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6. Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament

Author

Masi, Gabriele, primary, Pisano, Simone, additional, Sesso, Gianluca, additional, Mazzullo, Cristina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Narzisi, Antonio, additional, Placini, Francesca, additional, Valente, Elena, additional, Viglione, Valentina, additional, and Milone, Annarita, additional

Published
2023
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12. Early Sensory Profile in Autism Spectrum Disorders Predicts Emotional and Behavioral Issues

Author

Fabbri-Destro, Maddalena, primary, Maugeri, Federica, additional, Ianni, Carolina, additional, Corsini, Sofia, additional, Di Stefano, Erica, additional, Scatigna, Stefano, additional, Crifaci, Giulia, additional, Bruzzi, Gianina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Pelagatti, Susanna, additional, Pecchini, Edoardo, additional, Zulli, Filippo, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Viglione, Valentina, additional, Barone, Rita, additional, Masi, Gabriele, additional, and Narzisi, Antonio, additional

Published
2022
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13. Internet Gaming Disorder in Children and Adolescents with Attention Deficit Hyperactivity Disorder

Author

Berloffa, Stefano, primary, Salvati, Andrea, additional, D’Acunto, Giulia, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Lenzi, Francesca, additional, Milone, Annarita, additional, Muratori, Pietro, additional, Pfanner, Chiara, additional, Ricci, Federica, additional, Ruglioni, Laura, additional, Tacchi, Annalisa, additional, Tessa, Chiara, additional, Villafranca, Arianna, additional, and Masi, Gabriele, additional

Published
2022
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14. Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: A Descriptive Study Using the Sensory Processing Measure-2 (SPM-2)

Author

Narzisi, Antonio, primary, Fabbri-Destro, Maddalena, additional, Crifaci, Giulia, additional, Scatigna, Stefano, additional, Maugeri, Federica, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Pecchini, Edoardo, additional, Pelagatti, Susanna, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Barone, Rita, additional, and Masi, Gabriele, additional

Published
2022
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15. Clinical Implications of DSM-IV Subtyping of Bipolar Disorders in Referred Children and Adolescents

Author

Masi, Gabriele, Perugi, Giulio, Millepiedi, Stefania, Mucci, Maria, Pari, Cinzia, Pfanner, Chiara, Berloffa, Stefano, and Toni, Cristina

Abstract

Objective: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. Method: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 [+ or -] 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). Results: Seventy-eight patients (35.9%) had BD I, 97 (44.7%) had BD II,and 42 (19.4%) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. Conclusions: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. (Contains 3 tables.)

Published
2007

16. Neurodevelopmental Disorders, Schizophrenia Spectrum Disorders and Catatonia: The "Iron Triangle" Rediscovered in a Case Report.

Author

Fantozzi, Pamela, Del Grande, Claudia, Berloffa, Stefano, Tolomei, Greta, Salluce, Carmen, Narzisi, Antonio, Salarpi, Gianluca, Capovani, Barbara, and Masi, Gabriele

Subjects
THERAPEUTIC use of lithium, DIAGNOSIS of schizophrenia, DIAGNOSIS of autism, SUBSTANCE abuse, ELECTROCONVULSIVE therapy, CATATONIA, CHILD psychopathology, MENTAL depression, CLASSIFICATION of mental disorders, EMOTION regulation, ANTIPSYCHOTIC agents, VALPROIC acid, GABAPENTIN, TRANQUILIZING drugs, SYMPTOMS, ADOLESCENCE
Abstract

Catatonia is a complex neuropsychiatric syndrome, occurring in the context of different psychiatric and neurodevelopmental disorders, in neurological and medical disorders, and after substance abuse or withdrawal. The relationship between Autism Spectrum Disorder (ASD), Schizophrenia Spectrum Disorders (SSDs) and catatonia has been previously discussed, with the three disorders interpreted as different manifestations of the same underlying brain disorder (the "Iron Triangle"). We discuss in this paper the diagnostic, clinical and therapeutic implications of this complex relationship in an adolescent with ASD, who presented an acute psychotic onset with catatonia, associated with mixed mood symptoms. Second-generation antipsychotics were used to manage psychotic, behavioral and affective symptoms, with worsening of the catatonic symptoms. In this clinical condition, antipsychotics may be useful at the lowest dosages, with increases only in the acute phases, especially when benzodiazepines are ineffective. Mood stabilizers with higher GABAergic effects (such as Valproate and Gabapentin) and Lithium salts may be more useful and well tolerated, given the frequent association of depressive and manic symptoms with mixed features. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability questionnaire–youth version (RIPoSt–Y)

Author

Sesso, Gianluca, primary, Milone, Annarita, additional, Drago, Flavia, additional, Viglione, Valentina, additional, Berloffa, Stefano, additional, Boldrini, Silvia, additional, Loriaux, Nina, additional, Valente, Elena, additional, Molesti, Agnese, additional, Placini, Francesca, additional, Montesanto, Anna Rita, additional, Pisano, Simone, additional, and Masi, Gabriele, additional

Published
2021
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21. Could You Give Me the Blue Brick? LEGO®-Based Therapy as a Social Development Program for Children with Autism Spectrum Disorder: A Systematic Review

Author

Narzisi, Antonio, primary, Sesso, Gianluca, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Villafranca, Arianna, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2021
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25. Reactivity, Intensity, Polarity and Stability Questionnaire--Youth Version

Author

Sesso, Gianluca, primary, Milone, Annarita, additional, Drago, Flavia, additional, Viglione, Valentina, additional, Berloffa, Stefano, additional, Boldrini, Silvia, additional, Loriaux, Nina, additional, Valente, Elena, additional, Molesti, Agnese, additional, Placini, Francesca, additional, Montesanto, Anna Rita, additional, Pisano, Simone, additional, and Masi, Gabriele, additional

Published
2021
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26. Autism Spectrum Disorder and Disruptive Behavior Disorders Comorbidities Delineate Clinical Phenotypes in Attention-Deficit Hyperactivity Disorder: Novel Insights from the Assessment of Psychopathological and Neuropsychological Profiles

Author

Sesso, Gianluca, primary, Cristofani, Chiara, additional, Berloffa, Stefano, additional, Cristofani, Paola, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Narzisi, Antonio, additional, Pfanner, Chiara, additional, Ricci, Federica, additional, Tacchi, Annalisa, additional, Valente, Elena, additional, Viglione, Valentina, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2020
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29. A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode

Author

Masi, Gabriele, primary, Berloffa, Stefano, additional, Muratori, Pietro, additional, Mucci, Maria, additional, Viglione, Valentina, additional, Villafranca, Arianna, additional, Inguaggiato, Emanuela, additional, Levantini, Valentina, additional, Placini, Francesca, additional, Pfanner, Chiara, additional, D’Acunto, Giulia, additional, Lenzi, Francesca, additional, Liboni, Francesca, additional, and Milone, Annarita, additional

Published
2020
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31. Internet addiction disorder in referred adolescents: a clinical study on comorbidity.

Author

Masi, Gabriele, Berloffa, Stefano, Muratori, Pietro, Paciello, Marinella, Rossi, Martina, and Milone, Annarita

Subjects
*SOCIAL problems, *INTERNET addiction in adolescence, *CHILD Behavior Checklist, *DESCRIPTIVE statistics, *ANXIETY, *CLUSTER analysis (Statistics), *COMORBIDITY, *LONGITUDINAL method
Abstract

It is currently debated whether specific psychiatric disorders or Internalizing versus Externalizing psychopathological dimensions are associated to Internet Addiction Disorder (IAD). We explored this issue in youth with and without IAD referred to a third-level Department of Adolescent Psychiatry during a 12-month period. All the 101 consecutively referred adolescents were assessed using categorical (Schedule for Affective Disorders and Schizophrenia for School- Age Children-K-SADS) and dimensional (Child Behavior Checklist-CBCL) measures of psychopathology, and two measures for addictive behaviors, Internet Addiction Test (IAT) (used as screening for detecting IAD patients) and Use, Abuse, Dependence on the Internet (UADI) inventory. According to an IAT cutoff score of 50, 39 patients (38.6%) presented IAD. The IAD and the no IAD groups did not differ according to age and gender. Most of the IAD patients (92.3%) endorsed multiple addictions. The IAD group had higher scores in all the UADI dimensions, except for Impact of Life. All the IAD patients endorsed psychiatric diagnoses, but only Autism Spectrum Disorders were more represented in the IAD group. According to the CBCL, patients with IAD had more social problems and anxiety symptoms. However, clusters analysis with the t-scores of the CBCL scales of Internalizing and Externalizing domains showed no differences in IAT and UADI scores among clusters. The small sample size and a selection bias (referrals for severe symptomatology) limit the generalization of the findings. Comorbidity should be systematically assessed in IAD adolescents, with categorical and dimensional measures, as it may guide personalized treatments. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Could You Give Me the Blue Brick? LEGO ® -Based Therapy as a Social Development Program for Children with Autism Spectrum Disorder: A Systematic Review.

Author

Narzisi, Antonio, Sesso, Gianluca, Berloffa, Stefano, Fantozzi, Pamela, Muccio, Rosy, Valente, Elena, Viglione, Valentina, Villafranca, Arianna, Milone, Annarita, and Masi, Gabriele

Subjects
CHILDREN with autism spectrum disorders, SOCIAL development, SOCIAL services, CHILD development, SOCIAL skills
Abstract

LEGO®-based therapy is a social skills development program aimed at children with autism spectrum disorder (ASD). A systematic review of the literature was conducted using PRISMA guidelines. PubMed, Scopus and Web of Science bibliographic databases were searched from their date of inception to August 2020. The review included 19 studies. Studies were classified according to experimental designs (e.g., Randomized Control Trial, Non-Randomized Studies of Interventions and case report and series) and a narrative synthesis of each was provided, along with a critical discussion of the strengths and weaknesses of the available literature on the topic. Although LEGO®-based therapy appears a promising treatment for social interaction in ASD, the findings of LEGO®-based therapy studies should be interpreted and generalized with caution, due to the low quality of the studies and the small sample sizes. [ABSTRACT FROM AUTHOR]

Published
2021
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42. A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability questionnaire–youth version (RIPoSt–Y)

Author

Elena Valente, Flavia Drago, Stefano Berloffa, Francesca Placini, Anna Rita Montesanto, Gianluca Sesso, Nina Loriaux, Agnese Molesti, Gabriele Masi, Simone Pisano, Annarita Milone, Valentina Viglione, Silvia Boldrini, Sesso, Gianluca, Milone, Annarita, Drago, Flavia, Viglione, Valentina, Berloffa, Stefano, Boldrini, Silvia, Loriaux, Nina, Valente, Elena, Molesti, Agnese, Placini, Francesca, Montesanto, Anna Rita, Pisano, Simone, and Masi, Gabriele

Subjects
Psychometrics, Adolescent, Bipolar disorder, Emotions, Concurrent validity, Reproducibility of Result, Emotional dysregulation, CBCL, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, medicine, Humans, ADHD, Surveys and Questionnaire, Reactivity (psychology), Emotion, Schools, Questionnaire, Reproducibility of Results, Construct validity, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Convergent validity, Self Report, Psychology, Construct (philosophy), Psychometric, 030217 neurology & neurosurgery, Human, Clinical psychology
Abstract

Background The failure to regulate emotions, namely emotional dysregulation (ED), is a relevant construct in adolescent psychiatry, in terms of prognostic and developmental implications. We developed and validated a novel self-report questionnaire for the assessment of ED, the RIPoSt-Y, both in clinical and non-clinical samples. Methods Items selection and subscales construction were conducted on healthy controls (n=374), while test-retest reliability was evaluated in a subsample (n=72); internal consistency was examined both in the control group and in two clinical samples, respectively including patients with Bipolar Spectrum Disorders (BSD; n=44) and ADHD (n=34). Construct, concurrent and convergent validity were also assessed. Results Thirty-one items were finally retained, and three subscales were identified (Affective Instability, Emotional Reactivity, Interpersonal Sensitivity). Test-retest was significant for each subscale with moderate-to-good correlations, and internal consistency showed good-to-excellent coefficients. Construct validity was supported by significant differences between patients and controls and gender-related differences. Concurrent validity was confirmed through significant associations with two subscales of the CHT-Q, while convergent validity proved to be significant with the CBCL/YSR dysregulation-profile. Cut-offs were also computed to discriminate clinically significant scores of ED. Limitations The use of a school-based survey to recruit controls could have biased our results; gender distributions between clinical and non-clinical samples were significantly different. Conclusions Our novel questionnaire proved to be a valid and reliable tool able to assess the presence of ED in youths and to characterize this fundamental construct in its multidimensional facets.

Published
2021

43. Lithium treatment in bipolar adolescents: a follow-up naturalistic study

Author

Stefano Berloffa, Simone Pisano, Annarita Milone, Valentina Viglione, Gabriele Masi, Gabriella Bruni, Maria Mucci, Giulia Scrinzi, Masi, Gabriele, Milone, Annarita, Scrinzi, Giulia, Mucci, Maria, Viglione, Valentina, Bruni, Gabriella, Berloffa, Stefano, and Pisano, Simone

Subjects
safety, medicine.medical_specialty, Neuropsychiatric Disease and Treatment, Lithium (medication), Sedation, QT interval, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, White blood cell, Internal medicine, medicine, 0501 psychology and cognitive sciences, adolescents, Bipolar disorder, Original Research, bipolar disorder, business.industry, 05 social sciences, Thyroid, medicine.disease, 3. Good health, 030227 psychiatry, medicine.anatomical_structure, lithium, adolescent, Long term data, medicine.symptom, business, 050104 developmental & child psychology, Hormone, medicine.drug
Abstract

Gabriele Masi,1 Annarita Milone,1 Giulia Scrinzi,2 Maria Mucci,1 Valentina Viglione,1 Gabriella Bruni,1 Stefano Berloffa,1 Simone Pisano3 1IRCCS Stella Maris Foundation, Developmental Psychiatry and Psychopharmacology Unit, Pisa, Italy; 2Child Neuropsychiatry Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy; 3Clinic of Child and Adolescent Neuropsychiatry, Department of Medicine and Surgery, University of Salerno, Salerno, Italy Background: Although lithium is currently approved for the treatment of bipolar disorders in youth, long term data, are still scant. The aim of this study was to describe the safety and efficacy of lithium in referred bipolar adolescents, who were followed up at the 4th (T1) and 8th (T2) month of treatment.Methods: The design was naturalistic and retrospective, based on a clinical database, including 30 patients (18 males, mean age 14.2±2.1 years).Results: Mean blood level of lithium was 0.69±0.20 mEq/L at T1 and 0.70±0.18 mEq/L at T2. Both Clinical Global Impression-Severity (CGI-S) and Children Global Assessment Scale (C-GAS) scores improved from baseline (CGI-S 5.7±0.5, C-GAS 35.1±3.7) to T1 (CGI-S 4.2±0.70, C-GAS 46.4±6.5; P

Published
2018

44. Social Skills Interventions for Adolescents with Level 1 Autism Spectrum Disorder: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.

Author

Narzisi A, Sesso G, Fabbri-Destro M, Berloffa S, Fantozzi P, Muccio R, Bruzzi G, Scatigna S, Valente E, Viglione V, Milone A, Cortese S, and Masi G

Abstract

Objective: Evidence on the efficacy of social skills training for adolescents with Level 1 Autism Spectrum Disorder (ASD) is unclear., Method: We searched Pubmed, Scopus, and Web of Science until July 27th, 2023, for randomized controlled trials (RCTs) of social skills training for pre-adolescents and adolescents (aged 9-18) with Level 1 ASD. We then pooled data on efficacy from individual RCTs by conducting multivariate mixed-effects meta-analyses in R. We estimated possible bias in the retained RCTs using the RoB2 tool., Results: We retained 36 RCTs (encompassing 2796 participants), including 18 RCTs comparing an experimental treatment to a waiting list, and 18 RCTs comparing it to standard care/control treatment. Meta-analyses showed that experimental treatments were significantly more efficacious than waiting list or standard care/ control treatments in improving social skills (SMD = 0.3745; 95%CI = [0.2396; 0.5093]), as well as reducing behavioral symptoms (0.3154;0.1783, 0.4525) and anxious/depressive symptoms (0.2780; 0.0432, 0.5128). However, for some outcomes there was significant heterogeneity across studies and evidence of publication bias. Subgroup analyses and meta-regressions did not identify any specific clinical or demographic factors as significant predictors of outcome. The most common risk of bias across studies was related to deviations from intended interventions and measurement of the outcomes., Conclusions: At the group level, social skills training for adolescents with Level 1 ASD is efficacious, with small-to-moderate effect size. Future research should focus on personalized medicine approaches, aimed at tailoring interventions to specific characteristics of adolescents with Level 1 ASD., Competing Interests: Competing interests: G.M. was on advisory boards for Angelini, received grants from Lundbeck and Humana, and was a speaker for Angelini, Neuraxpharm, and Otsuka. The other authors had no conflict of interest to disclose., (© 2024 Giovanni Fioriti Editore s.r.l.)

Published
2024
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