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13. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

Author

Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Fetal Membranes, Premature Rupture, obstetric intervention, [SDV]Life Sciences [q-bio], Gestational Age, antenatal management, Cohort Studies, Pregnancy, Escherichia coli, Humans, Prospective Studies, latency, amoxicillin, neurodevelopment, macrolides, prematurity, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Infant, prophylactic antibiotics, Antibiotic Prophylaxis, Anti-Bacterial Agents, perinatal outcome, cephalosporins, Premature Birth, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neonatal Sepsis, Infant, Premature
Abstract

To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.

Published
2022

14. Gestational anaemia and severe acute maternal morbidity: a population‐based study*

Author

Guignard, J., Deneux‐Tharaux, C., Seco, A., Beucher, G., Kayem, G., Bonnet, M.‐P., Langer, B, Dupont, C, Rudigoz, R.‐C, Venditelli, F, Rozenberg, P, Carbillon, L, Azria, E, Baunot, N, Crenn‐Hebert, C, Fresson, J, Mignon, A, Bouvier‐Colle, M.‐H, Chantry, A, Chiesa‐Dubruille, C, European Synchrotron Radiation Facility (ESRF), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Service de Gynécologie-Obstétrique, Hôpital Louis-Mourier, AP-HP, 92701 Colombes, France., Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe de recherche clinique Centre Expert en Endométriose (GRC 6 - C3E), and Sorbonne Université (SU)

Subjects
Adult, medicine.medical_specialty, Adolescent, Maternal morbidity, macromolecular substances, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Logistic regression, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030202 anesthesiology, Epidemiology, Prevalence, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, business.industry, Obstetrics, Incidence, Incidence (epidemiology), Postpartum Period, Pregnancy Complications, Hematologic, Confounding, Anemia, medicine.disease, 3. Good health, Causality, Pregnancy Complications, Maternal Mortality, Anesthesiology and Pain Medicine, Case-Control Studies, Gestation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, business
Abstract

Anaemia is frequently diagnosed during pregnancy. However, there are few data regarding its incidence, and the association with severe maternal morbidity remains uncertain and potentially biased in high-resource countries. The purpose of this study was to explore the association between gestational anaemia and severe acute maternal morbidity during and after delivery. We performed a cohort-nested case-control analysis from the epidemiology of severe maternal mortality (EPIMOMS) prospective study conducted in six French regions (2012-2013, n = 182,309 deliveries). There were 1669 women with severe acute maternal morbidity during or after delivery, according to a standardised definition obtained by expert consensus. The control group were randomly selected among women without severe morbidity who delivered in the same health centres (n = 3234). We studied the association between gestational anaemia and severe acute maternal morbidity during or after delivery overall, by cause, and by mode of delivery, using multivariable logistic regression and multiple imputation. Gestational anaemia was significantly more frequent in women with severe acute maternal morbidity (25.3%) than in controls (16.3%), p < 0.001, and mostly mild in both groups. After adjustment for confounders, women with gestational anaemia were at increased risk of overall severe acute maternal morbidity during and after delivery (adjusted OR (95%CI) 1.8 (1.5-2.1)). This association was also found for severe postpartum haemorrhage (adjusted OR (95%CI) 1.7 (1.5-2.0)), even after omitting the transfusion criterion (adjusted OR (95%CI) 1.9 (1.6-2.3)), and for severe acute maternal morbidity secondary to causes other than haemorrhage or pregnancy-related hypertensive disorders (adjusted OR (95%CI) 2.7 (1.9-4.0)). These results highlight the importance of optimising the diagnosis and management of anaemia during pregnancy.

Published
2020

15. Cohort Profile: the Etude Epidémiologique sur les Petits Ages Gestationnels-2 (EPIPAGE-2) preterm birth cohort

Author

Lorthe, Elsa, Benhammou, Valérie, Marchand-Martin, Laetitia, Pierrat, Véronique, Lebeaux, Cécile, Durox, Mélanie, Goffinet, François, Kaminski, Monique, Ancel, Pierre-Yves, Astruc, D, Kuhn, P, Langer, B, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly-Pedespan, L, Rebola, M, Costedoat, M, Leguen, A, Martin, C, Lecomte, B, Lemery, D, Vendittelli, F, Rochette, E, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Rots, D, Burguet, A, Couvreur, S, Gouyon, J, Sagot, P, Colas, N, Franzin, A, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, R, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Aoustin, E, Bednarek, N, Morville, P, Verrière, V, THIRIEZ, G, Balamou, C, Ratajczak, C, Marpeau, L, Marret, S, Barbier, C, Mestre, N, Kayem, G, Durrmeyer, X, Granier, M, Lapillonne, A, Ayoubi, M, Baud, O, Carbonne, B, Foix L’Hélias, L, Jarreau, P, Mitanchez, D, Boileau, P, Duffaut, C, Cornu, L, Moras, R, Salomon, D, Medjahed, S, Ahmed, K, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Poujol, M, Bédu, A, Mons, F, Bahans, C, Binet, M, Fresson, J, Hascoët, J, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Arnaud, C, Vayssière, C, Baron, M, Charkaluk, M, Subtil, D, Truffert, P, Akowanou, S, Roche, D, Thibaut, M, D’Ercole, C, Gire, C, Simeoni, U, Bongain, A, DESCHAMPS, M, Zahed, M, Branger, B, Rozé, J, Winer, N, Gascoin, G, Sentilhes, L, Rouger, V, Dupont, C, Martin, H, Gondry, J, Krim, G, Baby, B, Popov, I, Debeir, M, Claris, O, Picaud, J, Rubio-Gurung, S, Cans, C, Ego, A, Debillon, T, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, J, Coliné, E, Cabrera, C, Favre, A, Joly, N, Stouvenel, A, Châlons, S, Pignol, J, Laurence, P, Lochelongue, V, Robillard, P, Samperiz, S, Ramful, D, Asadullah, H, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Delormel, V, Esmiol, S, Fériaud, M, Foix-L’Hélias, L, Khemache, K, Khoshnood, B, Onestas, L, Quere, M, Rousseau, J, Rtimi, A, Saurel-Cubizolles, M, Tran, D, Sylla, D, Vasante-Annamale, L, Zeitlin, J, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), CHU Estaing [Clermont-Ferrand], and CHU Clermont-Ferrand

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

18. Le diabète gestationnel: Référentiel élaboré par le Collège national des gynécologues et obstétriciens français (CNGOF) et par la Société francophone du diabète (SFD) – 2010

Author

Vambergu, Anne, Lepercq, J., Vayssiere, C., Boulot, P., Burdet, I., Criballet, G., Fau, C., Grandjean, H., Simeoni, U., Vambergue, A., Beucher, G., Burguet, A., Cosson, E., Deruelle, P., Galtier, F., Guedj, A.-M., Guyard-Boileau, B., Hieronimus, S., Jacqueminet, S., Jannot-Lamotte, M.-F., Kerlan, V., Laloi-Michelin, M., Le meaux, J.-P., Mitanchez, D., Thiebaugeorges, O., Verier-Mine, O., and Virally, M.

Published
2010
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24. Clinical profiles of placenta accreta spectrum: the PACCRETA population‐based study

Author

Kayem, G, primary, Seco, A, additional, Beucher, G, additional, Dupont, C, additional, Branger, B, additional, Crenn Hebert, C, additional, Huissoud, C, additional, Fresson, J, additional, Winer, N, additional, Langer, B, additional, Rozenberg, P, additional, Morel, O, additional, Bonnet, MP, additional, Perrotin, F, additional, Azria, E, additional, Carbillon, L, additional, Chiesa, C, additional, Raynal, P, additional, Rudigoz, RC, additional, Dreyfus, M, additional, Vendittelli, F, additional, Patrier, S, additional, Deneux‐Tharaux, C, additional, and Sentilhes, L, additional

Published
2021
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26. Liste des collaborateurs

Author

Almange, C., primary, Andrès, P., additional, Arcangeli-Belgy, M.-T., additional, Artus, M., additional, Assari, F., additional, Bacq, Y., additional, Bader, G., additional, Balouet, P., additional, Baraille, A., additional, Bardin-Bedu, C., additional, Beillat, T., additional, Benoist, G., additional, Beucher, G., additional, Blanchère, J.-P., additional, Blot, P., additional, Boog, G., additional, Boulogne, A.-I., additional, Brasseur, G., additional, Buzenet, C., additional, Cabrol, D., additional, Carbonne, B., additional, Carbonneaux, S., additional, Carles, G., additional, Carluer, L., additional, Chabrolle, J.-P., additional, Coffin, C., additional, Cournot, M.-P., additional, Cuvelier, A., additional, d'Ercole, C., additional, Dallay, D., additional, Dao, T., additional, Dayan, J., additional, de Guerke, L., additional, Dejean, A., additional, Delcroix, M., additional, Deschamps, A., additional, Desprats, R., additional, Diguet, A., additional, Dompmartin, A., additional, Doyen, C., additional, Dran, C., additional, Dreyfus, M., additional, Dupuis, O., additional, Durier, M., additional, Elefant, E., additional, Evain-Brion, D., additional, Faury, M.-N., additional, Forgeard, C., additional, Fournet, P., additional, Fournier, T., additional, Gabriel, R., additional, Galley-Raulin, F., additional, Galliot, L., additional, Gaucherand, P., additional, Giami, I., additional, Goffinet, F., additional, Golfier, F., additional, Gomez, C., additional, Gondry, J., additional, Gouyon, J.-B., additional, Grossetti, E., additional, Grout, M.-A., additional, Grynberg, M., additional, Guillaume, S., additional, Harvey, T., additional, Hebert, A., additional, Hillion, K., additional, Himily, V., additional, Houet-Zuccalli, T., additional, Houssin, I., additional, Kakol, M., additional, Langer, B., additional, Lansac, J., additional, Lanta, S., additional, Lavaud, M., additional, Le Querrec, A., additional, Lecointe-Jolly, V., additional, Lejeune, V., additional, Lemery, D., additional, Lepercq, J., additional, Leroy, S., additional, Lestang, I., additional, Longépé, J., additional, Lo Presti, J.-P., additional, Mahieu-Caputo, D., additional, Maillet, R., additional, Malassiné, A., additional, Mandelbrot, L., additional, Marpeau, L., additional, Marpeau-Delignière, P., additional, Marret, S., additional, Martin, S., additional, Massardier, J., additional, Mercier, C., additional, Moreau, Y., additional, Morin, C., additional, Muir, J.-F., additional, Nguyen, F., additional, Nivot-Roman, E., additional, Nizard, J., additional, Oury, J.-F., additional, Pajot-Pharose, E., additional, Parant, O., additional, Paris, F., additional, Polzin, K., additional, Provost, D., additional, Radi, S., additional, Renner, J.-P., additional, Reman, O., additional, Revaux, A., additional, Ricbourg, A., additional, Riethmuller, D., additional, Rivière, M., additional, Roman, H., additional, Rotten, D., additional, Rozenberg, P., additional, Schaal, J.-P., additional, Schnitzler, K., additional, Sentilhes, L., additional, Sergent, F., additional, Siegler, L., additional, Simon, A., additional, Simon-Toulza, C., additional, Sutter-Dallay, A.-L., additional, Szymansky, N., additional, Teurnier, F., additional, Trichot, C., additional, Tsatsaris, V., additional, Vallée, M.-M., additional, Vauzelle, C., additional, Venditelli, F., additional, Vercoustre, L., additional, Vérot, C., additional, Verspyck, E., additional, Viader, F., additional, Winer, N., additional, and Zanardi, M., additional

Published
2010
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32. Rupture prématurée des membranes avant terme : recommandations pour la pratique clinique du CNGOF — Texte court

Author

Schmitz, T., primary, Sentilhes, L., additional, Lorthe, E., additional, Gallot, D., additional, Madar, H., additional, Doret-Dion, M., additional, Beucher, G., additional, Charlier, C., additional, Cazanave, C., additional, Delorme, P., additional, Garabedian, C., additional, Azria, É., additional, Tessier, V., additional, Senat, M.-V., additional, and Kayem, G., additional

Published
2018
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35. Neonatal Outcomes for Women at Risk of Preterm Delivery Given Half Dose Versus Full Dose of Antenatal Betamethasone: A Randomized, Multicenter, Double-blind, Placebo-controlled, Noninferiority Trial

Author

Schmitz, T., Doret-Dion, M., Sentilhes, L., Parant, O., Claris, O., Renesme, L., Abbal, J., Girault, A., Torchin, H., Houllier, M., Le Saché, N., Vivanti, A.J., De Luca, D., Winer, N., Flamant, C., Thuillier, C., Boileau, P., Blanc, J., Brevaut, V., Bouet, P.E., Gascoin, G., Beucher, G., Datin-Dorriere, V., Bounan, S., Bolot, P., Poncelet, C., Alberti, C., Ursino, M., Aupiais, C., and Baud, O.

Abstract

(Lancet.2022;400:592–604)Antenatal corticosteroids are recommended worldwide to help premature fetus lung maturity. However, the current recommended dose may be too high, based on some neurological, mental, and behavioral side effects. This study compared a half-dose (12 mg) of antenatal betamethasone to the typical full dose (24 mg) to determine if a half-dose can be as effective as a full dose, as well as to ultimately determine if a half-dose should be recommended in order to lessen side effects.

Published
2023
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36. Induction of Labour Versus Expectant Management for Large-for-Date Fetuses: A Randomized-Controlled Trial

Author

Boulvain, M., primary, Senat, M.V., additional, Perrotin, F., additional, Winer, N., additional, Beucher, G., additional, Subtil, D., additional, Bretelle, F., additional, Azria, E., additional, Hejaiej, D., additional, Vendittelli, F., additional, Capelle, M., additional, Langer, B., additional, Matis, R., additional, Connan, L., additional, Gillard, P., additional, Kirkpatrick, C., additional, Ceysens, G., additional, Faron, G., additional, Irion, O., additional, and Rozenberg, P., additional

Published
2016
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37. Pregnancy loss: French clinical practice guidelines

Author

Huchon, C., primary, Deffieux, X., additional, Beucher, G., additional, Capmas, P., additional, Carcopino, X., additional, Costedoat-Chalumeau, N., additional, Delabaere, A., additional, Gallot, V., additional, Iraola, E., additional, Lavoue, V., additional, Legendre, G., additional, Lejeune-Saada, V., additional, Leveque, J., additional, Nedellec, S., additional, Nizard, J., additional, Quibel, T., additional, Subtil, D., additional, Vialard, F., additional, and Lemery, D., additional

Published
2016
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38. Overview and expert assessment of off-label use of misoprostol in obstetrics and gynaecology: review and report by the Collège national des gynécologues obstétriciens français

Author

Marret, H., primary, Simon, E., additional, Beucher, G., additional, Dreyfus, M., additional, Gaudineau, A., additional, Vayssière, C., additional, Lesavre, M., additional, Pluchon, M., additional, Winer, N., additional, Fernandez, H., additional, Aubert, J., additional, Bejan-Angoulvant, T., additional, Jonville-Bera, A.P., additional, Clouqueur, E., additional, Houfflin-Debarge, V., additional, Garrigue, A., additional, and Pierre, F., additional

Published
2015
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42. Standardisation de la terminologie des pertes de grossesse : consensus d’experts du Collège national des gynécologues et obstétriciens français (CNGOF)

Author

Delabaere, A., primary, Huchon, C., additional, Lavoue, V., additional, Lejeune, V., additional, Iraola, E., additional, Nedellec, S., additional, Gallot, V., additional, Capmas, P., additional, Beucher, G., additional, Subtil, D., additional, Carcopino, X., additional, Vialard, F., additional, Nizard, J., additional, Quibel, T., additional, Costedoat-Chalumeau, N., additional, Legendre, G., additional, Venditelli, F., additional, Rozenberg, P., additional, Lemery, D., additional, and Deffieux, X., additional

Published
2014
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43. Épidémiologie des pertes de grossesse

Author

Delabaere, A., primary, Huchon, C., additional, Deffieux, X., additional, Beucher, G., additional, Gallot, V., additional, Nedellec, S., additional, Vialard, F., additional, Carcopino, X., additional, Quibel, T., additional, Subtil, D., additional, Barasinski, C., additional, Gallot, D., additional, Vendittelli, F., additional, Laurichesse-Delmas, H., additional, and Lémery, D., additional

Published
2014
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45. Méthodologie des recommandations pour la pratique clinique concernant la prise en charge des pertes de grossesse

Author

Deffieux, X., primary, Huchon, C., additional, Delabaere, A., additional, Lavoue, V., additional, Nedellec, S., additional, Gallot, V., additional, Capmas, P., additional, Beucher, G., additional, Carcopino, X., additional, Vialard, F., additional, Nizard, J., additional, Quibel, T., additional, Costedoat-Chalumeau, N., additional, Legendre, G., additional, and Lemery, D., additional

Published
2014
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50. État des lieux et expertise de l’usage hors AMM du misoprostol en gynécologie-obstétrique : travail du CNGOF (texte court)

Author

Marret, H., primary, Simon, E., additional, Beucher, G., additional, Dreyfus, M., additional, Gaudineau, A., additional, Vayssière, C., additional, Lesavre, M., additional, Pluchon, M., additional, Winer, N., additional, Fernandez, H., additional, Aubert, J., additional, Bejan-Angoulvant, T., additional, Jonville-Bera, A.-P., additional, Clouqueur, É., additional, Houfflin-Debarge, V., additional, Garrigue, A., additional, and Pierre, F., additional

Published
2014
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