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1. Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1)

Author

Ohnstad, H.O., Blix, E.S., Akslen, L.A., Gilje, B., Raj, S.X., Skjerven, H., Borgen, E., Janssen, E.A.M., Mortensen, E., Brekke, M.B., Falk, R.S., Schlichting, E., Boge, B., Songe-Møller, S., Olsson, P., Heie, A., Mannsåker, B., Vestlid, M.A., Kursetgjerde, T., Gravdehaug, B., Suhrke, P., Sanchez, E., Bublevic, J., Røe, O.D., Geitvik, G.A., Halset, E.H., Rypdal, M.C., Langerød, A., Lømo, J., Garred, Ø., Porojnicu, A., Engebraaten, O., Geisler, J., Lyngra, M., Hansen, M.H., Søiland, H., Nakken, T., Asphaug, L., Kristensen, V., Sørlie, T., Nygård, J.F., Kiserud, C.E., Reinertsen, K.V., Russnes, H.G., and Naume, B.

Published
2024
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3. 103P Impact of Prosigna test on treatment decision in lymph node-negative early breast cancer: A prospective multicenter study (EMIT1)

Author

Ohnstad, H.O., primary, Borgen, E., additional, Mortensen, E., additional, Brekke, M.B., additional, Akslen, L.A., additional, Janssen, E.A.M., additional, Geitvik, G.A., additional, Rypdal, M.C., additional, Langerød, A., additional, Halset, E.H., additional, Blix, E.S., additional, Raj, S.X., additional, Eikesdal, H.P., additional, Gilje, B., additional, Skjerven, H., additional, Sclichting, E., additional, Reinertsen, K.V., additional, Falk, R.S., additional, Russnes, H.E.G., additional, and Naume, B., additional

Published
2023
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4. 215MO ICON – a randomized phase IIb study evaluating chemotherapy combined with ipilimumab and nivolumab in metastatic hormone receptor-positive breast cancer

Author

Kyte, J.A., primary, Andresen, N.K., additional, Quaghebeur, C., additional, Gilje, B., additional, Boge, B., additional, Gombos, A., additional, Røssevold, A., additional, Mathiesen, R.M.R., additional, Borgen, E., additional, Falk, R.S., additional, Julsrud, L., additional, Russnes, H.G., additional, Lingjærde, O.C., additional, and Naume, B., additional

Published
2022
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5. Circulating tumor cells in patients with metastatic castration resistant prostate cancer: exploratory findings at a tertiary referral hospital

Author

Fosså SD, Hess SL, Paus E, and Borgen E

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Sophie D Fosså,1 Siri L Hess,1 Elisabeth Paus,2 Elin Borgen3 1National Resource Center for Late Effects after Cancer Treatment, 2Department of Medical Biochemistry, 3Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Radiumhospital, Oslo, Norway Objectives: In patients with metastatic castration-resistant prostate cancer (mCRPC), the finding of less than five circulating tumor cells (CTCs)/7.5 mL blood before start of cytotoxic treatment or shortly thereafter indicates prolonged survival. In this descriptive pilot study, we investigated whether this association depends on the sequence of the therapeutic attempts. Patients and methods: CTCs were determined in 41 mCRPC patients before and 2–3 months after starting first-line treatment with docetaxel (group 1) or second-line treatment with either radium-223 (group 2) or placebo/best supportive care (group 3). A "favorable" CTC count was defined as

Published
2014

6. DNA copy number motifs are strong and independent predictors of survival in breast cancer

Author

Pladsen, A.V., Nilsen, G., Rueda, O.M., Aure, M.R., Borgan, Ø., Liestøl, K., Vitelli, V., Frigessi, A., Langerød, A., Mathelier, A., Bathen, T.F., Borgen, E., Børresen-Dale, A.-L., Engebråten, O., Fritzman, B., Garred, Ø., Geisler, J., Geitvik, G.A., Hofvind, S., Kristensen, V., Kåresen, R., Lingjærde, O.C., Mælandsmo, G.M., Naume, B., Russnes, H.G., Sahlberg, K.K., Sauer, T., Skjerven, H.K., Schlichting, E., Sørlie, T., Wedge, D.C., Van Loo, P., Caldas, C., Pladsen, Arne V [0000-0001-7765-6823], Rueda, Oscar M [0000-0003-0008-4884], Mathelier, Anthony [0000-0001-5127-5459], Wedge, David C [0000-0002-7572-3196], Van Loo, Peter [0000-0003-0292-1949], Caldas, Carlos [0000-0003-3547-1489], Russnes, Hege G [0000-0001-8724-1891], Lingjærde, Ole Christian [0000-0003-3565-4912], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Genome instability, Gene Dosage, Medicine (miscellaneous), Tumour biomarkers, chemistry.chemical_compound, Breast cancer, 0302 clinical medicine, Risk Factors, Databases, Genetic, Cancer genomics, Computational models, lcsh:QH301-705.5, Manchester Cancer Research Centre, food and beverages, Middle Aged, Prognosis, 3. Good health, 030220 oncology & carcinogenesis, Female, General Agricultural and Biological Sciences, Algorithms, DNA Copy Number Variations, Clinical Decision-Making, Breast Neoplasms, Computational biology, Biology, Risk Assessment, Article, General Biochemistry, Genetics and Molecular Biology, Genomic Instability, 03 medical and health sciences, Predictive Value of Tests, medicine, Biomarkers, Tumor, Humans, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Gene Expression Profiling, fungi, Cancer, medicine.disease, 030104 developmental biology, chemistry, lcsh:Biology (General), Spatial behavior, Personalized medicine, business, Outcome prediction, Transcriptome, Genome architecture, DNA
Abstract

Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome prediction and treatment guidance. Here we show that the local spatial behavior of copy number profiles conveys important information about this architecture. Six filters were defined to characterize regional traits in copy number profiles, and the resulting Copy Aberration Regional Mapping Analysis (CARMA) algorithm was applied to tumors in four breast cancer cohorts (n = 2919). The derived motifs represent a layer of information that complements established molecular classifications of breast cancer. A score reflecting presence or absence of motifs provided a highly significant independent prognostic predictor. Results were consistent between cohorts. The nonsite-specific occurrence of the detected patterns suggests that CARMA captures underlying replication and repair defects and could have a future potential in treatment stratification., Pladsen et al. develop Copy Aberration Regional Mapping Analysis (CARMA), an algorithm that derives motifs for copy number profiles in breast cancers by integrating several features, to predict breast cancer prognosis and stratifications. Their algorithm can detect replication and repair defects and can be used in personalized medicine.

Published
2020

10. International pooled analysis of the prognostic impact of disseminated tumor cells from the bone marrow in early breast cancer : Results from the PADDY study

Author

Hartkopf, AD, Brucker, SY, Taran, F-A, Harbeck, N, von Au, A, Naume, B, Pierga, J-Y, Hoffmann, O, Beckmann, MW, Rydén, L, Fehm, T, Aft, R, Montserrat, S, Walter, V, Rack, B, Schuetz, F, Borgen, E, Ta, M-H, Bittner, A-K, Fasching, P, Fernö, M, Krawczyk, N, Weilbaecher, K, Margelí, M, Hahn, M, Jueckstock, J, Domschke, C, Bidard, F-C, Kasimir-Bauer, Sabine, Schoenfisch, B, Kurt, AG, Wallwiener, M, Gebauer, G, Wallwiener, D, Janni, W, and Pantel, K

Subjects
Medizin
Published
2019

14. Abstract GS5-07: International pooled analysis of the prognostic impact of disseminated tumor cells from the bone marrow in early breast cancer: Results from the PADDY study

Author

Hartkopf, AD, primary, Brucker, SY, additional, Taran, F-A, additional, Harbeck, N, additional, von Au, A, additional, Naume, B, additional, Pierga, J-Y, additional, Hoffmann, O, additional, Beckmann, MW, additional, Rydén, L, additional, Fehm, T, additional, Aft, R, additional, Montserrat, S, additional, Walter, V, additional, Rack, B, additional, Schuetz, F, additional, Borgen, E, additional, Ta, M-H, additional, Bittner, A-K, additional, Fasching, P, additional, Fernö, M, additional, Krawczyk, N, additional, Weilbaecher, K, additional, Margelí, M, additional, Hahn, M, additional, Jueckstock, J, additional, Domschke, C, additional, Bidard, F-C, additional, Kasimir-Bauer, S, additional, Schoenfisch, B, additional, Kurt, AG, additional, Wallwiener, M, additional, Gebauer, G, additional, Wallwiener, D, additional, Janni, W, additional, and Pantel, K, additional

Published
2019
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15. Abstract P6-07-01: A translational and five-year clinical update in patients treated with neoadjuvant chemotherapy randomized to bevacizumab or control in HER2 negative breast cancer

Author

Gythfeldt, HvdL, primary, Engebråten, O, additional, Naume, B, additional, Wist, E, additional, Borgen, E, additional, Lien, T, additional, Lindgjærde, OC, additional, Garred, O, additional, Schlichting, E, additional, Silwal-Pandit, L, additional, and Borresen-Dale, AL, additional

Published
2019
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16. Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis.

Author

Bidard, François-Clément, Michiels, Stefan, Riethdorf, Sabine, Mueller, Volkmar, Esserman, Laura J, Lucci, Anthony, Naume, Bjorn, Horiguchi, Jun, Gisbert-Criado, Rafael, Sleijfer, Stefan, Toi, Masakazu, Garcia-Saenz, Jose A, Hartkopf, Andreas, Generali, Daniele, Rothé, Françoise, Smerage, Jeffrey, Muinelo-Romay, Laura, Stebbing, Justin, Viens, Patrice, Magbanua, Mark Jesus MJM, Hall, Carolyn S, Engebraaten, Olav, Takata, Daisuke, Vidal-Martínez, José, Onstenk, Wendy, Fujisawa, Noriyoshi, Diaz-Rubio, Eduardo, Tarantino, Franca, Cappelletti, M L, Ignatiadis, Michail, Proudhon, Charlotte, Wolf, Denise M, Bauldry, Jessica JB, Borgen, E, Nagaoka, Rin, Carañana, Vicente, Kraan, Jaco, Maestro, Marisa, Brucker, Sara Yvonne, Weber, Karsten, Reyal, Fabien, Amara, Dominic, Karhade, Mandar MG, Mathiesen, Randi RR, Tokiniwa, Hideaki, Llombart-Cussac, Antonio, Meddis, Alessandra, Blanche, Paul, d'Hollander, Koenraad, Cottu, Paul, Park, John W, Loibl, Sibylle, Latouche, Aurelien, Pierga, Jean-Yves, Pantel, Klaus, Bidard, François-Clément, Michiels, Stefan, Riethdorf, Sabine, Mueller, Volkmar, Esserman, Laura J, Lucci, Anthony, Naume, Bjorn, Horiguchi, Jun, Gisbert-Criado, Rafael, Sleijfer, Stefan, Toi, Masakazu, Garcia-Saenz, Jose A, Hartkopf, Andreas, Generali, Daniele, Rothé, Françoise, Smerage, Jeffrey, Muinelo-Romay, Laura, Stebbing, Justin, Viens, Patrice, Magbanua, Mark Jesus MJM, Hall, Carolyn S, Engebraaten, Olav, Takata, Daisuke, Vidal-Martínez, José, Onstenk, Wendy, Fujisawa, Noriyoshi, Diaz-Rubio, Eduardo, Tarantino, Franca, Cappelletti, M L, Ignatiadis, Michail, Proudhon, Charlotte, Wolf, Denise M, Bauldry, Jessica JB, Borgen, E, Nagaoka, Rin, Carañana, Vicente, Kraan, Jaco, Maestro, Marisa, Brucker, Sara Yvonne, Weber, Karsten, Reyal, Fabien, Amara, Dominic, Karhade, Mandar MG, Mathiesen, Randi RR, Tokiniwa, Hideaki, Llombart-Cussac, Antonio, Meddis, Alessandra, Blanche, Paul, d'Hollander, Koenraad, Cottu, Paul, Park, John W, Loibl, Sibylle, Latouche, Aurelien, Pierga, Jean-Yves, and Pantel, Klaus

Abstract

We conducted a meta-analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

18. Abstract P3-12-05: Serum levels of the active tamoxifen metabolite Z-4OHtam is predictive of long-term survival in luminal B subtype of breast cancer patients

Author

Helland, T, primary, Søiland, H, additional, Hustad, S, additional, Lash, TL, additional, Kvaløy, JT, additional, Renolen, A, additional, Borgen, E, additional, Bifulco, E, additional, Henne, N, additional, Lien, EA, additional, Mellgren, G, additional, Naume, B, additional, and Janssen, EA, additional

Published
2018
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19. Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using mr spectroscopy

Author

Euceda, L.R., Haukaas, T.H., Giskeodegard, G.F, Vettukattil, R., Engel, J, Silwal-Pandit, L., Lundgren, S., Borgen, E., Garred, O., Postma, G.J., Buydens, L.M.C., Borresen-Dale, A.L., Engebraaten, O., Bathen, T.F., Euceda, L.R., Haukaas, T.H., Giskeodegard, G.F, Vettukattil, R., Engel, J, Silwal-Pandit, L., Lundgren, S., Borgen, E., Garred, O., Postma, G.J., Buydens, L.M.C., Borresen-Dale, A.L., Engebraaten, O., and Bathen, T.F.

Abstract

Contains fulltext : 174413.pdf (publisher's version ) (Closed access)

Published
2017

20. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, T. (Thomas), Henne, N. (Nina), Bifulco, E. (Ersilia), Naume, B. (Bjorn), Borgen, E. (Elin), Kristensen, V.N. (Vessela N.), Kvaløy, J.T. (Jan T.), Lash, T.L. (Timothy L.), Alnæs, G.I.G. (Grethe I.G.), Schaik, R.H.N. (Ron) van, Janssen, E.A.M. (Emiel A.M.), Hustad, S. (Steinar), Lien, E.A. (Ernst A.), Mellgren, G. (Gunnar), Søiland, H. (Håvard), Helland, T. (Thomas), Henne, N. (Nina), Bifulco, E. (Ersilia), Naume, B. (Bjorn), Borgen, E. (Elin), Kristensen, V.N. (Vessela N.), Kvaløy, J.T. (Jan T.), Lash, T.L. (Timothy L.), Alnæs, G.I.G. (Grethe I.G.), Schaik, R.H.N. (Ron) van, Janssen, E.A.M. (Emiel A.M.), Hustad, S. (Steinar), Lien, E.A. (Ernst A.), Mellgren, G. (Gunnar), and Søiland, H. (Håvard)

Abstract

Background: Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement of concentrations of active tamoxifen metabolites in serum may be a more biological plausible and robust approach. We have investigated the association between CYP2D6 genotypes, serum concentrations of act

Published
2017
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21. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, T, Henne, N, Bifulco, E, Naume, B, Borgen, E, Kristensen, VN, Kvaloy, JT, Lash, TL, Alns, GIG, van Schaik, Ron, Janssen, EAM, Hustad, S, Lien, EA, Mellgren, G, Soiland, H, Helland, T, Henne, N, Bifulco, E, Naume, B, Borgen, E, Kristensen, VN, Kvaloy, JT, Lash, TL, Alns, GIG, van Schaik, Ron, Janssen, EAM, Hustad, S, Lien, EA, Mellgren, G, and Soiland, H

Published
2017

24. Abstract P6-13-01: Proteomic response in breast cancer treated with neoadjuvant chemotherapy with and without bevacizumab: Reverse phase protein array (RPPA) results from NeoAva - A randomized phase II study

Author

Haugen, MH, primary, Lindgjærde, OC, additional, Krohn, M, additional, Zhao, W, additional, Lindholm, EM, additional, Silwal-Pandit, L, additional, Borgen, E, additional, Garred, Ø, additional, Fangberget, A, additional, Holmen, MM, additional, Schlichting, E, additional, Skjerven, H, additional, Lundgren, S, additional, Wist, E, additional, Naume, B, additional, Mælandsmo, GM, additional, Lu, Y, additional, Børresen-Dale, A-L, additional, Mills, GB, additional, and Engebråten, O, additional

Published
2017
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25. Abstract S3-01: IMENEO: International MEta-analysis of circulating tumor cell detection in early breast cancer patients treated by NEOadjuvant chemotherapy

Author

Bidard, F-C, primary, Michiels, S, additional, Mueller, V, additional, Riethdorf, S, additional, Esserman, LJ, additional, Lucci, A, additional, Naume, B, additional, Horiguchi, J, additional, Gisbert-Criado, R, additional, Sleijfer, S, additional, Toi, M, additional, Garcia-Saenz, JA, additional, Hartkopf, A, additional, Generali, D, additional, Rothe, F, additional, Smerage, J, additional, Muinelo, L, additional, Stebbing, J, additional, Viens, P, additional, Magbanua, M, additional, Hall, CS, additional, Engebråtenm, O, additional, Takata, D, additional, Vidal-Martínez, J, additional, Onstenk, W, additional, Fujisawa, N, additional, Diaz-Rubio, E, additional, Taran, F-A, additional, Cappelletti, MR, additional, Ignatiadis, M, additional, Name, N, additional, Proudhon, C, additional, Wolf, D, additional, Bowman Bauldry, J, additional, Borgen, E, additional, Nagaoka, R, additional, Carañana, V, additional, Kraan, J, additional, Maestro, M, additional, Brucker, SY, additional, Weber, K, additional, Reyal, F, additional, Amara, D, additional, Gopalkrishna Karhade, M, additional, Ruud Mathiesen, R, additional, Tokiniwa, H, additional, Llombart-Cussac, A, additional, D'Hollander, K, additional, Cottu, P, additional, Park, JW, additional, Loibl, S, additional, Pierga, J-Y, additional, and Pantel, K, additional

Published
2017
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26. Abstract P2-05-16: Establishment of molecular profiling for individual treatment decisions in early breast cancer – Clinical impact of PAM50 and PAM50 risk of recurrence score after more than 16 years follow up

Author

Naume, B, primary, Borgen, E, additional, Falk, RS, additional, Ohnstad, HO, additional, Lien, TG, additional, Aaserud, M, additional, Sveli, MAT, additional, Kyte, JA, additional, Kristensen, V, additional, Geitvik, G, additional, Schlichting, E, additional, Wist, E, additional, Sørlie, T, additional, and Russnes, H, additional

Published
2017
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27. Single cell analysis of cancer cells using an improved RT-MLPA method has potential for cancer diagnosis and monitoring

Author

Kvastad, Linda, Werne Solnestam, Beata, Johansson, Elin, Nygren, A. O., Laddach, N., Sahlén, Pelin, Vickovic, Sanja, Bendigtsen, S. C., Aaserud, M., Floer, L., Borgen, E., Schwind, C., Himmelreich, R., Latta, D., Lundeberg, Joakim, Kvastad, Linda, Werne Solnestam, Beata, Johansson, Elin, Nygren, A. O., Laddach, N., Sahlén, Pelin, Vickovic, Sanja, Bendigtsen, S. C., Aaserud, M., Floer, L., Borgen, E., Schwind, C., Himmelreich, R., Latta, D., and Lundeberg, Joakim

Abstract

Single cell analysis techniques have great potential in the cancer genomics feld. The detection and characterization of circulating tumour cells are important for identifying metastatic disease at an early stage and monitoring it. This protocol is based on transcript profiling using Reverse Transcriptase Multiplex Ligation-dependent Probe Amplification (RT-MLPA), which is a specific method for simultaneous detection of multiple mRNA transcripts. Because of the small amount of (circulating) tumour cells, a pre-amplification reaction is performed after reverse transcription to generate a sufficient number of target molecules for the MLPA reaction. We designed a highly sensitive method for detecting and quantifying a panel of seven genes whose expression patterns are associated with breast cancer, and optimized the method for single cell analysis. For detection we used a fluorescence-dependent semi-quantitative method involving hybridization of unique barcodes to an array. We evaluated the method using three human breast cancer cell lines and identified specific gene expression profiles for each line. Furthermore, we applied the method to single cells and confirmed the heterogeneity of a cell population. Successful gene detection from cancer cells in human blood from metastatic breast cancer patients supports the use of RT-MLPA as a diagnostic tool for cancer genomics., Funding Details: Knut and Alice Wallenberg Foundation. QC 20161116

Published
2015
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28. LETTERS.

Author

HAYES, E. S., JACOB, FRANK M., ARADY, FRANK, CAFFREY, ANDREW A., PARTINGTON, A. W., PEFFER, J., ED, RICHARDSON, GEORGE B., BRUNKOW, A. H., LIDICKER, WILLIAM Z., CORRIGAN, EDWARD, NICHOLS, I. J., HALSTEAD JR., ALBERT, PHILLIPS, D. W., ODE, K. F., BORGEN, E. H., STILWELL JR., WM. E., KEAGLE, FOSTER, and LOFTUS, RUSSELL

Subjects
VETERANS with disabilities, BIRTH control laws, REFERENDUM
Published
1936

29. Single cell analysis of cancer cells using an improved RT-MLPA method has potential for cancer diagnosis and monitoring

Author

Kvastad, L., primary, Werne Solnestam, B., additional, Johansson, E., additional, Nygren, A. O., additional, Laddach, N., additional, Sahlén, P., additional, Vickovic, S., additional, Bendigtsen, Schirmer C., additional, Aaserud, M., additional, Floer, L., additional, Borgen, E., additional, Schwind, C., additional, Himmelreich, R., additional, Latta, D., additional, and Lundeberg, J., additional

Published
2015
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30. International study on inter-reader variability for circulating tumor cells in breast cancer.

Author

Ignatiadis, Michail, Riethdorf, Sabine, Bidard, François-Clément, Vaucher, Isabelle, Khazour, Mustapha, Rothé, Françoise, Metallo, Jessica, Rouas, Ghizlane, Payne, Rachel E, Coombes, Raoul Charles, Teufel, Ingrid, Andergassen, Ulrich, Apostolaki, Stella, Politaki, Eleni, Mavroudis, Dimitris, Bessi, Silvia, Pestrin, Marta, Di Leo, Angelo, Campion, Michael, Reinholz, Monica, Perez, Edith A, Piccart-Gebhart, Martine, Borgen, E, Naume, Bjorn, Jiménez, José Antonio, Aura, Claudia Monica, Zorzino, Laura, Cassatella, Maria Cristina, Sandri, Maria Teresa, Mostert, Bianca, Sleijfer, Stefan, Kraan, Jaco, Janni, Wolfgang, Fehm, Tanja, Rack, B, Terstappen, LWMM, Repollet, Madeline, Pierga, Jean-Yves, Miller, Craig, Sotiriou, Christos, Michiels, Stefan, Pantel, Klaus, Ignatiadis, Michail, Riethdorf, Sabine, Bidard, François-Clément, Vaucher, Isabelle, Khazour, Mustapha, Rothé, Françoise, Metallo, Jessica, Rouas, Ghizlane, Payne, Rachel E, Coombes, Raoul Charles, Teufel, Ingrid, Andergassen, Ulrich, Apostolaki, Stella, Politaki, Eleni, Mavroudis, Dimitris, Bessi, Silvia, Pestrin, Marta, Di Leo, Angelo, Campion, Michael, Reinholz, Monica, Perez, Edith A, Piccart-Gebhart, Martine, Borgen, E, Naume, Bjorn, Jiménez, José Antonio, Aura, Claudia Monica, Zorzino, Laura, Cassatella, Maria Cristina, Sandri, Maria Teresa, Mostert, Bianca, Sleijfer, Stefan, Kraan, Jaco, Janni, Wolfgang, Fehm, Tanja, Rack, B, Terstappen, LWMM, Repollet, Madeline, Pierga, Jean-Yves, Miller, Craig, Sotiriou, Christos, Michiels, Stefan, and Pantel, Klaus

Abstract

Circulating tumor cells (CTCs) have been studied in breast cancer with the CellSearch(R) system. Given the low CTC counts in non-metastatic breast cancer, it is important to evaluate the inter-reader agreement., JOURNAL ARTICLE, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2014

31. International study on inter-reader variability for circulating tumor cells in breast cancer

Author

Ignatiadis, M, Riethdorf, S, Bidard, FC, Vaucher, I, Khazour, M, Roth, F, Metallo, J, Rouas, G, Payne, RE, Coombes, RC, Teufel, I, Andergassen, U, Apostolaki, S, Politaki, E, Mavroudis, D, Bessi, S, Pestrin, M, De Leo, A, Campion, M, Reinholz, M, Perez, E, Piccart, M, Borgen, E, Naume, B, Jimenez, J, Aura, CM, Zorzino, L, Cassatella, MC, Sandri, MT, Mostert, Bianca, Sleijfer, Stefan, Kraan, Jaco, Janni, W, Fehm, T, Rack, B, Terstappen, L, Repollet, M, Pierga, JY, Miller, C, Sotiriou, C, Michiels, S, Pantel, K, Ignatiadis, M, Riethdorf, S, Bidard, FC, Vaucher, I, Khazour, M, Roth, F, Metallo, J, Rouas, G, Payne, RE, Coombes, RC, Teufel, I, Andergassen, U, Apostolaki, S, Politaki, E, Mavroudis, D, Bessi, S, Pestrin, M, De Leo, A, Campion, M, Reinholz, M, Perez, E, Piccart, M, Borgen, E, Naume, B, Jimenez, J, Aura, CM, Zorzino, L, Cassatella, MC, Sandri, MT, Mostert, Bianca, Sleijfer, Stefan, Kraan, Jaco, Janni, W, Fehm, T, Rack, B, Terstappen, L, Repollet, M, Pierga, JY, Miller, C, Sotiriou, C, Michiels, S, and Pantel, K

Abstract

Introduction: Circulating tumor cells (CTCs) have been studied in breast cancer with the CellSearch (R) system. Given the low CTC counts in non-metastatic breast cancer, it is important to evaluate the inter-reader agreement. Methods: CellSearch (R) images (N = 272) of either CTCs or white blood cells or artifacts from 109 non-metastatic (M0) and 22 metastatic (M1) breast cancer patients from reported studies were sent to 22 readers from 15 academic laboratories and 8 readers from two Veridex laboratories. Each image was scored as No CTC vs CTC HER2-vs CTC HER2+. The 8 Veridex readers were summarized to a Veridex Consensus (VC) to compare each academic reader using % agreement and kappa (.) statistics. Agreement was compared according to disease stage and CTC counts using the Wilcoxon signed rank test. Results: For CTC definition (No CTC vs CTC), the median agreement between academic readers and VC was 92% (range 69 to 97%) with a median. of 0.83 (range 0.37 to 0.93). Lower agreement was observed in images from M0 (median 91%, range 70 to 96%) compared to M1 (median 98%, range 64 to 100%) patients (P < 0.001) and from M0 and < 3CTCs (median 87%, range 66 to 95%) compared to M0 and >= 3CTCs samples (median 95%, range 77 to 99%), (P < 0.001). For CTC HER2 expression (HER2-vs HER2+), the median agreement was 87% (range 51 to 95%) with a median. of 0.74 (range 0.25 to 0.90). Conclusions: The inter-reader agreement for CTC definition was high. Reduced agreement was observed in M0 patients with low CTC counts. Continuous training and independent image review are required.

Published
2014

34. Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c

Author

Nygren, M K, primary, Tekle, C, additional, Ingebrigtsen, V A, additional, Mäkelä, R, additional, Krohn, M, additional, Aure, M R, additional, Nunes-Xavier, C E, additional, Perälä, M, additional, Tramm, T, additional, Alsner, J, additional, Overgaard, J, additional, Nesland, J M, additional, Borgen, E, additional, Børresen-Dale, A-L, additional, Fodstad, Ø, additional, Sahlberg, K K, additional, and Leivonen, S-K, additional

Published
2014
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35. Lab-on-chip tracing circulating tumour cells

Author

Lagae, L., Liu, C. X., Latta, D., Henry, O., O'Sullivan, C., Roeser, T., Lundeberg, Joakim, Kvastad, Linda, Riley, I., Borgen, E., Lagae, L., Liu, C. X., Latta, D., Henry, O., O'Sullivan, C., Roeser, T., Lundeberg, Joakim, Kvastad, Linda, Riley, I., and Borgen, E.

Abstract

QC 20131210

Published
2013

37. Abstract P4-14-02: Molecular response in breast cancer tumors treated with neoadjuvant chemotherapy with and without bevacizumab: Results from NeoAva - A randomized phase II study

Author

Engebraaten, O, primary, Vaske, C, additional, Krohn, M, additional, Silwal-Pandit, L, additional, Moen Vollan, HK, additional, Møller, EK, additional, Nord, S, additional, Fleischer, T, additional, Borgen, E, additional, Edvardsen, H, additional, Garred, Ø, additional, Fangberget, A, additional, Holmen, MM, additional, Schlichting, E, additional, Skjerven, H, additional, Lundgren, S, additional, Wist, E, additional, Naume, B, additional, Børresen-Dale, A-L, additional, and Kristensen, VN, additional

Published
2013
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38. Abstract P4-14-01: A time course study of genomic instability in breast cancer patients receiving neoadjuvant therapy with or without bevacizumab

Author

Møller, EK, primary, Moen Vollan, HK, additional, Nord, S, additional, von der Lippe Gythfeldt, H, additional, Edvardsen, H, additional, Silwal-Pandit, L, additional, Krohn, M, additional, Fleischer, T, additional, Schlitchting, E, additional, Borgen, E, additional, Garred, Ø, additional, Fangberget, A, additional, Holmen, MM, additional, Skjerven, H, additional, Lundgren, S, additional, Wist, E, additional, Naume, B, additional, Børresen-Dale, A-L, additional, Kristensen, VN, additional, and Engebraaten, O, additional

Published
2013
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40. Circulating Tumor Cells (CTCs) Detection and HER2 Profiling by CellSearch® in Non-Metastatic Breast Cancer: An International Ring Study To Assess Inter-Reader Variability

Author

Ignatiadis, Michail, Pierga, Jean-Yves, Campion, M., Fehm, Tanja, Payne, R., Rack, B, Mavroudis, Dimitris, Riethdorf, Sabine, Rothé, Françoise, Bessi, Silvia, Aura, Claudia, Sandri, Maria Teresa, Borgen, E, Kraan, Jaco, Terstappen, LWMM, Piccart-Gebhart, Martine, Sotiriou, Christos, Michiels, Stefan, Pantel, Klaus, Ignatiadis, Michail, Pierga, Jean-Yves, Campion, M., Fehm, Tanja, Payne, R., Rack, B, Mavroudis, Dimitris, Riethdorf, Sabine, Rothé, Françoise, Bessi, Silvia, Aura, Claudia, Sandri, Maria Teresa, Borgen, E, Kraan, Jaco, Terstappen, LWMM, Piccart-Gebhart, Martine, Sotiriou, Christos, Michiels, Stefan, and Pantel, Klaus

Abstract

P4-07-14Poster Session 4: Detection and Diagnosis – Pathology: Circulating Tumor Cells, info:eu-repo/semantics/published

Published
2011

41. Circulating Tumor Cells (CTCs) Detection and HER2 Profiling by CellSearch® in Non-Metastatic Breast Cancer: An International Ring Study To Assess Inter-Reader Variability.

Author

San Antonio Breast Cancer Symposium-SABCS (December 5-10, 2011: San Antonio, Tx, USA), Ignatiadis, Michail, Pierga, Jean-Yves, Campion, M., Fehm, Tanja, Payne, R., Rack, B, Mavroudis, Dimitris, Riethdorf, Sabine, Rothé, Françoise, Bessi, Silvia, Aura, Claudia Monica, Sandri, Maria Teresa, Borgen, E, Kraan, Jaco, Terstappen, LWMM, Piccart-Gebhart, Martine, Sotiriou, Christos, Michiels, Stefan, Pantel, Klaus, San Antonio Breast Cancer Symposium-SABCS (December 5-10, 2011: San Antonio, Tx, USA), Ignatiadis, Michail, Pierga, Jean-Yves, Campion, M., Fehm, Tanja, Payne, R., Rack, B, Mavroudis, Dimitris, Riethdorf, Sabine, Rothé, Françoise, Bessi, Silvia, Aura, Claudia Monica, Sandri, Maria Teresa, Borgen, E, Kraan, Jaco, Terstappen, LWMM, Piccart-Gebhart, Martine, Sotiriou, Christos, Michiels, Stefan, and Pantel, Klaus

Abstract

Poster Session 4: Detection and Diagnosis – Pathology: Circulating Tumor Cells, info:eu-repo/semantics/nonPublished

Published
2011

45. P4-07-14: Circulating Tumor Cells (CTCs) Detection and HER2 Profiling by CellSearch® in Non-Metastatic Breast Cancer: An International Ring Study To Assess Inter-Reader Variability.

Author

Ignatiadis, M, primary, Pierga, J-Y, additional, Campion, M, additional, Fehm, T, additional, Payne, R, additional, Rack, B, additional, Mavroudis, D, additional, Riethdorf, S, additional, Rothe, F, additional, Bessi, S, additional, Aura, CM, additional, Sandri, MT, additional, Borgen, E, additional, Kraan, J, additional, Terstappen, LWMM, additional, Piccart, M, additional, Sotiriou, C, additional, Michiels, S, additional, and Pantel, K, additional

Published
2011
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46. P5-18-07: Presence of Disseminated Tumor Cells after Adjuvant Chemotherapy in Breast Cancer and Disseminated Tumor Cells Monitoring during Secondary Adjuvant Treatment.

Author

Synnestvedt, M, primary, Borgen, E, additional, Wist, E, additional, Wiedswang, G, additional, Weyde, K, additional, Risberg, T, additional, Kersten, C, additional, Mjaaland, I, additional, Vindi, L, additional, Schirmer, CB, additional, Nesland, JM, additional, and Naume, B, additional

Published
2011
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