1. Off-label use of midazolam in older inpatients: analysis of prescribing practices in a French hospital (MIDnight study)
- Author
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Bruno Le Dastumer, Mathilde Gourdon, Laurent Teillet, Cécile Pons‐Peyneau, Marie Herr, Hugues Michelon, Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay
- Subjects
Male ,genetic structures ,[SDV]Life Sciences [q-bio] ,Off-label use ,030226 pharmacology & pharmacy ,0302 clinical medicine ,SAFER ,Hypnotics and Sedatives ,heterocyclic compounds ,Pharmacology (medical) ,Practice Patterns, Physicians' ,Geriatrics ,Aged, 80 and over ,Analgesics ,Hospitals ,behavioral disturbances ,3. Good health ,Editorial ,midazolam ,Premedication ,Female ,France ,medicine.symptom ,benzodiazepine ,medicine.drug ,medicine.medical_specialty ,medicine.drug_class ,Sedation ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Drug Prescriptions ,03 medical and health sciences ,Midnight ,medicine ,Humans ,Medical prescription ,Adverse effect ,Aged ,Anesthetics ,Pharmacology ,Benzodiazepine ,Inpatients ,business.industry ,geriatric medicine ,Off-Label Use ,Drug Utilization ,Dilemma ,Anti-Anxiety Agents ,Family medicine ,Emergency medicine ,Midazolam ,business ,030217 neurology & neurosurgery - Abstract
International audience; Midazolam is a short-acting benzodiazepine approved for sedation and anesthesia induction. Recent data suggested that midazolam may also be used in off-label indications such as treatment of behavioral and psychological disturbances in older people. Given the scarcity of published data and a lack of evidence in older people in such indications, midazolam raises concern because it may also cause serious-related adverse events. To provide a better understanding of its real-life use in geriatrics, we examined the prescribing practices of midazolam in French older inpatients. Of the 460 patients aged 65 years and over hospitalized at the time of the study, 21 had a prescription of midazolam (5%) which was mainly prescribed for anxiolysis (n = 12), premedication before painful procedures (n = 5), and agitation (n = 4). Midazolam was often prescribed “as required,” and the median duration of prescription was 6 months. This work results in a better knowledge and information about the use of midazolam in older people. These prescribing practices, which are not anecdotal, also plead for age-specific guidelines for the treatment of behavioral and psychological disturbances.
- Published
- 2020
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