1. The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes
- Author
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van de Vijver, David, Wensing, Annemarie M.J., Angarano, Gioacchino, Asjo, Birgitta, Balotta, Claudia, De Luca, Andrea, Derdelinckx, Inge, Maljkovic, Irina, de Mendoza, Carmen, Meyer, Laurence, Nielsen, Claus, de Coul, Eline L.M. Op, Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stockl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, Vandamme, Anne-Mieke, Laethem, Kristel Van, Violin, Michela, Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, Boucher, Charles A.B.X, Grossman, Zehava, Hamouda, Osamah, Hulzokis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kucherer, Claudia, Leitner, Thomas, Loveday, Clive, and MacRae, Eilidh
- Subjects
HIV patients -- Care and treatment ,HIV patients -- Genetic aspects ,HIV infection -- Care and treatment ,HIV infection -- Genetic aspects ,Drug resistance -- Genetic aspects ,Health - Abstract
The genetic barrier between subtypes are compared using some 2000 HIV-1 sequences (>600 of non-B subtype) isolated from anti-retroviral-naive patients in Europe. Based on the calculated genetic barrier, the rate of drug resistance development may be similar for different HIV-1 subtypes.
- Published
- 2006