Search

Your search keyword '"Bruijn, L."' showing total 157 results
Start Over Author "Bruijn, L."

Refine your results

more »

more »

more »

more »
157 results on '"Bruijn, L."'

1. Combining topic modelling and citation network analysis to study case law from the European Court on Human Rights on the right to respect for private and family life

Author

Mohammadi, M., Bruijn, L. M., Wieling, M., and Vols, M.

Subjects
Computer Science - Information Retrieval, Computer Science - Computation and Language, Computer Science - Digital Libraries, Computer Science - Machine Learning
Abstract

As legal case law databases such as HUDOC continue to grow rapidly, it has become essential for legal researchers to find efficient methods to handle such large-scale data sets. Such case law databases usually consist of the textual content of cases together with the citations between them. This paper focuses on case law from the European Court of Human Rights on Article 8 of the European Convention of Human Rights, the right to respect private and family life, home and correspondence. In this study, we demonstrate and compare the potential of topic modelling and citation network to find and organize case law on Article 8 based on their general themes and citation patterns, respectively. Additionally, we explore whether combining these two techniques leads to better results compared to the application of only one of the methods. We evaluate the effectiveness of the combined method on a unique manually collected and annotated dataset of Aricle 8 case law on evictions. The results of our experiments show that our combined (text and citation-based) approach provides the best results in finding and grouping case law, providing scholars with an effective way to extract and analyse relevant cases on a specific issue.

Published
2024

5. Plantaardige Genetische Bronnen : Brede gewascollecties van wereldwijde betekenis

Author

Kierkels, T., Bruijn, L. de, Hintum, T. van, Brink, M., Treuren, R. van, Hendriks, V., Kierkels, T., Bruijn, L. de, Hintum, T. van, Brink, M., Treuren, R. van, and Hendriks, V.

Abstract

Genetische diversiteit is van groot belang voor een toekomstbestendige land- en tuinbouw. Het Centrum voor Genetische Bronnen Nederland (CGN) heeft een omvangrijke collectie rassen en populaties van cultuurgewassen en hun wilde verwanten in zijn genenbank. Het streven is om zoveel mogelijk gevarieerde eigenschappen te verzamelen die als basis kunnen dienen voor nieuwe rassen. Deze collectie is vrij te gebruiken door veredelaars, onderzoekers en experts uit binnen- en buitenland.

Published
2024

10. Dienend leiderschap bij integraal werkende multidisciplinaire teams binnen F-35 squadrons

Author

Bruijn, L. de and Bruijn, L. de

Abstract

NLDA Bachelor Eindstudie, Middels dit onderzoek is getracht inzicht te verkrijgen in hoeverre dienend leiderschap een effectieve leiderschapsstijl zou kunnen zijn voor het aansturen van de integraal werkende multidisciplinaire teams, die als gevolg van de komst van de F-35 hun intrede hebben gedaan. Om dit inzicht te verkrijgen is de hoofdvraag van het onderzoek als volgt: In hoeverre en op welke wijze kan dienend leiderschap een effectieve leiderschapsstijl zijn voor de aansturing van integraal werkende multidisciplinaire teams binnen F-35 squadrons? Om hier antwoord op te geven is eerst een theoretisch onderzoek gedaan naar leiderschap, toegespitst op dienend leiderschap. Daarbij is ingegaan op deze leiderschapsstijl in een context waar gewerkt wordt met experts, een militaire en daarna informatierijke context. Deze factoren zijn immers relevant gebleken. Vervolgens is empirisch onderzoek uitgevoerd door het afnemen van interviews binnen de F-35 squadrons. Uit het onderzoek is gebleken dat dienend leiderschap een effectieve leiderschapsstijl blijkt te zijn om toe te passen voor de aansturing van integraal werkende teams binnen F-35 squadrons. Dienend leiderschap draagt bij aan de ontwikkeling van personeel in een informatierijke omgeving waarin flexibiliteit en vooruitgang vereisten zijn. Daarbij is het een geschikte stijl om personeel vertrouwen te geven, gemotiveerd te houden, betrokken te houden en te ontwikkelen. Uit interviews met respondenten is gebleken dat hetgeen zij verwachten van een leidinggevende, sterk overeenkomt met de karakteristieken van dienend leiderschap uit de theorie. Daarbij past het in de informatierijke, complexe context van een F-35 squadron waarbinnen veel experts werkzaam zijn. Er kan dus geconcludeerd worden dat dienend leiderschap een effectieve leiderschapsstijl kan zijn om toe te passen bij de aansturing van integraal werkende multidisciplinaire teams binnen F-35 squadrons. In de toekomst zou verder onderzoek naar de toepassing van deze leiderschapsstijl aa

Published
2023

11. Hesselweg 2-2a te Megchelen. Gemeente Oude IJsselstreek. Bureau- en inventariserend veldonderzoek

Author

Bruijn, L., Stevens, FRANK, and Synthegra Archeologie

Subjects
Archaeology, Nieuwe tijd: 1500 - heden (NT), Economie, onbepaald (EX), Paleolithicum laat B: 18000 C14 -8800 vC (PALEOLB), Laat-Paleolithicum t/m Nieuwe tijd
Abstract

Synthegra B.V. heeft in opdracht een archeologisch bureauonderzoek in combinatie met een verkennend booronderzoek uitgevoerd op een terrein aan de Hesselweg 2/2a te Megchelen. Het onderzoek wordt begrensd door weg aan de noordkant en huizen aan weerskanten. De aanleiding voor het onderzoek is de realisatie van woningen. De oppervlakte van de toekomstige bodemverstoring bedraagt 1.600 m2 met een diepte van ca. 1 meter beneden maaiveld. Aangezien het plangebied circa 1.600 m2 groot is, zijn verspreid over het plangebied in totaal 6 boringen gezet. Voor zover de terreinomstandigheden (bebouwing, verhardingen, begroeiing etc.) het toelieten. Er is geboord met een Edelmanboor met een diameter van 7 cm en een gutsboor met een diameter van 3 cm. De boringen zijn uitgevoerd tot minimaal 25 cm in de C-horizont, of in specifieke afzettingen, of tot de verstoringsdiepte. De boringen zijn lithologisch beschreven conform de NEN 5104 en bodemkundig geïnterpreteerd. Het natuurlijke bodemtype is verstoord tot gemiddeld 50 centimeter beneden het maaiveld. Hieronder is nog een intact bodemprofiel aanwezig. Het betreft een ooivaaggrond die gekenmerkt wordt door een B-horizont die wel tot 1 meter dik kan worden.

Published
2022
Full Text
View/download PDF

13. Over vermeende wetshistorische rechtsvinding en selectieve interpretatie

Author

Michelle Bruijn, L., Joep Koornstra, Berend Roorda, Jon Schilder, Jan Brouwer, Constitutional and Administrative Law, Kooijmans Institute, Fundamental Rights, Regulation and Responsible Government, and Public Trust and Public Law

Subjects
SDG 16 - Peace, SDG 16 - Peace, Justice and Strong Institutions, Justice and Strong Institutions
Abstract

De rechter moet volgens de wet rechtspreken. Aan de wet liggen immersdemocratisch tot stand gekomen keuzes ten grondslag. Is de wetonduidelijk, dan kan de bedoeling van de wetgever worden achterhaald in detotstandkomingsgeschiedenis. Met behulp van een selectief gebruik van deparlementaire geschiedenis legitimeert de rechter evenwel ook regelmatig doorhemzelf gewenste maatschappelijke uitkomsten. Die praktijk is niet zonderbedenkingen, zeker niet wanneer daardoor individuele vrijheidsrechten in deverdrukking komen.

Published
2020

19. Properties and performance of the prototype instrument for the Pierre Auger Observatory

Author

Abraham, J., Aglietta, M., Aguirre, I.C., Albrow, M., Allard, D., Allekotte, I., Allison, P., Alvarez Muñiz, J., do Amaral, M.G., Ambrosio, M., Anchordoqui, L., Andrews, R., Anguiano, M., dos Anjos, J.C., Aramo, C., Argiro, S., Arisaka, K., Arteaga, J.C., Atulugama, S., Ave, M., Avila, G., Baggio, R., Bai, X., Barbosa, A.F., Barbosa, H.M.J., Barnhill, D., Barroso, S.L.C., Bauleo, P., Beatty, J., Beau, T., Becker, K.-H., Bellido, J.A., Bello, P., Bergmann, T., Berman, E., Bertou, X., Biermann, P., Billoir, P., Biral, R., Bluemer, H., Bohacova, M., Bollmann, E., Bonifazi, C., Boratav, M., Boselli, A., Brack, J., Brunet, J.-M., Bui-Duc, H., Cabrera, V., Camin, D.V., Capdevielle, J.-N., Carreño, A., Cartiglia, N., Caruso, R., de Carvalho, L.A., Casanova, S., Casimiro, E., Castellina, A., Castro, J., Cattaneo, P.W., Cazon, L., Cester, R., Chávez, N., Cheam, D., Chiavassa, A., Chinellato, J.A., Chiosso, M., Chou, A., Chye, J., Cillis, A., Civit, B., Claes, D., Clark, P.D.J., Clay, R.W., Cohen, F., Cordero, A., Cordier, A., Cormier, E., Cotzomi, J., Cotti, U., Coutu, S., Covault, C.E., Creusot, A., Cronin, J.W., Cuautle, M., Dagoret-Campagne, S., Dang-Quang, T., Da Silva, P., Darling, J., Darriulat, P., Daumiller, K., Dawson, B.R., de Bruijn, L., De Capoa, A., de Oliveira, M.A.L., de Souza, V., Della Selva, A., Deligny, O., Diaz, J.C., Dobrigkeit, C., D'Olivo, J.C., Dorofeev, A., Dova, M.T., Dye, A., DuVernois, M.A., Engel, R., Epele, L.N., Eschstruth, P., Escobar, C.O., Etchegoyen, A., Facal San Luis, P., Fauth, A.C., Fazzini, N., Fernández, A., Ferrero, A.M.J., Fick, B., Filevich, A., Filipčič, A., Fonte, R., Fulgione, W., Gámez, E., Garcia, B., Garcia, C.A., Geenen, H., Gemmeke, H., Germain-Renaud, C., Ghia, P.L., Gibbs, K., Giller, M., Gitto, J., Glass, H., Gómez Berisso, M., Gomez Vitale, P.F., González, J., Gora, D., Goodwin, A., Gouffon, P., Grassi, V., Grillo, A.F., Grunfeld, C., Grygar, J., Guarino, F., Guedes, G., Guerard, C., Gumbsheimer, R., Harton, J.L., Hasenbalg, F., Heck, D., Hernández, J.M., Hoffer, D., Hojvat, C., Homola, P., Horvat, M., Hrabovsky, M., Insolia, A., Jaminion, S., Jerónimo, Y., Jiang, L., Kaducak, M., Kampert, K.-H., Keilhauer, B., Kemp, E., Klages, H., Kleifges, M., Kleinfeller, J., Knapp, J., Kopmann, A., Kunka, N., Kutschera, M., Lachaud, C., Lapolla, M., Letessier-Selvon, A., Lhenry-Yvon, I., Lloyd-Evans, J., López, R., Lopez Aguera, A., Lucano, M., Luna, R., Ma, Y., Manceñido, M.E., Manfredi, P.F., Manhaes, L., Mantsch, P., Mariazzi, A.G., Markus, M.J., Martin, G., Martineau, O., Martinez, J., Martinez, N., Martı́nez, O., Mathes, H.-J., Matthews, J.A.J., Matthews, J., Matthiae, G., Marques, E., Matussek, P., Maurin, G., Maurizio, D., Mazur, P., McCauley, T., McEwen, M., McNeil, R.R., Medina, C., Medina, M.C., Medina-Tanco, G., Melo, D., Melocchi, M., Menichetti, E., Menshikov, A., Meyer, F., Meyhandan, R., Meza, J.C., Miele, G., Miller, W., Mohammed, M., Monnier-Ragaigne, D., Morello, C., Moreno, E., Mostafa, M., Mussa, R., Nassini, H., Navarra, G., Nellen, L., Nerling, F., Newman-Holmes, C., Nicotra, D., Nigro, S., Nitz, D., Nogima, H., Nosek, D., Nuñez, M., Ohnuki, T., Olinto, A., Ostaptchenko, S., Palatka, M., Parente, G., Parizot, E., Pasaye, E.H., Pastrone, N., Patel, M., Paul, T., Pedraza, I., Pekala, J., Pelayo, R., Pepe, I.M., Pérez-Lorenzana, A., Perrone, L., Peshman, N., Petrera, S., Petrinca, P., Pham-Ngoc, D., Pham-Trung, P., Pierog, T., Pisanti, O., Playez, N., Ponce, E., Porter, T.A., Prado Junior, L., Privitera, P., Prouza, M., Pryke, C.L., Rafert, J.B., Raia, G., Ranchon, S., Ratti, L., Ravignani, D., Re, V., Reis, H.C., Reucroft, S., Revenue, B., Richter, M., Ridky, J., Risi, A., Risse, M., Rizi, V., Roberts, M.D., Robledo, C., Rodriguez, G., Rodriquez, J., Rodriquez Martino, J., Román, S., Rosa, L., Roth, M., Rovero, A.C., Salazar, H., Salina, G., Sanchez, F., Santander, M., dos Santos, L.G., Sato, R., Schovanek, P., Scherini, V., Sciutto, S.J., Sequeiros-Haddad, G., Shellard, R.C., Shibuya, E., Siguas, F.V., Slater, W., Smetniansky-De Grande, N., Smith, K., Snow, G.R., Sommers, P., Song, C., Spinka, H., Suarez, F., Suomijärvi, T., Supanitsky, D., Swain, J., Szadkowski, Z., Tamashiro, A., Thornton, G.J., Thouw, T., Ticona, R., Tkaczyk, W., Todero Peixoto, C.J., Tripathi, A., Tristram, G., Trombley, M., Tscherniakhovski, D., Tuckey, P., Tunnicliffe, V., Urban, M., Uribe Estrada, C., Valdés, J.F., Vargas, A., Vargas, C., Vazquez, R., Veberič, D., Veiga, A., Velarde, A., Vernotte, F., Verzi, V., Videla, M., Vigorito, C., Villaseñor, L.M., Vlcek, M., Voyvodic, L., Vo-Van, T., Waldenmaier, T., Walker, P., Warner, D., Watson, A.A., Wiebusch, Ch., Wieczorek, G., Wilczynska, B., Wilczynski, H., Wild, N.R., Yamamoto, T., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhang, C., and Zhu, Q.

Published
2004
Full Text
View/download PDF

20. Treatment of posttraumatic stress disorder following childbirth

Author

Bruijn, L. (Lisa) de, A. I. Stramrood, C. (Claire), Lambregtse-van den Berg, M.P. (Mijke), Rius Ottenheim, N. (Nathaly), Bruijn, L. (Lisa) de, A. I. Stramrood, C. (Claire), Lambregtse-van den Berg, M.P. (Mijke), and Rius Ottenheim, N. (Nathaly)

Abstract

Aim: The aim of this systematic review is to give an overview of the literature on treatment options for posttraumatic stress disorder (PTSD) following childbirth and to assess their efficacy. Method: PubMed, Embase, Web of Science, Cochrane and PsycINFO were searched using “PTSD”, “childbirth” and “therapy” as terms for studies in English language published between 2000 and 2017. Additional studies were identified by checking reference lists. Studies were included when presence of PTSD was confirmed prior to treatment and childbirth was the traumatic event focused on. All studies were reviewed on sample size, study design, used instruments, sample characteristics, type of treatment and the result of treatment regarding PTSD (symptoms). Results: Six studies met the inclusion criteria. One study on debriefing, three studies on cognitive behavioral therapy (CBT) and two studies on eye movement desensitization and reprocessing (EMDR) were identified. Both EMDR and CBT appear to be promising therapies for PTSD following childbirth. Debriefing seems to be beneficial when women request it themselves. Conclusions: EMDR and CBT seem to be effective as therapy for PTSD following childbirth. However, evidence is still limi

Published
2019
Full Text
View/download PDF

23. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

Author

Nicolas, A, Kenna, K, Renton, A, Ticozzi, N, Faghri, F, Chia, R, Dominov, J, Kenna, B, Nalls, M, Keagle, P, Rivera, A, van Rheenen, W, Murphy, N, van Vugt, J, Geiger, J, van der Spek, R, Pliner, H, Shankaracharya, N, Smith, B, Marangi, G, Topp, S, Abramzon, Y, Gkazi, A, Eicher, J, Kenna, A, Logullo, F, Simone, I, Logroscino, G, Salvi, F, Bartolomei, I, Borghero, G, Murru, M, Costantino, E, Pani, C, Puddu, R, Caredda, C, Piras, V, Tranquilli, S, Cuccu, S, Corongiu, D, Melis, M, Milia, A, Marrosu, F, Marrosu, M, Floris, G, Cannas, A, Capasso, M, Caponnetto, C, Mancardi, G, Origone, P, Mandich, P, Conforti, F, Cavallaro, S, Mora, G, Marinou, K, Sideri, R, Penco, S, Mosca, L, Lunetta, C, Pinter, G, Corbo, M, Riva, N, Carrera, P, Volanti, P, Mandrioli, J, Fini, N, Fasano, A, Tremolizzo, L, Arosio, A, Ferrarese, C, Trojsi, F, Tedeschi, G, Monsurrò, M, Piccirillo, G, Femiano, C, Ticca, A, Ortu, E, La Bella, V, Spataro, R, Colletti, T, Sabatelli, M, Zollino, M, Conte, A, Luigetti, M, Lattante, S, Santarelli, M, Petrucci, A, Pugliatti, M, Pirisi, A, Parish, L, Occhineri, P, Giannini, F, Battistini, S, Ricci, C, Benigni, M, Cau, T, Loi, D, Calvo, A, Moglia, C, Brunetti, M, Barberis, M, Restagno, G, Casale, F, Marrali, G, Fuda, G, Ossola, I, Cammarosano, S, Canosa, A, Ilardi, A, Manera, U, Grassano, M, Tanel, R, Pisano, F, Mazzini, L, Messina, S, D'Alfonso, S, Corrado, L, Ferrucci, L, Harms, M, Goldstein, D, Shneider, N, Goutman, S, Simmons, Z, Miller, T, Chandran, S, Pal, S, Manousakis, G, Appel, S, Simpson, E, Wang, L, Baloh, R, Gibson, S, Bedlack, R, Lacomis, D, Sareen, D, Sherman, A, Bruijn, L, Penny, M, Moreno, C, Kamalakaran, S, Allen, A, Boone, B, Brown, R, Carulli, J, Chesi, A, Chung, W, Cirulli, E, Cooper, G, Couthouis, J, Day-Williams, A, Dion, P, Gitler, A, Glass, J, Han, Y, Harris, T, Hayes, S, Jones, A, Keebler, J, Krueger, B, Lasseigne, B, Levy, S, Lu, Y, Maniatis, T, McKenna-Yasek, D, Myers, R, Petrovski, S, Pulst, S, Raphael, A, Ravits, J, Ren, Z, Rouleau, G, Sapp, P, Sims, K, Staropoli, J, Waite, L, Wang, Q, Wimbish, J, Xin, W, Phatnani, H, Kwan, J, Broach, J, Arcila-Londono, X, Lee, E, Van Deerlin, V, Fraenkel, E, Ostrow, L, Baas, F, Zaitlen, N, Berry, J, Malaspina, A, Fratta, P, Cox, G, Thompson, L, Finkbeiner, S, Dardiotis, E, Hornstein, E, Macgowan, D, Heiman-Patterson, T, Hammell, M, Patsopoulos, N, Dubnau, J, Nath, A, Musunuri, R, Evani, U, Abhyankar, A, Zody, M, Kaye, J, Wyman, S, Lenail, A, Lima, L, Rothstein, J, Svendsen, C, Van Eyk, J, Maragakis, N, Kolb, S, Cudkowicz, M, Baxi, E, Benatar, M, Taylor, J, Wu, G, Rampersaud, E, Wuu, J, Rademakers, R, Züchner, S, Schule, R, Mccauley, J, Hussain, S, Cooley, A, Wallace, M, Clayman, C, Barohn, R, Statland, J, Swenson, A, Jackson, C, Trivedi, J, Khan, S, Katz, J, Jenkins, L, Burns, T, Gwathmey, K, Caress, J, Mcmillan, C, Elman, L, Pioro, E, Heckmann, J, So, Y, Walk, D, Maiser, S, Zhang, J, Silani, V, Gellera, C, Ratti, A, Taroni, F, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, G, Sorarù, G, Cereda, C, De Marchi, F, Corti, S, Ceroni, M, Siciliano, G, Filosto, M, Inghilleri, M, Peverelli, S, Colombrita, C, Poletti, B, Maderna, L, Del Bo, R, Gagliardi, S, Querin, G, Bertolin, C, Pensato, V, Castellotti, B, Camu, W, Mouzat, K, Lumbroso, S, Corcia, P, Meininger, V, Besson, G, Lagrange, E, Clavelou, P, Guy, N, Couratier, P, Vourch, P, Danel, V, Bernard, E, Lemasson, G, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, R, Sidle, K, Hardy, J, Singleton, A, Johnson, J, Arepalli, S, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, de Belleroche, J, ten Asbroek, A, Muñoz-Blanco, J, Hernandez, D, Ding, J, Gibbs, J, Scholz, S, Floeter, M, Campbell, R, Landi, F, Bowser, R, Kirby, J, Pamphlett, R, Gerhard, G, Dunckley, T, Brady, C, Kowall, N, Troncoso, J, Le Ber, I, Kamel, F, Van Den Bosch, L, Strom, T, Meitinger, T, Shatunov, A, Van Eijk, K, de Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, Mclaughlin, R, Van Es, M, Weber, M, Boylan, K, Van Blitterswijk, M, Morrison, K, Basak, A, Mora, J, Drory, V, Shaw, P, Turner, M, Talbot, K, Hardiman, O, Williams, K, Fifita, J, Nicholson, G, Blair, I, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Al Kheifat, A, Andersen, P, Chio, A, Cooper-Knock, J, Dekker, A, Redondo, A, Gotkine, M, Hide, W, Iacoangeli, A, Kiernan, M, Landers, J, Mill, J, Neto, M, Pardina, J, Newhouse, S, Pinto, S, Pulit, S, Robberecht, W, Shaw, C, Sproviero, W, Tazelaar, G, van Damme, P, van den Berg, L, van Eijk, K, van Es, M, Veldink, J, Zatz, M, Bauer, D, Twine, N, Rogaeva, E, Zinman, L, Brice, A, Feldman, E, Ludolph, A, Weishaupt, J, Trojanowski, J, Stone, D, Tienari, P, Chiò, A, Traynor, B, Nicolas, Aude, Kenna, Kevin P., Renton, Alan E., Ticozzi, Nicola, Faghri, Faraz, Chia, Ruth, Dominov, Janice A., Kenna, Brendan J., Nalls, Mike A., Keagle, Pamela, Rivera, Alberto M., van Rheenen, Wouter, Murphy, Natalie A., van Vugt, Joke J. F. A., Geiger, Joshua T., van der Spek, Rick, Pliner, Hannah A., Shankaracharya, null, Smith, Bradley N., Marangi, Giuseppe, Topp, Simon D., Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D., Kenna, Aoife, Logullo, Francesco O., Simone, Isabella, Logroscino, Giancarlo, Salvi, Fabrizio, Bartolomei, Ilaria, Borghero, Giuseppe, Murru, Maria Rita, Costantino, Emanuela, Pani, Carla, Puddu, Roberta, Caredda, Carla, Piras, Valeria, Tranquilli, Stefania, Cuccu, Stefania, Corongiu, Daniela, Melis, Maurizio, Milia, Antonio, Marrosu, Francesco, Marrosu, Maria Giovanna, Floris, Gianluca, Cannas, Antonino, Capasso, Margherita, Caponnetto, Claudia, Mancardi, Gianluigi, Origone, Paola, Mandich, Paola, Conforti, Francesca L., Cavallaro, Sebastiano, Mora, Gabriele, Marinou, Kalliopi, Sideri, Riccardo, Penco, Silvana, Mosca, Lorena, Lunetta, Christian, Pinter, Giuseppe Lauria, Corbo, Massimo, Riva, Nilo, Carrera, Paola, Volanti, Paolo, Mandrioli, Jessica, Fini, Nicola, Fasano, Antonio, Tremolizzo, Lucio, Arosio, Alessandro, Ferrarese, Carlo, Trojsi, Francesca, Tedeschi, Gioacchino, Monsurrò, Maria Rosaria, Piccirillo, Giovanni, Femiano, Cinzia, Ticca, Anna, Ortu, Enzo, La Bella, Vincenzo, Spataro, Rossella, Colletti, Tiziana, Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, Marialuisa, Petrucci, Antonio, Pugliatti, Maura, Pirisi, Angelo, Parish, Leslie D., Occhineri, Patrizia, Giannini, Fabio, Battistini, Stefania, Ricci, Claudia, Benigni, Michele, Cau, Tea B., Loi, Daniela, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Barberis, Marco, Restagno, Gabriella, Casale, Federico, Marrali, Giuseppe, Fuda, Giuseppe, Ossola, Irene, Cammarosano, Stefania, Canosa, Antonio, Ilardi, Antonio, Manera, Umberto, Grassano, Maurizio, Tanel, Raffaella, Pisano, Fabrizio, Mazzini, Letizia, Messina, Sonia, D'Alfonso, Sandra, Corrado, Lucia, Ferrucci, Luigi, Harms, Matthew B., Goldstein, David B., Shneider, Neil A., Goutman, Stephen, Simmons, Zachary, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Manousakis, George, Appel, Stanley, Simpson, Ericka, Wang, Leo, Baloh, Robert H., Gibson, Summer, Bedlack, Richard S., Lacomis, David, Sareen, Dhruv, Sherman, Alexander, Bruijn, Lucie, Penny, Michelle, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Allen, Andrew S., Boone, Braden E., Brown, Robert, Carulli, John P., Chesi, Alessandra, Chung, Wendy K., Cirulli, Elizabeth T., Cooper, Gregory M., Couthouis, Julien, Day-Williams, Aaron G., Dion, Patrick A., Gitler, Aaron D., Glass, Jonathan D., Han, Yujun, Harris, Tim, Hayes, Sebastian D., Jones, Angela L., Keebler, Jonathan, Krueger, Brian J., Lasseigne, Brittany N., Levy, Shawn E., Lu, Yi-Fan, Maniatis, Tom, McKenna-Yasek, Diane, Myers, Richard M., Petrovski, Slavé, Pulst, Stefan M., Raphael, Alya R., Ravits, John M., Ren, Zhong, Rouleau, Guy A., Sapp, Peter C., Sims, Katherine B., Staropoli, John F., Waite, Lindsay L., Wang, Quanli, Wimbish, Jack R., Xin, Winnie W., Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steven, Dardiotis, Efthimios, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos A., Dubnau, Joshua, Nath, Avindra, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C., Kaye, Julia, Wyman, Stacia, LeNail, Alexander, Lima, Leandro, Rothstein, Jeffrey D., Svendsen, Clive N., Van Eyk, Jenny, Maragakis, Nicholas J., Kolb, Stephen J., Cudkowicz, Merit, Baxi, Emily, Wyman, Stacia K., Van Eyk, Jennifer E., Benatar, Michael, Taylor, J. Paul, Wu, Gang, Rampersaud, Evadnie, Wuu, Joanne, Rademakers, Rosa, Züchner, Stephan, Schule, Rebecca, McCauley, Jacob, Hussain, Sumaira, Cooley, Anne, Wallace, Marielle, Clayman, Christine, Barohn, Richard, Statland, Jeffrey, Ravits, John, Swenson, Andrea, Jackson, Carlayne, Trivedi, Jaya, Khan, Shaida, Katz, Jonathan, Jenkins, Liberty, Burns, Ted, Gwathmey, Kelly, Caress, James, McMillan, Corey, Elman, Lauren, Pioro, Erik, Heckmann, Jeannine, So, Yuen, Walk, David, Maiser, Samuel, Zhang, Jinghui, Silani, Vincenzo, Gellera, Cinzia, Ratti, Antonia, Taroni, Franco, Lauria, Giuseppe, Verde, Federico, Fogh, Isabella, Tiloca, Cinzia, Comi, Giacomo P., Sorarù, Gianni, Cereda, Cristina, De Marchi, Fabiola, Corti, Stefania, Ceroni, Mauro, Siciliano, Gabriele, Filosto, Massimiliano, Inghilleri, Maurizio, Peverelli, Silvia, Colombrita, Claudia, Poletti, Barbara, Maderna, Luca, Del Bo, Roberto, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, Pensato, Viviana, Castellotti, Barbara, Camu, William, Mouzat, Kevin, Lumbroso, Serge, Corcia, Philippe, Meininger, Vincent, Besson, Gérard, Lagrange, Emmeline, Clavelou, Pierre, Guy, Nathalie, Couratier, Philippe, Vourch, Patrick, Danel, Véronique, Bernard, Emilien, Lemasson, Gwendal, Laaksovirta, Hannu, Myllykangas, Liisa, Jansson, Lilja, Valori, Miko, Ealing, John, Hamdalla, Hisham, Rollinson, Sara, Pickering-Brown, Stuart, Orrell, Richard W., Sidle, Katie C., Hardy, John, Singleton, Andrew B., Johnson, Janel O., Arepalli, Sampath, Polak, Meraida, Asress, Seneshaw, Al-Sarraj, Safa, King, Andrew, Troakes, Claire, Vance, Caroline, de Belleroche, Jacqueline, ten Asbroek, Anneloor L. M. A., Muñoz-Blanco, José Luis, Hernandez, Dena G., Ding, Jinhui, Gibbs, J. Raphael, Scholz, Sonja W., Floeter, Mary Kay, Campbell, Roy H., Landi, Francesco, Bowser, Robert, MacGowan, Daniel J. L., Kirby, Janine, Pioro, Erik P., Pamphlett, Roger, Broach, James, Gerhard, Glenn, Dunckley, Travis L., Brady, Christopher B., Kowall, Neil W., Troncoso, Juan C., Le Ber, Isabelle, Heiman-Patterson, Terry D., Kamel, Freya, Van Den Bosch, Ludo, Strom, Tim M., Meitinger, Thomas, Shatunov, Aleksey, Van Eijk, Kristel R., de Carvalho, Mamede, Kooyman, Maarten, Middelkoop, Bas, Moisse, Mattieu, McLaughlin, Russell L., Van Es, Michael A., Weber, Markus, Boylan, Kevin B., Van Blitterswijk, Marka, Morrison, Karen E., Basak, A. Nazli, Mora, Jesús S., Drory, Vivian E., Shaw, Pamela J., Turner, Martin R., Talbot, Kevin, Hardiman, Orla, Williams, Kelly L., Fifita, Jennifer A., Nicholson, Garth A., Blair, Ian P., Esteban-Pérez, Jesús, García-Redondo, Alberto, Al-Chalabi, Ammar, Al Kheifat, Ahmad, Andersen, Peter, Chio, Adriano, Cooper-Knock, Jonathan, Dekker, Annelot, Drory, Vivian, Redondo, Alberto Garcia, Gotkine, Marc, Hide, Winston, Iacoangeli, Alfredo, Glass, Jonathan, Kenna, Kevin, Kiernan, Matthew, Landers, John, McLaughlin, Russell, Mill, Jonathan, Neto, Miguel Mitne, Pardina, Jesus Mora, Morrison, Karen, Newhouse, Stephen, Pinto, Susana, Pulit, Sara, Robberecht, Wim, Shaw, Pamela, Shaw, Chris, Sproviero, William, Tazelaar, Gijs, van Damme, Philip, van den Berg, Leonard, van Eijk, Kristel, van Es, Michael, van Vugt, Joke, Veldink, Jan, Zatz, Mayana, Bauer, Denis C., Twine, Natalie A., Rogaeva, Ekaterina, Zinman, Lorne, Brice, Alexis, Goutman, Stephen A., Feldman, Eva L., Gibson, Summer B., Ludolph, Albert C., Andersen, Peter M., Weishaupt, Jochen H., Trojanowski, John Q., Brown, Robert H., van den Berg, Leonard H., Veldink, Jan H., Stone, David J., Tienari, Pentti, Chiò, Adriano, Shaw, Christopher E., Traynor, Bryan J., Landers, John E., Nicolas, A, Kenna, K, Renton, A, Ticozzi, N, Faghri, F, Chia, R, Dominov, J, Kenna, B, Nalls, M, Keagle, P, Rivera, A, van Rheenen, W, Murphy, N, van Vugt, J, Geiger, J, van der Spek, R, Pliner, H, Shankaracharya, N, Smith, B, Marangi, G, Topp, S, Abramzon, Y, Gkazi, A, Eicher, J, Kenna, A, Logullo, F, Simone, I, Logroscino, G, Salvi, F, Bartolomei, I, Borghero, G, Murru, M, Costantino, E, Pani, C, Puddu, R, Caredda, C, Piras, V, Tranquilli, S, Cuccu, S, Corongiu, D, Melis, M, Milia, A, Marrosu, F, Marrosu, M, Floris, G, Cannas, A, Capasso, M, Caponnetto, C, Mancardi, G, Origone, P, Mandich, P, Conforti, F, Cavallaro, S, Mora, G, Marinou, K, Sideri, R, Penco, S, Mosca, L, Lunetta, C, Pinter, G, Corbo, M, Riva, N, Carrera, P, Volanti, P, Mandrioli, J, Fini, N, Fasano, A, Tremolizzo, L, Arosio, A, Ferrarese, C, Trojsi, F, Tedeschi, G, Monsurrò, M, Piccirillo, G, Femiano, C, Ticca, A, Ortu, E, La Bella, V, Spataro, R, Colletti, T, Sabatelli, M, Zollino, M, Conte, A, Luigetti, M, Lattante, S, Santarelli, M, Petrucci, A, Pugliatti, M, Pirisi, A, Parish, L, Occhineri, P, Giannini, F, Battistini, S, Ricci, C, Benigni, M, Cau, T, Loi, D, Calvo, A, Moglia, C, Brunetti, M, Barberis, M, Restagno, G, Casale, F, Marrali, G, Fuda, G, Ossola, I, Cammarosano, S, Canosa, A, Ilardi, A, Manera, U, Grassano, M, Tanel, R, Pisano, F, Mazzini, L, Messina, S, D'Alfonso, S, Corrado, L, Ferrucci, L, Harms, M, Goldstein, D, Shneider, N, Goutman, S, Simmons, Z, Miller, T, Chandran, S, Pal, S, Manousakis, G, Appel, S, Simpson, E, Wang, L, Baloh, R, Gibson, S, Bedlack, R, Lacomis, D, Sareen, D, Sherman, A, Bruijn, L, Penny, M, Moreno, C, Kamalakaran, S, Allen, A, Boone, B, Brown, R, Carulli, J, Chesi, A, Chung, W, Cirulli, E, Cooper, G, Couthouis, J, Day-Williams, A, Dion, P, Gitler, A, Glass, J, Han, Y, Harris, T, Hayes, S, Jones, A, Keebler, J, Krueger, B, Lasseigne, B, Levy, S, Lu, Y, Maniatis, T, McKenna-Yasek, D, Myers, R, Petrovski, S, Pulst, S, Raphael, A, Ravits, J, Ren, Z, Rouleau, G, Sapp, P, Sims, K, Staropoli, J, Waite, L, Wang, Q, Wimbish, J, Xin, W, Phatnani, H, Kwan, J, Broach, J, Arcila-Londono, X, Lee, E, Van Deerlin, V, Fraenkel, E, Ostrow, L, Baas, F, Zaitlen, N, Berry, J, Malaspina, A, Fratta, P, Cox, G, Thompson, L, Finkbeiner, S, Dardiotis, E, Hornstein, E, Macgowan, D, Heiman-Patterson, T, Hammell, M, Patsopoulos, N, Dubnau, J, Nath, A, Musunuri, R, Evani, U, Abhyankar, A, Zody, M, Kaye, J, Wyman, S, Lenail, A, Lima, L, Rothstein, J, Svendsen, C, Van Eyk, J, Maragakis, N, Kolb, S, Cudkowicz, M, Baxi, E, Benatar, M, Taylor, J, Wu, G, Rampersaud, E, Wuu, J, Rademakers, R, Züchner, S, Schule, R, Mccauley, J, Hussain, S, Cooley, A, Wallace, M, Clayman, C, Barohn, R, Statland, J, Swenson, A, Jackson, C, Trivedi, J, Khan, S, Katz, J, Jenkins, L, Burns, T, Gwathmey, K, Caress, J, Mcmillan, C, Elman, L, Pioro, E, Heckmann, J, So, Y, Walk, D, Maiser, S, Zhang, J, Silani, V, Gellera, C, Ratti, A, Taroni, F, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, G, Sorarù, G, Cereda, C, De Marchi, F, Corti, S, Ceroni, M, Siciliano, G, Filosto, M, Inghilleri, M, Peverelli, S, Colombrita, C, Poletti, B, Maderna, L, Del Bo, R, Gagliardi, S, Querin, G, Bertolin, C, Pensato, V, Castellotti, B, Camu, W, Mouzat, K, Lumbroso, S, Corcia, P, Meininger, V, Besson, G, Lagrange, E, Clavelou, P, Guy, N, Couratier, P, Vourch, P, Danel, V, Bernard, E, Lemasson, G, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, R, Sidle, K, Hardy, J, Singleton, A, Johnson, J, Arepalli, S, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, de Belleroche, J, ten Asbroek, A, Muñoz-Blanco, J, Hernandez, D, Ding, J, Gibbs, J, Scholz, S, Floeter, M, Campbell, R, Landi, F, Bowser, R, Kirby, J, Pamphlett, R, Gerhard, G, Dunckley, T, Brady, C, Kowall, N, Troncoso, J, Le Ber, I, Kamel, F, Van Den Bosch, L, Strom, T, Meitinger, T, Shatunov, A, Van Eijk, K, de Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, Mclaughlin, R, Van Es, M, Weber, M, Boylan, K, Van Blitterswijk, M, Morrison, K, Basak, A, Mora, J, Drory, V, Shaw, P, Turner, M, Talbot, K, Hardiman, O, Williams, K, Fifita, J, Nicholson, G, Blair, I, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Al Kheifat, A, Andersen, P, Chio, A, Cooper-Knock, J, Dekker, A, Redondo, A, Gotkine, M, Hide, W, Iacoangeli, A, Kiernan, M, Landers, J, Mill, J, Neto, M, Pardina, J, Newhouse, S, Pinto, S, Pulit, S, Robberecht, W, Shaw, C, Sproviero, W, Tazelaar, G, van Damme, P, van den Berg, L, van Eijk, K, van Es, M, Veldink, J, Zatz, M, Bauer, D, Twine, N, Rogaeva, E, Zinman, L, Brice, A, Feldman, E, Ludolph, A, Weishaupt, J, Trojanowski, J, Stone, D, Tienari, P, Chiò, A, Traynor, B, Nicolas, Aude, Kenna, Kevin P., Renton, Alan E., Ticozzi, Nicola, Faghri, Faraz, Chia, Ruth, Dominov, Janice A., Kenna, Brendan J., Nalls, Mike A., Keagle, Pamela, Rivera, Alberto M., van Rheenen, Wouter, Murphy, Natalie A., van Vugt, Joke J. F. A., Geiger, Joshua T., van der Spek, Rick, Pliner, Hannah A., Shankaracharya, null, Smith, Bradley N., Marangi, Giuseppe, Topp, Simon D., Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D., Kenna, Aoife, Logullo, Francesco O., Simone, Isabella, Logroscino, Giancarlo, Salvi, Fabrizio, Bartolomei, Ilaria, Borghero, Giuseppe, Murru, Maria Rita, Costantino, Emanuela, Pani, Carla, Puddu, Roberta, Caredda, Carla, Piras, Valeria, Tranquilli, Stefania, Cuccu, Stefania, Corongiu, Daniela, Melis, Maurizio, Milia, Antonio, Marrosu, Francesco, Marrosu, Maria Giovanna, Floris, Gianluca, Cannas, Antonino, Capasso, Margherita, Caponnetto, Claudia, Mancardi, Gianluigi, Origone, Paola, Mandich, Paola, Conforti, Francesca L., Cavallaro, Sebastiano, Mora, Gabriele, Marinou, Kalliopi, Sideri, Riccardo, Penco, Silvana, Mosca, Lorena, Lunetta, Christian, Pinter, Giuseppe Lauria, Corbo, Massimo, Riva, Nilo, Carrera, Paola, Volanti, Paolo, Mandrioli, Jessica, Fini, Nicola, Fasano, Antonio, Tremolizzo, Lucio, Arosio, Alessandro, Ferrarese, Carlo, Trojsi, Francesca, Tedeschi, Gioacchino, Monsurrò, Maria Rosaria, Piccirillo, Giovanni, Femiano, Cinzia, Ticca, Anna, Ortu, Enzo, La Bella, Vincenzo, Spataro, Rossella, Colletti, Tiziana, Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, Marialuisa, Petrucci, Antonio, Pugliatti, Maura, Pirisi, Angelo, Parish, Leslie D., Occhineri, Patrizia, Giannini, Fabio, Battistini, Stefania, Ricci, Claudia, Benigni, Michele, Cau, Tea B., Loi, Daniela, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Barberis, Marco, Restagno, Gabriella, Casale, Federico, Marrali, Giuseppe, Fuda, Giuseppe, Ossola, Irene, Cammarosano, Stefania, Canosa, Antonio, Ilardi, Antonio, Manera, Umberto, Grassano, Maurizio, Tanel, Raffaella, Pisano, Fabrizio, Mazzini, Letizia, Messina, Sonia, D'Alfonso, Sandra, Corrado, Lucia, Ferrucci, Luigi, Harms, Matthew B., Goldstein, David B., Shneider, Neil A., Goutman, Stephen, Simmons, Zachary, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Manousakis, George, Appel, Stanley, Simpson, Ericka, Wang, Leo, Baloh, Robert H., Gibson, Summer, Bedlack, Richard S., Lacomis, David, Sareen, Dhruv, Sherman, Alexander, Bruijn, Lucie, Penny, Michelle, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Allen, Andrew S., Boone, Braden E., Brown, Robert, Carulli, John P., Chesi, Alessandra, Chung, Wendy K., Cirulli, Elizabeth T., Cooper, Gregory M., Couthouis, Julien, Day-Williams, Aaron G., Dion, Patrick A., Gitler, Aaron D., Glass, Jonathan D., Han, Yujun, Harris, Tim, Hayes, Sebastian D., Jones, Angela L., Keebler, Jonathan, Krueger, Brian J., Lasseigne, Brittany N., Levy, Shawn E., Lu, Yi-Fan, Maniatis, Tom, McKenna-Yasek, Diane, Myers, Richard M., Petrovski, Slavé, Pulst, Stefan M., Raphael, Alya R., Ravits, John M., Ren, Zhong, Rouleau, Guy A., Sapp, Peter C., Sims, Katherine B., Staropoli, John F., Waite, Lindsay L., Wang, Quanli, Wimbish, Jack R., Xin, Winnie W., Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steven, Dardiotis, Efthimios, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos A., Dubnau, Joshua, Nath, Avindra, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C., Kaye, Julia, Wyman, Stacia, LeNail, Alexander, Lima, Leandro, Rothstein, Jeffrey D., Svendsen, Clive N., Van Eyk, Jenny, Maragakis, Nicholas J., Kolb, Stephen J., Cudkowicz, Merit, Baxi, Emily, Wyman, Stacia K., Van Eyk, Jennifer E., Benatar, Michael, Taylor, J. Paul, Wu, Gang, Rampersaud, Evadnie, Wuu, Joanne, Rademakers, Rosa, Züchner, Stephan, Schule, Rebecca, McCauley, Jacob, Hussain, Sumaira, Cooley, Anne, Wallace, Marielle, Clayman, Christine, Barohn, Richard, Statland, Jeffrey, Ravits, John, Swenson, Andrea, Jackson, Carlayne, Trivedi, Jaya, Khan, Shaida, Katz, Jonathan, Jenkins, Liberty, Burns, Ted, Gwathmey, Kelly, Caress, James, McMillan, Corey, Elman, Lauren, Pioro, Erik, Heckmann, Jeannine, So, Yuen, Walk, David, Maiser, Samuel, Zhang, Jinghui, Silani, Vincenzo, Gellera, Cinzia, Ratti, Antonia, Taroni, Franco, Lauria, Giuseppe, Verde, Federico, Fogh, Isabella, Tiloca, Cinzia, Comi, Giacomo P., Sorarù, Gianni, Cereda, Cristina, De Marchi, Fabiola, Corti, Stefania, Ceroni, Mauro, Siciliano, Gabriele, Filosto, Massimiliano, Inghilleri, Maurizio, Peverelli, Silvia, Colombrita, Claudia, Poletti, Barbara, Maderna, Luca, Del Bo, Roberto, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, Pensato, Viviana, Castellotti, Barbara, Camu, William, Mouzat, Kevin, Lumbroso, Serge, Corcia, Philippe, Meininger, Vincent, Besson, Gérard, Lagrange, Emmeline, Clavelou, Pierre, Guy, Nathalie, Couratier, Philippe, Vourch, Patrick, Danel, Véronique, Bernard, Emilien, Lemasson, Gwendal, Laaksovirta, Hannu, Myllykangas, Liisa, Jansson, Lilja, Valori, Miko, Ealing, John, Hamdalla, Hisham, Rollinson, Sara, Pickering-Brown, Stuart, Orrell, Richard W., Sidle, Katie C., Hardy, John, Singleton, Andrew B., Johnson, Janel O., Arepalli, Sampath, Polak, Meraida, Asress, Seneshaw, Al-Sarraj, Safa, King, Andrew, Troakes, Claire, Vance, Caroline, de Belleroche, Jacqueline, ten Asbroek, Anneloor L. M. A., Muñoz-Blanco, José Luis, Hernandez, Dena G., Ding, Jinhui, Gibbs, J. Raphael, Scholz, Sonja W., Floeter, Mary Kay, Campbell, Roy H., Landi, Francesco, Bowser, Robert, MacGowan, Daniel J. L., Kirby, Janine, Pioro, Erik P., Pamphlett, Roger, Broach, James, Gerhard, Glenn, Dunckley, Travis L., Brady, Christopher B., Kowall, Neil W., Troncoso, Juan C., Le Ber, Isabelle, Heiman-Patterson, Terry D., Kamel, Freya, Van Den Bosch, Ludo, Strom, Tim M., Meitinger, Thomas, Shatunov, Aleksey, Van Eijk, Kristel R., de Carvalho, Mamede, Kooyman, Maarten, Middelkoop, Bas, Moisse, Mattieu, McLaughlin, Russell L., Van Es, Michael A., Weber, Markus, Boylan, Kevin B., Van Blitterswijk, Marka, Morrison, Karen E., Basak, A. Nazli, Mora, Jesús S., Drory, Vivian E., Shaw, Pamela J., Turner, Martin R., Talbot, Kevin, Hardiman, Orla, Williams, Kelly L., Fifita, Jennifer A., Nicholson, Garth A., Blair, Ian P., Esteban-Pérez, Jesús, García-Redondo, Alberto, Al-Chalabi, Ammar, Al Kheifat, Ahmad, Andersen, Peter, Chio, Adriano, Cooper-Knock, Jonathan, Dekker, Annelot, Drory, Vivian, Redondo, Alberto Garcia, Gotkine, Marc, Hide, Winston, Iacoangeli, Alfredo, Glass, Jonathan, Kenna, Kevin, Kiernan, Matthew, Landers, John, McLaughlin, Russell, Mill, Jonathan, Neto, Miguel Mitne, Pardina, Jesus Mora, Morrison, Karen, Newhouse, Stephen, Pinto, Susana, Pulit, Sara, Robberecht, Wim, Shaw, Pamela, Shaw, Chris, Sproviero, William, Tazelaar, Gijs, van Damme, Philip, van den Berg, Leonard, van Eijk, Kristel, van Es, Michael, van Vugt, Joke, Veldink, Jan, Zatz, Mayana, Bauer, Denis C., Twine, Natalie A., Rogaeva, Ekaterina, Zinman, Lorne, Brice, Alexis, Goutman, Stephen A., Feldman, Eva L., Gibson, Summer B., Ludolph, Albert C., Andersen, Peter M., Weishaupt, Jochen H., Trojanowski, John Q., Brown, Robert H., van den Berg, Leonard H., Veldink, Jan H., Stone, David J., Tienari, Pentti, Chiò, Adriano, Shaw, Christopher E., Traynor, Bryan J., and Landers, John E.

Abstract

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS. Using a large-scale genome-wide association study and exome sequencing, we identified KIF5A as a novel gene associated with ALS. Our data broaden the phenotype resulting from mutations in KIF5A and highlight the importance of cytoskeletal defects in the pathogenesis of ALS.

Published
2018

24. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

Author

Nicolas, A., Kenna, K. P., Renton, A. E., Ticozzi, N., Faghri, F., Chia, R., Dominov, J. A., Kenna, B. J., Nalls, M. A., Keagle, P., Rivera, A. M., van Rheenen, W., Murphy, N. A., van Vugt, J. J. F. A., Geiger, J. T., Van der Spek, R. A., Pliner, H. A., Shankaracharya, Smith, B. N., Marangi, Giuseppe, Topp, S. D., Abramzon, Y., Gkazi, A. S., Eicher, J. D., Kenna, A., Logullo, F. O., Simone, I. L., Logroscino, Giandomenico, Salvi, F., Bartolomei, I., Borghero, G., Murru, M. R., Costantino, E., Pani, C., Puddu, R., Caredda, C., Piras, V., Tranquilli, S., Cuccu, S., Corongiu, D., Melis, M., Milia, A., Marrosu, F., Marrosu, M. G., Floris, G., Cannas, A., Capasso, Monica, Caponnetto, C., Mancardi, G., Origone, P., Mandich, P., Conforti, F. L., Cavallaro, S., Mora, G., Marinou, K., Sideri, R., Penco, S., Mosca, Luigi, Lunetta, C., Pinter, G. L., Corbo, M., Riva, N., Carrera, P., Volanti, P., Mandrioli, J., Fini, N., Fasano, Alfonso, Tremolizzo, L., Arosio, A., Ferrarese, C., Trojsi, F., Tedeschi, G., Monsurro, M. R., Piccirillo, G., Femiano, C., Ticca, A., Ortu, E., La Bella, V., Spataro, R., Colletti, T., Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, M., Petrucci, A., Pugliatti, M., Pirisi, A., Parish, L. D., Occhineri, P., Giannini, F., Battistini, S., Ricci, C., Benigni, M., Cau, T. B., Loi, D., Calvo, A., Moglia, C., Brunetti, M., Barberis, M., Restagno, G., Casale, F., Marrali, G., Fuda, G., Ossola, I., Cammarosano, S., Canosa, A., Ilardi, A., Manera, U., Grassano, M., Tanel, R., Pisano, F., Mazzini, L., Messina, S., D'Alfonso, Sandra, Corrado, L., Ferrucci, L., Harms, M. B., Goldstein, D. B., Shneider, N. A., Goutman, S. A., Simmons, Z., Miller, T. M., Chandran, S., Pal, S., Manousakis, G., Appel, S. H., Simpson, E., Wang, L., Baloh, R. H., Gibson, S. B., Bedlack, R., Lacomis, D., Sareen, D., Sherman, A., Bruijn, L., Penny, M., Moreno, C. D. A. M., Kamalakaran, S., Allen, A. S., Boone, B. E., Brown, R. H., Carulli, J. P., Chesi, A., Chung, W. K., Cirulli, E. T., Cooper, G. M., Couthouis, J., Day-Williams, A. G., Dion, P. A., Gitler, A. D., Glass, J. D., Han, Y., Harris, T., Hayes, S. D., Jones, A. L., Keebler, J., Krueger, B. J., Lasseigne, B. N., Levy, S. E., Lu, Y. -F., Maniatis, T., McKenna-Yasek, D., Myers, R. M., Petrovski, S., Pulst, S. M., Raphael, A. R., Ravits, J. M., Ren, Z., Rouleau, G. A., Sapp, P. C., Sims, K. B., Staropoli, J. F., Waite, L. L., Wang, Quanquan, Wimbish, J. R., Xin, W. W., Phatnani, H., Kwan, J., Broach, J., Arcila-Londono, X., Lee, E. B., Van Deerlin, V. M., Fraenkel, E., Ostrow, L. W., Baas, F., Zaitlen, N., Berry, J. D., Malaspina, A., Fratta, P., Cox, G. A., Thompson, L. M., Finkbeiner, S., Dardiotis, E., Hornstein, E., Macgowan, D. J. L., Heiman-Patterson, T., Hammell, M. G., Patsopoulos, N. A., Dubnau, J., Nath, A., Musunuri, R. L., Evani, U. S., Abhyankar, A., Zody, M. C., Kaye, J., Wyman, S. K., Lenail, A., Lima, L., Rothstein, J. D., Svendsen, C. N., Van Eyk, J. E., Maragakis, N. J., Kolb, S. J., Cudkowicz, M., Baxi, E., Benatar, M., Taylor, J. P., Wu, G., Rampersaud, E., Wuu, J., Rademakers, R., Zuchner, S., Schule, R., Mccauley, J., Hussain, S., Cooley, A., Wallace, M., Clayman, C., Barohn, R., Statland, J., Swenson, A., Jackson, C., Trivedi, J., Khan, S., Katz, J., Jenkins, L., Burns, T., Gwathmey, K., Caress, J., Mcmillan, C., Elman, L., Pioro, E. P., Heckmann, J., So, Y., Walk, D., Maiser, S., Zhang, J., Silani, V., Gellera, C., Ratti, A., Taroni, F., Lauria, G., Verde, F., Fogh, I., Tiloca, C., Comi, G. P., Soraru, G., Cereda, C., De Marchi, F., Corti, S., Ceroni, M., Siciliano, Giovanni, Filosto, M., Inghilleri, M., Peverelli, S., Colombrita, C., Poletti, B., Maderna, L., Del Bo, R., Gagliardi, S., Querin, G., Bertolin, C., Pensato, V., Castellotti, B., Camu, W., Mouzat, K., Lumbroso, S., Corcia, P., Meininger, V., Besson, G., Lagrange, E., Clavelou, P., Guy, N., Couratier, P., Vourch, P., Danel, V., Bernard, E., Lemasson, G., Laaksovirta, H., Myllykangas, L., Jansson, L., Valori, Vanna Maria, Ealing, J., Hamdalla, H., Rollinson, S., Pickering-Brown, S., Orrell, R. W., Sidle, K. C., Hardy, J., Singleton, A. B., Johnson, J. O., Arepalli, S., Polak, M., Asress, S., Al-Sarraj, S., King, A., Troakes, C., Vance, C., de Belleroche, J., ten Asbroek, A. L. M. A., Munoz-Blanco, J. L., Hernandez, D. G., Ding, J., Gibbs, J. R., Scholz, S. W., Floeter, M. K., Campbell, R. H., Landi, Francesco, Bowser, R., Kirby, J., Pamphlett, R., Gerhard, G., Dunckley, T. L., Brady, C. B., Kowall, N. W., Troncoso, J. C., Le Ber, I., Heiman-Patterson, T. D., Kamel, F., Van Den Bosch, L., Strom, T. M., Meitinger, T., Shatunov, A., Van Eijk, K. R., de Carvalho, M., Kooyman, M., Middelkoop, B., Moisse, M., Mclaughlin, R. L., Van Es, M. A., Weber, M., Boylan, K. B., Van Blitterswijk, M., Morrison, K. E., Basak, A. N., Mora, J. S., Drory, V. E., Shaw, P. J., Turner, M. R., Talbot, K., Hardiman, O., Williams, K. L., Fifita, J. A., Nicholson, G. A., Blair, I. P., Esteban-Perez, J., Garcia-Redondo, A., Al-Chalabi, A., Al Kheifat, A., Andersen, P. M., Chio, A., Cooper-Knock, J., Dekker, A., Redondo, A. G., Gotkine, M., Hide, W., Iacoangeli, A., Kiernan, M., Landers, J. E., Mill, J., Neto, M. M., Pardina, J. M., Newhouse, S., Pinto, S., Pulit, S., Robberecht, W., Shaw, C., Sproviero, W., Tazelaar, G., Van Damme, P., van den Berg, L. H., van Vugt, J., Veldink, J. H., Zatz, M., Bauer, D. C., Twine, N. A., Rogaeva, E., Zinman, L., Brice, A., Feldman, E. L., Ludolph, A. C., Weishaupt, J. H., Trojanowski, J. Q., Stone, D. J., Tienari, P., Shaw, C. E., Traynor, B. J., Marangi G. (ORCID:0000-0002-6898-8882), Logroscino G. (ORCID:0000-0003-1301-5343), Capasso M., Mosca L. (ORCID:0000-0003-4641-0841), Fasano A., Sabatelli M. (ORCID:0000-0001-6635-4985), Zollino M. (ORCID:0000-0003-4871-9519), Conte A., Luigetti M. (ORCID:0000-0001-7539-505X), Lattante S. (ORCID:0000-0003-2891-0340), D'Alfonso S., Siciliano G., Valori M., Landi F. (ORCID:0000-0002-3472-1389), Nicolas, A., Kenna, K. P., Renton, A. E., Ticozzi, N., Faghri, F., Chia, R., Dominov, J. A., Kenna, B. J., Nalls, M. A., Keagle, P., Rivera, A. M., van Rheenen, W., Murphy, N. A., van Vugt, J. J. F. A., Geiger, J. T., Van der Spek, R. A., Pliner, H. A., Shankaracharya, Smith, B. N., Marangi, Giuseppe, Topp, S. D., Abramzon, Y., Gkazi, A. S., Eicher, J. D., Kenna, A., Logullo, F. O., Simone, I. L., Logroscino, Giandomenico, Salvi, F., Bartolomei, I., Borghero, G., Murru, M. R., Costantino, E., Pani, C., Puddu, R., Caredda, C., Piras, V., Tranquilli, S., Cuccu, S., Corongiu, D., Melis, M., Milia, A., Marrosu, F., Marrosu, M. G., Floris, G., Cannas, A., Capasso, Monica, Caponnetto, C., Mancardi, G., Origone, P., Mandich, P., Conforti, F. L., Cavallaro, S., Mora, G., Marinou, K., Sideri, R., Penco, S., Mosca, Luigi, Lunetta, C., Pinter, G. L., Corbo, M., Riva, N., Carrera, P., Volanti, P., Mandrioli, J., Fini, N., Fasano, Alfonso, Tremolizzo, L., Arosio, A., Ferrarese, C., Trojsi, F., Tedeschi, G., Monsurro, M. R., Piccirillo, G., Femiano, C., Ticca, A., Ortu, E., La Bella, V., Spataro, R., Colletti, T., Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, M., Petrucci, A., Pugliatti, M., Pirisi, A., Parish, L. D., Occhineri, P., Giannini, F., Battistini, S., Ricci, C., Benigni, M., Cau, T. B., Loi, D., Calvo, A., Moglia, C., Brunetti, M., Barberis, M., Restagno, G., Casale, F., Marrali, G., Fuda, G., Ossola, I., Cammarosano, S., Canosa, A., Ilardi, A., Manera, U., Grassano, M., Tanel, R., Pisano, F., Mazzini, L., Messina, S., D'Alfonso, Sandra, Corrado, L., Ferrucci, L., Harms, M. B., Goldstein, D. B., Shneider, N. A., Goutman, S. A., Simmons, Z., Miller, T. M., Chandran, S., Pal, S., Manousakis, G., Appel, S. H., Simpson, E., Wang, L., Baloh, R. H., Gibson, S. B., Bedlack, R., Lacomis, D., Sareen, D., Sherman, A., Bruijn, L., Penny, M., Moreno, C. D. A. M., Kamalakaran, S., Allen, A. S., Boone, B. E., Brown, R. H., Carulli, J. P., Chesi, A., Chung, W. K., Cirulli, E. T., Cooper, G. M., Couthouis, J., Day-Williams, A. G., Dion, P. A., Gitler, A. D., Glass, J. D., Han, Y., Harris, T., Hayes, S. D., Jones, A. L., Keebler, J., Krueger, B. J., Lasseigne, B. N., Levy, S. E., Lu, Y. -F., Maniatis, T., McKenna-Yasek, D., Myers, R. M., Petrovski, S., Pulst, S. M., Raphael, A. R., Ravits, J. M., Ren, Z., Rouleau, G. A., Sapp, P. C., Sims, K. B., Staropoli, J. F., Waite, L. L., Wang, Quanquan, Wimbish, J. R., Xin, W. W., Phatnani, H., Kwan, J., Broach, J., Arcila-Londono, X., Lee, E. B., Van Deerlin, V. M., Fraenkel, E., Ostrow, L. W., Baas, F., Zaitlen, N., Berry, J. D., Malaspina, A., Fratta, P., Cox, G. A., Thompson, L. M., Finkbeiner, S., Dardiotis, E., Hornstein, E., Macgowan, D. J. L., Heiman-Patterson, T., Hammell, M. G., Patsopoulos, N. A., Dubnau, J., Nath, A., Musunuri, R. L., Evani, U. S., Abhyankar, A., Zody, M. C., Kaye, J., Wyman, S. K., Lenail, A., Lima, L., Rothstein, J. D., Svendsen, C. N., Van Eyk, J. E., Maragakis, N. J., Kolb, S. J., Cudkowicz, M., Baxi, E., Benatar, M., Taylor, J. P., Wu, G., Rampersaud, E., Wuu, J., Rademakers, R., Zuchner, S., Schule, R., Mccauley, J., Hussain, S., Cooley, A., Wallace, M., Clayman, C., Barohn, R., Statland, J., Swenson, A., Jackson, C., Trivedi, J., Khan, S., Katz, J., Jenkins, L., Burns, T., Gwathmey, K., Caress, J., Mcmillan, C., Elman, L., Pioro, E. P., Heckmann, J., So, Y., Walk, D., Maiser, S., Zhang, J., Silani, V., Gellera, C., Ratti, A., Taroni, F., Lauria, G., Verde, F., Fogh, I., Tiloca, C., Comi, G. P., Soraru, G., Cereda, C., De Marchi, F., Corti, S., Ceroni, M., Siciliano, Giovanni, Filosto, M., Inghilleri, M., Peverelli, S., Colombrita, C., Poletti, B., Maderna, L., Del Bo, R., Gagliardi, S., Querin, G., Bertolin, C., Pensato, V., Castellotti, B., Camu, W., Mouzat, K., Lumbroso, S., Corcia, P., Meininger, V., Besson, G., Lagrange, E., Clavelou, P., Guy, N., Couratier, P., Vourch, P., Danel, V., Bernard, E., Lemasson, G., Laaksovirta, H., Myllykangas, L., Jansson, L., Valori, Vanna Maria, Ealing, J., Hamdalla, H., Rollinson, S., Pickering-Brown, S., Orrell, R. W., Sidle, K. C., Hardy, J., Singleton, A. B., Johnson, J. O., Arepalli, S., Polak, M., Asress, S., Al-Sarraj, S., King, A., Troakes, C., Vance, C., de Belleroche, J., ten Asbroek, A. L. M. A., Munoz-Blanco, J. L., Hernandez, D. G., Ding, J., Gibbs, J. R., Scholz, S. W., Floeter, M. K., Campbell, R. H., Landi, Francesco, Bowser, R., Kirby, J., Pamphlett, R., Gerhard, G., Dunckley, T. L., Brady, C. B., Kowall, N. W., Troncoso, J. C., Le Ber, I., Heiman-Patterson, T. D., Kamel, F., Van Den Bosch, L., Strom, T. M., Meitinger, T., Shatunov, A., Van Eijk, K. R., de Carvalho, M., Kooyman, M., Middelkoop, B., Moisse, M., Mclaughlin, R. L., Van Es, M. A., Weber, M., Boylan, K. B., Van Blitterswijk, M., Morrison, K. E., Basak, A. N., Mora, J. S., Drory, V. E., Shaw, P. J., Turner, M. R., Talbot, K., Hardiman, O., Williams, K. L., Fifita, J. A., Nicholson, G. A., Blair, I. P., Esteban-Perez, J., Garcia-Redondo, A., Al-Chalabi, A., Al Kheifat, A., Andersen, P. M., Chio, A., Cooper-Knock, J., Dekker, A., Redondo, A. G., Gotkine, M., Hide, W., Iacoangeli, A., Kiernan, M., Landers, J. E., Mill, J., Neto, M. M., Pardina, J. M., Newhouse, S., Pinto, S., Pulit, S., Robberecht, W., Shaw, C., Sproviero, W., Tazelaar, G., Van Damme, P., van den Berg, L. H., van Vugt, J., Veldink, J. H., Zatz, M., Bauer, D. C., Twine, N. A., Rogaeva, E., Zinman, L., Brice, A., Feldman, E. L., Ludolph, A. C., Weishaupt, J. H., Trojanowski, J. Q., Stone, D. J., Tienari, P., Shaw, C. E., Traynor, B. J., Marangi G. (ORCID:0000-0002-6898-8882), Logroscino G. (ORCID:0000-0003-1301-5343), Capasso M., Mosca L. (ORCID:0000-0003-4641-0841), Fasano A., Sabatelli M. (ORCID:0000-0001-6635-4985), Zollino M. (ORCID:0000-0003-4871-9519), Conte A., Luigetti M. (ORCID:0000-0001-7539-505X), Lattante S. (ORCID:0000-0003-2891-0340), D'Alfonso S., Siciliano G., Valori M., and Landi F. (ORCID:0000-0002-3472-1389)

Abstract

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS. Using a large-scale genome-wide association study and exome sequencing, we identified KIF5A as a novel gene associated with ALS. Our data broaden the phenotype resulting from mutations in KIF5A and highlight the importance of cytoskeletal defects in the pathogenesis of ALS.

Published
2018

27. Coastal Seaweed Solutions

Author

Vos, B. (author), Foursoff, W. (author), de Bruijn, L. (author), Bruijn, W. (author), Vos, B. (author), Foursoff, W. (author), de Bruijn, L. (author), and Bruijn, W. (author)

Abstract

In recent years, strange phenomena occurred in the Caribbean, Gulf of Mexico and West Africa: a massive tide of sargassum, brown algae, washed ashore causing considerable damage to the local economy and environment. The sargassum mostly consists of Sargassum Natans and Sargassum Fluitans. Old studies concluded that the sargassum came from the Sargasso Sea, however the most recent massive tide of sargassum (named as golden tide) came from an area north of the Amazon river delta. Texas A&M University of Galveston and the University of Florida developed detection systems in cooperation with NASAs satellite images. With the detection system it is possible to track, trace and make forecasts of sargassum landings. Hereby it is possible to act a few days before the sargassum washes ashore, instead of reacting when it landed on the beach already. Most of the problems occur when the massive influxes of sargassum are washed ashore. Currently, the most used harvesting methods on the beach are by use of rakes and wheelbarrows or by using mechanical equipment like a cane loaders and front-end loaders. The beach cleaning methods causes beach erosion and endangers local wildlife. Therefore, harvesting methods at sea are under development. Sargassum is an organic material and can be an useful source for processing. The most used processing methods of sargassum are burying at the beach or using it as a fertiliser. One of the challenges in processing sargassum is working with the unpredictable appearing character of sargassum. The known detection methods have been critically analysed and the most favourable method is developed by Texas A&M University Galveston. This system is applicable on other areas as well and it makes forecasts of sargassum landings. The harvesting methods have also been critically analysed and it can be concluded that the most recommended harvesting method has to be done at sea in combination with a floating barrier. Most of the problems are avoided in this mann, Civil Engineering and Geosciences, Multidisciplinary project

Published
2016

28. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis

Author

Freitag, DF, Butterworth, AS, Willeit, P, Howson, JMM, Burgess, S, Kaptoge, S, Young, R, Ho, WK, Wood, AM, Sweeting, M, Spackman, S, Staley, JR, Ramond, A, Harshfield, E, Nielsen, SF, Grande, P, Lange, LA, Bown, MJ, Jones, GT, Scott, RA, Bevan, S, Porcu, E, Thorleifsson, G, Zeng, LY, Kessler, T, Nikpay, M, Do, R, Zhang, WH, Hopewell, JC, Kleber, M, Delgado, GE, Nelson, CP, Goel, A, Bis, JC, Dehghan, Abbas, Ligthart, Symen, Smith, AV, Qu, LM, van 't Hof, FNG, de Bakker, PIW, Baas, AF, van Rij, A, Tromp, G, Kuivaniemi, H, Ritchie, MD, Verma, SS, Crawford, DC, Malinowski, J, de Andrade, M, Kullo, IJ, Peissig, PL, McCarty, CA, Bottinger, EP, Gottesman, O, Crosslin, DR, Carrell, DS, Rasmussen-Torvik, LJ, Pacheco, JA, Huang, J, Timpson, NJ, Kettunen, J, Ala-Korpela, M, Mitchell, GF, Parsa, A, Wilkinson, IB, Gorski, M, Li, Yunlei, Franceschini, N, Keller, MF, Ganesh, SK, Langefeld, CD, Bruijn, L, Brown, MA, Evans, DM, Baltic, S, Ferreira, MA, Baurecht, H, Weidinger, S, Franke, A, Lubitz, SA, Muller-Nurasyid, M, Felix, Janine, Smith, NL, Sudman, M, Thompson, SD, Zeggini, E, Panoutsopoulou, K, Nalls, MA, Singleton, A, Polychronakos, C, Bradfield, JP, Hakonarson, H, Easton, DF, Thompson, D, Tomlinson, IP, Dunlop, M, Hemminki, K, Morgan, G, Eisen, T, Goldschmidt, H, Allan, JM, Henrion, M, Whiffin, N, Wang, YF, Chubb, D, Houlston, RS, Iles, MM, Bishop, DT, Law, MH, Hayward, NK, Luo, Y, Nejentsev, S, Barbalic, M, Crossman, D, Sanna, S, Soranzo, N, Markus, HS, Wareham, NJ, Rader, DJ, O Reilly, M, Assimes, T, Harris, TB, Hofman, Bert, Franco Duran, OH, Gudnason, V, Tracy, R, Psaty, BM, Farrall, M, Watkins, H, Hall, AS, Samani, NJ, Marz, W, Clarke, R, Collins, R, Kooner, JS, Chambers, JC, Kathiresan, S, McPherson, R, Erdmann, J, Kastrati, A, Schunkert, H, Stefansson, K, Thorsteinsdottir, U, Walston, JD, Tybjaerg-Hansen, A, Alam, DS, Majumder, AA, Di Angelantonio, E, Chowdhury, R, Nordestgaard, BG, Saleheen, D, Thompson, SG, Danesh, J, Freitag, DF, Butterworth, AS, Willeit, P, Howson, JMM, Burgess, S, Kaptoge, S, Young, R, Ho, WK, Wood, AM, Sweeting, M, Spackman, S, Staley, JR, Ramond, A, Harshfield, E, Nielsen, SF, Grande, P, Lange, LA, Bown, MJ, Jones, GT, Scott, RA, Bevan, S, Porcu, E, Thorleifsson, G, Zeng, LY, Kessler, T, Nikpay, M, Do, R, Zhang, WH, Hopewell, JC, Kleber, M, Delgado, GE, Nelson, CP, Goel, A, Bis, JC, Dehghan, Abbas, Ligthart, Symen, Smith, AV, Qu, LM, van 't Hof, FNG, de Bakker, PIW, Baas, AF, van Rij, A, Tromp, G, Kuivaniemi, H, Ritchie, MD, Verma, SS, Crawford, DC, Malinowski, J, de Andrade, M, Kullo, IJ, Peissig, PL, McCarty, CA, Bottinger, EP, Gottesman, O, Crosslin, DR, Carrell, DS, Rasmussen-Torvik, LJ, Pacheco, JA, Huang, J, Timpson, NJ, Kettunen, J, Ala-Korpela, M, Mitchell, GF, Parsa, A, Wilkinson, IB, Gorski, M, Li, Yunlei, Franceschini, N, Keller, MF, Ganesh, SK, Langefeld, CD, Bruijn, L, Brown, MA, Evans, DM, Baltic, S, Ferreira, MA, Baurecht, H, Weidinger, S, Franke, A, Lubitz, SA, Muller-Nurasyid, M, Felix, Janine, Smith, NL, Sudman, M, Thompson, SD, Zeggini, E, Panoutsopoulou, K, Nalls, MA, Singleton, A, Polychronakos, C, Bradfield, JP, Hakonarson, H, Easton, DF, Thompson, D, Tomlinson, IP, Dunlop, M, Hemminki, K, Morgan, G, Eisen, T, Goldschmidt, H, Allan, JM, Henrion, M, Whiffin, N, Wang, YF, Chubb, D, Houlston, RS, Iles, MM, Bishop, DT, Law, MH, Hayward, NK, Luo, Y, Nejentsev, S, Barbalic, M, Crossman, D, Sanna, S, Soranzo, N, Markus, HS, Wareham, NJ, Rader, DJ, O Reilly, M, Assimes, T, Harris, TB, Hofman, Bert, Franco Duran, OH, Gudnason, V, Tracy, R, Psaty, BM, Farrall, M, Watkins, H, Hall, AS, Samani, NJ, Marz, W, Clarke, R, Collins, R, Kooner, JS, Chambers, JC, Kathiresan, S, McPherson, R, Erdmann, J, Kastrati, A, Schunkert, H, Stefansson, K, Thorsteinsdottir, U, Walston, JD, Tybjaerg-Hansen, A, Alam, DS, Majumder, AA, Di Angelantonio, E, Chowdhury, R, Nordestgaard, BG, Saleheen, D, Thompson, SG, and Danesh, J

Abstract

Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1 alpha and IL-1 beta); both alleles increase soluble IL-1Ra protein concentration. We compared effects on inflammation biomarkers of this genetic score with those of anakinra, the recombinant form of IL-1Ra, which has previously been studied in randomised trials of rheumatoid arthritis and other inflammatory disorders. In primary analyses, we investigated the score in relation to rheumatoid arthritis and four cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischaemic stroke, and abdominal aortic aneurysm; 453 411 total participants). In exploratory analyses, we studied the relation of the score to many disease traits and to 24 other disorders of proposed relevance to IL-1 signalling (746 171 total participants). Findings For each IL1RN minor allele inherited, serum concentrations of IL-1Ra increased by 0.22 SD (95% CI 0.18-0.25; 12.5%; p=9.3 x 10(-33)), concentrations of interleukin 6 decreased by 0.02 SD (-0.04 to -0.01; -1,7%; p=3.5 x 10(-3)), and concentrations of C-reactive protein decreased by 0.03 SD (-0.04 to -0.02; -3.4%; p=7.7 x 10(-14)). We noted the effects of the genetic score on these inflammation biomarkers to be directionally concordant with those of anakinra. The allele count of the genetic score had roughly log-linear, dose-dependent associations with both IL-1Ra concentration and risk of coronary heart disease. For people who carried four IL-1Ra-raising alleles, the odds ratio for coronary heart disease was 1.15 (1.08-1.22; p=1.8 x 10(-6)) compared with people who ca

Published
2015

29. Praktijkervaringen met waterberging en natuur in een beekdal : achtergrondrapport : Beerze

Author

Stuijfzand, S., van Ek, R., Klein, J., Sival, F.P., van Manen, H., Eigenhuijsen, E., Hommel, P.W.F.M., Riksen, M.J.P.M., Verbeek, L., Beumer, V., Pelsma, T., Daling, J., and de Bruijn, L.

Subjects
natuurontwikkeling, stroomgebieden, natural areas, nature conservation, Leerstoelgroep Land degradatie en ontwikkeling, hydrology, hydrologie, vegetatie, wateropslag, water quality, ecohydrology, soil, noord-brabant, beekdalen, vegetation, water management, Alterra - Centre for Water and Climate, Wageningen Environmental Research, proefprojecten, ecohydrologie, nature development, brook valleys, waterbeheer, water storage, watersheds, pilot projects, waterkwaliteit, PE&RC, Centrum Ecosystemen, Centre for Ecosystem Studies, bodem, natuurbescherming, natuurgebieden, Land Degradation and Development, Alterra - Centrum Water en Klimaat
Abstract

Hoofddoel van het pilotprogramma is waterbeheerders, terreinbeherende instanties en provincies te ondersteunen in hun activiteiten een koppeling tot stand te brengen tussen waterberging en - buffering en natuurbehoud en -ontwikkeling. Eén van de geselecteerde pilots uit het pilotprogramma ligt langs de Beerze. De Beerze is representatief voor de huidige situatie in veel Brabantse beekdalen: er is sprake van een waterkwantiteitsprobleem, en (tijdelijke) berging van het beekwater in natuurgebieden stuit op problemen, vooral vanwege de (eutrofe) waterkwaliteit. Tegelijkertijd speelt verdroging van natuurgebieden een rol. De pilot Beerze ligt in het traject Logtse Baan - Logtse Velden - Smalbroeken. De onderzoeksperiode van deze pilot besloeg 2004 tot medio 2007

Published
2008

30. Amyotrophic lateral sclerosis: An emerging era of collaboratie gene discovery

Author

Gwinn, K, Corriveau, RA, Mitsumoto, H, Bednarz, K, Brown, RH, Cudkowicz, M, Gordon, PH, Hardy, J, Kasarskis, EJ, Kaufmann, P, Miller, R, Sorenson, E, Tandan, R, Traynor, BJ, Nash, J, Sherman, A, Mailman, MD, Ostell, J, Bruijn, L, Cwik, V, Rich, SS, Singleton, A, Refolo, L, Andrews, J, Zhang, R, Conwit, R, Keller, MA, Lomen-Hoerth, C, Simmons, Z, Newman, DS, Barohn, RJ, Crum, B, Stevens, JC, Simpson, EP, Boylan, KB, McCluskey, L, Bedlack, RS, Bosch, EP, Barkhaus, PE, Dibernardo, A, Caress, JB, Lacomis, D, Pestronk, A, Shefner, JM, Maragakis, NJ, Heitzman, D, Goslin, KL, Jackson, CE, Glass, JD, Mozaffar, T, Bertorini, TE, Chad, DA, Trivedi, JR, Rezania, K, Heiman-Patterson, TD, Gutmann, L, Rosenfeld, J, Brooks, BR, Hayat, G, Chapin, JE, Rudnicki, SA, Harati, Y, Rana, SS, Verma, A, Russell, JA, Pioro, EP, Thornton, CA, Sams, L, Kelly, J, Bayat, E, Kelkar, PM, Shivapour, ET, Scelsa, SN, Walk, D, Peltier, AC, Sachs, G, Belsh, JM, Graves, MC, Thakore, NJ, Brent, HT, Cho, C, Wymer, JP, Lou, JS, Weiss, MD, Carter, GS, Armon, C, Vidic, TR, Bromberg, MB, and Lange, DJ

Abstract

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND). It is currently incurable and treatment is largely limited to supportive care. Family history is associated with an increased risk of ALS, and many Mendelian causes have been discovered. However, most forms of the disease are not obviously familial. Recent advances in human genetics have enabled genome-wide analyses of single nucleotide polymorphisms (SNPs) that make it possible to study complex genetic contributions to human disease. Genome-wide SNP analyses require a large sample size and thus depend upon collaborative efforts to collect and manage the biological samples and corresponding data. Public availability of biological samples (such as DNA), phenotypic and genotypic data further enhances research endeavors. Here we discuss a large collaboration among academic investigators, government, and non-government organizations which has created a public repository of human DNA, immortalized cell lines, and clinical data to further gene discovery in ALS. This resource currently maintains samples and associated phenotypic data from 2332 MND subjects and 4692 controls. This resource should facilitate genetic discoveries which we anticipate will ultimately provide a better understanding of the biological mechanisms of neurodegeneration in ALS.

Published
2007

31. Identifying fragility Fracture Patients

Author

Cranney, A., de Bruijn, L., O'Donnell, S., Martin, J., and Forster, A. J.

Abstract

The 28th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), September 15-19, 2006, Philadelphia, Pennsylvania, USA

Published
2006

32. Atmospheric Monitoring for the Pierre Auger Fluorescence Detector

Author

Mostafa, M. A., Fick, B., Ave, M., Letessier, A., Bertou, X., Deligny, O., Lachaud, C., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Kajita T. Asaoka Y. Kawachi A. Matsubara M. Sasaki M., PIERRE AUGER, Lantz, Simone, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics (astro-ph), FOS: Physical sciences, Astrophysics, Physics::Atmospheric and Oceanic Physics
Abstract

Major uncertainties in the fluorescence energy measurement come from the precision of various atmospheric transmission, air Cerenkov subtraction, light multiple-scattering and cloud corrections. The Auger program for atmospheric monitoring, designed to measure these corrections and to minimize these uncertainties, is summarized in this paper., Four (4) pages, and three (3) EPS figures. Proceedings of the 28th International Cosmic Ray Conference, Universal Academy Press, Inc. Tokyo, Japan, HE (2003) 465-468

Published
2003

33. Shower Studies at around $10^{18}$ eV with the Surface Detector of the Pierre Auger Observatory

Author

P-L, Ghia, Mostafa, M. A., Fick, B., Ave, M., Letessier, A., Bertou, X., Deligny, O., Lachaud, C., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kajita T. Asaoka Y. Kawachi A. Matsubara M. Sasaki M., PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics (astro-ph), FOS: Physical sciences, Astrophysics
Abstract

Three months of data taken by the Engineering Array Surface Detector of the Pierre Auger Observatory have been analyzed with the aim of setting a procedure for the study of showers at E_0 ~ 10^18 eV. We present the results, concerning: (i) the selection procedure and the check of its efficiency; (ii) the event rate and its stability; (iii) the characteristics of such events (i.e., angular direction, energy estimator S(1000), rise time vs core distance, correlation with pressure) showing their consistency with the expectations. The performances of the whole Surface Detector of the Auger Observatory are discussed., Comment: Talk given at 28th International Cosmic Ray Conferences (ICRC 2003), Tsukuba, Japan, 31 Jul - 7 Aug 2003

Published
2003

34. The Anisotropy Search Program For the Pierre Auger Observatory

Author

Clay, W., Ave, M., Letessier, A., Bertou, X., Deligny, O., Lachaud, C., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Kajita T. Asaoka Y. Kawachi A. Matsubara M. Sasaki M., PIERRE AUGER, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics (astro-ph), FOS: Physical sciences, Astrophysics
Abstract

The Pierre Auger Southern Observatory in Argentina has begun taking data as it is being developed up to a final enclosed area of 3000 square kilometres. A key aspect of the project is to provide information on the origin of the highest energy cosmic rays through understanding the arrival directions of those particles. To avoid claims of a spurious anisotropy detection because trials have not been properly accounted, the Auger Collaboration has agreed 'a priori' to the analysis prescription presented here. It specifies the following: 1. The accumulation time for the (future) data set to be analyzed. 2. The anisotropy 'targets', each assigned a chance probability level. 3. The analysis procedure for each trial. A positive result will be claimed for any target search only if its chance probability is less than its assigned level. The levels are chosen so that the total chance probability for one or more positive results is 0.001. Exploratory searches beyond this prescription will be encouraged, but the Auger Collaboration will not assign any confidence level to anisotropies that may be discovered that way. Any such discovery would identify a good target for a prescription to be used with a subsequent Auger data set., 4 pages

Published
2003

35. Calibration of the Pierre Auger fluorescence detector

Author

Roberts, M., Ave, M., Letessier, A., Bertou, X., Deligny, O., Lachaud, C., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kajita T. Asaoka Y. Kawachi A. Matsubara M. Sasaki M., PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Astrophysics (astro-ph), Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics
Abstract

The absolute calibration of an air fluorescence detector (FD) is an important element in correctly determining the energy of detected cosmic rays. The absolute calibration relates the flux of photons of a given wavelength at the detector aperture to the electronic signal recorded by the FD data acquisition system. For the Auger FDs, the primary absolute calibration method uses a diffusive surface which is placed in front of a telescope aperture to uniformly illuminate the telescope field of view with a known light signal. This single-wavelength measurement (375 nm) will be made at intervals of several months until the stability of the telescopes is determined. The relative wavelength dependence of the calibration is determined through independent measurements. The error in absolute calibration at a single wavelength is estimated to be less than 10%. Two other absolute calibration methods are used to provide an independent verification of the primary measurement. The stability of the calibration with time is monitored nightly by a relative calibration system. In this paper we will provide descriptions of the absolute and relative calibration methods used by the Auger air fluorescence observatory. Results from the calibration of the Auger Engineering Array telescopes will also be presented., Comment: 4 pages, no figures. Presented at the 28th International Cosmic Ray Conference

Published
2003
Full Text
View/download PDF

36. Hybrid Performance of the Pierre Auger Observatory and Reconstruction of Hybrid Events

Author

Kick, B., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., J-M, Brunet, J-N, Capdevielle, Cohen, F., Courty, B., Guglielmi, L., J-J, Jaeger, Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Dagoret-Campagne, S., Deligny, O., Lachaud, C., antoine letessier selvon, Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Anchordoqui, L., Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kajita T. Asaoka Y. Kawachi A. Matsubara Y. Sasaki M., PIERRE AUGER, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Lantz, Simone

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics (astro-ph), FOS: Physical sciences, Astrophysics
Abstract

The Pierre Auger Observatory is a``hybrid'' UHECR detector. The surface detector (SD) and air fluorescence detector (FD) of the observatory are designed for observation of cosmic ray showers in coincidence, with a 10% duty cycle. The resulting data are expected to be superior in quality to those of either the SD or FD operating individually. Hybrid operation, triggering, data acquisition, and event reconstruction were successfully demonstrated during the prototype phase of the project. This paper focuses on 75 hybrid events recorded during a four month period of running with the prototype detectors in late 2001 and early 2002. The geometric technique for reconstruction of the hybrid events is described and its advantages over the traditional FD-only method are demonstrated. A lateral distribution for the water Cherenkov signals, derived from these data, is presented., Comment: Talk given at 28th International Cosmic Ray Conferences (ICRC 2003), Tsukuba, Japan, 31 Jul - 7 Aug 2003

Published
2003
Full Text
View/download PDF

37. Atmospheric Monitoring for the Auger Fluorescence Detector

Author

Matthews, J. A. J., Clay, R., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Dagoret-Campagne, S., Deligny, O., Lachaud, C., antoine letessier selvon, Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de l'Accélérateur Linéaire (LAL), Kampert K.H. Heinzelmann G. Spiering C., PIERRE AUGER, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Lantz, Simone

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

38. Layout of the Pierre Auger Observatory

Author

Etchegoyen, A., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A. Clay R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Dagoret-Campagne, S., Deligny, O., Lachaud, C., antoine letessier selvon, Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Kampert K.H. Heinzelmann G. Spiering C., PIERRE AUGER, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Lantz, Simone

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Published
2001

39. Photon/hadron separation with the AUGER Observatory

Author

Billoir, P., Bertou, X., Sylvie DAGORET, Letessier-Selvon, A., Benoît Revenu, Etchegoyen, A., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Tristram, G., Waisbard, J., Boratav, M., Castera, A., Deligny, O., Lachaud, C., Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kamper K.H. Heinzelmann G. Spiering C., PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

40. A PLD Implementation of the Pierre Auger Observatory First Level Trigger

Author

Szadkowski, Z., Nitz, D., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., M-T, Dova, Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A. Clay R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Deligny, O., Lachaud, C., Letessier-Selvon, A., Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Rafert, B., Ruotsala, S., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Kampert K.H. Heinzelmann G. Spiering C., PIERRE AUGER, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Lantz, Simone

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

41. Survey of the Pierre Auger Observatory

Author

M-T, Dova, Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A. Clay R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Dagoret-Campagne, S., Deligny, O., Lachaud, C., antoine letessier selvon, Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Kampert K.H. Heinzelmann G. Spiering C., PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Published
2001

42. The aperture and precision of the Auger surface array

Author

Ave, M., Lloyd-Evans, J., Watson, A. A., Billoir, P., Bertou, X., Dagoret-Campagne, S., antoine letessier selvon, Benoît Revenu, Etchegoyen, A., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Tristram, G., Waisbard, J., Boratav, M., Castera, A., Deligny, O., Lachaud, C., Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Patel, M., Tunnicliffe, V., Walker, P., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Kampert K.H. Heizelmann G. Spiering C, PIERRE AUGER, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Lantz, Simone

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

43. Neutrino sensitivity and backgroung rejection of the Auger Observatory

Author

Letessier, A., Bertou, X., Deligny, O., Lachaud, C., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kampert K.H. Heizelmann G. Spiering C, PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

44. The Auger Fluorescence Detector Electronics

Author

Gemmeke, H., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., M-T, Dova, Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A. Clay R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Dagoret-Campagne, S., Deligny, O., Lachaud, C., antoine letessier selvon, Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Lantz, Simone, Kampert K.H. Heinzelmann G. Spiering C., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Published
2001

45. The aperure, sensitivity and precision of the Auger Fluorescence Detector

Author

Cester, R., Ave, M., Lloyd-Evans, J., Watson, A. A., Billoir, P., Bertou, X., Dagoret-Campagne, S., antoine letessier selvon, Benoît Revenu, Etchegoyen, A., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., Brunet, J. M., Capdevielle, J. N., Cohen, F., Courty, B., Guglielmi, L., Jaeger, J. J., Tristram, G., Waisbard, J., Boratav, M., Castera, A., Deligny, O., Lachaud, C., Genolini, B., Fabrice Lefebvre, Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, D., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Patel, M., Tunnicliffe, V., Walker, P., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R. P., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Luis. Anchordoqui, Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S. Aguirre C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Lantz, Simone, Kampert K.H. Heizelmann G. Spiering C, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), PIERRE AUGER, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2001

46. The Pierre Auger Observatory

Author

Zavrtanik, D., Altmann, E., Alvarez, P., Bauleo, P., Bonifazi, C., Etchegoyen, A., Eusebi, R., Fazzini, N., Ferrero, A., Filevich, A., Reguera, A., Cillis, A., Dova, M. T., Epele, L. N., Grunfeld, C., Mariazzi, A., Martinez, N., Roulet, E., Sciutto, S. J., Veiga, A., Allekotte, I., Avila, G., Masperi, L., Orsaria, M., Rovero, A., Clay, R. W., Dawson, B. R., Pace, R., Riordan, D., Thornton, G. J., Wild, N. R., Boutonnet, C., J-M, Brunet, J-N, Capdevielle, Cohen, F., Courty, B., Guglielmi, L., J-J, Jaeger, Benoît Revenu, Tristram, G., Waisbard, J., Bertou, X., Billoir, P., Boratav, M., Castera, A., Sylvie DAGORET, Deligny, O., Lachaud, C., Letessier-Selvon, A., Genolini, B., Lefebvre, F., Lhenry-Yvon, I., Trung, T. N., Parizot, E., Pouthas, J., Suomijarvi, T., Albert, J. N., Arnault, C., Bilhaut, R., Cordier, A., Cormier, E., Eschstruth, P., Jouniaux, O., Lavigne, B., Oleg Lodygensky, Rypko, J., Martin Urban, Bluemer, H., Bollmann, E., Csabo, T., Grindler, A., Gumbsheimer, R., Heck, D., Hucker, H., Kern, H., Klages, H. O., Kleinfeller, J., Mathes, H. J., Matussek, P., Michel-Piper, I., Risse, M., Schleif, G., Thouw, T., Balzer, M., Berg, R., Bormann, D., Gemmeke, H., Giraud, H., Kleifges, M., Kopmann, A., Kunka, N., Menchikov, A., Osswald, B., Remmel, U., Tscherniakhovski, D., Barenthien, N., Kampert, K. H., Keilhauer, B., Argiro, S., Camin, D. V., Guerard, C., Ambrosio, M., Bernardini, C., Facal, P., Filosofi, R., Fois, M., Matthiae, G., Privitera, P., Salina, G., Borreani, G., Cester, R., Menichetti, E., Pastrone, N., Aramo, C., Cangiano, E., Fonte, R., Insolia, A., Raia, G., Gora, D., Homola, P., Kutschera, M., Ostrowski, M., Wilczynska, B., Wilczynski, H., Arcon, I., Filipcic, A., Zavrtanik, M., Clark, P., Bruijn, L., Knapp, J., Lloyd-Evans, J., Patel, M., Tunnicliffe, V., Walker, P., Watson, A., Arisaka, K., Bonushkin, Y., Kubic, J., Slater, W., Tripathi, A., Brack, J., Hofman, G., Ristinen, R., Harton, J., Sites, J., Warner, D., Wilson, R., Cronin, J. W., Gibbs, K., Albrow, M., Andrews, R., Berman, E., Hoffer, D., Glass, H., Hojvat, C., Mantsch, P., Mazur, P., Spinka, H., Voyvodic, L., Matthews, J. M., Mcewen, M., Meyhandan, R., Darling, J., Dorofeev, A., Nemiroff, B., Nitz, D., Rafert, B., Ruotsala, S., Szadkowski, Z., Trombley, M., Dieterle, B., Matthews, J., Riley, S., Roberts, M., Allison, P., Beatty, J., Coutu, S., Duvernois, M., Cassiday, G., Fick, B., Sommers, P., Anchordoqui, L., Machacek, M., Paul, T., Swain, J., Taylor, L., Akhperjanian, A., Chilingarian, A., Hovsepian, G., Mnatzakanian, E., Sahakian, V., Ter-Antonian, S., Aguirre, C., Bustos, R., Choque, K., Ticona, A., Ticona, R., Velarde, A., Thieu, D. Q., Darriulat, P., Chung, N., Dzung, N. T., Dinh, P. N., Phuong, P. T., Thuan, V. V., Lantz, Simone, Bruni G. Navarria F-L. Pelfer P-G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), PIERRE AUGER, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
2000

47. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

Author

Chiò, A, Schymick, Jc, Restagno, G, Scholz, Sw, Lombardo, F, Lai, S, Mora, G, Fung, H, Britton, A, Arepalli, S, Gibbs, Jr, Nalls, M, Berger, S, Kwee, Lc, Oddone, Ez, Ding, J, Crews, C, Rafferty, I, Washecka, N, Hernandez, D, Ferrucci, L, Bandinelli, S, Guralnik, J, Macciardi, F, Torri, F, Lupoli, S, Chanock, Sj, Thomas, G, Hunter, Dj, Gieger, C, Wichmann, He, Calvo, A, Mutani, R, Battistini, S, Giannini, F, Caponnetto, C, Mancardi, Gl, La Bella, V, Valentino, F, Monsurrò, Mr, Tedeschi, G, Marinou, K, Sabatelli, Mario, Conte, Amelia, Mandrioli, J, Sola, P, Salvi, F, Bartolomei, I, Siciliano, G, Carlesi, C, Orrell, Rw, Talbot, K, Simmons, Z, Connor, J, Pioro, Ep, Dunkley, T, Stephan, Da, Kasperaviciute, D, Fisher, Em, Jabonka, S, Sendtner, M, Beck, M, Bruijn, L, Rothstein, J, Schmidt, S, Singleton, A, Hardy, J, Traynor, Bj, Sabatelli, Mario (ORCID:0000-0001-6635-4985), Chiò, A, Schymick, Jc, Restagno, G, Scholz, Sw, Lombardo, F, Lai, S, Mora, G, Fung, H, Britton, A, Arepalli, S, Gibbs, Jr, Nalls, M, Berger, S, Kwee, Lc, Oddone, Ez, Ding, J, Crews, C, Rafferty, I, Washecka, N, Hernandez, D, Ferrucci, L, Bandinelli, S, Guralnik, J, Macciardi, F, Torri, F, Lupoli, S, Chanock, Sj, Thomas, G, Hunter, Dj, Gieger, C, Wichmann, He, Calvo, A, Mutani, R, Battistini, S, Giannini, F, Caponnetto, C, Mancardi, Gl, La Bella, V, Valentino, F, Monsurrò, Mr, Tedeschi, G, Marinou, K, Sabatelli, Mario, Conte, Amelia, Mandrioli, J, Sola, P, Salvi, F, Bartolomei, I, Siciliano, G, Carlesi, C, Orrell, Rw, Talbot, K, Simmons, Z, Connor, J, Pioro, Ep, Dunkley, T, Stephan, Da, Kasperaviciute, D, Fisher, Em, Jabonka, S, Sendtner, M, Beck, M, Bruijn, L, Rothstein, J, Schmidt, S, Singleton, A, Hardy, J, Traynor, Bj, and Sabatelli, Mario (ORCID:0000-0001-6635-4985)

Abstract

The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 [odds ratio (OR) = 1.17 and 1.18, and P-values = 6.98 x 10(-7) and 1.16 x 10(-6)], were located on chromosome 7p13.3 within a 175 kb linkage disequilibrium block containing the SUNC1, HUS1 and C7orf57 genes. These associations did not achieve genome-wide significance in the original cohort and failed to replicate in an additional independent cohort of 989 US cases and 327 controls (OR = 1.18 and 1.19, P-values = 0.08 and 0.06, respectively). Thus, we chose to cautiously interpret our data as hypothesis-generating requiring additional confirmation, especially as all previously reported loci for ALS have failed to replicate successfully. Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study. Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results