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3. Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Author

McGlinchey, Aidan, Sinioja, Tim, Lamichhane, Santosh, Sen, Partho, Bodin, Johanna, Siljander, Heli, Dickens, Alex M., Geng, Dawei, Carlsson, Cecilia, Duberg, Daniel, Ilonen, Jorma, Virtanen, Suvi M., Dirven, Hubert, Berntsen, Hanne Friis, Zimmer, Karin, Nygaard, Unni C., Orešič, Matej, Knip, Mikael, and Hyötyläinen, Tuulia

Published
2020
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8. Matproduksjon, mattrygghet og miljø - innspill om kunnskapsbehov til gjennomføringen av det grønne skiftet - Uttalelse fra hovedkomiteen i Vitenskapskomiteen for mat og miljø (VKM)

Author

Alexander, Jan, Aasmo-Finne, Merethe, Agdestein, Angelika, Bodin, Johanna Eva, Bruzell, Ellen Merete, Elvevoll, Edel O., Hemre, Gro Ingunn, Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Knutsen, Helle Katrine, Krogdahl, Åshild, Mathisen, Gro Haarklou, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Vandvik, Vigdis, Velle, Gaute, and Wasteson, Yngvild

Abstract

Source at https://vkm.no/

Published
2022

9. Assessment of genetically modified Soybean MON 87705 × MON 87708 × MON 89788 and sub-combinations, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2015-126) - Scientific Opinion of the Panel on genetically modified organisms of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Bodin, Johanna, Duale, Nur, Jevnaker, Anne-Marthe Ganes, Sanden, Monica, Sipinen, Ville Erling, Thorstensen, Tage, and Vikse, Rose

Published
2022

11. Food and chemical substances relevant for monitoring. Report from the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Svendsen, Camilla, Amlund, Heidi, Carlsen, Monica Hauger, Eriksen, Gunnar Sundstøl, Husøy, Trine, Lillegaard, Inger Therese Laugsand, Mathisen, Gro Haarklou, Medin, Anine Christine, Ørnsrud, Robin, Agdestein, Angelika, Bergh, Øivind, Bodin, Johanna, Bruzell, Ellen, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merethe, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Taran, Steffensen, Inger-Lise Karin, Strand, Tor A., Velle, Gaute, Hemre, Gro Ingunn, Vandvik, Vigdis, and Alexander, Jan

Abstract

Source at https://vkm.no/ At request from the Norwegian Food Safety Authority (NFSA), VKM has identified food groups and food items consumed by the Norwegian population that are relevant for monitoring regarding content of one or more undesirable chemical substances (Figure 1). Undesirable chemical substances were defined as chemical substances in food that may constitute a potential health risk. VKM has created a knowledge base (an Excel file) as a tool for planning and prioritising monitoring of foods and undesirable chemical substances. The substance groups included in the knowledge base are flavourings, food additives, metals and metalloids, natural toxins, persistent organic pollutants, process-induced contaminants, substances in food contact materials, substances in food supplements, and trace elements. More than 40 different substances were included.

Published
2022

13. Assessment of genetically modified maize DP4114 x MON810 x MIR604 x NK603 and sub-combinations, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2018-150) - Scientific Opinion of the Panel on genetically modified organisms of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Duale, Nur, Jevnaker, Anne-Marthe Ganes, Sanden, Monica, Sipinen, Ville Erling, Thorstensen, Tage, and Vikse, Rose

Published
2022

15. Benefit and risk assessment of fish in the Norwegian diet - Scientific Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Andersen, Lene Frost, Berstad, Paula, Bukhvalova, Barbara Alexandra, Carlsen, Monica Hauger, Dahl, Lisbeth Jane, Goksøyr, Anders, Jakobsen, Lea Sletting, Knutsen, Helle Katrine, Kvestad, Ingrid, Lillegaard, Inger Therese Laugsand, Mangschou, Bente, Meyer, Haakon Eduard, Parr, Christine Louise, Rakkestad, Kirsten Eline, Rasinger, Josef, Sengupta, Sayantan, Skeie, Guri, Starrfelt, Jostein, Ulven, Stine Marie, Agdestein, Angelika, Bodin, Johanna Eva, Bruzell, Ellen Merete, Elvevoll, Edel O., Hemre, Gro Ingunn, Hessen, Dag Olav, Husøy, Trine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Skjerdal, Olaug Taran, Steffensen, Inger-Lise, Strand, Tor Arne, Vandvik, Vigdis, Velle, Gaute, Wasteson, Yngvild, and Alexander, Jan

Subjects
Nevroutviklingsforstyrrelser, Allergy, Hjerte-karfysiologi / kardiovaskulærfysiologi, Forurensning, Heart diseases, Kardiovaskulære sykdommer, PFAS, Immunology, Metyl kvikksølv, Hjertesykdommer, Methyl mercury, Beinhelse, Cardiovascular Physiology, Dioxins, Systematic review and meta analysis, Bone health, Antropometri, Allergi, PCDF/PCDD dioxins, Koronar hjertesykdom, Dioksiner, Omega-3 fatty acids, Coronary Heart Disease, Vitamin D, Mortality, Dødelighet, Biokjemi: 476 [VDP], Mild kognitiv svikt, PCD PCDD dioksiner, Fruktbarhet, Anthropometry, Biochemistry: 476 [VDP], Diabetes, Neurodevelopmental disorders, Mild cognitive impairment, Nutrients, Pollution, Kognitiv funksjon, Fertility, Cardiovascular Diseases, Omega-3 fettsyrer, Immunologi, Næringsstoffer, Systematisk gjennomgang og metaanalyse, Cognitive function
Published
2022

16. Food and chemical substances relevant for monitoring

Author

Svendsen, Camilla, Amlund, Heidi, Carlsen, Monica Hauger, Eriksen, Gunnar Sundstøl, Husøy, Trine, Lillegaard, Inger Therese Laugsand, Mathisen, Gro Haarklou, Medin, Anine Christine, Ørnsrud, Robin, Agdestein, Angelika, Bergh, Øivind, Bodin, Johanna Eva, Bruzell, Ellen Merete, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Velle, Gaute, Hemre, Gro Ingunn, Vandvik, Vigdis, and Alexander, Jan

Subjects
VDP::Medisinske Fag: 700::Helsefag: 800
Abstract

At request from the Norwegian Food Safety Authority (NFSA), VKM has identified food groups and food items consumed by the Norwegian population that are relevant for monitoring regarding content of one or more undesirable chemical substances (Figure 1). Undesirable chemical substances were defined as chemical substances in food that may constitute a potential health risk. Paid open access

Published
2022

22. Assessment of genetically modified maize MON 87427 × MON 87460 × MON 89034 × 1507 × MON 87411 × 59122 and sub-combinations, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2017‐139) - Scientific Opinion of the Panel on genetically modified organisms of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Duale, Nur, Jevnaker, Anne-Marthe Ganes, Sanden, Monica, Sipinen, Ville Erling, Thorstensen, Tage, and Vikse, Rose

Published
2022

24. Assessment of application EFSA-GMO-NL-2020-169 for authorisation to place on the market MON 94100 oilseed rape in the European Union, according to Regulation (EC) No 1829/2003 on genetically modified food and feed - Scientific Opinion of the Panel on genetically modified organisms of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Duale, Nur, Jevnaker, Anne-Marthe Ganes, Sanden, Monica, Sipinen, Ville Erling, Thorstensen, Tage, and Vikse, Rose

Published
2022

26. Assessment of genetically modified maize NK603 × T25 × DAS‐40278‐9 and sub-combinations, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐164) - Scientific Opinion of the Panel on genetically modified organisms of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Duale, Nur, Jevnaker, Anne-Marthe Ganes, Sanden, Monica, Sipinen, Ville Erling, Thorstensen, Tage, and Vikse, Rose

Published
2022

27. Food and chemical substances relevant for monitoring - Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Svendsen, Camilla, Amlund, Heidi, Carlsen, Monica Hauger, Eriksen, Gunnar Sundstøl, Husøy, Trine, Lillegaard, Inger Therese Laugsand, Mathisen, Gro Haarklou, Medin, Anine Christine, Ørnsrud, Robin, Agdestein, Angelika, Bergh, Øivind, Bodin, Johanna Eva, Bruzell, Ellen Merete, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Velle, Gaute, Hemre, Gro Ingunn, Vandvik, Vigdis, and Alexander, Jan

Published
2022

30. Clinical characteristics and outcomes in hospitalized adult influenza patients: an observational study from Norway 2014–2018

Author

Wæhre, Torgun, primary, Tunheim, Gro, additional, Bodin, Johanna Eva, additional, Laake, Ida, additional, Kvale, Dag, additional, Kran, Anne-Marte Bakken, additional, Brekke, Hanne, additional, Løken, Ragnhild, additional, Oftung, Fredrik, additional, Mjaaland, Siri, additional, and Dyrhol-Riise, Anne Margarita, additional

Published
2022
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31. Household Transmission of SARS-CoV-2: A Prospective Longitudinal Study Showing Higher Viral Load and Increased Transmissibility of the Alpha Variant Compared to Previous Strains

Author

Julin, Cathinka Halle, primary, Robertson, Anna Hayman, additional, Hungnes, Olav, additional, Tunheim, Gro, additional, Bekkevold, Terese, additional, Laake, Ida, additional, Aune, Idunn Forland, additional, Killengreen, Marit Fodnes, additional, Strand, Torunn Ramsem, additional, Rykkvin, Rikard, additional, Dorenberg, Dagny Haug, additional, Stene-Johansen, Kathrine, additional, Berg, Einar Sverre, additional, Bodin, Johanna Eva, additional, Oftung, Fredrik, additional, Steens, Anneke, additional, and Næss, Lisbeth Meyer, additional

Published
2021
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34. Household transmission of SARS-CoV-2; a prospective longitudinal study showing higher viral load and transmissibility of the Alpha variant compared to previous strains

Author

Julin, Cathinka Halle, primary, Robertson, Anna Hayman, additional, Hungnes, Olav, additional, Tunheim, Gro, additional, Bekkevold, Terese, additional, Laake, Ida, additional, Aune, Idunn Forland, additional, Rykkvin, Rikard, additional, Dorenberg, Dagny Haug, additional, Stene-Johansen, Kathrine, additional, Berg, Einar Sverre, additional, Bodin, Johanna Eva, additional, Oftung, Fredrik, additional, Steens, Anneke, additional, and Næss, Lisbeth Meyer, additional

Published
2021
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35. Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Thorstensen, Tage, Alsheikh, Muath K, Basic, Dean, Edvardsen, Rolf Brudvik, Dalen, Knut Tomas, Duale, Nur, Eklo, Ole Martin, Ergon, Åshild Gunilla, Jevnaker, Anne-Marthe Ganes, Hindar, Kjetil, Håvarstein, Leiv Sigve, Malmstrøm, Martin, Nielsen, Kaare Magne, Olsen, Siri Lie, Rueness, Eli Knispel, Sanden, Monica, Sipinen, Ville Erling, von Krogh, Kristine, Våge, Dag Inge, Wargelius, Anna, Wendell, Per Hans Micael, Yazdankhah, Siamak Pour, Alexander, Jan, Bruzell, Ellen Merete, Hemre, Gro Ingunn, Vandvik, Vigdis, Agdestein, Angelika, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Velle, Gaute, and Wasteson, Yngvild

Abstract

The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This report considers whether the risk assessment guidance on genetically modified organisms, developed by the European Food Safety Authority (EFSA), can be applied to evaluate potential risks of organisms developed by genome editing. Background Gene technology has allowed for the transfer of genes between organisms and species, and thereby to design altered genotypes with novel traits, i.e. GMOs. A new paradigm started in the early 2000s with the development of genome-editing techniques. Unlike traditional genetic modification techniques resulting in insertion of foreign DNA fragments at random locations in the genome, the new genome-editing techniques additionally open for a few single nucleotide edits or short insertions/deletions at a targeted site in an organism’s genome. These new techniques can be applied to most types of organisms, including plants, animals and microorganisms of commercial interest. An important question is how the novel, genome-edited organisms should be evaluated with respect to risks to health and the environment. The European Court of Justice decided in 2018 to include genome-edited organisms in the GMO definition and hence in the regulatory system already in place. This implies that all products developed by genome-editing techniques must be risk-assessed within the existing regulatory framework for GMOs. The European and Norwegian regulatory frameworks regulate the production, import and placing on the market of food and feed containing, consisting of or produced from GMOs, as well as the release of GMOs into the environment. The assessment draws on guidance documents originally developed by EFSA for risk assessment of GMOs, which were drawn up mainly to address risks regarding insertion of transgenes. The new genome-editing techniques, however, provide a new continuum of organisms ranging from those only containing a minor genetic alteration to organisms containing insertion or deletion of larger genomic regions. Risk assessment of organisms developed by genome editing The present discourse on how new genome-editing techniques should be regulated lacks an analysis of whether risk assessment methodologies for GMOs are adequate for risk assessment of organisms developed through the use of the new genome-editing techniques. Therefore, this report describes the use of genome-editing techniques in food and feed production and discusses challenges in risk assessment with the regulatory framework. Specifically, this report poses the question as to whether the EFSA guidance documents are sufficient for evaluating risks to health and environment posed by genome-edited plants, animals and microorganisms. To address these questions, the report makes use of case examples relevant for Norway. These examples, intended for food and feed, include oilseed rape with a modified fatty acid profile, herbicide-tolerant and pest-resistant crops, sterile salmon, virus-resistant pigs and hornless cattle. The report considers all aspects of the stepwise approach as described in the EFSA guidance documents. Conclusions The inherent flexibility of the EFSA guidance makes it suitable to cover health and environmental risk assessments of a wide range of organisms with various traits and intended uses. Combined with the embedded case-by-case approach the guidance is applicable to genome-edited organisms. The evaluation of the guidance demonstrates that the parts of the health and environmental risk assessment concerned with novel traits (i.e. the phenotype of the organism) may be fully applied to all categories of genome-edited organisms. ............

Published
2021

36. Genome editing in food and feed production – implications for risk assessment

Author

Bodin, Johanna Eva, Thorstensen, Tage, Alsheikh, Muath K, Basic, Dean, Edvardsen, Rolf Brudvik, Dalen, Knut Tomas, das Neves, Carlos Gonçalo, Duale, Nur, Eklo, Ole Martin, Ergon, Åshild Gunilla, Jevnaker, Anne-Marthe Ganes, Hindar, Kjetil, Håvarstein, Leiv Sigve, Malmstrøm, Martin, Nielsen, Kaare Magne, Olsen, Siri Lie, Rueness, Eli Knispel, Sanden, Monica, Sipinen, Ville Erling, Vikse, Rose, von Krogh, Kristine, Våge, Dag Inge, Wargelius, Anna, Wendell, Micael, Yazdankhah, Siamak Pour, Alexander, Jan, Bruzell, Ellen Merete, Hemre, Gro Ingunn, Vandvik, Vigdis, Agdestein, Angelika, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Velle, Gaute, and Wasteson, Yngvild

Abstract

The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This report considers whether the risk assessment guidance on genetically modified organisms, developed by the European Food Safety Authority (EFSA), can be applied to evaluate potential risks of organisms developed by genome editing.

Published
2021

37. Genome editing in food and feed production – implications for risk assessment. Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Thorstensen, Tage, Alsheikh, Muath, Basic, Dean, Edvardsen, Rolf Brudvik, Dalen, Knut Tomas, das Neves, Carlos Gonçalo, Duale, Nur, Eklo, Ole Martin, Ergon, Åshild Gunilla, Jevnaker, Anne-Marthe Ganes, Hindar, Kjetil, Håvarstein, Sigve, Malmstrøm, Martin, Nielsen, Kaare Magne, Olsen, Siri Lie, Rueness, Eli Knispel, Sanden, Monica, Sipinen, Ville Erling, Vikse, Rose, von Krogh, Kristine, Våge, Dag Inge, Wargelius, Anna Sofie Troedsson, Wendell, Per Hans Micael, Yazdankhah, Siamak Pour, Alexander, Jan, Bruzell, Ellen Merete, Hemre, Gro Ingunn, Vandvik, Vigdis, Agdestein, Angelika, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Knutsen, Helle Katrine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor Arne, Velle, Gaute, and Wasteson, Yngvild

Subjects
Genmodifiserte organismer, Risk assessments, Food production, Genetically modified organisms, CRISPR, Risikovurderinger, Genomredigering, Fôrproduksjon, Feed production, Genome editing, Matproduksjon
Abstract

The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This report considers whether the risk assessment guidance on genetically modified organisms, developed by the European Food Safety Authority (EFSA), can be applied to evaluate potential risks of organisms developed by genome editing.

Published
2021

38. Risk assessment of methylsulfonylmethane (MSM). Opinion of the Norwegian Scientific Committee for Food and Environment

Author

Bodin, Johanna Eva, Alexander, Jan, Caspersen, Ida Henriette, Duale, Nur, Mathisen, Gro Haarklou, Krogdahl, Åshild, Svendsen, Camilla, and Ørnsrud, Robin

Subjects
VDP::Klinisk medisinske fag: 750, Risikovurdering, Energi, Energy, Kosttilskudd, Food supplements, Statlige og kommunale myndigheter, Helseeffekter, State and local government, Health effects, VDP::Clinical medical sciences: 750, Risk assessment
Published
2021

39. Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice

Author

Hyötyläinen, Tuulia, Bodin, Johanna, Duberg, Daniel, Dirven, Hubert, Nygaard, Unni C, Oresic, Matej, Hyötyläinen, Tuulia, Bodin, Johanna, Duberg, Daniel, Dirven, Hubert, Nygaard, Unni C, and Oresic, Matej

Abstract

Exposure to Per- and polyfluoroalkyl substances (PFAS) has been linked to multiple undesirable health outcomes across a full lifespan, both in animal models as well as in human epidemiological studies. Immunosuppressive effects of PFAS have been reported, including increased risk of infections and suppressed vaccination responses in early childhood, as well as association with immunotoxicity and diabetes. On a mechanistic level, PFAS exposure has been linked with metabolic disturbances, particularly in lipid metabolism, but the underlying mechanisms are poorly characterized. Herein we explore lipidomic signatures of prenatal and early-life exposure to perfluoroundecanoic acid (PFUnDA) in non-obese diabetic (NOD) mice; an experimental model of autoimmune diabetes. Female NOD mice were exposed to four levels of PFUnDA in drinking water at mating, during gestation and lactation, and during the first weeks of life of female offspring. At offspring age of 11-12 weeks, insulitis and immunological endpoints were assessed, and serum samples were collected for comprehensive lipidomic analyses. We investigated the associations between exposure, lipidomic profile, insulitis grade, number of macrophages and apoptotic, active-caspase-3-positive cells in pancreatic islets. Dose-dependent changes in lipidomic profiles in mice exposed to PFUnDA were observed, with most profound changes seen at the highest exposure levels. Overall, PFUnDA exposure caused downregulation of phospholipids and triacylglycerols containing polyunsaturated fatty acids. Our results show that PFUnDA exposure in NOD mice alters lipid metabolism and is associated with pancreatic insulitis grade. Moreover, the results are in line with those reported in human studies, thus suggesting NOD mice as a suitable model to study the impacts of environmental chemicals on T1D., Funding agency:Norwegian Institute of Public Health

Published
2021
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42. Protocol and description of literature searches for the risk-benefit assessment of fish in the Norwegian diet. The Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Andersen, Lene Frost, Berstad, Paula, Carlsen, Monica Hauger, Dahl, Lisbeth, Goksøyr, Anders, Knutsen, Helle Katrine, Kvestad, Ingrid, Lillegaard, Inger Therese Laugsand, Mangschou, Bente, Meyer, Haakon E, Nauta, Maarten, Rakkestad, Kirsten Eline, Rasinger, Josef Daniel, Skeie, Guri, Starrfelt, Jostein, Thomsen, Sofie, Ulven, Stine Marie, Agdestein, Angelika, Bodin, Johanna Eva, Elvevoll, Edel O., Hessen, Dag Olav, Husøy, Trine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Skjerdal, Olaug Taran, Steffensen, Inger-Lise Karin, Strand, Tor A, Velle, Gaute, Wasteson, Yngvild, Hemre, Gro Ingunn, Vandvik, Vigdis, and Alexander, Jan

Abstract

publishedVersion

Published
2020

43. Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Author

McGlinchey, Aidan J, Sinioja, Tim, Lamichhane, Santosh, Sen, Partho, Bodin, Johanna, Siljander, Heli, Dickens, Alex M., Geng, Dawei, Carlsson, Cecilia, Duberg, Daniel, Ilonen, Jorma, Virtanen, Suvi M., Dirven, Hubert, Berntsen, Hanne Friis, Zimmer, Karin, Nygaard, Unni C., Oresic, Matej, Knip, Mikael, Hyötyläinen, Tuulia, McGlinchey, Aidan J, Sinioja, Tim, Lamichhane, Santosh, Sen, Partho, Bodin, Johanna, Siljander, Heli, Dickens, Alex M., Geng, Dawei, Carlsson, Cecilia, Duberg, Daniel, Ilonen, Jorma, Virtanen, Suvi M., Dirven, Hubert, Berntsen, Hanne Friis, Zimmer, Karin, Nygaard, Unni C., Oresic, Matej, Knip, Mikael, and Hyötyläinen, Tuulia

Abstract

In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring., Funding Agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)1DP3DK094338-01Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research 250114Academy of Finland postdoctoral grant 323171Medical Research Funds, Tampere University Hospital Juvenile Diabetes Research Foundation 2-SRA-2016-341-S-B 2-SRA-2016-289-S-BMedical Research Funds, Helsinki University Hospital

Published
2020
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44. Clinical risk scores as predictors of severe outcome in hospitalized influenza patients: an observational cohort study from Norway 2014-2018

Author

Wæhre, Torgun, primary, Tunheim, Gro, additional, Bodin, Johanna, additional, Laake, Ida, additional, Kvale, Dag, additional, Kran, Anne-Marte, additional, Brekke, Hanne, additional, Løken, Ragnhild, additional, Oftung, Fredrik, additional, Mjaaland, siri, additional, and Riise, Anne Margarita Dyrhol, additional

Published
2020
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45. Microplastics; occurrence, levels and implications for environment and human health related to food. Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Skåre, Janneche Utne, Alexander, Jan, Haave, Marte, Jakubowicz, Ignacy, Knutsen, Helle Katrine, Lusher, Amy, Ogonowski, Martin, Rakkestad, Kirsten Eline, Skaar, Ida, Sverdrup, Line Emilie, Wagner, Martin, Agdestein, Angelika, Bodin, Johanna Eva, Elvevoll, Edel O., Hemre, Gro Ingunn, Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise, Strand, Tor A, Vandvik, Vigdis, and Wasteson, Yngvild

Abstract

Report from the Norwegian Scientific Committee for Food Safety (VKM) 2019:16. Microplastics; occurrence, levels and implications for environment and human health related to food. Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment. Source at https://www.vkm.no/. The steering committee of VKM has self-initiated a mandate for an opinion on microplastics based on recently published international and/or national reports complemented with literature from December 2016 to February 2019. The mandate requested a summary of the state of knowledge on the presence of microplastics in the environment and the implications for the ecosystem, terrestrial and aquatic organisms, food production and human health. An overview of main national and international ongoing initiatives was also requested, and highlighting of data gaps where specific Norwegian data was needed.

Published
2019

46. Microplastics; occurrence, levels and implications for environment and human health related to food. Scientific opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment

Author

Skåre, Janneche Utne, Alexander, Jan, Haave, Marte, Jakubowicz, Ignacy, Knutsen, Helle Katrine, Lusher, Amy, Ogonowski, Martin, Rakkestad, Kirsten Eline, Skaar, Ida, Sverdrup, Line Emilie, Wagner, Martin, Agdestein, Angelika, Bodin, Johanna Eva, Elvevoll, Edel O., Hemre, Gro Ingunn, Hessen, Dag Olav, Hofshagen, Merete, Husøy, Trine, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Steffensen, Inger-Lise, Strand, Tor A, Vandvik, Vigdis, and Wasteson, Yngvild

Abstract

publishedVersion

Published
2019

47. Ranking of substances for monitoring in foods, drinks and dietary supplements - based on risk and knowledge gaps

Author

Steffensen, Inger-Lise, Fæste, Christiane Kruse, Husøy, Trine, Knutsen, Helle Katrine, Mathisen, Gro Haarklou, Ørnsrud, Robin, Agdestein, Angelika, Bodin, Johanna Eva, Elvevoll, Edel O., Hessen, Dag Olav, Hofshagen, Merete, Krogdahl, Åshild, Nilsen, Asbjørn Magne, Rafoss, Trond, Skjerdal, Olaug Taran, Velle, Gaute, Wasteson, Yngvild, Hemre, Gro Ingunn, Vandvik, Vigdis, and Alexander, Jan

Subjects
Forurensning / Pollution, Forurensning, Metaller / Metals, Metaller, Gifter/toksiner / Toxins, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710, Pollution, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710, Matkontaktmaterialer, Gifter/toksiner, Metals, Food contact materials, Matkontaktmaterialer / Food contact materials, Organic pollutants, Toxins, Organiske miljøgifter / Organic pollutants, Organiske miljøgifter
Abstract

Source at https://vkm.no/download/18.7d363f6e16d16151068849d0/1568620629508/Ranking%20of%20substances%20for%20monitoring%20in%20foods,%20drinks%20and%20dietary%20supplements.pdf The Norwegian Food Safety Authority (NFSA) requested the Norwegian Scientific Committee for Food and Environment (VKM) to provide an overview of substances in foods, drinks and dietary supplements that may constitute a potential health risk for humans, based on the VKM members’ expert judgements. VKM was further requested to perform a ranking of these substances. Additionally, VKM should give an overiview of the foods, drinks and dietary supplements most relevant for monitoring, and describe what would be the adequate sampling procedure and number of samples. Monitoring procedures were included to ensure that the monitoring performed is representative for the occurrence of the substances in foods, drinks and/or dietary supplements consumed by the Norwegian population. The substances requested to be included were food additives and flavourings, substances used in food contact materials, environmental contaminants, process-induced substances and natural toxins. Substances not to be included were veterinary medicine residues, illegal pharmaceuticals and pesticide residues. The overview provided by VKM included substances belong to the following groups and subgroups of substances: Natural toxins; with the sub-groups mycotoxins, plant toxins, marine and freshwater algae toxins Metals and metalloids Persistent organic pollutants (POPs); with the sub-groups brominated flame retardants, dechloranes, dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs), non-dioxin-like polychlorinated biphenyls (NDL-PCBs), perfluorinated and polyfluorinated alkyl substances (PFAS) and siloxanes Substances in food contact materials; with the sub-groups bisphenols and phthalates Flavourings Additives; with the sub-groups nitrites and nitrates, phosphates, sweeteners and synthetic antioxidants Process-induced contaminants; with the sub-groups acrylamide, esterified 3- and 2- monochloropropane-1,2-diol (MCPD), glycidyl fatty esters (GEs), furans, heterocyclic aromatic amines (HAAs) and polycyclic aromatic hydrocarbons (PAHs) «Other substances» Trace elements The ranking of the substances is based on inherent toxicity (hazard) and level of exposure (both occurrence and intake). In addition, vulnerable groups, adequacy of toxicity data and lack of exposure data were considered. A simple methodology was chosen. More advanced methodology may be used in later updates of this ranking, if found useful.

Published
2019

48. Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Author

McGlinchey, Aidan, primary, Sinioja, Tim, additional, Lamichhane, Santosh, additional, Sen, Partho, additional, Bodin, Johanna, additional, Siljander, Heli, additional, Dickens, Alex M., additional, Geng, Dawei, additional, Carlsson, Cecilia, additional, Duberg, Daniel, additional, Ilonen, Jorma, additional, Virtanen, Suvi M., additional, Dirven, Hubert, additional, Berntsen, Hanne Friis, additional, Zimmer, Karin, additional, Nygaard, Unni C., additional, Orešič, Matej, additional, Knip, Mikael, additional, and Hyötyläinen, Tuulia, additional

Published
2019
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49. Vitamin D Deficiency is Associated with Increased Use of Antimicrobials among Preschool Girls in Ethiopia

Author

Bodin, Johanna, primary, Mihret, Adane, additional, Holm-Hansen, Carol, additional, Dembinski, Jennifer, additional, Trieu, Mai-Chi, additional, Tessema, Bamlak, additional, Tarekegne, Azeb, additional, Yimer, Solomon, additional, Cox, Rebecca, additional, Aseffa, Abraham, additional, Haneberg, Bjørn, additional, and Mjaaland, Siri, additional

Published
2019
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50. Bisphenol A (Bpa) Hazard Assessment Protocol

Author

European Food Safety Authority (EFSA), Gundert-Remy, Ursula, Bodin, Johanna, Bosetti, Cristina, FitzGerald, Rex, Hanberg, Annika, Hass, Ulla, Hooijmans, Carlijn, Rooney, Andrew A., Rousselle, Christophe, van Loveren, Henk, Wölfle, Detlef, Barizzone, Fulvio, Croera, Cristina, Putzu, Claudio, Castoldi, Anna F., Husøy, Trine, Munoz Guajardo, Irene, Smeraldi, Camilla, and Castoldi, Anna F.

Subjects
Hazard assessment methodology, External validity, Evidence integration, Protocol, Weight of evidence, BPA, Internal validity
Abstract

To ensure an efficient, transparent and methodologically rigorous re-assessment of the safety for consumers of bisphenol A (BPA), the European Food Safety Authority (EFSA) has undertaken the task to develop a protocol detailing a priori the approach and methodology for performing BPA hazard identification and characterisation. The general aim of this hazard assessment will be to assess whether the new scientific evidence (published from 2013 onwards and not previously appraised by EFSA) still supports the current temporary Tolerable Daily Intake (t-TDI) for BPA of 4 µg/kg bw per day. In line with the principles highlighted in the EFSA project PROmoting METHods for Evidence Use in scientific assessments (PROMETHEUS, https://www.efsa.europa.eu/en/efsajournal/pub/4121), the protocol states upfront and in detail the methods and/or the criteria that will be used in the planned BPA re-evaluation for data collection, study inclusion, evidence appraisal and integration. To pursue the goal of openness, this protocol was subjected to a web-based public consultation and was presented publicly in a stakeholder event. All the relevant comments and feedback received through these procedures were considered.

Published
2017
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