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344 results on '"Bondavalli F"'

8. Synthesis and pharmacological profile of novel N-substituted N-[5H-[1]benzopyrano[4,3-d]pyrimidin-2-YL]-N-methylglycinamides

Author

Bruno, O., Schenone, S., Ranise, A., Bondavalli, F., michele d'amico, Filippelli, W., Berrino, L., Rossi, F., Bruno, O, Schenone, S, Ranise, A, Bondavalli, F, D'Amico, Michele, Filippelli, W, Berrino, Liberato, and Rossi, Francesco

Subjects
Mice, Anti-Inflammatory Agents, Glycine, Animals, Anti-Arrhythmia Agents, Antihypertensive Agents, Rats
Abstract

The title compounds were synthesized by cyclizing 3-dimethylaminomethylene-4-chromanone with creatine to give the acid 2 that was successively converted into the corresponding amides 3a-f via diphenylphosphorylazide and the relevant amines. The free acid 2 and some of 3a-f showed antiinflammatory, hypotensive and antiarrhythmic properties.

Published
1996

11. 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities

Author

Schenone, S., Bruno, O., Ranise, A., Bondavalli, F., michele d'amico, Filippelli, W., Falcone, G., Novellis, V., Schenone, S, Bruno, O, Ranise, A, Bondavalli, F, D'Amico, Michele, Filippelli, W, Falcone, G, and DE NOVELLIS, Vito

Subjects
Analgesics, Aniline Compounds, Indazoles, Fever, Platelet Aggregation, Anti-Inflammatory Agents, Non-Steroidal, Carrageenan, Rats, Mice, Animals, Edema, Anesthetics, Local, Anti-Arrhythmia Agents, Antihypertensive Agents, Platelet Aggregation Inhibitors
Abstract

The synthesis of novel 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles 4a-f, starting from N-phenyl-3,4-dihydro-1(2H)-oxonaphthalene-2-carbothioamide and the proper arylhydrazines, is described. Title compounds were evaluated for antiinflammatory, analgesic, antipyretic, antiarrhythmic, hypotensive, local anaesthetic and platelet antiaggregating activities; some of them showed an appreciable antiarrhythmic activity in rats and a good level of infiltration anaesthesia in mice.

Published
1995

12. 5-[[omega-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo [2.2.2.]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities

Author

SCHENONE S, BRUNO O, RANISE A, BONDAVALLI F, D'AMICO, Michele, PIU M, FILIPPELLI W, BERRINO, Liberato, Schenone, S, Bruno, O, Ranise, A, Bondavalli, F, D'Amico, Michele, Piu, M, Filippelli, W, and Berrino, Liberato

Subjects
Bridged Bicyclo Compounds, Mice, Animals, Analgesics, Non-Narcotic, Anesthetics, Local, Anti-Arrhythmia Agents, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of 5-[[omega-(dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-ones by reaction of (+)-5-(hydroxymethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan- 6-one with a series of omega-(chloroalkyl)dialkylamines in the presence of potassium carbonate is described. Some compounds showed strong hypotensive, local anesthetic and antiarrhythmic activity in rats and mice, as well as moderate analgesic, antipyretic and in vitro platelet antiaggregating activity.

Published
1994

13. O-[omega-(Dialkylamino)alkyl]oximes of (+)-1,7,7-trimethylbicyclo [2.2.1]heptan-2-one with hypotensive, antiinflammatory, analgesic, local anesthetic and other activities

Author

SCHENONE S, BRUNO O, RANISE A, BONDAVALLI F, VACCA C, FALCIANI M, FILIPPELLI A., D'AMICO, Michele, Schenone, S, Bruno, O, Ranise, A, Bondavalli, F, D'Amico, Michele, Vacca, C, Falciani, M, and Filippelli, A.

Subjects
Analgesics, Bridged Bicyclo Compounds, Mice, Anti-Inflammatory Agents, Non-Steroidal, Oximes, Animals, Analgesics, Non-Narcotic, Anesthetics, Local, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one O-[omega-(dialkylamino)alkyl]oximes by reaction of (+)-camphoroxime sodium salt with a series of omega-(chloroalkyl)dialkylamines in DMF solution is described. Some of the above compounds showed strong hypotensive, antiinflammatory, analgesic and local anesthetic activity in rats and mice, as well as moderate antiarrhythmic, antipyretic and in vitro platelet antiaggregating activity.

Published
1994

14. 3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities

Author

Bruno, O., Ranise, A., Bondavalli, F., Schenone, S., michele d'amico, Falciani, M., Vacca, C., Filippelli, A., Bruno, O, Ranise, A, Bondavalli, F, Schenone, S, D'Amico, Michele, Falciani, M, Vacca, C, and Filippelli, A.

Subjects
Analgesics, Mice, Local, chemical synthesis/pharmacology, Anesthetics, chemical synthesis/pharmacology, Animals, Mice, Platelet Aggregation Inhibitors, chemical synthesis/pharmacology, Pyrazoles, chemical synthesis/pharmacology, Rats, chemical synthesis/pharmacology, Animals, Pyrazoles, Anesthetics, Local, Platelet Aggregation Inhibitors, Anesthetics, Rats
Abstract

The synthesis of 4-amino-3,5-diphenyl-1H-pyrazole-1-ethanol, as well as of their N-methyl, N-ethyl and N,N-dimethyl derivatives is described. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazole-4-amines and of N-substituted 4-dimethylamino-3,5-diphenyl-1H-pyrazole-1-ethanamines were also prepared. Some of the above compounds showed remarkable local anesthetic, analgesic and in vitro platelet antiaggregating activities, as well as moderate antiinflammatory and antipyretic activities in rats and mice.

Published
1994

15. 5-Substituted 2,3-dihydro-6-mercapto-1,3-diphenyl-2-thioxo-4(3H)-pyrimidinones and their 6-(acylthio) derivatives with platelet antiaggregating, antiinflammatory, antiarrhythmic, antihyperlipidemic and other activities

Author

Ranise, A., Bruno, O., Bondavalli, F., Schenone, S., michele d'amico, Falciani, M., Filippelli, W., Rossi, F., Ranise, A, Bruno, O, Bondavalli, F, Schenone, S, D'Amico, Michele, Falciani, M, Filippelli, W, and Rossi, Francesco

Subjects
Mice, Anti-Inflammatory Agents, Non-Steroidal, Animals, Hypoglycemic Agents, Anticonvulsants, Pyrimidinones, Anesthetics, Local, Anti-Arrhythmia Agents, Platelet Aggregation Inhibitors, Hypolipidemic Agents, Rats
Abstract

The synthesis in excellent yields of 2,3-dihydro-6-mercapto-1,3,5-triphenyl-2-thioxo-4(3H)-pyrimidinone 3 and 5-ethoxycarbonyl-2,3-dihydro-6-mercapto-1,3-diphenyl-2-thioxo-4(3H )- pyrimidinone 4 by reaction of methyl phenylacetate or diethyl malonate, respectively, with phenyl isothiocyanate (3 molar equivalents) and sodium hydride (2 molar equivalents) in DMF solution is described. Acylation of 3 and 4 with acyl chlorides gave, generally in satisfactory yields, 6-acylthio derivatives 13 and 14. Some of the above compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as remarkable antiinflammatory, antiarrhythmic, local anesthetic and antihyperlipidemic activities in rats and in mice. Weak anticonvulsant and hypoglycemic activities were also detected.

Published
1994

21. N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities

Author

BRUNO O, RANISE A, BONDAVALLI F, SCHENONE P, D'AMICO, Michele, FILIPPELLI A, FALCIANI M, ROSSI, Francesco, Bruno, O, Ranise, A, Bondavalli, F, Schenone, P, D'Amico, Michele, Filippelli, A, Falciani, M, and Rossi, Francesco

Subjects
Magnetic Resonance Spectroscopy, Fever, Spectrophotometry, Infrared, Anti-Inflammatory Agents, Non-Steroidal, Blood Pressure, Carrageenan, Rats, Mice, Ventricular Fibrillation, Animals, Edema, Pyrazoles, Antihypertensive Agents, Platelet Aggregation Inhibitors, Pain Measurement
Abstract

The synthesis of N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines by reaction of N-substituted 3-oxo-2,3-diphenylpropane-carbothioamides with hydrazine is described. Some compounds showed remarkable antipyretic, antiarrhythmic and hypotensive activity in rats, as well as weak antiinflammatory, analgesic and in vitro platelet antiaggregating activity.

Published
1993

22. N-acyl-4,7,7-trimethyl-N-phenyl-3-(1-piperidinyl or dimethylamino)bicyclo[2.2.1]hept-2-ene-2-carbothioamides with platelet antiaggregating and other activities

Author

Ranise, A., Bruno, O., Bondavalli, F., Schenone, P., michele d'amico, Falzarano, C., Filippelli, A., Lampa, E., Ranise, A, Bruno, O, Bondavalli, F, Schenone, P, D'Amico, Michele, Falzarano, C, Filippelli, A, and Lampa, E.

Subjects
Anti-Inflammatory Agents, Non-Steroidal, Guinea Pigs, In Vitro Techniques, Acetylcholine, Rats, Thioamides, Bridged Bicyclo Compounds, Mice, Piperidines, Histamine H1 Antagonists, Animals, Humans, Antihypertensive Agents, Platelet Aggregation Inhibitors
Abstract

A series of N-acyl-4,7,7-trimethyl-N-phenyl-3-(1-piperidinyl or dimethylamino)bicyclo[2.2.1]hept-2-ene-2-carbothioamides was prepared in excellent yields by reaction of 4,7,7-trimethyl-N-phenyl-3-(1-piperidinyl or dimethylamino)bicyclo[2.2.1]hept-2-ene-2-carbothioamides with a number of aromatic or heterocyclic acyl chlorides in dry pyridine solution and in the presence of sodium hydride. Some of the above compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid; moreover, some compounds exhibited moderate analgesic, antiinflammatory and hypotensive activities in mice or rats.

Published
1993

25. N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]-octan-6-ones with platelet antiaggregating and local anesthetic activities

Author

Schenone, S., Bruno, O., Ranise, A., Bondavalli, F., michele d'amico, Parrillo, C., Lampa, E., Rossi, F., Schenone, S, Bruno, O, Ranise, A, Bondavalli, F, D'Amico, Michele, Parrillo, C, Lampa, E, and Rossi, Francesco

Subjects
Male, Analgesics, Bridged Bicyclo Compounds, Mice, Oximes, Animals, Humans, Anesthetics, Local, In Vitro Techniques, Anti-Arrhythmia Agents, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of a series of N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]octan-6-ones is described. Some of these ethers showed strong local anesthetic activity in mice and platelet antiaggregating activity in vitro comparable to that of acetylsalicylic acid, as well as moderate hypotensive, antiarrhythmic and analgesic activities in rats and mice.

Published
1992

26. 3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities

Author

Bruno, O., Ranise, A., Bondavalli, F., Schenone, P., michele d'amico, Lampa, E., Falzarano, C., Rossi, F., Bruno, O, Ranise, A, Bondavalli, F, Schenone, P, D'Amico, Michele, Lampa, E, Falzarano, C, and Rossi, Francesco

Subjects
Male, Mice, Anti-Inflammatory Agents, Non-Steroidal, Animals, Humans, Pyrazoles, In Vitro Techniques, Motor Activity, Anti-Arrhythmia Agents, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The syntheses of 1-(2-hydroxypropyl)-3,5-diphenyl-1H-pyrazole 1 by reaction of 1-hydrazino-2-propanol with dibenzoylmethane and of N-substituted 1-(2-aminopropyl)-3,5-diphenyl-1H-pyrazoles 3 by reaction of primary and secondary amines with the tosylate of 1, as well as of N-substituted 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles 6 starting from 3,5-diphenyl-1H-pyrazole, are described. Some compounds 3 and 6 showed remarkable antiinflammatory activity in rats, as well as weak analgesic, antipyretic, antiarrhythmic, hypotensive activities in mice and rats and moderate platelet antiaggregating effects in vitro.

Published
1992

40. ChemInform Abstract: 3,5-Diphenyl-1H-pyrazole Derivatives. Part 6. Esters and 2- Dialkylaminoethyl Ethers of 1-(2-Hydroxy-2-phenylethyl)-3,5-diphenyl- 1H-pyrazole and N,N-Disubstituted 1-(2-Amino-2-phenylethyl)-3,5- diphenyl-1H-pyrazoles with Depressant a

Author

BONDAVALLI, F., primary, BRUNO, O., additional, RANISE, A., additional, SCHENONE, P., additional, LOSASSO, C., additional, STELLA, L., additional, DE PAOLA, C., additional, IOIA, N., additional, and MARMO, E., additional

Published
2010
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41. ChemInform Abstract: 3,5-Diphenyl-1H-pyrazole Derivatives. Part 8. N-Substituted 3-(4- Hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines, and 2-(4-Hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-ethanamines with Platelet Antiaggregating, Hypotensive

Author

BRUNO, O., primary, BONDAVALLI, F., additional, RANISE, A., additional, SCHENONE, P., additional, CENICOLA, M. L., additional, DONNOLI, D., additional, FILIPPELLI, W., additional, LOSASSO, C., additional, COSTANTINO, M., additional, and MARMO, E., additional

Published
2010
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