147 results on '"Buono, Frederic"'
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2. G‑EnzyBeads for Biocatalysis Screening Facilitated by Volumetric Dosing.
3. Self-Optimizing Flow Reactions for Sustainability: An Experimental Bayesian Optimization Study.
4. Enhanced Ligand Discovery through Generative AI and Latent-Space Exploration: Application to the Mizoroki-Heck Reaction
5. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation
6. Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation.
7. Ligand-Based Principal Component Analysis Followed by Ridge Regression: Application to an Asymmetric Negishi Reaction.
8. A Slug Flow Platform with Multiple Process Analytics Facilitates Flexible Reaction Optimization.
9. Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction
10. Automated Reactions in Continuous Flow Reactors
11. Optimization of an Azaindazole Series of CCR1 Antagonists and Development of a Semicontinuous-Flow Synthesis
12. Feed Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction
13. Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ
14. Scalable Copper‐Catalyzed Preparation of Imidazopyridinones from Iodopyridinyl Ureas
15. Enantioselective Synthesis of trans-Disubstituted Cyclopropyltrifluoroborate Building Blocks through Ru-Catalyzed Cyclopropanation
16. Recent Advances in Non-Precious Metal Catalysis
17. Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone
18. Scalable copper‐catalyzed preparation of imidazopyridinones from iodopyridinyl ureas.
19. Autonomous Multi‐Step and Multi‐Objective Optimization Facilitated by Real‐Time Process Analytics
20. Recent Advances in Nonprecious Metal Catalysis
21. Carbamoyl Anion Addition to Azirines
22. Novel 1,4-homofragmentation via an [alpha]-lactone
23. A straightforward route to stereodefined functionalized cycloheptanols and cyclooctanols
24. Application of a Preformed Pd-BIDIME Precatalyst to Suzuki–Miyaura Cross-Coupling Reaction in Flow
25. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation
26. Remarkable [beta]-selectivity in the synthesis of [beta]-1-C-arylglucosides: stereoselective reduction of acetyl-protected methyl 1-C-arylglucosides without acetoxy-group participation
27. Preparation of the HIV Attachment Inhibitor BMS-663068. Part 4. Synthesis of the 6-Azaindole Core
28. Effective BI-DIME Ligand for Suzuki-Miyaura Cross-Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X
29. Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement
30. Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor
31. Kinetic evidence for a tetrameric transition state in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes
32. ChemInform Abstract: Efficient Iron-Catalyzed Kumada Cross-Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings.
33. Efficient Iron-Catalyzed Kumada Cross-Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings
34. ChemInform Abstract: Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis.
35. Correction to “Commercial Synthesis of a Pyrrolotriazine-Fluoroindole Intermediate to Brivanib Alaninate: Process Development Directed toward Impurity Control”
36. Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis
37. Development of an Asymmetric Synthesis of a Chiral Quaternary FLAP Inhibitor
38. Development of Multikilogram Continuous Flow Cyclopropanation of N-Benzylmaleimide through Kinetic Analysis
39. Rationalization of anomalous nonlinear effects in the alkylation of substituted benzaldehydes
40. Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.
41. Synthesis of the 6-Azaindole Containing HIV-1 Attachment Inhibitor Pro-Drug, BMS-663068
42. Addressing the Configuration Stability of Lithiated Secondary Benzylic Carbamates for the Development of a Noncryogenic Stereospecific Boronate Rearrangement
43. Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones
44. Commercial Synthesis of a Pyrrolotriazine–Fluoroindole Intermediate to Brivanib Alaninate: Process Development Directed toward Impurity Control
45. ChemInform Abstract: Flow Reactors
46. Selection and Scale-Up Evaluation of an Alternative Route to (−)-(3R,4R)-1-Benzyl-4-(benzylamino)piperidin-3-ol
47. A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor
48. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders
49. Mechanistic Insight into the Palladium‐Catalyzed 1,4‐Oxidation of 1,3‐Dienes to 1,4‐Dicarboxy‐alk‐2‐enes
50. Insights Into Palladium-Catalyzed Cyanation of Bromobenzene: Additive Effects on the Rate-Limiting Step
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