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Introdução: O câncer de mama é o tipo mais comum entre as mulheres, com alta incidência após os 50 anos. Fatores como tabagismo, obesidade e predisposição genética influenciam seu desenvolvimento. Embora os avanços no rastreamento e tratamento tenham elevado as taxas de cura, os efeitos adversos físicos e psicológicos dos tratamentos ainda comprometem significativamente a qualidade de vida das pacientes. Objetivo: Investigar os efeitos do treinamento resistido (TR) isolado ou combinado com o treinamento aeróbio em mulheres sobreviventes de câncer de mama. Métodos: Trata-se de uma revisão integrativa com abordagem qualitativa, de natureza descritiva, exploratória e opinativa da literatura. Os acervos eletrônicos Periódicos CAPES, Biblioteca Virtual em Saúde (BVS) e Pub Med foram consultados para buscar estudos de intervenção que relacionavam treinamento resistido/aeróbio com mulheres sobreviventes de câncer de mama, publicados entre 2012 e 2023, com faixa etária de 40 a 80 anos e escritos em português ou inglês. Resultados e Discussão: O TR, isolado ou combinado com treinamento aeróbio, é eficaz para melhorar vários aspectos em mulheres sobreviventes de câncer de mama, incluindo força muscular, redução da fadiga, qualidade de vida e aspectos psicossociais. Conclusão: O TR é seguro e flexível, permitindo combinação de exercícios para atender preferências e limitações individuais, abordando domínios fisiológicos não alvo de outros exercícios.

Abstract High fructose consumption has been recognized as a potential risk factor for increased incidence of cardiovascular disease, and diabetes. Some lines of evidence support endothelial dysfunction (ED) as a possible underlying mechanism linking insulin resistance and hypertension. However, there is little information on the vascular response to vasoactive mediators after the high-fructose intaking (HFI). In this study, swiss mice had access to fructose-water solution (at 30% w/v) ad libitum for ten consecutive weeks. After this period, the vascular reactivity was assessed by the analyses of the variations in mean arterial pressure induced by either angiotensin II (Ang II) or sodium nitroprusside (SNP). Results showed that HFI induced i) an increased response to the vasoconstrictive and hypertensive agent Ang II, and ii) a decreased response to the vasodilating and hypotensive agent SNP. Western blot analysis revealed that such events were paralleled by higher Ang II type 1 receptor (AT1) and lower guanylate cyclase (GC-β1) enzyme densities in the mesenteric arterial bed (MAB). The present study demonstrated that HFI leads to an impaired response to vasoactive substances and, consequently, to ED in MAB.

Background: Despite the current data on morbidity and mortality, a growing number of patients with a diagnosis of cancer survive due to an early diagnosis and advances in treatment modalities. This study aimed to compare the quality of life and coping strategies in three groups of patients with cancer and identify associated clinical and sociodemographic characteristics. Methods: A comparative study was conducted with outpatients at a public hospital in the state of São Paulo, Brazil. The 300 participants were assigned to three groups: patients in palliative care (Group A), patients in post-treatment follow-up with no evidence of disease (Group B), and patients undergoing treatment for cancer (Group C). Data collection involved the use of the McGill Quality of Life Questionnaire and the Ways of Coping Questionnaire. No generic quality-of-life assessment tool was utilized, as it would not be able to appropriately evaluate the impact of the disease on the specific group of patients receiving palliative care. Results: Coping strategies were underused. Participants in the palliative care group had poorer quality of life, particularly in the psychological well-being and physical symptom domains. Age, currently undergoing treatment, and level of education were significantly associated with coping scores. Age, gender, income, and the absence of pharmacological pain control were independently associated with quality-of-life scores. Moreover, a positive association was found between coping and quality of life. Conclusion: Cancer patients in palliative care generally report a lower quality of life. However, male patients, those who did not rely on pharmacological pain control, and those with higher coping scores reported a better perception of their quality of life. This perception tended to decrease with age and income level. Patients currently undergoing treatment for the disease were more likely to use coping strategies. Patients with higher education and quality-of-life scores also had better coping scores. However, the use of coping strategies decreased with age.

BackgroundDengue, Zika, and chikungunya, whose viruses are transmitted mainly by Aedes aegypti, significantly impact human health worldwide. Despite the recent development of promising vaccines against the dengue virus, controlling these arbovirus diseases still depends on mosquito surveillance and control. Nonetheless, several studies have shown that these measures are not sufficiently effective or ineffective. Identifying higher-risk areas in a municipality and directing control efforts towards them could improve it. One tool for this is the premise condition index (PCI); however, its measure requires visiting all buildings. We propose a novel approach capable of predicting the PCI based on facade street-level images, which we call PCINet.MethodologyOur study was conducted in Campinas, a one million-inhabitant city in São Paulo, Brazil. We surveyed 200 blocks, visited their buildings, and measured the three traditional PCI components (building and backyard conditions and shading), the facade conditions (taking pictures of them), and other characteristics. We trained a deep neural network with the pictures taken, creating a computational model that can predict buildings' conditions based on the view of their facades. We evaluated PCINet in a scenario emulating a real large-scale situation, where the model could be deployed to automatically monitor four regions of Campinas to identify risk areas.Principal findingsPCINet produced reasonable results in differentiating the facade condition into three levels, and it is a scalable strategy to triage large areas. The entire process can be automated through data collection from facade data sources and inferences through PCINet. The facade conditions correlated highly with the building and backyard conditions and reasonably well with shading and backyard conditions. The use of street-level images and PCINet could help to optimize Ae. aegypti surveillance and control, reducing the number of in-person visits necessary to identify buildings, blocks, and neighborhoods at higher risk from mosquito and arbovirus diseases.

Abstract Background Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, and liver tissue from damage in a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, and its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, and blood markers such as urea, creatinine, AST, ALT, CPK, CPR, and NOx levels were determined. Results We showed that DOX has a significant effect on renal blood flow and on urea, creatinine, AST, ALT, CPK, and NOx. Morphologically, DOX reduced the inflammatory process in the liver tissue. Conclusions We conclude that DOX protects the liver and kidney against injury and dysfunction in a HS model and could be a strategy to reduce organ damage associated with ischemia-and-reperfusion injury.

Interindividual variation in drug efficacy and toxicity is a significant problem, potentially leading to adverse clinical and economic public health outcomes. While pharmacogenetics and pharmacogenomics have long been considered the primary causes of such heterogeneous responses, pharmacomicrobiomics has recently gained attention. The microbiome, a community of microorganisms living in or on the human body, is a critical determinant of drug response and toxicity. Factors such as diet, lifestyle, exposure to xenobiotics, antibiotics use, illness, and genetics can influence the composition of the microbiota. Changes in the intestinal microbiota are particularly influential in drug responsiveness, especially in cancer chemotherapy. The microbiota can modulate an individual’s response to a drug, affecting its bioavailability, clinical effect, and toxicity, affecting treatment outcomes and patient quality of life. For instance, the microbiota can convert drugs into active or toxic metabolites, influencing their efficacy and side effects. Alternatively, chemotherapy can also alter the microbiota, creating a bidirectional interplay. Probiotics have shown promise in modulating the microbiome and ameliorating chemotherapy side effects, highlighting the potential for microbiota-targeted interventions in improving cancer treatment outcomes. This opinion paper addresses how environmental factors and chemotherapy-induced dysbiosis impact cancer chemotherapy gastrointestinal toxicity.

Objetivo: Identificar en la literatura científica el rol de equipo de enfermería en los equipos de respuesta rápida en la atención del paro cardiorrespiratorio, en las diferentes regiones continentales. Metodología: Se realizó una revisión integrativa de la literatura con búsqueda en las bases de datos PubMed, Web of Science, Scopus, Lilacs y CINAHL, utilizando los descriptores: equipo de respuesta rápida, cuidados de enfermería, atención de enfermería, equipo multiprofesional, paro cardíaco y enfermería. Se incluyeron estudios en portugués, inglés y español, publicados entre 2010 y 2020, que describieran el papel de la enfermería en los equipos de respuesta rápida. Resultados: La muestra comprendió 6 artículos y abarcó prácticamente la mitad del continente americano, específicamente en América del Norte. El papel de los enfermeros en los equipos de respuesta rápida incluye dos dimensiones: la asistencial, que abarca la atención directa al paciente crítico hasta la llegada del profesional médico, y la administrativa, relacionada con actividades de educación continua, elaboración de protocolos clínicos y comunicación entre sectores, equipos y gestión de la asistencia. Conclusiones: El equipo de enfermería, en los equipos de respuesta rápida, desarrolla el papel de coordinador de múltiples actividades asistenciales y de gestión para los pacientes hospitalizados con signos de empeoramiento clínico y que necesitan intervención inmediata.

ABSTRACT Objective: To understand the meaning attributed by women with physical disabilities to the health care received and expected during labor and delivery. Methods: Qualitative study, based on Social Network Theory, conducted through an online workshop in April 2022, with the participation of six women with physical disabilities. Data, collected through the focus group technique, underwent thematic content analysis with the assistance of the IRaMuTeQ tool. Results: Three thematic categories emerged: Challenges experienced during pregnancy; The experience within the maternity ward; and, The importance of social networks. The assistance provided by healthcare professionals sometimes differed between what was expected and what was received by women with physical disabilities during labor and delivery. Final Considerations: Experiences were predominantly negative, resulting from inappropriate professional conduct due to ableist attitudes. Support from members of social networks is crucial for preventing stressors.

RESUMO Este artigo discute a importância da água na vida cotidiana de mulheres que vivem em favelas e ocupações da cidade do Rio de Janeiro, pensando a água como bem vital, imprescindível para as relações de cuidados. O texto articula o debate sobre infraestrutura urbana com o de cuidado para pensarmos sobre os modos generificados e racializados de fazer cidade. Por meio de pequenos eventos domésticos, de diálogos que as autoras tiveram com suas interlocutoras ou de descrições etnográficas mais longas, o trabalho mostra como a água carrega a força do ordinário e é um dos objetos que permite ver a potência e a vulnerabilidade que a vida diária carrega em termos de gênero, classe e raça. Descreve-se o trabalho das mulheres nos processos de fazer cidade ao relacionar a precariedade de acesso à água com a subalternidade do trabalho do cuidado como aspectos coexistentes que visibilizam as condições de profunda desigualdade dos moradores de periferias.

Resumo Perante diagnóstico e tratamento de doença grave em crianças, incluindo a oncológica, os pais, em especial as mães, tendem a assumir integralmente as demandas de cuidados, necessitando desenvolver estratégias de enfrentamento situacional. Nesse sentido, este estudo descritivo e transversal objetivou identificar o uso do coping religioso/espiritual em cuidadores informais de crianças com leucemia linfoide aguda mediante aplicação da escala de coping religioso/espiritual breve. Participaram 30 cuidadores informais, que apresentaram coping religioso/espiritual alto (média=3,90; Dp=0,34) na modalidade positiva (média=3,67; Dp=0,48). Por fim, identificou-se que as mães utilizam coping religioso/espiritual para lidar com a demanda de cuidados a elas imposta, vinculada à condição de saúde da criança. Com isso, reforça-se a possibilidade de utilizar a espiritualidade e/ou a religiosidade como indicadores de bem-estar físico e mental, visto que a qualidade dos cuidados prestados está intimamente relacionada à saúde de quem cuida.

Abstract Objective To investigate the association between burnout and quality of life among nursing staff at intensive care units during the new coronavirus pandemic and identify the influence of sociodemographic variables. Methods A cross-sectional study was conducted with 109 nursing staff members at intensive care units of a public hospital in Brazil. Data collection involved the administration of a sociodemographic questionnaire as well as the WHOQOL-Bref and Oldenburg Burnout Inventory. Results The participants presented a high state of burnout and a low score in the physical domain of the quality-of-life instrument. Men (p = 0.037), income (p = 0.011) and burnout (p

Este capítulo tem como foco o projeto Sounds of Intent, que visa mapear o desenvolvimento musical de jovens com as necessidades mais complexas. A partir de 2002, a equipe de pesquisa trabalhou com um grupo de profissionais que atuavam na área - musicoterapeutas, educadores musicais e outros profissionais - para desenvolver descrições precisas e interpretações compartilhadas das diferentes formas e níveis de engajamento musical que observaram entre crianças e jovens com necessidades educacionais especiais. O referencial teórico desenvolvido pela equipe é discutido nessa tradução.

The isomeric mixture of alpha and beta amyrin (AMY), present in the resin of Protium heptaphyllum, is popularly used as anti-inflammatory and anti-ulcer. The literature has been demonstrating pharmacological activities of these triterpenes in the central and peripheral nervous systems, and in the gastrointestinal and immunological systems. This study traces a toxicological profile of amyrin, aiming to provide information that may clarify its safety. Nine female Wistar rats (170 to 200 g) were divided into three groups of three animals each (control, amyrin 300 and amyrin 2000 mg kg-1, p.o.), which were evaluated by protocols preconized by the Organization for Economic Co-operation and Development (OECD). Open field Test and Malone Hippocratic Screening Scale were performed. AMY, mostly at 2000 mg kg-1, reduced the number of crossings by 57% vs. saline (22.67 ± 2.40) and the number of rearing by 53% vs. saline (42.67 ± 2.96), but increased the number of grooming by 26% vs. saline (1.66 ± 0.33). AMY (2000 mg kg-1) increased the serum glucose by 77% vs. saline (126.70 ± 4.33 mg dL-1), triglycerides by 50% vs. saline (78.67 ± 2.18 mg dL-1) and uric acid by 65% vs. saline (0.73 ± 0.03 mg dL-1). AMY induced vascular congestion and hemorrhage in the liver, spleen and cerebral cortex. Renal changes (cellular damage, inflammatory infiltrate, tubular protein deposition and glomeruli atrophy) were also seen. In conclusion, AMY decreased rat locomotor activity, caused minor biochemical changes, and altered the morphology of the kidney. The present study may contribute to deepen the knowledge about the safety of AMY, aiming the development of a novel pharmacological product.

Resumo O artigo analisa a figura da "novinha" enquanto categoria articuladora de idade e comportamento, na interface com outros marcadores sociais da diferença, tais como gênero, território, raça e sexualidade. A partir de etnografia realizada em duas favelas do Rio de Janeiro, discuto as tensões que pesam sobre as "novinhas": o uso das roupas curtas, a "afronta", o "medo de engravidar", as acusações sobre usurpação de relações afetivas e a provocação de homens mais velhos. Ao final, apresento de que maneira a relação entre performance e enquadramento evidencia um campo de tensões mais amplo relativo à sexualidade feminina que atualiza um imaginário racializado e colonial acerca de meninas negras e moradoras de favela.

O conhecimento sobre a tolerância ao estresse hídrico é importante para escolher adequadamente o capim conforme às diversas condições edafoclimáticas. Diante disso, o objetivo com esta pesquisa foi verificar a tolerância de híbridos de Brachiaria spp. ao estresse por déficit hídrico e alagamento. O experimento ocorreu em casa de vegetação, em delineamento experimental inteiramente casualizado, com doze tratamentos, em esquema fatorial 4x3, e três repetições. Os tratamentos adotados foram quatro capins, sendo três híbridos de braquiária (Camello, Cayana, Cayman) e B. humidicola cv. Llanero, que foram submetidos a três condições hídricas (déficit hídrico, sem estresse hídrico e alagamento). As gramíneas foram submetidas ao estresse hídrico por 47 dias e neste período foram realizadas duas avaliações. Para todos os capins, o déficit hídrico acarretou redução no número de perfilhos e o déficit hídrico e o alagamento promoveram redução no número de folhas, com maior impacto para o déficit hídrico. O alagamento não comprometeu a massa de forragem da Brachiaria humidicola cv. Llanero, o que demonstrou a tolerância deste capim a este estresse hídrico. Para todos os híbridos, houve a redução da produção de massa de forragem quando submetidos ao estresse hídrico (déficit e alagamento). O deficit hídrico promoveu menor massa de forragem que o alagamento para todos os híbridos estudados, com exceção do Cayana, que foi afetado de modo igual pelo déficit hídrico e alagamento. O déficit hídrico reduziu a massa de raízes de todos os capins, enquanto o alagamento reduziu a massa de raízes dos capins Camello e Cayana. Observou-se que a Brachiaria humidicola cv. Llanero e o capim Cayman apresentam maior tolerância ao alagamento, visto que nesta condição não houve redução na massa de raízes. Por isso, nenhum dos híbridos tem tolerância ao déficit hídrico e o Cayman é o híbrido com maior tolerância ao alagamento.

Abstract Background Assessment tools are commonly used in different fields of health to assist in the diagnosis, the evaluation of the response to treatment, the measurement of quality of life and the establishment of the prognosis. Objectives Translate, culturally adapt and perform the psychometric validation of the Somatic Symptom Scale (SSS-8) for use in the Brazilian population. Methods Cross-cultural adaptation followed a combination of guidelines and for psychometric evaluation a sample of 300 patients was recruited. All recommended measurement properties by the Consensus-based Standards for the selection of health status Measurement Instruments were evaluated, including analysis by an expert committee and analysis by the target public. The Skindex-16 was used for the evaluation of convergent validity and Cronbach’s alpha was used for the determination of the internal consistency of the translated version of the SSS-8. Results The final version received approval from five experts and the agreement index was 100% for all items. During the pretest, the scale was administered to 300 patients with psoriasis and none of the items needed to be altered. A moderate correlation was found between the Skindex-16 and SSS-8-BRA. In the analysis of internal consistency, Cronbach’s alpha for the SSS-8-BRA was 0.81. Conclusion The SSS-8 is a valid and reliable tool for the assessment of somatic symptoms in the Brazilian population.

A pandemia chegou ao Brasil no início do ano de 2020, exigindo assim, que as aulas fossem ministradas em diversos formatos, entre eles, o uso de plataformas para acompanhamento e aulas por meio de videoconferência. As aulas passaram de presenciais em salas físicas para salas on-line. Entretanto, dentre as diversas dificuldades encontradas, uma causou grandes críticas dos professores, a “não abertura de câmeras” pelos estudantes. Desse modo, o presente estudo tem como objetivo compreender a visão dos estudantes no que se refere a abertura de câmeras no decorrer do ERE (Ensino Remoto Emergencial) e identificar quais as principais causas não desveladas para a grande quantidade de estudantes não abrirem as câmeras no decorrer das aulas. O estudo em questão, de abordagem qualitativa, teve como fonte de dados um questionário on-line enviado de forma conveniente a estudantes do Ensino Superior de várias instituições brasileiras (públicas e privadas) por meio da plataforma Google Formulários. Ao todo, responderam o instrumento 269 estudantes. Os resultados apontam diversas justificativas para a não abertura das câmeras como: falta de privacidade, ambiente inadequado, falta de obrigatoriedade e equipamentos e rede inadequados para o ERE. Os dados revelam que os estudantes tiveram muitas dificuldades nesse formato de estudo, e muitas delas não se referem exatamente às especificidades das aulas remotas síncronas mediadas pelas tecnologias, mas pelas próprias condições de vida dos estudantes. Assim, a análise aponta que as mudanças da sala de aula presencial para a sala virtual implicaram não só em mudanças pedagógicas ou estratégicas didáticas, mas em alterações profundas no modo de ser e estar em uma sala on-line.

Nesta entrevista, Vilson foi convidado a recordar e refletir sobre a sua trajetória no Brasil e nos Estados Unidos, como aluno, músico, professor e pesquisador com deficiência visual. Temas como tecnologias aplicadas no ensino e aprendizagem em música) musical e inclusão, interação, autonomia, acessibilidade recíproca, educação musical especial e acessibilidade cultural foram abordados nesta entrevista.

Nenéu Liberalquino é maestro e diretor artístico da Banda Sinfônica do Recife, além de violonista, compositor, arranjador e professor. Tem ministrado vários cursos nas áreas de arranjo, harmonia erudita e jazzística. Violonista autodidata, desenvolveu sua técnica adaptada para que pudesse tocar, mantendo-se fiel ao estilo brasileiro de tocar violão. Isso tornou-se necessário, em função de sua deficiência física decorrente da poliomielite e sarampo contraídos aos quatro anos.

Abstract Objective To compare the psychometric performance of a generic and specific instruments in assessing melasma-related quality of life. Methods A cross-sectional study was conducted with 150 patients with melasma attending an outpatient dermatology clinic of a public hospital in São Paulo state, Brazil. Data were collected using a questionnaire containing sociodemographic and clinical data as well as the generic WHOQOL-BREF, and the dermatological-specific Skindex-16 and HRQ-Melasma. Results The overall internal consistency of the domains of the three instruments was ≥ 0.7. A strong positive correlation was identified between the Skindex-16 and HRQ-Melasma domains (0.68-0.78). Item-response theory showed that most Skindex-16 and HRQ-Melasma domains were more informative than WHOQOL-BREF. Conclusion The three instruments for assessing QOL tested presented good psychometric performance, with satisfactory internal consistency values. Only the two dermatological instruments, however, demonstrated a strong correlation between the domains that assess social, emotional, and functional aspects of QOL, indicating that both were able to identify impairments in other QOL dimensions in addition to the physical domain.

Grass regrowth can reduce root mass, delaying reestablishment and grazing periods by reducing the nutrient absorption from the soil by plants. This study aimed to determine the optimal intervals for harvest and nitrogen fertilization in Urochloa brizantha cv. BRS Piatã and Megathyrsus maximuscv. BRS Quênia, as well as to investigate whether the flexibility of the fertilization time is related to the accumulation of water-soluble carbohydrates (WSC) and nitrogen in the roots. The experiment was conducted in a greenhouse, using a completely randomized design, with five treatments (nitrogen fertilization after harvest: 0, 2, 4, 6 and 8 days) and ten replicates. The nitrogen fertilization time linearly reduced the forage and root mass for the BRS Piatã, but had no effect on the BRS Quênia guinea grass. For the BRS Piatã, the WSC and starch concentrations in the roots showed a quadratic response, decreasing from harvest to day 2 and increasing until the day 8. However, the delayed fertilization led to a linear reduction in the root nitrogen content. The nitrogen fertilization time had a quadratic effect on the WSC concentration for the BRS Quênia roots. For the BRS Piatã, the nitrogen fertilization immediately after harvest improves the forage and root masses, WSC and nitrogen reserves. In contrast, the BRS Quênia exhibited a greater flexibility, concerning the nitrogen fertilization time. The interval between harvest and nitrogen fertilization is primarily depended on root mass, which influences the nitrogen accumulation in the roots.

O objetivo do presente estudo foi apontar as compensações comuns durante a realização do Overhead Squat (OS) em atletas de rugby, a fim de indicar exercí­cios corretivos para estas compensações A amostra foi composta por 28 atletas de rugby, sendo 19 homens (21,11 + 4,54 anos) e 9 mulheres (26,37 + 6,33 anos), com treinamento regular e sem lesões pregressas. O agachamento foi realizado, de forma padronizada, na maior amplitude de movimento possí­vel, mantendo os cotovelos estendidos com o bastão mantido acima da cabeça e a parte superior do corpo elevada o tempo todo, o exercí­cio foi filmado nos planos frontal e sagital. Para avaliar o movimento foram observadas as seguintes regiões corporais no plano frontal: pés e joelhos; e no sagital: calcanhares, quadris/coxas, tronco e braços. A pontuação foi atribuí­da da seguinte forma: 0 para execução falha ou não adequada e 1 para execução adequada, tendo como pontuação máxima 6 pontos. Os resultados indicam que os sujeitos apresentaram mediana de 4 pontos, sendo que dois atletas obtiveram pontuação máxima. Ademais, 84,7% da amostra apresentou ao menos 2 compensações, 67,9% apresentam inclinação do tronco fora da base de sustentação e 53,6% apresentam incapacidade de chegar a uma posição de coxa paralela ao solo. Os resultados indicam que a capacidade limitada de mobilidade no tornozelo e estabilidade de joelhos pode comprometer a profundidade do agachamento, assim como o encurtamento dos gastrocnêmicos e o déficit de força em glúteo máximo induzindo à inclinação excessiva do tronco durante a realização do OS.

O rugby é caracterizado pelo contato fí­sico intenso, exigindo força e estabilidade central. Déficits na estabilidade central resultam em técnicas ineficientes, deixando o atleta suscetí­vel a lesões. O objetivo do presente estudo foi analisar os efeitos de um programa de estabilização central sobre a flexibilidade, estabilidade do CORE e equilí­brio em atletas de rugby feminino. Participaram do estudo 10 atletas, submetidas a um programa de exercí­cios de 10 sessões. Como instrumentos de avaliação foram utilizados: Eight Hop Test (EHT) e Side Hop Test (SHT) para o equilí­brio; abaixamento da perna estendida para a estabilidade do CORE e o teste de sentar e alcançar no banco de Wells para a flexibilidade. Foram realizadas três avaliações: a primeira um dia antes do iní­cio do protocolo de exercí­cios, a segunda no dia seguinte a última sessão do programa e a terceira no oitavo dia após o término da intervenção. As atletas apresentaram melhora no EHT após a intervenção (p

An overview of the total Arabidopsis thaliana transcriptome, described previously by our research group, pointed some noncoding RNA (ncRNA) as participants in the restoration of hair-root phenotype in A. thaliana rhd6 mutants, leading us to a deeper investigation. A transcriptional gene expression profiling of seedling roots was performed aiming to identify ncRNA responsive to nitric oxide (GSNO) and auxin (IAA), and their involvement in root hair formation in the rhd6 null mutant. We identified 3,631 ncRNAs, including new ones, in A. thaliana and differential expression (DE) analysis between the following: 1) GSNO-treated rhd6 vs. untreated rhd6, 2) IAA-treated rhd6 vs. untreated rhd6, 3) GSNO-treated rhd6 vs. IAA-treated rhd6, and 4) WS-2 vs. untreated rhd6 detected the greatest number of DE genes in GSNO-treated rhd6. We detected hundreds of in silico interactions among ncRNA and protein-coding genes (PCGs), highlighting MIR5658 and MIR171 precursors highly upregulated in GSNO-treated rhd6 and wild type, respectively. Those ncRNA interact with many DE PCGs involved in hormone signaling, cell wall development, transcription factors, and root hair formation, becoming candidate genes in cell wall modulation and restoration of root hair phenotype by GSNO treatment. Our data shed light on how GSNO modulates ncRNA and their PCG targets in A. thaliana root hair formation.

ABSTRACT Objective: To understand the hypoalgesic effect of exercises in obese patients with low back pain. Methods: From the methodological point of view, this is a systematic review study supported by the PRISMA guidelines (2020). Only clinical trials with defined eligibility criteria were included and the methodological evaluation was carried out using the Risk of Bias 2.0 (RoB 2.0) tool. Results: Four clinical trials were found, which underwent an assessment of risk of bias and were mostly categorized as moderate risk of bias or with some concerns. Conclusions: Moderate-intensity interval training (MIIT), high-intensity interval training (HIIT), and total resistance or lumbar spine extension exercises were shown to be effective for pain control, quality of life, and functional performance in obese individuals. On the other hand, the exercises alone did not produce a decrease in body composition. Level of evidence I; Systematic review.

Abstract Background: Health-related quality of life assesses how diseases affect the daily life of people; there are several generic instruments for this assessment in dermatology. Skindex was created in 1996; it is a multidimensional instrument, aiming to encompass some psychological and social aspects not yet addressed by other questionnaires. Among its versions (Skindex-29, 16, and 17), Skindex-17 had not been validated in Brazil. Objectives: To validate Skindex-17 for use in Brazilians with dermatological diseases. Methods: This was a methodological, cross-sectional, and prospective study of 217 patients attended at the Dermatology Service Outpatient Clinic, Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (Botucatu, SP, Brazil), from December 2017 to September 2019. The following were evaluated: content validity, filling time, internal consistency, dimensional structure, concurrent validity (DLQI), temporal stability, and responsiveness. Results: The sample consisted of 71% women, mean age (SD) of 45 (16) years; phototypes II−IV accounted for 95% of the cases. Cronbach's alpha coefficients were 0.82 and 0.93 for the symptoms and psychosocial conditions, respectively. A high correlation was observed with the DLQI score: symptoms (rho = 0.69) and psychosocial conditions (rho = 0.75). The instrument's two-dimensional structure was confirmed through confirmatory factor analysis. Temporal stability (ICC > 0.9) and score responsiveness (p ≤ 0.02) were verified. The instrument was shown to be feasible in clinical practice due to the content validation performed by professionals and patients, as well as the low time spent completing it (< 5 min). Study limitations: Single-center study, with patients exclusively from the public healthcare system. Conclusions: Skindex-17 was shown to be a valid and consistent instrument for assessing quality of life among patients with dermatological diseases, in Brazil. Its two-dimensional structure was confirmed.

ABSTRACT Objective: to create a scale for assessing the adherence of healthcare providers to good practices for COVID-19 in the hospital setting and determine its content and face validity. Methods: A methodological study was developed in three sequential phases: creation of items and domains based on a literature review and administration of the questionnaire to 16 nursing professionals; assessment of content and face validity by experts; and semantic analysis. Results: The 51-item scale was submitted to the evaluation of seven experts. Items with a content validity index ≥ 0.83 were maintained. During the semantic analysis performed by the administration of the scale to 37 healthcare providers, no suggestions for changes were made and the comprehension rate was 87%. Conclusions: the 47-item instrument with three dimensions (personal, organizational, and psychosocial) achieved satisfactory content and face validity, meeting the parameters established in the literature.

ABSTRACT A 6-year field monitoring study was designed to compare the presence of fall armyworm Spodoptera frugiperda (J. E. Smith), leaf injury, its parasitoids, 100 seed weight, and seed yield of Bt maize hybrids approved for commercialization in the Brazilian market. Field trials were planted in two municipalities, divided into two periods, from 2011 to 2014 (period I), and due to the approval of different Bt hybrids, from 2015 to 2016 (period II). Treatments were Bt, non-Bt maize and all non-Bt maize sprayed with insecticide methomyl. Six Bt-maize hybrids were planted, expressing the following proteins: Cry1Ab, Cry1F, Cry1A.105 (Cry1Ab +Cry1Ac +Cry1F), Cry2Ab2a and Vip3. In 2015 and 2016 Bt Powercore was planted due to its commercial approval. The number of S. frugiperda larvae for most Bt hybrids was lower than on non-Bt hybrids, except for Fórmula TL and Herculex in period II, in both municipalities. In period I, Bt hybrids VT, VT 2 and Viptera showed almost no injury on their leaves, despite the high number of fall armyworm larvae found in plants. Different parasitoids emerged from larvae from Bt and non Bt hybrids: Archytas sp., Campoletis sp., Chelonus sp., Eiphosoma sp. and Ophion luteus. The average 100 seed weight was higher in municipality from Sete Lagoas for all Bt hybrids, non-Bt hybrids and non-Bt hybrids sprayed with methomyl, when compared to Nova Porteirinha during period I. Fórmula TL, non-Bt Fórmula TL sprayed with methomyl, and non-Bt Fórmula TL showed the lowest seed yield in both municipalities and periods.

Introdução: Hipofosfatasia é um distúrbio metabólico que afeta a mineralização óssea e dentária, causada por mutações no gene ALPL, levando à deficiência enzimática da fosfatase alcalina tecido não-específica. A forma adulta caracteriza-se por fraturas atípicas do fêmur, osteomalácia, osteoporose, grave osteoartropatia, condrocalcinose e artralgia. Objetivo: Demonstrar desafios diagnósticos relacionados à hipofosfatasia através do relato de dois casos. Paciente 1: feminino, 59 anos, encaminhada para avaliação clínica devido às fraturas patológicas de difícil consolidação e osteoporose generalizada de causa genética. Relata perda dentária precoce da arcada superior, fraturas na coluna, em ombro esquerdo e no fêmur. Atualmente, queixa-se de dor crônica intensa, com uso de múltiplos medicamentos. Achados clínicos, laboratoriais e radiológicos foram compatíveis com o diagnóstico de hipofosfatasia. Paciente 2: masculino, 31 anos, filho da paciente 1, encaminhado para avaliação clínica por fratura patológica precoce em fêmur esquerdo e osteoporose não esclarecida. Atualmente relata dor e claudicação importante em membro inferior esquerdo, associado à lombalgia crônica. Confirmação do diagnóstico de hipofosfatasia por exames laboratoriais e radiológicos e sequenciamento do gene ALPL, aliados ao diagnóstico da sua genitora. Discussão: Hipofosfatasia é uma doença rara de herança autossômica dominante e recessiva. Pacientes acometidos apresentam fraturas constantes, densidade mineral óssea baixa, cicatrização óssea deficitária. É comum a hipofosfatasia ser diagnosticada erroneamente como osteopenia e/ou osteoporose primária, acarretando prejuízos ao paciente. Ressalta-se a importância da história clínica completa e dos antecedentes familiares a fim de se obter um diagnóstico precoce, garantindo, por sua vez, o adequado acompanhamento e manejo terapêutico.

Este artigo tem como objetivo compreender as percepções de futuros professores sobre o Estágio Curricular Supervisionado em Matemática (ECSM) vivenciado por eles em situação de Ensino Remoto Emergencial (ERE). O estudo, de natureza qualitativa, foi realizado no contexto da disciplina de ECSM no período de março a junho de 2021 e integrou duas professoras orientadoras, uma professora supervisora, 20 futuros professores, sendo 16 homens e quatro mulheres em trabalho semanal de oito horas, alternando encontros síncronos e assíncronos. Os dados foram construídos por meio de dois instrumentos: 1) questionário on-line a partir do Google forms, composto de 15 perguntas entre fechadas e abertas e, 2) relatórios finais - escrita descritiva e reflexiva produzida pelos futuros professores ao longo do percurso formativo. Posteriormente, eles foram tratados em aproximação aos pressupostos da análise de conteúdo Bardin (2016) e Franco (2018), o que permitiu reunir suas percepções quanto às condições físicas e tecnológicas da oferta da disciplina bem como às singularidades didático-pedagógicas de seu desenvolvimento. Os resultados mostram que os futuros professores vivenciaram condições tecnológicas favoráveis à realização do ECSM; apresentaram percepções divergentes quanto ao ERE e suas demandas por novos recursos tecnológicos, variados estilos de comunicação e interação entre professores e estudantes; percepções convergentes sobre a pertinência do percurso formativo vivenciado por eles e a necessidade de se promover, sempre, equidade tanto no ensino superior quanto na educação básica seja na pandemia, seja pós-pandemia.

Marco contextual: A resolubilidade da assistência à saúde é um conceito associado à resolução final dos problemas trazidos pelos usuários ao serviço de saúde. Objetivos: Conhecer os motivos que dificultam a resolubilidade do cuidado oftalmológico na atenção secundária de atenção à saúde, sob a perspectiva do usuário e identificar sugestões de melhoria para a mesma. Métodos: Trata-se de uma pesquisa quali-quantitativa, realizada com uma amostra não probabilística de 208 pacientes, que receberam indicação de cuidado oftalmológico em unidade de atenção secundária de saúde, de município do interior de São Paulo. As entrevistas foram gravadas, após consentimento dos participantes, transcritas e analisadas utilizando-se a estratégia metodológica do Discurso do Sujeito Coletivo. Resultados: Os motivos que atrasam a resolubilidade do cuidado são inúmeros e estão atrelados à burocracia, falta de recursos humanos e materiais, bem como inexistência da referência e contrarreferência na organização da rede de atenção à saúde. Conclusão: As dificuldades sentidas pelos usuários refletem a falta de organização desse serviço, que além de não priorizar o atendimento aos pacientes diabéticos. também não se compromete com o devido encaminhamento e acompanhamento.

Este artigo analisa as relações de coexistência entre as práticas informais de cuidados realizadas nas periferias e as administrações de Estado. A etnografia foi realizada num complexo de favelas situado na Zona Norte do Rio de Janeiro. A análise procura ressaltar as dinâmicas de interdependência entre as casas de moradoras de favela que “tomam conta” de crianças e as creches públicas. A partir das reflexões sobre os cuidados transacionados nesses espaços, busca-se refletir sobre as ideias de dependência, Estado provedor, sexualidade e reprodução feminina. A complementaridade entre esses lugares aponta para a existência de relações de cuidados nas quais dinâmicas de vulnerabilidade, escassez e demanda por recursos sociais são elementos de disputa que remetem a processos de reprodução estratificada de desigualdades históricas de gênero, classe, sexualidade, território e raça.

Abstract Objectives The primary objective is to test if heparin added to a standard regional anticoagulation protocol based on citrate is able to reduce dialysis circuit losses by clotting without increasing the risk of thrombocytopenia or bleeding, in patients with COVID-19 with acute kidney injury requiring dialysis. Trial design Randomized, parallel-group, open-label trial, with two arms (ratio 1:1) comparing different continuous renal replacement therapy anticoagulation strategies. Participants Eligibility conditions: All ICU patients of University of Sao Paulo General Hospital (Hospital das Clínicas), Brazil will be screened for eligibility conditions. Adults (> 18 years old) with confirmed COVID-19 and acute kidney injury requiring dialysis with agreement between ICU and nephrology teams for the introduction of renal continuous replacement therapy in daily ICU rounds. Continuous renal replacement therapy will be prescribed by consulting nephrologists based on standard clinical guidelines, including acute kidney injury with hemodynamic instability plus hyperkalemia, severe acidosis, volume overload, respiratory distress, multiorgan failure or some combination of these factors. Data Collection: Patients demographics and associated clinical data and comorbidities will be recorded at ICU entry. Demographic information will include the patient’s age, sex, and admission dates. Clinical data comprise comorbidities, APACHE 2, SAPS 3, need for mechanical ventilation, and use of vasopressor drugs. Physiological data collected by the day of CRRT start will be vital signs, the arterial oxygen tension/fraction of inspired oxygen (PaO2/FiO2) index, and serum creatinine, blood urea nitrogen, bilirubin, hemoglobin, hematocrit, platelets, white blood cell count levels and Peak D-dimer levels. Patients will be analyzed for the first 72h of CRRT, and they will be evaluated regarding clinical variables, filter patency and any adverse events that could be related to the anticoagulation choice, as bleeding (mild or major) or low platelets counts ( 30 mg/dL, international normalized ratio > 2.5, Total bilirubin> 15 mg/dL); Pregnancy; Patients unlikely to survive for more than 24 hours. The trial is being undertaken at the University of Sao Paulo General Hospital (Hospital das Clinicas), Brazil. Intervention and comparator Group A (control) - Patients on continuous renal replacement therapy (blood flow 150 ml/min, dose of 30 mL/Kg/h) receiving anticoagulation with sodium citrate at 4 mmol/L Group B (experiment): Patients on continuous hemodialysis (blood flow 150 mL/min, dose of 30 mL/Kg/h) receiving anticoagulation with sodium citrate at 4 mmol/L associated with unfractionated heparin at 10 U/Kg/h. Main outcomes The percentage of clotted dialyzers within 72 hours in each of the studied groups (Primary outcome) Secondary outcomes: Number of dialyzers used in the first 72 hours of dialysis protocol, Mortality in the first 72 h of dialysis protocol, Bleeding events (Major or minor) in the first 72 h of dialysis protocol, Thrombocytopenia (less than 50.000 platelets) proportion in the first 72 h of dialysis protocol, Dialysis efficiency (Urea sieving) - variation in urea sieving between the first, second and third days of dialysis protocol, Continuous renal replacement therapy pressures (Arterial, Venous, dialysate and pre-filter pressure) in the first 72 h of dialysis protocol, in-hospital mortality. Randomization RedCap→ randomization – 2 blocks randomization by D-dimer level (5000ng/dL cut-off) and catheter site (Right Internal Jugular versus other sites) with 1:1 allocation ratio. Blinding (masking) No blinding – Open label format Numbers to be randomized (sample size) Total number of patients 90 (45 per group) Trial Status Trial version 2.0 – ongoing recruitment. First recruitment: June 29, 2020 Estimated date for last recruitment: December 31, 2020 Trial registration Responsible Party: University of Sao Paulo General Hospital (Hospital das Clinicas) ClinicalTrials.gov Identifier: NCT04487990 , registered July 27, 2020, ReBec www.ensaiosclinicos.gov.br/rg/RBR-45kf9p/ Other Study ID Numbers: U1111-1252-0194 Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1) In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.

El Azospirillum es un género de bacterias promotoras del crecimiento vegetal, encontrado en suelos de diferentes regiones del globo terrestre. Estas bacterias cuando se asocian a raíces de plantas, ayudan en la producción y productividad del cultivo, actuando en el aumento de parte aérea y sistema radicular. Estos beneficios se derivan de la excreción de los fitonutrientes de crecimiento, especialmente las auxinas. En las gramíneas forrajeras, la inoculación de estas cepas puede proporcionar mayores ganancias de masa de forraje con menores dosis de N-fertilizante, garantizando la sostenibilidad del sistema de producción del pasto. El uso de Azospirillum spp., en gramíneas debe llenar un vacío entre la productividad y la sostenibilidad. La promoción del crecimiento proporcionado por Azospirillum se ha descrito en varias gramíneas como la caña de azúcar, el maíz y plantas forrajeras, pero se deben realizar más estudios en diferentes condiciones para diseminar y consolidar su adopción entre los productores. La adopción de la inoculación de esta bacteria puede aumentar la competitividad de los productos agrícolas y ser un diferencial frente a la producción adoptada en la agricultura convencional. En la ganadería la inoculación en pastizales puede aumentar la producción de masa de forraje, y mitigar los riesgos de degradación y mejorar los índices productivos de ese sector.

Objetivou-se avaliar as características morfogênicas e estruturais do capim-piatã submetido à lotação intermitente e adubado com fontes de fósforo de diferentes solubilidades e adubação nitrogenada. Os tratamentos foram: controle (sem aplicação de adubo fosfatado); fonte de fósforo de lenta solubilidade (FNR); fonte de fósforo de rápida solubilidade (FSS) e fonte de fósforo de solubilidade mista (FSM), associados ou não à adubação nitrogenada. Foram realizadas medições de perfilhos pré-demarcados para avaliação das características estruturais e morfogênicas das plantas. Os dados foram analisados segundo um delineamento em blocos casualizados, em arranjo fatorial 4 x 2, dentro de cada estação do ano. As médias por quadrados mínimos dos tratamentos de adubação fosfatada foram comparadas com o tratamento controle pelo teste de Dunnet, e entre si pelo teste "t" e as médias de uso ou não de adubação nitrogenada foram comparadas entre si pelo teste "t" a 5% de significância. As fontes que contém fósforo prontamente disponível, como nos tratamentos FSS e FSM, promoveram maior alongamento de folhas e colmo, bem como maior número e aparecimento de folhas, o que evidencia a importância da disponibilidade de fósforo e nitrogênio no crescimento e desenvolvimento das plantas, confirmado pelo aumento na taxa de alongamento de folhas, do aparecimento foliar e alongamento de colmo. Assim, as adubações nitrogenada e fosfatada são alternativas para a persistência e competitividade da produção animal a pasto. Em relação à fonte, o uso de fontes de fósforo com solubilidade mista fornece esse nutriente a curto, médio e longo prazo. Palavras-chave: adubação de pastagens; caracterização morfogênica; produção em pasto; Urochloa brizantha cv.BRS Piatã.

Objetivo: Conhecer como a psoríase interfere na qualidade de vida dos pacientes na percepção de dermatologistas e identificar estratégias para melhoria e reorganização da assistência. Métodos: Pesquisa exploratória e descritiva, realizada em hospital público do interior de São Paulo, no período de dezembro de 2017 a março de 2018, com seis dermatologistas. As entrevistas foram transcritas e analisadas utilizando-se a estratégia metodológica do Discurso do Sujeito Coletivo. Resultados: Psoríase é uma doença que inflige prejuízo à qualidade de vida por estar associada a transtornos psicossociais, estigma, vergonha e perda da autoestima. Reduzir lesões e sintomas, melhorar a aparência, disponibilizar medicamento eficaz e oferecer atendimento humanizado são aspectos fundamentais para melhoria da qualidade de vida destes pacientes. Conclusão: Para os profissionais dermatologistas, a psoríase é uma doença crônica, que interfere na qualidade de vida dos pacientes, em virtude do preconceito sentido, dos transtornos psicossociais e sentimentos negativos que afloram, bem como das dificuldades sociais enfrentadas.

ObjectiveTo compare the psychometric performance of the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16 to assess quality of life (QoL) in Brazilian patients with dermatological diseases.MethodsThis was a cross-sectional study carried out in a dermatology outpatient clinic of the São Paulo State University, with 188 patients with dermatological diseases. QoL was evaluated using the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16. Cronbach's alpha and Intraclass Correlation for Perfect Concordance (ICC) were used to analyse the reliability and temporal stability, respectively.ResultsA positive correlation was found between the total Skindex-16 score and DLQI-BRA (0.75). Both instruments showed a significant (p< 0.01) reduction in their scores at the second assessment, demonstrating that they were sensitive in detecting changes in responsiveness in cases where there was a clinical change. Cronbach alpha coefficients for the instruments showed satisfactory performance (>0,7), but Skindex-16 displayed the highest Cronbach alpha (0.94; CI = 0.93-0.95).ConclusionBoth instruments tested showed a good psychometric performance assessing QoL in patients with skin dermatoses. The instruments displayed reliability and temporal stability as well as responsiveness.

The improvement of acoustic performance construction systems is crucial. The flaws found during the design of a building are often related to the lack of data that characterize the materials used. Floor slab systems are one of the materials that influence acoustic performance, out of which composite slabs made of ribs and hollow bricks show up as common alternatives. The acoustic performance of this specific material is not entirely known, considering the multitude of coatings that can be added. Therefore, this study compared measurements on impact sound pressure level for one-way rib and hollow brick slabs using multiple coatings and gypsum ceiling, besides the 120 mm thick solid concrete refence slab. The coatings included the use of a concrete cover (50 mm); concrete cover (50 mm) + resilient layer (10 mm) + screed (40 mm); concrete cover (50 mm) + resilient layer (10 mm) + screed (40 mm) + gypsum board ceiling with thickness of 12.5 mm and plenum of 150 mm; concrete cover (50 mm) + screed (40 mm) + the above-mentioned gypsum ceiling; and concrete cover (50 mm) + screed (40 mm). The tests were performed in a vertical acoustic resonant chamber built according to ISO 10140-5:2010. The results showed that the use of gypsum ceiling along with resilient layer under the mortar screed reduced the weighted impact sound pressure level by 41 dB, compared to other samples.

This article analyzes childcare houses in Rio de Janeiro’s favelas. I discuss the modalities of child custody, negotiations over pricing, and the main moral dilemmas that women experience. The houses are located at the margins of the state, understood not as the bankruptcy of the public sector but as territories of production of vulnerability. Thus, the houses are constituted as spaces that produce life and resistance in a context of gender, racial, and class inequality.

Framework: Although gestation marks some of the most important moments in a woman’s life, it becomes complex when associated with the problems, limitations, and risks inherent in heart disease. Objective: to comprehend the meanings women with heart disease attribute to their high-risk pregnancy and to identify their perception of the risks to the mother-child binomial. Methodology: A quantiqualitative study involving 39 pregnant women with heart disease from a public university of an inland city of São Paulo, Brazil, was conducted. Data were collected through interviews with patients and analyzed using the Discourse of the Collective Subject. Results: This study showed high-risk gestation is a process linked to personal satisfaction and fulfillment of a dream, often associated with a lack of planning, uncertainties and fears. Some participants anchored in religion/spirituality to overcome difficulties, while others used self-reliance as a support. The risks are poorly understood and often underestimated. Conclusion: High-risk gestation is a process associated with personal satisfaction, fulfillment of a dream and even a common experience, often permeated by negative feelings about the inevitable risks to the mother-child binomial.

ABSTRACT Objective: To identify factors associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in adult patients admitted to the Intensive Care Unit (ICU), and to compare them with a control group. Methods: Retrospective case-control study carried out in an adult ICU, from January 2015 to June 2017, with 61 patients who developed methicillin-resistant Staphylococcus aureus infection and the same number of control patients. Results: Most participants were male 65 (60.6%), with a neurological diagnosis 43 (35.2%) and hypertensive 61 (50.0%). In the comparison of the groups, there was a statistically significant difference in relation to mechanical ventilation (p=0.0107), tracheostomy (p=0.0083), death (p=0.0401), urinary catheter (p=0.0420), length of stay (p

We evaluated the growth and body traits of pacu and tambacu hybrid reared in cages and fed through different feeding programmes. Six treatments in a factorial scheme, with two genetic groups (pacu and tambacu) and three feeding programmes, were tested in 12 cages. In each cage, 50 juveniles (pacu, 120 ± 31 g; tambacu, 119 ± 28 g) were stocked and fed according to three feeding programmes using three commercial diets containing 24%, 28% or 32% crude protein in different combinations during 167 days. Measurements were performed on ten animals sampled from each experimental unit at days 30, 60 and 167 of the experiment, and the weights were recorded. During the final sampling, in addition to weights, the measurements of standard length, head length, height and body width were recorded. Five of the ten animals sampled at 167 days were euthanised and processed to obtain the carcass, rib, fillet, gut and fat yields. The fillets from two of the five processed fish were used to determine the chemical composition. Data were submitted to analysis of variance and means were compared by the SNK test. The pacu group presented higher weight averages than the tambacu throughout the experiment, especially when the animals were fed by the programme with the lowest dietary protein levels. Body shape and yields were also more noteworthy for the pacu group; however, the pure animals also presented higher lipid values in the fillet, which may be a negative aspect of the final product consumed. In general, tambacu hybrid production in cages does not seem to be an interesting alternative to the farming of the pure parental species.

Abstract: The objective of this work was to evaluate the supplementation of diet of pacu and tambacu with acid fish silage during winter. The experimental design was a 2 × 2 factorial arrangement (two genetic groups and two diets), with three replicates. The genetic group factor was composed of pacu (Piaractus mesopotamicus) and tambacu (♀ Colossoma macropomum × ♂ Piaractus mesopotamicus). The two diets were based on plant ingredients; one of them was supplemented with acid fish silage (silage diet), and the other was a base diet without supplementation. Twelve net tanks, six from which with pacu, and six with tambacu, were used as experimental units, with ten fish in each tank. There was an interaction of the factors for final length, final weight, and daily weight gain. Pacu fed the silage diet showed a higher growth than pacu fed with the base diet; however, this effect was not observed for tambacu. A higher feed efficiency was observed for pacu than for tambacu, without a diet effect. The diet supplementation with acid fish silage improves the productive performance of pacu reared at cold suboptimal temperature, but it does not have this effect on tambacu.

A partir do final do século XVII a região central do Brasil foi palco de um intenso processo de exploração mineral -ouro e diamantes- que passou à história, identificado através da denominação de “Ciclo do Ouro”. Utilizando técnicas desenvolvidas em função das condições ambientais, a atividade mineraria provocou impactos no ambiente/ paisagem que ainda hoje podem ser identificados como vestígios arqueológicos. A destruição da cobertura vegetal, as alterações radicais no relevo, o assoreamento e o ressecamento dos cursos d’água, são alguns dos impactos provocados por aquele processo extrativo. As antigas áreas exploradas apresentam hoje evidências de um processo natural de recuperação colocando os vestígios arqueológicos na condição de elementos a serem preservados, tanto na perspectiva patrimonial quanto ambiental. Este trabalho pretende abordar a forma como tais vestígios se apresentam bem como sua relevância para o estudo da história da mineração, da degradação ambiental e da questão patrimonial.

A historiografia da arte relativa à capitania das Minas Gerais, desde a década de 1930, aponta a relevância especial dos missais portugueses, editados pela Impressão Régia, como fontes de modelos gravados para os pintores. O presente artigo objetiva reacender esse debate, deslocando-o do tradicional eixo interpretativo iconográfico e formal, ou seja, não enfatiza a análise das apropriações das gravuras portuguesas pelos pintores mineiros. Objetiva, diferentemente, compreender o processo de produção desses modelos em Lisboa tendo em vista as políticas econômicas adotadas em Portugal, na segunda metade do século XVIII, com vistas a favorecer e proteger a incipiente industrialização lusitana, substituindo importações. O enfoque recai sobre o estudo da produção dos livros e suas estampas, as concessões de privilégios de impressão aos lusitanos e a proibição de importação de missais estrangeiros, medidas tomadas desde a década de 1760. Conclui-se que essas investidas protecionistas tiveram como consequência o predomínio desses livros no mercado de missais na capitania das Minas, o que interferiu, por sua vez, no universo de insinuações artísticas europeias ali disponíveis, uma vez que suas estampas apresentavam pendores classicizantes, de origem italiana.

Abstract: BACKGROUND: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL. OBJECTIVE: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. METHODS: Cross-sectional study performed in 2 institutions (public and private) from Brazil. Two focus groups were carried out: 5 board-certified dermatologists and 10 melasma patients, indicating the dimensions and significant units of melasma QoL. The preliminary questionnaire with 49 itens was applied to 154 facial melasma patients. Item reduction was performed by Rasch analysis. Parallel evaluations of clinical (MASI), demographic, and QoL aspects (MELASQoL, DLQI) were performed. The dimensional structure was assessed by confirmatory factor analysis. Temporal stability was tested in a subgroup of 42 individuals within 7-14 days. RESULTS: The mean (SD) age of the 154 interviewed subjects was 39±8 years, and 87% were females. The median (p25-p75) DLQI and MELASQoL were: 2 (1-6) and 30 (17-44). HRQ-Melasma consisted of 19 items distributed in 4 dimensions: Physical/Appearance, Social/Professional, Psychological, and Treatment. Cronbach’s alpha for HRQ-Melasma was 0.96, and >0.74 for each dimension. There was high correlation between HRQ-Melasma and DLQI and MELASQoL (rho=0.80 and 0.83), but modest with MASI (rho=0.35). Dimensional structure of HRQ-Melasma was stated by confirmatory factor analysis coefficients. Test-retest analysis disclosed an intraclass correlation coefficient of 0.91 (p

Objetivou-se avaliar as características estruturais e morfogênicas do capim-convert HD364® em resposta à adubação fosfatada de diferentes solubilidades em água e ácido, durante as estações do ano. Utilizou-se o híbrido do gênero Urochloa spp, capim-convert HD364®, submetido a quatro tratamentos em delineamento em blocos ao acaso, sendo: Controle (sem adubação fosfatada), SS (Solubilidade rápida em água), FNR (Solubilidade lenta em ácido) e FH (Solubilidade mista). Semanalmente, durante as estações de primavera, verão e outono, foram realizadas as mensurações das características estruturais e morfogênicas descritas: TApF; TAlF; TSeF; TAlC; DVF; Filocrono e NFV. Observou-se efeito significativo (p < 0,05) na variável NFV com a utilização do FNR na estação de primavera, e na estação de outono observou-se efeito significativo nas variáveis TAlC e TAlF com a fonte de fósforo FH. Conclui-se que a fonte de fósforo de solubilidade mista pode ter influenciado na estrutura morfogênica do capim-convert HD364®, diminuindo o alongamento de colmo e aumento da lâmina foliar, podendo determinar facilidade no manejo de descanso no início do período seco.

Neste trabalho, discutem-se usos de construções condicionais e completivas insubordinadas no português do Brasil, a partir das reflexões teóricas desenvolvidas particularmente por Evans (2007), Mithun (2008), Gras (2011), D’Hertefelt (2015), Sansiñena (2015) e Hirata-Vale (2015, 2017). Insubordinação é conhecido como o processo pelo qual construções que apresentam uma marca qualquer de subordinação passam a ser usadas independentemente, sem que estejam conectadas a uma oração principal. Embora possam parecer construções idiossincráticas, usadas apenas esporadicamente pelos falantes, as pesquisas acerca dessas construções constatam que elas são bastante frequentes e realizam estratégias discursivo-pragmáticas específicas. Desse modo, o objetivo deste trabalho é descrever essas construções no português do Brasil, apresentando suas características discursivas e funcionais.

ABSTRACT BACKGROUND AND OBJECTIVES: Different types of exercises are being used for the treatment of fibromyalgia, such as aerobic, resistance, flexibility exercises and body awareness therapy, but there is strong evidence that the gold standard for the non-pharmacological treatment of this disease is the aerobic exercise. The objective of this study was to collect reports of patients with fibromyalgia who practiced three months of dance (Zumba) and had to stop dancing for three months due to the recess of the academic activity at the end of 2016 and beginning of 2017. CASE REPORTS: This is a qualitative study about the experience of 16 women with fibromyalgia, who participated in Zumba class for three months in 2016. The reports were collected when they resumed their dance activities in March 2017. Therefore, the patients remained with no intervention for three months, during the academic recess. The patients wrote their reports on a sheet of paper, answering three questions. According to the reports, we noticed that Zumba brought several benefits for these patients, such as pain relief, improved sleep quality, self-esteem and physical performance. CONCLUSION: Based on patients’ reports we can conclude that Zumba, as a three-month intervention, produced positive effects in improving pain, functional capacity, and quality of life of women with fibromyalgia.