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2. Association of Male Sex With Worse Right Ventricular Function and Survival in Pulmonary Hypertension in the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Cohort

Author

Shelburne, Nicholas J., Nian, Hui, Beck, Gerald J., Casanova, Nancy G., Desai, Ankit A., DuBrock, Hilary M., Erzurum, Serpil, Frantz, Robert P., Hassoun, Paul M., Hill, Nicholas S., Horn, Evelyn M., Jacob, Miriam S., Jellis, Christine L., Joseloff, Elizabeth, Kwon, Deborah H., Larive, A. Brett, Leopold, Jane A., Park, Margaret M., Rischard, Franz P., Rosenzweig, Erika B., Vanderpool, Rebecca R., Yu, Chang, and Hemnes, Anna R.

Published
2024
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4. A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Author

Inker, Lesley A, Couture, Sara J, Tighiouart, Hocine, Abraham, Alison G, Beck, Gerald J, Feldman, Harold I, Greene, Tom, Gudnason, Vilmundur, Karger, Amy B, Eckfeldt, John H, Kasiske, Bertram L, Mauer, Michael, Navis, Gerjan, Poggio, Emilio D, Rossing, Peter, Shlipak, Michael G, Levey, Andrew S, Collaborators, CKD-EPI GFR, Andresdottir, Margret B, Gudmundsdottir, Hrefna, Indridason, Olafur S, Palsson, Runolfur, Kimmel, Paul, Weir, Matt, Kalil, Roberto, Pesavento, Todd, Porter, Anna, Taliercio, Jonathan, Hsu, Chi-yuan, Chen, Jing, Sinkeler, Steef, Wyatt, Christina, Krishnasami, Zipporah, Hellinger, James, Margolick, Joseph, Kingsley, Lawrence, Witt, Mallory, Wolinsky, Steven, Shafi, Tariq, Post, Wendy, Doria, Alessandro, and Parving, Hans-Henrik

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Renal and urogenital, Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Black People, Case-Control Studies, Chromium Radioisotopes, Creatinine, Cystatin C, Edetic Acid, Female, Glomerular Filtration Rate, Humans, Intramolecular Oxidoreductases, Iohexol, Iothalamic Acid, Lipocalins, Male, Middle Aged, Renal Insufficiency, Chronic, Reproducibility of Results, Severity of Illness Index, White People, Young Adult, beta 2-Microglobulin, CKD-EPI GFR Collaborators, African American, Black race, GFR estimation, Glomerular filtration rate, bias, creatinine, cystatin C, estimating equations, filtration marker, kidney disease diagnosis, laboratory testing, race, race-based medicine, renal function, β(2)-microglobulin, β-trace protein, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale and objectiveGlomerular filtration rate (GFR) estimation based on creatinine and cystatin C (eGFRcr-cys) is more accurate than estimated GFR (eGFR) based on creatinine or cystatin C alone (eGFRcr or eGFRcys, respectively), but the inclusion of creatinine in eGFRcr-cys requires specification of a person's race. β2-Microglobulin (B2M) and β-trace protein (BTP) are alternative filtration markers that appear to be less influenced by race than creatinine is.Study designStudy of diagnostic test accuracy.Setting and participantsDevelopment in a pooled population of 7 studies with 5,017 participants with and without chronic kidney disease. External validation in a pooled population of 7 other studies with 2,245 participants.Tests comparedPanel eGFR using B2M and BTP in addition to cystatin C (3-marker panel) or creatinine and cystatin C (4-marker panel) with and without age and sex or race.OutcomesGFR measured as the urinary clearance of iothalamate, plasma clearance of iohexol, or plasma clearance of [51Cr]EDTA.ResultsMean measured GFRs were 58.1 and 83.2 mL/min/1.73 m2, and the proportions of Black participants were 38.6% and 24.0%, in the development and validation populations, respectively. In development, addition of age and sex improved the performance of all equations compared with equations without age and sex, but addition of race did not further improve the performance. In validation, the 4-marker panels were more accurate than the 3-marker panels (P < 0.001). The 3-marker panel without race was more accurate than eGFRcys (percentage of estimates greater than 30% different from measured GFR [1 - P30] of 15.6% vs 17.4%; P = 0.01), and the 4-marker panel without race was as accurate as eGFRcr-cys (1 - P30 of 8.6% vs 9.4%; P = 0.2). Results were generally consistent across subgroups.LimitationsNo representation of participants with severe comorbid illness and from geographic areas outside of North America and Europe.ConclusionsThe 4-marker panel eGFR is as accurate as eGFRcr-cys without requiring specification of race. A more accurate race-free eGFR could be an important advance.

Published
2021

5. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., Bernardo, Roberto J., Vanderpool, Rebecca R., Kwon, Deborah H., Acharya, Tushar, Park, Margaret M., Katrynuik, Austin, Insel, Michael, Kubba, Saad, Badagliacca, Roberto, Larive, A. Brett, Naeije, Robert, Garcia, Joe G.N., Beck, Gerald J., Erzurum, Serpil C., Frantz, Robert P., Hassoun, Paul M., Hemnes, Anna R., Hill, Nicholas S., Horn, Evelyn M., Leopold, Jane A., Rosenzweig, Erika B., Tang, W.H. Wilson, and Wilcox, Jennifer D.

Published
2023
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6. Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease

Author

Hemnes, Anna R., Leopold, Jane A., Radeva, Milena K., Beck, Gerald J., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Rosenzweig, Erika B., Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Desai, Ankit A., Dubrock, Hilary M., Erzurum, Serpil C., Finet, J. Emanuel, Frantz, Robert P., Garcia, Joe G.N., Geraci, Mark W., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Highland, Kristin B., Hill, Nicholas S., Hu, Bo, Kwon, Deborah H., Jacob, Miriam S., Jellis, Christine L., Larive, A. Brett, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., McCarthy, Kevin, Mehra, Reena, Nawabit, Rawan, Newman, John H., Olman, Mitchell A., Park, Margaret M., Ramos, Jose A., Renapurkar, Rahul D., Rischard, Franz P., Sherer, Susan G., Tang, W.H. Wilson, Thomas, James D., Vanderpool, Rebecca R., Waxman, Aaron B., Wilcox, Jennifer D., Yuan, Jason X.-J., and Horn, Evelyn M.

Published
2022
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7. Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials

Author

Chan, Christopher T, Kaysen, George A, Beck, Gerald J, Li, Minwei, Lo, Joan, Rocco, Michael V, and Kliger, Alan S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Prevention, Clinical Research, Kidney Disease, Clinical Trials and Supportive Activities, Adult, Biomarkers, Cohort Studies, Female, Humans, Hypertrophy, Left Ventricular, Kidney Failure, Chronic, Male, Middle Aged, Randomized Controlled Trials as Topic, Remission Induction, Renal Dialysis, Frequent hemodialysis, Cardiac biomarkers, Klotho, Markers of collagen turnover, Left ventricular hypertrophy, Copeptin, Brain natriuretic peptide, FHN Trials, Copeptin, Left ventricular hypertrophy , Clinical Sciences, Urology & Nephrology, Clinical sciences
Abstract

BackgroundRegression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials.MethodsThis was a post hoc observational cohort study. We hypothesized LVH regression with frequent HD was associated with a different cardiovascular biomarker profile. Regressors were defined as patients who achieved a reduction of more than 10% in LVM at 12 months. Progressors were defined as patients who had a minimum of 10% increase in LVM at 12 months.ResultsAmong 332 randomized patients, 243 had biomarker data available. Of these, 121 patients did not progress or regress, 77 were regressors, and 45 were progressors. Mean LVM change differed between regressors and progressors by -65.6 (-74.0 to -57.2) g, p < 0.001. Regressors had a median (interquartile range) increase in dialysis frequency (from 3.0 [3.0-3.0] to 4.9 [3-5.7] per week, p = 0.001) and reductions in pre-dialysis systolic (from 149.0 [136.0-162.0] to 136.0 [123.0-152.0] mm Hg, p < 0.001) and diastolic (from 83.0 [71.0-91.0] to 76.0 [68.0-84.0] mm Hg, p < 0.001) blood pressures. Klotho levels increased in regressors versus progressors (76.9 [10.5-143.3] pg/mL, p = 0.024). Tissue inhibitors of metalloproteinase (TIMP)-2 levels fell in regressors compared to progressors (-7,853 [-14,653 to -1,052] pg/mL, p = 0.024). TIMP-1 and log (brain natriuretic -peptide [BNP]) levels also tended to fall in regressors. Changes in LVM correlated inversely with changes in klotho (r = -0.24, p = 0.014). -Conclusions: Markers of collagen turnover and changes in klotho levels are potential novel pathways associated with regression of LVH in the dialysis population, which will require further prospective validation.

Published
2018

9. Thyroid function in end stage renal disease and effects of frequent hemodialysis

Author

Lo, Joan C, Beck, Gerald J, Kaysen, George A, Chan, Christopher T, Kliger, Alan S, Rocco, Michael V, Li, Minwei, Chertow, Glenn M, and Study, for the FHN

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Assistive Technology, Kidney Disease, Clinical Research, Bioengineering, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Aged, Female, Humans, Hypothyroidism, Kidney Failure, Chronic, Male, Middle Aged, Renal Dialysis, Thyroid Function Tests, Thyroid Gland, FHN Study, End-stage renal disease, daily dialysis, hypothyroidism, nocturnal dialysis, thyroid, Urology & Nephrology, Clinical sciences
Abstract

IntroductionEnd-stage renal disease (ESRD) is associated with perturbations in thyroid hormone concentrations and an increased prevalence of hypothyroidism. Few studies have examined the effects of hemodialysis dose or frequency on endogenous thyroid function.MethodsWithin the Frequent Hemodialysis Network (FHN) trials, we examined the prevalence of hypothyroidism in patients with ESRD. Among those with endogenous thyroid function (without overt hyper/hypothyroidism or thyroid hormone supplementation), we examined the association of thyroid hormone concentration with multiple parameters of self-reported health status, and physical and cognitive performance, and the effects of hemodialysis frequency on serum thyroid stimulating hormone (TSH), free thyroxine (FT4), and free tri-iodothyronine (FT3) levels. Conventional thrice-weekly hemodialysis was compared to in-center (6 d/wk) hemodialysis (Daily Trial) and Nocturnal (6 nights/wk) home hemodialysis (Nocturnal Trial) over 12 months.FindingsAmong 226 FHN Trial participants, the prevalence of hypothyroidism was 11% based on thyroid hormone treatment and/or serum TSH ≥8 mIU/mL. Among the remaining 195 participants (147 Daily, 48 Nocturnal) with endogenous thyroid function, TSH concentrations were modestly (directly) correlated with age (r = 0.16, P = 0.03) but not dialysis vintage. Circulating thyroid hormone levels were not associated with parameters of health status or physical and cognitive performance. Furthermore, frequent in-center and nocturnal hemodialysis did not significantly change (baseline to month 12) TSH, FT4, or FT3 concentrations in patients with endogenous thyroid function.DiscussionAmong patients receiving hemodialysis without overt hyper/hypothyroidism or thyroid hormone treatment, thyroid indices were not associated with multiple measures of health status and were not significantly altered with increased dialysis frequency.

Published
2017

10. Hyperprolactinemia in end‐stage renal disease and effects of frequent hemodialysis

Author

Lo, Joan C, Beck, Gerald J, Kaysen, George A, Chan, Christopher T, Kliger, Alan S, Rocco, Michael V, Chertow, Glenn M, and Study, for the FHN

Subjects
Bioengineering, Prevention, Clinical Research, Kidney Disease, Assistive Technology, Clinical Trials and Supportive Activities, Renal and urogenital, Good Health and Well Being, Female, Humans, Hyperprolactinemia, Kidney Failure, Chronic, Male, Middle Aged, Quality of Life, Renal Dialysis, FHN Study, Prolactin, daily dialysis, end stage renal disease, nocturnal dialysis, pituitary, Clinical Sciences, Urology & Nephrology
Abstract

IntroductionEnd-stage renal disease is associated with elevations in circulating prolactin concentrations, but the association of prolactin concentrations with intermediate health outcomes and the effects of hemodialysis frequency on changes in serum prolactin have not been examined.MethodsThe FHN Daily and Nocturnal Dialysis Trials compared the effects of conventional thrice weekly hemodialysis with in-center daily hemodialysis (6 days/week) and nocturnal home hemodialysis (6 nights/week) over 12 months and obtained measures of health-related quality of life, self-reported physical function, mental health and cognition. Serum prolactin concentrations were measured at baseline and 12-month follow-up in 70% of the FHN Trial cohort to examine the associations among serum prolactin concentrations and physical, mental and cognitive function and the effects of hemodialysis frequency on serum prolactin.FindingsAmong 177 Daily Trial and 60 Nocturnal Trial participants with baseline serum prolactin measurements, the median serum prolactin concentration was 65 ng/mL (25th-75th percentile 48-195 ng/mL) and 81% had serum prolactin concentrations >30 ng/mL. While serum prolactin was associated with sex (higher in women), we observed no association between baseline serum prolactin and age, dialysis vintage, and baseline measures of physical, mental and cognitive function. Furthermore, there was no significant effect of hemodialysis frequency on serum prolactin in either of the two trials.DiscussionSerum prolactin concentrations were elevated in the large majority of patients with ESRD, but were not associated with several measures of health status. Circulating prolactin levels also do not appear to decrease in response to more frequent hemodialysis over a one-year period.

Published
2017

11. Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes

Author

Courcoulas, Anita P., primary, Patti, Mary Elizabeth, additional, Hu, Bo, additional, Arterburn, David E., additional, Simonson, Donald C., additional, Gourash, William F., additional, Jakicic, John M., additional, Vernon, Ashley H., additional, Beck, Gerald J., additional, Schauer, Philip R., additional, Kashyap, Sangeeta R., additional, Aminian, Ali, additional, Cummings, David E., additional, and Kirwan, John P., additional

Published
2024
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12. Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation

Author

Feldman, H., Dember, L., Farber, A., Kaufman, J., Stern, L., LeSage, P., Kivork, C., Soares, D., Malikova, M., Allon, M., Young, C., Taylor, M., Woodard, L., Mangadi, K., Roy-Chaudhury, P., Munda, R., Lee, T., Alloway, R., El-Khatib, M., Canaan, T., Pflum, A., Thieken, L., Campos-Naciff, B., Huber, T., Berceli, S., Jansen, M., McCaslin, G., Trahan, Y., Vazquez, M., Vongpatanasin, W., Davidson, I., Hwang, C., Lightfoot, T., Livingston, C., Valencia, A., Dolmatch, B., Fenves, A., Hawkins, N., Cheung, A.K., Kraiss, L., Kinikini, D., Treiman, G., Ihnat, D., Sarfati, M., Shiu, Y.T., Terry, C., Lavasani, I., Maloney, M., Schlotfeldt, L., Himmelfarb, J., Buchanan, C., Clark, C., Crawford, C., Hamlett, J., Kundzins, J., Manahan, L., Wise, J., Beck, G., Gassman, J., Greene, T., Imrey, P., Li, L., Alster, J., Li, M., MacKrell, J., Radeva, M., Weiss, B., Wiggins, K., Alpers, C., Hudkins, K., Wietecha, T., Robbin, M., Umphrey, H., Alexander, L., Abts, C., Belt, L., Vita, J., Hamburg, N., Duess, M., Levit, A., Higgins, H., Ke, S., Mandaci, O., Snell, C., Gravley, J., Behnken, S., Mortensen, R., Chertow (Chair), G., Besarab, A., Brayman, K., Diener-West, M., Harrison, D., Inker, L., Louis, T., McClellan, W., Rubin, J., Kusek, J., Star, R., Kubiak, Rachel W., Zelnick, Leila R., Hoofnagle, Andy N., Alpers, Charles E., Terry, Christi M., Shiu, Yan-Ting, Cheung, Alfred K., de Boer, Ian H., Robinson-Cohen, Cassianne, Allon, Michael, Dember, Laura M., Feldman, Harold I., Himmelfarb, Jonathan, Huber, Thomas S., Roy-Chaudhury, Prabir, Vazquez, Miguel A., Kusek, John W., Beck, Gerald J., Imrey, Peter B., and Kestenbaum, Bryan

Published
2019
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13. Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

Author

Sevillano, Angel, Kamper, Anne-Lise, van Zuilen, Arjan D., Brenner, Barry M., Maes, Bart, Ihle, Benno U., Barret, Brendan, Leung, CB, Szeto, CC, Fitzner, Christina, Wanner, Christoph, Pozzi, Claudio, Montagnino, Claudio Ponticelli, Xie, Di, de Zeeuw, Dick, Lewis, Edmund, Verde, Eduardo, Gutierrez, Eduardo, Imai, Enyu, Hou, Fan Fan, Caravaca, Fernando, Fervenza, Fernando C., Locatelli, Francesco, Schena, Francesco Paolo, Kobayashi, Fumiaki, Moroni, Gabriella, Becker, Gavin J., Beck, Gerald J., Appel, Gerald B., Frisch, Gershon, van Essen, GG, Maschio, Giuseppe, Remuzzi, Giuseppe, Montogrino, Giuseppe, Parving, Hans-Henrik, Heerspink, Hiddo J.L., Makino, Hirofumi, Jehan, Imitiaz, Wetzels, Jack F.M., Donadio, James, Dwyer, Jamie, van den Brand, Jan, Kusek, John, Lachin, John M., Luño, Jose, Lewis, Julia B., Floege, Jürgen, Abebe, Kaleab Z., Chow, KM, Hunsicker, Lawrence G., del Vecchio, Lucia, Carlo, Manno, Praga, Manuel, Goicoechea, Marian, von Eynatten, Maximilian, Poulter, Neil, Chaturvedi, Nish, Passerini, Patrizia, de Jong, Paul E., Blankestijn, Peter J., Li, Philip, Ruggenenti, Piero, Zucchelli, Pietro, Kincaid-Smith, Priscilla S., Hilgers, Ralf-Dieter, Estacio, Raymond O., Rohde, Richard D., Katafuchi, Ritsuko, Toto, Robert D., Schrier, Robert W., Rodby, Roger A., Perrone, Ronald D., Ito, Sadayoshi, Klahr, Saulo, Andrulli, Simeone, Strandgaard, Svend, Chan, Tak Mao, Hannedouche, Thierry P., Rauen, Thomas, Greene, Tom, Verdalles, Ursula, Perkovic, Vlado, Keane, William, Heerspink, Hiddo J L, Tighiouart, Hocine, Gansevoort, Ron T, Coresh, Josef, Simon, Andrew L, Lewis, Julia B, Levey, Andrew S, and Inker, Lesley A

Published
2019
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15. Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension

Author

Lowery, Megan M., primary, Hill, Nicholas S., additional, Wang, Lu, additional, Rosenzweig, Erika B., additional, Bhat, Aparna, additional, Erzurum, Serpil, additional, Finet, J. Emanuel, additional, Jellis, Christine L., additional, Kaur, Sunjeet, additional, Kwon, Deborah H., additional, Nawabit, Rawan, additional, Radeva, Milena, additional, Beck, Gerald J., additional, Frantz, Robert P., additional, Hassoun, Paul M., additional, Hemnes, Anna R., additional, Horn, Evelyn M., additional, Leopold, Jane A., additional, Rischard, Franz P., additional, Mehra, Reena, additional, Hill, N., additional, Xiao, L., additional, Fu, Y.-P., additional, Postow, L., additional, Schmetter, B., additional, Stanton, K., additional, Tian, X., additional, Gray, M., additional, Wong, B., additional, Leopold, J., additional, Waxman, A., additional, DiCarli, M., additional, Lawler, L., additional, Maron, B., additional, Segrera, S., additional, Systrom, D., additional, Yu, P., additional, Rosenzweig, E.B., additional, Arcasoy, S., additional, Brady, D., additional, Chung, W., additional, Payne, D., additional, Grunig, G., additional, Haythe, J., additional, Krishnan, U., additional, Horn, E., additional, Akat, K., additional, Borczuk, A., additional, Devereux, R., additional, Gordon, J., additional, Kaner, R., additional, Karas, M., additional, Min, J., additional, Narula, N., additional, Ricketts, M., additional, Sobol, I., additional, Spiera, R., additional, Singh, H., additional, Tuschl, T., additional, Weinsaft, J., additional, Hassoun, P., additional, Mathai, S., additional, Barnes, K., additional, Damico, R., additional, Enobun, B., additional, Gao, L., additional, Halushka, M., additional, Kass, D., additional, Kolb, T., additional, Lin, T., additional, Tedford, R., additional, Zimmerman, S., additional, Frantz, R., additional, Behfar, A., additional, Block, L., additional, Borlaug, B., additional, Durst, L., additional, Foley, T., additional, Hammer, T., additional, Johnson, B., additional, Johnson, G., additional, Kane, G., additional, Krowka, M., additional, McNallan, A., additional, Olson, T., additional, Redfield, M., additional, Rohwer, K., additional, Terzic, A., additional, Williamson, E., additional, Rischard, F., additional, Yuan, J., additional, Abidov, A., additional, Garcia, J., additional, Cordery, A., additional, Desai, A., additional, Erickson, H., additional, Hansen, L., additional, Khalpey, Z., additional, Knox, K., additional, Lussier, Y., additional, Simon, M., additional, Vanderpool, R., additional, Hemnes, A., additional, Newman, J., additional, Austin, E., additional, Brittain, E., additional, Cunningham, J., additional, LaRochelle, C., additional, Pugh, M., additional, Robbins, I., additional, Wheeler, L., additional, Beck, G., additional, Erzurum, S., additional, Aldred, M., additional, Asosingh, K., additional, Barnard, J., additional, Collart, C., additional, Comhair, S., additional, DiFilippo, F., additional, Drinko, J., additional, Dweik, R., additional, Flinn, A., additional, Geraci, M., additional, Hu, B., additional, Jaber, W., additional, Jacob, M., additional, Jellis, C., additional, Kalhan, S., additional, Kassimatis, K., additional, Kirsop, J., additional, Koo, M., additional, Kwon, D., additional, Larive, B., additional, Lempel, J., additional, Li, M., additional, MacKrell, J., additional, Matuska, B., additional, McCarthy, K., additional, Mehra, R., additional, Neumann, D., additional, Nawabit, R., additional, Olman, M., additional, Park, M., additional, Radeva, M., additional, Sharp, J., additional, Sherer, S., additional, Tang, W., additional, Thomas, J., additional, Wiggins, K., additional, Willard, B., additional, Rounds, S., additional, Benza, R., additional, Bull, T., additional, Cadigan, J., additional, Fang, J., additional, Gomberg-Maitland, M., additional, and Page, G., additional

Published
2023
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16. Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

Author

Simpson, Catherine E., primary, Ambade, Anjira S., additional, Harlan, Robert, additional, Roux, Aurelie, additional, Aja, Susan, additional, Graham, David, additional, Shah, Ami A., additional, Hummers, Laura K., additional, Hemnes, Anna R., additional, Leopold, Jane A., additional, Horn, Evelyn M., additional, Berman-Rosenzweig, Erika S., additional, Grunig, Gabrielle, additional, Aldred, Micheala A., additional, Barnard, John, additional, Comhair, Suzy A.A., additional, Tang, W. H. Wilson, additional, Griffiths, Megan, additional, Rischard, Franz, additional, Frantz, Robert P., additional, Erzurum, Serpil C., additional, Beck, Gerald J., additional, Hill, Nicholas S., additional, Mathai, Stephen C., additional, Hassoun, Paul M., additional, and Damico, Rachel L., additional

Published
2023
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18. Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD

Author

Appel, Lawrence J., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Liu, Xun, Foster, Meredith C., Tighiouart, Hocine, Anderson, Amanda H., Beck, Gerald J., Contreras, Gabriel, Coresh, Josef, Eckfeldt, John H., Feldman, Harold I., Greene, Tom, Hamm, L. Lee, Horwitz, Edward, Lewis, Julia, Ricardo, Ana C., Shou, Haochang, Townsend, Raymond R., Weir, Matthew R., Inker, Lesley A., and Levey, Andrew S.

Published
2016
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19. GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD

Author

Inker, Lesley A., Tighiouart, Hocine, Coresh, Josef, Foster, Meredith C., Anderson, Amanda H., Beck, Gerald J., Contreras, Gabriel, Greene, Tom, Karger, Amy B., Kusek, John W., Lash, James, Lewis, Julia, Schelling, Jeffrey R., Navaneethan, Sankar D., Sondheimer, James, Shafi, Tariq, and Levey, Andrew S.

Published
2016
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20. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., primary, Bernardo, Roberto J., additional, Vanderpool, Rebecca R., additional, Kwon, Deborah H., additional, Acharya, Tushar, additional, Park, Margaret M, additional, Katrynuik, Austin, additional, Insel, Michael, additional, Kubba, Saad, additional, Badagliacca, Roberto, additional, Larive, A Brett, additional, Naeije, Robert, additional, Garcia, Joe G.N., additional, Beck, Gerald J, additional, Erzurum, Serpil C, additional, Frantz, Robert P, additional, Hassoun, Paul M, additional, Hemnes, Anna R, additional, Hill, Nicholas S, additional, Horn, Evelyn M, additional, Leopold, Jane A, additional, Rosenzweig, Erika B., additional, Tang, W.H. Wilson, additional, and Wilcox, Jennifer D., additional

Published
2023
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23. Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation

Author

Li, Yingnan, primary, He, Yong, additional, Falzon, Isabelle, additional, Fairbourn, Brayden, additional, Tingey, Spencer, additional, Imrey, Peter B., additional, Radeva, Milena K., additional, Beck, Gerald J., additional, Gassman, Jennifer J., additional, Roy-Chaudhury, Prabir, additional, Berceli, Scott A., additional, Cheung, Alfred K., additional, Shiu, Yan-Ting, additional, Feldman, H., additional, Dember, L., additional, Farber, A., additional, Kaufman, J., additional, Stern, L., additional, LeSage, P., additional, Kivork, C., additional, Soares, D., additional, Malikova, M., additional, Allon, M., additional, Young, C., additional, Taylor, M., additional, Woodard, L., additional, Mangadi, K., additional, Roy-Chaudhury, P., additional, Munda, R., additional, Lee, T., additional, Alloway, R., additional, El-Khatib, M., additional, Canaan, T., additional, Pflum, A., additional, Thieken, L., additional, Campos-Naciff, B., additional, Huber, T., additional, Berceli, S., additional, Jansen, M., additional, McCaslin, G., additional, Trahan, Y., additional, Vazquez, M., additional, Vongpatanasin, W., additional, Davidson, I., additional, Hwang, C., additional, Lightfoot, T., additional, Livingston, C., additional, Valencia, A., additional, Dolmatch, B., additional, Fenves, A., additional, Hawkins, N., additional, Cheung, A., additional, Kraiss, L., additional, Kinikini, D., additional, Treiman, G., additional, Ihnat, D., additional, Sarfati, M., additional, Lavasani, I., additional, Maloney, M., additional, Schlotfeldt, L., additional, Himmelfarb, J., additional, Buchanan, C., additional, Clark, C., additional, Crawford, C., additional, Hamlett, J., additional, Kundzins, J., additional, Manahan, L., additional, Wise, J., additional, Beck, G., additional, Gassman, J., additional, Greene, T., additional, Imrey, P., additional, Li, L., additional, Alster, J., additional, Li, M., additional, MacKrell, J., additional, Radeva, M., additional, Weiss, B., additional, Wiggins, K., additional, Alpers, C., additional, Hudkins, K., additional, Wietecha, T., additional, Robbin, M., additional, Umphrey, H., additional, Alexander, L., additional, Abts, C., additional, Belt, L., additional, Vita, J., additional, Hamburg, N., additional, Duess, M., additional, Levit, A., additional, Higgins, H., additional, Ke, S., additional, Mandaci, O., additional, Snell, C., additional, Gravley, J., additional, Behnken, S., additional, Mortensen, R., additional, Chertow, G., additional, Besarab, A., additional, Brayman, K., additional, Diener-West, M., additional, Harrison, D., additional, Inker, L., additional, Louis, T., additional, McClellan, W., additional, Rubin, J., additional, Kusek, J., additional, and Star, R., additional

Published
2022
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24. Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation

Author

Feldman, H., Dember, L., Farber, A., Kaufman, J., Stern, L., LeSage, P., Kivork, C., Soares, D., Malikova, M., Allon, M., Young, C., Taylor, M., Woodard, L., Mangadi, K., Roy-Chaudhury, P., Munda, R., Lee, T., Alloway, R., El-Khatib, M., Canaan, T., Pflum, A., Thieken, L., Campos-Naciff, B., Huber, T., Berceli, S., Jansen, M., McCaslin, G., Trahan, Y., Vazquez, M., Vongpatanasin, W., Davidson, I., Hwang, C., Lightfoot, T., Livingston, C., Valencia, A., Dolmatch, B., Fenves, A., Hawkins, N., Cheung, A., Kraiss, L., Kinikini, D., Treiman, G., Ihnat, D., Sarfati, M., Lavasani, I., Maloney, M., Schlotfeldt, L., Himmelfarb, J., Buchanan, C., Clark, C., Crawford, C., Hamlett, J., Kundzins, J., Manahan, L., Wise, J., Beck, G., Gassman, J., Greene, T., Imrey, P., Li, L., Alster, J., Li, M., MacKrell, J., Radeva, M., Weiss, B., Wiggins, K., Alpers, C., Hudkins, K., Wietecha, T., Robbin, M., Umphrey, H., Alexander, L., Abts, C., Belt, L., Vita, J., Hamburg, N., Duess, M., Levit, A., Higgins, H., Ke, S., Mandaci, O., Snell, C., Gravley, J., Behnken, S., Mortensen, R., Chertow, G., Besarab, A., Brayman, K., Diener-West, M., Harrison, D., Inker, L., Louis, T., McClellan, W., Rubin, J., Kusek, J., Star, R., Li, Yingnan, He, Yong, Falzon, Isabelle, Fairbourn, Brayden, Tingey, Spencer, Imrey, Peter B., Radeva, Milena K., Beck, Gerald J., Gassman, Jennifer J., Roy-Chaudhury, Prabir, Berceli, Scott A., Cheung, Alfred K., and Shiu, Yan-Ting

Published
2022
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25. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

Author

Hemnes, Anna R., Beck, Gerald J., Newman, John H., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Berman Rosenzweig, Erika, Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Erzurum, Serpil C., Frantz, Robert P., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Hill, Nicholas S., Horn, Evelyn M., Hu, Bo, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., Olman, Mitchell A., Rischard, Franz P., Systrom, David M., Tang, W.H. Wilson, Waxman, Aaron B., Xiao, Lei, Yuan, Jason X.-J., and Leopold, Jane A.

Published
2017
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26. Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery

Author

Alpers, Charles E., Imrey, Peter B., Hudkins, Kelly L., Wietecha, Tomasz A., Radeva, Milena, Allon, Michael, Cheung, Alfred K., Dember, Laura M., Roy-Chaudhury, Prabir, Shiu, Yan-Ting, Terry, Christi M., Farber, Alik, Beck, Gerald J., Feldman, Harold I., Kusek, John W., Himmelfarb, Jonathan, Dember, LM, Imrey, PB, Beck, GJ, Cheung, AK, Himmelfarb, J, Huber, TS, Kusek, JW, Roy-Chaudhury, P, Vazquez, MA, Alpers, CE, Robbin, ML, Vita, JA, Greene, T, Gassman, JJ, and Feldman, HI

Published
2017
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27. Supplemental Material, sj-pdf-1-ojs-10.1177_23259671211065447 - Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial

Author

Spindler, Kurt P., Imrey, Peter B., Yalcin, Sercan, Beck, Gerald J., Calbrese, Gary, Cox, Charles L., Fadale, Paul D., Farrow, Lutul, Fitch, Robert, Flanigan, David, Fleming, Braden C., Hulstyn, Michael J., Jones, Morgan H., Kaeding, Christopher, Katz, Jeffrey N., Kriz, Peter, Magnussen, Robert, McErlean, Ellen, Melgaard, Carrie, Owens, Brett D., Saluan, Paul, Strnad, Greg, Winalski, Carl S., and Wright, Rick

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental Material, sj-pdf-1-ojs-10.1177_23259671211065447 for Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial by BEAR-MOON Design Group, Kurt P. Spindler, Peter B. Imrey, Sercan Yalcin, Gerald J. Beck, Gary Calbrese, Charles L. Cox, Paul D. Fadale, Lutul Farrow, Robert Fitch, David Flanigan, Braden C. Fleming, Michael J. Hulstyn, Morgan H. Jones, Christopher Kaeding, Jeffrey N. Katz, Peter Kriz, Robert Magnussen, Ellen McErlean, Carrie Melgaard, Brett D. Owens, Paul Saluan, Greg Strnad, Carl S. Winalski and Rick Wright in Orthopaedic Journal of Sports Medicine

Published
2022
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28. Ultrasound-guided Percutaneous Cryoneurolysis to Treat Chronic Postamputation Phantom Limb Pain: A Multicenter Randomized Controlled Trial.

Author

Ilfeld, Brian M., Smith, Cameron R., Turan, Alparslan, Mariano, Edward R., Miller, Matthew E., Fisher, Rick L., Trescot, Andrea M., Cohen, Steven P., Eisenach, James C., Sessler, Daniel I., Prologo, J. David, Mascha, Edward J., Liu, Liu, Gabriel, Rodney A., Hayek, Salim M., Wadhwa, Anupama N., Beck, Gerald J., Abdullah, Baharin, Esa, Wael Ali Sakr, and Altinpulluk, Ece Yamak

Published
2023
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29. Arteriovenous Fistula Maturation, Functional Patency, and Intervention Rates

Author

Huber, Thomas S., primary, Berceli, Scott A., additional, Scali, Salvatore T., additional, Neal, Dan, additional, Anderson, Erik M., additional, Allon, Michael, additional, Cheung, Alfred K., additional, Dember, Laura M., additional, Himmelfarb, Jonathan, additional, Roy-Chaudhury, Prabir, additional, Vazquez, Miguel A., additional, Alpers, Charles E., additional, Robbin, Michelle L., additional, Imrey, Peter B., additional, Beck, Gerald J., additional, Farber, Alik M., additional, Kaufman, James S., additional, Kraiss, Larry W., additional, Vongpatanasin, Wanpen, additional, Kusek, John W., additional, and Feldman, Harold I., additional

Published
2021
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31. A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas

Author

Baron, John A., Barry, Elizabeth L., Mott, Leila A., Rees, Judy R., Sandler, Robert S., Snover, Dale C., Bostick, Roberd M., Ivanova, Anastasia, Cole, Bernard F., Ahnen, Dennis J., Beck, Gerald J., Bresalier, Robert S., Burke, Carol A., Church, Timothy R., Cruz-Correa, Marcia, Figueiredo, Jane C., Goodman, Michael, Kim, Adam S., Robertson, Douglas J., Rothstein, Richard, Shaukat, Aasma, Seabrook, March E., and Summers, Robert W.

Published
2015
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38. NEW DIALYSIS TECHNIQUES

Author

Kliger, Alan S, Chertow, Glenn M, Levin, Nathan W, Beck, Gerald J, Daugirdas, John T, Eggers, Paul W, Larive, Brett, Rocco, Michael V, and Greene, Tom

Published
2014

39. Effect of dipyridamole plus aspirin on hemodialysis graft patency

Author

Dixon, Bradley S., Beck, Gerald J., Vazquez, Miguel A., Greenberg, Arthur, Delmez, James A., Allon, Michael, Dember, Laura M., Himmelfarb, Jonathan, Gassman, Jennifer J., Greene, Tom, Radeva, Milena K., Davidson, Ingemar J., Ikizler, T. Alp., Braden, Gregory L., Fenves, Andrew Z ., Kaufman, James S., Cotton, James R., Jr., Martin, Kevin J., McNeil, James W., Rahman, Asif, Lawson, Jeffery H., Whiting, James W., Hu, Bo, Meyers, Catherine M., Kusek, John W., and Feldman, Harold I.

Subjects
Aspirin -- Evaluation, Aspirin -- Complications and side effects, Dipyridamole -- Evaluation, Dipyridamole -- Complications and side effects, Hemodialysis -- Health aspects, Stenosis -- Causes of, Stenosis -- Drug therapy, Drug therapy, Combination
Abstract

A study was conducted to determine the beneficial effects of administering dipyridamole for patients undergoing hemodialysis. Results revealed that treatment with dipyridamole plus aspirin had a positive effect and reduced the risk of stenosis while improving the duration of primary unassisted patency of new grafts.

Published
2009

40. Effect of Clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial

Author

Dember, Laura M., Beck, Gerald J., Allon, Michael, Delmez, James A., Dixon, Bradley S., Greenberg, Arthur, Himmelfarb, Jonathan, Vazquez, Miguel A., Gassman, Jennifer J., Greene, Tom, Radeva, Milena K., Braden, Gregory L., Ikizler, T. Alp, Rocco, Michael V., Davidson, Ingemar J., Kaufman, James S., Meyers, Catherine M., Kusek, John W., and Feldman, Harold I.

Subjects
Clopidogrel -- Evaluation, Blood clot -- Prevention, Thrombosis -- Prevention
Abstract

A study was conducted to establish the efficacy of clopidogrel in reducing early failure of hemodialysis fistulas. Results indicated that clopidogrel is helpful to reduce the frequency of early thrombosis of new arteriovenous fistulas but does not increase the proportion of fistulas for dialysis.

Published
2008

41. Body Mass Index and Mortality in CKD

Author

Madero, Magdalena, Sarnak, Mark J., Wang, Xuelei, Sceppa, Carmen Castaneda, Greene, Tom, Beck, Gerald J., Kusek, John W., Collins, Allan J., Levey, Andrew S., and Menon, Vandana

Published
2007
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42. A randomized trial of aspirin to prevent colorectal adenomas

Author

Baron, John A., Cole, Bernard F., Sandler, Robert S., Haile, Robert W., Ahnen, Dennis, Bresalier, Robert, McKeown-Eyssen, Gail, Summers, Robert W., Rothstein, Richard, Burke, Carol A., Snover, Dale C., Church, Timothy R., Allen, John I., Beach, Michael, Beck, Gerald J., Bond, John H., Byers, Tim, Greenberg, E. Robert, Mandel, Jack S., Marcon, Norman, Mott, Leila A., Pearson, Loretta, Saibil, Fred, and Stolk, Rosalind U. van

Subjects
Colorectal cancer -- Prevention, Aspirin -- Evaluation
Abstract

Low-doses of aspirin may prevent colorectal cancer from getting worse, according to a study of 1,121 patients who had recently been diagnosed with colorectal tumors. The progression of the cancer was slower in patients who took 81 milligrams of aspirin, compared to the patients who took 325 milligrams of aspirin or a placebo.

Published
2003

44. Effect of dialysis dose and membrane flux in maintenance hemodialysis

Author

Eknoyan, Garabed, Beck, Gerald J., Cheung, Alfred K., Daugirdas, John T., Greene, Tom, Kusek, John W., Allon, Michael, Bailey, James, Delmez, James A., Depner, Thomas A., Dwyer, Johanna T., Levey, Andrew S., Levin, Nathan W., Milford, Edgar, Ornt, Daniel B., Rocco, Michael V., Schulman, Gerald, Schwab, Steve J., Teehan, Brendan P., and Toto, Robert

Subjects
Hemodialysis -- Dosage and administration, Hemodialysis -- Methods, Chronic kidney failure -- Patient outcomes, Chronic kidney failure -- Care and treatment
Abstract

A higher than normal dialysis dose or a high flux membrane do not appear to benefit most dialysis patients, according to a study of 1,846 patients. However, some patients in the study appeared to benefit, so further research should be done to identify patients who might benefit from these changes. A high flux membrane removes larger particles from blood.

Published
2002

46. Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.

Author

Spindler, Kurt P., Imrey, Peter B., Yalcin, Sercan, Beck, Gerald J., Calbrese, Gary, Cox, Charles L., Fadale, Paul D., Farrow, Lutul, Fitch, Robert, Flanigan, David, Fleming, Braden C., Hulstyn, Michael J., Jones, Morgan H., Kaeding, Christopher, Katz, Jeffrey N., Kriz, Peter, Magnussen, Robert, McErlean, Ellen, Melgaard, Carrie, and Owens, Brett D.

Published
2022
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48. The effect of increased frequency of hemodialysis on serum cystatin C and β2-microglobulin concentrations: A secondary analysis of the frequent hemodialysis network (FHN) trial

Author

Huang, Shih-Han S, Kaysen, George A, Levin, Nathan W, Kliger, Alan S, Beck, Gerald J, Rocco, Michael V, Filler, Guido, and Lindsay, Robert M

Subjects
Pediatrics, hemodialysis, urea modeling, hemodialysis adequacy, cystatin C, beta 2-microglobulin
Abstract

INTRODUCTION: Small molecular weight toxin clearance is the main method of assessment of hemodialysis efficiency. Middle molecules including cystatin C (CysC) and Beta-2 microglobulin (β2-M) are understudied. We hypothesized that lowering of predialysis CysC and β2-M serum concentrations would be affected by switching to more frequent hemodialysis. METHODS: Predialysis CysC and β2-M serum concentrations were measured from serum samples of the Frequent Hemodialysis Network (FHN) Daily and Nocturnal Trials. The differences between predialysis concentrations at baseline (while on conventional thrice weekly dialysis) and those after 12-months of study (on more frequent dialysis) were compared separately by trial (Nocturnal, Daily). We tested the associations between predialysis serum CysC and β2-M concentrations and outcomes. FINDINGS: Forty-nine percent and 52% of the patients from the FHN Daily and Nocturnal Trials respectively were included in this ancillary study. Predialysis serum CysC concentrations remained unchanged after intensifying hemodialysis dose by either modality. There was significant lowering of the serum β2-M concentrations in the frequent Daily Trial hemodialysis group at 12 months in all patients and in patients without residual renal function at baseline (-3.8 ± 12.62 μg/mL, P = 0.004; -5.9 ± 12.99 μg/mL, P = 0.02, respectively). There were no significant differences between the baseline and the 12-months predialysis β2-M serum concentrations in the two control groups (Daily 3× and Nocturnal 3× groups). No association between the changes in the two biomarkers between baseline and 12-months and in changes in left ventricular mass, physical-health composite scores, hospitalization rate, and death were found. The numbers of hospitalizations and deaths were small. DISCUSSION: β2-M may be a better biomarker of dialysis dose than CysC. Reduction in the concentration of potentially toxic long-lived proteins of the size of β-2M is one potential long-term benefit of more intensive dialysis that may be explored.

Published
2019

50. Folic Acid for the Prevention of Colorectal Adenomas: A Randomized Clinical Trial

Author

Cole, Bernard F., Baron, John A., Sandler, Robert S., Haile, Robert W., Ahnen, Dennis J., Bresalier, Robert S., McKeown-Eyssen, Gail, Summers, Robert W., Rothstein, Richard I., Burke, Carol A., Snover, Dale C., Church, Timothy R., Allen, John I., Robertson, Douglas J., Beck, Gerald J., Bond, John H., Byers, Tim, Mandel, Jack S., Mott, Leila A., Pearson, Loretta H., Barry, Elizabeth L., Rees, Judy R., Marcon, Norman, Saibil, Fred, Ueland, Per Magne, and Greenberg, E. Robert

Published
2007

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