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Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2020-08-03T17:14:06Z No. of bitstreams: 1 Bertha Cristina Bueno Borck.pdf: 4566688 bytes, checksum: 6637cc51e1e1dbcd76745f6d756364cc (MD5) Made available in DSpace on 2020-08-03T17:14:06Z (GMT). No. of bitstreams: 1 Bertha Cristina Bueno Borck.pdf: 4566688 bytes, checksum: 6637cc51e1e1dbcd76745f6d756364cc (MD5) Previous issue date: 2019-11-27 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES Childhood trauma, as a type of early life stress, has been linked to changes in the immune response that may last until adulthood. In this context, interleukin-1β (IL-1β) appears as a proinflammatory cytokine with a central role in innate immunity and stress response. Moreover, considering temperament differences in stress susceptibility and immune dysfunction, studies investigating the complex interaction between these factors are scarce. Therefore, the aim of the present study is to evaluate the moderating role of emotional temperament in the relationship between childhood trauma and serum IL-1β levels in young adults. This is a cross-sectional study composed of a sample of 325 individuals, men and women aged 18 to 35 years, enrolled in a population-based study conducted in the urban area of Pelotas. The study was approved by the UCPel Research Ethics Committee (protocol 2010/15) and all participants signed an informed consent form. For sample characteristics we applied a standard sociodemographic questionnaire, the Child Trauma Questionnaire (CTQ) to assess trauma severity according to total scores and the Affective and Emotional Composite Temperament Scale (AFECTS) for temperament traits evaluation. Blood samples were collected during the interview in the morning and IL-1β dosages were performed on serum samples by the Enzyme-linked immunosorbent assay (ELISA) method. Regarding the statistical analyzes, univariate analysis was used to describe the sample characteristics and the one-way ANOVA test followed by Bonferroni’s post-hoc analysis was used to compare means between groups. Continuous variables with asymmetric distribution were either log-transformed prior to analysis or analyzed by the Spearman correlation test. Moderation analysis was performed by linear regression using the ordinary least squares method to assess the effect of temperament characteristics on IL-1β levels according to the severity of trauma in childhood. The models were adjusted with the following confounding variables: BMI, 10 smoking, gender and medication use. The analyzes mentioned were performed in the SPSS 21.0 statistical package and Python. Values of p≤0.05 were considered statistically significant. Our main results indicated an increase in serum IL-1β levels associated with trauma severity (p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2022-02-09T11:32:21Z No. of bitstreams: 1 Tese - Andressa Jacondino Pires.pdf: 3347950 bytes, checksum: ebab244952568aff39b3d2c2bd9dcbd8 (MD5) Made available in DSpace on 2022-02-09T11:32:21Z (GMT). No. of bitstreams: 1 Tese - Andressa Jacondino Pires.pdf: 3347950 bytes, checksum: ebab244952568aff39b3d2c2bd9dcbd8 (MD5) Previous issue date: 2016-12-15 Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq Introduction: Estimates indicate that 1 in 4 children in the world suffer from some mental disorderand about 10-25% of children have emotional or behavioral problems. Such problems, as well as emotional, conduct, hyperactivity and relationshipproblems are among the most prevalent in childhood. It is also known that mothers of preschool children have a high prevalence of mental disorders and depression is among the most prevalent maternal mental disorders. The presence of mental disorders in the mother may reflect negatively on various aspects of child development according to the duration and severity of symptoms. Aims: To evaluate the impact of maternal depression on development problems in children aged between 4 and 5 years; and to verify the relationship between maternal mental disordersin the puerperal period and current period, and aggressive behavior and oppositional defiant disorder (ODD) among preschoolers. Method: Cross-sectional study with children aged between 4 and 5 years and their mothers; nested in a cohort of adolescent pregnant women that began in 2008. The instruments used were: Mini International Neuropsychiatric Interview (MINI Plus), Strenghs and Difficulties Questionnaire (SDQ) and Child Behavior Checklist (CBCL). Results: The first article, in the multivariate analysis, showed that children of mothers with chronic depression were 6.7 (95% CI 2.3, 19.5) times more likely to present hyperactivity; 2.4 (95% CI 1.1, 5.6) conduct problems; 3.4 (95% CI 1.4, 8.1) hyperactivity and 4.5 (95% CI 1.4, 14.6) relationshipproblems with peers, compared to those whose mothers did not have depression in neither moment. In the second article, aggressive behavior and oppositional defiant disorder (ODD) had a prevalence of 30% and 30.5%, respectively. Both disorders were more prevalent among children whose mothers with current mental disorders received no support and suffered maltreatment during pregnancy and were not living with the child's father. Conclusion: Mothers with current mental disorders are more related to the development of mental disorders in their children, especially the externalizing ones; and the longer the exposure time to maternal depression, the greater the likelihood of the child to present emotional, behavioral, hyperactivity and relationship problems. Introdução: Estimativas apontam que 1 entre 4 crianças no mundo sofre algum transtorno mental e cerca de 10 a 25% das crianças apresentam problemas emocionais ou comportamentais. Tais problemas, assim como problemas de conduta, hiperatividade e de relacionamento estão entre os mais prevalentes na infância. Sabe-se, ainda, que mães de pré escolares apresentam uma alta prevalência de transtornos mentais e a depressão encontra-se entre os transtornos mentais maternos mais prevalentes. A presença de transtornos mentais na mãe pode refletir de forma negativa em vários aspectos do desenvolvimento infantil de acordo com a duração e a severidade dos sintomas. Objetivos: Avaliar o impacto da depressão materna no desenvolvimento de problemas mentais nos filhos com idades entre 4 e 5 anos; e verificar a relação entre transtornos mentais maternos, no período puerperal e atual, e comportamento agressivo e transtorno desafiador opositivo, em pré-escolares. Método: Estudo transversal com crianças entre 4 e 5 anos e suas mães; aninhado a uma coorte de gestantes adolescentes que teve início no ano de 2008. Os instrumentos utilizados foram: Mini International Neuropsychiatric Interview (MINI Plus), Strenghs and Difficulties Questionnaire (SDQ) e Child Behavior Checklist (CBCL). Resultados: O primeiro artigo, na análise multivariada, mostrou que filhos de mães com depressão crônica tiveram 6,7 (IC 95% 2,3; 19,5) vezes mais chance de apresentar hiperatividade; 2,4 (IC 95% 1,1; 5,6) problemas de conduta; 3,4 (IC 95% 1,4; 8,1) hiperatividade e 4,5 (IC 95% 1,4; 14,6) problemas de relacionamento com pares, comparados àqueles cujas mães não tiveram depressão em nenhum momento. Já no segundo artigo, a prevalência de comportamento agressivo foi 30% e transtorno desafiador opositivo foi 30,5%, ambos sendo mais prevalentes em filhos de mães com transtornos mentais atuais, que não se sentiram apoiadas na gestação, que sofreram maus tratos na gestação e que não viviam com o pai da criança. Conclusão: Mães com transtornos mentais atuais apresentam maior relação com o desenvolvimento de transtornos mentais em seus filhos, especialmente os externalizantes; e quanto maior o tempo de exposição à depressão materna, maior a probabilidade da criança apresentarproblemas emocionais, de conduta, hiperatividade e de relacionamento.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-10-04T17:14:34Z No. of bitstreams: 1 CEZAR ARTHUR TAVARES PINHEIRO.pdf: 2225740 bytes, checksum: 65a9a14adfb1aef3b76862e9eb428c57 (MD5) Made available in DSpace on 2016-10-04T17:14:34Z (GMT). No. of bitstreams: 1 CEZAR ARTHUR TAVARES PINHEIRO.pdf: 2225740 bytes, checksum: 65a9a14adfb1aef3b76862e9eb428c57 (MD5) Previous issue date: 2016-06-24 Introduction: Neurocognitive Impairment is frequent in patients infected with Human Immunodeficiency Virus (HIV), secondary to the virus's compromise of the subcortical brain structures. Its manifestations range from asymptomatic impairment to dementia. In addition to cognitive impairment resulting from HIV infection, other factors such as depression are associated with the loss of cognitive functions. Objectives: The aim of this study was to estimate the prevalence of Neurocognitive Impairment in HIV-positive patients in a city in southern Brazil and to establish possible associations with HIV-related and other risk factors. Methods: A cross-sectional study was conducted with HIV-positive outpatients in a specialized care service in the city of Pelotas, southern Brazil. Sociodemographic data and HIV-related information were collected, and all patients underwent psychiatric and neurocognitive evaluations. Results: Paper 1: The prevalence of Neurocognitive Impairment among the 392 patients was 54.1% when tracked using the International HIV Dementia Scale and 36.2% when was associated with a battery of complementary tests. Bivariate analysis suggested an association between Neurocognitive Impairment and gender, age, educational level, depression, current CD4 count (lymphocyte T-4 cells) and lowest CD4 count. The association with depression remained in the Poisson regression (PR=1.96, 95% CI=1.12–3.42). Paper 2: 114 were aged 50 years and above. Characteristics with significant differences between the older and younger HIV-infected patients included skin color, comorbidities, time of diagnosis, duration of use of and adherence toantiretroviral therapy (ART), currently undetectable viral load, and cognitive disorders. Compared with younger patients, older patients were at a higher risk of exhibiting cognitive disorders [OR 2.28 (95 % CI 1.35-3.82, p = 0.002)] and showed increased adherence to ART [OR 3.11 (95 % CI 1.67-5.79, p< 9 0.001)]. Conclusions: The prevalence of cognitive impairment in HIV-positive patients estimated in this study is in accordance with international and Brazilian data. In the present study, the prevalence of these disorders was significantly higher in patients aged 50 years and above. Despite this higher prevalence, older patients exhibited higher adherence to ART and better control of their HIV viral loads. Of the factors analyzed, depression showed the greatest evidence of association with neurocognitive loss. Introdução: Em portadores do Vírus da Imunodeficiência Humana (HIV), alterações neurocognitivas secundárias ao acometimento de estruturas encefálicas subcorticais pelo vírus são frequentes; suas manifestações variam desde alterações assintomáticas até demência. Além das alterações cognitivas decorrentes da infecção pelo HIV, outros fatores estão associados à perda de funções cognitivas nestes pacientes. Entre estes fatores, a depressão. Objetivo: Este estudo teve como objetivo estimar a prevalência de alterações neurocognitivas em pacientes portadores de HIV em uma cidade do sul do Brasil e estabelecer possíveis associações com variáveis relacionadas à infecção pelo vírus e a outros fatores. Métodos: Foi realizado um estudo transversal com portadores do HIV atendidos ambulatorialmente no Serviço de Assistência Especializada (SAE) da cidade de Pelotas, sul do Brasil. Dados sócio-demográficos e informações relacionadas à infecção pelo HIV foram coletados, todos pacientes submeteram-se a avaliação psiquiátrica e neurocognitiva. Resultados: A prevalência de alterações neurocognitivas entre os 392 pacientes foi de 54,1% quando rastreada pela Escala Internacional de Demência por HIV (IHDS) e de 36,2%, quando se associou ao IHDS uma bateria de testes complementares. Artigo1: A análise bivariada sugeriu associação de perda neurocognitiva com sexo, idade, escolaridade, depressão, CD4 atual e nadir de CD4 (menor CD4 que o paciente apresentou). Na Regressão de Poisson manteve-se a associação com depressão (RP=1,96, IC95%=1,12–3,42). Artigo2: 114 pacientes apresentaram idade maior ou igual a 50 anos. As características que foram estatisticamente diferentes nos pacientes com HIV idosos comparados aos portadores mais jovens foram: cor da pele, presença de comorbidades, tempo de diagnóstico, carga 7 viral (CV) indetectável atual, presença de alterações cognitivas, tempo de uso e adesão à Terapia Antirretroviral (TARV). Os pacientes mais velhos apresentaram maior chance de apresentar alterações cognitivas RO 2,29 (IC 95% 1,39-3,78 p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-12-20T19:00:41Z No. of bitstreams: 1 Sandra Lhullier (1).pdf: 820845 bytes, checksum: 4360a70cd874fcf17c790f46b97efa14 (MD5) Made available in DSpace on 2016-12-20T19:00:41Z (GMT). No. of bitstreams: 1 Sandra Lhullier (1).pdf: 820845 bytes, checksum: 4360a70cd874fcf17c790f46b97efa14 (MD5) Previous issue date: 2015-10-01 Objective: Evaluate non adherence to antiretroviral therapy and its associated factors in patients living with HIV / AIDS (PLWHA) treated at a referral Center in Southern Brazil. Methods: The ecological study of retrospective survey was developed in the Specialized Care Service (SAE) in the city of Pelotas. Adherence was assessed using the antiretroviral dispensing record (ARV) for the dispenser unit of drugs (UDM). The sample consisted of patients who withdrew their ARV in the first fifteen days of June 2013 and were followed for one year. The associated factors were evaluated by retrospective data collection from medical records. The mean time between removals was calculated to categorize patients into proper adherence and non-adherence. Patients who had taken ARV higher than the average of 37 days between withdrawals and / or abandoned the withdrawal of ARV were considered non-adherent. Results: 473 patients were eligible for the study. The prevalence of non-adherence was 25.6 %.The variables significantly associated with non-adherence were age < 45 years (p = 0.001), detectable viral load (p < 0.001), absence of clinical comorbidity of ischemic heart disease (p < 0.001). They have tended to increase risk of nonadherence: not present dyslipidemia (p=0. 07) and be in current or initial use scheme with IP (95% IC 0,99 to 1,14). Conclusions: Younger and seemingly healthier patients have higher proportions of non-adherence. Strategies to promote better adherence in this population should be prioritized by PLWHA services. Objetivo: Avaliar à não adesão à terapia antirretroviral e seus fatores associados, em pacientes vivendo com HIV/AIDS (PVHA) atendidos em um centro de referência no sul do Brasil. Métodos: O estudo ecológico de levantamento retrospectivo foi desenvolvido no Serviço de Assistência Especializada (SAE) na cidade de Pelotas-RS. A adesão foi avaliada através do registro de dispensação de antirretrovirais (ARV) pela unidade de dispensadora de medicamentos (UDM). A amostra foi de pacientes que retiraram seus ARV nos primeiros quinze dias de junho de 2013 e acompanhados por um ano. Os fatores associados foram avaliados por coleta de dados retrospectivos de prontuários médicos. Foi calculada a média de tempo entre as retiradas para categorizar os pacientes em adesão adequada e não adesão. Pacientes que apresentaram retiradas de ARV superior à média de 37 dias entre as retiradas e /ou abandonaram a retirada de ARV foram considerados não aderentes. Resultados: Foram elegíveis para o estudo 473 pacientes. A prevalência de não adesão foi de 25,6%. As variáveis significativamente associadas a não adesão foram: idade < 45 anos (p=0,001), carga viral detectável (p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2017-02-14T12:33:58Z No. of bitstreams: 1 JacianaAraujo.pdf: 2059838 bytes, checksum: 74894604be13ceb9ccf8d4d4db402c47 (MD5) Made available in DSpace on 2017-02-14T12:33:58Z (GMT). No. of bitstreams: 1 JacianaAraujo.pdf: 2059838 bytes, checksum: 74894604be13ceb9ccf8d4d4db402c47 (MD5) Previous issue date: 2015-09-29 Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq# #-2555911436985713659# #600 Personality is one of the most important constructs in Psychology and has been receiving increasingly more space among research in this area. The increasing interest regarding the behavioral bases that sustain psychopathological conditions in general and the arrival of the spectral vision of personality disorders has awarded more visibility and relevance to studies with personality traits. Studying the personality traits patterns of the Big Five theory in depressed patients with the intent of finding differential characteristics in relation to Bipolar Affective Disorder and the existence or not of Borderline Personality Disorder comorbidity were the objectives of this study. The first study counted with the presence of 245 patients in current depressive episode, and the second one counted with 149 patients in the same condition. In the first study, sociodemographic, personality traits (NEO-FFI) and mood as well as anxiety disorders (MINI-Plus) data were collected. The groups with Major Depressive Disorder (n= 192) and Bipolar Affective Disorder (n= 62) were compared concerning these characteristics by means of bivariate and multivariate analyses. In the second study, information about Personality Disorders (MCMI-III) was added and comparisons were done as previously described, but between the groups with (n= 40) and without (n= 109) Borderline Personality Disorder comorbidity. The results of the first study pointed to a similar pattern in personality traits distribution between individuals with Major Depressive Disorder and Bipolar Affective Disorder during depressive episode. However, there was significant difference regarding the factor of Agreeableness (p= 0.005, OR= 0.94, IC 95%= 0.90 to 0.98), with higher levels among those with unipolar disorder. In the second study, presence of Borderline Personality Disorder was associated with lower indices of the Conscientiousness factor (p= 0.026, OR= 0.55, IC 95%= 0.33 to 0.93); 12 higher prevalence of suicide risk (p= 0.017, OR= 2.15, IC 95%= 1.14 to 4.05); comorbidity with Cluster A personality disorders (p= 0.010, RC= 2.61, IC 95%= 1.25 to 5.42) as well as with Cluster C ones (p= 0.045, RC= 1.03, IC 95%= 1.00 to 1.07). Data from both studies point that assessing personality traits can be useful, both for differentiation in cases where there is doubt between bipolar and unipolar disorders, as well as for aiding in identifying the presence of Borderline Personality Disorder comorbidity during depressive episodes. A personalidade é um dos construtos mais importantes da Psicologia e tem tido cada vez mais espaço entre as pesquisas da área. O crescente interesse a respeito das bases comportamentais que sustentam os quadros psicopatológicos em geral e o advento da visão espectral dos transtornos da personalidade têm conferido maior visibilidade e relevância aos estudos acerca dos traços de personalidade. Os objetivos desta pesquisa foram centrados na investigação dos traços da teoria Big Five em pacientes deprimidos, pretendendo apontar características diferenciais entre casos de Transtorno Depressivo Maior e Transtorno de Humor Bipolar (no primeiro trabalho) e entre casos com e sem comorbidade entre Transtorno Depressivo Maior e Transtorno da Personalidade Borderline (no segundo trabalho). Os tamanhos amostrais diferiram em função dos objetivos dos estudos. No primeiro trabalho, contou-se com a participação de 245 pacientes em episódio depressivo atual, e no segundo, com 149 pacientes na mesma condição. No primeiro estudo foram coletadas informações, sobre as condições sociodemográficas; sobre os traços de personalidade (NEO-FFI) e sobre transtornos de humor e ansiedade (MINI-Plus). O grupo com Transtorno Depressivo Maior (n= 183) e o grupo com Transtorno de Humor Bipolar (n= 62) foram comparados em função dessas características por meio de análises bivariadas e multivariadas. No segundo estudo foram acrescidas as informações sobre Transtornos da Personalidade (MCMI-III), sendo que as comparações foram feitas como descritas anteriormente, porém, entre os grupos com (n= 40) e sem (n= 109) a comorbidade com Transtorno da Personalidade Borderline. Os resultados do primeiro estudo apontaram um padrão semelhante na distribuição dos traços de personalidade entre os indivíduos com Transtorno Depressivo Maior e Transtorno de Humor Bipolar durante episódio depressivo; contudo, foi 10 encontrada diferença significativa em relação ao fator Amabilidade (p= 0.005, RC= 0.94, IC 95%= 0.90 a 0.98), com níveis mais altos entre os indivíduos com transtorno unipolar. No segundo estudo, a presença do Transtorno da Personalidade Borderline esteve associada a menores índices do fator Conscienciosidade (p= 0.026, RC= 0.55, IC 95%= 0.33 a 0.93); maior prevalência de risco de suicídio (p= 0.017, RC= 2.15, IC 95%= 1.14 a 4.05); comorbidade com os transtornos da personalidade do Cluster A (p= 0.010, RC= 2.61, IC 95%= 1.25 a 5.42) e do Cluster C (p= 0.045, RC= 1.03, IC 95%= 1.00 a 1.07). Os dados de ambos os estudos apontaram que a avaliação dos traços de personalidade pode ser útil, do ponto de vista clínico, tanto para diferenciar casos em que há dúvida diagnóstica, como identificar a presença de comorbidades que podem comprometer diagnóstico e tratamento, caso sejam negligenciadas.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-11-08T15:48:24Z No. of bitstreams: 1 Rochele Castelli.pdf: 1135312 bytes, checksum: 9575cc3f4de5a3d46b326b5164f0e7ff (MD5) Made available in DSpace on 2016-11-08T15:48:24Z (GMT). No. of bitstreams: 1 Rochele Castelli.pdf: 1135312 bytes, checksum: 9575cc3f4de5a3d46b326b5164f0e7ff (MD5) Previous issue date: 2015-02-26 Introduction: Social anxiety disorder is a common disease, which symptoms, including behavioral inhibition, seem to be associated with poor affective care and maternal over control and protection. In addition, it has been shown that children raised by mothers with mental disorders have a poor cognitive and verbal performance. Objectives: Assess the association between social anxiety disorder in young women and their perception of how their own mothers raised them, as well as its association with cognitive and verbal development in their children. Methods: We used data from a cohort study. Teenage mothers, (from 13 to 19 years old) receiving prenatal medical assistance in the national public health system in the urban area of Pelotas, were prospectively followed during their pregnancy and 30 months postpartum. Social anxiety disorder was assed using the Mini Neuropsychiatric Interview Plus (MINI Plus). We used the Portuguese version of the Parental Bonding Instrument (PBI), to measure women’s perception of bond quality with their own mothers, in terms of care and control. We assessed the children’s cognitive and verbal performances using the da Bayley Scales of Infant and Toddler Development- Third Edition at 30 months. Results: We found a significant association between the presence of social anxiety disorder in young women and bond perception with their mothers; prevalence of social anxiety disorder was higher in women who reported their mothers as neglectful (PR 6.39 95% CI 1.2-32.0), and between women who perceived their mother as affectionless controlling (PR 5.57 CI 95% 1.5-19.7) when compared to those who received optimal care. In addition, children of women with social anxiety disorder had a mean score 4.5 points lower in cognitive (IC 95% -7.8; -1.1 p = 0.008) and verbal scales (IC 95% -9.0; -0.5 p = 0.047). Conclusion: Our results suggest that maternal characteristics are important for their children development, and it seems that there is a transmission of internalized models between generations. The women’s bond perception with their mothers seemed to influence the presence of social anxiety disorder, and this affected their own children cognitive and verbal development. To understand the aspects related to the origin and consequences of common disorders, like social anxiety disorder, could help us develop better diagnostic strategies for early intervention and prevention. Introdução: O transtorno de ansiedade social é um transtorno comum e o surgimento de seus sintomas, como sua característica inibição comportamental, parecem estar relacionados tanto a percepção de falta de cuidado e afeto quanto a de excesso de proteção e controle dispensados pelas mães. Por sua vez, sabe-se que mães com transtornos psiquiátricos podem influenciar negativamente o desenvolvimento de seus filhos, afetando seu desempenho em diversas habilidades incluindo cognição e linguagem. Objetivo: Verificar se há associação entre presença de transtorno de ansiedade social em jovens mulheres e a percepção acerca da forma como foram cuidadas por suas mães, além de investigar se a presença do transtorno entre essas jovens tem impacto no desempenho cognitivo e na linguagem de seus filhos. Método: Este trabalho é um recorte de um estudo de coorte. A amostra foi composta por gestantes adolescentes, (com idades entre 13 e 19 anos) que realizaram seu pré natal através do sistema único de saúde e que residiam na zona urbana da cidade de Pelotas. Estas foram acompanhadas durante a gestação e 30 meses após o parto. A presença de transtorno de ansiedade social foi investigada através do Mini Neuropsychiatric Interview Plus (MINI Plus). Para medir percepção acerca da qualidade do vínculo entre mãe e filha em termos de cuidado e controle utilizamos a versão validada para o Português do Parental Bonding Instrument (PBI). Os desempenhos na cognição e linguagem das crianças foram avaliados através da Bayley Scales of Infant and Toddler Development (3ª ed) aos 30 meses. Resultados: Foi encontrada associação significativa entre a forma como as jovens percebiam o vínculo com suas mães e a presença de transtorno de ansiedade social. A chance de apresentar o transtorno foi mais alta entre as mulheres que percebiam sua mãe como negligente (RP 6.39 IC 95% 1.2-32.0) e como pouco afetiva e muito controladora (RP 5.57 IC 95% 1.5-19.7) quando comparadas aquelas cujo cuidado materno era considerado ideal. Também foi significativa a associação entre a presença do transtorno de ansiedade social entre as jovens e pior desempenho de seus filhos nas escalas cognitiva e de linguagem. Filhos de mães com o transtorno apresentaram 4.5 pontos a menos de média comparadas a filhos de mães sem o transtorno nas escalas cognitiva (IC 95% -7.8; -1.1 p = 0.008) e de linguagem (IC 95% -9.0; -0.5 p = 0.047). Conclusão: estes achados sugerem que as caracteristicas maternas são importantes para o desenvolvimento dos filhos e parece haver uma transmissão entre as gerações dos modelos 9 internalizados. A percepção acerca da vinculação dessas jovens com suas mães parece ter influencia na etiologia do transtorno de ansiedade social e, por sua vez, a presença do transtorno entre essas mulheres tem influencia no desempenho de habilidades como cognição e linguagem entre seus filhos. Compreender os aspectos relacionados à origem e às consequencias de transtornos comuns, como o transtorno de ansiedade social, podem resultar em melhores estratégias de diagnóstico e intervenção precoces e trabalhos de prevenção.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-10-31T11:47:19Z No. of bitstreams: 1 Fernanda Kaufmann.pdf: 2463084 bytes, checksum: f42bc94df9b38752179ff7833fe9553c (MD5) Made available in DSpace on 2016-10-31T11:47:19Z (GMT). No. of bitstreams: 1 Fernanda Kaufmann.pdf: 2463084 bytes, checksum: f42bc94df9b38752179ff7833fe9553c (MD5) Previous issue date: 2015-01-28 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Introduction: Cognitive psychotherapies are effective for treating mild to moderate forms of major depressive disorder (MDD). Oxidative stress might contribute to the etiology and progression of MDD. Here, we evaluate the effect of cognitive psychotherapies in symptoms remission and peripheral oxidative stress parameters modulation. Methods: The sample consisted of 49 MDD patients recruited from a larger clinical trial that accesses the effectiveness of cognitive psychotherapies, and 49 control subjects without history of psychiatric disorders recruited from a population-base study which evaluates participant’s temperament and psychiatric disorders in the city of Pelotas, Southern Brazil. Serum oxidative stress parameters were evaluated in the control group and compared to MDD group. MDD Patients enrolled in seven sessions cognitive psychotherapy had oxidative stress parameters analyzed in the baseline, post-treatment and six-month follow-up. Results: Seven sessions of cognitive psychotherapy were able to reduce depressive symptoms evaluated by the Hamilton Rating Scale for Depression (HAMD) at the post-treatment and six-month follow-up compared to baseline (p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2017-02-09T12:26:04Z No. of bitstreams: 1 Marta de Oliveira Gazal.pdf: 1058953 bytes, checksum: a3559296bba6ad1afe42c3d2a3a018d3 (MD5) Made available in DSpace on 2017-02-09T12:26:04Z (GMT). No. of bitstreams: 1 Marta de Oliveira Gazal.pdf: 1058953 bytes, checksum: a3559296bba6ad1afe42c3d2a3a018d3 (MD5) Previous issue date: 2014-02-16 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Chronic stressful stimuli influence disease susceptibility to depression, cardiovascular, metabolic and neurodegenerative disorders. The present work investigated antidepressant and antioxidant properties of the aqueous extract from Cecropia pachystachya in a mouse model of chronic unpredictable stress (CUS). Our results indicated that acute administration of the aqueous extract (AE) from Cecropia pachystachya (200 and 400 mg/kg, p.o.) produced an antidepressant-like effect in the forced swimming test (FST). In addition, chronic treatment with Cecropia pachystachya extract (200 mg/kg, p.o., for 14 days) prevented the depressantlike effect but not the anxiogenic effect induced by CUS. In addition to the behavioural modifications, the 14 days of CUS increased lipid peroxidation in the hippocampus (HP) and prefrontal cortex (PFC) and decreased total thiol content in the HP. Cecropia pachystachya AE administration during CUS protocol was able to prevent the oxidative damage induced by stress. However, no changes were observed in the activity of the antioxidant enzymes superoxide dismutase and catalase in the above cited brain areas after the stress protocol and treatment. Our results suggest that Cecropia pachystachya prevented both depressive behavior and oxidative damage induced by CUS, supporting its neuroprotective potential against behavioral and biochemical dysfunctions induced by chronic stress. Estímulos estressantes crônicos influenciam a susceptibilidade à depressão, doenças cardiovasculares, Metabólicas e neurodegenerativas. O presente trabalho investigou antidepressivos e Propriedades antioxidantes do extrato aquoso de Cecropia pachystachya em um modelo de rato De estresse crônico imprevisível (CUS). Nossos resultados indicaram que a administração aguda O extrato aquoso (AE) de Cecropia pachystachya (200 e 400 mg / kg, p.o.) produziu Efeito antidepressivo no teste de natação forçada (FST). Além disso, o tratamento crônico Com extrato de Cecropia pachystachya (200 mg / kg, p.o., durante 14 dias) evitou a Mas não o efeito ansiogênico induzido pelo CUS. Além do comportamento Modificações, os 14 dias de CUS aumentaram a peroxidação lipídica no hipocampo (HP) e Córtex pré-frontal (PFC) e menor teor de tiol total na HP. Cecropia pachystachya A administração de AE ​​durante o protocolo CUS foi capaz de prevenir o dano oxidativo induzido por estresse. No entanto, não foram observadas alterações na actividade das enzimas antioxidantes Superóxido dismutase e catalase nas áreas do cérebro acima citadas após o protocolo de estresse e tratamento. Nossos resultados sugerem que Cecropia pachystachya impediu tanto o comportamento depressivo E danos oxidativos induzidos pelo CUS, apoiando seu potencial neuroprotetor contra Comportamentais e bioquímicas induzidas pelo estresse crônico.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-09-21T16:12:53Z No. of bitstreams: 1 Andressa Pires.pdf: 780367 bytes, checksum: a817905353295f2fbf63d5cffd90a2d8 (MD5) Made available in DSpace on 2016-09-21T16:12:53Z (GMT). No. of bitstreams: 1 Andressa Pires.pdf: 780367 bytes, checksum: a817905353295f2fbf63d5cffd90a2d8 (MD5) Previous issue date: 2013-12-12 Objective: To investigate the relationship between childhood trauma and obsessive compulsive disorder (OCD) in individuals from 18 to 60 years old, in Pelotas-RS. Method: Case-control nested in a longitudinal study of patients with OCD. The method of matching was used to make cases and controls comparable on gender, age and residing in the same geographical location. To diagnose OCD or any other disorder, MINI Plus was used. The perception of childhood trauma was assessed by CTQ. ASSIST was used to evaluate the use of substances, and only alcohol abuse was used in data analysis. Results: 57 cases and 57 controls were analyzed, 71.9% women with mean age of 35.7 years (SD ± 11.7) and 35.6 years (SD ± 11.7), respectively. There was no difference between the proportions of cases and controls in relation to marital status, psychological or psychiatric treatment, use of psychiatric medication and drug abuse (p< 0.001). In adjusted analysis, OCD remained associated with physical neglect and emotional neglect (p< 0.001). Relationship was found between physical abuse and low socioeconomic class. Conclusion: The identification of early factors, such as childhood trauma, can contribute to the development of prevention methods for OCD Objetivo: Verificar a relação entre trauma na infância e transtorno obsessivo compulsivo (TOC), em indivíduos de 18 a 60 anos, em Pelotas-RS. Método: Casocontrole aninhado a um estudo longitudinal com pacientes com TOC. Foi utilizado o método de pareamento para tornar os casos e os controles comparáveis em relação a sexo, idade e residentes na mesma localização geográfica. Para diagnosticar TOC ou algum outro transtorno foi utilizada a MINI Plus, versão brasileira 5.0.0, baseada nos critérios do DSM –IV-TR. A percepção de trauma na infância foi avaliada através do CTQ. Para avaliar o uso de substâncias utilizou-se o ASSIST, sendo usado para análise dos dados apenas abuso de álcool. Resultados: 57 casos e 57 controles foram analisados, 71,9% das mulheres com idade média de 35,7 anos (DP ± 11,7) e 35,6 anos (DP ± 11,7), respectivamente. Não houve diferença entre as proporções de casos e controles em relação ao estado civil, tratamento psicológico ou psiquiátrico, uso de medicação psiquiátrica e abuso de drogas (p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-09-09T12:00:57Z No. of bitstreams: 1 Augusto Duarte Faria.pdf: 509764 bytes, checksum: abeb590f27771e351e51bf4817e0bfa8 (MD5) Made available in DSpace on 2016-09-09T12:00:57Z (GMT). No. of bitstreams: 1 Augusto Duarte Faria.pdf: 509764 bytes, checksum: abeb590f27771e351e51bf4817e0bfa8 (MD5) Previous issue date: 2013-09-27 Objectives: The aim of this report is to evaluate biological rhythm disruption in a case-­‐ control study nested in a population-­‐based cross-­‐section of people aged 18 to 24 years old. Methods: Caseness was confirmed with the Structured Clinical Interview for DSM-­‐IV (SCID). The Biological Rhythm Interview Assessment in Neuropsychiatry (BRIAN) was used to measure biological rhythm. The severity of depressive symptoms was measured with the Hamilton Depression Rating Scale (HDRS), and to assess the intensity of manic symptoms we utilized the Young Mania Rating Scale (YMRS). The Linear Regression was elaborated to account for potential confounders. Results: The sample consisted of 231 subjects. Of these, 94 were control subjects, 82 had major depression and 55 had bipolar disorder (33 type I and 22 type II). Irregular biological rhythm was associated with a diagnosis of bipolar disorder (40.40±9.78; p0.001) when compared with healthy controls (27.67±6.88). Furthermore, the severity of depression symptoms was highly correlated with the total BRIAN scores (r=0.592; p>0.001). Discussion: This population-­‐based study further reinforces the notion that bipolar disorder and major depression are associated with impairment in biological rhythm. .