- View/download PDF
12. Antecedentes perinatales y hospitalización por bronquiolitis. Comparación con el Impact-RSV Study Group
- Author
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Bonillo Perales, A., Díez-Delgado Rubio, J., Ortega Montes, A., Infante Márquez, P., Jiménez Liria, M.R., Batlles Garrido, J., and López Muñoz, J.
- Published
- 2000
- Full Text
- View/download PDF
13. The Impact of Atmospheric Pollutants on the Prevalence of Atopic Eczema in 6-7-Year-Old Schoolchildren in Spain; ISAAC Phase III
- Author
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Morales-Suárez-Varela, M., Gallardo-Juan, A., García-Marcos, L., Gimeno-Clemente, N., López-Silvarrey-Varela, Á, Miner-Canflanca, I., Batlles-Garrido, J., Blanco-Quiros, A., Busquets-Monge, R. M., Domínguez-Aurrecoechea, B., Arnedo-Pena, A., González-Díaz, C., Aguinaga-Ontoso, I., Martínez-Gimeno, A., and Agustín Llopis González
- Subjects
Atopic Eczema ,Atmospheric Pollutants ,lcsh:R ,lcsh:Medicine ,Phase III ISAAC Study - Abstract
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life with a high morbidity rate and severe economic burden. The objective of the present work was to analyse specific atmospheric pollutants (O3, NO, PM10 and SO2) affecting the prevalence of diagnosed AE and its symptoms among 6-7-year-old schoolchildren. The participants included 21311 schoolchildren aged 6-7 years from 8 Spanish regions, whose parents completed the ISAAC Phase III questionnaire to ascertain AE diagnosis and symptoms. The mean levels (µg/m3) of O3, NO, PM10 (particles 10 micrometers or less in diameter) and SO2 were determined in each geographical area participating in this study. According to these mean levels, three levels of exposure to each pollutant were considered: level 1 (percentiles 0-25); level 2 (percentiles 26-74); level 3 (percentiles 75-100). Exposure to O3 was associated with increased prevalence of rashes (exposure level 2, Odds Ratio (OR): 1.22, 95% Confidence Interval (95%CI): 1.02-1.45; level 3 OR: 1.33, 95%CI:1.10-1.61) and diagnosed AE (level 2, OR: 1.27, 95%CI: 1.17-1.39; level 3 OR: 1.27, 95%CI:1.15-1.41). An association was found between the level of NO and a drop in the prevalence of diagnosed AE (exposure level 2, OR: 0.88, 95%CI: 0.81-0.95; level 3 OR: 0.85, 95%CI:0.74-0.97). There was also an association between the highest exposure level to PM10 and a reduced prevalence of rashes (level 3 OR: 0.42, 95%CI: 0.22-0.81) and diagnosed AE (level 3OR: 0.53, 95%CI: 0.38-0.75). Future studies into exposure to O3 and its relationship with allergic diseases may be conducted in order to prevent this association.
- Published
- 2013
14. C-15. Epidemia de tuberculosis en una guardería
- Author
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Seijas Vázquez, L., Azor Martínez, E., Fernández Campos, M.A., Fornovi Vives, J.J., Batlles Garrido, J., and Rubí Ruiz, M.T.
- Published
- 2010
15. C-15. Epidemia de tuberculosis en una guardería
- Author
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Seijas Vázquez,L., Azor Martínez,E., Fernández Campos,M.A., Fornovi Vives,J.J., Batlles Garrido,J., and Rubí Ruiz,M.T.
- Published
- 2010
16. [Perinatal history and hospitalization for bronchiolitis. A comparison with the impact-RSV Study Group]
- Author
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Bonillo Perales A, DíezDelgado Rubio J, Ortega Montes A, Infante Márquez P, Jiménez Liria M, Batlles Garrido J, and López Muñoz J
- Subjects
Hospitalization ,Risk Factors ,Incidence ,Respiratory Syncytial Virus, Human ,Infant, Newborn ,Bronchiolitis, Viral ,Humans ,Infant ,Infant, Premature, Diseases ,Respiratory Syncytial Virus Infections ,Retrospective Studies - Abstract
To describe the rate of hospitalization for bronchiolitis among newborn infants in our environment, to evaluate the influence of prematurity and other perinatal conditions on hospitalization for bronchiolitis, and to compare our data with those of the Impact-RSV Study Group.Descriptive studying based on analysis of the perinatal data of all neonates and patients hospitalized for bronchiolitis during a 3-year period.Among 12,895 newborn infants, 455 (3.52 %) required hospitalization for bronchiolitis. The hospitalization rate for bronchiolitis was 3.18 % among term infants, 8.6 % among preterm infants, 9.8 % among infants with congenital heart disease and 21.1 % among preterm infants who required mechanical ventilation during the neonatal period. Intensive care unit admission was associated with postnatal age under 6 weeks (OR: 1.68; 95 % CI: 1.04-8.19; p 5 0.04) and prematurity (OR: 2,67; 95 % CI: 1.01-7.56; p 5 0.006). The hospitalization rate for bronchiolitis was 40 % lower in our neonatal population than in that of the Impact-RSV Study Group. When infants with bronchopulmonary dysplasia, congenital heart disease and mechanical ventilation during the neonatal period were excluded, the hospitalization rate for respiratory syncytial virus (RSV) was not significantly different between infants born atweeks' gestation and those born at32 weeks' gestation and those born at 32-35 weeks' gestation (3.4% vs 4.3%; p0.10).Neonatal mechanical ventilation, bronchopulmonary dysplasia and congenital heart disease are more closely associated with hospitalization for RSV(1) bronchiolitis and mean length of stay than with gestational age.
- Published
- 2001
17. Prevalence and factors linked to allergic rhinitis in 10 and 11-year-old children in Almería. Isaac Phase II, Spain
- Author
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Batlles-Garrido, J., primary, Torres-Borrego, J., additional, Rubí-Ruiz, T., additional, Bonillo-Perales, A., additional, González-Jiménez, Y., additional, Momblán-De Cabo, J., additional, Aguirre-Rodríguez, J., additional, Losillas-Maldonado, A., additional, and Torres-Daza, M., additional
- Published
- 2010
- Full Text
- View/download PDF
18. How the presence of rhinoconjunctivitis and the severity of asthma modify the relationship between obesity and asthma in children 67 years old
- Author
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Garcia-Marcos, L., primary, Arnedo Pena, A., additional, Busquets-Monge, R., additional, Morales Surez-Varela, M., additional, Garca de Andoin, N., additional, Batlles-Garrido, J., additional, Blanco-Quirs, A., additional, Lpez-Silvarrey Varela, A., additional, Garca-Hernndez, G., additional, Aguinaga-Ontoso, I., additional, Gonzlez-Daz, C., additional, and Garcia-Merino, A., additional
- Published
- 2008
- Full Text
- View/download PDF
19. Tendencia temporal y variaciones geográficas de la prevalencia de síntomas de rinitis alérgica en escolares de 6-7 años de ocho áreas españolas, según el ISAAC
- Author
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Arnedo-Pena, A., primary, García-Marcos, L., additional, García Hernández, G., additional, Aguinagua Ontoso, I., additional, González Díaz, C., additional, Morales Suárez-Varela, M., additional, Domínguez Aurrecoechea, B., additional, Busquets Monge, R., additional, Blanco Quiros, A., additional, Batlles Garrido, J., additional, Miner Kanflanka, I., additional, and López-Silvarrey Varela, A., additional
- Published
- 2005
- Full Text
- View/download PDF
20. BCG Immunization at Birth and Atopic Diseases in a Homogeneous Population of Spanish Schoolchildren
- Author
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García-Marcos, L., primary, Morales Suárez-Varela, M., additional, Miner Canflanca, I., additional, Batlles Garrido, J., additional, Blanco Quirós, A., additional, López-Silvarrey Varela, A., additional, García Hernández, G., additional, Guillén-Grima, F., additional, González Díaz, C., additional, Huerta González, I., additional, Arnedo Pena, A., additional, and Busquets Monge, R., additional
- Published
- 2005
- Full Text
- View/download PDF
21. Is acetaminophen use associated with atopic eczema and other allergic diseases in adolescents?
- Author
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Mm, Suárez-Varela, García-Marcos L, Jf, Fernández-Espinar, Bercedo-Sanz A, Ines Aguinaga-Ontoso, González-Díaz C, Carvajal-Urueña I, Rm, Busquet-Monge, Arnedo-Pena A, García de Andoin N, Batlles-Garrido J, Blanco-Quirós A, López-Silvarrey Varela A, García-Hernández G, Gimeno-Clemente N, Rubio-López N, and Llopis-González A
- Subjects
Male ,Atopic Eczema ,Adolescent ,lcsh:R ,lcsh:Medicine ,Analgesics, Non-Narcotic ,Adolescents ,Asthma ,Dermatitis, Atopic ,Cross-Sectional Studies ,Surveys and Questionnaires ,Hypersensitivity ,Prevalence ,Humans ,Female ,Acetaminophen ,Rhinitis - Abstract
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life. Previous studies have suggested several socio-demographic and environmental factors related to the prevalence of AE and other allergic diseases, including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms. We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively. We conclude that acetaminophen use in childhood may be an important factor associated with development and/or maintenance of AE and other allergic diseases.
22. Diet and prevalence of atopic eczema in 6 to 7-year-old schoolchildren in Spain: ISAAC phase III
- Author
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Mm, Suárez-Varela, Lg, Alvarez, Md, Kogan, Jc, Ferreira, Martínez Gimeno A, Ines Aguinaga-Ontoso, González Díaz C, Arnedo Pena A, Domínguez Aurrecoechea B, Rm, Busquets Monge, Blanco Quiros A, Batlles Garrido J, García de Andoain N, Al, Varela, García Merino A, Gimeno Clemente N, and Llopis González A
- Subjects
Male ,Cross-Sectional Studies ,Spain ,Prevalence ,Humans ,Female ,Obesity ,Child ,Diet, Mediterranean ,Dermatitis, Atopic ,Diet - Abstract
The prevalence of atopic dermatitis (AD), a chronic skin disease, has increased substantially in recent decades, and different factors have been implicated in its etiology. Although dietary habits are being investigated, few conclusive findings have been reported. Nevertheless, increased consumption of polyunsaturated fatty acids (PUFA) and a diet poor in antioxidants have been related to AD.The objectives of this study were to investigate the association between AD, the intake of different foods, and the effect of a Mediterranean diet among Spanish schoolchildren aged 6 to 7.We performed a cross-sectional study with 20 106 schoolchildren aged 6-7 years from 10 different areas of Spain. The participation rate was 76.50%. The prevalence of AD was assessed using the International Study of Asthma and Allergies in Childhood questionnaire and the criteria of the Spanish Academy of Dermatology. To calculate the Mediterranean diet score, we classified food into 2 groups: Mediterranean food, including fruit, seafood, vegetables, pulses, cereals, pasta, rice, and potatoes; and non-Mediterranean food, including meat, milk, and fast food.Milk was negatively associated with AD. Butter and nuts also were negatively associated, although statistical significance was only reached when these foods were consumed 3 or more times a week.We found no association between the Mediterranean diet score and AD and a positive association between AD and obesity.
23. Atopic dermatitis and indoor use of energy sources in cooking and heating appliances
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Vicedo-Cabrera Ana M, García-Marcos Luís, Llopis-González Agustín, López-Silvarrey-Varela Ángel, Miner-Canflanca Izaskun, Batlles-Garrido José, Blanco-Quiros Alfredo, Busquets-Monge Rosa María, Díaz-Vazquez Carlos, González-Díaz Carlos, Martínez-Gimeno Antonio, Guillén-Grima Francisco, Arnedo-Pena Alberto, and Morales-Suárez-Varela María
- Subjects
Atopic dermatitis ,Electricity ,Gas ,Biomass ,Indoor ,Children ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Atopic dermatitis (AD) prevalence has considerably increased worldwide in recent years. Studying indoor environments is particularly relevant, especially in industrialised countries where many people spend 80% of their time at home, particularly children. This study is aimed to identify the potential association between AD and the energy source (biomass, gas and electricity) used for cooking and domestic heating in a Spanish schoolchildren population. Methods As part of the ISAAC (International Study of Asthma and Allergies in Childhood) phase III study, a cross-sectional population-based survey was conducted with 21,355 6-to-7-year-old children from 8 Spanish ISAAC centres. AD prevalence, environmental risk factors and the use of domestic heating/cooking devices were assessed using the validated ISAAC questionnaire. Crude and adjusted odds ratios (cOR, aOR) and 95% confidence intervals (CIs) were obtained. A logistic regression analysis was performed (Chi-square test, p-value Results It was found that the use of biomass systems gave the highest cORs, but only electric cookers showed a significant cOR of 1.14 (95% CI: 1.01-1.27). When the geographical area and the mother’s educational level were included in the logistic model, the obtained aOR values differed moderately from the initial cORs. Electric heating was the only type which obtained a significant aOR (1.13; 95% CI: 1.00-1.27). Finally, the model with all selected confounding variables (sex, BMI, number of siblings, mother’s educational level, smoking habits of parents, truck traffic and geographical area), showed aOR values which were very similar to those obtained in the previous adjusted logistic analysis. None of the results was statistically significant, but the use of electric heating showed an aOR close to significance (1.14; 95% CI: 0.99-1.31). Conclusion In our study population, no statistically significant associations were found between the type of indoor energy sources used and the presence of AD.
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- 2012
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24. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II
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Weinmayr, G., Forastiere, F., Weiland, S. K., Rzehak, P., Abramidze, T., Annesi-Maesano, Isabella, Björkstén, B., Brunekreef, B., Büchele, G., Cookson, W. O. C., Von Mutius, E., Pistelli, R., Strachan, D. P., Renseigné, Non, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), G Büchele, Garcia-Hernandez G, SK Weiland, Groupe d'étude ISAAC Phase II . Collaborateurs (149) Bjorksten B, B Brunekreef, W Cookson, Strachan D, E von Mutius, Kleiner A, G Nagel, P Rzehak, G Weinmayr, Priftanji A, A Shkurti, Simenati J, Grabocka E, Shyti K, S Agolli, Gurakuqi A, RT Stein, de Pereira MU, MH Jones, B Bjorksten, PM Pitrez, Cooper PJ, M Chico, Zhong NS, C Lei, Wong G, MA Riikjärv, T Annus, Annesi-Maesano I, M Gotua, YZ Chen, M Rukhadze, T Abramidze, Kvachadze I, L Karsanidze, M Kiladze, N Dolidze, W Leupold, U Keil, von Mutius E, Arthur P, Wang H, E-Addo Yobo, C Gratziou, C Priftis, Papadopoulou A, C Katsardis, Tsanakas J, E Hatziagorou, Kirvassilis F, M Clausen, JR Shah, W Nystad, RS Mathur, RP Khubchandani, S Mantri, Forastière F, Di Domenicantonio R, De Sario M, S Sammarro, R Pis, Y Saraclar, L Bråbäck, Batlles-Garrido J, and Çocuk Sağlığı ve Hastalıkları
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Male ,Pediatrics ,Time Factors ,MESH: Asthma ,MESH: Respiratory Sounds ,Respiratory System ,Breastfeeding ,MESH: Logistic Models ,MESH: Respiratory Function Tests ,Atopy ,MESH: Conjunctivitis ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Surveys and Questionnaires ,MESH: Child ,030212 general & internal medicine ,Child ,MESH: Rhinitis ,Respiratory Function Tests ,3. Good health ,Breast Feeding ,MESH: Breast Feeding ,Female ,Bronchial Hyperreactivity ,medicine.symptom ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,MESH: Socioeconomic Factors ,MESH: Allergens ,MESH: Hypersensitivity ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,MESH: Skin Tests ,Wheeze ,medicine ,Humans ,MESH: Prevalence ,Respiratory Sounds ,Retrospective Studies ,Asthma ,MESH: Humans ,MESH: Rhinitis, Allergic, Perennial ,business.industry ,MESH: Questionnaires ,MESH: Time Factors ,MESH: Bronchial Hyperreactivity ,MESH: Rhinitis, Allergic, Seasonal ,MESH: Retrospective Studies ,Odds ratio ,medicine.disease ,Confidence interval ,MESH: Male ,Logistic Models ,Socioeconomic Factors ,030228 respiratory system ,El Niño ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Breast feeding ,MESH: Seasons ,MESH: Female ,MESH: Models, Statistical - Abstract
International audience; The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).
- Published
- 2009
25. Cost-effectiveness of omalizumab for the treatment of severe pediatric allergic asthma-Results of a real-life study in Spain.
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Nieto-Cid M, Garriga-Baraut T, Plaza-Martín AM, Tortajada-Girbés M, Torres-Borrego J, Lozano-Blasco J, Moreno-Galarraga L, Del Mar Folqué-Giménez M, Bosque-García M, Gaboli M, López-Neyra A, Rivas-Juesas C, Caballero-Rabasco MA, Freixa-Benavente A, Valdesoiro-Navarrete L, de Mir-Messa I, Ballester-Asensio E, Penín-Antón M, Romero-García R, Navarro-Morón J, Valenzuela-Soria A, Sánchez-Mateos M, Batlles-Garrido J, Sanz-Santiago V, de Atauri ÁG, Andrés-Martín A, Campos-Alonso E, Gómez-Pastrana D, Vázquez-Rodríguez E, Martínez-Pardo L, Del Río-Camacho G, Mazón-Ramos Á, and Nieto-García A
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- Humans, Child, Omalizumab therapeutic use, Cost-Benefit Analysis, Spain, Retrospective Studies, Treatment Outcome, Quality of Life, Anti-Asthmatic Agents therapeutic use, Asthma therapy
- Abstract
Background: Severe pediatric allergic asthma (SPAA) induces a huge economic burden in terms of direct, indirect, and intangible costs. The use of omalizumab for the treatment of these patients has produced a significant improvement in several clinical outcomes, but at the same time, the cost for the management of the disease has also increased. The aim of this report was to evaluate whether the use of omalizumab is cost-effective., Methods: A sample of 426 children with SPAA from the ANCHORS (Asthma iN CHildren: Omalizumab in Real-life in Spain) study was used to calculate the incremental cost-effectiveness ratio (ICER) for the avoidance of moderate-to-severe exacerbations (MSE) and also for the improvement in childhood Asthma Control Test (c-ACT) or the Asthma Control Questionnaire (ACQ5). We retrospectively collected data on health encounters and drug consumption before and up to 6 years after the beginning of the treatment with omalizumab., Results: The ICER per avoided MSE was €2107 after 1 year, and it consistently decreased to €656 in those followed up to 6 years. Similarly, the ICER for the minimally important difference in control tests showed a decrease from €2059 to €380 per each 0.5 points of improvement in ACQ5 and from €3141 to €2322 per each 3 points improvement in c-ACT, at years 1 and 6, respectively., Conclusion: The use of OMZ is a cost-effective option for most children with uncontrolled SPAA, especially those who have frequent exacerbations; the costs are progressively reduced in successive years of treatment., (© 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
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- 2023
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26. Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma.
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Nieto García A, Garriga-Baraut T, Plaza Martín AM, Nieto Cid M, Torres Borrego J, Folqué Giménez MDM, Lozano Blasco J, Bosque García M, Moreno-Galarraga L, Tortajada-Girbés M, Rivas Juesas C, Penín Antón M, Caballero-Rabasco MA, Gaboli M, López Neyra A, Navarro Morón J, Freixa Benavente A, Valdesoiro Navarrete L, Ballester Asensio E, Sanz Santiago V, Romero García R, Gimeno Díaz de Atauri Á, Valenzuela Soria A, Sánchez Mateos M, Batlles Garrido J, Andrés Martín A, Campos Alonso E, Aragón Fernández C, Vázquez Rodríguez E, Martínez Pardo L, Del-Río Camacho G, and Mazón Ramos Á
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- Anti-Asthmatic Agents adverse effects, Antibodies, Monoclonal, Humanized adverse effects, Child, Humans, Omalizumab adverse effects, Retrospective Studies, Treatment Outcome, Anti-Asthmatic Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Asthma drug therapy, Omalizumab therapeutic use
- Abstract
Background: Various studies have assessed omalizumab outcomes in the clinical practice setting but follow-up and/or number of patients included were limited. We aim to describe the long-term outcomes of pediatric patients with severe persistent allergic asthma receiving omalizumab in the largest real-life cohort reported to date., Methods: ANCHORS was a multicenter, observational, retrospective cohort study conducted in 25 Pediatric Allergy and Pulmonology units in Spain. We collected data of patients < 18 years and initiating omalizumab between 2006 and 2018, from the year prior to omalizumab initiation to discontinuation or last available follow-up. The primary outcome was the evolution of the annual number of moderate-to-severe exacerbations compared with the baseline period., Results: Of the 484 patients included, 101 (20.9%) reached 6 years of treatment. The mean ± standard deviation number of exacerbations decreased during the first year of treatment (7.9 ± 6.6 to 1.1 ± 2.0, P < .001) and remained likewise for up to 6 years. The other clinical parameters assessed also improved significantly during the first year and stabilized or continued to improve thereafter. The percentage of patients experiencing adverse events was consistently low, and the main reason for discontinuation was good disease evolution., Conclusion: In this large, long-term, observational study, moderate-to-severe exacerbations decreased significantly from the first year of treatment with omalizumab. The beneficial effect was maintained in the long term, along with a good safety profile. Our results position omalizumab as an effective long-term treatment in pediatric patients with severe persistent allergic asthma., (© 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)
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- 2021
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27. Prevalence of asthma symptoms in schoolchildren, and climate in west European countries: an ecologic study.
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Arnedo-Pena A, García-Marcos L, Bercedo-Sanz A, Aguinaga-Ontoso I, González-Díaz C, García-Merino A, Busquets-Monge R, Suárez-Varela MM, Batlles-Garrido J, Blanco-Quirós AA, López-Silvarrey A, García-Hernández G, and Fuertes J
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- Adolescent, Child, Europe epidemiology, Female, Humans, Male, Prevalence, Risk Factors, Asthma epidemiology, Climate, Environment, Students statistics & numerical data, Weather
- Abstract
The aim of the present study was to estimate the associations between the prevalence of asthma symptoms in schoolchildren and meteorological variables in west European countries that participated in the International Study of Asthma and Allergies in Children (ISAAC), Phase III 1997-2003. An ecologic study was carried out. The prevalence of asthma was obtained from this study from 48 centers in 14 countries, and meteorological variables from those stations closest to ISAAC centers, together with other socioeconomic and health care variables. Multilevel mixed-effects linear regression models were used. For schoolchildren aged 6-7 years, the prevalence rate of asthma decreased with an increase in mean annual sunshine hours, showed a positive association with rainy weather, and warm temperature, and a negative one with relative humidity and physician density (PD). Current wheeze prevalence was stronger in autumn/winter seasons and decreased with increasing PD. Severe current wheeze decreased with PD. For schoolchildren aged 13-14 years, the prevalence rates of asthma and current wheeze increased with rainy weather, and these rates decreased with increased PD. Current wheeze, as measured by a video questionnaire, was inversely associated with sunny weather, and nurse density. Severe current wheeze prevalence was stronger during autumn/winter seasons, decreased with PD, and indoor chlorinated public swimming pool density, and increased with rainy weather. Meteorological factors, including sunny and rainy weather, and PD may have some effect on the prevalence rates of asthma symptoms in children from west European countries.
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- 2013
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28. The impact of atmospheric pollutants on the prevalence of atopic eczema in 6-7-year-old schoolchildren in Spain; ISAAC Phase III.
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Suárez-Varela MM, Gallardo-Juan A, García-Marcos L, Gimeno-Clemente N, Silvarrey-Varela AL, Miner-Canflanca I, Batlles-Garrido J, Blanco-Quiros A, Busquets-Monge RM, Domínguez-Aurrecoechea B, Arnedo-Pena A, González-Díaz C, Aguinaga-Ontoso I, Martínez-Gimeno A, and Llopis-González A
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- Child, Dermatitis, Atopic chemically induced, Female, Humans, Logistic Models, Male, Prevalence, Spain epidemiology, Surveys and Questionnaires, Air Pollutants adverse effects, Dermatitis, Atopic epidemiology
- Abstract
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life with a high morbidity rate and severe economic burden. The objective of the present work was to analyse specific atmospheric pollutants (O3, NO, PM10 and SO2) affecting the prevalence of diagnosed AE and its symptoms among 6-7-year-old schoolchildren.The participants included 21311 schoolchildren aged 6-7 years from 8 Spanish regions, whose parents completed the ISAAC Phase III questionnaire to ascertain AE diagnosis and symptoms. The mean levels (µg/m3) of O3, NO, PM10 (particles 10 micrometers or less in diameter) and SO2 were determined in each geographical area. Participating in this study.According to these mean levels, three levels of exposure to each pollutant were considered: level 1 (percentiles 0-25); level 2 (percentiles 26-74); level 3 (percentiles 75-100). Exposure to O3 was associated with increased prevalence of rashes (exposure level 2, Odds Ratio (OR): 1.22, 95% Confidence Interval (95%CI): 1.02-1.45; level 3 OR: 1.33, 95%CI: 1.10-1.61) and diagnosed AE (level 2, OR: 1.27, 95%CI: 1.17-1.39; level 3 OR: 1.27, 95%CI: 1.15-1.41). An association was found between the level of NO and a drop in the prevalence of diagnosed AE (exposure level 2, OR: 0.88, 95%CI: 0.81-0.95; level 3 OR: 0.85, 95%CI: 0.74-0.97). There was also an association between the highest exposure level to PM10 and a reduced prevalence of rashes (level 3 OR: 0.42, 95%CI: 0.22-0.81) and diagnosed AE (level 3 OR: 0.53, 95%CI: 0.38-0.75). Future studies into exposure to O3 and its relationship with allergic diseases may be conducted in order to prevent this association.
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- 2013
29. Is acetaminophen use associated with atopic eczema and other allergic diseases in adolescents?
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Suárez-Varela MM, García-Marcos L, Fernández-Espinar JF, Bercedo-Sanz A, Aguinaga-Ontoso I, González-Díaz C, Carvajal-Urueña I, Busquet-Monge RM, Arnedo-Pena A, García de Andoin N, Batlles-Garrido J, Blanco-Quirós A, López-Silvarrey Varela A, García-Hernández G, Gimeno-Clemente N, Rubio-López N, and Llopis-González A
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- Adolescent, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Surveys and Questionnaires, Acetaminophen therapeutic use, Analgesics, Non-Narcotic therapeutic use, Dermatitis, Atopic epidemiology, Hypersensitivity epidemiology
- Abstract
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life. Previous studies have suggested several socio-demographic and environmental factors related to the prevalence of AE and other allergic diseases, including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms.We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively.We conclude that acetaminophen use in childhood may be an important factor associated with development and/or maintenance of AE and other allergic diseases.
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- 2013
30. Sunny hours and variations in the prevalence of asthma in schoolchildren according to the International Study of Asthma and Allergies (ISAAC) Phase III in Spain.
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Arnedo-Pena A, García-Marcos L, Fernández-Espinar JF, Bercedo-Sanz A, Aguinaga-Ontoso I, González-Díaz C, Carvajal-Urueña I, Busquet-Monge R, Suárez-Varela MM, de Andoin NG, Batlles-Garrido J, Blanco-Quirós A, Varela AL, and García-Hernández G
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- Adolescent, Child, Female, Global Health, Humans, Humidity, Male, Prevalence, Risk Factors, Spain epidemiology, Time Factors, Vitamin D metabolism, Asthma epidemiology, Climate, Rhinitis, Allergic, Seasonal epidemiology, Sunlight
- Abstract
The objective of this study was to estimate the relationship between the prevalence of asthma in schoolchildren aged 6-7 years and 13-14 years and the mean annual sunny hours (MASH) in Spain, and to explore predictive models for asthma prevalence. The prevalence of asthma was obtained from the International Study of Asthma and Allergies (ISAAC) Phase III 2002-2003, and climate and socio-economic variables from official sources. Nine centres were studied and a further four centres, two of which are in ISAAC, to test the predictive models. Logistic regression was used to estimate adjusted prevalence rates of asthma for each centre, and multiple regression models to study the effects of MASH and other meteorological and socio-economic variables. The adjusted prevalence rate of asthma decreased 0.6% [95% confidence interval (CI) 0.4-0.8%] for the 6-7 years group and 1.1% (95% CI 0.8-1.3%) for the 13-14 years group with an increase in the MASH of 100 h. Relative humidity was negatively associated with asthma in the older age group, and gross province product per capita (GPP) was positively associated with asthma in the younger age group. The predictive models, which included MASH, gender, relative humidity, and GPP, anticipated prevalence rates of asthma without significant differences between the levels observed and those expected in 9 of the 11 measurements carried out. The results indicate that sunny hours have a protective effect on the prevalence of asthma in schoolchildren.
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- 2011
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31. Early exposure to paracetamol or to antibiotics and eczema at school age: modification by asthma and rhinoconjunctivitis.
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Garcia-Marcos L, González-Díaz C, Garvajal-Urueña I, Pac-Sa MR, Busquets-Monge RM, Suárez-Varela MM, Batlles-Garrido J, Blanco-Quirós A, Varela AL, García-Hernández G, and Aguinaga-Ontoso I
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- Acetaminophen therapeutic use, Anti-Bacterial Agents therapeutic use, Child, Conjunctivitis, Eczema chemically induced, Eczema physiopathology, Family, Female, Humans, Male, Rhinitis, Socioeconomic Factors, Spain, Acetaminophen adverse effects, Anti-Bacterial Agents adverse effects, Asthma epidemiology, Eczema epidemiology, Population
- Abstract
The association between early exposure to paracetamol or to antibiotics and eczema is conflicting. This study aims to know whether the early exposure to those drugs is associated with eczema at school age, and whether the strength of the association is modified by the presence of asthma or rhinoconjunctivitis. Children aged 6-7 (n = 13908) from the International Study of Asthma and Allergies in Childhood in Spain provided data about current asthma, rhinoconjunctivitis and eczema. Parent-reported information was also obtained on paracetamol and antibiotic consumption during the first year of life. Logistic regression analysis with eczema as outcome and including exposure to paracetamol or to antibiotics, together with possible confounders, was carried out in the whole sample of children and in five different strata: no respiratory symptom and any respiratory symptom further subdivided into: asthma with rhinoconjunctivitis, asthma without rhinoconjunctivitis and rhinoconjunctivitis without asthma. In the whole sample, exposure to paracetamol was associated with eczema (aOR 1.56 [1.36-1.80]) as was antibiotic consumption (aOR 1.66 [1.43-1.92]). These associations did not substantially change after additionally adjusting for the other drug. A similar pattern was found among children without respiratory symptoms. In children with symptoms, adjusting for the other drug modified the association with paracetamol (aOR from 1.32 [1.03-1.71] to 1.09 [0.83-1.43]) but did not change that with antibiotics (aOR from 1.80 [1.38-2.35] to 1.81 [1.37-2.39]). Early exposure to paracetamol or to antibiotics is associated with an increased prevalence of eczema at school age. Asthma and/or rhinoconjunctivitis substantially modifies this association., (© 2010 John Wiley & Sons A/S.)
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- 2010
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32. Diet and prevalence of atopic eczema in 6 to 7-year-old schoolchildren in Spain: ISAAC phase III.
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Suárez-Varela MM, Alvarez LG, Kogan MD, Ferreira JC, Martínez Gimeno A, Aguinaga Ontoso I, González Díaz C, Arnedo Pena A, Domínguez Aurrecoechea B, Busquets Monge RM, Blanco Quiros A, Batlles Garrido J, García de Andoain N, Varela AL, García Merino A, Gimeno Clemente N, and Llopis González A
- Subjects
- Child, Cross-Sectional Studies, Diet, Mediterranean, Female, Humans, Male, Obesity complications, Prevalence, Spain epidemiology, Dermatitis, Atopic epidemiology, Diet
- Abstract
Background: The prevalence of atopic dermatitis (AD), a chronic skin disease, has increased substantially in recent decades, and different factors have been implicated in its etiology. Although dietary habits are being investigated, few conclusive findings have been reported. Nevertheless, increased consumption of polyunsaturated fatty acids (PUFA) and a diet poor in antioxidants have been related to AD., Objectives: The objectives of this study were to investigate the association between AD, the intake of different foods, and the effect of a Mediterranean diet among Spanish schoolchildren aged 6 to 7., Methods: We performed a cross-sectional study with 20 106 schoolchildren aged 6-7 years from 10 different areas of Spain. The participation rate was 76.50%. The prevalence of AD was assessed using the International Study of Asthma and Allergies in Childhood questionnaire and the criteria of the Spanish Academy of Dermatology. To calculate the Mediterranean diet score, we classified food into 2 groups: Mediterranean food, including fruit, seafood, vegetables, pulses, cereals, pasta, rice, and potatoes; and non-Mediterranean food, including meat, milk, and fast food., Results: Milk was negatively associated with AD. Butter and nuts also were negatively associated, although statistical significance was only reached when these foods were consumed 3 or more times a week., Conclusions: We found no association between the Mediterranean diet score and AD and a positive association between AD and obesity.
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- 2010
33. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II.
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Nagel G, Büchele G, Weinmayr G, Björkstén B, Chen YZ, Wang H, Nystad W, Saraclar Y, Bråbäck L, Batlles-Garrido J, Garcia-Hernandez G, and Weiland SK
- Subjects
- Asthma physiopathology, Bronchial Hyperreactivity physiopathology, Child, Female, Humans, Logistic Models, Male, Respiratory Function Tests, Respiratory Sounds immunology, Respiratory Sounds physiopathology, Retrospective Studies, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Time Factors, Asthma immunology, Breast Feeding, Bronchial Hyperreactivity immunology
- Abstract
The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).
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- 2009
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34. [Air pollution and recent symptoms of asthma, allergic rhinitis, and atopic eczema in schoolchildren aged between 6 and 7 years].
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Arnedo-Pena A, García-Marcos L, Carvajal Urueña I, Busquets Monge R, Morales Suárez-Varela M, Miner Canflanca I, Batlles Garrido J, Blanco Quirós A, López-Silvarrey Varela A, García Hernández G, Aguinaga Ontoso I, and González Díaz C
- Subjects
- Asthma etiology, Carbon Monoxide analysis, Child, Cough epidemiology, Dermatitis, Atopic etiology, Female, Humans, Male, Meteorological Concepts, Nitrogen Dioxide analysis, Particulate Matter analysis, Prevalence, Respiratory Sounds, Rhinitis, Allergic, Perennial etiology, Rhinitis, Allergic, Seasonal etiology, Spain epidemiology, Sulfur Dioxide analysis, Urban Population statistics & numerical data, Air Pollutants analysis, Air Pollution adverse effects, Asthma epidemiology, Dermatitis, Atopic epidemiology, Rhinitis, Allergic, Perennial epidemiology, Rhinitis, Allergic, Seasonal epidemiology
- Abstract
Objective: The objective of the study was to analyze the relationship between air pollutants and the prevalence of recent symptoms of asthma, allergic rhinitis, and atopic eczema in schoolchildren aged between 6 and 7 years., Patients and Methods: The prevalence of recent (previous 12 months) symptoms of allergic diseases was obtained by means of the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC), Spain, with the participation of 7 centers (Asturias, Barcelona, Bilbao, Cartagena, La Coruña, Madrid, and Valencia) and 20 455 schoolchildren aged between 6 and 7 years, from 2002 to 2003. The pollutant detection systems of the aforementioned centers provided the mean annual concentrations of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and total suspended particulate matter., Results: The annual average concentration of SO2 showed a significant association with a higher prevalence of recent severe asthma (adjusted odds ratio [aOR] between level-1 and level-3 pollution, 1.32; 95% confidence interval [CI], 1.01-1.73), rhinitis (aOR, 1.56; 95% CI, 1.39-1.75), and rhinoconjunctivitis (aOR, 1.70; 95% CI, 1.45-2.00). The annual average concentration of CO was associated with a higher prevalence of rhinitis (aOR, 1.65; 95% CI, 1.34-2.04), rhinoconjunctivitis (aOR, 1.76; 95% CI, 1.31-2.37), and eczema (aOR, 1.55; 95% CI, 1.17-2.04). The annual average concentration for NO2 and total suspended particulate matter showed inverse associations with the prevalence of nocturnal dry cough., Conclusions: Findings suggest that air pollutants such as SO2 and CO increase the risk of recent symptoms of asthma and allergic rhinitis in schoolchildren aged between 6 and 7 years in Spain.
- Published
- 2009
- Full Text
- View/download PDF
35. [Prevalence of atopic eczema and nutritional factors in 6-7 year old children].
- Author
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Morales Suárez-Varela MM, García-Marcos Alvarez L, González Díaz C, Arnedo Pena A, Domínguez Aurrecoechea B, Busquets Monge RM, Blanco Quiros A, Batlles Garrido J, Miner Canflanca I, López-Silvarrey Varela A, Martínez Gimeno A, Aguinagua Ontoso I, Llopis González A, and Jiménez López MC
- Subjects
- Age Factors, Chi-Square Distribution, Child, Clinical Trials, Phase III as Topic, Confidence Intervals, Cross-Over Studies, Female, Humans, Male, Prevalence, Sex Factors, Spain epidemiology, Surveys and Questionnaires, Dermatitis, Atopic epidemiology, Feeding Behavior
- Abstract
Objectives: To describe the prevalence of atopic eczema (AE) and to find the characteristics of the diet of children with AE., Design: Descriptive, transversal study., Setting: Primary schools., Main Measurements: The study used the standardized and validated questionnaire of the ISAAC phase III study, which finds the prevalence of AE in children and enables inter-centre comparison to be conducted. A questionnaire about food consumption was included. The prevalence ratio (PR) of AE and food consumption (95% confidence intervals) was calculated., Results: A total of 28 448 children aged 6-7 were included in the study. The prevalence of clinically diagnosed AE was 15.35% in boys and 15.24% in girls. The foods most often consumed were: dairy and cereals, followed by rice, pasta, and eggs. The least consumed were: butter, margarine, and fast food. The PR for children who consumed pasta was (PR=1.35), seafood (PR=1.28), cereals (PR=1.26), eggs (PR=1.13), and meat (PR=1.09)., Conclusions: The prevalence of AE in Spain was 15.3%, and was associated with food consumption. The consumption of dairy products, cereals, and olive oil was appropriate. The intake of fruit, vegetables, seafood, and legumes was below the recommended amounts. Future studies on the question are needed.
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- 2007
- Full Text
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36. Asthma attributable to atopy: does it depend on the allergen supply?
- Author
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Garcia-Marcos L, Garcia-Hernández G, Morales Suarez-Varela M, Batlles Garrido J, and Castro-Rodriguez JA
- Subjects
- Child, Female, Humans, Male, Risk Factors, Skin Tests, Spain, Surveys and Questionnaires, Asthma etiology, Asthma immunology, Environmental Exposure, Hypersensitivity, Immediate immunology, Respiratory Sounds immunology
- Abstract
The use of the population attributable fraction (PAF) of asthma owing to atopy has not been widely used in epidemiological studies on childhood asthma, especially to compare regions of the same country. The present study includes 1039 children from Cartagena, Spain (Mediterranean coast) and 663 from Madrid (centre of Spanish plateau) using the ISAAC phase II methodology (questionnaire and prick test to the most common allergens). While there were no differences in asthma symptoms between school children (aged 10-11 yr) from Madrid and Cartagena, atopy to any allergen was significantly higher in those from Madrid (40.9% vs. 29.3%, respectively, p < 0.0001). However, children from Madrid were mainly positive to pollen allergy whereas those from Cartagena were positive for mite allergy. PAF of all the different asthma symptoms owing to atopy (any positive skin test) and PAF of current wheezing owing to a more severe atopy (three positive wheals) were higher in children from Cartagena than those from Madrid (45.5% vs. 28.6% and 14.2% vs. 6.2%, respectively). Per cent of previous year wheezing attributable to atopy to specific allergens varied among those cities and was higher for D. pteronissinus, D. farinae, cat, and olive tree in children from Cartagena, and--conversely--higher for mixed grasses, mixed trees and Alternaria in those from Madrid. All of these differences remained significant even after adjusting for risk factors. PAF for asthma owing to atopy could be very different within the same country, probably depending on the allergen supply which may depend on environmental factors such as the climate.
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- 2007
- Full Text
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37. [Time trends and geographical variations in the prevalence of symptoms of allergic rhinitis in 6-7-year-old children from eight areas of Spain according to the ISAAC].
- Author
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Arnedo-Pena A, García-Marcos L, García Hernández G, Aguinagua Ontoso I, González Díaz C, Morales Suárez-Varela M, Domínguez Aurrecoechea B, Busquets Monge R, Blanco Quiros A, Batlles Garrido J, Miner Kanflanka I, and López-Silvarrey Varela A
- Subjects
- Child, Female, Humans, Male, Prevalence, Spain epidemiology, Rhinitis, Allergic, Perennial epidemiology
- Abstract
Background: Phase III of the International Study of Asthma and other Allergies in Childhood (ISAAC) was carried out in schoolchildren aged 6-7 years from eight areas of Spain to estimate time trends and geographic variations in the prevalence of symptoms of allergic rhinitis (AR)., Material and Method: A standard and validated questionnaire was used following ISAAC methodology and was completed by the schoolchildren's parents. The prevalence of symptoms of AR in Phase I (1993-1994) and Phase III (2001-2002) was compared. Eight centers participated: Asturias, Barcelona, Bilbao, Cartagena, Castellón, Madrid, Pamplona and Valencia. Poisson regression was used in the analysis., Results: A total of 25,113 schoolchildren were studied with a median participation of 81.7 %. In all centers, AR symptoms tended to increase, with a prevalence ratio of rhinoconjunctivitis in the previous year of 1.61 (95 % confidence interval: 1.48-1.76) when both phases, adjusted by gender, center, and seasonal variation, were compared. The prevalence of AR symptoms was higher in boys than in girls. Wide variations in the prevalence of AR were observed across centers with a higher prevalence in Asturias, Madrid, Cartagena and Bilbao. Lower prevalences were reported in Barcelona, Castellón and Pamplona., Conclusions: There seems to have been a general increase in AR symptoms. Substantial variations between centers suggested that there may be local differences in risk factors. Intense research will be required for satisfactory preventive actions.
- Published
- 2005
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38. [Time trends in prevalence of symptoms of allergic rhinitis in 13-14 year-old schoolchildren in 8 areas of Spain between 1993-1994 and 2001-2002 according to the International Study of Asthma and Allergies in Childhood (ISAAC)].
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Arnedo-Pena A, García-Marcos L, Blanco-Quirós A, Martínez Gimeno A, Aguinaga Ontoso I, González Díaz C, Díaz Vázquez C, Busquets-Monge R, Morales Suárez-Varela M, Batlles Garrido J, López-Silvarrey Varela A, and García de Andoin N
- Subjects
- Adolescent, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Risk Factors, Spain epidemiology, Rhinitis, Allergic, Perennial epidemiology
- Abstract
Background and Objective: Our goal was to estimate the time trends in the prevalence of symptoms of allergic rhinitis (AR) and its geographic variations., Population and Method: During 2001-2002, the phase 3 of ISAAC study was carried out, and a comparison with the phase 1 (1993-1994) was done. This cross sectional study included 30,046 schoolchildren 13-14 years-old from 9 centers (Asturias, Barcelona, Bilbao, Cartagena, Castellon, Madrid, Pamplona, Valencia, and Valladolid). A questionnaire about rhinitis symptoms self-administered to schoolchildren was used at schools and institutes with a participation rate of 100% to 75.8%., Results: A divergent time trend of AR prevalence symptoms was observed with a decrease in Barcelona and Bilbao, a stabilization in Cartagena, Pamplona, and Valencia, and an increase in Castellon; Madrid and Valladolid; however, there was an overall increase in nasal allergy. The prevalence of rhinoconjunctivitis in the past year (Prevalence Ratio [PR] = 1,13; 95% Confidence Interval [CI], 1.07-1.19) and nasal allergy ever (PR = 1.22; 95% CI, 1.15-1.30) increased after adjusting for gender, center and season change. The prevalence of rhinoconjunctivitis and nasal allergy varied according to centres, Madrid, Asturias, Cartagena and Bilbao exhibiting the higher prevalence. Taken as a whole, these data indicate a middle prevalence of AR when compared with other countries following an ISAAC methodology., Conclusions: Two patterns of time trend of prevalence of symptoms of AR were observed. The investigation of risk factors at local level could be important in order to undertake preventive measures.
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- 2004
- Full Text
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39. [International Study of Asthma and Allergies in Childhood (ISAAC) Phase II: Methodology and results of the participation rate in Spain].
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García-Marcos Alvarez L, Martínez Torres A, Batlles Garrido J, Morales Suárez-Varela M, García Hernández G, and Escribano Montaner A
- Subjects
- Child, Health Surveys, Humans, Spain epidemiology, Asthma epidemiology, Hypersensitivity epidemiology
- Abstract
Background: The ISAAC phase I results have supplied valuable information on the prevalence of asthma and allergy in childhood throughout the world., Objectives: To describe the implementation and participation rate of normal children in each test performed in phase II of the ISAAC in the four Spanish cities participating the study, and to establish the influence of type of school and geographical situation (in a polluted or unpolluted area) in Cartagena., Methods: The ISAAC phase II included a questionnaire on symptoms, risk factors and treatment, skin examination, skin-prick test, bronchial challenge test, total and specific IgE measurement, as well as mite and bacterial endotoxin determination in house dust. The questionnaire was distributed with a letter requesting authorization from the parents in primary schools (fourth and fifth grades) in sufficient number to achieve approximately 1,000 skin prick-test authorizations in each city., Results: The participation rate for the questionnaire, skin examination, skin-prick test, blood extraction, bronchial challenge test, and dust collection was, respectively, for each city: Cartagena: 58.9, 49.2, 43.2, 33.1, 39.9 and 29.8 %; Almería: 42.5, 40.6, 39.1, 39.1 and 37.6 %; Valencia: 43.7, 30.4, 23.5, 21.5, 20.1 and 17.1 %; Madrid: 53.2, 40.8, 38.6, 27.6, 30.6 and 21.1 %. In Cartagena, participation was significantly higher in private schools receiving a state subsidy and in those in unpolluted areas., Conclusions: The participation rate was highly variable and lower than that among the European centres that have already completed the study. The rate was significantly influenced by geographical area and type of school.
- Published
- 2001
40. [Perinatal history and hospitalization for bronchiolitis. A comparison with the impact-RSV Study Group].
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Bonillo Perales A, DíezDelgado Rubio J, Ortega Montes A, Infante Márquez P, Jiménez Liria M, Batlles Garrido J, and López Muñoz J
- Subjects
- Humans, Incidence, Infant, Infant, Newborn, Infant, Premature, Diseases epidemiology, Retrospective Studies, Risk Factors, Bronchiolitis, Viral therapy, Hospitalization statistics & numerical data, Infant, Premature, Diseases therapy, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections therapy, Respiratory Syncytial Virus, Human
- Abstract
Aim: To describe the rate of hospitalization for bronchiolitis among newborn infants in our environment, to evaluate the influence of prematurity and other perinatal conditions on hospitalization for bronchiolitis, and to compare our data with those of the Impact-RSV Study Group., Materials and Methods: Descriptive studying based on analysis of the perinatal data of all neonates and patients hospitalized for bronchiolitis during a 3-year period., Results: Among 12,895 newborn infants, 455 (3.52 %) required hospitalization for bronchiolitis. The hospitalization rate for bronchiolitis was 3.18 % among term infants, 8.6 % among preterm infants, 9.8 % among infants with congenital heart disease and 21.1 % among preterm infants who required mechanical ventilation during the neonatal period. Intensive care unit admission was associated with postnatal age under 6 weeks (OR: 1.68; 95 % CI: 1.04-8.19; p 5 0.04) and prematurity (OR: 2,67; 95 % CI: 1.01-7.56; p 5 0.006). The hospitalization rate for bronchiolitis was 40 % lower in our neonatal population than in that of the Impact-RSV Study Group. When infants with bronchopulmonary dysplasia, congenital heart disease and mechanical ventilation during the neonatal period were excluded, the hospitalization rate for respiratory syncytial virus (RSV) was not significantly different between infants born at < weeks' gestation and those born at < 32 weeks' gestation and those born at 32-35 weeks' gestation (3.4% vs 4.3%; p>0.10)., Conclusions: Neonatal mechanical ventilation, bronchopulmonary dysplasia and congenital heart disease are more closely associated with hospitalization for RSV(1) bronchiolitis and mean length of stay than with gestational age.
- Published
- 2000
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